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Current Stem Cell Research & Therapy

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https://www.readbyqxmd.com/read/29895256/crispr-cas9-in-stem-cell-research-current-application-and-future-perspective
#1
Sathya Narayanan Patmanathan, Nareshwaran Gnanasegaran, Moon Nian Lim, Roslina Husaini, Kamal Shaik Fakiruddin, Zubaidah Zakaria
The clustered regularly interspaced short palindromic repeats-associated protein 9 or CRISPR/Cas9 system is one of the hottest topics discussed lately due to its robustness and effectiveness in genome editing. The technology has been widely used in life science research including microbial, plant, animal, and human cell studies. Combined with the pluripotency of stem cells, the technology represents a powerful tool to generate various cell types for disease modeling, drug screening, toxicology, and targeted therapies...
June 12, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29769009/mesenchymal-stem-cell-research-in-veterinary-medicine
#2
Mudasir Bashir Gugjoo, Amarpal, Vikash Chandra, Mohd Yaqoob Wani, Kuldeep Dhama, Gutulla Taru Sharma
BACKGROUND: The stem cells due to their unique characteristic features like self-renewal, multiplication, immuno-modulation and differentiation, are seen and hoped to bring new horizons in the field of biology, in general and medicine, in particular. OBJECTIVE: Among various stem cell types, currently mesenchymal stem cells (MSCs) are extensively studied in regenerative medicine owing to their readily available sources, easy harvesting and ability to differentiate both into mesodermal as well as non-mesodermal tissues with little associated ethical issues...
May 16, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29766824/adipose-derived-mesenchymal-stem-cells-in-the-treatment-of-obesity-a-systematic-review-of-longitudinal-studies-on-preclinical-evidence
#3
Fatima Saleh, Leila Itani, Simona Calugi, Riccardo Dalle Grave, Marwan El Ghoch
BACKGROUND: Obesity is an increasing global health problem, but its treatment is not yet optimal, especially in the long term. For this reason, preclinical studies have been conducted relating to a new therapeutic strategy for obesity based on adipose-derived mesenchymal stem cells (AD-MSCs). The aim of our systematic review is to summarize these findings deriving from the animal model in order to establish whether there is sufficient evidence to justify going forward to clinical studies...
May 15, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29756585/animal-models-used-for-testing-hydrogels-in-cartilage-regeneration
#4
Chuntie Zhu, Qiong Wu, Xu Zhang, Fubo Chen, Xiyang Liu, Qixiang Yang, Lei Zhu
Focal cartilage or osteochondral lesions can be painful and detrimental. Besides pain and limited function of joints, cartilage defect is considered as one of the leading extrinsic risk factors for osteoarthritis (OA). Thus, clinicians and scientists have paid great attention to regenerative therapeutic methods for the early treatment of cartilaginous defects. Regenerative medicine, showing great hope for regenerating cartilage tissue, rely on the combination of biodegradable scaffolds and specific biological cues, such as growth factors, adhesive factors and genetic materials...
May 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29756586/the-review-of-nanomaterials-inducing-the-differentiation-of-stem-cells-into-chondrocyte-phenotypes-in-cartilage-tissue-engineering
#5
Xueping Xie, Qi Zhang, Tengfei Zhou, Quanquan Ma, Liao JinFeng
Cartilage, as a nanostructured tissue, because of its awfully poor capacity for inherent regeneration and complete hierarchical structure, is severely difficult to regenerate after damages. Tissue engineering methods have provided great contribution for cartilage repair. Nanomaterials have special superiority in regulating stem cell behaviors due to their special mechanical and biological properties and biomimetic characteristics, therefore, they have been given great attention in tissue regeneration. Nanomaterials are divided into organic and inorganic nanomaterials...
May 11, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29745340/problems-in-stem-cell-therapy-for-cardiac-repair-and-tissue-engineering-approaches-based-on-graphene-and-its-derivatives
#6
Ayca Aslan, Adil Allahverdiyev, Melahat Bagirova, Emrah Abamor
BACKGROUND: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair...
May 9, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29732994/towards-standardized-stem-cell-therapy-in-type-2-diabetes-mellitus-a-systematic-review
#7
Jeanne Adiwinata Pawitan, Zheng Yang, Ying Nan Wu, Eng Hin Leed
OBJECTIVE: To compile and analyze the published studies on cell therapy for type 2 diabetes mellitus (T2DM) to obtain a better insight into management of T2DM that involved stem cell therapy. METHODS: We searched all published studies in Pubmed/Medline, and Cochrane library, using keywords: 'stem cell' AND 'therapy' AND 'diabetes type 2'. INCLUSION CRITERIA: original articles on the use of stem cells in humans with T2DM. EXCLUSION CRITERIA: articles in the non-English literature, studies on T2DM complications that did not assess both adverse events and any of the common diabetes study outcomes...
May 2, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29732993/endothelial-progenitor-cells-as-molecular-targets-in-vascular-senescence-and-repair
#8
Divya Rana, Saurabh Sharma
Endothelial progenitor cells are circulating blood cells derived from various sources like bone marrow, spleen, umbilical cord, liver, kidney and other sources that play a vital role in the regeneration of endothelial lining of blood vessels and wound repair. There are two types of EPCs, early EPCs and late EPCs. EPCs are believed to originate from hematopoietic stem cells and mesenchymal stem cells. The mobilization of progenitor cells from bone marrow to the peripheral circulation is highly regulated under both normal physiological conditions and stress...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29732992/current-status-of-stem-cell-therapies-in-tissue-repair-and-regeneration
#9
Tapan Kumar Giri, Amit Alexander, Mukta Agrawal, Swarnalata Saraf, Shailendra Saraf, Ajazuddin
Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapies in tissue repair and regeneration...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29714147/epithelial-in-vitro-differentiation-of-mesenchymal-stem-cells
#10
Alvaro Sierra-Sanchez, Alexandra Ordonez-Luque, Olga Espinosa-Ibanez, Antonio Ruiz-Garcia, Salvador Arias-Santiago
Mesenchymal stem cells or mesenchymal stromal cells (MSCs) are non-hematopoietic stromal cells that reside in and have been isolated from a variety of adult or fetal tissues such as adipose tissue, bone marrow and umbilical cord Wharton's jelly, among others. Because they are a heterogeneous population, International Society for Cellular Therapy has established 3 minimum criteria to characterize MSCs in vitro: i) adherence to plastic, ii) differentiation potential (osteogenic, chondrogenic and adipogenic lineages) and iii) expression of specific surface antigens (CD73+, CD90+, CD105+, CD34-, CD45-, CD11b-, CD14-, CD19-, CD79a-, HLA-DR-)...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29701160/non-pregnant-human-uterus-as-source-of-mesenchymal-stem-cells
#11
Noemi Eiro, Maria Fraile, Jose Schneider, Francisco Vizoso
Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfully in autologous or allogeneic transplantation, and all this in accordance with the applicable guidelines of good manufacturing practice. Thus, the identification and characterization of alternative sources of mesenchymal stem cells (MSCs) is of great importance...
April 26, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29697030/the-role-of-stem-cells-for-reconstructing-the-lower-urinary-tracts
#12
Niall Davis, Eoghan Cunnane, John Mulvihill, Mark Quinlan, Damien Bolton, Michael Walsh, Greg Jack
BACKGROUND: The urinary bladder and urethra comprise the lower urinary tracts. Pathological conditions that affect both structures necessitate reconstructive urological intervention with autologous tissue sources that cause neuromechanical and metabolic complications. Stem-cell therapies may offer an attractive alternative as they can replicate important host derived cellular functions such as mitosis, proliferation, differentiation and apoptosis. OBJECTIVE: To provide an overview on the application of stem cell therapies for regenerating the lower urinary tracts and to discuss factors that need to be addressed before stem-cells can be reliably introduced into clinical urological practice...
April 25, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29663898/electrospun-fibers-for-cartilage-tissue-regeneration
#13
Guo Li, Sirong Shi, Shiyu Lin, Tengfei Zhou, Xiaoru Shao, Qiao Huang, Bofeng Zhu, Xiaoxiao Cai
BACKGROUND: Due to its poor self-repair ability, the cartilage injury has been a great challenge in clinical work. OBJECTIVE: The conventional therapies for cartilage injury mostly form fibrocartilage with weaker strength and flexibility compared to natural cartilage. The development of tissue engineering technology provides a new approach for cartilage repair and regeneration. RESULTS: An appropriate scaffold is one of key factors in cartilage tissue engineering...
April 17, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29473525/oral-mucosal-stem-cells-human-immature-dental-pulp-stem-cells-and-hair-follicle-bulge-stem-cells-as-adult-stem-cells-able-to-correct-limbal-stem-cell-deficiency
#14
Nada Tarek Hassan, Neveen Ahmed AbdelAziz
Adult stem cells are somatic stem cells distributed all over the body. They represent a promising future for regenera-tive medicine because of their multiple advantages as they are widely available, accessible, easily stored and manipulated to a wide range of cells and with minimal invasive extraction. This review describes three examples of adult stem cells: oral mucosal epithelial stem cells, human immature dental pulp stem cells and hair follicle bulge stem cells that show an ability to correct limbal stem cell deficiency, their isolation and cultivation methods, feeder layers, carriers, markers expressed, successfulness to regenerate the ocular surface and mimic the corneal function in LSCD...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29303079/stem-cells-transplantation-in-the-treatment-of-patients-with-liver-failure
#15
Ya-Chao Tao, Meng-Lan Wang, En-Qiang Chen, Hong Tang
BACKGROUND: Liver failure is a life-threatening liver disease encompassing severe acute deterioration of liver function. Emergency liver transplantation is the only curative treatment for liver failure, but is restricted by the severe shortage of organ donors. Stem cell, including embroyonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells and hepatic progenitor cells, have capacity to proliferate and differentiate and could be used in a variety of liver diseases including hereditary liver diseases, cirrhosis and liver failure...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29285998/structure-function-evaluation-of-stem-cell-therapies-for-spinal-cord-injury
#16
Fuguo Zhang
BACKGROUND: Spinal cord injuries (SCI) are prevalent, devastating for quality and expectancy of life, and cause heavy economic burdens. Stem cell therapies hold promise in complete structural and functional restoration of SCI. OBJECTIVE: This review focuses on the methods currently used to evaluate the stem cell therapies for SCI. RESULTS: Various kinds of stem cells involving embryonic stem cells (ESCs), bone marrow stromal cells (BMSCs), neural stem cells (NSCs) and induced pluripotent stem cells (iPSCs) are extensively used in regenerative research of SCI...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29284397/stem-progenitor-cells-and-biodegradable-scaffolds-in-the-treatment-of-retinal-degenerative-diseases
#17
Yuyao Wang, Dandan Zhang, Bingqiao Shen, Yi Zhang, Ping Gu
BACKGROUND: Visual impairment caused by retinal degeneration is primarily attributed to the irreversible degradation of retinal neurons or the adjacent retinal pigment epithelium (RPE). No efficient clinical therapies to restore or improve visual ability are currently available. Cell therapy has been touted as a promising strategy to overcome this challenge. OBJECTIVE: This review aims to depict the effects and progresses of using stem/progenitor cells and biodegradable scaffolds in the treatment of retinal degenerative diseases, as well as discuss the challenges and opportunities of cell-based therapy for the future clinical application...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29034841/ppar-%C3%AE-and-wnt-regulate-the-differentiation-of-mscs-into-adipocytes-and-osteoblasts-respectively
#18
Yue Li, Daxiang Jin, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren
BACKGROUND: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown. OBJECTIVE: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC differentiation into adipocytes and osteoblasts. RESULTS: Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28969580/the-potential-for-synovium-derived-stem-cells-in-cartilage-repair
#19
Eva Johanna Kubosch, Gernot Lang, David Furst, David Kubosch, Kaywan Izadpanah, Bernd Rolauffs, Norbert P Sudkamp, Hagen Schmal
BACKGROUND: Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of large, isolated, full thickness cartilage defects. Several disadvantages such as the need for two surgical procedures or hypertrophic regenerative cartilage, underline the need for alternative cell sources...
February 23, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28914209/knee-ligament-injury-and-the-clinical-application-of-tissue-engineering-techniques-a-systematic-review
#20
Thomas C Riley, Reza Mafi, Pouya Mafi, Wasim S Khan
BACKGROUND: The incidence of knee ligament injury is increasing and represents a significant cost to healthcare providers. Current interventions include tissue grafts, suture repair and non-surgical management. These techniques have demonstrated good patient outcomes but have been associated graft rejection, infection, long term immobilization and reduced joint function. The limitations of traditional management strategies have prompted research into tissue engineering of knee ligaments...
February 23, 2018: Current Stem Cell Research & Therapy
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