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Clinical Interventions in Aging

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https://www.readbyqxmd.com/read/28721032/-11-c-pib-pet-imaging-reveals-that-amyloid-deposition-in-cases-with-early-onset-alzheimer-s-disease-in-the-absence-of-known-mutations-retains-higher-levels-of-pib-in-the-basal-ganglia
#1
Young Chul Youn, Jae-Won Jang, Su-Hyun Han, HyeRyoun Kim, Ju-Won Seok, Jun Soo Byun, Kwang-Yeol Park, Seong Soo A An, In Kook Chun, SangYun Kim
PURPOSE: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. METHODS: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone (11)C-labeled Pittsburgh compound B-positron emission tomography imaging...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721031/operationalizing-a-frailty-index-using-routine-blood-and-urine-tests
#2
Martin Ritt, Jakob Jäger, Julia Isabel Ritt, Cornel Christian Sieber, Karl-Günter Gaßmann
BACKGROUND: Uncomplicated frailty instruments are desirable for use in a busy clinical setting. The aim of this study was to operationalize a frailty index (FI) from routine blood and urine tests, and to evaluate the properties of this FI compared to other frailty instruments. MATERIALS AND METHODS: We conducted a secondary analysis of a prospective cohort study on 306 patients aged ≥65 years hospitalized on geriatric wards. An FI comprising 22 routine blood parameters and one standard urine parameter (FI-Lab), a 50-item FI based on a comprehensive geriatric assessment (FI-CGA), a combined FI (FI-combined [items from the FI-Lab + others from the FI-CGA]), the Clinical Frailty Scale, rule-based frailty definition, and frailty phenotype were operationalized from data obtained during patients' hospital stays (ie, before discharge [baseline examination])...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721030/regular-physical-exercise-improves-cardiac-autonomic-and-muscle-vasodilatory-responses-to-isometric-exercise-in-healthy-elderly
#3
Adriana de Oliveira Sarmento, Amilton da Cruz Santos, Ivani Credidio Trombetta, Marciano Moacir Dantas, Ana Cristina Oliveira Marques, Leone Severino do Nascimento, Bruno Teixeira Barbosa, Marcelo Rodrigues Dos Santos, Maria do Amparo Andrade, Anna Myrna Jaguaribe-Lima, Maria do Socorro Brasileiro-Santos
The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721029/the-impact-of-transient-and-persistent-acute-kidney-injury-on-short-term-outcomes-in-very-elderly-patients
#4
Qinglin Li, Meng Zhao, Xiaodan Wang
OBJECTIVES: Acute kidney injury (AKI) is a common complication in elderly patients and is associated with poor outcomes. However, the effect of transient and persistent geriatric AKI on short-term mortality is unclear. We aimed to study the incidence, clinical characteristics, and prognostic impact of transient and persistent AKI in such patients. METHODS: We retrospectively enrolled very elderly patients (≥75 years) from the geriatric department of the Chinese PLA General Hospital between 2007 and 2015...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721028/frailty-in-community-dwelling-older-adults-association-with-adverse-outcomes
#5
Sergio Sánchez-García, Carmen García-Peña, Antoni Salvà, Rosalinda Sánchez-Arenas, Víctor Granados-García, Juan Cuadros-Moreno, Laura Bárbara Velázquez-Olmedo, Ángel Cárdenas-Bahena
BACKGROUND: The study of frailty is important to identify the additional needs of medical long-term care and prevent adverse outcomes in community dwelling older adults. This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults. METHODS: A cross-sectional study was carried out from April to September 2014. The population sample was 1,252 older adults (≥60 years) who were beneficiaries of the Mexican Institute of Social Security (IMSS) in Mexico City...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721027/frequency-of-frailty-and-its-association-with-cognitive-status-and-survival-in-older-chileans
#6
Cecilia Albala, Lydia Lera, Hugo Sanchez, Barbara Angel, Carlos Márquez, Patricia Arroyo, Patricio Fuentes
BACKGROUND: Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability. OBJECTIVE: To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans. METHODS: Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. At baseline, 2,098 (67% women) of 2,372 participants were identified as having the frailty phenotype: weak handgrip dynamometry, unintentional weight loss, fatigue/exhaustion, five chair-stands/slow walking speed and difficulty walking (low physical activity)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721026/a-community-virtual-ward-model-to-support-older-persons-with-complex-health-care-and-social-care-needs
#7
C Lewis, Z Moore, F Doyle, A Martin, D Patton, L E Nugent
BACKGROUND: Globally the older population is increasing rapidly. As a result there is an increase in frail older persons living within the community, with increased risks of a hospital admission and higher mortality and morbidity rates. Due to complexity of care, health care professionals face challenges in providing effective case management and avoiding unplanned admissions to hospital. A community virtual ward (CVW) model was developed to assist health care professionals to support older persons at home during periods of illness and/or functional decline...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28694691/assessment-of-renal-function-in-geriatric-palliative-care-patients-comparison-of-creatinine-based-estimation-equations
#8
Ewa Deskur-Smielecka, Aleksandra Kotlinska-Lemieszek, Jerzy Chudek, Katarzyna Wieczorowska-Tobis
BACKGROUND: Renal function impairment is common in geriatric palliative care patients. Accurate assessment of renal function is necessary for appropriate drug dosage. Several equations are used to estimate kidney function. AIMS: 1) To investigate the differences (Δ) in kidney function assessed with simplified Modifi-cation of Diet in Renal Disease (MDRD), Berlin Initiative Study (BIS1), and Cockcroft-Gault (C-G) formulas in geriatric palliative care patients, and 2) to assess factors that may influence these differences...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28694690/social-participation-and-perceived-depression-among-elderly-population-in-south-africa
#9
Gang Hao, Ghose Bishwajit, Shangfeng Tang, Changping Nie, Lu Ji, Rui Huang
There is a growing consensus regarding the influence of various psychosocial factors such as degree of social participation on health and disease outcomes, quality of life, and general well-being. Older individuals with diminished motor and physical functionality suffer a heightened risk of social exclusion and loneliness. Previous studies have demonstrated the association between social exclusion and loneliness with mental health among the older population. In the present study, we aimed to investigate whether or not difficulty in social participation has any relationship with perceived depression among older individuals in South Africa...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28670115/the-influence-of-the-serotonergic-system-on-the-personality-and-quality-of-life-of-postmenopausal-women
#10
Daria Schneider-Matyka, Anna Jurczak, Małgorzata Szkup, Agnieszka Samochowiec, Anna Grzywacz, Sylwia Wieder-Huszla, Elżbieta Grochans
The aim of this study was to establish the relationship between personality traits of postmenopausal women and the presence of the 44-bp VNTR polymorphism in the serotonin transporter (5-HTT) (SLC6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. The study's aim was also to determine the influence of personality traits on the quality of postmenopausal women's lives. The study involved 214 postmenopausal women from northwest Poland, with an average age of 56.8±4.08 years. It was performed using the Temperament and Character Inventory-Revised and the Short Form Health Survey...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28670114/resistance-training-for-activity-limitations-in-older-adults-with-skeletal-muscle-function-deficits-a-systematic-review
#11
REVIEW
Evan V Papa, Xiaoyang Dong, Mahdi Hassan
Human aging results in a variety of changes to skeletal muscle. Sarcopenia is the age-associated loss of muscle mass and is one of the main contributors to musculoskeletal impairments in the elderly. Previous research has demonstrated that resistance training can attenuate skeletal muscle function deficits in older adults, however few articles have focused on the effects of resistance training on functional mobility. The purpose of this systematic review was to 1) present the current state of literature regarding the effects of resistance training on functional mobility outcomes for older adults with skeletal muscle function deficits and 2) provide clinicians with practical guidelines that can be used with seniors during resistance training, or to encourage exercise...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28652717/elder-self-neglect-research-and-practice
#12
REVIEW
XinQi Dong
Elder self-neglect is a global public health and human rights issue that threatens older people's health and safety. It commonly refers to refusal or failure to provide oneself with care and protection in areas of food, water, clothing, hygiene, medication, living environments, and safety precautions. While prevalent, the status of self-neglecting individuals remains largely unclear, in particular within community-dwelling populations. By reviewing the epidemiology of elder self-neglect (definition, prevalence, risk factors, and consequences) to date, the present paper identifies key research gaps such as methodological inconsistency in case identification and measurement, and study designs that are inadequate to determine risk factors of self-neglect...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28652716/can-we-improve-pain-and-sleep-in-elderly-individuals-with-transcranial-direct-current-stimulation-results-from-a-randomized-controlled-pilot-study
#13
Marie-Philippe Harvey, Dominique Lorrain, Marylie Martel, Kayla Bergeron-Vezina, Francis Houde, Mario Séguin, Guillaume Léonard
BACKGROUND: The prevalence of chronic pain and sleep disturbances substantially increases with age. Pharmacotherapy remains the primary treatment option for these health issues. However, side effects and drug interactions are difficult to control in elderly individuals. AIMS: The objective of this study was to assess the feasibility of conducting a randomized sham-controlled trial and to collect preliminary data on the efficacy of transcranial direct current stimulation (tDCS) to reduce pain and improve sleep in older adults suffering from chronic pain...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28652715/association-of-arteriosclerosis-and-or-atherosclerosis-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#14
Ximin Fan, Mengyun Zhu, Chen Chi, Shikai Yu, Jing Xiong, Yuyan Lu, Bin Bai, Yawei Xu, Yi Zhang
OBJECTIVE: Vascular abnormality includes two forms, arteriosclerosis (ARS) and atherosclerosis (ATS), which coexist in patients with cardiovascular (CV) diseases. However, whether their combination may lead to a worsening status in those patients remains unclear. We therefore aimed to investigate the association of ARS and/or ATS with hypertensive target organ damage (TOD). METHODS: From June 2014 to August 2015, a total of 1,599 community-dwelling elderly subjects (aged >65 years) from northern Shanghai were recruited...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28652714/the-safety-issues-and-hardware-related-complications-of-deep-brain-stimulation-therapy-a-single-center-retrospective-analysis-of-478-patients-with-parkinson-s-disease
#15
Jing Zhang, Tao Wang, Chen-Cheng Zhang, Kristina Zeljic, Shikun Zhan, Bo-Min Sun, Dian-You Li
INTRODUCTION: Deep brain stimulation (DBS) is a well-established therapy for the treatment of advanced Parkinson's disease (PD) in patients experiencing motor fluctuations and medication-refractory tremor. Despite the relative tolerability and safety of this procedure, associated complications and unnatural deaths are still unavoidable. METHODS: In this study, hardware-related complications and the causes of unnatural death were retrospectively analyzed in 478 patients with PD who were treated with DBS...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28603411/effect-of-small-dose-levosimendan-on-mortality-rates-and-organ-functions-in-chinese-elderly-patients-with-sepsis
#16
Xin Wang, Shikui Li
AIM: As a primary cause of death not only in Western countries but also in the People's Republic of China, sepsis is diagnosed as abnormal organ functions as a result of a disordered response to a severe infection. This study was designed to assess the effect of small-dose levosimendan without a loading dose on mortality rates and organ functions in Chinese elderly patients with sepsis. METHODS: Following a prospective, randomized, and double-blinded design, 240 Chinese elderly patients with sepsis shock were admitted to the intensive care unit (ICU)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28603410/full-thickness-macular-hole-formation-following-anti-vegf-injections-for-neovascular-age-related-macular-degeneration
#17
Stamatina A Kabanarou, Tina Xirou, George Mangouritsas, Christina Garnavou-Xirou, Eirini Boutouri, Ilias Gkizis, Irini Chatziralli
PURPOSE: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment. METHODS: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28603409/association-between-butyrylcholinesterase-k-variant-and-mild-cognitive-impairment-in-the-thai-community-dwelling-patients
#18
Natsalil Pongthanaracht, Somchai Yanarojana, Darawan Pinthong, Supeenun Unchern, Amnuay Thithapandha, Prasert Assantachai, Porntip Supavilai
OBJECTIVE: To study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients. METHODS: One hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman's method...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28579767/cognitive-decline-in-normal-aging-and-its-prevention-a-review-on-non-pharmacological-lifestyle-strategies
#19
REVIEW
Blanka Klimova, Martin Valis, Kamil Kuca
The purpose of this study is to examine the effects of the selected non-pharmacological lifestyle activities on the delay of cognitive decline in normal aging. This was done by conducting a literature review in the four acknowledged databases Web of Science, Scopus, MEDLINE, and Springer, and consequently by evaluating the findings of the relevant studies. The findings show that physical activities, such as walking and aerobic exercises, music therapy, adherence to Mediterranean diet, or solving crosswords, seem to be very promising lifestyle intervention tools...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28579766/effects-of-multi-domain-interventions-in-pre-frail-elderly-on-frailty-functional-and-cognitive-status-a-systematic-review
#20
REVIEW
Lenore Dedeyne, Mieke Deschodt, Sabine Verschueren, Jos Tournoy, Evelien Gielen
BACKGROUND: Frailty is an aging syndrome caused by exceeding a threshold of decline across multiple organ systems leading to a decreased resistance to stressors. Treatment for frailty focuses on multi-domain interventions to target multiple affected functions in order to decrease the adverse outcomes of frailty. No systematic reviews on the effectiveness of multi-domain interventions exist in a well-defined frail population. OBJECTIVES: This systematic review aimed to determine the effect of multi-domain compared to mono-domain interventions on frailty status and score, cognition, muscle mass, strength and power, functional and social outcomes in (pre)frail elderly (≥65 years)...
2017: Clinical Interventions in Aging
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