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International Journal of Chronic Obstructive Pulmonary Disease

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https://www.readbyqxmd.com/read/29681729/risk-factors-for-respiratory-hospitalizations-in-a-population-of-patients-with-a-clinical-diagnosis-of-copd
#1
Jovica Veljanovski, Daniel R Ouellette
Purpose: The purpose of this study was to examine differences between patients clinically diagnosed with COPD with and without obstruction by spirometry and to identify risk factors for respiratory hospitalizations. Materials and methods: This is a retrospective analysis of all patients diagnosed with COPD at a large academic Internal Medicine Clinic in 2014, who had spirometry performed during the period 2013-2014. Two groups existed: one with obstruction termed classical COPD and another without obstruction...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29681728/harmful-impact-of-air-pollution-on-severe-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-particulate-matter-is-hazardous
#2
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Jae Jeong Shim
Introduction: Particulate matter and air pollution in Korea are becoming worse. There is a lack of research regarding the impact of particulate matter on patients with COPD. Therefore, the purpose of this study was to investigate the effects of various air pollution factors, including particulate matter, on the incidence rate of severe acute exacerbations of COPD (AECOPD) events. Methods: We analyzed the relationship between air pollutants and AECOPD events that required hospitalization at Guro Hospital in Korea from January 1, 2015 to May 31, 2017...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29670346/prediction-of-severe-exacerbations-and-mortality-in-copd-the-role-of-exacerbation-history-and-inspiratory-capacity-total-lung-capacity-ratio
#3
João Cardoso, Ricardo Coelho, Carla Rocha, Constança Coelho, Luísa Semedo, A Bugalho Almeida
Background: Severe exacerbations and mortality are major outcomes in COPD, and risk factors for these events are actively searched for. Several predictors of mortality have been identified in COPD. The inspiratory capacity/total lung capacity (IC/TLC) ratio has been shown to be a strong predictor of all cause and respiratory mortality in patients with COPD. The major objectives of this study were to analyze which clinical parameters, including lung volumes, were the best predictors of the 5-year cumulative risk of hospital admissions or death and the 5-year risk of exacerbations, in stable COPD patients...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29670345/practical-considerations-when-prescribing-a-long-acting-muscarinic-antagonist-for-patients-with-copd
#4
REVIEW
Anthony D D'Urzo, Peter Kardos, Russell Wiseman
COPD is characterized by persistent airflow limitation, progressive breathlessness, cough, and sputum production. Long-acting muscarinic antagonists (LAMAs) are one of the recommended first-choice therapeutic options for patients with COPD, and several new agents have been developed in recent years. A literature search identified 14 published randomized, placebo-controlled studies of the efficacy and safety of LAMAs in patients with COPD, with improvements seen in lung function, exacerbations, breathlessness, and health status...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29670344/cost-effectiveness-analysis-of-a-fixed-dose-combination-of-indacaterol-and-glycopyrronium-as-maintenance-treatment-for-copd
#5
Ming-Cheng Chan, Elise Chia-Hui Tan, Ming-Chin Yang
Objective: The aim of this study was to evaluate the cost-effectiveness of the long-acting beta-2 agonist (LABA)/long-acting muscarinic antagonist (LAMA) dual bronchodilator indacaterol/glycopyrronium (IND/GLY) as a maintenance treatment for COPD patients from the perspective of health care payer in Taiwan. Patients and methods: We adopted a patient-level simulation model, which included a cohort of COPD patients aged ≥40 years. The intervention used in the study was the treatment using IND/GLY, and comparators were tiotropium or salmeterol/fluticasone combination (SFC)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29662309/description-of-nighttime-cough-epochs-in-patients-with-stable-copd-gold-ii-iv
#6
Patrick Fischer, Volker Gross, Johannes Kroenig, Andreas Weissflog, Olaf Hildebrandt, Keywan Sohrabi, Ulrich Koehler
Purpose: Chronic cough is one of the main symptoms of COPD. Ambulatory objective monitoring provides novel insights into the determinants and characteristics of nighttime cough in COPD. Materials and methods: Nighttime cough was monitored objectively by LEOSound lung sound monitor in patients with stable COPD II-IV. In 30 patients, with 10 patients in each stage group, nighttime cough was analyzed for epoch frequency, epoch severity (epoch length and coughs per epoch), and pattern (productive or nonproductive)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29628761/respiratory-parameters-predict-poor-outcome-in-copd-patients-category-gold-2017-b
#7
Kristian Brat, Marek Plutinsky, Karel Hejduk, Michal Svoboda, Patrice Popelkova, Jaromir Zatloukal, Eva Volakova, Miroslava Fecaninova, Lucie Heribanova, Vladimir Koblizek
Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29628760/support-needs-of-patients-with-copd-a-systematic-literature-search-and-narrative-review
#8
REVIEW
A Carole Gardener, Gail Ewing, Isla Kuhn, Morag Farquhar
Introduction: Understanding the breadth of patients' support needs is important for the delivery of person-centered care, particularly in progressive long-term conditions such as chronic obstructive pulmonary disease (COPD). Existing reviews identify important aspects of managing life with COPD with which patients may need support (support needs); however, none of these comprehensively outlines the full range of support needs that patients can experience. We therefore sought to systematically determine the full range of support needs for patients with COPD to inform development of an evidence-based tool to enable person-centered care...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29628759/the-development-of-azd7624-for-prevention-of-exacerbations-in-copd-a-randomized-controlled-trial
#9
Naimish R Patel, Danen M Cunoosamy, Malin Fagerås, Ziad Taib, Sara Asimus, Tove Hegelund-Myrbäck, Sofia Lundin, Katerina Pardali, Nisha Kurian, Eva Ersdal, Cecilia Kristensson, Katarina Korsback, Robert Palmér, Mary N Brown, Steven Greenaway, Leonard Siew, Graham W Clarke, Stephen I Rennard, Barry J Make, Robert A Wise, Paul Jansson
Background: p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation and activation of pro-inflammatory mediators. COPD patients have increased levels of activated p38 MAPK, which correlate with increased lung function impairment, alveolar wall inflammation, and COPD exacerbations. Objectives: These studies aimed to assess the effect of p38 inhibition with AZD7624 in healthy volunteers and patients with COPD. The principal hypothesis was that decreasing lung inflammation via inhibition of p38α would reduce exacerbations and improve quality of life for COPD patients at high risk for acute exacerbations...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29615836/long-term-evolution-of-lung-function-in-individuals-with-alpha-1-antitrypsin-deficiency-from-the-spanish-registry-redaat
#10
Cristina Esquinas, Sonia Serreri, Miriam Barrecheguren, Esther Rodriguez, Alexa Nuñez, Francisco Casas-Maldonado, Ignacio Blanco, Pietro Pirina, Beatriz Lara, Marc Miravitlles
Background: The clinical course of alpha-1 antitrypsin deficiency (AATD) is very heterogeneous. It is estimated that 60% of individuals with severe AATD (Pi*ZZ) develop emphysema. The main objective of this study was to describe the outcomes of long-term lung function in individuals with AATD-associated emphysema after at least 8 years of follow-up. Materials and methods: We performed a retrospective analysis of longitudinal follow-up data of AATD PiZZ patients from the Spanish registry (AATD Spanish Registry [REDAAT])...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29615835/the-effect-of-electronic-cigarette-and-tobacco-smoke-exposure-on-copd-bronchial-epithelial-cell-inflammatory-responses
#11
Andrew Higham, Declan Bostock, George Booth, Josiah V Dungwa, Dave Singh
Background: Electronic cigarettes (e-cigs) are used to help smoking cessation. However, these devices contain harmful chemicals, and there are safety concerns. We have investigated the effects of e-cigs on the inflammatory response and viability of COPD bronchial epithelial cells (BECs). Methods: BECs from COPD patients and controls were exposed to e-cig vapor extract (ECVE) and the levels of interleukin (IL)-6, C-X-C motif ligand 8 (CXCL8), and lactate dehydrogenase release were measured...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29606865/long-term-oxygen-therapy-in-copd-patients-population-based-cohort-study-on-mortality
#12
Nikolay Pavlov, Alan Gary Haynes, Armin Stucki, Peter Jüni, Sebastian Robert Ott
Purpose: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is associated with a growing and substantial socioeconomic burden. Long-term oxygen therapy (LTOT), recommended by current treatment guidelines for COPD patients with severe chronic hypoxemia, has shown to reduce mortality in this population. The aim of our study was to assess the standardized mortality ratios of incident and prevalent LTOT users and to identify predictors of mortality...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29606864/do-patients-and-carers-agree-on-symptom-burden-in-advanced-copd
#13
Emma Mi, Ella Mi, Gail Ewing, Patrick White, Ravi Mahadeva, A Carole Gardener, Morag Farquhar
Objective: Accurate informal carer assessment of patient symptoms is likely to be valuable for decision making in managing the high symptom burden of COPD in the home setting. Few studies have investigated agreement between patients and carers in COPD. We aimed to assess agreement between patients and carers on symptoms, and factors associated with disagreement in a population-based sample of patients with advanced COPD. Patients and methods: This was a prospective, cross-sectional analysis of data from 119 advanced COPD patients and their carers...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29606863/cigarette-smoke-exposure-promotes-differentiation-of-cd4-t-cells-toward-th17-cells-by-cd40-cd40l-costimulatory-pathway-in-mice
#14
Yi Liang, Ying Shen, Liangjian Kuang, Guang Zhou, Longju Zhang, Xiaoning Zhong, Jianquan Zhang, Jifeng Liu
Purpose: This study aimed to investigate the impact of cigarette smoke exposure upon CD40-CD40L ligation between bone marrow-derived dendritic cells (BMDCs)and CD4+ T cells, and to examine the effects of cigarette smoke exposure upon differentiation of CD4+ T cells toward Th17 cells through blockade of CD40-CD40L pathway in mice. Methods: The study was processed in vivo and in vitro. In vivo, Th17 cells, CD40, interleukin (IL)-17A, and IL-27 in the lung tissues were quantified and compared between mice with and without cigarette smoke exposure...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29606862/a-high-copd-assessment-test-score-may-predict-anxiety-in-copd
#15
Hilman Harryanto, Sally Burrows, Yuben Moodley
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29606861/pharmacokinetics-of-glycopyrronium-formoterol-fumarate-dihydrate-delivered-via-metered-dose-inhaler-using-co-suspension-delivery-technology-in-patients-with-moderate-to-very-severe-copd
#16
Gary T Ferguson, Roberto Rodriguez-Roisin, Colin Reisner, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin
Purpose: The efficacy and tolerability of GFF MDI (Bevespi Aerosphere® ), a fixed-dose combination of glycopyrronium (GP)/formoterol fumarate dihydrate (FF) 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler (MDI) using innovative co-suspension delivery technology, has been investigated in a Phase III clinical trial program (NCT01854645, NCT01854658, NCT01970878) in patients with COPD. Here, we present findings from a pharmacokinetic (PK) sub-study of NCT01854645 (PINNACLE-1)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29593386/lack-of-association-between-airflow-limitation-and-recurrence-of-venous-thromboembolism-among-cancer-patients-with-pulmonary-embolism
#17
Sun Hye Shin, Danbee Kang, Juhee Cho, Haseong Chang, Min Sun Kim, Su Yeon Lee, Hyun Lee, Hojoong Kim, Duk-Kyung Kim, Eun Kyoung Kim, Hye Yun Park
Background: COPD is a well-known risk factor for venous thromboembolism (VTE) development. However, recent data showed that it was not associated with VTE recurrence risk, which excluded cancer patients. This study investigated the association of airflow limitation and VTE recurrence in cancer patients with pulmonary embolism (PE). Methods: This is a retrospective cohort study of cancer patients with newly diagnosed PE at a university hospital. PE was confirmed using contrast-enhanced computed tomography scan...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29588581/maintenance-inhaler-preference-attribute-importance-and-satisfaction-in-prescribing-physicians-and-patients-with-asthma-copd-or-asthma-copd-overlap-syndrome-consulting-for-routine-care
#18
Bo Ding, Mark Small, Gina Scheffel, Ulf Holmgren
Background: In respiratory disorders, patient- and physician-perceived satisfaction with the maintenance inhaler device is an important factor driving treatment compliance and outcomes. We examine inhaler preferences in asthma and COPD from patient and physician perspectives, particularly focusing on the relative importance of individual device attributes and patient characteristics guiding inhaler choice. Materials and methods: Real-world data from >7,300 patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS) consulting for routine care were derived from respiratory Disease Specific Programs conducted in Europe, USA, Japan, and China...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29588580/a-functional-snp-upstream-of-the-adrb2-gene-is-associated-with-copd
#19
Jin-Xiu Li, Wei-Ping Fu, Jing Zhang, Xiao-Hua Zhang, Chang Sun, Lu-Ming Dai, Li Zhong, Li Yu, Ya-Ping Zhang
Background: Previous studies have suggested that β2 -adrenergic receptor ( ADRB2 ) is associated with COPD. However, the role of genetic polymorphisms in ADRB2 on COPD has not been evaluated yet. Methods: In this study, SNaPshot genotyping, luciferase assay, chromatin immunoprecipitation and real-time polymerase chain reaction were adopted to investigate the association between ADRB2 genetic polymorphisms and COPD, comprehensively. Results: One single nucleotide polymorphism (rs12654778), located upstream of ADRB2 , showed a significant association with COPD by the logistic regression analysis after adjusting for age, sex and smoking history ( p =0...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29578541/perspectives-on-narrative-medicine
#20
COMMENT
Amir-Seena Saberi-Movahed, Syed Waqar, Ahmad Salha
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
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