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Clinical Interventions in Aging

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https://www.readbyqxmd.com/read/28919727/five-year-durability-of-stand-alone-interspinous-process-decompression-for-lumbar-spinal-stenosis
#1
Pierce D Nunley, Vikas V Patel, Douglas G Orndorff, William F Lavelle, Jon E Block, Fred H Geisler
BACKGROUND: Lumbar spinal stenosis is the most common indication for spine surgery in older adults. Interspinous process decompression (IPD) using a stand-alone spacer that functions as an extension blocker offers a minimally invasive treatment option for intermittent neurogenic claudication associated with spinal stenosis. METHODS: This study evaluated the 5-year clinical outcomes for IPD (Superion(®)) from a randomized controlled US Food and Drug Administration (FDA) noninferiority trial...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919726/gene-expression-levels-of-the-insulin-like-growth-factor-family-in-patients-with-amd-before-and-after-ranibizumab-intravitreal-injections
#2
Barbara Strzalka-Mrozik, Malgorzata Kimsa-Furdzik, Adam Kabiesz, Katarzyna Michalska-Malecka, Malgorzata Nita, Urszula Mazurek
PURPOSE: The present study focused on the assessment of the mRNA levels of the insulin-like growth factor (IGF) family in patients with the exudative form of age-related macular degeneration (AMD) before and after ranibizumab intravitreal injections. PATIENTS AND METHODS: An analysis of the expression profile of the IGF family of genes in patients with AMD was carried out using the oligonucleotide microarray and quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) methods...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919725/correlations-between-satisfaction-with-life-and-selected-personal-resources-among-students-of-universities-of-the-third-age
#3
Halina Zielińska-Więczkowska
PURPOSE: The aim of the study was to identify personal resources, including health-related resources, sense of self-efficacy, attitude to life (optimism/pessimism) and self-assessment, and to determine their relationship with satisfaction with life in members of the Universities of the Third Age (U3As) in Poland. The impact of sociodemographic factors was analyzed. MATERIALS AND METHODS: The study included 320 participants of U3As; their mean age was 67.5 years and the vast majority of them were women (92...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919724/development-of-a-core-outcome-set-for-medication-review-in-older-patients-with-multimorbidity-and-polypharmacy-a-study-protocol
#4
Jean-Baptiste Beuscart, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Wilma Knol, Shane Cullinan, Claudio Schneider, Denis O'Mahony, Nicolas Rodondi, Anne Spinewine
BACKGROUND: Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28894359/analysis-of-the-dynamics-of-venous-blood-flow-in-the-context-of-lower-limb-temperature-distribution-and-tissue-composition-in-the-elderly
#5
Aleksandra Skomudek, Iwona Gilowska, Ryszard Jasiński, Krystyna Rożek-Piechura
OBJECTIVE: The elderly are particularly vulnerable to degenerative diseases, such as circulatory and respiratory system and vascular system diseases. The objective of this study was therefore to evaluate the distribution of temperature and the dynamics of venous blood flow in the lower limbs (LLs) and to assess the interdependence of these parameters in terms of the somatic components in males and females participating in activities at the University of the Third Age. MATERIALS AND METHODS: The study included 60 females (mean age 67...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28883717/assessing-balance-through-the-use-of-a-low-cost-head-mounted-display-in-older-adults-a-pilot-study
#6
Santiago J Saldana, Anthony P Marsh, W Jack Rejeski, Jack K Haberl, Peggy Wu, Scott Rosenthal, Edward H Ip
INTRODUCTION: As the population ages, the prevention of falls is an increasingly important public health problem. Balance assessment forms an important component of fall-prevention programs for older adults. The recent development of cost-effective and highly responsive virtual reality (VR) systems means new methods of balance assessment are feasible in a clinical setting. This proof-of-concept study made use of the submillimeter tracking built into modern VR head-mounted displays (VRHMDs) to assess balance through the use of visual-vestibular conflict...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28883716/spontaneous-cervical-artery-dissection-in-patients-aged-over-70-years-two-cases-and-systematic-literature-review
#7
Nolwenn Riou-Comte, Gioia Mione, Lisa Humbertjean, Marie-Alexia Ottenin, Jean-Christophe Lacour, Sébastien Richard
OBJECTIVE: Spontaneous cervical artery dissection (CAD) is a cerebrovascular disease typically considered to affect the young population. Literature reports cases in the elderly only as incidental findings, making the diagnosis unlikely in older patients. Incidence and pathogeny in this specific population remain to be assessed. METHODS: We reviewed patients aged over 70 years admitted for spontaneous CAD in the Stroke Unit of the University Hospital of Nancy (northeastern France) over a period of 12 years as well as all reported cases in literature...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28883715/impact-of-age-on-extracorporeal-membrane-oxygenation-survival-of-patients-with-cardiac-failure
#8
Su Nam Lee, Min Seop Jo, Ki-Dong Yoo
PURPOSE: Extracorporeal membrane oxygenation (ECMO) is used to treat patients in critical condition with cardiogenic shock. However, few studies have examined the effect of old age in ECMO survival. This study analyzed the impact of age on ECMO survival of patients with cardiac failure, and analyzed predictive factors for survival according to age. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 95 patients who required veno-arterial (V-A) ECMO between May 2009 and May 2016 at a single center...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28883714/vascular-aging-and-subclinical-atherosclerosis-why-such-a-never-ending-and-challenging-story-in-cardiology
#9
EDITORIAL
Stela Iurciuc, Anca Maria Cimpean, Florin Mitu, Rodica Heredea, Mircea Iurciuc
The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: "A man is as old as his arteries." Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860734/sex-differences-in-the-effect-of-aging-on-dry-eye-disease
#10
Jong Ho Ahn, Yoon-Hyeong Choi, Hae Jung Paik, Mee Kum Kim, Won Ryang Wee, Dong Hyun Kim
PURPOSE: Aging is a major risk factor in dry eye disease (DED), and understanding sexual differences is very important in biomedical research. However, there is little information about sex differences in the effect of aging on DED. We investigated sex differences in the effect of aging and other risk factors for DED. METHODS: This study included data of 16,824 adults from the Korea National Health and Nutrition Examination Survey (2010-2012), which is a population-based cross-sectional survey...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860733/recent-developments-in-age-related-macular-degeneration-a-review
#11
REVIEW
Waseem M Al-Zamil, Sanaa A Yassin
BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860732/should-physicians-always-rely-on-estimated-glomerular-filtration-rate-without-knowing-the-equation
#12
COMMENT
Fabio Fabbian, Dario Priori, Alfredo De Giorgi
No abstract text is available yet for this article.
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860731/egfrs-from-asian-modified-ckd-epi-and-chinese-modified-ckd-epi-equations-were-associated-better-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#13
Hongwei Ji, Han Zhang, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860730/association-between-body-composition-and-stair-negotiation-ability-among-individuals-55-years-of-age-a-cross-sectional-study
#14
Renata Maciulis Dip, Marcos As Cabrera, Sabrina Ferrari Prato
BACKGROUND: Loss of muscle strength exerts a considerable impact on the quality of life and mortality of older adults. The present household survey study measured body composition and muscle strength with the aim of analyzing the roles of low lean mass, low muscle strength and obesity in stair negotiation ability and the effect of comorbidities on the relationship between body composition and functional capacity. METHODS: Body composition was assessed using bioelectrical impedance analysis and muscle strength was assessed with a hand grip dynamometer...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860729/aging-and-extrapulmonary-effects-of-chronic-obstructive-pulmonary-disease
#15
Emanuela Tudorache, Ariadna Petronela Fildan, Mirela Frandes, Elena Dantes, Doina Ecaterina Tofolean
INTRODUCTION: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. AIM: The aim of this study is to compare functional performance and cognitive status in patients with COPD of different ages and to examine the changes in extrapulmonary effects...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28848334/predictors-of-high-on-aspirin-platelet-reactivity-in-elderly-patients-with-coronary-artery-disease
#16
J W Zhang, W W Liu, Timothy A McCaffrey, X Q He, W Y Liang, X H Chen, X R Feng, Sidney W Fu, M L Liu
OBJECTIVES: Previous studies have illustrated the link between high on-aspirin platelet reactivity (HAPR) with increasing thrombotic risks. The aim of our study was to investigate relative risk factors of HAPR in elderly patients with coronary artery disease. METHODS: Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016. Medical records of each patient were collected, including demographic information, cardiovascular risk factors, concomitant drugs and routine biological parameters...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28848333/mri-assessment-of-whole-brain-structural-changes-in-aging
#17
Hui Guo, William Siu, Ryan Cn D'Arcy, Sandra E Black, Lukas A Grajauskas, Sonia Singh, Yunting Zhang, Kenneth Rockwood, Xiaowei Song
PURPOSE: One of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. To collectively assess whole-brain structural changes, the MRI-based Brain Atrophy and Lesion Index (BALI) has been developed...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28848332/acute-care-of-severely-frail-elderly-patients-in-a-cga-unit-is-associated-with-less-functional-decline-than-conventional-acute-care
#18
Niklas Ekerstad, Synneve Dahlin Ivanoff, Sten Landahl, Göran Östberg, Maria Johansson, David Andersson, Magnus Husberg, Jenny Alwin, Björn W Karlson
BACKGROUND: A high percentage of individuals treated in specialized acute care wards are frail and elderly. Our aim was to study whether the acute care of such patients in a comprehensive geriatric assessment (CGA) unit is superior to care in a conventional acute medical care unit when it comes to activities of daily living (ADLs), frailty, and use of municipal help services. PATIENTS AND METHODS: A clinical, prospective, controlled trial with two parallel groups was conducted in a large county hospital in West Sweden and included 408 frail elderly patients, age 75 or older (mean age 85...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28848331/r2-gfr-chads2-and-r2-gfr-cha2ds2vasc-schemes-improved-the-performance-of-chads2-and-cha2ds2vasc-scores-in-death-risk-stratification-of-chinese-older-patients-with-atrial-fibrillation
#19
Shihui Fu, Shanjing Zhou, Leiming Luo, Ping Ye
BACKGROUND: This analysis was carried out to refine the CHADS2 and CHA2DS2VASc scores by combining creatinine clearance (CrCl) and glomerular filtration rate (GFR) and evaluate the performance of CrCl-based and GFR-based schemes in death risk stratification of Chinese older patients with atrial fibrillation (AF). METHODS: There were 219 older patients with AF, and all-cause mortality was assessed during the follow-up of 1.11 years. Renal function was evaluated using the CrCl formula and different GFR (Modification of Diet in Renal Disease [MDRD], Chinese MDRD [CMDRD], Mayo Clinic Quadratic [Mayo] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) formulas, and five kinds of R2CHADS2 and R2CHA2DS2VASc schemes were generated by combining CrCl and GFR with CHADS2 and CHA2DS2VASc scores...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28848330/yogurt-supplemented-with-probiotics-can-protect-the-healthy-elderly-from-respiratory-infections-a-randomized-controlled-open-label-trial
#20
Fangfang Pu, Yue Guo, Ming Li, Hong Zhu, Shijie Wang, Xi Shen, Miao He, Chengyu Huang, Fang He
PURPOSE: To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using a randomized, blank-controlled, parallel-group design. PATIENTS AND METHODS: Two hundred and five volunteers aged ≥45 years were randomly divided into two groups. The subjects in the intervention group were orally administered 300 mL/d of yogurt supplemented with a probiotic strain, Lactobacillus paracasei N1115 (N1115), 3...
2017: Clinical Interventions in Aging
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