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Clinical Interventions in Aging

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https://www.readbyqxmd.com/read/28603411/effect-of-small-dose-levosimendan-on-mortality-rates-and-organ-functions-in-chinese-elderly-patients-with-sepsis
#1
Xin Wang, Shikui Li
AIM: As a primary cause of death not only in Western countries but also in the People's Republic of China, sepsis is diagnosed as abnormal organ functions as a result of a disordered response to a severe infection. This study was designed to assess the effect of small-dose levosimendan without a loading dose on mortality rates and organ functions in Chinese elderly patients with sepsis. METHODS: Following a prospective, randomized, and double-blinded design, 240 Chinese elderly patients with sepsis shock were admitted to the intensive care unit (ICU)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28603410/full-thickness-macular-hole-formation-following-anti-vegf-injections-for-neovascular-age-related-macular-degeneration
#2
Stamatina A Kabanarou, Tina Xirou, George Mangouritsas, Christina Garnavou-Xirou, Eirini Boutouri, Ilias Gkizis, Irini Chatziralli
PURPOSE: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment. METHODS: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28603409/association-between-butyrylcholinesterase-k-variant-and-mild-cognitive-impairment-in-the-thai-community-dwelling-patients
#3
Natsalil Pongthanaracht, Somchai Yanarojana, Darawan Pinthong, Supeenun Unchern, Amnuay Thithapandha, Prasert Assantachai, Porntip Supavilai
OBJECTIVE: To study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients. METHODS: One hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman's method...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28579767/cognitive-decline-in-normal-aging-and-its-prevention-a-review-on-non-pharmacological-lifestyle-strategies
#4
REVIEW
Blanka Klimova, Martin Valis, Kamil Kuca
The purpose of this study is to examine the effects of the selected non-pharmacological lifestyle activities on the delay of cognitive decline in normal aging. This was done by conducting a literature review in the four acknowledged databases Web of Science, Scopus, MEDLINE, and Springer, and consequently by evaluating the findings of the relevant studies. The findings show that physical activities, such as walking and aerobic exercises, music therapy, adherence to Mediterranean diet, or solving crosswords, seem to be very promising lifestyle intervention tools...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28579766/effects-of-multi-domain-interventions-in-pre-frail-elderly-on-frailty-functional-and-cognitive-status-a-systematic-review
#5
REVIEW
Lenore Dedeyne, Mieke Deschodt, Sabine Verschueren, Jos Tournoy, Evelien Gielen
BACKGROUND: Frailty is an aging syndrome caused by exceeding a threshold of decline across multiple organ systems leading to a decreased resistance to stressors. Treatment for frailty focuses on multi-domain interventions to target multiple affected functions in order to decrease the adverse outcomes of frailty. No systematic reviews on the effectiveness of multi-domain interventions exist in a well-defined frail population. OBJECTIVES: This systematic review aimed to determine the effect of multi-domain compared to mono-domain interventions on frailty status and score, cognition, muscle mass, strength and power, functional and social outcomes in (pre)frail elderly (≥65 years)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28579765/effects-of-a-giant-exercising-board-game-intervention-on-ambulatory-physical-activity-among-nursing-home-residents-a-preliminary-study
#6
Alexandre Mouton, Nicolas Gillet, Flore Mouton, Dave Van Kann, Olivier Bruyère, Marc Cloes, Fanny Buckinx
PURPOSE: This study examined the effects of a giant (4×3 m) exercising board game intervention on ambulatory physical activity (PA) and a broader array of physical and psychological outcomes among nursing home residents. MATERIALS AND METHODS: A quasi-experimental longitudinal study was carried out in two comparable nursing homes. Ten participants (aged 82.5±6.3 and comprising 6 women) meeting the inclusion criteria took part in the 1-month intervention in one nursing home, whereas 11 participants (aged 89...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553093/applications-of-direct-to-consumer-hearing-devices-for-adults-with-hearing-loss-a-review
#7
REVIEW
Vinaya Manchaiah, Brian Taylor, Ashley L Dockens, Nicole R Tran, Kayla Lane, Mariana Castle, Vibhu Grover
BACKGROUND: This systematic literature review is aimed at investigating applications of direct-to-consumer hearing devices for adults with hearing loss. This review discusses three categories of direct-to-consumer hearing devices: 1) personal sound amplification products (PSAPs), 2) direct-mail hearing aids, and 3) over-the-counter (OTC) hearing aids. METHOD: A literature review was conducted using EBSCOhost and included the databases CINAHL, MEDLINE, and PsycINFO...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553092/relationship-between-sarcopenia-and-physical-activity-in-older-people-a-systematic-review-and-meta-analysis
#8
REVIEW
Michal Steffl, Richard W Bohannon, Lenka Sontakova, James J Tufano, Kate Shiells, Iva Holmerova
Physical activity (PA) has been identified as beneficial for many diseases and health disorders, including sarcopenia. The positive influence of PA interventions on sarcopenia has been described previously on many occasions. Current reviews on the topic include studies with varied PA interventions for sarcopenia; nevertheless, no systematic review exploring the effects of PA in general on sarcopenia has been published. The main aim of this study was to explore the relationship between PA and sarcopenia in older people on the basis of cross-sectional and cohort studies...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553091/improving-the-diagnosis-and-treatment-of-osteoporosis-using-a-senior-friendly-peer-led-community-education-and-mentoring-model-a-randomized-controlled-trial
#9
Marita Kloseck, Deborah A Fitzsimmons, Mark Speechley, Marie Y Savundranayagam, Richard G Crilly
BACKGROUND: This randomized controlled trial (RCT) evaluated a 6-month peer-led community education and mentorship program to improve the diagnosis and management of osteoporosis. METHODS: Ten seniors (74-90 years of age) were trained to become peer educators and mentors and deliver the intervention. In the subsequent RCT, 105 seniors (mean age =80.5±6.9; 89% female) were randomly assigned to the peer-led education and mentorship program (n=53) or control group (n=52)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553090/anti-amyloid-aggregation-activity-of-novel-carotenoids-implications-for-alzheimer-s-drug-discovery
#10
Johant Lakey-Beitia, Deborah Doens, D Jagadeesh Kumar, Enrique Murillo, Patricia L Fernandez, K S Rao, Armando A Durant-Archibold
Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health. In this research, the anti-amyloidogenic activity of three carotenoids, cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin, was assessed...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553089/effect-of-frailty-syndrome-on-treatment-compliance-in-older-hypertensive-patients
#11
Anna Chudiak, Beata Jankowska-Polańska, Izabella Uchmanowicz
BACKGROUND: Frailty syndrome (FS) is an important problem in older persons. It may develop concomitantly to many aging-related diseases, including arterial hypertension, and exerts detrimental effects on both their outcomes and treatment compliance. OBJECTIVE: To analyze the effect of FS on treatment compliance in older hypertensive patients. MATERIALS AND METHODS: This study of 300 hypertensive patients (167 women and 133 men) aged between 65 and 91 years (mean 71...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553088/blood-pressure-reactivity-to-mental-stress-is-attenuated-following-resistance-exercise-in-older-hypertensive-women
#12
Rafael Gauche, Ricardo M Lima, Jonathan Myers, André B Gadelha, Silvia Gr Neri, Claudia Lm Forjaz, Lauro C Vianna
PURPOSE: This study aimed to investigate the effects of resistance exercise (RE) on autonomic control and blood pressure (BP) reactivity during mental stress (MS) in treated older hypertensive women. METHODS: Ten older hypertensive women (age =71.1±5.5 years; body mass index =24.2±3.9; mean BP [MBP] =85.4±3.5) underwent a protocol consisting of BP and heart rate variability (HRV) output assessments at baseline and during MS, and these measurements were taken before and 60 minutes after two bouts of RE (traditional and circuit)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28553087/association-of-dry-eye-disease-with-psychiatric-or-neurological-disorders-in-elderly-patients
#13
REVIEW
Sang Beom Han, Hee Kyung Yang, Joon Young Hyon, Won Ryang Wee
Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy. The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease. Recent studies have suggested the role of neurological or psychological factors in the development of dry eye symptoms and discrepancy of the symptoms and signs, particularly in elderly patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28546744/effect-of-exercise-on-cognitive-function-in-chronic-disease-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#14
REVIEW
Hong Cai, Guichen Li, Shanshan Hua, Yufei Liu, Li Chen
BACKGROUND: The purpose of this study was to conduct a meta-analysis and systematic review to assess the effect of exercise on cognitive function in people with chronic diseases. METHODS: PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, PsycINFO, and three Chinese databases were electronically searched for papers that were published until September 2016. This meta-analysis and systematic review included randomized controlled trials that evaluated the effect of exercise on cognitive function compared with control group for people with chronic diseases...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28546743/common-methods-of-biological-age-estimation
#15
REVIEW
Linpei Jia, Weiguang Zhang, Xiangmei Chen
At present, no single indicator could be used as a golden index to estimate aging process. The biological age (BA), which combines several important biomarkers with mathematical modeling, has been proposed for >50 years as an aging estimation method to replace chronological age (CA). The common methods used for BA estimation include the multiple linear regression (MLR), the principal component analysis (PCA), the Hochschild's method, and the Klemera and Doubal's method (KDM). The fundamental differences in these four methods are the roles of CA and the selection criteria of aging biomarkers...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28496313/relationships-of-pancreatic-beta-cell-function-with-microalbuminuria-and-glomerular-filtration-rate-in-middle-aged-and-elderly-population-without-type-2-diabetes-mellitus-a-chinese-community-based-analysis
#16
Shihui Fu, Shanjing Zhou, Leiming Luo, Ping Ye
BACKGROUND: Relationships of pancreatic beta-cell function abnormality with microalbuminuria (MA) and glomerular filtration rate (GFR) may differ by age, ethnicity and accompanied diseases. Previous studies were generally conducted in Western adult patients with type 2 diabetes mellitus (T2DM), and it is uncertain whether pancreatic beta-cell function is associated with MA and GFR in Chinese community-dwelling middle-aged and elderly population without T2DM. We therefore examined the relationships of pancreatic beta-cell function with two indices of renal damage, MA and GFR, in Chinese community-dwelling middle-aged and elderly population without T2DM...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28496312/body-mass-index-is-associated-with-type-2-diabetes-mellitus-in-chinese-elderly
#17
Qianping Zhao, Jari A Laukkanen, Qifu Li, Gang Li
BACKGROUND: There is limited information on the association between metabolic syndrome components including body mass index (BMI) and type 2 diabetes mellitus in elderly Chinese population. Therefore, we investigated whether components of metabolic syndrome are associated with type 2 diabetes mellitus in elderly. METHODS: A total of 479 hospitalized patients (aged 65-95 years) with recently diagnosed type 2 diabetes mellitus were studied retrospectively in a cross-sectional study and compared with 183 subjects with prediabetes and 62 subjects without glucose metabolism abnormalities...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28496311/letter-regarding-the-article-the-impact-of-hypomagnesemia-on-erectile-dysfunction-in-elderly-non-diabetic-stage-3-and-4-chronic-kidney-disease-patients-a-prospective-cross-sectional-study
#18
COMMENT
Pasquale Fatuzzo, Luca Zanoli, Viviana Scollo
No abstract text is available yet for this article.
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28490866/nonpharmacological-interventions-to-treat-physical-frailty-and-sarcopenia-in-older-patients-a-systematic-overview-the-senator-project-ontop-series
#19
REVIEW
Isabel Lozano-Montoya, Andrea Correa-Pérez, Iosief Abraha, Roy L Soiza, Antonio Cherubini, Denis O'Mahony, Alfonso J Cruz-Jentoft
BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them. OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28461745/depression-and-chronic-pain-in-the-elderly-links-and-management-challenges
#20
REVIEW
Panagiotis Zis, Argyro Daskalaki, Ilia Bountouni, Panagiota Sykioti, Giustino Varrassi, Antonella Paladini
Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links...
2017: Clinical Interventions in Aging
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