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International Journal of Chronic Obstructive Pulmonary Disease

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https://www.readbyqxmd.com/read/30519014/mitochondrial-functioning-abnormalities-observed-in-blood-platelets-of-chronic-smoke-exposed-guinea-pigs-a-pilot-study
#1
Adam J Białas, Karolina Siewiera, Cezary Watała, Anna Rybicka, Bartłomiej Grobelski, Leon Kośmider, Jolanta Kurek, Joanna Miłkowska-Dymanowska, Wojciech J Piotrowski, Paweł Górski
Background: COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. A considerable body of evidence suggests that cardiovascular risk is elevated by the activation of blood platelets, which in turn is exacerbated by inflammation. As reactive oxygen species are believed to be an important factor in platelet metabolism and functioning, the aim of our study was to perform a complex assessment of mitochondrial function in platelets in chronic smoke exposed animals with COPD-like lung lesions...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30519013/the-association-of-elevated-circulating-endocan-levels-with-lung-function-decline-in-copd-patients
#2
Luqi Dai, Junyun He, Jun Chen, Tao Wang, Lian Liu, Yongchun Shen, Lei Chen, Fuqiang Wen
Background: Endocan is thought to be a novel inflammatory marker that is associated with a variety of inflammatory diseases. However, its role in the pathogenesis of COPD remains unclear. This study aims to explore the potential role of endocan in COPD. Methods: In total, 27 healthy volunteers, 55 COPD patients and 36 acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients were included in the study. Basic demographic characteristics, clinical features and blood samples were collected...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30510411/lung-function-and-ct-lung-densitometry-in-37-to-39-year-old-individuals-with-alpha-1-antitrypsin-deficiency
#3
Behrouz Mostafavi, Sandra Diaz, Eeva Piitulainen, Berend C Stoel, Per Wollmer, Hanan A Tanash
Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to emphysema. A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was identified by the Swedish national neonatal AAT screening program in 1972-1974 and has been followed-up since birth. Our aim was to study whether the cohort has signs of emphysema in pulmonary function tests (PFTs) and computed tomography (CT) densitometry at 38 years of age in comparison with an age-matched control group, randomly selected from the population registry...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30510410/effects-of-a-copd-self-management-support-intervention-a-randomized-controlled-trial
#4
Heidi B Bringsvor, Eva Langeland, Bjørg Frøysland Oftedal, Knut Skaug, Jörg Assmus, Signe Berit Bentsen
Background: This study examines the effects of the COPD-specific health promoting self-management intervention "Better living with COPD" on different self-management-related domains, self-efficacy, and sense of coherence (SOC). Methods: In a randomized controlled design, 182 people with COPD were allocated to either an intervention group (offered Better living with COPD in addition to usual care) or a control group (usual care). Self-management-related domains were measured by the Health Education Impact Questionnaire (heiQ) before and after intervention...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30510409/sputum-moraxella-catarrhalis-strains-exhibit-diversity-within-and-between-copd-subjects
#5
Leena M George, Richard D Haigh, Vijay Mistry, Koirobi Haldar, Michael R Barer, Marco R Oggioni, Christopher E Brightling
Purpose: Moraxella catarrhalis is implicated in the pathogenesis of some COPD exacerbations. We sought to investigate whether the M. catarrhalis strain is variable between COPD subjects; that an exacerbation is associated with acquisition of a new strain and that certain strains are more commonly associated with exacerbations. Patients and methods: Sputum samples were collected at stable and exacerbation visits from COPD subjects from a single center as part of the COPDMAP consortium...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498343/the-dose-of-inhaled-corticosteroids-in-patients-with-copd-when-less-is-better
#6
REVIEW
José Luis Izquierdo, Borja G Cosio
Background: The use of inhaled corticosteroids (ICS) in combination with bronchodilators in patients with COPD has been shown to decrease the rate of disease exacerbations and to improve the lung function and patients' quality of life. However, their use has also been associated with an increased risk of pneumonia. Materials and methods: We have reviewed existing clinical evidence on the risks and benefits of ICS in COPD, including large randomized clinical trials, meta-analyses, and clinical reviews...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498342/the-likelihood-of-improving-physical-activity-after-pulmonary-rehabilitation-is-increased-in-patients-with-copd-who-have-better-exercise-tolerance
#7
Christian R Osadnik, Matthias Loeckx, Zafeiris Louvaris, Heleen Demeyer, Daniel Langer, Fernanda M Rodrigues, Wim Janssens, Ioannis Vogiatzis, Thierry Troosters
Purpose: Pulmonary rehabilitation (PR) enhances exercise tolerance in patients with COPD; however, improvements in physical activity (PA) are not guaranteed. This study explored the relationship between baseline exercise tolerance and changes in PA after PR. Materials and methods: Patient data from prospective clinical trials in the PR settings of Athens and Leuven (2008-2016) were analyzed. Validated PA monitors were worn for 1 week before and after a 12-week program...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498341/bronchodilator-responsiveness-or-reversibility-in-asthma-and-copd-a-need-for-clarity
#8
EDITORIAL
Igor Barjaktarevic, Robert Kaner, Russell G Buhr, Christopher B Cooper
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498340/inhaled-corticosteroids-might-not-increase-the-risk-of-pneumonia-in-patients-with-chronic-obstructive-pulmonary-disease-in-japan
#9
Ryosuke Hirano, Masaki Fujita, Takemasa Matsumoto, Rintaro On, Kentaro Watanabe
Background: The use of inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD) decreases the frequency of COPD exacerbations. Recently, pneumonia was reported as a complication of ICS in patients with COPD. However, there have been few reports concerning the relationship between ICS and pneumonia in Japan. Moreover, there is little information on the types of ICS. Patients and methods: To clarify these issues, we investigated the occurrence of pneumonia in Japanese patients with COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498339/increased-vulnerability-of-copd-patient-groups-to-urban-climate-in-view-of-global-warming
#10
Christina Hoffmann, Marc Hanisch, Jana B Heinsohn, Vanessa Dostal, Melissa Jehn, Uta Liebers, Wulf Pankow, Gavin C Donaldson, Christian Witt
Purpose: Patients with COPD show an increase in acute exacerbations (AECOPD) during the cold season as well as during heat waves in the summer months. Due to global climate changes, extreme weather conditions are likely to occur more frequently in the future. The goal of this study was to identify patient groups most at risk of exacerbations during the four seasons of the year and to determine at which temperature threshold the daily hospital admissions due to AECOPD increase during the summer...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498338/what-is-the-impact-of-gold-2017-recommendations-in-primary-care-a-descriptive-study-of-patient-classifications-treatment-burden-and-costs
#11
Alicia Gayle, Scott Dickinson, Kevin Morris, Chris Poole, Alexander G Mathioudakis, Jørgen Vestbo
Purpose: The changes in grading of disease severity and treatment recommendations for patients with COPD in the 2017 GOLD strategy may present an opportunity for reducing treatment burden for the patients and costs to the health care system. The aim of this study was to assess the implications of the GOLD 2017 grading system in terms of change in distribution across GOLD groups A-D for existing patients in UK primary care and estimate the potential cost savings of implementing GOLD 2017 treatment recommendations in UK primary care...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30498337/clinical-impacts-of-the-classification-by-2017-gold-guideline-comparing-previous-ones-on-outcomes-of-copd-in-real-world-cohorts
#12
Jin Hwa Song, Chang-Hoon Lee, Soo-Jung Um, Yong Bum Park, Kwang Ha Yoo, Ki Suck Jung, Sang-Do Lee, Yon-Mok Oh, Ji Hyun Lee, Eun Kyung Kim, Deog Kyeom Kim
Purpose: While GOLD classification has been revised, its clinical impacts on outcomes of COPD patients have not been widely evaluated in real-world cohorts. Materials and methods: According to 2007, 2013, and 2017 GOLD classifications, distribution and clinical characteristics of group-shifted patients and the risk of acute exacerbation were analyzed in combined Korean COPD cohorts. Future risk for annual moderate-to-severe exacerbation was estimated as incidence rate ratio (IRR) and compared by groups...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464449/blood-eosinophils-a-biomarker-of-copd-exacerbation-reduction-with-inhaled-corticosteroids
#13
Salman H Siddiqui, Ian D Pavord, Neil C Barnes, Alessandro Guasconi, Sally Lettis, Steven Pascoe, Stefano Petruzzelli
Background: Growing evidence suggests that blood eosinophil count is associated with patient responsiveness to inhaled corticosteroids (ICS). We performed post hoc predictive modeling on data from the FORWARD study and two replicate studies by Dransfield, to evaluate the relationships between baseline eosinophil count and the effect of ICS on exacerbations and lung function in patients with COPD. Methods: The studies assessed ICS/long-acting β2 agonist (LABA) combinations vs LABA alone...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464448/defining-the-role-of-neutrophil-to-lymphocyte-ratio-in-copd-a-systematic-literature-review
#14
REVIEW
Yuliana Pascual-González, Marta López-Sánchez, Jordi Dorca, Salud Santos
COPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464447/endobronchial-coil-treatment-in-severe-emphysema-patients-with-alpha-1-antitrypsin-deficiency
#15
Jeanne Marie Perotin, Sylvie Leroy, Charles Hugo Marquette, Hervé Mal, Hervé Dutau, Arnaud Bourdin, Jean Michel Vergnon, Christophe Pison, Coralie Barbe, Gaëtan Deslee
Endobronchial coil treatment (ECT) is a minimally invasive procedure developed for palliative care of patients with severe emphysema. ECT has demonstrated a decrease in hyperinflation, an improvement in quality of life, and an acceptable safety profile in randomized controlled trials (RCTs). Because alpha-1 antitrypsin deficiency (AATD) is a classical exclusion criterion in RCTs, there is no available data for ECT in AATD. In this post hoc analysis of the REVOLENS study (Réduction volumique endobronchique par spirales; ClinicalTrials...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464446/nasal-high-flow-but-not-supplemental-o-2-reduces-peripheral-vascular-sympathetic-activity-during-sleep-in-copd-patients
#16
K Fricke, H Schneider, P Biselli, N N Hansel, Z G Zhang, M O Sowho, L Grote
Introduction: Patients with COPD have increased respiratory loads and altered blood gases, both of which affect vascular function and sympathetic activity. Sleep, particularly rapid eye movement (REM) sleep, is known to exacerbate hypoxia and respiratory loads. Therefore, we hypothesize that nasal high flow (NHF), which lowers ventilatory loads, reduces sympathetic activity during sleep and that this effect depends on COPD severity. Methods: We performed full polysomnography in COPD patients (n=17; FEV1 , 1...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464445/improvement-in-hypercapnia-does-not-predict-survival-in-copd-patients-on-chronic-noninvasive-ventilation
#17
Tim Raveling, Gerrie Bladder, Judith M Vonk, Jellie A Nieuwenhuis, Fransien M Verdonk-Struik, Peter J Wijkstra, Marieke L Duiverman
Purpose: It has recently been shown that chronic noninvasive ventilation (NIV) improves a number of outcomes including survival, in patients with stable hypercapnic COPD. However, the mechanisms responsible for these improved outcomes are still unknown. The aim of the present study was to identify parameters associated with: 1) an improved arterial partial pressure of carbon dioxide (PaCO2 ) and 2) survival, in a cohort of hypercapnic COPD patients treated with chronic NIV. Patients and methods: Data from 240 COPD patients treated with chronic NIV were analyzed...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464444/cholinergic-mechanisms-in-an-organic-dust-model-simulating-an-acute-exacerbation-in-patients-with-copd
#18
Lena Palmberg, Britt-Marie Sundblad, Jie Ji, Jakob Karén, Kjell Larsson
Background: Exposure in a pig barn induces airway inflammation that has similarities with the response observed in acute exacerbations in COPD. Methods: A total of 15 smokers with COPD and 15 healthy non-smokers were exposed for 2 hours in a pig barn (in vivo exposure). Symptoms were assessed, lung function measured, and blood and sputum samples taken before and after exposure. Blood neutrophils were isolated and stimulated ex vivo with dust from a pig barn and acetylcholine, and inflammatory markers were analyzed...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464443/exercise-capacity-in-copd-patients-with-exercise-induced-pulmonary-hypertension
#19
Ingunn Skjørten, Janne Mykland Hilde, Morten Nissen Melsom, Jonny Hisdal, Viggo Hansteen, Kjetil Steine, Sjur Humerfelt
Background: Pulmonary hypertension (PH) in patients with COPD is associated with reduced exercise capacity. A subgroup of COPD patients has normal mean pulmonary artery pressure (mPAP) at rest, but develops high mPAP relative to cardiac output (CO) during exercise, a condition we refer to as exercise-induced pulmonary hypertension (EIPH). We hypothesized that COPD patients with EIPH could be identified by cardiopulmonary exercise test (CPET) and that these patients have lower exercise capacity and more abnormal CPET parameters compared to COPD patients with normal hemodynamic exercise response...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30464442/erratum-the-impact-of-dual-bronchodilation-on-cardiovascular-serious-adverse-events-and-mortality-in-copd-a-quantitative-synthesis-corrigendum
#20
(no author information available yet)
[This corrects the article on p. 3469 in vol. 12, PMID: 29255354.].
2018: International Journal of Chronic Obstructive Pulmonary Disease
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