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Current Drug Safety

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https://www.readbyqxmd.com/read/29745339/musculoskeletal-and-rheumatic-diseases-induced-by-immune-checkpoint-inhibitors-a-review-of-the-literature
#1
Devis Benfaremo, Lucia Manfredi, Michele Maria Luchetti, Armando Gabrielli
BACKGROUND: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated to a number of immune-related adverse events (AEs), including musculoskeletal and rheumatic disease. METHODS: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs induced by immune checkpoint inhibitors. RESULTS: Several musculoskeletal and rheumatic AEs associated with immune checkpoint inhibitors treatment are reported in literature...
May 8, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29745338/hyponatraemia-associated-with-tramadol-use-a-case-report
#2
Tuck Y Yong, Kareeann S.F. Khow
Hyponatraemia is frequently encountered in clinical practice and common among hospitalized patients. Tramadol is a commonly prescribed analgesia with few adverse effects. However, on rare occasions, tramadol has been found to be associated with hyponatraemia. In two patients described in this report, tramadol use was associated with symptomatic hyponatraemia which required hospitalization. Hyponatraemia were corrected after discontinuation of tramadol. A small number of patients with tramadol-associated hyponatraemia have been reported in the English-language medical literature...
May 8, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29623819/register-based-ecologic-evaluation-of-safety-signals-related-to-pneumococcal-conjugate-vaccine-in-children
#3
Miia Artama, Hanna Rinta-Kokko, Hanna Nohynek, Jukka Jokinen, Arto Palmu
BACKGROUND: In clinical trials of Pneumococcal Conjugate Vaccines (PCV), some adverse events have been reported more frequently in the PCV vaccinated. Ten-valent PCV (PCV10) was introduced into the Finnish National Vaccination Programme (NVP) in September 2010. OBJECTIVES: We conducted an ecologic register-based study to investigate further the reported adverse events after PCV. METHODS: This study included data obtained from the Finnish nationwide, population-based registers...
April 6, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29607784/sertraline-induced-acute-eosinophilic-pneumonia
#4
Mayssan Muftah, Rama Nassri, Ammar Nassri, Paul Harford
Acute Eosinophilic Pneumonia (AEP) is a rare, potentially fatal disease often characterized by a short febrile illness, hypoxemic respiratory failure, diffuse pulmonary opacities and evidence of pulmonary eosinophilia. AEP can be idiopathic, but has documented associations with multiple drugs. We present the first case highlighting Sertraline specifically as a cause of drug-induced AEP in the English literature.
April 2, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29607783/teratogenic-effects-of-third-generation-antiepileptic-drug-pregabalin-an-in-vivo-study
#5
K P Singh, Kiran Gupta
BACKGROUND: In the recent past, many third-generation antiepileptic drugs (AEDs) including Pregabalin (PGB) were launched for treatment of diverse forms of epilepsy with better efficacy and safety profile than first-and-second-generation AEDs, but their teratogenic safety has not been established so far. OBJECTIVE: The present study has been undertaken to evaluate the reproductive and teratogenic potential (external and skeletal) of a novel and third generation AED, PGB in pregnant albino rats...
April 2, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29564987/evaluation-of-inappropriate-medication-use-and-compliance-in-elderly-people
#6
Fikriye Yilmaz, Meric Yavuz Colak
OBJECTIVE: The aim of this study is to evaluate the potentially inappropriate medication use and medication compliance in elderly patients buying prescribed drugs from a pharmacy in Ankara. METHOD: In this cross-sectional field study, 200 elderly people who bought prescribed drug from a pharmacy in the hospital area in Ankara in April 2016 were chosen as random sample. A questionnaire consisting of questions related to socio-demographic characteristics, health status, drug use of elderly and Morisky Green Levine Medication Adherence Scale (MGLS) was used to collect data...
March 21, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29564988/detection-of-the-incidence-of-infections-and-acute-biochemical-changes-in-diffuses-large-b-cell-lymphoma-patients-treated-with-cyclophosphamide-doxorubicin-vincristine-and-prednisone-chop-with-and-without-rituximab
#7
Kashif Ali, Ali Akbar Sial, Mirza Tasawer Baig, Saqib Hussain Ansari, Syed Omair Adil, Tahir Sultan Shamsi
AIM AND OBJECTIVES: Acute biochemical changes, hepatotoxicity, nephrotoxicity and frequency of infections are common in diffuse large B-cell Lymphoma patients undergoing Cyclophosphamide, hydroxyrubicin, Oncovin (Vincristine) Prednisolone (CHOP) and Rituximab plus CHOP chemo cycles. Eventually, it leads to prolong hospital stay and suspending the next chemotherapy cycles. Changes in biochemical profile and immunosuppressant effects correlated with dose intensity ratio, the findings of this study will be helpful in choices for the physician to discontinue therapy or delaying treatment...
March 20, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29532759/amlodipine-150-mg-poisoning-a-case-study
#8
Prasan Kumar Panda, Annu Raj, Shiv Shankar Singh
Treatments of patient with amlodipine (a calcium channel blocker, CCB) overdose/poisoning remain challenging and death is certain if not intervened timely. Furthermore, for a society, the availability and common use of this drug make more vulnerable, especially by children, towards an accidental/suicidal poisoning. Here we describe an adolescent school girl who took 150 mg of amlodipine and was admitted in our hospital approximately 4 hours after ingestion with suicidal intention. She developed circulatory failure and tachypnea...
March 13, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29506464/a-rare-case-report-of-toxic-epidermal-necrolysis-due-to-ofloxacin
#9
Jhanvi J Vaghela, Vivek N Nimbark, Bhavesh C Chavda, Hita H Mehta, Bhargav M Purohit
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet uncleared. A 45-year-old male patient by chance on re-exposure to Ofloxacin developed severe cutaneous adverse drug reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN were lead him to death. In developing country where antibiotics especially fluoroquinolones widely prescribed, a physician should be now vigilant for such kind of SCADRs because of increasing numbers of such kind of reports...
March 2, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29485007/pinpoint-localized-odynophagia-plo-as-a-specific-symptom-of-pill-induced-oesophagitis-pio-in-the-evaluation-of-acute-retrosternal-chest-pain
#10
Dhruvkumar Patel, Mukundkumar V Patel, Sanjay L Rajput, Kamal Sharma
INTRODUCTION: 36 out of 100 cases of retrosternal chest pains are due to oesophageal pathologies and pill-induced oesophagitis(PIO) is one of them. PIO can present as retrosternal chest pain associated with various gastrointestinal (GI) symptoms and require a high index of suspicion. PIO is a clinical diagnosis; and oesophagogastroscopy is required for confirmation of the diagnosis, to find out complications of PIO and to rule out other oesophageal disorders. Our aims of the present study were to study clinical profile, risk factors and endoscopic features of PIO...
February 26, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29485005/vaping-versus-smoking-a-quest-for-efficacy-and-safety-of-e-cigarette
#11
Harmeet Singh Rehan, Jahnavi Maini, A Ps Hungin
BACKGROUND: Electronic cigarettes (ECIGs) are devices with a heating element which produces aerosol for inhalation. They have been propagated as a healthier alternative to tobacco smoking and a potential device for smoking cessation, despite non-documentation of their long-term adverse health effects. OBJECTIVES: With the glorification of ECIG, its use has increased even among non-tobacco users. This makes it critical to understand and discuss a true picture about safety and utility of ECIGs by reviewing the literature...
February 26, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29485006/risks-associated-with-sglt2-inhibitors-an-overview
#12
Mahakpreet Singh, Anoop Kumar
Sodium glucose co-transport 2 inhibitors (SGLT2-i) are the new class of anti-diabetic medications which are the recently approved (2013) by FDA for the treatment of diabetes. These inhibitors block the SGLT2 protein which involved in glucose reabsorption from proximal renal tubule which results in increased glucose excretion and lower blood glucose levels. These inhibitors exert favourable effects beyond glucose control such as consistent body weight, blood pressure, and serum uric acid reductions. Canagliflozin, Dapagliflozin, and Empagliflozin belong to the class of SGLT2 inhibitors...
February 25, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29468979/potentiation-of-warfarin-associated-with-salsalate-therapy-resulting-in-bleeding
#13
Joseph P Rindone, Chadwick K Mellen
BACKGROUND: Salsalate may offer many advantages over other non-steroidal anti-inflammatory agents in patients taking warfarin, however a drug-drug interaction may occur which has not been reported in the medical literature or by the manufacturer of salsalate. OBJECTIVE: To report a case of warfarin potentiation associated with salsalate treatment, which resulted in bleeding. METHODS: Clinical review of the course of a patient, who was stable on warfarin when salsalate therapy was added for chronic pain...
February 19, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29437014/drug-induced-epistaxis-an-often-neglected-adverse-effect
#14
Sara Meirinho, Ricardo Relvas, Gilberto Alves
BACKGROUND: Epistaxis is an active nose bleeding with a population occurrence of approximately 60%. Although epistaxis is a common clinical complaint, the majority of the cases are benign and caused by local induced factors (e.g., trauma and local inflammation). Nevertheless, it is also recognised that epistaxis can be induced after some drugs intake. AIMS: Due to the increasing use of drugs or drug combinations that potentially may induce epistaxis, this review aims to alert healthcare professionals for this often neglected adverse drug effect and its possible complications...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29437013/a-probable-topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#15
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29345598/dolutegravir-related-neurological-adverse-events-a-case-report-of-successful-management-with-therapeutic-drug-monitoring
#16
Francois Parant, Patrick Miailhes, Florence Brunel, Marie-Claude Gagnieu
Dolutegravir (DTG), a highly effective second-generation HIV integrase inhibitor with high genetic barrier to resistance, has shown excellent tolerability and safety profiles in clinical trials. However, some patients may experience neurological or psychiatric adverse effects leading to DTG discontinuation. This report describes a case of 29-year-old woman who developed neurological adverse events after starting the DTG-based antiretroviral therapy. Serum DTG concentrations were supra-therapeutic which has required a dosing interval adjustment...
January 16, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29600918/preface
#17
Seetal Dodd
No abstract text is available yet for this article.
2018: Current Drug Safety
https://www.readbyqxmd.com/read/29359677/comparative-randomized-crossover-clinical-study-for-the-evaluation-of-erectile-dysfunction-medications-via-novel-pentagon-system
#18
Mohamed I Nounou, Ghada El Haddad, Fatema El Amrawy, Ola El Gaddar, Ahmed El Yazbi, Ahmed Eshra
INTRODUCTION: Due to the chaos in the legislation in the Middle East, male enhancement nutraceuticals may be sold without any registration or evaluation. These products need to be evaluated with respect to safety and efficacy. Furthermore, cultural and social considerations in the Middle East prevent the use of international evaluations schemes for erectile dysfunction. AIM: Evaluating the safety and efficacy parameters of generic and nutraceutical products for erectile dysfunction in the Middle East through a custom-designed, representable and simple system tailored to the regional culture...
2018: Current Drug Safety
https://www.readbyqxmd.com/read/29086700/glaucoma-drug-therapy-in-pregnancy-literature-review-and-teratology-information-service-tis-case-series
#19
Marcella Pellegrino, Luisa D'Oria, Carmen De Luca, Giacomina Chiaradia, Angelo Licameli, Caterina Neri, Marta Nucci, Daniela Visconti, Alessandro Caruso, Marco De Santis
BACKGROUND: There are many contradictions about pregnancy and fetal/neonatal outcomes after topical use of timolol alone or timolol in combination with other antiglaucoma medications. METHODS: Seventy-five pregnant women exposed to antiglaucoma medications were followed prospectively by phone interviews. 27 women used timolol as monotherapy, 48 women used timolol as a part of multidrug therapy. We selected a control group of 187 healthy pregnant women. RESULTS: Topical use of timolol alone or timolol in combination with other antiglaucoma medications does not influence pregnancy or fetal/neonatal outcomes...
2018: Current Drug Safety
https://www.readbyqxmd.com/read/29256354/knowledge-practice-and-attitudes-toward-pharmacovigilance-and-adverse-drug-reactions-reporting-process-among-health-care-providers-in-dammam-saudi-arabia
#20
Mohammad Daud Ali, Yousif Amin Hassan, Ayaz Ahmad, Sana Almahmoud, Orjwan Alaqel, Hadeel Khlid Al-Harbi, Nada Mohammed Al-Suhaimi
BACKGROUND: Pharmacovigilance is the science that plays an essential role in the reduction of ADRs which helps in predict unwanted effects of drugs in community. Studying adverse drug reaction is an important arm of patient care. It aims at making the safe use of medicines for the treatment or prevention of disease. OBJECTIVES: To assess knowledge, Practice and attitudes toward pharmacovigilance and adverse drug reactions reporting process among Health Care Providers in Dammam, KSA...
December 18, 2017: Current Drug Safety
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