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Vascular Health and Risk Management

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https://www.readbyqxmd.com/read/29033578/right-ventricular-systolic-function-in-hypertensive-heart-failure
#1
O A Oketona, M O Balogun, A O Akintomide, O E Ajayi, R A Adebayo, T O Mene-Afejuku, O T Oketona, O J Bamikole
BACKGROUND: Heart failure (HF) is a major cause of cardiovascular admissions and hypertensive heart failure (HHF) is the most common cause of HF admissions in sub-Saharan Africa, Nigeria inclusive. Right ventricular (RV) dysfunction is being increasingly recognized in HF and found to be an independent predictor of adverse outcomes in HF. This study aimed to determine the prevalence of RV systolic dysfunction in HHF by several echocardiographic parameters. METHODOLOGY: One hundred subjects with HHF were recruited consecutively into the study along with 50 age and sex-matched controls...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28919772/anti-pcsk9-antibodies-for-the-treatment-of-heterozygous-familial-hypercholesterolemia-patient-selection-and-perspectives
#2
REVIEW
Alberico Luigi Catapano, Angela Pirillo, Giuseppe Danilo Norata
Heterozygous familial hypercholesterolemia (FH) is a genetic disorder characterized by high low-density lipoprotein cholesterol levels from birth, which exposes the arteries to high levels of atherogenic lipoproteins lifelong and results in a significantly increased risk of premature cardiovascular events. The diagnosis of FH, followed by an appropriate and early treatment is critical to reduce the cardiovascular burden in this population. Phase I-III clinical trials showed the benefit of proprotein convertase subtilisin kexin 9 inhibitors, both alirocumab and evolocumab, in these patients with an average low-density lipoprotein cholesterol reduction ranging from -40% to -60%...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28860793/evaluation-of-bleeding-in-patients-receiving-direct-oral-anticoagulants
#3
REVIEW
Erika L Hellenbart, Kathleen D Faulkenberg, Shannon W Finks
Direct oral anticoagulants (DOACs) are recognized by evidence-based treatment guidelines as the first-line option for the treatment of venous thromboembolism and prevention of stroke and systemic embolism in nonvalvular atrial fibrillation. As use of these anticoagulants has become favored over the past several years, reported bleeding-related adverse drug events with these agents has increased. In randomized clinical trials, all DOACs have a reduced risk for intracranial hemorrhage, while major and other bleeding results have varied among the agents compared to vitamin K antagonists...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28860792/endothelial-dysfunction-in-patients-with-buerger-disease
#4
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28860791/soluble-st2-correlates-with-some-indicators-of-right-ventricular-function-in-hypertensive-heart-failure
#5
Dike B Ojji, Sandrine Lecour, Olusoji M Adeyemi, Karen Sliwa
PURPOSE: ST2 receptor, which is a member of the Toll-like/interleukin-1 (IL-1) receptor family, has been found to be increased in the serum of patients 1 day after myocardial infarction. Several other studies have shown that soluble ST2 levels correlate with severity of heart failure (HF), left ventricular ejection fraction, creatinine clearance, B-type natriuretic peptide and C-reactive protein, and are predictors of mortality in HF. Most of these studies were not only limited to ischemic heart disease but also concentrated on left-sided HF...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28860790/evaluation-of-pain-during-endovenous-laser-ablation-of-the-great-saphenous-vein-with-ultrasound-guided-femoral-nerve-block
#6
Abdullah M Al Wahbi
BACKGROUND: Endoluminal laser ablation is now considered the method of choice for treating greater saphenous vein insufficiency. General anesthesia and peripheral nerve blocks with sedation have the risk of post-procedural delay in discharge and prolonged immobilization with the risk of deep vein thrombosis. The main pain experienced by patients during the procedure is during the laser ablation and the multiple needle punctures given along and around the great saphenous vein. The aim of our study was to evaluate the safety and efficacy of blocking the femoral nerve only under ultrasound-guidance without sedation, to reduce or prevent pain during injectable tumescent anesthesia in endovenous laser ablation of the greater saphenous vein...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28831263/cardiovascular-toxicities-of-bcr-abl-tyrosine-kinase-inhibitors-in-chronic-myeloid-leukemia-preventive-strategies-and-cardiovascular-surveillance
#7
REVIEW
Nazanin Aghel, Diego Hernan Delgado, Jeffrey Howard Lipton
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment and outcomes of chronic myeloid leukemia (CML). Despite their significant impact on the management of CML, there is growing evidence that TKIs may cause cardiovascular and/or metabolic complications. In this review, we present the current evidence regarding the cardiovascular safety profiles of BCR-ABL TKIs. Methodological challenges of studies that reported the cardiovascular safety of TKIs are discussed. We also propose management strategies for cardiovascular surveillance and risk factor modification during treatment with these agents...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28790836/evaluation-of-coronary-calcium-score-in-patients-with-normocalcemic-primary-hyperparathyroidism
#8
Patrícia Nunes Mesquita, Ana Paula Dornelas Leão Leite, Stella das Chagas Crisóstomo, Enio Veras Filho, Lucas da Cunha Xavier, Francisco Bandeira
RATIONALE: Given that the diagnosis of primary hyperparathyroidism (PHPT) is given at an increasingly less-symptomatic phase, and the literature data on the cardiovascular risk of patients with normocalcemic primary hyperparathyroidism (NPHPT) are controversial, the coronary calcium score (CCS), which is correlated with coronary artery disease, may be useful for clarifying the association between cardiovascular risk and NPHPT. OBJECTIVE: This research aims to describe the CCS and the clinical and laboratory variables of patients with NPHPT compared with a control group and to verify the presence of an association between NPHPT and CCS...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28769570/reversal-of-direct-oral-anticoagulants
#9
REVIEW
Mosaad Almegren
Reversal agents for direct oral anticoagulants (DOACs), including factor X inhibitors and direct thrombin inhibitors, are a major concern in clinical practice. After DOACs were introduced and became widely used as an alternative for vitamin K antagonists in the management of venous thromboembolism and nonvalvular atrial fibrillation, the need for effective reversal agents has increased, particularly for life-threatening bleeding episodes related to DOACs or to reverse medication effects during urgent interventions...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28761353/hypertension-and-blood-pressure-variability-management-practices-among-physicians-in-singapore
#10
Sajita Setia, Kannan Subramaniam, Jam Chin Tay, Boon Wee Teo
PURPOSE: There are limited data on blood pressure variability (BPV) in Singapore. The absence of updated local guidelines might contribute to variations in diagnosis, treatment and control of hypertension and BPV between physicians. This study evaluated BPV awareness, hypertension management and associated training needs in physicians from Singapore. MATERIALS AND METHODS: Physicians from Singapore were surveyed between September 8, 2016, and October 5, 2016. Those included were in public or private practice for ≥3 years, cared directly for patients ≥70% of the time and treated ≥30 patients for hypertension each month...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28761352/use-of-angiotensin-converting-enzyme-inhibitors-and-freedom-from-amputation-after-lower-extremity-revascularization
#11
Jared E Kray, Viktor Y Dombrovskiy, Todd R Vogel
OBJECTIVE: Angiotensin-converting enzyme inhibitors (ACEIs) have not been well evaluated in conjunction with lower extremity revascularization (LER). This study evaluated freedom from amputation in patients who underwent either an open (OPEN) or endovascular (ENDO) revascularization with and without utilization of an ACEI. MATERIALS AND METHODS: Patients who underwent LER were identified from 2007-2008 Medicare Provider Analysis and Review files. Demographics, comorbidities, and disease severity were obtained...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28744136/quick-reference-guide-to-apixaban
#12
REVIEW
Katherine Victoria Hurst, John Matthew O'Callaghan, Ashok Handa
Direct oral anticoagulants (DOACs) are being increasingly used in the clinical setting for patients at risk of venous thromboembolism (VTE) and/or stroke. These medications offer valued benefits for long-term use, including a fast onset of anticoagulation, fixed anticoagulation profile (and consequent prescription of specified doses) and no requirement for routine monitoring. Apixaban is a selective factor Xa inhibitor, approved for use in the prevention of stroke in patients with nonvalvular atrial fibrillation and in the prevention and treatment of acute VTE...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28740398/focusing-on-a-complete-blood-cell-parameter-mean-platelet-volume-levels-may-be-a-predictor-of-coronary-slow-flow
#13
Mücahid Yılmaz, Mustafa Necati Dağlı, Ökkeş Uku, Mehmet Nail Bilen, Hasan Korkmaz, Kenan Erdem, Ertuğrul Kurtoğlu
BACKGROUND: The relationship between increased mean platelet volume (MPV) and atherosclerosis is well known. In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV. PATIENTS AND METHODS: We studied 40 patients previously determined via coronary angiography as having NCA and 40 patients with CSF in the coronary blood stream, as identified by thrombolysis in myocardial infarction square...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28740397/eligibility-for-alirocumab-or-evolocumab-treatment-in-1090-hypercholesterolemic-patients-referred-to-a-regional-cholesterol-treatment-center-with-ldl-cholesterol-%C3%A2-70-mg-dl-despite-maximal-tolerated-ldl-cholesterol-lowering-therapy
#14
Vybhav Jetty, Charles J Glueck, Kevin Lee, Naila Goldenberg, Marloe Prince, Ashwin Kumar, Michael Goldenberg, Ishan Anand, Ping Wang
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors, Praluent (alirocumab [ALI]) and Repatha (evolocumab [EVO]) have been approved as adjuncts to the standard-of-care maximal-tolerated dose (MTD) of low-density lipoprotein cholesterol (LDLC)-lowering therapy (LLT), statin therapy, in heterozygous (HeFH) (ALI or EVO) or homozygous (EVO) familial hypercholesterolemia, or clinical atherosclerotic cardiovascular disease (CVD) where LDLC lowering is insufficient (both). Since LDLC lowering has been revolutionized by ALI and EVO, specialty pharmaceutical pricing models will be applied to a mass market...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28740396/antithrombotic-prophylaxis-of-atrial-fibrillation-in-an-italian-real-world-setting-a-retrospective-study
#15
Giuliano Ermini, Valentina Perrone, Chiara Veronesi, Luca Degli Esposti, Giuseppe Di Pasquale
OBJECTIVES: The aims of this study were to assess the prevalence of diagnosed atrial fibrillation (AF), the drug use in patients with AF in terms of antithrombotic (AT) strategies used and the compliance with treatment, and to describe the characteristics of patients affected by AF in relation to treatment. METHODS: The data collected were provided from databases of general practitioners (GPs) of the Local Health Unit of Bologna in Italy. From January 1, 2009, to December 31, 2012, all subjects aged ≥18 years followed by the 44 GPs enrolled in the study were evaluated, and the subjects with a diagnosis of AF were included in the analysis...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28721063/annual-deterioration-of-renal-function-in-hypertensive-patients-with-and-without-diabetes
#16
Jorge Polonia, André Azevedo, Miguel Monte, José A Silva, Susana Bertoquini
BACKGROUND: Chronic kidney disease (CKD) complicates hypertension and diabetes. Knowledge of the deterioration rate of CKD may anticipate adjustment of therapies with renal elimination. This study evaluates the rate of annual deterioration of renal function in hypertensive patients either with type 2 diabetes (DM2) or without it (non-DM) followed for 5 years and relates it with blood pressure (BP) and glycemic control. MATERIALS AND METHODS: Out of a total of 1924 patients, 1023 patients (594 non-DM and 429 DM2, 53% female, aged 62...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28670132/cost-utility-analysis-comparing-laparoscopic-vs-open-aortobifemoral-bypass-surgery
#17
RANDOMIZED CONTROLLED TRIAL
Anne Helene Krog, Mehdi Sahba, Erik M Pettersen, Torbjørn Wisløff, Jon O Sundhagen, Syed Sh Kazmi
OBJECTIVES: Laparoscopic aortobifemoral bypass has become an established treatment option for symptomatic aortoiliac obstructive disease at dedicated centers. Minimally invasive surgical techniques like laparoscopic surgery have often been shown to reduce expenses and increase patients' health-related quality of life. The main objective of our study was to measure quality-adjusted life years (QALYs) and costs after totally laparoscopic and open aortobifemoral bypass. PATIENTS AND METHODS: This was a within trial analysis in a larger ongoing randomized controlled prospective multicenter trial, Norwegian Laparoscopic Aortic Surgery Trial...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28670131/erratum-comparison-of-the-acute-phase-response-after-laparoscopic-versus-open-aortobifemoral-bypass-surgery-a-substudy-of-a-randomized-controlled-trial-erratum
#18
(no author information available yet)
[This corrects the article on p. 371 in vol. 12, PMID: 27713633.].
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28652760/worksite-based-cardiovascular-risk-screening-and-management-a-feasibility-study
#19
Raj Padwal, Mohammad Rashead, Jonathan Snider, Louise Morrin, Agnes Lehman, Norm Rc Campbell
BACKGROUND: Established cardiovascular risk factors are highly prevalent and contribute substantially to cardiovascular morbidity and mortality because they remain uncontrolled in many Canadians. Worksite-based cardiovascular risk factor screening and management represent a largely untapped strategy for optimizing risk factor control. METHODS: In a 2-phase collaborative demonstration project between Alberta Health Services (AHS) and the Alberta Newsprint Company (ANC), ANC employees were offered cardiovascular risk factor screening and management...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28652759/reference-values-assessment-in-a-mediterranean-population-for-small-dense-low-density-lipoprotein-concentration-isolated-by-an-optimized-precipitation-method
#20
COMPARATIVE STUDY
Bárbara Fernández-Cidón, Ariadna Padró-Miquel, Pedro Alía-Ramos, María José Castro-Castro, Marta Fanlo-Maresma, Dolors Dot-Bach, José Valero-Politi, Xavier Pintó-Sala, Beatriz Candás-Estébanez
BACKGROUND: High serum concentrations of small dense low-density lipoprotein cholesterol (sd-LDL-c) particles are associated with risk of cardiovascular disease (CVD). Their clinical application has been hindered as a consequence of the laborious current method used for their quantification. OBJECTIVE: Optimize a simple and fast precipitation method to isolate sd-LDL particles and establish a reference interval in a Mediterranean population. MATERIALS AND METHODS: Forty-five serum samples were collected, and sd-LDL particles were isolated using a modified heparin-Mg(2+) precipitation method...
2017: Vascular Health and Risk Management
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