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Current Stem Cell Research & Therapy

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https://www.readbyqxmd.com/read/29676233/chimeric-antigen-receptor-t-cell-based-immunotherapy-for-cancer
#1
Feng Li, Tengfei Zhang, Ling Cao, Yi Zhang
Cancer immunotherapy, a new weapon against cancers by harnessing the patient's own immune system, potentiates an extended remission and possibly a cure for cancer. T cells genetically engineered with chimeric antigen receptor (CAR) vectors can specifically target the surface antigen of cancer cells and kill them in an MHC-independent manner. CD19 is extensively expressed on cancerous cells in B cell malignancies. To target this antigen, CAR T cells have gained great success in treating patients with B cell leukemia and lymphoma...
April 19, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29663898/electrospun-fibers-for-cartilage-tissue-regeneration
#2
Guo Li, Sirong Shi, Shiyu Lin, Tengfei Zhou, Xiaoru Shao, Qiao Huang, Bofeng Zhu, Xiaoxiao Cai
BACKGROUND: Due to its poor self-repair ability, the cartilage injury has been a great challenge in clinical work. OBJECTIVE: The conventional therapies for cartilage injury mostly form fibrocartilage with weaker strength and flexibility compared to natural cartilage. The development of tissue engineering technology provides a new approach for cartilage repair and regeneration. RESULTS: An appropriate scaffold is one of key factors in cartilage tissue engineering...
April 17, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29637866/stem-cell-interventions-for-bone-healing-fractures-and-osteoporosis
#3
Anita Sanghani-Kerai, Dara McCreary, Henry Lancashire, Liza Osagie, Melanie Coathup, Gordon Blunn
With the ageing population, musculoskeletal conditions are becoming more inherent. Delayed union is defined as a slower than normal fracture healing response, with no healing after 4 to 6 months; however, union is anticipated given sufficient time. In the context of delayed/non-union, fragility fractures in osteoporotic populations carry significant patient morbidity and socioeconomic costs. Multiple mechanisms hinder fracture healing in osteoporotic patients, imbalanced bone remodelling leads to impaired bone microarchitecture due to reduced osteoblast number and activity and as such, callus formation is diminished...
April 10, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623851/mesenchymal-stem-cells-derived-exosomes-a-possible-therapeutic-strategy-for-osteoporosis
#4
Yue Li, Daxiang Jin, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren, Zenglin Xiao
Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis, inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based tissue engineering therapy of osteoporosis...
April 3, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29532760/efficacy-and-safety-of-autologous-cell-based-therapy-in-patients-with-no-option-critical-limb-ischaemia-a-meta-analysis
#5
Fadilah S Abdul Wahid, Nor Azimah Ismail, Wan Fariza Wan Jamaluddin, Nor Asiah Muhamad, Mohamad Mohamad Azim Mohamad Idris, Nai Ming Lai
BACKGROUND: Revascularisation therapy is the curent gold standard of care for critical limb ischaemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogeneic therapies such as the use of autologous cell-based therapy (CBT) have been examined, but the results of individual trials were inconsistent. OBJECTIVE: To pool all published studies that compared the safety and efficacy of autologous CBT derived from different sources and phenotypes with non cell-based therapy (NCT) in CLI patients...
March 13, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29473525/oral-mucosal-stem-cells-human-immature-dental-pulp-stem-cells-and-hair-follicle-bulge-stem-cells-as-adult-stem-cells-able-to-correct-limbal-stem-cell-deficiency
#6
Nada Tarek Hassan Mohamed, Neveen Ahmed AbdelAziz
Adult stem cells are somatic stem cells distributed all over the body. They represent a promising future for regenera-tive medicine because of their multiple advantages as they are widely available, accessible, easily stored and manipulated to a wide range of cells and with minimal invasive extraction. This review describes three examples of adult stem cells: oral mucosal epithelial stem cells, human immature dental pulp stem cells and hair follicle bulge stem cells that show an ability to correct limbal stem cell deficiency, their isolation and cultivation methods, feeder layers, carriers, markers expressed, successfulness to regenerate the ocular surface and mimic the corneal function in LSCD...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29468980/updates-on-gmscs-treatment-for-autoimmune-diseases
#7
Feng Huang, Zhong-Min Liu, Song Guo Zheng
BACKGROUND: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. OBJECTIVE: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases...
February 20, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29446747/crispr-cas9-genome-editing-a-promising-tool-for-therapeutic-applications-of-induced-pluripotent-stem-cells
#8
Yanli Zhang, Danuta Sastre, Feng Wang
Induced pluripotent stem cells hold tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. The revolutionary technology for genome editing known as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) system is recently recognized as a powerful tool for editing DNA at specific loci...
February 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29412118/antibody-administration-for-bone-tissue-engineering-a-systematic-review
#9
Sepanta Hosseinpour, Maryam Rezai Rad, Arash Khojasteh, Homa Zadeh
BACKGROUND: Currently, antibodies are progressively applied in medicine for different purposes from diagnosis to treatments. Over twenty monoclonal antibodies utilized for many therapeutic reasons from therapy of cancers, immune disorders, and osteoporosis to localized bony defects. In addition, therapeutic antibodies represented various findings in bone tissue engineering. OBJECTIVES: The current study aims to systematically review the available literature on antibody assisted bone regeneration in animal models...
February 6, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29380704/the-role-of-ageing-and-gender-in-musculoskeletal-stem-cell
#10
Amir H Gahanbani Ardakani, Wasim S Khan
BACKGROUND: Multipotent mesenchymal stromal cells (MSCs) are the most common type of stem cell used in the regeneration of skeletal tissue. These cells have multipotent, angiogenic, paracrine, anti-fibrotic and immunological properties. They are readily available, easily isolated and have many therapeutic applications. The ageing population is on the increase and with this comes an upsurge in medical conditions that may benefit from novel stem cell-based therapies to treat ageing-associated diseases...
January 29, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29380705/the-use-of-novel-electrospun-scaffolds-in-musculoskeletal-tissue-engineering-a-focus-on-the-rotator-cuff
#11
Navraj S Nagra, Edward T Stace, Saket Tibrewal, Wasim Khan, Andrew J Carr
Rotator Cuff tears affect 15% of 60 years olds and carry a significant social and financial burden. Current operative techniques and repair adjuncts are associated with unacceptably high failure rates, stimulating investigation into novel tissue engineering for regenerative medicine (TERM) approaches in the field of rotator cuff surgery. In this review we explore the most recent advances in the field of electrospinning, focussing on proposed tissue-engineered solutions in the rotator cuff niche. Methods The MEDLINE/PubMed database was reviewed for English language papers and publication date within the last 5 years, using the search string "electrospinning AND tendon"...
January 28, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29303079/stem-cells-transplantation-in-the-treatment-of-patients-with-liver-failure
#12
Ya-Chao Tao, Meng-Lan Wang, En-Qiang Chen, Hong Tang
BACKGROUND: Liver failure is a life-threatening liver disease encompassing severe acute deterioration of liver function. Emergency liver transplantation is the only curative treatment for liver failure, but is restricted by the severe shortage of organ donors. Stem cell, including embroyonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells and hepatic progenitor cells, have capacity to proliferate and differentiate and could be used in a variety of liver diseases including hereditary liver diseases, cirrhosis and liver failure...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29285998/structure-function-evaluation-of-stem-cell-therapies-for-spinal-cord-injury
#13
Fuguo Zhang
BACKGROUND: Spinal cord injuries (SCI) are prevalent, devastating for quality and expectancy of life, and cause heavy economic burdens. Stem cell therapies hold promise in complete structural and functional restoration of SCI. OBJECTIVE: This review focuses on the methods currently used to evaluate the stem cell therapies for SCI. RESULTS: Various kinds of stem cells involving embryonic stem cells (ESCs), bone marrow stromal cells (BMSCs), neural stem cells (NSCs) and induced pluripotent stem cells (iPSCs) are extensively used in regenerative research of SCI...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29284397/stem-progenitor-cells-and-biodegradable-scaffolds-in-the-treatment-of-retinal-degenerative-diseases
#14
Yuyao Wang, Dandan Zhang, Bingqiao Shen, Yi Zhang, Ping Gu
BACKGROUND: Visual impairment caused by retinal degeneration is primarily attributed to the irreversible degradation of retinal neurons or the adjacent retinal pigment epithelium (RPE). No efficient clinical therapies to restore or improve visual ability are currently available. Cell therapy has been touted as a promising strategy to overcome this challenge. OBJECTIVE: This review aims to depict the effects and progresses of using stem/progenitor cells and biodegradable scaffolds in the treatment of retinal degenerative diseases, as well as discuss the challenges and opportunities of cell-based therapy for the future clinical application...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28914207/a-systematic-review-and-meta-analysis-of-clinical-trials-of-mesenchymal-stem-cell-therapy-for-cartilage-repair
#15
Aditya Borakati, Reza Mafi, Pouya Mafi, Wasim S Khan
BACKGROUND: Osteoarthritis (OA) is a major global burden creating significant morbidity worldwide. Current curative therapies are expensive, challenging to access and have significant risks, making them infeasible and difficult in many cases. Mesenchymal stem cells (MSCs) can be applied to joints and may regenerate the cartilage damaged in OA, this therapy may be advantageous to existing treatments. OBJECTIVE: We systematically reviewed clinical trials of MSCs for cartilage repair and provide an overview of the literature in this area here...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29359678/different-sources-of-stem-cells-and-their-application-in-cartilage-tissue-engineering
#16
Quanquan Ma, Jinfeng Liao, Xiaoxiao Cai
BACKGROUND: The articular cartilage is unique in that it contains only a single type of cell and shows poor ability for spontaneous healing. Currently, approaches for treating cartilage defects include surgical and nonsurgical approaches, as well as cartilage tissue engineering. For standard cartilage tissue engineering, three elements are required, i.e., a scaffold, growth factors, and seed cells. With advancements in in stem cell research, the main sources of cells for cartilage tissue engineering are embryonic and mesenchymal stem cells, which have been shown to be promising alternatives in recent years...
January 22, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29336267/stem-cells-derived-from-amniotic-fluid-a-potential-pluripotent-like-cell-source-for-cellular-therapy
#17
Thamil Selvee Ramasamy, Vithya Velaithan, Yelena Yeow, Fazlul H Sarkar
BACKGROUND: Regenerative medicine aims to provide therapeutic treatment for disease or injury, and cell-based therapy is a newer therapeutic approach that the conventional medicine cannot do. The ethical issues rose by the utilisation of human embryonic stem cells (hESC) and the limited capacity of adult stem cells, however, hinder the application of these stem cells in regenerative medicine. Recently, isolation and characterisation of c-kit positive cells from human amniotic fluid, which possess intermediate characteristics between hESCs and adult stem cells, provided a new approach towards realising their promise for fetal and adult regenerative medicine...
January 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29295700/physical-cues-drive-chondrogenic-differentiation
#18
Qi Zhang, Shiyu Lin, Jinfeng Liao, Xiaoxiao Cai
BACKGROUND: Cellular differentiation occurs in a complicated microenvironment containing multiple components including soluble factors and physical cues. In addition to biochemical composition, physical cues are also crucial in determining cellular behaviors. OBJECTIVE: To better understand the interaction between physical signals and cells, we discuss the effects of physical cues on cellular behaviors, especially chondrogenic differentiation in vitro. Furthermore, the mechanisms by which these physical signals are transmitted from the extracellular matrix into the cell are also considered...
January 2, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29461175/editorial-epigenetics-in-oromaxillafacial-development-and-disease
#19
EDITORIAL
Liwei Zheng
No abstract text is available yet for this article.
2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29310565/editorial-epigenetic-regulation-on-stem-cells-fate-and-regeneration
#20
EDITORIAL
Liwei Zheng
No abstract text is available yet for this article.
2018: Current Stem Cell Research & Therapy
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