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Current Stem Cell Research & Therapy

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https://www.readbyqxmd.com/read/28088893/intervention-for-cardiac-repair-a-clinical-perspective
#1
Hui Na Tan, Zhe Yuan Tay, Boon Seng Soh
Cardiovascular disease remains the leading cause of death worldwide. Damage to the heart resulting from cardiovascular disease leads to gradual loss of function and reduced quality of life. Cardiac injury is particularly debilitating, more so than injury to any other organ given our current inability to either generate new and functional cardiac tissue or to mimic the actions of the heart using external devices. Advances in the field of stem cells and genetics have paved the way for the development of a variety of novel therapies...
January 12, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28042766/insights-into-the-regulation-of-yap-taz-from-cellular-systems-and-mouse-models
#2
Wei Du, Wen Du, Mian Wan, Xuedong Zhou, Xin Xu, Liwei Zheng
The Hippo signaling pathway serves as a main regulator of tissue growth and organ size through the moderation of cell cycle dynamics across many different species. In mammals, the two downstream transcriptional regulators of this pathway are Yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ). Recent studies found in addition to the core Hippo signaling pathway, other signaling pathways can also regulate YAP/TAZ activity, either directly or through crosstalk with the Hippo pathway...
January 2, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28025937/dna-methylation-is-correlated-with-pluripotency-of-stem-cells
#3
Ruofeng Wang, Tianqing Li
Pluripotency of stem cells is an important scientific issue and is attracting great interests for the broader community, especially for regenerative medicine field. Pluripotent stem cells (PSCs) in mammalians are defined as naive- and primed-states according to their varieties in cellular, molecular, epigenetic and functional states, respectively. Numerous studies have shown that pluripotency and naive characteristics of PSCs are closely associated with cell DNA methylation. However, the mechanisms, which are involved in methylation modifications of naive ground, are still one of important scientific issues for primate naive PSCs because of lack of widely accepted culture condition...
December 26, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28025936/current-status-of-leukemia-cytotherapy-exploitation-with-immune-cells
#4
Haiyan Bao, Depei Wu
With the development of chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis of leukemia patients has been improved greatly in the past few decades. However, relapsed and refractory leukemia is still the major cause of mortality in leukemia patients. Besides, advancing age, poor performance status and severe co-morbidities limit the applicability of cytotoxic chemotherapy in certain groups of leukemia patients. Novel agents including nucleoside analogues, kinase inhibitors targeting oncoproteins and monoclonal antibodies are under investigation for the management of leukemia...
December 26, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28002993/epigenetics-bone-remodeling-and-osteoporosis
#5
Shaoqing Yang, Xiaohong Duan
Epigenetic regulation, including modifications of DNA, histone proteins and non-coding RNAs, play an important role in the regulation of gene expression and keep the heritable traits of progeny cells without changing DNA sequence. Recent years, epigenetic regulation of bone homeostasis are widely investigated and considered as a vital factor during the differentiation and function of osteoblasts, osteoclasts and osteocytes. Osteoporosis is a common degenerative bone disease which is characterized with decreased bone strength and increased risk of fracture...
December 21, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28071582/reporter-mice-used-for-dentinogenesis-study
#6
Jing Yang, Ling Ye, Fanyuan Yu, Feng Lou, Fanzi Wu, Dian Chen, Chenglin Wang
Dentinogenesis is a long and complex process not only in tooth development, but also throughout the whole life. Reporter mice provided us a preferred model to study the dentin formation with characteristics of high sensitivity, visualization, and reliability, which makes the long-term and intricate period of dentinogenesis much clear. With the advent of different gene reporters, genetic engineering methods, and tissue specific promoters, various reporter mice can be created to solve different problems. To this end, understand the fundamental concepts and characteristics is the prerequisite to use this advanced tool...
December 1, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27897123/the-epigenetic-regulation-in-tooth-development-and-regeneration
#7
Yao Lin, Liwei Zheng, Li Fan, Wei Kuang, Rui Guo, Jiong Lin, Jiahua Wu, Jiali Tan
Teeth are formed through sequential and reciprocal interactions between epithelial and mesenchymal tissues and they are essential to physical and psychological health. In-depth knowledge of tooth development, from histology to the underlying mechanisms, is necessary for the regeneration of lost teeth. Therefore, the review firstly introduced tooth development, and summarized the use of tooth-derived stem cells. To date, epigenetic regulation has been shown to have roles in numerous activities, including odontogenesis...
November 29, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27903221/in-vitro-generated-mesenchymal-stem-cells-suitable-tools-to-target-insulin-dependent-diabetes-mellitus
#8
Shruti D Dave, Patel C N, Patel J V, Thakkar U G
A synergy of a pre-accumulated genes with an autoimmunity advancing to slow abolition of pancreatic beta-cells causes insulin deficiency and results enrooting insulin dependent diabetes mellitus (IDDM). As per WHO data worldwide about 150 million people are diabetic and the number may rise to more than double by the year 2025. Any absolute cure for IDDM is not available yet, and one of the credible advent in the field include cell-based therapy. At this conjecture, mesenchymal stem cells (MSC) seems to have a specific and beneficial characteristics due to their in vivo as well as in vitro potential to mimic a pancreatic endocrine phenotype and immune-regulatory actions...
November 21, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27842480/mesenchymal-stem-cells-as-a-source-of-dopaminergic-neurons-a-potential-cell-based-therapy-for-parkinson-s-disease
#9
Katari Venkatesh, Dwaipayan Sen
Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect in the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strategies that replace damaged neurons with new/functional dopaminergic neurons. Although several research groups have reported the generation of neural precursors/neurons from human/mouse embryonic stem cells and mesenchymal stem cells, the latter is considered to be an attractive therapeutic candidate because of its high capacity for self-renewable, no adverse effect to allogeneic versus autologous transplants, high ethical acceptance and no teratoma formation...
November 14, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27804866/therapeutic-potential-future-perspective-and-challenges-of-cancer-stem-cells-in-translational-oncology-a-critical-review
#10
Gaurav Shukla, Amit Kumar Srivastava, Rahul Patidar, Piush Khare, Rajiv Saxena
Stem cell research is a rapidly developing field that offers effective treatment for a variety of malignant and non-malignant diseases. Stem cell is a regenerative medicine associated with the replacement, repair, and restoration of injured tissue. Stem cell research is a promising field having maximum therapeutic potential. Cancer stem cells (CSCs) are the cells within the tumor that posse's capacity of self-renewal and have root cause for the failure of traditional therapies leading to re-occurrence of cancer...
October 28, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27784228/a-perspective-on-stem-cells-as-biological-systems-that-produce-differentiated-osteoblasts-and-odontoblasts
#11
Shahrul Hisham Zainal Ariffin, Thanaletchumi Manogaran, Intan Zarina Zainol Abidin, Rohaya Megat Abdul Wahab, Sahidan Senafi
Stem cells (SCs) are capable of self-renewal and multilineage differentiation. Human mesenchymal stem cells (MSCs) and haematopoietic stem cells (HSCs) which can be obtained from multiple sources, are suitable for application in regenerative medicine and transplant therapy. The aim of this review is to evaluate the potential of genomic and proteomic profiling analysis to identify the differentiation of MSCs and HSCs towards osteoblast and odontoblast lineages. In vitro differentiation towards both of these lineages can be induced using similar differentiation factors...
October 26, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27781940/mesenchymal-stem-cells-in-renal-ischemia-reperfusion-injury-biological-and-therapeutic-perspectives
#12
Honglin Hu, Cong Zou
Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising treatment for renal IRI. Mesenchymal stem cells (MSCs) have the ability to differentiate into tissues of mesodermal lineages. MSCs are under intensive study as potential therapeutic strategy for renal IRI...
October 24, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27991403/editorial-future-directions-for-stem-cell-banking-and-therapy
#13
EDITORIAL
Todd McAllister, Anthony Atala
No abstract text is available yet for this article.
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27633037/the-therapeutic-potential-of-differentiated-lung-cells-from-embryonic-stem-cells-in-lung-diseases
#14
Mohammad Reza Mokhber Dezfouli, Sirous Sadeghian Chaleshtori, Mohammad Mehdi Dehghan, Hamid Tavanaeimanesh, Hossein Baharvand, Yaser Tahamtani
Lung diseases cause great morbidity and mortality. The choice of effective medical treatment is limited and the number of lung diseases are difficult to treat with current treatments. The embryonic stem cells (ESCs) have the potential to differentiate into cell types of all three germinal layers, including lung epithelial cells. So they can be a potential source for new cell therapies for hereditary or acquired diseases of the airways and lungs. One method for treatment of lung diseases is cell therapy and the use of ESCs that can replace the damaged epithelial and endothelial cells...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27593447/role-of-stem-cells-in-colorectal-cancer-progression-and-prognostic-and-predictive-characteristics-of-stem-cell-markers-in-colorectal-cancer
#15
Mikhail Fedyanin, Popova Anna, Polyanskaya Elizaveta, Tjulandin Sergei
In the last decade, an increasing number of studies on tumor stem cell theory stating that there is only a small fraction of tumor cells capable of inducing tumor growth have been published. These cells can not only differentiate into more mature tumor cells, but also can maintain their own pool, that is the capacity for self-renewal. There are distinct subpopulations of cells within a tumor that express different combinations of stem cell markers and have different functions. The following markers are typically considered as markers of colorectal adenocarcinoma stem cells: CD133, CD144, CD24, CD166, CD44, CD29, ALDH1, LGR5, and CXCR4...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27538403/properties-of-cell-sources-in-tissue-engineered-three-dimensional-oral-mucosa-model-a-review
#16
Nurul Hafizah Mohd Nor, Zurairah Berahim, Azlina Ahmad, Thirumulu Ponnuraj Kannan
Oral mucosa is a mucous membrane lining the oral cavity. Its main function is to protect the deeper structures against the external factors; thermal, chemical, mechanical and biological stimuli. Apart from that, it also plays a significant role during mastication, deglutition and speech. Some oral diseases or injuries to oral mucosa lead to impairment of the oral functions and aesthetics which eventually result in permanent defect of oral mucosa. In order to overcome this defect, different approaches for the development of reconstructed oral mucosa models have been employed including skin/autologous grafts, guided tissue replacement, vestibuloplasty etc...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27527527/expression-of-odontogenic-and-osteogenic-markers-in-dpscs-and-shed-a-review
#17
Hii Siew Ching, Norhayati Luddin, Ismail Ab Rahman, Kannan Thirumulu Ponnuraj
The odontogenic and osteogenic potential of dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous tooth (SHED) have been shown clearly by various in vitro and in vivo studies. The findings are promising and demonstrated that dental tissue engineering can give a new hope to the individuals suffering from tooth loss and dental diseases. The evaluation of odontogenic and osteogenic differentiation of DPSCs and SHED is commonly carried out by an illustration of the expression of varied related markers...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27515324/therapeutic-potential-of-endothelial-progenitor-cells-in-the-field-of-orthopaedics
#18
Yohei Kawakami, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Kunj G Patel, Garth N Walker, Masahiro Kurosaka, Ryosuke Kuroda
Inadequate blood supply frequently impedes the viability of tissue-engineered constructs in the initial phase after implantation, and can lead to improper cell integration or cell death. Vascularization using stem cells has continued to evolve as a potential solution to this problem. In this review, we summarize studies that utilize endothelial progenitor cells (EPCs) for musculoskeletal regeneration. This review will also highlight recent concepts for EPC identification in conjunction with the development of EPC biology research...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27412678/hospital-exemption-for-advanced-therapy-medicinal-products-issue-in-application-in-the-european-union-member-states
#19
Tatjana Ivaskiene, Mykolas Mauricas, Justinas Ivaska
Regulation (EC) 1394/2007 of the European Parliament and the Council on advanced therapy medicinal products and amending Directive 2001/83/EC and Regulation (EC) No 726/2004 allowed the use of non - authorized advanced therapy medicinal products under the certain circumstances. This socalled hospital exemption rule needs to be applied in the each Member State of the European Union individually and for this purpose Member States should provide national procedures and control measures. The aim of this article is to clear up the criteria for hospital exemption listed in Regulation (EC) 1394/2007 and to contrast the difference in implementing hospital exemption rule into national legal regimes on examples of the United Kingdom, Lithuania and Poland...
2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27412677/role-of-mesenchymal-stem-cells-in-dermal-repair-in-burns-and-diabetic-wounds
#20
Eric L Maranda, Luis Rodriguez-Menocal, Evangelos V Badiavas
In this review we explore stem cell function in wounds that are resistant to healing, such as burn injuries and diabetic wounds. Diabetic ulcers are of interest due to their remarkable resistance to heal; severe thermal burns are addressed due to critical need for effective therapies for the prevention shock and improvement in scarring. Cell-based therapy utilizing mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, are currently being investigated as a therapeutic avenue for both chronic diabetic ulcers and severe thermal burns...
2017: Current Stem Cell Research & Therapy
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