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Clinical Interventions in Aging

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https://www.readbyqxmd.com/read/29138544/early-postoperative-delirium-after-hemiarthroplasty-in-elderly-patients-aged-over-70-years-with-displaced-femoral-neck-fracture
#1
Yi-Hwa Choi, Dae-Hwan Kim, Tae-Young Kim, Tae-Wan Lim, Seok-Woo Kim, Je-Hyun Yoo
Purpose: Postoperative delirium is a risk factor for worse outcome after hip fracture surgery in elderly patients. Postoperative delirium is associated with anesthesia, postoperative pain, and patient factors. We investigated the incidence, predictors, and prognostic implications of post-operative delirium after hemiarthroplasty (HA) in elderly patients with femoral neck fracture. Patients and methods: A total of 356 consecutive patients aged >70 years who underwent HA for femoral neck fracture were enrolled...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29138543/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-after-intravitreal-ranibizumab-for-age-related-macular-degeneration
#2
Dimitrios Karagiannis, Irini Chatziralli, Konstantinos Kaprinis, Ilias Georgalas, Efstratios Parikakis, Panagiotis Mitropoulos
Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29133976/bisphosphonates-atherosclerosis-and-vascular-calcification-update-and-systematic-review-of-clinical-studies
#3
REVIEW
Carla Caffarelli, Andrea Montagnani, Ranuccio Nuti, Stefano Gonnelli
Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29123386/geroprotectors-as-a-therapeutic-strategy-for-copd-where-are-we-now
#4
REVIEW
Joanna Miłkowska-Dymanowska, Adam J Białas, Joanna Makowska, Aleksandra Wardzynska, Paweł Górski, Wojciech J Piotrowski
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29123385/clostridium-difficile-infection-in-the-elderly-an-update-on-management
#5
REVIEW
Tomefa E Asempa, David P Nicolau
The burden of Clostridium difficile infection (CDI) is profound and growing. CDI now represents a common cause of health care-associated diarrhea, and is associated with significant morbidity, mortality, and health care costs. CDI disproportionally affects the elderly, possibly explained by the following risk factors: age-related impairment of the immune system, increasing antibiotic utilization, and frequent health care exposure. In the USA, recent epidemiological studies estimate that two out of every three health care-associated CDIs occur in patients 65 years or older...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29123384/functional-outcomes-by-age-after-inpatient-stroke-rehabilitation-in-saudi-arabia
#6
Saad M Bindawas, Vishal Vennu, Hussam Mawajdeh, Hisham Alhaidary
Background: Among various risk factors, age has been identified as a nonmodifiable risk factor for stroke that influences functional outcomes after inpatient stroke rehabilitation in the developed world as well as in Saudi Arabia (SA). The demand for inpatient stroke rehabilitation services increases with population aging and stroke incidence; however, these services are limited in SA. Objective: To examine functional outcomes by age after inpatient stroke rehabilitation in SA...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29118576/psychosocial-therapy-for-parkinson-s-related-dementia-intervention-development
#7
Sheree A McCormick, Kathryn R McDonald, Sabina Vatter, Vasiliki Orgeta, Ellen Poliakoff, Sarah J Smith, Iracema Leroi
Background: Group-based psychosocial therapy, such as group Cognitive Stimulation Therapy, improves cognition and quality of life in people living with dementia. Neuropsychiatric symptoms and restricted mobility are common complications for people with Parkinson's-related dementia (PRD) and may limit access to, and participation in, group activities. This study describes the development of a condition-specific, home-based psychosocial therapy for people with PRD ready to be trialled in a clinical population...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29089750/inappropriate-pharmacological-treatment-in-older-adults-affected-by-cardiovascular-disease-and-other-chronic-comorbidities-a-systematic-literature-review-to-identify-potentially-inappropriate-prescription-indicators
#8
Ersilia Lucenteforte, Niccolò Lombardi, Davide Liborio Vetrano, Domenico La Carpia, Zuzana Mitrova, Ursula Kirchmayer, Giovanni Corrao, Francesco Lapi, Alessandro Mugelli, Alfredo Vannacci
Avoiding medications in which the risks outweigh the benefits in the elderly patient is a challenge for physicians, and different criteria to identify inappropriate prescription (IP) exist to aid prescribers. Definition of IP indicators in the Italian geriatric population affected by cardiovascular disease and chronic comorbidities could be extremely useful for prescribers and could offer advantages from a public health perspective. The purpose of the present study was to identify IP indicators by means of a systematic literature review coupled with consensus criteria...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29089749/relationship-of-quadriceps-muscle-power-and-optimal-shortening-velocity-with-angiotensin-converting-enzyme-activity-in-older-women
#9
Joanna Kostka, Joanna Sikora, Tomasz Kostka
BACKGROUND: The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women. SUBJECTS AND METHODS: Ninety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (Pmax) and optimal shortening velocity (υopt) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29089748/exploring-the-efficiency-of-the-tilburg-frailty-indicator-a-review
#10
REVIEW
Robbert Jj Gobbens, Jos Mga Schols, Marcel Alm van Assen
Due to rapidly aging human populations, frailty has become an essential concept, as it identifies older people who have higher risk of adverse outcomes, such as disability, institutionalization, lower quality of life, and premature death. The Tilburg Frailty Indicator (TFI) is a user-friendly questionnaire based on a multidimensional approach to frailty, assessing physical, psychologic, and social aspects of human functioning. This review aims to explore the efficiency of the TFI in assessing frailty as a means to carry out research into the antecedents and consequences of frailty, and its use both in daily practice and for future intervention studies...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29089747/bilingualism-as-a-strategy-to-delay-the-onset-of-alzheimer-s-disease
#11
REVIEW
Blanka Klimova, Martin Valis, Kamil Kuca
The purpose of this study is to explore original studies which provide evidence about the effects of bilingualism on the delay of the onset of dementia, specifically Alzheimer's disease (AD). A literature review was conducted in the world's acknowledged databases: Web of Science, Scopus, and MEDLINE. Altogether, 14 original studies focusing on the research topic were detected. These included six prospective cohort studies and eight retrospective studies. Both types of studies suggest different conclusions. The findings from the prospective cohort studies state that there is no association between bilingualism and the delay of the onset of AD, while the retrospective studies claim the opposite...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29081654/association-between-serum-%C3%AE-2-microglobulin-levels-and-frailty-in-an-elderly-chinese-population-results-from-rulas
#12
Zu-Yun Liu, Yan-Yu Shen, Li-Juan Ji, Xiao-Yan Jiang, Xiao-Feng Wang, Yan Shi
OBJECTIVE: To examine the association between serum β2-microglobulin (B2M) levels and frailty in an elderly Chinese population. DESIGN: A population-based cohort study. SETTING AND PARTICIPANTS: We used data on 1,663 elderly participants (aged 70-84 years) from the aging arm of the Rugao Longevity and Ageing study, a population-based observational two-arm cohort study conducted in Rugao, China. MEASUREMENTS: The serum B2M was measured with chemiluminescence immunoassay by a technician in the biochemistry laboratory of the Rugao People's Hospital...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29070944/evaluation-of-various-equations-for-estimating-renal-function-in-elderly-chinese-patients-with-type-2-diabetes-mellitus
#13
Mei Guo, Jian-Ying Niu, Xian-Wu Ye, Xiao-Jie Han, Ying Zha, Yang Hong, Hong Fang, Yong Gu
BACKGROUND: The clinical assessment of kidney function based on the estimated glomerular filtration rate (GFR) in older patients remains controversial. This study evaluated the concordance and feasibility of using various creatinine-based equations for estimating GFR in elderly Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional analytical study was conducted in 21,723 older diabetic patients (≥60 years) based on electronic health records (EHR) for Minhang District, Shanghai, China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29070943/the-incidence-of-depression-among-residents-of-assisted-living-prevalence-and-related-risk-factors
#14
Fidaa M Almomani, Wegdan Bani-Issa
AIM: This study aims to recognize and estimate the prevalence of depression and its risk factors among residents of assisted living facilities (ALs) in Jordan. BACKGROUND: Depression is commonly experienced by residents of ALs. The condition is, however, often misunderstood as a part of normal aging and may be overlooked by health care professionals. Little is known about the extent of depression and its risk factors among AL residents in Jordan. SUBJECTS AND METHODS: A national representative sample of 221 residents selected from all AL units across Jordan was recruited to the study...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29070942/odor-selectivity-of-hyposmia-and-cognitive-impairment-in-patients-with-parkinson-s-disease
#15
Cheng-Jie Mao, Fen Wang, Ju-Ping Chen, Ya-Ping Yang, Jing Chen, Juan-Ying Huang, Chun-Feng Liu
OBJECTIVE: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naïve patients with PD in the People's Republic of China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066877/response-to-teriparatide-in-chinese-patients-with-established-osteoporosis-osteocalcin-and-lumbar-spine-bone-mineral-density-changes-from-teriparatide-phase-iii-study
#16
Chunyan Lu, Yun Chen, Bin Zhang, Yu Chen, Fan Bai, Decai Chen
Teriparatide is the first anabolic agent for osteoporosis, and this analysis aimed to understand responses to teriparatide in Chinese patients with established osteoporosis in subgroups. In this Phase III study of teriparatide in China, 362 patients were randomized at a 2:1 ratio to receive subcutaneous teriparatide (20 μg/day) or intranasal salmon calcitonin (200 IU/day) for 24 weeks. Teriparatide treatment produced a significantly greater increase in lumbar spine bone-mineral density (LS-BMD) in postmenopausal women than calcitonin at the 24-week end point...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066876/comparative-study-of-two-different-respiratory-training-protocols-in-elderly-patients-with-chronic-obstructive-pulmonary-disease
#17
Sherin Hassan Mohammed Mehani
AIM: The aim of the present study was to compare threshold inspiratory muscle training (IMT) and expiratory muscle training (EMT) in elderly male patients with moderate degree of COPD. MATERIALS AND METHODS: Forty male patients with moderate degree of COPD were recruited for this study. They were randomly divided into two groups: the IMT group who received inspiratory training with an intensity ranging from 15% to 60% of their maximal inspiratory pressure, and the EMT group who received expiratory training with an equal intensity which was adjusted according to the maximal expiratory pressure...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066875/potentially-inappropriate-medications-in-hospitalized-older-patients-a-cross-sectional-study-using-the-beers-2015-criteria-versus-the-2012-criteria
#18
Xiaolin Zhang, Shuang Zhou, Kunming Pan, Xinran Li, Xia Zhao, Ying Zhou, Yimin Cui, Xinmin Liu
AIM: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. The purpose of the study was to investigate the prevalence of PIMs identified by the Beers 2015 and 2012 criteria in older patients in China and identify the correlates of PIMs. METHODS: This retrospective, cross-sectional study was conducted at Peking University First Hospital. The Beers 2015 and 2012 criteria were applied to evaluate PIMs among hospitalized patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066874/optimization-of-drug-therapy-in-elderly-individuals-admitted-to-a-geriatric-unit
#19
Antoine Piau, Yoann Huet, Adeline Gallini, Laurine Andre, Bruno Vellas, Fati Nourhashemi
BACKGROUND: A substantial share of adverse drug events involves inappropriate prescribing (IP). Specialized geriatric units are supposed to pay particular attention to prescribing appropriateness and to promoting a higher prescribing quality. OBJECTIVE: The objective of this study was to evaluate the reality of such assessment and optimization in real life (usual care) in a population of elderly individuals admitted to a geriatric unit. METHOD: This is an observational study including all older patients admitted to an acute geriatric unit over a 6-month period...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29066873/application-of-a-computer-based-neurocognitive-assessment-battery-in-the-elderly-with-and-without-hearing-loss
#20
Christiane Völter, Lisa Götze, Michael Falkenstein, Stefan Dazert, Jan Peter Thomas
INTRODUCTION: Due to demographic changes, the number of people suffering not only from dementia illness but also from hearing impairment with the need for hearing rehabilitation have increased noticeably. Even with the association between hearing, age, and cognitive decline being well known, this issue has so far not played an important role in daily clinical Ear Nose Throat settings. The aim of the present study was to evaluate the use of a computer-based battery of tests of neurocognitive abilities in older patients with and without hearing loss...
2017: Clinical Interventions in Aging
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