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Infectious Disorders Drug Targets

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https://www.readbyqxmd.com/read/28079004/foodborne-giardiasis-is-there-any-relationship-between-food-handlers-and-transmission-of-giardia-duodenalis
#1
Molouk Beiromvand, Ehsanallah Mirrezaie, Somayeh Mirzavand
BACKGROUND: The foodborne diseases are the main causes of morbidity and mortality in the human communities. Giardia duodenalis, the causative agent of giardiasis, is one of the foodborne parasites, which has public health importance. The aim of the current study was to assess the prevalence of G. duodenalis among food handlers in Andimeshk County, southwest of Iran. MATERIALS AND METHODS: This cross-sectional study was undertaken among 480 food handlers in 2015...
January 10, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28056752/inhibiting-the-secretion-of-hepatitis-b-surface-antigen-hbsag-to-treat-hepatitis-b-infection-a-review
#2
Simon D Baugh
Chronic Hepatitis B is a major global health issue, and has no known cure. Currently there are over 240 million people infected with the disease, and it leads to the death of over 686,000 people each year. A total of seven treatments which help to control the disease are currently available: interferon-based treatments (pegasys, and interferon alpha), and nucleoside and nucleotide analogs (Viread, Baraclude, Tyzeka, Hepsera, Epivir-HBV), but all require continuing treatment to maintain control of the disease...
January 4, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28042765/study-of-serum-levels-of-some-oxidative-stress-markers-in-children-with-helicobacter-pylori-infection
#3
Adel A Hagag, Saleh M Amin, Rasha B El-Fiky, Magda E El-Sayad
BACKGROUND: Helicobacter pylori are gram-negative spiral shaped bacteria, with sheathed flagella. H. pylori infection is one of the most common chronic infections in humans. Infection is usually acquired during childhood, and becomes a lifelong infection in most people unless treated. The aim of this study was to evaluate serum levels of oxidative stress indices in children with H. pylori infection. MATERIAL AND METHODS: The present study was carried out on 60 children infected with H...
January 2, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28034365/in-vivo-antibacterial-and-wound-healing-activities-of-roman-chamomile-chamaemelum-nobile
#4
Hossein Kazemian, Sobhan Ghafourian, Nourkhoda Sadeghifard, Behzad Badakhsh, Hamid Heidari, Asieh Taji, Aref Shavalipour, Reza Mohebi, Hadi Sedigh Ebrahim-Saraie, Hamidreza Houri, Reza Houshmandfar
BACKGROUND: Today considerable number of drugs are produced from plants. Several plants with antibacterial and healing applications are used in medicine such as Roman chamomile (Chamaemelum nobile L.). Wound infection is one of the most prevalent infections among infectious disease around the world. Due to appearance of drug resistance, researchers are now paying attention to medicinal plants. Therefore, this study was designed to investigate the antimicrobial and wound healing properties of C...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28034364/in-silico-analysis-of-toxins-of-staphylococcus-aureus-for-validating-putative-drug-targets
#5
Ramadevi Mohana, Subhashree Venugopal
Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that causes detrimental effects of human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28034363/the-screening-of-novel-inhibitors-against-leishmania-donovani-calcium-ion-channel-to-fight-leishmaniasis
#6
Mohammad Kashif, Partha Pratim Manna, Yusuf Akhter, Mohammed Alaidarous, Abdur Rub
Leishmania is an intracellular protozoan parasite which causes Leishmaniasis, a global health problem affecting millions of people throughout 89 different countries in the world. The current treatment which includes use of amphotericin B, antimonials, and others has major drawbacks due to toxicity, resistance, and extraordinary high cost. So there is an urgent need of development of new drug targets to fight against leishmaniasis. In this regard we have selected Leishmania donovani Ca2+ ion channel (Ld-CC) as potential drug target...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27919209/evaluation-of-echocardiographic-abnormalities-in-hiv-positive-patients-treated-with-antiretroviral-medications
#7
Sina Moradmand Badie, Mehrnaz Rasoulinejad, Mohammadreza Salehi, Hamid Emadi Kochak, SeyedAhmad SeyedAlinaghi, Seyed Ali Dehghan Manshadi, Fatemeh Jahanjo Amin Abad, Banafsheh Moradmand Badie
BACKGROUND: Echocardiography is a reliable means for the diagnosis of functional and valvular diseases of the heart in HIV positive and HIV negative patients. The current study was to evaluate echocardiographic abnormalities in HIV positive patients under an antiretroviral therapy (ART) program in Tehran, Imam Khomeini Hospital, Iran. METHODS: This is a descriptive cross-sectional study, conducted among 231 HIV positive patients under ART. All HIV positive patients including 150 men (65%) and 81 women (35%) (mean age of 41 years) were assessed by trans-thoracic echocardiography (TTE) in Imam Khomeini Hospital, over the period from 2013 to 2014...
December 5, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27915986/molecular-analysis-of-pseudomonas-aeruginosa-metallo-beta-lactamase-a-first-report-of-an-iranian-referral-pediatric-hospital
#8
Shima Mahmoudi, Babak Pourakbari, Mansoure Hosseini, Amir Esmaeil Alyari, Mohammad Taghi Haghi Ashtiani, Setareh Mamishi
INTRODUCTION: Pseudomonas aerouginosa is an important opportunistic pathogen causes clinical infections among ill patients. Metallo- Beta- lactamases (MBLs) are important mechanisms of carbapenem (drug of choice) resistance among Pseudomonas aerouginosa isolates. The aim of this study was to determine B- lactamases genes (bla-genes) in P. aerouginosa isolates and to detect percentage of MBLs among P. aerouginosa isolates in different wards. MATERIAL AND METHODS: Clinical isolates of P...
December 2, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27889997/acute-cystitis-caused-by-commensal-neisseria-oralis-a-case-report-and-review-of-the-literature
#9
Yassar Alamri, Aaron Keene, Alan Pithie
Neisseria are usually harmless inhabitants of otherwise asymptomatic persons' upper respiratory mucosal surfaces. It is, therefore, expected that a disturbance in the physiology leads to non-gonococcal, non-meningococcal Neisseria becoming pathogenic. We report the case of a diabetic man who initially presented with non-specific symptoms and was later found to have cystitis caused by N. oralis. We also review the pertinent literature and discuss available evidence on pathophysiological mechanisms of infection with such commensal bacteria...
November 23, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27875955/detection-the-mycoplasma-pneumonia-in-synovial-fluid-of-children-with-negative-culture-arthritis-a-cross-sectional-study-in-tehran-iran
#10
Samileh Noorbakhsh, Mohammad Reza Shokrollahi, Farideh Ebrahimi Taj, Vida Zarabi, Azardokht Tabatabaei
BACKGROUND: arthritis could be caused by different etiologies ranging from rheumatologic diseases to infectious conditions. Therefore, early diagnosis of etiology and treatment is important. The purpose of this study was to determine the the M.pneumonia in synovial fluid of children with arthritis by 2 methods (serology and qualitative PCR). Methods & materials: this trial was carried out as a cross sectional study in pediatric and orthopedic ward of Rasoul-e Akram hospital in Tehran, Iran...
November 21, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27848902/the-impact-of-mass-gathering-on-the-burden-of-multidrug-resistant-mycobacterium-tuberculosis-in-al-madinah-al-monawarah-region-saudi-arabia
#11
Mogahid Elhassan, Hassan A Hemeg, Miskelyemen A Elmekki, Khalid A Turkistani, Ahmed A Abdul-Aziz
BACKGROUND: The pattern of Mycobacterium tuberculosis susceptibility to first line drugs and multidrug resistance in Al-Madinah Al-Munawarah, a seasonally overcrowded are during Hajj and Omrah, is not well studied. OBJECTIVE: This study aimed to investigate anti-TB drug resistance and its distribution among new cases in Al-Madinah Al-Monawarah. METHODS: Study subjects included 622 patients with first time confirmed TB referred to the central tuberculosis laboratory in Al-Madinah between January 2012 and December 2014...
November 15, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27829328/use-of-oritavancin-novel-new-lipoglycopeptide-in-the-treatment-of-prosthetic-joint-infections-pji-a-possible-alternative-novel-approach-to-a-difficult-problem
#12
Suresh Jude Antony, Leigh G Cooper
Prosthetic joint infections (PJI) result in significant morbidity, mortality and cost to patients and the health system. Traditional treatment involves a two-staged revision and occasionally a single staged revision along with intravenous antibiotics (IV) and or oral antibiotics for several weeks to months. The use of a single staged revision along with an antibiotic which has a prolonged half life and is bactericidal would be ideal. We present 2 patients who were treated successfully with a single stage revision/antibiotic spacer and a new novel long acting lipoglycopeptide called oritavancin...
November 8, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27784234/use-of-intra-articular-amphotericin-b-in-the-treatment-of-candida-parasilosis-and-albicans-in-prosthetic-joint-infections-pji-a-novel-approach-to-this-difficult-problem
#13
Suresh Jude Antony
Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years. This method has several advantages including: lack of systemic toxicity, ease of administration, and potentially better cure rates. The treatment of fungal infections in prosthetic joint arthroplasties is problematic with high failure and recurrence rates. We present 2 patients with Candida parasilosis and Candida albicans infections within the arthroplasty that were successfully treated with a single stage revision/spacer placement in conjunction with the use of intra-articular amphotericin B...
October 26, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27774886/the-clinico-hematological-features-and-management-outcome-in-neonatal-malaria-a-nine-years-analysis-from-north-india
#14
Kriti Mohan
BACKGROUND: Malaria is an important cause of death and illness in children worldwide. Most cases of neonatal malaria are misdiagnosed because of the lack of specific symptoms and a general lack of awareness. Nothing much is known in literature about the haematological changes during malaria infection and outcome of disease in neonates. Neonatal malaria is an underdiagnosed entity. So this hospital based observational study aims to assess diagnostic features of neonatal malaria. METHODS: From August 2004 to August 2013, information of all slide positive for malaria cases aged 0 to 28 days admitted to our pediatric hospital was collected and analysed...
October 20, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27758685/consequence-of-maternal-zika-virus-infection-a-narrative-review
#15
Kamal Niaz, Mohammad Abdollahi
Zika virus (ZIKV) is a deadly flavivirus that has spread from Africa to Asia and European countries. The virus is associated with other viruses in the same genus or family, transmitted by the same mosquito species with known history of fatality. A sudden increase in the rate of infection from ZIKV has made it a global health concern, which necessitates close symptom monitoring, enhancing treatment options, and vaccine production. This paper reviewed current reports on birth defects associated with ZIKV, mode of transmission, body fluids containing the virus, diagnosis , possible preventive measures or treatments, and vaccine development...
October 18, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27658860/citrobacter-braakii-bacteremia-case-report-and-review-of-the-literature
#16
Michelle Oyeka, Suresh Antony
Bacteremia is usually caused by gram-positive organisms such as Staphylococcus aureus or β hemolytic streptococci. While there is a wealth of information that exits for these types of bacteremia, less is available to address bacteremia that is caused by less common bacteria such as Citrobacter. We report an unusual case of Citrobacter braakii bacteremia in a patient with multiple comorbidities that presented to the hospital with cellulitis and pleural effusion. Blood cultures grew Citrobacter braakii. Despite good response to antibiotic treatment, the patient's infection proved to be persistent and he succumbed to the cirrhosis of the liver and subsequent renal failure...
September 20, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27488498/the-status-of-methicillin-resistance-among-egyptian-staphylococcus-aureus-isolates-an-overview
#17
Alaa Abouelfetouh
Methicillin resistant Staphylococcus aureus (MRSA) is responsible for a large number of antibiotic resistant infections worldwide. Understanding the epidemiology and identifying the molecular characteristics of MRSA is elemental in designing infection control plans to minimize the risks associated with these infections. The prevalence of MRSA varies between the different geographic regions. In Egypt, such knowledge is sparse, with a limited number of isolated studies reporting the infection rate of MRSA in select parts of the country...
August 2, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27411472/use-of-intra-articular-antibiotics-along-with-single-stage-revision-to-treat-prosthetic-joint-infections-pji-orthopedic-related-devices-ord-suggestions-for-selection-of-the-appropriate-patients-for-this-procedure
#18
Suresh Antony
Use of intra-articular antibiotics has been used by some centers although not widely accepted by most orthopedic centers (1-4) In a study published by our group in June 2015 in patients who were treated with single stage exchange arthroplasty with intra-articular antibiotics, we noted that the majority of the patients treated with this modality did well. However, there was a subset of the patients that failed therapy as well. We decided to look at this group of patients and see if we could make constructive recommendations that would help clinicians select the right patients for this procedure so as to improve clinical outcomes...
July 13, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27411471/the-rapid-development-of-esbl-e-coli-resistance-to-ceftolozane-tazobactam-in-a-patient-with-a-liver-abscess-the-search-for-an-omnipotent-antibiotic-goes-on
#19
Mohamed Teleb, Enrique Soto-Ruiz, Delfina C Domínguez, Suresh Antony
Multi drug resistant (MDR) Pseudomonas aeruginosa and Extended-Spectrum-lactamase (ESBL) Enterobacteriaceae are becoming an increasing difficult clinical problem. Immediate resistance to some of the new antimicrobials such as ceftolozane/tazobactam is unusual and is due to a variety of mechanisms such as hy-per-production of inactivating enzymes and gene mutation. In addition, previous antimicrobial administration is a well-recognized risk factor to develop resistance. We present a patient with a liver abscess where the organism was resistant to ceftolozane/tazobactam resulting in a poor clinical outcome...
July 13, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/26767386/escherichia-fergusonnii-pathogen-in-urinary-tract-infection
#20
Seema Mittal, Meenal Gupta, Madhu Sharma, Uma Chaudhary
Urinary tract infections are one of the leading cause of morbidity in admitted patients. Most commonly caused by Escherichia coli, but there are some variants which are commonly reported in urinary tract infection. This study was about to speciate such isolate like E.fergusonnii and find out its antibiogram.
January 15, 2016: Infectious Disorders Drug Targets
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