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Clinical Interventions in Aging

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https://www.readbyqxmd.com/read/29317809/best-strategies-to-recruit-and-enroll-elderly-blacks-into-clinical-and-biomedical-research
#1
Lennox A Graham, Julius Ngwa, Oyonumo Ntekim, Oludolapo Ogunlana, Saba Wolday, Steven Johnson, Megan Johnson, Chimene Castor, Thomas V Fungwe, Thomas O Obisesan
Background: Historically, Blacks have been disproportionately underrepresented in clinical trials. Outcomes associated with low Blacks' participation in research include poor understanding of the predictors and treatment of the disease, increasing health disparities, poor health equity, and suboptimal wellness of the nation as a whole. To address this gap in research participation, we analyzed our recruitment data to identify the most effective strategies for enrolling older Blacks in clinical trials...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317808/clinical-utility-of-the-revised-cardiac-risk-index-in-older-chinese-patients-with-known-coronary-artery-disease
#2
Lu Che, Li Xu, Yuguang Huang, Chunhua Yu
Objectives: The revised Cardiac Risk Index (RCRI) is the most widely used risk prediction tool for postoperative cardiac adverse events. We aim to explore the predictive ability of the RCRI in older Chinese patients with coronary artery disease (CAD) undergoing noncardiac surgery, which has not been previously evaluated. Methods: We performed a multicenter, prospective study. We enrolled a total of 1,202 patients, aged >60 years, with a history of CAD who underwent noncardiac surgery...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317807/pain-assessment-in-impaired-cognition-paic-content-validity-of-the-dutch-version-of-a-new-and-universal-tool-to-measure-pain-in-dementia
#3
Annelore H van Dalen-Kok, Wilco P Achterberg, Wieke E Rijkmans, Sara A Tukker-van Vuuren, Suzanne Delwel, Henrica Cw de Vet, Frank Lobbezoo, Margot Wm de Waal
Objectives: Detection and measurement of pain in persons with dementia by using observational pain measurement tools is essential. However, the evidence for the psychometric properties of existing observational tools remains limited. Therefore, a new meta-tool has been developed: Pain Assessment in Impaired Cognition (PAIC), as a collaborative EU action. The aim is to describe the translation procedure and content validity of the Dutch version of the PAIC. Methods: Translation of the PAIC into Dutch followed the forward-backward approach of the Guidelines for Establishing Cultural Equivalence of Instruments...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317806/profile-of-sugammadex-for-reversal-of-neuromuscular-blockade-in-the-elderly-current-perspectives
#4
REVIEW
Michele Carron, Francesco Bertoncello, Giovanna Ieppariello
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of perioperative morbidity and mortality. Complications related to postoperative residual neuromuscular blockade, such as muscle weakness, airway obstruction, hypoxemia, atelectasis, pneumonia, and acute respiratory failure, are more frequent in older than in younger patients...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317805/compression-of-the-right-coronary-artery-by-an-aortic-pseudoaneurysm-after-infective-endocarditis-an-unusual-case-of-myocardial-ischemia
#5
Juan Lacalzada-Almeida, Alejandro De la Rosa-Hernández, María Manuela Izquierdo-Gómez, Javier García-Niebla, Iván Hernández-Betancor, Juan Alfonso Bonilla-Arjona, Antonio Barragán-Acea, Ignacio Laynez-Cerdeña
A 61-year-old male with a prosthetic St Jude aortic valve size 24 presented with heart failure symptoms and minimal-effort angina. Eleven months earlier, the patient had undergone cardiac surgery because of an aortic root dilatation and bicuspid aortic valve with severe regurgitation secondary to infectious endocarditis by Coxiela burnetii and coronary artery disease in the left circumflex coronary artery. Then, a prosthesis valve and a saphenous bypass graft to the left circumflex coronary artery were placed...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29317804/hip-muscle-and-hand-grip-strength-to-differentiate-between-older-fallers-and-non-fallers-a-cross-sectional-validity-study
#6
Simone C Gafner, Caroline H Bastiaenen, Serge Ferrari, Gabriel Gold, Philippe Terrier, Roger Hilfiker, Lara Allet
Background: Hip muscle weakness in older people seems to be an influencing factor of falls. Currently, it is unclear which muscles out of the hip muscle group play an important role in older people. A validating process in the measurement regarding muscle strength related to falls is necessary before answering that question. Objective: Firstly, we aimed to investigate which hip muscle group strength shows an acceptable level of distinction between older adult fallers and non-fallers compared to a predefined external criterion regarding falling...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29290683/erratum-drug-prescription-appropriateness-in-the-elderly-an-italian-study-corrigendum
#7
(no author information available yet)
[This corrects the article on p. 325 in vol. 12, PMID: 28228653.].
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29276381/a-new-data-analysis-approach-for-measuring-longitudinal-changes-of-metabolism-in-cognitively-normal-elderly-adults
#8
Sepideh Shokouhi, William R Riddle, Hakmook Kang
Introduction: Previously, we discussed several critical barriers in including [18F] fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging of preclinical Alzheimer's disease (AD) subjects. These factors included the reference region selection and intensity normalization of PET images and the within- and across-subject variability of affected brain regions. In this study, we utilized a novel FDG-PET analysis, the regional FDG time correlation coefficient, rFTC, that can address and resolve these barriers and provide a more sensitive way of monitoring longitudinal changes in metabolism of cognitively normal elderly adults...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29276380/a-multicenter-controlled-study-for-dementia-prevention-through-physical-cognitive-and-social-activities-gestalt-kompakt
#9
Anna Streber, Karim Abu-Omar, Christian Hentschke, Alfred Rütten
Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebenslange Tätigkeiten - kompakt [walking, playing and dancing as lifelong activities-compact] (GESTALT-kompakt) - would lead to significantly larger improvements in PA levels (step counts/Fitbit Zip™), cognitive functions (DemTect) and social activities (Social Activity Log), compared to an active control group...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29276379/average-annual-cost-of-parkinson-s-disease-in-s%C3%A3-o-paulo-brazil-with-a-focus-on-disease-related-motor-symptoms
#10
Tânia M Bovolenta, Sônia Maria Cesar de Azevedo Silva, Roberta Arb Saba, Vanderci Borges, Henrique Ballalai Ferraz, Andre C Felicio
Background: Although Parkinson's disease is the second most prevalent neurodegenerative disease worldwide, its cost in Brazil - South America's largest country - is unknown. Objective: The goal of this study was to calculate the average annual cost of Parkinson's disease in the city of São Paulo (Brazil), with a focus on disease-related motor symptoms. Subjects and methods: This was a retrospective, cross-sectional analysis using a bottom-up approach (ie, from the society's perspective)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29263657/impact-of-the-number-of-aspiration-risk-factors-on-mortality-and-recurrence-in-community-onset-pneumonia
#11
Shingo Noguchi, Kazuhiro Yatera, Tatsuji Kato, Yasuo Chojin, Yoshihisa Fujino, Kentaro Akata, Toshinori Kawanami, Noriho Sakamoto, Hiroshi Mukae
Introduction: The clinical significance of the number of aspiration risk factors in patients with pneumonia is unknown as yet. In the present study, we clarify the significance of the number of aspiration risk factors for mortality and recurrence in pneumonia patients. Methods: This study included 322 patients hospitalized with pneumonia between December 2014 and June 2016. We investigated associations between the number of aspiration risk factors present (orientation disturbance, bedridden, chronic cerebrovascular disease, dementia, sleeping medications and gastroesophageal disease) and 30-day and 6-month mortality, and pneumonia recurrence within 30 days...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29263656/application-of-haralick-texture-features-in-brain-18f-florbetapir-positron-emission-tomography-without-reference-region-normalization
#12
Desmond L Campbell, Hakmook Kang, Sepideh Shokouhi
Objectives: Semi-quantitative image analysis methods in Alzheimer's Disease (AD) require normalization of positron emission tomography (PET) images. However, recent studies have found variabilities associated with reference region selection of amyloid PET images. Haralick features (HFs) generated from the Gray Level Co-occurrence Matrix (GLCM) quantify spatial characteristics of amyloid PET radiotracer uptake without the need for intensity normalization. The objective of this study is to calculate several HFs in different diagnostic groups and determine the group differences...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29255352/role-of-adipose-tissue-in-facial-aging
#13
REVIEW
Uwe Wollina, Reinhard Wetzker, Mohamed Badawy Abdel-Naser, Ilja L Kruglikov
Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29255351/heart-type-fatty-acid-binding-protein-levels-in-elderly-diabetics-without-known-cardiovascular-disease
#14
Selvihan Beysel, Muhammed Kizilgul, Mustafa Ozbek, Mustafa Caliskan, Seyfullah Kan, Mahmut Apaydin, Ozgur Ozcelik, Erman Cakal
Background: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, inflammatory markers and subclinical atherosclerosis in elderly diabetics without overt CVD. Patients and methods: A total of 50 elderly diabetic patients without overt CVD and 30 age-, sex- and body mass index (BMI)-matched healthy controls were enrolled...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238181/the-link-between-weight-shift-asymmetry-and-gait-disturbances-in-chronic-hemiparetic-stroke-patients
#15
Andrzej Szopa, Małgorzata Domagalska-Szopa, Anetta Lasek-Bal, Amadeusz Żak
Introduction: While the asymmetry of body posture and the asymmetrical nature of hemiparetic gait in poststroke (PS) patients are well documented, the role of weight shift asymmetry in gait disorders after stroke remains unclear. Objective: We examined the association of weight-bearing asymmetry (WBA) between paretic and nonparetic lower limbs during quiet standing with the degree of deviation of hemiplegic gait from normal gait evaluated by the Gillette Gait Index (GGI) incorporating 16 distinct clinically important kinematic and temporal parameters in chronic PS patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238180/efficacy-comparison-of-intramedullary-nails-locking-plates-and-conservative-treatment-for-displaced-proximal-humeral-fractures-in-the-elderly
#16
Wei Ge, Qi Sun, Gen Li, Guanghua Lu, Ming Cai, ShaoHua Li
Purpose: The incidence of proximal humeral fractures is high in the elderly, and the superior management of these fractures remains a controversy. The study aims to compare clinical outcomes of intramedullary nails, locking plates and conservative treatment for the management of displaced proximal humeral fractures in the elderly. Patients and methods: In this prospective study, a total of 198 patients with 2- or 3-part proximal humeral fractures who received fixation of locking plates or intramedullary nails or conservative treatment were included...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238179/role-of-poly-adp-ribose-polymerase-1-and-cytokines-in-acute-renal-injury-in-elderly-chinese-patients-with-diabetes-mellitus
#17
Li Cao, Yan Liu, Li Zhang, Yanfei Wei
Objective: The primary objective of this study was to evaluate whether the polymorphism of poly (ADP-ribose) polymerase-1 (PARP-1) is involved as a potential risk factor in the development of acute renal injury in elderly Chinese patients with diabetes mellitus. Subjects and methods: In this pilot study, diabetic patients of either gender (aged ≥65 years) with a confirmed diagnosis of acute renal injury and individuals with no clinical symptoms of acute renal injury were enrolled at Nanxishan Hospital of Guangxi Zhuang Autonomous Region, China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238178/clinical-application-of-arthroscopy-assisted-minimally-invasive-therapy-in-chinese-elderly-with-type-iii-pilon-fracture
#18
Peiming Liu, Yong Guo, Ying Wen, Wei Wang
Objective: Pilon fracture is so complex that its therapy poses a great challenge to surgeons. Few studies have compared arthroscopy-assisted minimally invasive therapy and external fixation combined with limited internal fixation (EFLIF), and an optimal choice of surgical therapy remains unclear in patients with type III Pilon fracture. Moreover, to our knowledge, very few studies have specifically evaluated arthroscopy-assisted minimally invasive therapy in Chinese elderly with type III Pilon fracture...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238177/the-mediating-role-of-psychological-symptoms-on-falls-risk-among-older-adults-with-osteoarthritis
#19
Sumaiyah Mat, Chin Teck Ng, Farhana Fadzil, Faizatul Izza Rozalli, Maw Pin Tan
The purpose of this study was to investigate the role of fear of falling (FoF) and psychological symptoms in explaining the relationship between osteoarthritis (OA) symptom severity and falls. Individuals aged ≥65 years with ≥2 falls or ≥1 injurious fall over the past 12 months were included in the falls group, while volunteers aged ≥65 years with no history of falls over 12 months were recruited as controls. The presence of lower extremity OA was determined radiologically and clinically. Severity of symptoms was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238176/emotion-experience-and-frailty-in-a-sample-of-italian-community-dwelling-older-adults
#20
Anna Mulasso, Laura Argiolu, Mattia Roppolo, Danny Azucar, Emanuela Rabaglietti
Frailty increases individual vulnerability to external stressors and involves high risk for adverse geriatric outcomes. To date, few studies have addressed the role of emotion perception and its association with frailty in aged populations. This cross-sectional study aimed to explore whether a significant association between frailty and emotional experience exists in a sample of Italian community-dwelling older adults. Our sample consisted of 104 older adults (age 76±8 years; 59.6% women) living in Piedmont, Italy...
2017: Clinical Interventions in Aging
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