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Clinical Journal of the American Society of Nephrology: CJASN

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https://www.readbyqxmd.com/read/30217899/renal-fellow-network-past-and-future
#1
EDITORIAL
Samira Farouk, Matthew A Sparks
No abstract text is available yet for this article.
September 14, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30213782/perfluorinated-chemicals-as-emerging-environmental-threats-to-kidney-health-a-scoping-review
#2
John W Stanifer, Heather M Stapleton, Tomokazu Souma, Ashley Wittmer, Xinlu Zhao, L Ebony Boulware
BACKGROUND AND OBJECTIVES: Per- and polyfluoroalkyl substances (PFASs) are a large group of manufactured nonbiodegradable compounds. Despite increasing awareness as global pollutants, the impact of PFAS exposure on human health is not well understood, and there are growing concerns for adverse effects on kidney function. Therefore, we conducted a scoping review to summarize and identify gaps in the understanding between PFAS exposure and kidney health. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We systematically searched PubMed, EMBASE, EBSCO Global Health, World Health Organization Global Index, and Web of Science for studies published from 1990 to 2018...
September 13, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30201730/the-patient-receiving-automated-peritoneal-dialysis-with-volume-overload
#3
Emilie Trinh, Jeffrey Perl
No abstract text is available yet for this article.
September 10, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30181129/urea-for-the-treatment-of-hyponatremia
#4
Helbert Rondon-Berrios, Srijan Tandukar, Maria K Mor, Evan C Ray, Filitsa H Bender, Thomas R Kleyman, Steven D Weisbord
BACKGROUND AND OBJECTIVES: Current therapies for hyponatremia have variable effectiveness and tolerability, and in certain instances, they are very expensive. We examined the effectiveness, safety, and tolerability of urea for the treatment of inpatient hyponatremia. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We identified all patients hospitalized at the University of Pittsburgh Medical Center between July 2016 and August 2017 with hyponatremia (plasma sodium <135 mEq/L) who received urea, including a subgroup of patients who received urea as the sole drug therapy for hyponatremia (urea-only treated)...
September 4, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30171050/biocompatible-solutions-and-long-term-changes-in-peritoneal-solute-transport
#5
Emma H Elphick, Lucy Teece, James A Chess, Jun-Young Do, Yong-Lim Kim, H Bahl Lee, Sara N Davison, Nicholas Topley, Simon J Davies, Mark Lambie
BACKGROUND AND OBJECTIVES: The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because biocompatible solutions were developed to mitigate these effects, we examined the association with their use and longitudinal peritoneal solute transport rate. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We analyzed subjects from the multinational prospective Global Fluid Study with three or more peritoneal solute transport rate measurements >2 months from the start of peritoneal dialysis...
August 31, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30171049/pd-solutions-and-peritoneal-health
#6
EDITORIAL
Yeoungjee Cho, David W Johnson
No abstract text is available yet for this article.
August 31, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30143529/young-kidney-professionals-perspectives-and-attitudes-about-consuming-scientific-information-a-focus-group-study
#7
Allison Tong, Deidra C Crews, Jane O Schell, Ian H de Boer, Michel Chonchol, Rajnish Mehrotra
The digital era has seen rapid changes in how information is consumed. Traditional dissemination of scholarly work through biomedical journals may not be optimally tailored to the preferences of younger clinicians and researchers. We aimed to describe the perspectives of young clinicians and researchers in kidney disease on consuming scientific information. Three focus groups were conducted during the 2017 American Society of Nephrology Kidney Week with a total of 29 nephrologists and researchers (ages 40 years old and younger) purposively sampled through our networks and the American Society of Nephrology registration database...
August 24, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30135171/impact-of-navigators-on-first-visit-to-a-transplant-center-waitlisting-and-kidney-transplantation-a-randomized-controlled-trial
#8
Catherine M Sullivan, Kitty V Barnswell, Kate Greenway, Cindy M Kamps, Derrick Wilson, Jeffrey M Albert, Jacqueline Dolata, Anne Huml, Julie A Pencak, John T Ducker, Roberto Gedaly, Christopher M Jones, Todd Pesavento, Ashwini R Sehgal
BACKGROUND AND OBJECTIVES: Many patients with ESKD face barriers in completing the steps required to obtain a transplant. These eight sequential steps are medical suitability, interest in transplant, referral to a transplant center, first visit to center, transplant workup, successful candidate, waiting list or identify living donor, and receive transplant. This study sought to determine the effect of navigators on helping patients complete these steps. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study was a cluster randomized, controlled trial involving 40 hemodialysis facilities and four transplant centers in Ohio, Kentucky, and Indiana from January 1, 2014 to December 31, 2016...
August 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30089664/peripheral-blood-b-cell-depletion-after-rituximab-and-complete-response-in-lupus-nephritis
#9
Liliana Michelle Gomez Mendez, Matthew D Cascino, Jay Garg, Tamiko R Katsumoto, Paul Brakeman, Maria Dall'Era, Richard John Looney, Brad Rovin, Leonard Dragone, Paul Brunetta
BACKGROUND AND OBJECTIVES: Incomplete peripheral blood B cell depletion after rituximab in lupus nephritis might correlate with inability to reduce tubulointerstitial lymphoid aggregates in the kidney, which together could be responsible for inadequate response to treatment. We utilized data from the Lupus Nephritis Assessment with Rituximab (LUNAR) study to characterize the variability of peripheral blood B cell depletion after rituximab and assess its association with complete response in patients with lupus nephritis...
August 8, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30087102/persistent-bias-a-threat-to-diversity-among-health-care-leaders
#10
Deidra C Crews, Donald Everett Wesson
No abstract text is available yet for this article.
August 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30082337/biosimilars-emerging-role-in-nephrology
#11
Jay B Wish
The Food and Drug Administration (FDA) defines a "biosimilar" agent as a biologic that is highly similar to the reference or originator biologic product notwithstanding minor differences in clinically inactive components with no clinically meaningful differences in terms of the safety, purity, and potency. The advantage of biosimilars is that they are usually about 15%-30% less expensive than the reference product, which results in system-wide cost savings and increased patient access. Because biologic drugs are produced by living organisms, they are by nature heterogeneous and identical copies cannot be made, unlike generic versions of small-molecule drugs...
August 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30082336/helping-more-patients-receive-a-living-donor-kidney-transplant
#12
Amit X Garg
The best treatment option for many patients with kidney failure is a kidney transplant from a living donor. Countries that successfully increase their rate of living kidney donation will decrease their reliance on dialysis, the most expensive and high-risk form of kidney replacement therapy. Outlined here are some barriers that prevent some patients from pursuing living kidney donation and current knowledge on some potential solutions to these barriers. Also described are strategies to promote living kidney donation in a defensible system of practice...
August 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30065068/hepatitis-c-virus-infection-in-eskd-patients
#13
Marco Ladino, David Roth
No abstract text is available yet for this article.
July 31, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30065067/insights-into-the-role-of-mucosal-immunity-in-iga-nephropathy
#14
Yue-Miao Zhang, Hong Zhang
No abstract text is available yet for this article.
July 31, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30054352/uromodulin-and-nephron-mass
#15
LETTER
Edward Pivin, Belen Ponte, Sophie de Seigneux, Daniel Ackermann, Idris Guessous, Georg Ehret, Antoinette Pechère-Bertschi, Eric Olinger, Markus Mohaupt, Bruno Vogt, Pierre-Yves Martin, Michel Burnier, Murielle Bochud, Olivier Devuyst, Menno Pruijm
No abstract text is available yet for this article.
July 27, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30049849/recent-advances-in-the-management-of-autosomal-dominant-polycystic-kidney-disease
#16
REVIEW
Fouad T Chebib, Vicente E Torres
Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic cause of ESKD, is characterized by relentless development of kidney cysts, hypertension, and destruction of the kidney parenchyma. Over the past few years, major advancements in diagnosing, prognosticating, and understanding the pathogenesis and natural course of the disease have been made. Currently, no kidney disease is more suitable for nephron-protective strategies. Early nephrology referral and implementation of these strategies may have a substantial effect...
July 26, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30045913/minding-the-missing-link-the-effect-of-donor-recipient-pairing-on-kidney-transplant-outcomes
#17
Amanda J Vinson, Karthik K Tennankore
No abstract text is available yet for this article.
July 25, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29954825/how-i-treat-protein-energy-wasting-in-hemodialysis-patients
#18
Menaka Sarav, Csaba Pal Kovesdy
No abstract text is available yet for this article.
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30194227/two-year-observational-study-of-bloodstream-infection-rates-in-hemodialysis-facility-patients-with-and-without-catheters
#19
Robert S Brown, Kristin Brickel, Roger B Davis
BACKGROUND AND OBJECTIVES: Bloodstream infection rates of patients on hemodialysis with catheters are greater than with other vascular accesses and are an important quality measure. Our goal was to compare relative bloodstream infection rates of patients with and without catheters as a quality parameter among the facilities providing hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used CROWNWeb and National Healthcare Safety Network data from all 179 Medicare facilities providing adult outpatient hemodialysis in New England for >6 months throughout 2015-2016 (mean, 12,693 patients per month)...
September 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30154221/association-of-urinary-biomarkers-of-kidney-injury-with-estimated-gfr-decline-in-hiv-infected-individuals-following-tenofovir-disoproxil-fumarate-initiation
#20
Simon B Ascher, Rebecca Scherzer, Michelle M Estrella, William R Zhang, Anthony N Muiru, Vasantha Jotwani, Carl Grunfeld, Chirag R Parikh, Deborah Gustafson, Mary Young, Anjali Sharma, Mardge H Cohen, Derek K Ng, Frank J Palella, Mallory D Witt, Ken Ho, Michael G Shlipak
BACKGROUND AND OBJECTIVES: Tenofovir disoproxil fumarate (tenofovir) is associated with elevated concentrations of biomarkers of kidney damage and dysfunction in individuals with HIV. The relationship of these kidney biomarkers with longitudinal kidney function decline is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated associations of 14 urinary biomarkers of kidney injury with changes in eGFR among 198 men and women with HIV who initiated tenofovir between 2009 and 2015 in the Multicenter AIDS Cohort Study and Women's Interagency HIV Study...
September 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
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