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Targeted Oncology

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https://www.readbyqxmd.com/read/30519815/pd-1-and-pd-l1-expression-in-male-breast-cancer-in-comparison-with-female-breast-cancer
#1
Quirine F Manson, Natalie D Ter Hoeve, Horst Buerger, Cathy B Moelans, Paul J van Diest
BACKGROUND: Male breast cancer is rare, as it represents less than 1% of all breast cancer cases. In addition, male breast cancer appears to have a different biology than female breast cancer. Programmed death-1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), seem to have prognostic and predictive values in a variety of cancers, including female breast cancer. However, the role of PD-1 and PD-L1 expression in male breast cancer has not yet been studied. OBJECTIVES: To compare PD-1 and PD-L1 expression in male breast cancer to female breast cancer and to evaluate prognostic values in both groups...
December 5, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30488350/gemcitabine-combined-with-the-mtor-inhibitor-temsirolimus-in-patients-with-locally-advanced-or-metastatic-pancreatic-cancer-a-hellenic-cooperative-oncology-group-phase-i-ii-study
#2
Vasilios Karavasilis, Epaminontas Samantas, Georgia-Angeliki Koliou, Anna Kalogera-Fountzila, George Pentheroudakis, Ioannis Varthalitis, Helena Linardou, Grigorios Rallis, Maria Skondra, Georgios Papadopoulos, George Papatsibas, Joseph Sgouros, Athina Goudopoulou, Konstantine T Kalogeras, Christos Dervenis, Dimitrios Pectasides, George Fountzilas
BACKGROUND: The prognosis of patients with advanced pancreatic cancer is dismal, and there is a need for novel and effective treatments. OBJECTIVES: Tο determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of a novel gemcitabine (G) and temsirolimus (T) combination (phase I) and estimate the 6-month progression-free survival (PFS) in patients treated with the T + G combination (phase II). PATIENTS AND METHODS: Eligible patients with histologically confirmed inoperable or metastatic pancreatic carcinoma (MPC) were entered into the trial...
November 28, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30470972/new-horizons-in-the-treatment-of-metastatic-pancreatic-cancer-a-review-of-the-key-biology-features-and-the-most-recent-advances-to-treat-metastatic-pancreatic-cancer
#3
Helena Verdaguer, Alvaro Arroyo, Teresa Macarulla
Only a limited number of therapeutic strategies are available for patients diagnosed with pancreatic adenocarcinoma, and disease recurrence and mortality are consequently high. For metastatic disease, two combinations are approved in the first line setting: a triplet with 5-fluoruracil, irinotecan, and oxaliplatin, and the combination of gemcitabine and nab-paclitaxel. In patients who have progressed on gemcitabine, a new nanoliposomal formulation of irinotecan has recently been approved. While these treatments have demonstrated some efficacy, there has been little increase in survival rates for metastatic pancreatic cancer patients...
November 23, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30456461/olaparib-tablet-a-review-in-ovarian-cancer-maintenance-therapy
#4
REVIEW
Young-A Heo, Sohita Dhillon
Olaparib (Lynparza®), a first-in-class poly (ADP-ribose) polymerase (PARP) inhibitor, has recently been approved in a new tablet formulation as maintenance treatment for recurrent high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who are in complete or partial response to platinum-based chemotherapy. Relative to an earlier capsule formulation, the tablet formulation of olaparib has improved bioavailability, thereby reducing pill burden and offering a more convenient dosage regimen...
November 20, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30446872/real-world-use-and-outcomes-of-olaparib-a-population-based-cohort-study
#5
Irene Eriksson, Björn Wettermark, Kjell Bergfeldt
BACKGROUND: Although olaparib, the first poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor approved, has been used in routine clinical practice for over three years, little has been published on its uptake, utilization patterns, and clinical outcomes. OBJECTIVE: To examine real-world use and outcomes of olaparib treatment in Swedish patients during the first three years following regulatory approval. PATIENTS AND METHODS: This is a population-based cohort study using data from the Swedish national registers...
November 16, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30446871/targeting-the-proteasome-in-refractory-pediatric-leukemia-cells-characterization-of-effective-cytotoxicity-of-carfilzomib
#6
Lucy Swift, Aarthi Jayanthan, Yibing Ruan, Ronald Anderson, Jessica Boklan, Tanya Trippett, Aru Narendran
BACKGROUND: Leukemia accounts for 30% of all childhood cancers and although the survival rate for pediatric leukemia has greatly improved, relapse is a major cause of treatment failure. Therefore, the development and introduction of novel therapeutics to treat relapsed pediatric leukemia is urgently needed. The proteasome inhibitor bortezomib has been shown to be effective against adult hematological malignancies such as multiple myeloma and lymphoma, but is frequently associated with the development of resistance...
November 16, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30426327/annual-congress-of-the-european-society-for-medical-oncology-esmo-munich-germany-19-23-october-2018
#7
Martin Chopra
No abstract text is available yet for this article.
November 13, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30406444/evaluation-of-the-predictive-and-prognostic-values-of-stromal-tumor-infiltrating-lymphocytes-in-her2-positive-breast-cancers-treated-with-neoadjuvant-chemotherapy
#8
Xia Yang, Jia Rao, Wentao Yang, Ruohong Shui
BACKGROUND: Stromal tumor-infiltrating lymphocytes (sTILs) have been identified as a predictive biomarker for response to neoadjuvant chemotherapy (NAC) and prognosis in human epidermal growth factor receptor 2 (HER2)-positive breast cancers. However, standardized scoring methods for use in clinical practice need to be established, and the optimal threshold of sTILs to predict pathological complete response (pCR) and prognosis in HER2+ breast cancers has not yet been defined. OBJECTIVE: The predictive and prognostic values of sTILs in patients with HER2-positive breast cancer treated with NAC were evaluated, with the aim to explore the optimal thresholds of sTILs and to investigate the feasibility of scoring methods in clinical practice...
November 7, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30353488/impact-of-delayed-addition-of-anti-egfr-monoclonal-antibodies-on-the-outcome-of-first-line-therapy-in-metastatic-colorectal-cancer-patients-a-retrospective-registry-based-analysis
#9
Ondrej Fiala, Veronika Veskrnova, Renata Chloupkova, Alexandr Poprach, Igor Kiss, Katerina Kopeckova, Ladislav Dusek, Lubomir Slavicek, Milan Kohoutek, Jindrich Finek, Marek Svoboda, Lubos Petruzelka, Ludmila Boubliková, Josef Dvorak, Bohuslav Melichar, Tomas Buchler
BACKGROUND: The addition of monoclonal antibodies targeting the epidermal growth factor receptor (anti-EGFR Abs) to chemotherapy for metastatic colorectal carcinoma (mCRC) is commonly delayed in the real-world clinical practice, usually because of late RAS testing results. OBJECTIVE: To determine whether delayed addition of anti-EGFR mAbs up to the fourth cycle of backbone chemotherapy adversely affected outcomes of mCRC patients treated with first-line regimens...
October 23, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30328067/effect-of-changes-in-skeletal-muscle-mass-on-oncological-outcomes-during-first-line-sunitinib-therapy-for-metastatic-renal-cell-carcinoma
#10
Hiroki Ishihara, Toshio Takagi, Tsunenori Kondo, Hironori Fukuda, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe
BACKGROUND: Sarcopenia is a state of degenerative skeletal muscle wasting induced by cancer cachexia. OBJECTIVE: To evaluate the prognostic impact of changes in skeletal muscle mass (SMM) during first-line sunitinib therapy on oncological outcomes in metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS: Sixty-nine patients were evaluated retrospectively. The skeletal muscle index (SMI) was calculated based on computed tomography images obtained before the initiation (pre-treatment SMI) and after two cycles of sunitinib treatment (post-treatment SMI)...
October 16, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30324488/should-carmena-really-change-our-attitude-towards-cytoreductive-nephrectomy-in-metastatic-renal-cell-carcinoma-a-systematic-review-and-meta-analysis-evaluating-cytoreductive-nephrectomy-in-the-era-of-targeted-therapy
#11
REVIEW
Francesco Massari, Vincenzo Di Nunno, Lidia Gatto, Matteo Santoni, Riccardo Schiavina, Laura Cosmai, Eugenio Brunocilla, Andrea Ardizzoni, Camillo Porta
BACKGROUND: Cytoreductive nephrectomy in metastatic renal cell carcinoma (mRCC) patients has been common clinical practice due to evidence that resection of the primary tumor results in a survival benefit regardless of systemic treatment. Recently, the first large phase III randomized, non-inferiority prospective clinical trial evaluating this surgical approach demonstrated that systemic treatment alone was not inferior to primary surgery plus systemic treatment. OBJECTIVE: Our aim was to evaluate if cytoreductive nephrectomy results in a survival benefit over systemic treatment alone in patients with mRCC and in specific subgroups, including patients with brain metastases, poor performance status, poor prognosis according to IMDC or MSKCC criteria, and clear cell and non-clear cell histologies...
October 15, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30306460/low-baseline-serum-sodium-concentration-is-associated-with-poor-clinical-outcomes-in-metastatic-non-small-cell-lung-cancer-patients-treated-with-immunotherapy
#12
Giovanni Fucà, Giulia Galli, Marta Poggi, Giuseppe Lo Russo, Claudia Proto, Martina Imbimbo, Milena Vitali, Monica Ganzinelli, Claudia Lanti, Giuliano Molino, Fabiano Stangoni, Nicoletta Zilembo, Filippo de Braud, Marina Chiara Garassino, Diego Signorelli
BACKGROUND: A consistent percentage of patients with metastatic non-small cell lung cancer (NSCLC) derives no or only marginal benefit from immunotherapy (IO). OBJECTIVE: Since serum sodium has been linked to both prognosis in NSCLC and modulation of immune cells activity, we aimed to assess the association between low baseline serum sodium concentration (≤ 135 mEq/L) and clinical outcomes of patients with metastatic NSCLC treated with IO. PATIENTS AND METHODS: We included metastatic NSCLC patients treated with checkpoint inhibitors in our department from April 2013 to April 2018 with available baseline serum sodium concentration...
October 10, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30280283/correction-to-medical-treatment-options-for-patients-with-epidermal-growth-factor-receptor-mutation-positive-non-small-cell-lung-cancer-suffering-from-brain-metastases-and-or-leptomeningeal-disease
#13
https://www.readbyqxmd.com/read/30218431/characteristics-and-response-to-crizotinib-in-alk-rearranged-advanced-non-adenocarcinoma-non-small-cell-lung-cancer-na-nsclc-patients-a-retrospective-study-and-literature-review
#14
Bo Zhang, Yanwei Zhang, Jianlin Xu, Xueyan Zhang, Tianqing Chu, Shuyuan Wang, Jie Qian, Rong Qiao, Jun Lu, Lele Zhang, Baohui Han
BACKGROUND: Oncogenic fusion genes consisting of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) can be detected in 5-7% of lung adenocarcinoma cases. The prevalence of ALK rearrangement in non-adenocarcinoma, non-small cell lung cancers (NA-NSCLC) is currently unknown. In addition, the efficacy of crizotinib in these patients has not been well established. OBJECTIVES: The aim of this study was to investigate the prevalence of ALK rearrangement in NA-NSCLC patients and the therapeutic efficacy of crizotinib in these patients...
September 14, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30302723/tumor-type-agnostic-treatment-and-the-future-of-cancer-therapy
#15
EDITORIAL
Luis E Raez, Edgardo S Santos
No abstract text is available yet for this article.
October 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30284706/egfr-amplification-and-sensitizing-mutations-correlate-with-survival-in-lung-adenocarcinoma-patients-treated-with-erlotinib-mutp-clicap
#16
Alejandro Ruiz-Patiño, Christian David Castro, Luisa María Ricaurte, Andrés F Cardona, Leonardo Rojas, Zyanya Lucia Zatarain-Barrón, Beatriz Wills, Noemí Reguart, Hernán Carranza, Carlos Vargas, Jorge Otero, Luis Corrales, Claudio Martín, Pilar Archila, July Rodriguez, Jenny Avila, Melissa Bravo, Luis Eduardo Pino, Rafael Rosell, Oscar Arrieta
BACKGROUND: Non-small cell lung cancer (NSCLC) has a 5-year survival of 5-16%. Epidermal growth factor receptor (EGFR) mutations, in most cases, confer sensitivity to EGFR tyrosine kinase inhibitor (TKI) therapy. Nonetheless, it is still unclear why clinical outcomes vary among patients with identical EGFR mutations. The amplification of the EGFR gene (EGFRamp) may play a significant role. OBJECTIVE: Compare the complete (CR) and partial response (PR) rates, overall survival (OS), and progression-free survival (PFS) in Hispanic patients with lung adenocarcinoma treated with erlotinib with EGFR mutations (L858R or exon 19 deletion [Del19]) with and without concomitant EGFRamp...
October 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30276762/trk-inhibition-a-new-tumor-agnostic-treatment-strategy
#17
Shivaani Kummar, Ulrik N Lassen
Oncogenic somatic chromosomal rearrangements involving the NTRK1, NTRK2 or NTRK3 genes (NTRK gene fusions) occur in up to 1% of all solid tumors, and have been reported across a wide range of tumor types. The fusion proteins encoded by such rearranged sequences have constitutively activated TRK tyrosine kinase domains, providing novel therapeutic anticancer targets. The potential clinical effectiveness of TRK inhibition in patients with tumors harboring NTRK gene fusions is being assessed in phase I and II trials of TRK inhibitors, such as larotrectinib and entrectinib...
October 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30267200/immunological-correlates-of-response-to-immune-checkpoint-inhibitors-in-metastatic-urothelial-carcinoma
#18
Alice Tzeng, C Marcela Diaz-Montero, Patricia A Rayman, Jin S Kim, Paul G Pavicic, James H Finke, Pedro C Barata, Marcelo Lamenza, Sarah Devonshire, Kim Schach, Hamid Emamekhoo, Marc S Ernstoff, Christopher J Hoimes, Brian I Rini, Jorge A Garcia, Timothy D Gilligan, Moshe C Ornstein, Petros Grivas
BACKGROUND: The identification of prognostic and/or predictive biomarkers for response to immune checkpoint inhibitors (ICI) could help guide treatment decisions. OBJECTIVE: We assessed changes in programmed cell death-1 (PD1)/PD1 ligand (PDL1) expression in key immunomodulatory cell subsets (myeloid-derived suppressor cells [MDSC]; cytotoxic T lymphocytes [CTL]) following ICI therapy and investigated whether these changes correlated with outcomes in patients with metastatic urothelial carcinoma (mUC)...
October 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30259313/everolimus-exposure-and-early-metabolic-response-as-predictors-of-treatment-outcomes-in-breast-cancer-patients-treated-with-everolimus-and-exemestane
#19
Annelieke E C A B Willemsen, Lioe-Fee de Geus-Oei, Maaike de Boer, Jolien Tol, Yvonne Kamm, Paul C de Jong, Marianne A Jonker, Allert H Vos, Willem Grootjans, Johannes W B de Groot, Sasja F Mulder, Erik H J G Aarntzen, Winald R Gerritsen, Carla M L van Herpen, Nielka P van Erp
BACKGROUND: Treating breast cancer patients with everolimus and exemestane can be challenging due to toxicity and suboptimal treatment responses. OBJECTIVE: We investigated whether everolimus exposure and early metabolic response are predictors for toxicity and effectiveness in these patients. PATIENTS AND METHODS: We performed pharmacokinetic assessments 14 and 35 days after starting treatment. [18 F]fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET) was performed at baseline, and 14 and 35 days after the start of the therapy...
October 2018: Targeted Oncology
https://www.readbyqxmd.com/read/30232691/immediate-progressive-disease-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-nivolumab-a-multi-institution-retrospective-study
#20
Hiroki Ishihara, Tsunenori Kondo, Toshio Takagi, Hidekazu Tachibana, Hironori Fukuda, Kazuhiko Yoshida, Junpei Iizuka, Hirohito Kobayashi, Kazunari Tanabe
BACKGROUND: Investigations on rapid disease progression in patients with urologic malignancies treated with immune checkpoint inhibitors are currently lacking. OBJECTIVE: The objective of this study was to assess cases of rapid disease progression/immediate development of progressive disease (immediate PD) in patients with pretreated metastatic renal cell carcinoma (mRCC) treated with nivolumab. PATIENTS AND METHODS: Forty patients were retrospectively evaluated...
October 2018: Targeted Oncology
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