Read by QxMD icon Read

Current Drug Safety

Sami Joseph Giryes, Zaher Azzam, Reem Ismael-Badarneh, Norberto Krivoy, Gidon Berger
Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia. The patient was treated with Tigecycline and few days later he developed "Disseminated intravascular coagulation (DIC)" like coagulation study abnormality. Tigecycline was suspected to cause this coagulation study abnormality and was stopped, and few days later coagulation studies return to normal values...
September 19, 2016: Current Drug Safety
Nasser Mikhail
Technoshere insulin (TI), Afrezza, is a form of short-acting human insulin taken by oral inhalation with meals. Compared to subcutaneous insulin aspart, TI is slightly less effective, the difference in hemoglobin A1c (HbA1c) reduction being 0.19%. Use of TI is associated with lower risk of hypoglycemia and weight gain compared with insulin aspart. Apart from hypoglycemia, cough is the most common adverse effect of TI reported by 24-33% of patients. Cough induced by TI is mostly dry, occurs within 10 minutes after inhalation and usually subsides after few weeks of use...
August 29, 2016: Current Drug Safety
Nicole Palazzolo, Bridgette Kram, Andrew J Muzyk
OBJECTIVE: To determine the extent of QTc prolongation following administration of an atypical antipsychotic in critically ill patients diagnosed with delirium and to conduct an assessment of risk factors to identify the presence of specific risk factors associated with QTc prolongation in this patient population. METHODS: Patients were included if they were at least 18 years of age, admitted to an Intensive Care Unit (ICU) at the study institution from July 1, 2013 through January 30, 2014, had a documented diagnosis of delirium within their electronic medical record, and received an atypical antipsychotic for delirium during their hospital admission...
August 15, 2016: Current Drug Safety
Andrew D Fraser, Boshi Zhang, Henry Ma, Hassan Khan, Elliot V Hersh
As the use of prescription opioid drugs for non-therapeutic means increases, rampant dental decay is a serious disease that can develop. The dentist must prepare to treat these complex patients with comprehensive care while working in cooperation with an entire healthcare team. The article explores this phenomenon in a twenty-six year-old who abused prescription opioids for three years.
August 3, 2016: Current Drug Safety
Emanuele A Alves, Pedro Brandão, Teresa Magalhães, Félix Carvalho, Ricardo J Dinis-Oliveira
Fatal intoxications are a topic of great relevance in today's society. This study retrospectively reviews fatal intoxication cases autopsied at the northern forensic medicine services of Portugal, between 2001 and 2013. For this purpose, we analyzed postmortem forensic medical reports with positive results for the presence of xenobiotics. A total of 27,778 autopsy reports were analyzed, of which 1,269 cases fulfilled the selection criteria, representing 4.6% of total number of individuals autopsied during the period under analysis...
July 24, 2016: Current Drug Safety
Khyati Doshi, Radha Yegnanarayan, Neeta Gokhale
OBJECTIVES: Find possible causative agents causing cutaneous adverse reactions; clinical patterns, causality and severity of Drug induced cutaneous adverse reactions (CADR) and treatment outcome. METHODS: Retrospective study was undertaken including cases of CADR. Causality, preventability and severity of Drug Induced cutaneous reactions were judged with the use of Naranjo's algorithm, WHO causality scale, modified Schumock and Thorton scale, and Hartwig's scale respectively...
July 24, 2016: Current Drug Safety
Subramoniam Madhusoodanan, Leah R Steinberg, Alisa Coleman, Samuel Bavli
BACKGROUND: Hyperprolactinemia can be caused by medications, primarily antipsychotics, or by anterior pituitary tumors. The consequences of hyperprolactinemia including gynecomastia, galactorrhea, and sexual dysfunction are very disturbing for males and females. It is sometimes difficult to differentiate the etiology of hyperprolactinemia from a clinical perspective. OBJECTIVE: Identification of the etiology of hyperprolactinemia requires a careful review of the causes and appropriate work-up...
July 19, 2016: Current Drug Safety
Benjamin Maslin, Lawrence Lipana, Brandon Roth, Gopal Kodumudi, Nalini Vadivelu
BACKGROUND: Ketorolac use has significantly expanded for postoperative pain management since it first became available in the United States, primarily due to well established effects on patient pain scores and its ability to reduce perioperative opioid requirements. As an inhibitor of cyclooxygenase, ketorolac use has raised clinical concern including particular controversy regarding its potential effects on bone healing, postoperative kidney function and perioperative bleeding. OBJECTIVE: To review the supporting data from clinical studies addressing the safety of ketorolac use for postoperative pain...
July 19, 2016: Current Drug Safety
Harmeet Singh Rehan, Ravinder Sah, Anubhuti Gupta, Parvesh Nagar
BACKGROUND: The Pharmacovigilance Program of India recently initiated a process for direct patient reporting of Adverse Drug Reactions (ADRs) with a designated form. PATIENTS AND METHODS: A survey of 200 patients reporting ADRs filling the form. Forms were analyzed for patient data, the suspected medication(s), ADRs and possible causality. RESULTS: 54.3% of respondents provided their contact information; the implicated medicine was mentioned in 60% and the description of ADRs in 80% although 46...
May 18, 2016: Current Drug Safety
Khushboo Gajjar, Hiren Hirapara, Chandra S Jaiswal, Manish Barvaliya, Hita Shah, C B Tripathi
We report a case of 25 years old male patient with antitubercular drugs induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity between ciprofloxacin and levofloxacin might be responsible for causing this reaction. Issues of cross sensitivity should be kept in mind and the same class of drugs should strictly be avoided to prevent such complications.
April 26, 2016: Current Drug Safety
M S Brochet, M Harry, F Morin
BACKGROUND: It is known that calcium channel blockers are associated with a risk of gingival hyperplasia. These drugs are widely used in the management of gestational hypertensive disorders. CASE: A 27-year-old G1 woman presented with gingival hyperplasia at 27 weeks gestation during a hospitalisation for preeclampsia. She had been on nifedipine for hypertension for the last 9 weeks. Nifedipine was discontinued and replaced by methyldopa and already after 48 hours the gingival hyperplasia improved...
April 26, 2016: Current Drug Safety
Piero Vasapollo, Erika Cione, Filippo Luciani, Luca Gallelli
Selective agents able to locate and identify unique targets represent a crucial aspect of modern pharmacology. The exclusive location of sodium-glucose co-transporter-2 (SGLUT2) on kidneys prompt companies to develop SGLT2 inhibitors that today are the latest class of drugs for diabetes treatment. In particular, canagliflozin blocks the re-absorption of glucose in the kidney lowering blood glucose levels by increasing glucose excretion. We report a 61-year old woman who developed an intense and severe pruritus during the treatment with canagliflozin...
April 5, 2016: Current Drug Safety
Sonia Chaabane, Odile Sheehy, Patricia Monnier, William Fraser, François Bissonnette, Jaquetta M Trasler, Flory T Muanda, Takoua Boukhris, Fatiha Karam, Fabiano Santos, Lucie Blais, Anick Bérard
INTRODUCTION: Multiple pregnancies are a recognized adverse effect of assisted reproductive technologies; nevertheless, there is no consensus on the incremental risk associated with the ovarian stimulation (OS) used alone and intrauterine insemination (IUI). The relationship between OS and IUI and the risk of major congenital malformations (MCM) is unclear. OBJECTIVE: To summarise the literature and evaluate the risk of multiple pregnancy and MCM associated with OS used alone and IUI used with or without OS compared to natural conception (spontaneously conceived infants without any type of fertility treatments)...
2016: Current Drug Safety
Fernando Bril, Veronica Castro, Ignacio G Centurion, Jeronimo Espinosa, Guillermo A Keller, Claudio D Gonzalez, Maria C Soler Riera, Cristian L Saubidet, Guillermo Di Girolamo, Gervasio S Pujol, Paulino A Alvarez
AIM: Renal transplant patients are frequently subject to polypharmacy and drug-drug interactions. However, no previous study has systematically assessed the risk of drug interactions and Adverse Drug Reactions (ADRs) in this population. METHODS: A total of 138 consecutive adult kidney transplant recipients admitted to our hospital between August 2010 and February 2012 were prospectively and systematically assessed by our pharmacovigilance team, within 24 hours of admission, to identify potential drug-drug interactions and probable ADRs...
2016: Current Drug Safety
Nina Keldsen, Maria L Jöhnk, June A Ejlersen
BACKGROUND: Forty-seven cases (38 men and 9 women) of pulmonary toxicity caused by oxaliplatin have previously been published, but the issue has not been investigated in a prospective setting. Our purpose was to assess how oxaliplatin affects the pulmonary function in colorectal cancer patients during adjuvant treatment. MATERIAL AND METHODS: Forty patients (median age 57.5 years, range 33-74) radically resected for colorectal cancer, underwent three pulmonary function tests during post-surgery adjuvant treatment with oxaliplatin...
2016: Current Drug Safety
Dharamvirsinh Jadeja, Vipul Solanki, Bhavesh Chavada, Chandrabhanu Tripathi
A 28 year old male patient, known case of pemphigus vulgaris was on dexamethasone pulse therapy. Total 7 pulses were given after that he developed avascular necrosis of head of femur on both sides, which was confirmed by digital X- ray and MRI. Avascular necrosis is a disabling and progressive condition in young patients gradually leads to femoral head collapse and eventual total hip arthroplasty. As per WHO-UMC causality assessment criteria, the association between reaction and drug was possible, Naranjo's score was 7...
2016: Current Drug Safety
Siddhartha Sinha, Jayati Simlai, Samir K Praharaj
Clozapine is an antipsychotic drug recommended for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87-100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea...
2016: Current Drug Safety
Donna-Ann Thomas, Mary West, Aron Legler, Benjamin Maslin, Richard K Kim, Nalini Vadivelu
Opioids have been the mainstay for management of acute postoperative pain for several decades. Extensive use, however, has been associated with multiple side effects. Multimodal approaches that incorporate nonopioid medications and techniques have been observed to achieve optimum pain control whilst decreasing side effects. Such strategies are particularly important to consider for opioid-dependent and tolerant patients with various comorbidities undergoing different types of surgery. This review assesses recent data on nonopioid analgesics for postoperative pain control, highlighting evidence of their safety profiles in contemporary pain management...
2016: Current Drug Safety
Upinder Kaur, Sankha Shubhra Chakrabarti, Indrajeet Singh Gambhir
Zoledronate is a Nitrogen containing bisphosphonate (NBP) used in many conditions like osteoporosis, Paget's disease and hypercalcemia of malignancy. Unlike oral bisphosphonates, Zoledronate is not seen to be associated with gastroesophageal side effects but the drug is not free of certain rare but life threatening adverse effects like hypocalcemia and renal deterioration. Majority of cases of hypocalcemia with Zoledronate are seen in patients with underlying malignancy and are asymptomatic. Here we present a case of severe symptomatic hypocalcemia along with hypophosphatemia following zoledronate administration in an elderly male with a history of osteoporotic fracture...
2016: Current Drug Safety
Hiral N Golakiya, Hiren N Hirapara, Sugnesh J Parmar, Viren N Naik, Chandrabhanu B Tripathi
Intravitreal triamcinolone and bevacizumab are emerging treatment modalities for the patients of macular oedema; however, they are known to raise intraocular pressure. A 61 year old diabetic male patient developed glaucoma after administration of triamcinolone acetonide and bevacizumab intravitreally for treatment of macular oedema. His intraocular pressure was raised up to about 42 mm Hg. Such high and sustained rise in intraocular pressure may lead to vision loss by damaging the optic nerve. The patient was managed by local as well as systematic therapy and was recovered after 1 month from the occurrence of an event...
2016: Current Drug Safety
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"