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International Journal of Chronic Obstructive Pulmonary Disease

Wassim W Labaki, MeiLan K Han
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
Marco Mantero, Dejan Radovanovic, Pierachille Santus, Francesco Blasi
The major determinant of the decline in lung function, quality of life, and the increased mortality risk in patients with COPD is represented by severe acute exacerbations of the disease, that is, those requiring patients' hospitalization, constituting a substantial social and health care burden in terms of morbidity and medical resource utilization. Different long-term therapeutic strategies have been proposed so far in order to prevent and/or reduce the clinical and social impact of these events, the majority of which were extrapolated from trials initially focused on the effect of long-acting muscarinic antagonist and subsequently on the efficacy of long-acting β2-agonists in combination or not with inhaled corticosteroids...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Adam J Białas, Paweł P Liberski, Anna Zielińska, Anna Kumor-Kisielewska, Karolina Szewczyk, Joanna Miłkowska-Dymanowska, Przemysław Sitarek, Wojciech J Piotrowski, Paweł Górski
Introduction: Exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events in the course of the disease, negatively influencing health status and disease progression. Therefore, there is a strong need for deeper understanding of the pathology of ECOPD to elaborate new therapeutic approaches and ameliorate prognoses. Contributions of mitochondria to pathobiology of COPD are still under investigation, although growing evidence suggests their important role in this disease...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jeetvan G Patel, Anna D Coutinho, Orsolya E Lunacsek, Anand A Dalal
Purpose: This study aimed to measure the true burden of COPD by calculating incremental direct and indirect costs. Direct medical resource use, productivity metrics, and COPD-specific resource use and costs were also evaluated. Patients and methods: This was a retrospective, observational, matched cohort study using administrative claims data from the Truven Health MarketScan® Commercial Claims and Encounters and the Health and Productivity Management databases (2007-2010)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Wenqi Diao, Ning Shen, Yipeng Du, John R Erb-Downward, Xiaoyan Sun, Chenxia Guo, Qian Ke, Gary B Huffnagle, Margaret R Gyetko, Bei He
Background: The role of airway microbiota in COPD is highly debated. Symptomology assessment is vital for the management of clinically stable COPD patients; however, the link between symp toms and the airway microbiome is currently unknown. Purpose: The present study aimed to evaluate the relationship among stable COPD patients. Patients and methods: We conducted pyrosequencing of bacterial 16S rRNA using induced sputum samples in a Han Chinese cohort that included 40 clinically stable COPD patients and 19 healthy controls...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jose Luis Lopez-Campos, Bernardino Alcázar Navarrete, Joan B Soriano, Juan J Soler-Cataluña, José Miguel Rodríguez González-Moro, Manuel E Fuentes Ferrer, Myriam Calle Rubio
Purpose: Current COPD management recommendations indicate that pharmacological treatment can be stepped up or down, but there are no recommendations on how to make this adjustment. We aimed to describe pharmacological prescriptions during a routine clinical visit for COPD and study the determinants of changing therapy. Methods: EPOCONSUL is a Spanish nationwide observational cross-sectional clinical audit with prospective case recruitment including 4,508 COPD patients from outpatient respiratory clinics for a period of 12 months (May 2014-May 2015)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Swati Gulati, Aline N Zouk, Jonathan P Kalehoff, Christopher S Wren, Peter N Davison, Denay Porter Kirkpatrick, Surya P Bhatt, Mark T Dransfield, James Michael Wells
Background: Systemic corticosteroids (SC) are an integral part of managing acute exacerbations of COPD (AECOPD). However, the optimal dose and duration vary widely in clinical practice. We hypothesized that the use of a "PowerPlan" order set in the electronic health system (EHS) that includes a 5-day SC order would be associated with a reduced steroid dose and length of stay (LOS) for individuals hospitalized with AECOPD. Patients and methods: We conducted a retrospective cohort study of Medicare recipients discharged with an AECOPD diagnosis from our University Hospital from 2014 to 2016...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Yong Suk Jo, Yee Hyung Kim, Jung Yeon Lee, Kyungjoo Kim, Ki-Suck Jung, Kwang Ha Yoo, Chin Kook Rhee
Background and objective: The rate of obesity is increasing in Asia, but the clinical impact of body mass index (BMI) on the outcome of chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to assess this impact while focusing on the risk of exacerbation, health-care utilization, and medical costs. Methods: We examined 43,864 subjects registered in the Korean National Health and Nutrition Examination Survey (KNHANES) database from 2007 to 2012, and linked the data of COPD patients who had mild to moderate airflow obstruction (n = 1,320) to National Health Insurance (NHI) data...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Lena Heinbockel, Sebastian Marwitz, Andra B Schromm, Henrik Watz, Christian Kugler, Ole Ammerpohl, Karoline Schnepf, Klaus F Rabe, Daniel Droemann, Torsten Goldmann
Introduction: As part of a study aimed at illuminating at least some of the complex molecular events taking place in COPD, we screened tissues by means of transcriptome analyses. Materials and methods: Tissues were subjected to transcriptome analysis. Candidate genes were identified and validated by immunohistochemistry. Primary human lung cells were subjected to stimulation with cigarette smoke extract for further validation by real time PCR. Results: Six candidate genes were selected for further investigations: Aquaporin 3 ( AQP3 ), extracellular matrix protein 1 ( ECM1 ), four and a half LIM domain 1 ( FHL1 ), milk fat globule epidermal growth factor 8 ( MFGE8 , lactadherin), phosphodiesterase 4D-interacting protein ( PDE4DIP ), and creatine transporter SLC6A8 ...
2018: International Journal of Chronic Obstructive Pulmonary Disease
(no author information available yet)
[This corrects the article on p. 695 in vol. 13, PMID: 29520137.].
2018: International Journal of Chronic Obstructive Pulmonary Disease
Julio Hernández Vázquez, Ismael Ali García, Rodrigo Jiménez-García, Alejandro Álvaro Meca, Ana López de Andrés, Carmen Matesanz Ruiz, María Jesús Buendía García, Javier de Miguel Díez
Background: The aim of the study was to analyze the characteristics and survival of a group of patients with COPD according to their clinical phenotype. Patients and methods: The study population was selected from patients undergoing scheduled spirometry between January 1, 2011 and June 30, 2011 at the respiratory function laboratory of a teaching hospital and comprised those with a previous and confirmed diagnosis of COPD and forced expiratory volume in the first second (FEV1 ) of <70%...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Eleonore H Koolen, Philip J van der Wees, Gert P Westert, Richard Dekhuijzen, Yvonne F Heijdra, Alex J van 't Hul
Background: Projections on the future suggest a further rise in the prevalence of patients with COPD, and in COPD related morbidity, mortality, and health care costs worldwide. Given the substantial impact on the individual and on society, it is important to establish a care process that maximizes outcomes in relation to the costs and efforts made. In an attempt to bridge this gap, we set out to develop an evidence-based model of integrated care for patients with COPD, named the COPDnet integrated care model...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Eleonore H Koolen, Philip J van der Wees, Gert P Westert, Richard Dekhuijzen, Yvonne F Heijdra, Alex J van 't Hul
Introduction: This research project sets out to design an integrated disease management model for patients with COPD who were referred to a secondary care setting and who qualified for pharmacological and nonpharmacological intervention options. Theory and methods: The integrated disease management model was designed according to the guidelines of the European Pathway Association and the content founded on the Chronic Care Model, principles of integrated disease management, and knowledge of quality management systems...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Konstantina Kontogianni, Kanoe Russell, Ralf Eberhardt, Maren Schuhmann, Claus Peter Heussel, Susan Wood, Felix Jf Herth, Daniela Gompelmann
Objectives: Bronchoscopic lung volume reduction using coils (LVRC) is a well-known treatment option for severe emphysema. The purpose of this study was to identify quantitative computed tomography (QCT) and clinical parameters associated with positive treatment outcome. Patients and methods: The CT scans, pulmonary function tests (PFT), and 6-minute walk test (6-MWT) data were collected from 72 patients with advanced emphysema prior to and at 3 months after LVRC treatment...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Arschang Valipour, Sherwin Asadi, Christophe Pison, Marie Jondot, Romain Kessler, Khaled Benneddif, Gaetan Deslee, Margaux Verdier, Dirk-Jan Slebos, Martin Mayse
Background: Targeted lung denervation (TLD) is a novel bronchoscopic therapy for COPD which ablates parasympathetic pulmonary nerves running along the outside of the two main bronchi with the intent of inducing permanent bronchodilation. The goal of this study was to evaluate the feasibility and long-term safety of bilateral TLD during a single procedure. Patients and methods: This prospective, multicenter study evaluated 15 patients with moderate-to-severe COPD (forced expiratory volume in 1 s [FEV1 ] 30%-60%) who underwent bilateral TLD treatment following baseline assessment without bronchodilators...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Seda Tural Onur, Samim Emet, Sinem Nedime Sokucu, Imran Onur
Introduction: The interval from the peak to the end of the electrocardiographic (ECG) T wave (Tp-Te) can estimate cardiovascular mortality and ventricular tachyarrhythmias. Objectives: In this study, we aimed to define a new ECG parameter in patients with COPD. Methods: This was a cross-sectional observational study that included COPD patients who were diagnosed previously and followed up in the outpatient clinic. All data of the patients' demographic features, history, spirometry, and electrocardiographs were analyzed...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Masakazu Ichinose, Masaharu Nishimura, Manabu Akimoto, Yasuhiro Kurotori, Yihua Zhao, Alberto de la Hoz, Michiaki Mishima
Background: The DYNAGITO study was a Phase IIIb, randomized, double-blind, multicenter, active-controlled, parallel-group, 52-week study designed to determine the efficacy and safety of tiotropium and olodaterol combination therapy (TIO+OLO 5/5 μg) versus tiotropium monotherapy (TIO 5 μg) for reducing moderate-to-severe exacerbations of COPD. This is a prespecified analysis of the DYNAGITO data in Japanese patients. Patients and methods: Enrolled patients had a diagnosis of COPD with at least one moderate-to-severe exacerbation in the previous 12 months...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jeong Uk Lim, Chang Dong Yeo, Chin Kook Rhee, Yong Hyun Kim, Chan Kwon Park, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Hyoung Kyu Yoon, Sang Haak Lee
Objectives: Focusing on the advanced non-small cell lung cancer (NSCLC) patients without driver mutations can elucidate the clinical impact of COPD on treatment outcomes. The present study evaluated the effects of COPD on the overall survival of driver mutation-negative NSCLC patients undergoing conventional chemotherapy as the first-line treatment. Patients and methods: Medical records of stage IIIB and IV NSCLC patients from January 2008 to December 2015 from six university hospitals were reviewed...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Liting Zhou, Ying Liu, Xin Chen, Shuyue Wang, Hongbo Liu, Tianrong Zhang, Yuezhu Zhang, Qi Xu, Xu Han, Yaming Zhao, Xinyue Song, Lin Ye
Background: Nuclear factor-κB (NF-κB) signaling plays essential roles in inflammatory responses. However, whether the expression levels of NF-κB family genes affect inflammatory responses is unclear. Moreover, little is known regarding the association between NF-κB family genes expression and the pathogenesis of chronic obstructive pulmonary disease (COPD). The present study was undertaken to assess the relationship between the expression levels of NF-κB family genes mRNA and of inflammatory markers relevant to COPD pathogenesis...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Srinivas Annavarapu, Seth Goldfarb, Melissa Gelb, Chad Moretz, Andrew Renda, Shuchita Kaila
Background: Patients with COPD often experience severe exacerbations involving hospitalization, which accelerate lung function decline and reduce quality of life. This study aimed to develop and validate a predictive model to identify patients at risk of developing severe COPD exacerbations using administrative claims data, to facilitate appropriate disease management programs. Methods: A predictive model was developed using a retrospective cohort of COPD patients aged 55-89 years identified between July 1, 2010 and June 30, 2013 using Humana's claims data...
2018: International Journal of Chronic Obstructive Pulmonary Disease
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