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Clinical Interventions in Aging

Yi Zhu, Han Wu, Ming Qi, Sheng Wang, Qin Zhang, Li Zhou, Shiyan Wang, Wei Wang, Ting Wu, Ming Xiao, Siyu Yang, Hong Chen, Ling Zhang, Kathryn Chu Zhang, Jinhui Ma, Tong Wang
Background: Mild cognitive impairment (MCI) is known as a transitional stage or phase between normal aging and dementia. In addition, it is associated with an increased risk of dementia. Research has shown that moderate-intensity exercise is associated with a decreased risk of cognitive impairment. Two recent studies demonstrated that dance interventions are associated with improved cognitive function in the elderly with MCI. Purpose: We evaluated the effect of a moderate-intensity aerobic dance routine on the cognitive function in patients with MCI...
2018: Clinical Interventions in Aging
Masahisa Arahata, Hidesaku Asakura
Compared with younger people, elderly people have higher risks for both thrombosis and bleeding. Furthermore, comorbidities frequently found in elderly patients complicate the management of antithrombotic therapy. Thus, when treating these patients, physicians often find it difficult to incorporate the principles of evidence-based medicine and must determine the best treatment option for each patient. Recently, in the fields of cerebrovascular and cardiovascular diseases, researchers have been rapidly accumulating new data regarding antithrombotic therapy, particularly in the areas of direct oral anticoagulants (DOACs) and dual antiplatelet therapy (DAPT)...
2018: Clinical Interventions in Aging
Zhen Wang, Ji Xiao, Zitao Zhang, Xusheng Qiu, Yixin Chen
Background: Preoperative deep vein thrombosis (DVT) is a common complication in patients with hip fractures. Chronic kidney disease (CKD) as a frequent comorbidity in middle-aged and elderly patients with hip fractures is known to promote a proinflammatory and prothrombotic state. We aimed to identify whether CKD can increase the risk of DVT in middle-aged and elderly patients with hip fractures, as well as identify other risk factors. Patients and methods: We retrospectively studied 248 middle-aged and elderly patients with hip fractures who were admitted to our hospital from January 2016 to June 2017, meeting all the inclusion criteria...
2018: Clinical Interventions in Aging
Gianfranco Piccirillo, Federica Moscucci, Fabiola Mastropietri, Claudia Di Iorio, Marco Valerio Mariani, Marcella Fabietti, Gaetana M Stricchiola, Ilaria Parrotta, Gennaro Sardella, Massimo Mancone, Damiano Magrì
Objectives: To evaluate the predicative power of the electrical risk score (ERS), a noninvasive and inexpensive test obtained by means of a standard 12-lead electrocardiogram (ECG), in a cohort of elderly patients who had undergone transcatheter aortic valve replacement (TAVR). Methods: Survivors and non-survivors after TAVR at 1-year follow-up were compared in respect to the pre-procedural ERS as well as a number of other clinical and instrumental variables. ERS is composed of seven simple ECG markers: heart rate (>75 bpm); QRS duration (>110 ms); left ventricular hypertrophy (Sokolow-Lyon criteria); delayed QRS transition zone (≥ V4); frontal QRS-T angle (>90°); long QTBazett (>450 ms for men and >460 in women) or JTBazett (330 ms for men and >340 ms for women); and long Tpeak to Tend interval (Tp-e ) (>89 ms)...
2018: Clinical Interventions in Aging
Tom M Quinn, Adam T Hill
Bronchiectasis is a chronic lung disease with permanently damaged airways predisposing to recurrent respiratory tract infections. There is an increasing prevalence of bronchiectasis in the elderly, affecting approximately 10 patients per 1,000 population. Studies have shown that older, frailer patients tend to have a more severe and symptomatic disease, with those aged 80 and above with worse quality of life, increased hospitalization and increased mortality. These patients will be encountered by clinicians working in all aspects of elderly care...
2018: Clinical Interventions in Aging
(no author information available yet)
[This corrects the article on p. 737 in vol. 13, PMID: 29731615.].
2018: Clinical Interventions in Aging
Wei-Jun Guo, Ji-Qi Wang, Wei-Jiang Zhang, Wei-Kang Wang, Ding Xu, Peng Luo
Purpose: Several authors have reported the degree of total blood loss (TBL) following hemiarthroplasty for displaced femoral neck fracture; however, the research specifically investigating on hidden blood loss (HBL) after hip hemiarthroplasty is still lacking. The purpose of this study is to evaluate the HBL in patients who underwent hip hemiarthroplasty for displaced femoral neck fractures and to analyze its risk factors. Patients and methods: From January 2015 to December 2016, 212 patients (57 males and 155 females) with displaced femoral neck fracture undergoing hip hemiarthroplasty were included in this study...
2018: Clinical Interventions in Aging
Daisuke Kudo, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Yoshinori Ishikawa, Masashi Fujii, Yoichi Shimada
Background: Kyphosis is a spine deformity that can lead to falls and reduced quality of life. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) regulates mitochondrial biogenesis and is important for proper functioning of skeletal muscle, including the paraspinal muscles, which support and allow movement of the spine. The role of PGC-1α in paraspinal muscles in lumbar kyphosis has not been examined. We also examined the expressions of the proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6...
2018: Clinical Interventions in Aging
(no author information available yet)
[This corrects the article on p. 1237 in vol. 13, PMID: 30034227.].
2018: Clinical Interventions in Aging
Saad Abdulrahman Hussain, Bushra Hassan Marouf, Ziyad Serdar Ali, Runj Simko Ahmmad
Background and aim: Resveratrol shows remarkable anti-inflammatory activities in experimental models. This study aims to evaluate the effect of resveratrol, as an adjuvant with meloxicam (Mlx), on the pain and functional activity during a 90-day period and monitor the adverse effects on kidney and liver functions, lipid profile, and hematological markers. Patients and methods: This study was a double-blind, placebo-controlled, randomized multi-center study that involved 110 patients with knee osteoarthritis (OA) and was performed at Sulaimani City, Iraq, from December 2016 to September 2017...
2018: Clinical Interventions in Aging
Rocío Fernández-Ballesteros, Macarena Sánchez-Izquierdo, Ricardo Olmos, Carmen Huici, Marta Santacreu, Rocío Schettini, María Ángeles Molina
Introduction: The main goal of the present study was to examine the stereotype content model (SCM) assumption for universality and to test whether the mediating role of cultural views about older adult caregivers is maintained in other health care contexts. Methods: One hundred and sixty professionals and volunteers who worked with older adults in day care centers (DCCs) and senior citizen centers (SCCs) and 1,151 participants from a representative sample of the Spanish population were examined using the SCM questionnaire; older adult and personnel functioning were assessed through an observation procedure with two subscales of the Evaluation Scale from the Sistema de Evaluación de Residencias de Ancianos...
2018: Clinical Interventions in Aging
Hui Wang, Shan Hai, Yixin Liu, Li Cao, Ying Liu, Ping Liu, Jianghua Zhou, Ying Yang, Birong Dong
Purpose: The aim of this study was to assess the prevalence of sarcopenia and depressive symptoms and estimate the association between them in elderly Chinese community-dwelling individuals. Patients and methods: A total of 948 elderly Chinese community-dwelling individuals were recruited through leaflets and posters from three communities in Chengdu, and 865 participants were analyzed in this cross-sectional study. Muscle mass was measured using the bioimpedance analysis, handgrip strength was measured with a handheld dynamometer, and physical performance was assessed via usual gait speed on a 6 m course...
2018: Clinical Interventions in Aging
Zhen Du, Yuewei Li, Jinwei Li, Changli Zhou, Feng Li, Xige Yang
Background/objective: Alzheimer's disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD. Methods: The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018...
2018: Clinical Interventions in Aging
Pei Zhang, Jianzhong Bai, Jinshan He, Yuan Liang, Pengtao Chen, Jingcheng Wang
Background: Patients undergoing femoral fracture surgery frequently require blood transfusion. Tranexamic acid (TXA) has been widely used to decrease transfusion rate in joint replacement surgery. Therefore, we conducted a systematic review to evaluate the efficacy and safety of TXA usage in femoral fracture surgery. Materials and methods: Studies involving TXA usage in femoral fracture surgery were searched through four electronic databases. The end points included total blood loss, postoperative hemoglobin decline, transfusion rate, thromboembolic events, 90-day mortality, and operative time...
2018: Clinical Interventions in Aging
Cay Anderson-Hanley, Jessica Stark, Kathryn M Wall, Marisa VanBrakle, Makenzie Michel, Molly Maloney, Nicole Barcelos, Kristina Striegnitz, Brian D Cohen, Arthur F Kramer
Background: Alzheimer's and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI). Aim: This pilot clinical trial ( Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise. Participants and methods: Older adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACES™]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory Lane™)...
2018: Clinical Interventions in Aging
Maria Parvaneh, Golgis Karimi, Rosita Jamaluddin, Min Hwei Ng, Ibrahim Zuriati, Sani Ismaila Muhammad
Purpose: Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of Lactobacillus helveticus ( L. helveticus ) on bone health status among ovariectomized (OVX) bone loss-induced rats. Methods: The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+ L...
2018: Clinical Interventions in Aging
Leila Djabelkhir-Jemmi, Ya-Huei Wu, Marouane Boubaya, Fabienne Marlats, Manon Lewis, Jean-Sébastien Vidal, Hermine Lenoir, Benoit Charlieux, Baptiste Isabet, Anne-Sophie Rigaud
Objective: This study aimed to explore whether a computerized cognitive stimulation program (CCS) induced differential effects in older adults with mild cognitive impairment (MCI) according to the severity of white matter hyperintensities (WMH), which are associated with cognitive impairment and increased risk of progression to Alzheimer's disease because of the damage they cause to cortical and subcortical networks. Patients and methods: Twenty-nine MCI patients with no or little WMH (MCI-non-WMH) and 22 MCI patients with moderate or severe WMH (MCI-WMH) attended a 24-session CCS program (two sessions per week for a duration of 3 months) focused on executive functions, attention, and processing speed...
2018: Clinical Interventions in Aging
John Chapin
Von Willebrand disease (VWD) is an inherited bleeding disorder that affects up to 1% of the population. In most cases, VWD results from a mutation in the von Willebrand Factor (VWF) gene, which alters the amount and function of VWF, a key glycoprotein in both primary and secondary hemostasis. A comprehensive analysis of patients with VWD should include VWF activity, antigen levels, platelet function, and a careful bleeding history. Treatment options include antifibrinolytics, desmopressin, and VWF replacement therapy...
2018: Clinical Interventions in Aging
Qian Tong, Wanzhen Wu, Qing Wu, Yanbo Yu, Xiaoling Lv, Bozhong Wang, Guofu Wang
Purpose: Inconsistent outcome about association between insufficient sleep and bone mineral density (BMD) has been reported. The present study aimed to determine whether BMD was associated with score of Pittsburgh Sleep Quality Index (PSQI). Methods: A total of 410 patients (mean age 81.6±5.9 years) attending our hospital for evaluation of sleep were retrospectively studied. Dual-Energy X-ray Absorptiometry was used to measure BMD and T-score at femoral neck and lumbar spines over L2-L4 regions...
2018: Clinical Interventions in Aging
Chunyan Guan, Huiyan Niu
The number of patients with chronic obstructive pulmonary disease (COPD) has been rising with continued exposure to environmental risk factors and aging of populations around the world. Frailty is a geriatric syndrome with a decline in physiological reserve and often coexists with chronic diseases such as COPD. Frailty is an independent risk factor for the development and progression of COPD, and COPD can lead to frailty; treating one might improve the other. Thus, there is an increasing interest in the assessment of frailty in patients with COPD...
2018: Clinical Interventions in Aging
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