journal
MENU ▼
Read by QxMD icon Read
search

Current Stem Cell Research & Therapy

journal
https://www.readbyqxmd.com/read/28820059/histone-modifications-in-aging%C3%AF-the-underlying-mechanisms-and-implications
#1
Yuan Wang, Quan Yuan, Liang Xie
Aging is characterized by time-dependent functional decline, which results in the reduced ability to cope with physiological challenges. The aging process can be affected by genetic factors, environment factors, epigenetic factors, and several stochastic factors. Epigenetic marker alteration during aging has been widely monitored and studied recently, since these epigenetic alterations are theoretically reversible. Histone post-translational modifications have been found to play a crucial role in epigenetic alteration during aging, among which histone methylation and histone acetylation are emerging as two well-documented modification methods...
August 17, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28721820/epigenetic-regulations-in-the-pathogenesis-of-periodontitis
#2
Yu Luo, Xian Peng, Dingyu Duan, Chengcheng Liu, Xin Xu, Xuedong Zhou
Periodontitis is a multifactorial infectious disease that affects a large population worldwide. It involves progressive alveolar bone loss, and if left untreated, can lead to the loosening and subsequent loss of teeth. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Aberrant host immune response is the key factor that leads to the destruction of periodontal tissues. Recently, the involvement of epigenetic modifications in the development of periodontitis has attracted increasing attentions...
July 18, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28721819/research-progress-of-the-types-and-preparation-techniques-of-scaffold-materials-in-cartilage-tissue-engineering
#3
Na Fu, Tengzhe Dong, Ai Meng, Zhaosong Meng, Bofeng Zhu, Yunfeng Lin
The management of chondral defects has been a challenge for a long time because of the poor self-healing capacity of articular cartilage. Many approaches ranging from symptomatic treatment to structural cartilage regeneration are not that successful with very limited satisfactory results. Chondral defects caused by tumor, trauma, infection, congenital malformations are very common in clinical trials. It seriously affects the patient's physical function and quality of life. Cartilage tissue engineering, which involves novel natural scaffolds, has emerged as a promising strategy for cartilage regeneration and repair...
July 18, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28707582/the-modulation-of-micrornas-in-tooth-root-development
#4
Ran Zhang, Tiejun Li
Tooth root development begins after the completion of tooth crown development, both of them undergo a series of interactions between epithelium and the adjacent mesenchymal cells. In contrast to the study in tooth crown formation, little is known about the regulatory mechanisms of tooth root development. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein expression through post-transcriptional mechanisms. They participate in a broad aspect of biological processes from the control of development to tumorigenesis...
July 13, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28641554/future-of-spermatogonial-stem-cell-culture-application-of-nanofiber-scaffolds
#5
Azar Shams, Neda Eslahi, Mansoureh Movahedin, Fariborz Izadyar, Hamidreza Asgari, Morteza Koruji
The spermatogonial stem cells (SSCs) are unique in mammals because they can transmit genetic information from generation to generation and it is of significant importance. In testes, Sertoli cells, peritubular myoid cells, Leydig cells and other interstitial cells contribute to the spermatogonial stem cell "niche". So, creation of niche in in vitro condition that mimics in vivo environment is essential to maintain functional characteristic of SSCs. Nanofiber matrices mimic the architecture and size scale of the natural extracellular matrix (ECM)...
June 22, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28637404/role-of-dna-and-rna-n6-adenine-methylation-in-regulating-stem-cell-fate
#6
Yunshu Wu, Chenchen Zhou, Quan Yuan
Epigenetic modifications have been evidenced to participate in eukaryotic stem cell fate decision. Among the most studied, 5-methylcytosine (m5C) and its derivatives are well-established epigenetic codes that play important roles in stem cell pluripotency and differentiation. Based on improved detection techniques, recent studies have succeeded in defining N6-adenine methylation (m6A) in eukaryotic DNA and RNA. The abundant m6A methylation in RNA was shown to be involved in multiple cellular metabolisms while the presence and functional potential of DNA m6A methylation in different species advanced our knowledge in the m6A-mediated biological processes...
June 21, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28641515/the-development-of-stem-cell-based-treatment-for-liver-failure
#7
Tiantian Zhu, Yuwen Li, Yusheng Guo, Chuanlong Zhu
Liver failure is a devastating clinical syndrome with a persistently mortality rate despite advanced care. According to the pathological histology, hepatic failure was divided into four categories: acute liver failure (ALF), subacute liver failure (SALF), acute - on - chronic liver failure (ACLF) and chronic liver failure (CLF). Orthotopic liver transplantation protected patients from hepatic failure. Yet, limitations including postoperative complications, high costs, and shortages of donor organs defect its application...
June 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28606044/the-formation-mechanism-of-hydrogels
#8
Liyan Lu, Shiliang Yuan, Jing Wang, Yun Shen, Shuwen Deng, Luyang Xie, Qixiang Yang
Hydrogels are degradable polymeric networks, in which cross-links play a vital role in structure formation and degradation. Cross-linking is a stabilization process in polymer chemistry that leads to the multi-dimensional extension of polymeric chains, resulting in network structures. By cross-linking, hydrogels are formed into stable structures that differ from their raw materials. Generally, hydrogels can be prepared from either synthetic or natural polymers. Based on the types of cross-link junctions, hydrogels can be categorized into two groups: the chemically cross-linked and the physically cross-linked...
June 12, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28595566/a-systemic-review-of-the-sources-of-adult-mesenchymal-stem-cells-and-their-suitability-in-musculoskeletal-applications
#9
Rhiannon Nancarrow-Lei, Pouya Mafi, Reza Mafi, Wasim Khan
Background: Adult mesenchymal stem cells (MSCs) were first isolated from bone marrow by Friedenstein in 1976. These cells were clonogenic, non-haematopoietic, and able to replicate extensively in vitro. The fields of regenerative medicine and tissue engineering have grown dramatically since their inception. In the decades since, MSCs have been identified from mesoderm-, endoderm- and ectoderm-derived tissues. In light of our ageing population, the need for effective cell-based therapies for tissue repair and regeneration is ever-expanding...
June 8, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28595567/cartilage-tissue-regeneration-the-roles-of-cells-stimulating-factors-and-scaffolds
#10
Kui Huang, Qing Li, Yong Li, Zhihao Yao, Daowen Luo, Pengcheng Rao, Jingang Xiao
Cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue damaged as a result of trauma or disease. As the propensity for healing and regenerative capabilities of articular cartilage are limited, its repair remains one of the most challenging issues of musculoskeletal medicine. Clinical treatments intended to promote the success and complete repair of partial- and full-thickness articular cartilage defects are still unpredictable. However, one of the most exciting theories is that treatment of damaged articular cartilage can be realized with cartilage tissue engineering...
June 7, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28578644/microrna-regulation-in-osteogenic-and-adipogenic-differentiation-of-bone-mesenchymal-stem-cells-and-its-application-in-bone-regeneration
#11
Binbin Li
Bone mesenchymal stem cells (BMSCs) are multipotent stromal cells providing a useful cell source for treating bone diseases and metabolic disorders. BMSCs fate determination and lineage progression are controlled by multiple cytokines, transcriptional factors, signaling pathways, and microRNAs (miRNAs). MiRNAs are small non-coding RNAs that inhibit the post-transcriptional gene expression or degrade their targets. They are closely involved in controlling the key steps of osteogenesis and adipogenesis of BMSCs...
June 4, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28554314/epigenetics-in-odontogenesis-and-its-influences
#12
Chuwen Li, Yujia Cui, Changchun Zhou, Jianxun Sun, Xuedong Zhou
Odontogenesis, including amelogenesis, dentin and pulp development and root formation, is fundamentally controlled by the genome. However, epigenetic factors have indispensable effects during odontogenesis. The regulation of cell differentiation, proliferation and apoptosis by epigenetic factors is fundamental in odontogenesis, with its appropriate procedure being vital in normal tooth development. Previous studies have shown that exogenous factors, such as the environment, that cause hypomethylation and hypermethylation in DNA may lead to dental differences in monozygotic twin pairs...
May 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28545380/from-stem-cell-biology-to-the-treatment-of-lung-diseases
#13
Dorina Esendagli, Aysen Gunel-Ozcan
The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases 'this scenario' is changed and injury progresses despite repair mechanisms or conventional treatment. This review summarizes the research on lung stem cells by giving an overview to the biology, function, niches and signaling that play role in lung stem cells and further to the regeneration of the lung...
May 23, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28545379/tissue-engineering-in-achilles-tendon-reconstruction-the-role-of-stem-cells-growth-factors-and-scaffolds
#14
D S Pillai, Bal S Dhinsa, Wasim Khan
Achilles tendon injuries are common, and present a challenge in the acute and chronic setting. There is significant morbidity associated with the injury and the numerous management strategies, as well as financial implications to the patient and the health service. To date, repair tissue from all methods of management fail to achieve the same functional and biomechanical properties as the native tendon. The use of tissue engineering technology may reduce morbidity, improve the biomechanical properties of repair tissue and reduce the financial burden...
May 23, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28530535/hair-regeneration-therapy-using-proteins-secreted-by-adipose-derived-stem-cells
#15
Hirotaro Fukuoka, Keigo Narita, Hirotaka Suga
Adipose-derived stem cells secrete various cytokines that promote hair growth. We have used adipose-derived stem cell-conditioned medium to treat alopecia and reported good results. In this article, we describe our experience of the hair regeneration therapy including characteristics of the commercialized conditioned medium, treatment methods, and future directions. Treatment using adipose-derived stem cell-conditioned medium is highly effective and may represent a new therapy for alopecia.
May 21, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28494722/adult-stem-cells-and-hydrogels-for-cartilage-regeneration
#16
Lei Wang, Chenglong Huang, Qing Li, Lin Liu, Shihong Luo, Jingang Xiao
Cartilage tissue engineering is emerging as a therapeutic approach for the repair and regeneration of cartilage tissue defects resulting from trauma and disease. It is still essential to explore approaches that employ combinations of ideal seed cells, biomaterials, and growth factors to repair defect areas because cartilage lacks spontaneous regenerative capabilities and traditional treatments do not fully satisfy clinical requirements. The purpose of this review is to summarize key advances in this area with an emphasis on adult stem cells because these cells possess a self-renewal ability and the potential for multi-directional differentiation when cultured under appropriate conditions, such as chondrocyte differentiation to synthesize cartilage-specific matrix proteins...
May 11, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28486918/the-influence-of-inflammatory-cytokines-on-the-proliferation-and-osteoblastic-differentiation-of-mscs
#17
Juan Liu, Bin Chen, Fuhua Yan, Wenrong Yang
Mesenchymal stem cells (MSCs) have been widely researched for the function of wound repair and bone regeneration. Numerous evidence have proved that MSCs can differentiate towards osteoblasts, and enhance bone formation, and then directly promote the process of bone regeneration. The researchers' interesting of MSCs focus on the potential of differentiating towards osteoblasts. They suggest that these applications can be significantly influenced by different kinds of inflammatory cytokines. In particular, in the process of bone regeneration, MSCs and inflammatory cytokines interact with each other, and promote the process of bone healing ...
May 8, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28474542/up-to-date-clinical-trials-of-hair-regeneration-using-conditioned-media-of-adipose-derived-stem-cells-in-male-and-female-pattern-hair-loss
#18
Hyoseung Shin, Chong Hyun Won, Woon-Kyung Chung, Byung-Soon Park
The primary roles of mesenchymal stem cells (MSCs) are to maintain the stem cell niche, facilitate recovery after injury, and ensure healthy aging and the homeostasis of organ and tissues. MSCs have recently emerged as a new therapeutic option for hair loss. Since adipose-derived stem cells (ADSCs) are the most accessible sources of MSCs, ADSC-based hair regeneration is currently under investigation. Besides replacing degenerated cells in affected organs, ADSCs exhibit their beneficial effects through the paracrine actions of various cytokines and growth factors...
May 4, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28464788/significance-of-cd34-negative-hematopoietic-stem-cells-and-cd34-positive-mesenchymal-stem-cells-a-valuable-dimension-to-the-current-understanding
#19
Chandra Viswanathan, Rohit Kulkarni, Abhijit Bopardikar, Sushilkumar Ramdasi
The strategy to expand CD34+ hematopoietic stem cells (HSCs) is being increasingly practiced to meet the demand for a higher cell dose. This is for hematopoietic reconstitution in patients with higher body weights. Interestingly, literature reports show that CD34- (CD34 negative) cell population also possesses the potential to reconstitute the bone marrow & in a certain phase, converts them into CD34+ phenotype. The current practice of positive selection of CD34+ HSCs by eliminating rest of the (CD34-) population for expansion could probably pose a risk of losing valuable HSCs with good reconstitution potentials...
May 1, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28464787/directed-differentiation-and-paracrine-mechanisms-of-mesenchymal-stem-cells-potential-implications-for-tendon-repair-and-regeneration
#20
Bingyu Zhang, Qing Luo, Alexander Halim, Yang Ju, Yasuyuki Morita, Guanbin Song
Tendon is composed of connective tissue, is able to retract with high tensile force, and plays a significant role in musculoskeletal motion. However, inappropriate physical training or accidents often result in tendon injuries. So far, the functional healing of injured tendon is still a great challenge in orthopedics. Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, including tenocytes. The plasticity of MSCs gives rise to the chance of improved healing of injured tendons and even tissue-engineered tendons...
May 1, 2017: Current Stem Cell Research & Therapy
journal
journal
41337
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"