journal
Journals International Journal of Chron...

International Journal of Chronic Obstructive Pulmonary Disease

https://read.qxmd.com/read/38444551/exacerbation-burden-in-copd-and-occurrence-of-mortality-in-a-cohort-of-italian-patients-results-of-the-gulp-study
#21
MULTICENTER STUDY
Pierachille Santus, Fabiano Di Marco, Fulvio Braido, Marco Contoli, Angelo Guido Corsico, Claudio Micheletto, Girolamo Pelaia, Dejan Radovanovic, Paola Rogliani, Laura Saderi, Nicola Scichilone, Silvia Tanzi, Manlio Vella, Silvia Boarino, Giovanni Sotgiu, Paolo Solidoro
OBJECTIVE: To describe the burden of moderate to severe exacerbations and all-cause mortality; the secondary objectives were to analyze treatment patterns and changes over follow-up. DESIGN: Observational, multicenter, retrospective, cohort study with a three year follow-up period. SETTING: Ten Italian academic secondary- and tertiary-care centers. PARTICIPANTS: Patients with a confirmed diagnosis of COPD referring to the outpatient clinics of the participating centers were retrospectively recruited...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38444550/association-between-serum-anion-gap-and-mortality-in-critically-ill-patients-with-copd-in-icu-data-from-the-mimic-iv-database
#22
JOURNAL ARTICLE
Xiaojing Chen, Qilin Yang, Li Gao, Weinan Chen, Xiaoyu Gao, Yameng Li, Liying Ao, Dejun Sun
BACKGROUND: Serum anion gap (AG) has been proven to be associated with prognosis in critically ill patients. However, few studies have investigated the association between AG and all-cause mortality in critically ill patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: We hypothesized that the initial AG level would predict the mortality risk in critically ill patients with COPD. METHODS: This retrospective cohort study was based on the Medical Information Mart for Intensive Care (MIMIC) IV database...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38440747/respiratory-infection-triggering-severe-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#23
JOURNAL ARTICLE
Georges Abi Abdallah, Sylvain Diop, Matthieu Jamme, Stéphane Legriel, Alexis Ferré
BACKGROUND: Data are scarce on respiratory infections during severe acute exacerbation of chronic obstructive pulmonary disease (COPD). This study aimed to investigate respiratory infection patterns in the intensive care unit (ICU) and identify variables associated with infection type and patient outcome. METHODS: A retrospective, single-centre cohort study. All patients admitted (2015-2021) to our ICU for severe acute exacerbation of COPD were included. Logistic multivariable regression analysis was performed to predict factors associated with infection and assess the association between infection and outcome...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38435125/tritrial-the-impact-of-fixed-triple-therapy-with-beclometasone-formoterol-glycopyrronium-on-health-status-and-adherence-in-chronic-obstructive-pulmonary-disease-in-an-italian-context-of-real-life
#24
MULTICENTER STUDY
Luca Richeldi, Pietro Schino, Elena Bargagli, Alberto Ricci, Alberto Rocca, Francesca Marchesani, Alfio Pennisi, Gianna Camiciottoli, Maria D'Amato, Francesco Macagno, Ulrica Scaffidi Argentina, Eleonora Ingrassia, Alessio Piraino
PURPOSE: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient's experience and perspective through the use of patients reported outcomes. PATIENTS AND METHODS: TRITRIAL was a multicenter, prospective, observational study conducted on patients with moderate-severe COPD treated with BDP/FF/G fixed therapy for 12 months...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38435124/association-between-serum-klotho-and-chronic-obstructive-pulmonary-disease-in-us-middle-aged-and-older-individuals-a-cross-sectional-study-from-nhanes-2013-2016
#25
JOURNAL ARTICLE
Yushan Shi, Zhangmeng Xu, Shuangshuang Pu, Kanghong Xu, Yanan Wang, Chunlai Zhang
PURPOSE: This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States. PATIENTS AND METHODS: This study was a cross-sectional analysis involving 4361 adults aged 40-79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic regression and restricted cubic spline (RCS) regression to explore the potential correlation between serum Klotho concentrations and the prevalence of COPD...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38435123/analysis-of-key-genes-and-mirna-mrna-networks-associated-with-glucocorticoids-treatment-in-chronic-obstructive-pulmonary-disease
#26
JOURNAL ARTICLE
Jian-Jun Wu, Ping-An Zhang, Ming-Zhe Chen, Yi Zhang, Wei-Sha Du, Xiao-Ning Li, Guo-Chao Ji, Liang-Duo Jiang, Yang Jiao, Xin Li
BACKGROUND: Some patients with chronic obstructive pulmonary disease (COPD) benefit from glucocorticoid (GC) treatment, but its mechanism is unclear. OBJECTIVE: With the help of the Gene Expression Omnibus (GEO) database, the key genes and miRNA-mRNA related to the treatment of COPD by GCs were discussed, and the potential mechanism was explained. METHODS: The miRNA microarray dataset (GSE76774) and mRNA microarray dataset (GSE36221) were downloaded, and differential expression analysis were performed...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38414720/acute-exacerbation-and-longitudinal-lung-function-change-of-preserved-ratio-impaired-spirometry
#27
JOURNAL ARTICLE
Si Mong Yoon, Kwang Nam Jin, Hyo Jin Lee, Hyun Woo Lee, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Jung-Kyu Lee
BACKGROUND: Preserved ratio impaired spirometry (PRISm) is a heterogeneous disease entity. Limited data are available regarding its prevalence, clinical course, or prognosis. We aimed to evaluate the longitudinal clinical course of patients with PRISm compared with chronic obstructive pulmonary disease (COPD). METHODS: A retrospective study enrolled PRISm and COPD patients who underwent chest computed tomography and longitudinal pulmonary function tests between January 2013 and December 2020...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38414719/lack-of-evidence-regarding-markers-identifying-acute-heart-failure-in-patients-with-copd-an-ai-supported-systematic-review
#28
REVIEW
Sanne H B van Dijk, Marjolein G J Brusse-Keizer, Charlotte C Bucsán, Eline H Ploumen, Wendy J C van Beurden, Job van der Palen, Carine J M Doggen, Anke Lenferink
BACKGROUND: Due to shared symptoms, acute heart failure (AHF) is difficult to differentiate from an acute exacerbation of COPD (AECOPD). This systematic review aimed to identify markers that can diagnose AHF underlying acute dyspnea in patients with COPD presenting at the hospital. METHODS: All types of observational studies and clinical trials that investigated any marker's ability to diagnose AHF in acutely dyspneic COPD patients were considered eligible for inclusion...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38414718/platelet-to-lymphocyte-ratio-plr-neutrophil-to-lymphocyte-ratio-nlr-monocyte-to-lymphocyte-ratio-mlr-and-eosinophil-to-lymphocyte-ratio-elr-as-biomarkers-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-aecopd
#29
JOURNAL ARTICLE
Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang
PURPOSE: The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). PATIENTS AND METHODS: Six hundred and nineteen patients with AECOPD and 300 healthy volunteers were retrospectively included into the study...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38410140/gstp1-rs4147581-c-g-and-nlrp3-rs3806265-t-c-as-risk-factors-for-chronic-obstructive-pulmonary-disease-a-case-control-study
#30
JOURNAL ARTICLE
Honge Li, Raorao Wang, Xueyan Wei, Chunyan Zhang, Wenhui Pei, Xuhui Zhang, Zhen Yang, Zhi Li, Yuhuan Zhang, Yanli Shi, Yunchao Wang, Xinhua Wang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in the pulmonary system. The activation of the NOD-like receptor thermal protein domain (NLRP3) inflammatory vesicle can trigger an inflammatory response...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38404653/relationship-between-systemic-immune-inflammation-index-and-risk-of-respiratory-failure-and-death-in-copd-a-retrospective-cohort-study-based-on-the-mimic-iv-database
#31
JOURNAL ARTICLE
Ye Zhang, Xiaoli Tan, Shiyu Hu, Zhifang Cui, Wenyu Chen
PURPOSE: Chronic obstructive pulmonary disease (COPD) concurrent with respiratory failure (RF) is devastating, and may result in death and disability. Systemic immune-inflammation index (SII) is a new prognostic biomarker linked to unfavorable outcomes of acute coronary syndrome, ischemic stroke, and heart failure. Nonetheless, its role in COPD is rarely investigated. Consequently, this study intends to assess the accuracy of SII in predicting the prognosis of COPD. PATIENTS AND METHODS: The clinical information was retrospectively acquired from the Medical Information Mart for Intensive Care-IV database...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38374818/case-finding-and-treatment-effects-in-copd-secondary-analysis-of-an-interdisciplinary-intervention-trial
#32
RANDOMIZED CONTROLLED TRIAL
Kate Petrie, Michael J Abramson, Johnson George
BACKGROUND: US Preventive Services Taskforce recommends against screening for COPD in asymptomatic adults due to limited evidence on the efficacy of treatments for this population. However, global and Australian guidelines recommend a case-finding approach where those with symptoms and/or risk factors, including smoking, are screened. This study aims to explore patient characteristics by time of COPD diagnosis and the effectiveness of early treatment in those with or without symptoms...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38374817/inpatient-admissions-and-re-admissions-in-medicare-beneficiaries-initiating-umeclidinium-vilanterol-or-tiotropium-therapy
#33
JOURNAL ARTICLE
Michael Bogart, Gary Yat-Hung Leung, Anissa Cyhaniuk, Kristi DiRocco
PURPOSE: Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized are more likely to die from their illness and have increased likelihood of re-admission than those who are not. Subsequent re-admissions further increase the burden on healthcare systems. This study compared inpatient admission rates and time-to-first COPD-related inpatient admission among Medicare beneficiaries with COPD indexed on umeclidinium/vilanterol (UMEC/VI) versus tiotropium (TIO). PATIENTS AND METHODS: This retrospective study used the All-Payer Claims Database to investigate hospital admission and re-admission outcomes in Medicare beneficiaries with COPD with an initial pharmacy claim for UMEC/VI or TIO from 1 January 2015 to 28 February 2020...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38371231/glucocorticoid-use-in-patients-hospitalized-with-chronic-obstructive-pulmonary-disease-exacerbations
#34
JOURNAL ARTICLE
Songsong Yu, Shuang Li, Jie Zhang, Qiuhong Fang
OBJECTIVE OF THE STUDY: Systemic glucocorticoid therapy can improve the outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The study tried to investigate the use of glucocorticoids in AECOPD patients and the factors associated with the physicians' choice. METHODOLOGY: Patients with AECOPD over two periods were divided by the year of 2017 when GOLD and ERS/ATS Guideline for COPD were updated. Data of patients regarding the study was retrieved from medical records...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38348310/identification-and-characterization-of-a-cerna-regulatory-network-involving-linc00482-and-prrc2b-in-peripheral-blood-mononuclear-cells-implications-for-copd-pathogenesis-and-diagnosis
#35
JOURNAL ARTICLE
Wenjie Huang, Ting Luo, Mengqiu Lan, Wenting Zhou, Ming Zhang, Lihong Wu, Zhenni Lu, Li Fan
PURPOSE: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, characterized by intense lung infiltrations of immune cells (macrophages and monocytes). While existing studies have highlighted the crucial role of the competitive endogenous RNA (ceRNA) regulatory network in COPD development, the complexity and characteristics of the ceRNA network in monocytes remain unexplored. METHODS: We downloaded messenger RNA (mRNA), microRNA (miRNA), and long noncoding RNA (lncRNA) microarray data from GSE146560, GSE102915, and GSE71220 in the Gene Expression Omnibus (GEO) database...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38343495/lianhua-qingke-preserves-mucociliary-clearance-in-rat-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-by-maintaining-ciliated-cells-proportion-and-protecting-structural-integrity-and-beat-function-of-cilia
#36
JOURNAL ARTICLE
Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia
PURPOSE: Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is a sudden worsening of symptoms in patients with Chronic Obstructive Pulmonary Disease (COPD), such as cough, increased sputum volume, and sputum purulence. COPD and AECOPD are characterized by damage to cilia and increased mucus secretion. Mucociliary clearance (MCC) functions as part of the primary innate system of the lung to remove harmful particles and pathogens together with airway mucus and is therefore crucial for patients with COPD...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38343494/prevalence-and-associated-factors-of-chronic-obstructive-pulmonary-disease-among-adults-in-neno-district-malawi-a-cross-sectional-analytical-study
#37
JOURNAL ARTICLE
Haules Robbins Zaniku, Emilia Connolly, Moses Banda Aron, Beatrice Lydia Matanje, Myness Kasanda Ndambo, George Complex Talama, Fabien Munyaneza, Todd Ruderman, Jamie Rylance, Luckson Wandani Dullie, Rejani Lalitha, Ndaziona Peter Kwanjo Banda, Adamson S Muula
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) continues to pose a global public health challenge. However, literature is scarce on the burden of COPD in Malawi. We assessed the prevalence and risk factors for COPD among adults in Neno, Malawi. METHODOLOGY: We conducted a population-based analytical cross-sectional study in Neno District between December 2021 and November 2022. Using a multi-stage sampling technique, we included 525 adults aged≥40 years...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38343493/prevalence-and-risk-factors-of-chronic-obstructive-pulmonary-disease-among-users-of-primary-health-care-facilities-in-morocco
#38
JOURNAL ARTICLE
Nadia Al Wachami, Maryem Arraji, Younes Iderdar, Yassmine Mourajid, Karima Boumendil, Fatima Zahra Bouchachi, Samira Jaouhar, Morad Guennouni, Fatimazahra Laamiri, Noureddine Elkhoudri, Lahcen Bandadi, Mohamed Lahbib Louerdi, Abderraouf Hilali, Mohamed Chahboune
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major public health problem. In Morocco, few studies have focused on COPD in primary health care facilities, whose main mission is prevention. The aim of our work is thus to assess the prevalence of COPD and to study the factors associated with this silent disease among users of health care facilities in Morocco. METHODS: This is a cross-sectional observational study of participants aged 40 and over. Data were collected by questionnaire...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38333775/alpha-1-antitrypsin-gene-variants-in-patients-without-severe-deficiency-diagnosed-with-pulmonary-emphysema-on-chest-ct
#39
JOURNAL ARTICLE
Eduardo Laviña, Sara Lumbreras, Lara Bravo, Joan B Soriano, José Luis Izquierdo, Jose Miguel Rodríguez
INTRODUCTION: Although pulmonary involvement due to alpha-1 antitrypsin (AAT) deficiency has been widely described, most studies focus on the genotypes causing severe deficiency (<60 mg/dL). OBJECTIVE: The aim of this study was to analyze the prevalence of the different AAT gene variants that do not cause severe deficiency in patients with pulmonary emphysema diagnosed by thoracic computed tomography (CT). Furthermore, we assessed the risk associated with a non-severe decrease in AAT values in the pathogenesis of emphysema...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38333774/circular-rna_0025843-alleviated-cigarette-smoke-extract-induced-bronchoalveolar-epithelial-cells-ferroptosis
#40
JOURNAL ARTICLE
Jia Chen, Xiaoyu Deng, Hansheng Xie, Caiyun Wang, Jiefeng Huang, Ningfang Lian
PURPOSE: Circular RNA (circRNA) plays an important role in various biological processes. However, their functions in cigarette smoke extract (CSE) induced human normal lung epithelial cells (BEAS-2B) injury remain vague. The study aimed to explore circRNA expression profiles and reveal their potential roles in CSE-treated BEAS-2B cells. METHODS: 5% CSE exposure for 24 hours were used to build the BEAS-2B cells ferroptosis model. Differentially expressed circRNAs (DECs) were identified by next-generation RNA sequencing...
2024: International Journal of Chronic Obstructive Pulmonary Disease
journal
journal
41349
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.