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Infectious Disorders Drug Targets

Babak Pourakbari, Korosh Yousefi, Shima Mahmoudi, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
Mycobacterium tuberculosis remains as a vital threat to global health and its diagnosis is still complicated. Since there is no gold standard for the diagnosis of latent tuberculosis infection (LTBI), its diagnosis routinely relies on measurement of host immune responses to M. tuberculosis antigens using the tuberculin skin test (TST) and Interferon-Ă│ release assays (IGRAs). The aim of this study was to evaluate LTBI among hospitalized children and their patents/guardians as general populations in Children Medical Center, an Iranian referral hospital...
February 28, 2018: Infectious Disorders Drug Targets
Kazem Baesi, Marzyeh Nili, Katayoun Tayeri, Mohamad Gholami, Samaneh Moallemi, Farzaneh Sabahi, Saber Kalhori, Mehrdad Hasibi
BACKGROUND: The rate of human immunodeficiency virus type 1 (HIV-1) infection in Iran has increased dramatically in the past few years. HIV-1 genome sequences are pivotal for large-scale studies of inter- and intra-host evolution. To understand the molecular difference between reference HIV-1 isolate and two HIV-1 infected patients in Iran, we conducted this study to analyze some genome segments of Iranian HIV-1 isolates. METHODS: Two HIV-1-infected individuals who were under antiretroviral therapy (ARV) for 8 years with stable clinical status were enrolled...
February 21, 2018: Infectious Disorders Drug Targets
Molouk Beiromvand, Abdollah Rafiei, Esmat Panabad
INTRODUCTION: Cystic echinococcosis is a neglected zoonotic disease with worldwide distribution, which occurs mainly in pastoral regions. Echinococcus granulosus sensu stricto, is the main agent of human infection. Although Iran is an endemic area for CE in the Middle East, lack of data regarding the disease among rural inhabitants of Khuzestan province in recent years, persuaded us to perform the current study. METHODOLOGY: This cross-sectional study was conducted in 2016 using simple random sampling method in 15 villages of Shushtar county, southwestern Iran...
February 13, 2018: Infectious Disorders Drug Targets
Luciana Dias Ghiraldi-Lopes, Paula Aline Zanetti Campanerut-Sa, Geisa Paulino Caprini Evaristo, Jean Eduardo Meneguello, Adriana Fiorini, Vanessa Pietrowski Baldin, Emanuel Maltempi de Souza, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Rosilene Fressatti Cardoso
BACKGROUND: In recent years, very few effective drugs against Mycobacterium tuberculosis (M. tb) have emerged which motivates the research with drugs already used in the treatment of tuberculosis. EMB is a bacteriostatic drug that affects cell wall integrity, but the effects of this drug on bacilli are not fully exploited. OBJECTIVE: Based on the need to better investigate the complex mechanism of action of EMB, our study presented the proteome profile of M. tb after different times of EMB exposure, aiming to comprehend the dynamics of bacilli response to its effects...
January 24, 2018: Infectious Disorders Drug Targets
Leila Sadeghi, Samaneh Moallemi, Reza Adl Tabatabai, Reza Adl Tabatabai, Ali Esmaeilzadeh, Sara Ahsani-Nasab, Niloofar Eghbal Ahmadi, Saeed Bayanolhagh, Mahin Lolaie, Arsalan Narouei, Ahmad Alinaghi, Minoo Mohraz
The initial ART regimens used by most national treatment guidelines in resource-limited settings include 2 nucleoside reverse-transcriptase inhibitors (NRTIs) and 1 non-nucleoside reverse-transcriptase inhibitor (NNRTI). The NRTIshave consistedof Zidovudine (AZT) or Stavudine (d4T) with Lamivudine (3TC); the NNRTI component hasbeen Nevirapine (NVP) or Efavirenz (EFV). There exists few data indicating if Vonavir is more effective in increasing CD4+ T cell counts or other first-line drugs of ART.Immunological outcomes of 134 individuals who just started antiretroviral therapy with Vonavir or Zidovudine/Lamivudine and Efavirenzanalyzed...
January 7, 2018: Infectious Disorders Drug Targets
Nadia Elwan, Fathia Assal, Asem Elfert, Lobna AboAli, Shaimaa Soliman, Samah Soliman, Walaa Elkhalawany, Rehab Badawy, Laila Effat, Khalda Sayed, Safinaz Shalaby, Marwa Shehab, Mohamed Abdel-Hamid, Sherief Abd-Elsalam
AIM: The research was conducted to study Interleukin (IL)-12B gene polymorphism in families of Hepatitis C virus (HCV) infected patients in Egypt. METHODS: Three hundreds HCV patients, 860 family members and 100 healthy subjects were studied. All family members were screened for HCV antibodies by enzyme-linked immunosorbent assay (ELISA). Positive cases were examined using Real-Time polymerase chain reaction (PCR) to confirm the presence of HCV ribonucleic acid (RNA) and detect the viral load...
December 27, 2017: Infectious Disorders Drug Targets
Mahmoud M Elhefnawi, Mohamed E Hasan, Amal Mahmoud, Yehia A Khidr, El-Sayed A El-Absawy, Alaa A Hemeida
BACKGROUND: The p7-transactivated protein of Hepatitis C virus is a small integral membrane protein of 127 amino acids, which is crucial for assembly and release of infectious virions. Ab initio and comparative modelling, is an essential tool to solve the problem of protein structure prediction and to comprehend the physicochemical fundemental of how proteins fold in nature. RESULTS: Only one domain (1-127) of p7 had been predicted using the systematic in silico approach, ThreaDom...
December 15, 2017: Infectious Disorders Drug Targets
Hourieh Alkadi, Mohamad Jowad Khubeiz, Rajwa Jbeily
For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it...
October 17, 2017: Infectious Disorders Drug Targets
Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi, Mina Moradzadeh, Masoumeh Mahzari, Mohammad TaghiHaghi Ashtiani, Parin Tanzifi
BACKGROUND: Bloodstream infections (BSI) are considered as a serious cause of morbidity and mortality in pediatricschildren. The aim of this study was to depict report the common Gram-positive bacteria (GPB) responsible for bloodstream infections in children and determine their antimicrobial resistance patterns in Children Medical Center Hospital (CMC), ) Hospital, Tehran, Iran. METHODS: This retrospective study was conducted within a six-year period (March 2011 to September 2016) for pediatric patients with BSI...
August 21, 2017: Infectious Disorders Drug Targets
Sajad Khan, Muhammad, Abdur Rauf, Ahsan Khan, Muhammad Rizwan, Seema Patel, Haroon Khan, Adel M Mahasneh, Mohammad S Mubarak
Ebola virus (EBOV) was discovered for the first time in 1976. It belongs to the family Filoviridae, which causes hemorrhagic fever that could lead to death in a few days. West Africa faced a major outbreak where symptoms appeared in the form of chills, myalgia, fever, diarrhea, and vomiting, and the disease finally reached a severe state as a result of hemorrhagic complications and failure of multiple organs. EBOV spreads by contact with body fluids of an infected person such as blood, saliva, urine, and seminal fluid, and also spreads by a contact with contaminated surfaces...
August 16, 2017: Infectious Disorders Drug Targets
Saiqa Andleeb, Anum Naseer, Shaukat Ali, Rozina Ghulam Mustafa, Atiya Zafar, Irsa Shafique, Hsan-Ul-Haq, Muhammad Ismail, Muhammad Saleem, Qaiser Mansoor
BACKGROUND: Human infectious diseases began by various pathogens including bacteria, fungi, viruses, parasites, and protozoans. These infectious agents are controlled by using synthetic drugs as well as natural sources. AIM OF STUDY: Methods: In current research antibacterial effect of Rumex hastatus was analyzed against seven clinical pathogenic bacteria such as Escherichia coli, Serratia marcescens, Streptococcus pyogenes, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruiginosa through agar well diffusion method...
July 28, 2017: Infectious Disorders Drug Targets
Pegah Shakib, Rashid Ramazanzadeh, Morovat Taherikalani, Bijan Nouri
BACKGROUND: Production of Beta-Lactamase enzymes, especially extended-spectrum Beta -Lactamases (ESBL), is a primary mechanism of resistance in these bacteria. The purpose of this study was detection of blaTEM, blaSHV, blaCTX-M, blaCTX-M-15, blaPER and blaVEB in K. pneumoniae, isolated from clinical specimens by the PCR method and antibiotic susceptibility patterns in these strains isolated, in Sanandaj city, Iran. MATERIALS AND METHODS: During a period from October 2015 to July 2016, 52 K...
July 13, 2017: Infectious Disorders Drug Targets
Raheleh Golrokhy, Saeed Jamali, Mehrnoosh Samaei, SeyedAhmad SeyedAlinaghi
Pubic osteomyelitis is a rare disease that typically occurs as a complication of various gynecologic and urologic surgeries. We present a 78 year old woman admitted to the Infectious Department of Imam Khomeini Hospital in June 2014 with pubic osteomyelitis caused by Pseudomonas aeruginosa followed by hysterectomy.
July 13, 2017: Infectious Disorders Drug Targets
Da Yong Lu, Hong Ying Wu, Nagendra Sastry Yarla, Ting-Ren Lu, Bin Xu, Jian -Ding
Ebola epidemic in Africa was outbreak again in 2014 that arises a new wave of panic worldwide. There is a high mortality rates (30-70%) among Ebola infected people in virus-stricken areas. The direct communications between affected countries and rest of world were cut off then. But the medical capabilities against this deadly viral disease were provided by a limited number of agents, several patented agents, biotherapies or prophylactic/therapeutic vaccines have been entering into clinical validations and will be further developed into the global markets-including patents of small molecular chemicals, short sequences or oligomers of DNA/RNA, linkages of chemicals with bio-molecules, herbal medicine and so on...
July 3, 2017: Infectious Disorders Drug Targets
Abdul Baig, Zohaib Rana, H R Ahmad
BACKGROUND: Amiodarone is prescribed for certain cardiac arrhythmias in medical practice. The drug targets and inhibits voltage dependent sodium (Na+v), calcium (Ca+2v), potassium (K+v) channels, and enzymes like cytochrome P450 and oxidosqualene cyclase. Past studies have shown that amiodarone exerts anti-amoebic effects against Trypanosoma cruzi and Acanthamoeba castellanii. OBJECTIVES: The presence of aforementioned targets and the type of cell death induced by amiodarone in these pathogenic eukaryotes like Acanthamoeba castellanii remain to be verified...
June 21, 2017: Infectious Disorders Drug Targets
Ankita Srivastava, Deepak Chandra
BACKGROUND: The unsatisfactory treatment options for Visceral Leishmaniasis (VL), needs identification of new drug targets. Among natural products, Alkaloids have been proved to be highly effective against number of diseases. In Leishmania UDP-galactopyranose mutase (UGM) is a critical enzyme required for cell wall synthesis and thus a drug target for structure based drug designing against L. donovani. OBJECTIVE: To build the homology model of UDP galactopyranse mutase and investigate the interaction of selected alkaloids with this modeled UDP galactopyranose mutase by molecular docking...
June 5, 2017: Infectious Disorders Drug Targets
Syed Qaiser Shah, Mamoona Alam
BACKGROUND: Rifabutin (RFN) is bactericidal antibiotic with a very broad spectrum of activity against gram positive & gram negative organisms including Pseudomonas aeruginosa and specifically Mycobacterium tuberculosis. OBJECTIVE: RFN inhibits DNA dependent RNA polymerase activity in susceptible cells. In the instant work, the therapeutic characteristics of RFN were intended for diagnostic rationale by labeling it with 99mTc (Technetium-99m). The 99mTc labeled RFN (99mTc-RFN) was investigated for labeling capacity, steadiness in saline & serum, in vitro Mycobacterium tuberculosis (MBT) uptake & distribution in MBT stained animal model rats...
June 5, 2017: Infectious Disorders Drug Targets
Nadia Elwan, Khalda Amr, Sahar Elyamany, Walaa Elkhalawany, Shaimaa Soliman, Mohamed Ziada, Sherief Abd-Elsalam
Background &Aims: Cell-mediated immunity plays a critical role in viral clearance and disease progression during Hepatitis C virus (HCV) infection. Interleukin (IL)-12 is a cytokine that has been shown to be a potent antiviral cytokine. The aim of this work is to investigate the association of IL-12 B gene polymorphism with the progression of liver disease in chronic HCV patients. METHODS: This cross sectional study was carried out in tropical medicine department, Tanta university hospital, Egypt, on 120 chronic HCV patients with various stages of liver disease and 30 healthy subjects served as control...
June 5, 2017: Infectious Disorders Drug Targets
Pavan C P K Srimath-Tirumala-Peddinti, Sandeep Solmon Kusuma, Deepthi Nammi, Nageswara Rao Reddy Neelapu
Malaria is a lethal disease causing mortality to over millions each year. Drug resistance in the malarial parasite encouraged to discover effective antimalarial drug targets and drugs. An objective of this current study is to identify drug targets for malarial parasite. Genes unique, non-homologous to humans and essential for parasite are identified using BLASTn by comparing genomes between parasite and host. Further open BLASTp was used to filter the targets specific to Plasmodium species and later were subjected to gene property analysis to identify 65 potential targets...
June 5, 2017: Infectious Disorders Drug Targets
Saifullah Afridi, Jamshed Iqbal, Fareeha Anwar
BACKGROUND: Earlier a century ago, Paul Ehrlich proposed an idea of a drug "magic bullet" that selectively eradicate diseased cells without harming the surrounding normal cells. OBJECTIVE: Since a lot of progress has been attained in this field to discover new horizons for targeted delivery of drug. As major problem in disease therapy is the severe toxic effects of prescribed drugs on healthy cells. In order to reduce the adverse effects of chemotherapy on healthy tissues, herein, we summaries the use of recent drug delivery systems for targeted therapy...
June 5, 2017: Infectious Disorders Drug Targets
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