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Clinical Journal of the American Society of Nephrology: CJASN

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https://www.readbyqxmd.com/read/30018051/rebuilding-the-pipeline-of-investigators-in-nephrology-research-in-the-united-states
#1
Jenna M Norton, Christian J Ketchum, Tracy L Rankin, Robert A Star
No abstract text is available yet for this article.
July 17, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30018050/organ-donation-and-the-principles-of-gift-law
#2
Alexandra K Glazier
No abstract text is available yet for this article.
July 17, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30018049/urgent-start-peritoneal-dialysis-defining-what-it-is-and-why-it-matters
#3
Peter G Blake, Arsh K Jain
No abstract text is available yet for this article.
July 17, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30012630/abo-incompatible-kidney-transplant-outcomes-a-meta-analysis
#4
Annelies E de Weerd, Michiel G H Betjes
BACKGROUND AND OBJECTIVES: ABO blood group-incompatible kidney transplantation is considered a safe procedure, with noninferior outcomes in large cohort studies. Its contribution to living kidney transplantation programs is substantial and growing. Outcomes compared with center-matched ABO blood group-compatible control patients have not been ascertained. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Comprehensive searches were conducted in Embase, Medline, Cochrane, Web-of-Science, and Google Scholar...
July 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30012629/-col4a3-gene-variants-and-diabetic-kidney-disease-in-mody
#5
Yiting Wang, Junlin Zhang, Yingwang Zhao, Shanshan Wang, Jie Zhang, Qianqian Han, Rui Zhang, Ruikun Guo, Hanyu Li, Li Li, Tingli Wang, Xi Tang, Changzheng He, Geer Teng, Weiyue Gu, Fang Liu
BACKGROUND AND OBJECTIVES: Despite advances in identifying genetic factors of diabetic kidney disease (DKD), much of the heritability remains unexplained. Nine maturity-onset diabetes in young (MODY) probands with kidney biopsy-proven DKD were selected and included in this study. The probands had more severe DKD compared with their parents with MODY, with overt proteinuria or rapid progression to ESKD. We aimed to explore the contribution of the variants in susceptibility genes of DKD to the severity of kidney phenotype between the probands and their parents...
July 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30012628/genetic-contribution-to-risk-for-diabetic-kidney-disease
#6
EDITORIAL
Stephen S Rich
No abstract text is available yet for this article.
July 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30012627/expand-the-pool-of-living-donors-for-kidney-transplantation
#7
EDITORIAL
Jayme E Locke
No abstract text is available yet for this article.
July 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30006343/circumstances-of-death-among-undocumented-immigrants-who-rely-on-emergency-only-hemodialysis
#8
LETTER
Lilia Cervantes, Ann O'Hare, Michel Chonchol, Madelyne Hull, Janice Van Bockern, Mandy Thompson, Jeff Zoucha
No abstract text is available yet for this article.
July 13, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30002224/risks-and-benefits-of-direct-oral-anticoagulants-across-the-spectrum-of-gfr-among-incident-and-prevalent-patients-with-atrial-fibrillation
#9
Jung-Im Shin, Alex Secora, G Caleb Alexander, Lesley A Inker, Josef Coresh, Alex R Chang, Morgan E Grams
BACKGROUND AND OBJECTIVES: All randomized trials of direct oral anticoagulants in atrial fibrillation excluded patients with severe kidney disease. The safety and effectiveness of direct oral anticoagulants across the range of eGFR in real-world settings is unknown. Our objective is to quantify the risk of bleeding and benefit of ischemic stroke prevention for direct oral anticoagulants compared with warfarin in patients with atrial fibrillation with and without CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We created a propensity score-matched cohort of 3206 patients with atrial fibrillation and direct oral anticoagulant use and 3206 patients with atrial fibrillation using warfarin from October of 2010 to February of 2017 in an electronic health record (Geisinger Health System)...
July 12, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29976600/variations-in-24-hour-bp-profiles-in-cohorts-of-patients-with-kidney-disease-around-the-world-the-i-dare-study
#10
Paul E Drawz, Roland Brown, Luca De Nicola, Naohiko Fujii, Francis B Gabbai, Jennifer Gassman, Jiang He, Satoshi Iimuro, James Lash, Roberto Minutolo, Robert A Phillips, Kyle Rudser, Luis Ruilope, Susan Steigerwalt, Raymond R Townsend, Dawei Xie, Mahboob Rahman
BACKGROUND AND OBJECTIVES: Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC)...
July 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29954826/emotional-impact-of-illness-and-care-on-patients-with-advanced-kidney-disease
#11
Ann M O'Hare, Claire Richards, Jackie Szarka, Lynne V McFarland, Whitney Showalter, Elizabeth K Vig, Rebecca L Sudore, Susan T Crowley, Ranak Trivedi, Janelle S Taylor
BACKGROUND AND OBJECTIVES: The highly specialized and technologically focused approach to care inherent to many health systems can adversely affect patients' emotional experiences of illness, while also obscuring these effects from the clinician's view. We describe what we learned from patients with advanced kidney disease about the emotional impact of illness and care. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: As part of an ongoing study on advance care planning, we conducted semistructured interviews at the VA Puget Sound Healthcare System in Seattle, Washington, with 27 patients with advanced kidney disease between April of 2014 and May of 2016...
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29954825/how-i-treat-protein-energy-wasting-in-hemodialysis-patients
#12
Menaka Sarav, Csaba Pal Kovesdy
No abstract text is available yet for this article.
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29954824/12-tips-to-nephrology-teams-supporting-patients-with-advanced-kidney-disease-an-advocate-s-dozen
#13
EDITORIAL
Edward V Hickey
No abstract text is available yet for this article.
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29934432/clinical-pharmacokinetics-in-kidney-disease-fundamental-principles
#14
Tom N Lea-Henry, Jane E Carland, Sophie L Stocker, Jacob Sevastos, Darren M Roberts
Kidney disease is an increasingly common comorbidity that alters the pharmacokinetics of many drugs. Prescribing to patients with kidney disease requires knowledge about the drug, the extent of the patient's altered physiology, and pharmacokinetic principles that influence the design of dosing regimens. There are multiple physiologic effects of impaired kidney function, and the extent to which they occur in an individual at any given time can be difficult to define. Although some guidelines are available for dosing in kidney disease, they may be on the basis of limited data or not widely applicable, and therefore, an understanding of pharmacokinetic principles and how to apply them is important to the practicing clinician...
June 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29934431/metabolic-changes-with-base-loading-in-ckd
#15
LETTER
Julia J Scialla, Landon Brown, Susan Gurley, David L Corcoran, James R Bain, Michael J Muehlbauer, Sara K O'Neal, Thomas M O'Connell, Myles Wolf, Michal L Melamed, Thomas H Hostetter, Matthew K Abramowitz
No abstract text is available yet for this article.
June 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29929999/association-between-medicaid-expansion-under-the-affordable-care-act-and-preemptive-listings-for-kidney-transplantation
#16
Meera N Harhay, Ryan M McKenna, Suzanne M Boyle, Karthik Ranganna, Lissa Levin Mizrahi, Stephen Guy, Gregory E Malat, Gary Xiao, David J Reich, Michael O Harhay
BACKGROUND AND OBJECTIVES: Before 2014, low-income individuals in the United States with non-dialysis-dependent CKD had fewer options to attain health insurance, limiting their opportunities to be preemptively wait-listed for kidney transplantation. We examined whether expanding Medicaid under the Affordable Care Act was associated with differences in the number of individuals who were pre-emptively wait-listed with Medicaid coverage. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the United Network of Organ Sharing database, we performed a retrospective observational study of adults (ageā‰„18 years) listed for kidney transplantation before dialysis dependence between January 1, 2011-December 31, 2013 (pre-Medicaid expansion) and January 1, 2014-December 31, 2016 (post-Medicaid expansion)...
June 21, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29929998/the-affordable-care-act-kidney-transplant-access-and-kidney-disease-care-in-the-united-states
#17
EDITORIAL
Nitender Goyal, Daniel E Weiner
No abstract text is available yet for this article.
June 21, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29921736/twenty-four-hour-urine-phosphorus-as-a-biomarker-of-dietary-phosphorus-intake-and-absorption-in-ckd-a-secondary-analysis-from-a-controlled-diet-balance-study
#18
Elizabeth R Stremke, Linda D McCabe, George P McCabe, Berdine R Martin, Sharon M Moe, Connie M Weaver, Munro Peacock, Kathleen M Hill Gallant
BACKGROUND AND OBJECTIVES: Twenty-four-hour urine phosphorus is commonly used as a surrogate measure for phosphorus intake and absorption in research studies, but its reliability and accuracy are unproven in health or CKD. This secondary analysis sought to determine the reliability and accuracy of 24-hour urine phosphorus as a biomarker of phosphorus intake and absorption in moderate CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Eight patients with stage 3-4 CKD participated in 2-week balance studies with tightly controlled phosphorus and calcium intakes...
June 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29921734/intravenous-epoetin-alfa-epbx-versus-epoetin-alfa-for-treatment-of-anemia-in-end-stage-kidney-disease
#19
Steven Fishbane, Bhupinder Singh, Seema Kumbhat, Wayne A Wisemandle, Nancy E Martin
BACKGROUND AND OBJECTIVES: This study was conducted to compare the safety and efficacy of intravenous epoetin alfa-epbx, an epoetin alfa biosimilar, to epoetin alfa in patients on hemodialysis with ESKD and anemia. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this 24-week, multicenter, double-blind comparative efficacy and safety study, 612 patients on hemodialysis with ESKD and anemia who had stable hemoglobin and were receiving stable doses of intravenous epoetin alfa were randomized (1:1) to intravenous epoetin alfa or epoetin alfa-epbx...
June 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29915131/medication-safety-principles-and-practice-in-ckd
#20
Chanel F Whittaker, Margaret A Miklich, Roshni S Patel, Jeffrey C Fink
Ensuring patient safety is a priority of medical care because iatrogenic injury has been a primary concern. Medications are an important source of medical errors, and kidney disease is a thoroughfare of factors threatening safe administration of medicines. Principal among these is reduced kidney function because almost half of all medications used are eliminated via the kidney. Additionally, kidney patients often suffer from multimorbidity, including diabetes, hypertension, and heart failure, with a range of prescribers who often do not coordinate treatments...
June 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
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