journal
MENU ▼
Read by QxMD icon Read
search

Current Clinical Pharmacology

journal
https://www.readbyqxmd.com/read/28322168/pediatric-off-label-and-unlicensed-drug-use-and-its-implications
#1
Rajeshwari Gore, Preeta Kaur Chugh, Chakra Dhar Tripathi, Yangshen Lhamo, Sandhya Gautam
BACKGROUND: Worldwide, in the absence of standard pediatric prescribing information, clinicians often use medicines in children in a dosage form or for an indication that has not been approved for use. Inadequate clinical trials increase exposure to drugs that lack safety-efficacy data in pediatric population. Hence, off-label and unlicensed drug use must be regarded as a patient safety-issue that is known to be associated with increased risks of adverse drug reactions apart from under- or over-dosing due to lack of pharmacokinetic data...
March 17, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28294070/dutasteride-in-androgenetic-alopecia-an-update
#2
Tasleem Arif, Konchok Dorjay, Mohammad Adil, Marwa Sami
BACKGROUND: Androgenetic alopecia is a common condition characterized by thinning of scalp hair. Conversion of testosterone to dihydrotestosterone, a more potent androgen, by the enzyme 5-a-reductase is responsible for underlying pathogenesis. Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-alpha-reductase. Finasteride and minoxidil are the only approved drugs for androgenetic alopecia. Dutasteride has been demonstrated to be effective in several randomized, double-blind, placebo controlled trials in androgenetic alopecia...
March 10, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28245774/potential-usefulness-of-clopidogrel-pharmacogenetics-in-cerebral-endovascular-procedures-and-carotid-artery-stenting
#3
Jorge Duconge, Dagmar F Hernandez-Suarez
BACKGROUND: Previous reports have shown inadequate response to dual antiplatelet therapy (DAPT) with aspirin and clopidogrel in 5-30% of patients undergoing percutaneous coronary interventions (PCI), due mostly to clopidogrel resistance. This prevalence increases up to 66% in patients undergoing neurointerventional procedures. However, clinical significance of CYP2C19 genotypes in neurointerventional procedures or carotid artery stenting (CAS) is unknown. OBJECTIVE: The purpose of this review is to update our current knowledge and understanding of the pharmacogenetic basis for poor clopidogrel responsiveness in patients undergoing CAS and endovascular interventions as well as to explore usefulness of genotyping to reduce the rate of procedure-related thrombosis that results in ischemic complications...
February 27, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28176623/effect-of-cinnamomum-cassia-on-the-pharmacokinetics-and-pharmacodynamics-of-pioglitazone
#4
Sandhya Mamindla, Prasad Koganti, Nagaraju Ravouru, Bharathi Koganti
Back ground: Millions of people today use herbs either as food or in the form of medicine along with other medications. Many of the herbs can interact with these medications, causing either potentially dangerous side effects or improved or reduced benefits from the medication. OBJECTIVE: The present study was performed to determine the influence of cinnamon, on the pharmacokinetics and pharmacodynamics of pioglitazone. METHOD: Studies were conducted in normal and alloxan induced diabetic rats and rabbits with oral administration of selected doses of pioglitazone, cinnamon and their combination...
February 7, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28103775/interaction-of-antipsychotic-drugs-with-sucrase-kinetics-and-structural-study
#5
Narges Jafari, Helia Dehganpour, Nava Ghavanini, Hamidreza Mollasalehi, Dariush Minai-Tehrani
In patients with the Congenital Sucrase-Isomaltase Deficiency (CSID), who lack intestinal sucrase-isomaltase enzyme, a suspension of yeast sucrase is applied as a drug to compensate the enzyme deficiency. While antipsychotic drugs are used for treatment of schizophrenia, administering multiple drugs at the same time may counteract each other. In this study, the interaction between trifluoperazine and haloperidol as antipsychotic drugs on oral drug yeast sucrase was investigated. The results showed that both drugs could reduce sucrase activity and decrease the Vmax of the enzyme by non-competitive inhibition...
January 18, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28000556/therapeutic-approaches-blocking-glycan-synthesis-as-targeting-strategy-for-malaria
#6
Pollyanna Stephanie Gomes, Alexandre Morrot
Malaria annually infected million people around the world, especially in subtropical and tropical regions in the world. Thereby, the research effort is focused on new therapeutic targets to strike malaria, as drug resistance is one of the greatest challenges in malaria eradication. Carbohydrate recognition in Plasmodium-host interactions is one area for potential targets against disease. The glycan derivatives interfere with replication and invasion of Plasmodium falciparum. Sulfated glycosaminoglycans (GAGs) are known to block merozoite and sporozoite invasion...
December 20, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27908252/the-combination-of-new-immunotherapy-and-radiotherapy-a-new-potential-treatment-for-locally-advanced-non-small-cell-lung-cancer
#7
Paola Claudia Sacco, Paolo Maione, Cesare Guida, Cesare Gridelli
Lung cancer is the main reason of cancer death worldwide. About 30% of non-small-cell lung cancer (NSCLC) cases are diagnosed with locally advanced disease (stage III). This is a mixed population including patients who have far more extensive and bulky disease than others. Management of these patients continue to be a challenge; frequently, patients have both local recurrence and distant metastases in this stage and the prognosis is very poor with a 5-year overall survival estimated between 3% and 7% for inoperable disease...
December 1, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27592837/the-therapeutic-role-of-lamotrigine-and-topiramate-in-a-depressive-patient-with-anxiety-symptoms-and-cognitive-decline-neurometabolic-correlates
#8
Lutfu Hanoglu, Burak Yulug, Tansel Cakir, Kubra Sogukkanli, Ozge Arıcı Duz, Tamer Atasever
We describe here 67 years old women presented with symptoms of anxiety and cognitive impairment that responded well to the combined treatment of lamotrigine and topiramate. In contrast to recent data, we have shown that lamotrigine and topiramate treatment additively increased the cerebral glucose metabolism that was associated with complete resolution of the neuropsychiatric symptoms. Our findings indicate that the therapeutic effect of both agents involve a cortico-subcortical network and suggest the functional role of a bi-directional hippocampal-cingulate connectivity...
September 4, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27526697/ethosomes-as-vesicles-for-effective-transdermal-delivery-from-bench-to-clinical-implementation
#9
Nida Akhtar, Anurag Verma, Kamla Pathak
BACKGROUND: Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. A number of efforts have been put forward to find ways to get therapeutic actives overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have been investigated for its potential where high proportion of ethanol enables them to ameliorate transdermal delivery of several drugs in comparison to other carriers...
August 13, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27526696/humic-acids-as-therapeutic-compounds-in-lead-intoxication
#10
Klara Krempaska, Ladislav Vasko, Janka Vaskova
BACKGROUND: The toxicity of lead and its compounds is well known, causing anemia by inhibiting the synthesis of porphyrins. The neurotoxic effects, particularly in the young, alter the structure of cell membranes and DNA. Chronic exposure to lead has adverse effects on the body by disrupting the mechanisms of energy production and tissue damage, in particular in its links with thiol groups and competition for binding sites with zinc. OBJECTIVE: This review is therefore a description of the mechanism of lead toxicity as well as of possible interventions for the detoxification of the body...
August 13, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27450363/pramipexole-responsive-neck-numbness-the-therapeutic-role-of-dopamine-agonists-in-the-spinal-cord-indicating-to-a-common-spinal-pathophysiology-with-restless-leg-syndrome-rls
#11
Burak Yulug, Lutfu Hanoglu
BACKGROUND: There is still speculative data regarding the role spinal dopaminergic neurotransmission in restless leg syndrome (RLS). METHODS: We have evaluated the therapeutic role of pramipexole in a patient with cervical disc prolapsus who was exceptionally presented with neck restlessness Results: We have found that pramipexole leads to a significant improvement in restlessness symptoms in the neck region. DISCUSSION: The therapeutic role of pramipexole may not only suggest secondary deficits due to spinal pathologies but also indicate that specialized spinal dopaminergic neurons may play an important role in the pathogenesis of region specific restlessness symptomatology...
July 19, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27397091/polymorphism-in-endothelin-1-gene-an-overview
#12
Musa A Ahmed, Abir Rghigh
Endothelin-1, (ET-1, EDN1) is endogenous polypeptide demonstrates dominant vasoconstriction activity and mitogenic effect, on the heart it has positive inotropic and chronotropic properties, stimulates the sympathetic and the renin-angiotensin-aldosterone systems and modify homeostasis. The human ET-1 gene which consists of 6836 nucleotides located on chromosome 6p23-p24 produces Pre-pro-ET-1, which consequently cleaved to big-ET-1. The mature 21-amino acid ET-1 is generated by subsequent enzymatic cleavage of the big-ET-1...
June 30, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27784216/ivabradine-a-current-overview
#13
Kaushik Guha, Christopher J Allen, Adam Hartley, Rakesh Sharma
Ivabradine, acting on the funny channel (If) in the sino-atrial node, reduces myocardial oxygen demand without inducing hypotension. It was developed as a specific bradycardic agent in the 1980s, avoiding the adverse effects of more traditional antianginal agents (beta-blockers and calcium channel antagonists). This has seen significant interest in this first-in-class treatment, and is perceived as a promising drug in the management of ischaemic heart disease and heart failure. There has been much clinical research conducted exploring its role in these fields, to try to elucidate potential benefits and target patient group...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27748175/in-vitro-anti-urolithiasis-potentials-of-argemone-mexicana-l-leaves
#14
Ravi Kiran Chilivery, Sangilimuthu Alagar, Teepica P Darsini
BACKGROUND: The current study was performed to evaluate the anti-urolithiatic activity of Argemone mexicana L. leaves extracts as natural remedy to over come side effects problem due to the usage of modern synthetic medicine. METHODS: In vitro experiments (nucleation, aggregation and microscopic assay's) were performed to test the anti-urolithiasis activity of A. mexicana extracted using the four different solvents i.e. petroleum ether, chloroform, methanol, and water...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27748174/urine-comprehensive-drug-screen-low-birth-weight-and-withdrawal-symptoms-in-a-neonatal-unit-a-case-control-study
#15
Kam L Hon, Michael H M Chan, Ming H J Ng, Chi C Ho, Kathy Y C Tsang, Wing H Tam, Chung S Ho
OBJECTIVE: Maternal drug abuse may influence neonatal outcomes. We compared neonatal outcomes of patients with urine screened positive for commonly abused drugs (CAD) versus those who were screened negative, and reviewed the pattern of drugs detected at a university teaching hospital. METHODS: Urine samples collected from babies with suspected illicit drug exposure who were admitted to the neonatal unit were sent for comprehensive drug screen (CDS) performed by liquid chromatographytime- of-flight mass spectrometry (LC-TOF/MS)...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27697071/an-evaluation-of-the-efficacy-of-local-hemostatic-measures-in-dental-patients-taking-oral-anticoagulants-a-critical-review-of-the-literature-over-the-past-two-decades
#16
Salomao I M L Queiroz, Helenilton S Alves, Gleysson M de Assis, Thalita S Conceicao, Adriano R Germano, Jose S P da Silva
The increased risk of bleeding observed in patients on oral anticoagulant therapy (OAT) undergoing outpatient oral surgical procedures has been reported in the literature and remains a major concern in the care of these patients. This is still of great concern to dental surgeons that discontinuing OAT medication increases the risk of thromboembolism, while maintaining the therapeutic dose increases the risk of hemorrhage. Several local hemostatic measures have been used to control bleeding in patients on OAT...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27697039/therapeutic-effects-of-rivastigmine-and-alfa-lipoic-acid-combination-in-the-charles-bonnet-syndrome-electroencephalography-correlates
#17
Lutfu Hanoglu, Sultan Yildiz, Burcu Polat, Sema Demirci, Ahmet Mithat Tavli, Nesrin Yilmaz, Burak Yulug
BACKGROUND: Charles Bonnet Syndrome (CBS) is a rare clinical condition which is characterized by complex hallucinations in visually impaired patients. The pathophysiology of this disorder remains largely unknown, and there is still no proven treatment for this disease. In our study, we aimed to investigate the neural activity through Electroencephalography (EEG) power and evaluate the effect of rivastigmine in combination with alpha-lipoic acid on hallucination in two CBS patients with diabetic retinopathy...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27659611/an-8-year-retrospective-study-of-human-visceral-leishmaniasis
#18
Juliana F Barbosa, Sonia M de Figueiredo, Sandra Lyon, Rachel B Caligiorne
BACKGROUND: Visceral leishmaniasis (VL) is a zooanthroponosis affecting both rural and periurban areas, and can also spread into urban areas. VL has emerged in many countries in the world, presenting new cases in new countries of occurrence. Thus, studies concerning epidemiological aspects in different world regions are very meaningful. METHODS: With this purpose, this study analyzed 89 cases of VL, treated between June 2006 and June 2014 at Eduardo de Menezes Hospital (HEM), a Reference Center of Infectious Diseases situated in Belo Horizonte, in Minas Gerais state, Brazil...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27633039/relationships-between-metformin-paraoxonase-1-and-the-chemokine-c-c-motif-ligand-2
#19
Jordi Camps, Anna Hernandez-Aguilera, Anabel Garcia-Heredia, Noemi Cabre, Fedra Luciano-Mateo, Meritxell Arenas, Jorge Joven
Metformin is a biguanide used in the treatment of type 2 diabetes mellitus and obesity. The main mechanism of action is to decrease the intestinal glucose absorption and the hepatic glucose production, however, it does not influence insulin secretion. Metformin also increases the affinity of the insulin receptor, reduces high insulin levels and improves insulin resistance. Additionally, it promotes weight loss. Metformin is a pleiotropic compound but acts, largely, by activating 5 adenosine monophosphate (AMP)-activated protein kinase (AMPK)...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27633038/pharmacological-interactions-of-paraoxonase-1-pon1-a-hdl-bound-antiatherogenic-enzyme
#20
Abdolkarim Mahrooz
A growing interest exists in documenting the role of paraoxonase 1 (PON1) in different human diseases including, cardiovascular disease, obesity, diabetes mellitus, cancers, aging, and several neurological disorders. Three aspects of PON1 have attracted the attention of researchers: (1) hydrolyzing and detoxifying of toxic organophosphorous compounds such as nerve gases; (2) antioxidative activity in hydrolyzing oxidized phospholipids in high-density lipoprotein (HDL) and low-density lipoprotein (LDL); (3) interaction with various drugs...
2016: Current Clinical Pharmacology
journal
journal
41344
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"