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International Journal of Chronic Obstructive Pulmonary Disease

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https://www.readbyqxmd.com/read/30323582/laba-lama-fixed-dose-combinations-in-patients-with-copd-a-systematic-review
#1
REVIEW
Paola Rogliani, Luigino Calzetta, Fulvio Braido, Mario Cazzola, Enrico Clini, Girolamo Pelaia, Andrea Rossi, Nicola Scichilone, Fabiano Di Marco
Objectives: The aim of this study was to assess the current evidence for long-acting β2 -agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations (FDCs) in the treatment of COPD. Materials and methods: A systematic literature search of randomized controlled trials published in English up to September 2017 of LABA/LAMA FDCs vs LABA or LAMA or LABA/inhaled corticosteroid (ICS) FDCs in COPD patients was performed using PubMed, Embase, Scopus, and Google Scholar...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30323581/effects-of-yupingfeng-granules-on-acute-exacerbations-of-copd-a-randomized-placebo-controlled-study
#2
Jinfang Ma, Jinping Zheng, Nanshan Zhong, Chunxue Bai, Haoyan Wang, Juan Du, Fenglei Li, Yanwei Chen, Zhe Shi, Xin Li, Pingyan Chen
Purpose: Recurrence of acute exacerbations has a major impact on patients with COPD. Therefore, effective prevention and treatment of exacerbation is crucial in the management of COPD, especially for patients with moderate to severe disease. This study evaluated the effectiveness of YuPingFeng granule administration in preventing exacerbation and improving symptom score, as well as its long-term (1 year) safety profile, in patients with COPD. Patients and methods: This was a randomized, double-blind, parallel, placebo-controlled study of 240 patients from eight centers in China...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30323580/enlightening-chronic-obstructive-pulmonary-disease-through-patients-and-caregivers-narratives
#3
Valeria Gatti, Paolo Banfi, Stefano Centanni, Salvatore D'Antonio, Saffi Giustini, Alessio Piraino, Marco Zibellini, Maria Giulia Marini
Purpose: The primary aim of this research was to raise awareness for COPD through real narratives of patients, caregivers, and pulmonologists. The second objective includes providing clinicians new means of caring for and treating patients with COPD. Methods: Using narrative medicine, testimonies from patients, their caregivers, and clinicians were collected through an online questionnaire enriched by a narrative plot. Narrations were analyzed throughout descriptive statistics and an elaboration of recurring words and expressions...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30323579/use-of-medicines-and-health-services-for-chronic-obstructive-pulmonary-disease-among-a-cohort-of-australians-over-50-years
#4
Renly Lim, Mhairi Kerr, Elizabeth E Roughead
Background: It is not known if the medicines and services for COPD are used in Australia according to the COPD-X guideline. This study examined the use of medicines and health services for COPD among an Australian cohort to determine if they were consistent with recommendations. Methods: The administrative claims data from the Australian Government Department of Veterans' Affairs were used and included persons aged ≥50 years who were using medicines for COPD in April 2016...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30323578/-pseudomonas-aeruginosa-infection-increases-the-readmission-rate-of-copd-patients
#5
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang, Kyung Hoon Min
Introduction: Acute exacerbation of COPD (AECOPD) leads to rapid deterioration of pulmonary function and quality of life. It is unclear whether the prognosis for AECOPD differs depending on the bacterium or virus identified. The purpose of this study is to determine whether readmission of patients with severe AECOPD varies according to the bacterium or virus identified. Methods: We performed a retrospective review of medical records of 704 severe AECOPD events at Korea University Guro Hospital from January 2011 to May 2017...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30323577/validity-of-icd9-cm-codes-to-diagnose-chronic-obstructive-pulmonary-disease-from-national-health-insurance-claim-data-in-taiwan
#6
Te-Wei Ho, Sheng-Yuan Ruan, Chun-Ta Huang, Yi-Ju Tsai, Feipei Lai, Chong-Jen Yu
Purpose: Claim data from Taiwan's National Health Insurance (NHI) database have previously been utilized in the study of COPD. However, there are limited data on the positive predictive value of claim data for COPD diagnosis. Therefore, this study aimed to characterize and validate the COPD cohort identified from the NHI research database. Methods: This cross-sectional study compared records from claim data with those from a medical center. From 2007 to 2014, a COPD cohort was constructed from claim data using ICD9-CM codes for COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319252/eosinophil-counts-in-first-copd-hospitalizations-a-comparison-of-health-service-utilization
#7
Maryse Bélanger, Simon Couillard, Josiane Courteau, Pierre Larivée, Thomas G Poder, Nathalie Carrier, Kim Girard, Felix-Antoine Vézina, Alain Vanasse
Purpose: Current evidence suggests that a higher blood eosinophil cell count at admission for acute exacerbation of COPD (AECOPD) is associated with a favorable response to systemic steroids. However, the impact of blood eosinophil counts at admission on post-hospitalization outcomes is still unclear. The main objective of this study is to investigate readmission outcomes associated with blood eosinophilia following severe COPD exacerbation in patients with infrequent COPD hospitalizations...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319251/significances-of-spirometry-and-impulse-oscillometry-for-detecting-small-airway-disorders-assessed-with-endobronchial-optical-coherence-tomography-in-copd
#8
Zhu-Quan Su, Wei-Jie Guan, Shi-Yue Li, Ming Ding, Yu Chen, Mei Jiang, Xiao-Bo Chen, Chang-Hao Zhong, Chun-Li Tang, Nan-Shan Zhong
Background: Spirometry confers limited value for identifying small-airway disorders (SADs) in early-stage COPD, which can be detected with impulse oscillometry (IOS) and endobronchial optical coherence tomography (EB-OCT). Whether IOS is useful for reflecting small-airway morphological abnormalities in COPD remains unclear. Objectives: To compare the diagnostic value of spirometry and IOS for identifying SADs in heavy-smokers and COPD based on the objective assessment with EB-OCT...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319250/women-manifest-more-severe-copd-symptoms-across-the-life-course
#9
Dawn L DeMeo, Sreeram Ramagopalan, Abhishek Kavati, Ashok Vegesna, Meilan K Han, Anthony Yadao, Teresa K Wilcox, Barry J Make
Background: Previous studies suggest that gender differences exist in COPD diagnosis and symptoms; these differences may be more pronounced in younger adults. Our objective was to explore age-associated gender differences across a range of COPD severities. Materials and methods: A total of 4,484 current and former smokers with COPD from the Genetic Epidemiology of COPD cohort were investigated using regression modeling to explore the association between gender, age, disease severity, and the contributing elements of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system (symptoms, exacerbation risk, airflow limitation)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319249/comparison-of-the-clinical-characteristics-and-comprehensive-assessments-of-the-2011-and-2017-gold-classifications-for-patients-with-copd-in-china
#10
Yu-He Hu, Zhen-Yu Liang, Li-Mei Xu, Wen-Hui Xu, Hao Liao, Rui Li, Kai Wang, Ying Xu, Chun-Quan Ou, Xin Chen
Objective: Compared with the 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD), there have been significant changes in the 2017 GOLD classification. The purpose of this study was to analyze the changes in clinical characteristics of the new A-B-C-D system and to explore its role in comprehensive assessment of COPD. Subjects and methods: A total of 631 stable COPD patients were included in a cross-sectional survey. Data collected included baseline data and pulmonary function testing results, respiratory muscle strength, symptoms and quality of life, exercise capacity, nutritional status, and anxiety and depression as a comprehensive assessment...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319248/current-appraisal-of-single-inhaler-triple-therapy-in-copd
#11
EDITORIAL
Brian Lipworth, Chris RuiWen Kuo, Sunny Jabbal
A single inhaler containing inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA)/long-acting muscarinic antagonist (LAMA) is a more convenient way of delivering triple therapy in patients with COPD. Single triple therapy has been shown to be superior at reducing exacerbations and improving quality of life compared to LABA/LAMA, especially in patients with a prior history of frequent exacerbations and blood eosinophilia, who have ICS responsive disease. The corollary is that patients with infrequent exacerbations who are noneosinophilic may be safely de-escalated from triple therapy to LABA/LAMA without loss of control...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30319247/longitudinal-stability-of-blood-eosinophil-count-strata-in-the-copd-cosyconet-cohort
#12
Timm Greulich, Sina Mager, Tanja Lucke, Andreas Rembert Koczulla, Robert Bals, Sebastian Fähndrich, Rudolf A Jörres, Peter Alter, Anne Kirsten, Claus Franz Vogelmeier, Henrik Watz
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30310274/-1-h-nmr-based-metabolic-profiling-of-healthy-individuals-and-high-resolution-ct-classified-phenotypes-of-copd-with-treatment-of-tiotropium-bromide
#13
Li-Chuan Tan, Wen-Jie Yang, Wei-Ping Fu, Ping Su, Jing-Kui Shu, Lu-Ming Dai
Background: Heterogeneity of COPD results in different therapeutic effects for different patients receiving the same treatment. COPD patients need to be individually treated according to their own characteristics. The purpose of this study was to explore the differences in different CT phenotypic COPD by molecular metabolites through the use of metabolomics. Methods: According to the characteristics of CT imaging, 42 COPD patients were grouped into phenotype E (n=20) or phenotype M (n=24)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30310273/improved-lung-function-and-patient-reported-outcomes-with-co-suspension-delivery-technology-glycopyrrolate-formoterol-fumarate-metered-dose-inhaler-in-copd-a-randomized-phase-iii-study-conducted-in-asia-europe-and-the-usa
#14
Brian J Lipworth, David J Collier, Yasuhiro Gon, Nanshan Zhong, Koichi Nishi, Rongchang Chen, Samir Arora, Andrea Maes, Shahid Siddiqui, Colin Reisner, Ubaldo J Martin
Background: COPD is a major global cause of mortality and morbidity. PINNACLE-4 evaluated the efficacy and safety of GFF MDI (glycopyrrolate/formoterol fumarate metered dose inhaler) in patients from Asia, Europe, and the USA with moderate-to-very severe COPD. Methods: In this double-blind, placebo-controlled, Phase III study, patients were randomized to treatment with GFF MDI 18/9.6 μg, glycopyrrolate (GP) MDI 18 μg, formoterol fumarate (FF) MDI 9.6 μg, or placebo MDI (all twice daily) for 24 weeks...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30310272/bispectral-index-in-hypercapnic-encephalopathy-associated-with-copd-exacerbation-a-pilot-study
#15
Roberto Chalela, Lluis Gallart, Sergi Pascual-Guardia, Antonio Sancho-Muñoz, Joaquim Gea, Mauricio Orozco-Levi
Background: Hypercapnic encephalopathy is relatively frequent in severe exacerbations of COPD (ECOPDs), with its intensity usually being evaluated through clinical scales. Bispectral index (BIS) is a relatively new technique, based on the analysis of the electroencephalographic signal, which provides a good approximation to the level of consciousness, having already been validated in anesthesia. Objective: The objective of the study was to evaluate the utility of BIS in the assessment of the intensity of hypercapnic encephalopathy in ECOPD patients...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30310271/the-impact-of-2011-and-2017-global-initiative-for-chronic-obstructive-pulmonary-disease-gold-guidelines-on-allocation-and-pharmacological-management-of-patients-with-copd-in-taiwan-taiwan-obstructive-lung-disease-told-study
#16
Meng-Jer Hsieh, Shu-Yi Huang, Tsung-Ming Yang, Chi-Wei Tao, Shih-Lung Cheng, Chao-Hsien Lee, Ping-Hung Kuo, Yao-Kuang Wu, Ning-Hung Chen, Wu-Huei Hsu, Jeng-Yuan Hsu, Ming-Shian Lin, Chin-Chou Wang, Yu-Feng Wei, Ying-Huang Tsai
Background: This nationwide study was performed to evaluate the evolution of distributions of patients with COPD according to the 2011 and 2017 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines and to assess the concordance between the prescribed medications and the pharmacological management recommended by the two distinct classification systems in Taiwan. Subjects and methods: Data were retrospectively retrieved from stable COPD patients in 11 participating hospitals across Taiwan...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30288037/a-comparative-analysis-of-errors-in-inhaler-technique-among-copd-versus-asthma-patients
#17
Birsen Ocakli, Ipek Ozmen, Eylem Acartürk Tunçay, Sinem Gungor, Hilal Altinoz, Nalan Adiguzel, Zafer Ali Sak, Gokay Gungor, Zuhal Karakurt, Peri Arbak
Purpose: This study was designed to evaluate errors in inhaler technique in COPD vs asthma patients and to investigate the association of poor inhaler technique with patient demographics and clinical variables. Patients and methods: A total of 509 adult patients with COPD (n=328) or asthma (n=181) who were currently using an inhaler device were included in this study. Data on patient demographics, duration of disease, type and duration of inhaler therapy, and assessment of inhaler technique were recorded...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30275691/the-role-of-plasma-n-terminal-brain-natriuretic-pro-peptide-in-diagnosing-elderly-patients-with-acute-exacerbation-of-copd-concurrent-with-left-heart-failure
#18
Xuxue Guo, Hanxiang Nie, Qianhui Chen, Shuo Chen, Nishan Deng, Ruiyun Li, Xuhong Ding, Suping Hu, Ailing Wang
Introduction: Acute exacerbation of COPD (AECOPD) and left heart failure (LHF) commonly exist together in clinical practice. However, the identification of AECOPD concurrent with LHF is currently challenging. Our study aimed to investigate the role of plasma N-terminal brain natriuretic pro-peptide (NT-proBNP) in diagnosing elderly patients with AECOPD associated with LHF. Methods and results: LHF was diagnosed in patients with AECOPD according to echocardiographic criteria, and the levels of NT-proBNP in plasma were measured by quantitative electrochemiluminescence assay...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30275690/effect-of-background-long-acting-beta-2-agonist-therapy-on-the-efficacy-and-safety-of-a-novel-nebulized-glycopyrrolate-in-subjects-with-moderate-to-very-severe-copd
#19
Edward M Kerwin, Robert Tosiello, Barry Price, Shahin Sanjar, Thomas Goodin
Background: Phase III studies demonstrated efficacy and safety of nebulized glycopyrrolate inhalation solution (GLY) in subjects with COPD. Secondary analyses were performed to examine the effect of background long-acting beta2 -agonist (LABA) use on the efficacy and safety of nebulized GLY. Methods: In two 12-week placebo-controlled studies (GOLDEN 3 and GOLDEN 4) and one 48-week, open-label active-controlled study (GOLDEN 5), a total of 2,379 subjects were stratified by background LABA use (LABA-yes: n=861; LABA-no: n=1,518) and randomized to placebo vs GLY 25 or 50 µg twice daily, or GLY 50 µg twice daily vs tiotropium (TIO) 18 µg once daily...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30275689/proton-pump-inhibitors-use-is-associated-with-a-lower-risk-of-acute-exacerbation-and-mortality-in-patients-with-coexistent-copd-and-gerd
#20
Vincent Yi-Fong Su, Han-Fang Liao, Diahn-Warng Perng, Yueh-Ching Chou, Chia-Chen Hsu, Chia-Lin Chou, Yuh-Lih Chang, Jiin-Cherng Yen, Tzeng-Ji Chen, Ting-Chun Chou
Objective: The effect of antacid therapy for patients with COPD and gastroesophageal reflux disease (GERD) remains unclear. Patients and methods: This nationwide population-based study was conducted using data from Taiwan's National Health Insurance Research Database, and enrolled COPD patients with or without GERD. Patients with COPD who were not prescribed COPD medications were excluded. Patients with GERD who underwent upper gastrointestinal endoscopy or 24-hour pH monitoring and received at least 1 antacid were enrolled as symptomatic GERD group...
2018: International Journal of Chronic Obstructive Pulmonary Disease
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