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Current Stem Cell Research & Therapy

Hao Wen, Yuan He, Ke Zhang, Xiaobin Yang, Dingjun Hao, Baorong He
Pyrroloquinoline quinone(PQQ)is the third coenzyme found after the niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent properties of PQQ as an antioxidant and redox modulator in various systems,In recent years, the role of PQQ in the field of osteoporosis and neuro injury has become a research hot spot. This article mainly discusses the derivatives, distribution of PQQ, in vitro models of osteoporosis and neuro injury, and the research progress of its mechanism of action...
December 10, 2018: Current Stem Cell Research & Therapy
Xinxin Zhu, Bruno Péault, Guijun Yan, Haixiang Sun, Yali Hu, Lijun Ding
Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that bone marrow mesenchymal stem cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-derived stem cells, the association between BM-MSCs and endometrial stem cells, and progress in repairing endometrial injury...
December 5, 2018: Current Stem Cell Research & Therapy
Benjamin Mesure, Patrick Menu, Jagadeesh Kumar Venkatesan, Magali Cucchiarini, Émilie Velot
Musculoskeletal pathologies, especially those affecting bones and joints, remain a challenge for regenerative medicine. The main difficulties affecting bone tissue engineering are the size of the defects, the need for blood vessels and the synthesis of appropriate matrix elements in the engineered tissue. Indeed, the cartilage is an avascular tissue and consequently has limited regenerative abilities. Thanks to their self-renewal, plasticity and immunomodulatory properties, mesenchymal stem cells (MSCs) became a central player in tissue engineering, and have already been shown to be able to differentiate towards chondrogenic or osteogenic phenotypes...
December 5, 2018: Current Stem Cell Research & Therapy
Zhen Zhang, Hao Wen, Xiaobin Yang, Ke Zhang, Baorong He, Xinliang Zhang, Lingbo Kong
Bone homeostasis is strictly regulated by balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts.Disruption of the balance of activity between osteoblasts and osteoclasts leads to various metabolic bone diseases.Osteoclasts are cells of hematopoietic origin that they are large, multinucleated cells formed by the fusion of precursor cells of monocyte/macrophage lineage,they are unique cells that degrade the bone matrix. activation of transcription factors nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation and it plays the role of a master transcription regulator of osteoclast differentiation,meanwhile,NFATc1 could be employed to elicit anabolic effects on bone...
December 5, 2018: Current Stem Cell Research & Therapy
Alessandro Poggi, Maria Raffaella Zocchi
Mesenchymal stromal cells (MSC) are mesodermal elements characterized by the ability to differentiate into several types of cells present mainly in connective tissues. They play a key function in tissue homeostasis and repair. Furthermore, they exert a strong effect on both innate and adaptive immune response. The main current of thought considers MSC as strong inhibitors of the immune system. Indeed, the first description of MSC immunomodulation pointed out their inability to induce allo immune responses and their veto effects on mixed lymphocyte reactions...
December 4, 2018: Current Stem Cell Research & Therapy
Jian Zhu, Yitian Wang, Wei Yu, Kaishun Xia, Yuluan Huang, Junjie Wang, Bing Liu, Fangcai Li, Chengzhen Liang, Huimin Tao
BACKGROUND: Long suspected as transcriptional noise, recently recognized, long non-coding RNAs (lncRNAs) are emerging as an indicator, biomarker and therapy target in the physiologic and pathologic process. Mesenchymal stem cells and embryonic stem cells are important source for normal and therapeutic tissue repair. However, the mechanism of stem cell differentiation is not completed understood. Research on lncRNAs may provide novel insights into the mechanism of differentiation process of the stem cell which is important for the application of stem cell therapy...
November 27, 2018: Current Stem Cell Research & Therapy
Xinliang Zhang, Ke Zhang, Youhan Wang, Rui Ma
In humans, oxidative stress is thought to be involved in the development of Parkinson' s disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, depression. Myricitrin, a botanical flavone, is abundantly distributed in the root bark of Myrica cerifera, Myrica esculenta, Ampelopsis grossedentata, Nymphaea lotus, Chrysobalanus icaco, and other plants. Considering the abundance of its natural sources, myricitrin is relatively easy to extract and purify. Myricitrin reportedly possesses effective anti-oxidative, anti-inflammatory, and anti-nociceptive activities, and can protect a variety of cells from in vitro and in vivo injuries...
November 25, 2018: Current Stem Cell Research & Therapy
Farshad Zarei, Abolfazl Abbaszadeh
The human skin undergoes the complex process of aging which is prompted by the interplay of intrinsic mechanisms and extrinsic influences. Aging is unavoidable but can be somewhat delayed. Numerous approaches have been developed to slow down or improve on facial skin aging process as it is of interest to stake holders in the beauty and fashion world as well as to plastic surgeons. Adipose-derived stem cell [ADSC] and mesenchymal stem cell [MSC] as potential anti-ageing agents to some extent has provided a promising and effective alternative in managing skin and facial skin ageing...
November 12, 2018: Current Stem Cell Research & Therapy
Dilcele Silva Moreira Dziedzic, Bassam Felipe Mogharbel, Priscila Elias Ferreira, Ana Carolina Irioda, Katherine Athayde Teixeira de Carvalho
This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords "ADIPOSE", "CELLS", and "PERIODONTAL", with the Boolean operator "AND". A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose-derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers...
November 5, 2018: Current Stem Cell Research & Therapy
Nasim Kiaie, Rouhollah Mehdinavaz Aghdam, Seyed Hossein Ahmadi Tafti, Armita Mahdavi Gorabi
Angiogenesis has always been a concern in the field of tissue engineering. Poor vascularization of engineered constructs is a problem for clinical success of these structures. Among the various methods employed to induce angiogenesis, stem cells provide a promising tool for future. The present review aims to present the application of stem cells in the induction of angiogenesis. Additionally, it summarizes recent advancements in stem cell-mediated angiogenesis of different tissue engineering constructs.
November 5, 2018: Current Stem Cell Research & Therapy
Wei Zhou, Ming Qu, Yajie Lv, Jinyu Zhu
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease with multiple etiologies that more frequently occurs in middle-aged and young people. ONFH is the main cause of hip replacement in young patients. Since Professor Hernigou first reported the use of stem cells in the treatment of early stage ONFH, a large number of studies have demonstrated the potential of stem cells in the treatment of adult patients with ONFH. With the rise of interdisciplinary, stem cell therapy combined with platelet-rich plasma therapy, gene therapy or other methods are gradually attracted the attention of researchers...
October 25, 2018: Current Stem Cell Research & Therapy
Elham Hoveizi, Shima Tavakol, Sadegh Shirian, Khadije Sanamiri
Diabetes mellitus (DM) is an autoimmune disease causing progressive destruction of pancreatic β cells, ultimately resulting in loss of insulin secretion producing which leads to hyperglycemia. Replacement of pancreatic β cells would represent an ideal treatment for DM that could overcome the therapeutic hurdles. Principals of cell therapy for diabetes are reviewed in the first part of this article. Moreover, the usability of tissue engineering (TE) as a new approach for DM treatment is discussed in the second part...
October 18, 2018: Current Stem Cell Research & Therapy
Yingjuan Li, Guangchun Dai, Liu Shi, Yucheng Lin, Minhao Chen, Gang Li, Yunfeng Rui
Ageing is a key dangerous factor for the occurrence and severity of tendon injury, but the exact cognition of the relationship is elusive at present. More previous studies suggest age-related changes occur at tendon mechanical properties, structure and composition, but the pathological alternations may be overlooked, which might be causes for the structure and function variations, and even speed up the progress of age-related disorders. Recently, the presence of tendon stem/progenitor cells (TSPCs) would provide new insights for pathogenesis of tendon ageing...
October 17, 2018: Current Stem Cell Research & Therapy
Payam Zarrintaj, Farnaz Mostafapoor, Peiman Brouki Milan, Mohammad Reza Saeb
It is a near-to-impossible not to accept that cancer takes position as the main cause of global burden of disease, for it is hard to ignore the outnumbered people dying from cancer. Looking at the statistics proves that progress in cancer therapy is always beyond cancer in a race of pessimism about the future; for various kinds of cancers yearly cause death in the world, whereas the conventional and even modern therapies often exhibit lack of reliability in treatment of cancer. In principal, various reasons are identified for cancer resistance and recurrence...
October 2, 2018: Current Stem Cell Research & Therapy
Junaid Khan, Amit Alexander, Mukta Agrawal, Ajazuddin, Sunil Kumar Dubey, Sabahuddin Siddique, Swarnlata Saraf, Shailendra Saraf
Diabetes and its complications are a significant health concern throughout the globe. There are physiological differences in the mechanism of type-I and type-II diabetes and the conventional drug therapy as well as insulin administration seem insufficient to address the problem at large successfully. Hypoglycemic swings, frequent dose adjustments and resistance to the drug are major problems associated with drug therapy. Cellular approaches through stem cell based therapeutic interventions offer a promising solution to the problem...
October 2, 2018: Current Stem Cell Research & Therapy
Mukta Agrawal, Amit Alexander, Junaid Khan, Tapan Kumar Giri, Sabahuddin Siddique, Sunil Kumar Dubey, Ajazuddin, Ravish J Patel, Umesh Gupta, Swarnlata Saraf, Shailendra Saraf
The unique self-renewal and differentiation ability of stem cells drag the attention of many scientists and researchers towards the clinical application of stem cells. Stem cells are basically the normal living cells of multicellular organisms with some special ability to proliferate and transform into any kind of the body cells with their characteristic feature. Talking about human stem cells, it is originated from various sources like embryonic stem cells, somatic stem cells, hematopoietic stem cells, bone marrow stem cells, neural stem cells etc...
October 2, 2018: Current Stem Cell Research & Therapy
Gabriele D Bigoni-Ordóñez, Daniel Czarnowski, Tyler Parsons, Gerard J Madlambayan, Luis G Villa-Diaz
Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment...
October 2, 2018: Current Stem Cell Research & Therapy
Asrin Babahajian, Arash Sarveazad, Fereshteh Golab, Gelareh Vahabzadeh, Akram Alizadeh, Homa Rasoolijazi, Naser Amini, Maedeh Entezari, Mansoureh Soleimani, Majid Katebi
INTRODUCTION: One of the serious complications of stroke is memory impairment, which is considered as one of the complications of reperfusion of tissue. The present study was designed to compare the effect of administration of Trolox, carnosic acid and Human Chorionic Gonadotropin (HCG) immediately after reperfusion of the stroke tissue on the memory and hippocampal histology. METHOD: Ischemia reperfusion model (IRI) was created by bilateral occlusion of the common carotid artery for 15 minutes and the first dose was administered immediately after reperfusion...
September 17, 2018: Current Stem Cell Research & Therapy
Aravinth P Jawahar, Siddharth Narayanan, Gopalakrishnan Loganathan, Jithu Pradeep, Gary C Vitale, Christopher M. Jones, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipulated to form insulin-producing cells...
September 17, 2018: Current Stem Cell Research & Therapy
Kaishun Xia, Zhe Gong, Jian Zhu, Wei Yu, Yitian Wang, Junjie Wang, Ankai Xu, Xiaopeng Zhou, Huimin Tao, Fangcai Li, Chengzhen Liang
Low back pain (LBP) is one of the world's most common musculoskeletal diseases, and is frequently associated with intervertebral disc degeneration (IDD). While the main cause of IDD is commonly attributed to a reduced number of nucleus pulposus (NP) cells, current treatment strategies (both surgical and more conservative) fail to replenish NP cells or reverse the pathology. Cell replacement therapies are an attractive alternative for treating IDD. However, injecting intervertebral disc (IVD) cells, chondrocytes, or mesenchymal stem cells into various animal models of IDD indicate that transplanted cells generally fail to survive and engraft into the avascular IVD niche...
September 17, 2018: Current Stem Cell Research & Therapy
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