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Infectious Disorders Drug Targets

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https://www.readbyqxmd.com/read/28758575/biological-activities-and-secondary-metabolite-screening-of-rumex-hastatus-extract-through-fourier-transform-infrared-and-raman-spectroscopy
#1
Saiqa Andleeb, Anum Naseer, Shaukat Ali, Rozina Ghulam Mustafa, Atiya Zafar, Irsa Shafique, Hsan-Ul-Haq, Muhammad Ismail, Muhammad Saleem, Qaiser Mansoor
BACKGROUND: Human infectious diseases began by various pathogens including bacteria, fungi, viruses, parasites, and protozoans. These infectious agents are controlled by using synthetic drugs as well as natural sources. AIM OF STUDY: Methods: In current research antibacterial effect of Rumex hastatus was analyzed against seven clinical pathogenic bacteria such as Escherichia coli, Serratia marcescens, Streptococcus pyogenes, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruiginosa through agar well diffusion method...
July 28, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28707597/detection-of-extended-spectrum-beta-lactamases-esbls-and-antibiotic-susceptibility-patterns-in-klebsiella-pneumoniae-in-western-iran
#2
Pegah Shakib, Rashid Ramazan Zadeh, Morovat Taherikalani, Bijan Nouri
BACKGROUND: Production of Beta-Lactamase enzymes, especially extended-spectrum Beta -Lactamases (ESBL), is a primary mechanism of resistance in these bacteria. The purpose of this study was detection of blaTEM, blaSHV, blaCTX-M, blaCTX-M-15, blaPER and blaVEB in K. pneumoniae, isolated from clinical specimens by the PCR method and antibiotic susceptibility patterns in these strains isolated, in Sanandaj city, Iran. MATERIALS AND METHODS: During a period from October 2015 to July 2016, 52 K...
July 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28707596/pseudomonas-aeruginosa-osteomyelitis-of-the-pubic-bone-a-case-report
#3
Raheleh Golrokhy, Saeed Jamali, Mehrnoosh Samaei, SeyedAhmad SeyedAlinaghi
Pubic osteomyelitis is a rare disease that typically occurs as a complication of various gynecologic and urologic surgeries. We present a 78 year old woman admitted to the Infectious Department of Imam Khomeini Hospital in June 2014 with pubic osteomyelitis caused by Pseudomonas aeruginosa followed by hysterectomy.
July 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28675995/ebola-epidemics-control-origin-and-therapeutics
#4
Da Yong Lu, Hong Ying Wu, Nagendra Sastry Yarla, Ting-Ren Lu, Bin Xu, Jian -Ding
Ebola epidemic in Africa was outbreak again in 2014 that arises a new wave of panic worldwide. There is a high mortality rates (30-70%) among Ebola infected people in virus-stricken areas. The direct communications between affected countries and rest of world were cut off then. But the medical capabilities against this deadly viral disease were provided by a limited number of agents, several patented agents, biotherapies or prophylactic/therapeutic vaccines have been entering into clinical validations and will be further developed into the global markets-including patents of small molecular chemicals, short sequences or oligomers of DNA/RNA, linkages of chemicals with bio-molecules, herbal medicine and so on...
July 3, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28637420/bioinformatics-insights-on-targets-receptors-of-amiodarone-in-human-and-acanthamoeba-castellanii
#5
Abdul Baig, Zohaib Rana, H R Ahmad
BACKGROUND: Amiodarone is prescribed for certain cardiac arrhythmias in medical practice. The drug targets and inhibits voltage dependent sodium (Na+v), calcium (Ca+2v), potassium (K+v) channels, and enzymes like cytochrome P450 and oxidosqualene cyclase. Past studies have shown that amiodarone exerts anti-amoebic effects against Trypanosoma cruzi and Acanthamoeba castellanii. OBJECTIVES: The presence of aforementioned targets and the type of cell death induced by amiodarone in these pathogenic eukaryotes like Acanthamoeba castellanii remain to be verified...
June 21, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28595543/alkaloids-and-leishmania-donovani-udp-galactopyarnose-mutase-anovel-approach-in-drug-designing-against-visceral-leishmaniasis
#6
Ankita Srivastava, Deepak Chandra
BACKGROUND: The unsatisfactory treatment options for Visceral Leishmaniasis (VL), needs identification of new drug targets. Among natural products, Alkaloids have been proved to be highly effective against number of diseases. In Leishmania UDP-galactopyranose mutase (UGM) is a critical enzyme required for cell wall synthesis and thus a drug target for structure based drug designing against L. donovani. OBJECTIVE: To build the homology model of UDP galactopyranse mutase and investigate the interaction of selected alkaloids with this modeled UDP galactopyranose mutase by molecular docking...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28595542/synthesis-of-99mtc-rifabutin-a-potential-tuberculosis-radiodiagnostic-agent
#7
Syed Qaiser Shah, Mamoona Alam
BACKGROUND: Rifabutin (RFN) is bactericidal antibiotic with a very broad spectrum of activity against gram positive & gram negative organisms including Pseudomonas aeruginosa and specifically Mycobacterium tuberculosis. OBJECTIVE: RFN inhibits DNA dependent RNA polymerase activity in susceptible cells. In the instant work, the therapeutic characteristics of RFN were intended for diagnostic rationale by labeling it with 99mTc (Technetium-99m). The 99mTc labeled RFN (99mTc-RFN) was investigated for labeling capacity, steadiness in saline & serum, in vitro Mycobacterium tuberculosis (MBT) uptake & distribution in MBT stained animal model rats...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28595541/evaluating-the-role-of-interleukin-12-b-gene-polymorphism-in-prediction-of-disease-progression-in-patients-with-chronic-hepatitis-c-virus-infection
#8
Nadia Elwan, Khalda Amr, Sahar Elyamany, Walaa Elkhalawany, Shaimaa Soliman, Mohamed Ziada, Sherief Abd-Elsalam
Background &Aims: Cell-mediated immunity plays a critical role in viral clearance and disease progression during Hepatitis C virus (HCV) infection. Interleukin (IL)-12 is a cytokine that has been shown to be a potent antiviral cytokine. The aim of this work is to investigate the association of IL-12 B gene polymorphism with the progression of liver disease in chronic HCV patients. METHODS: This cross sectional study was carried out in tropical medicine department, Tanta university hospital, Egypt, on 120 chronic HCV patients with various stages of liver disease and 30 healthy subjects served as control...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28595540/apicoplast-import-protein-tic20-a-promising-therapeutic-molecular-target-for-plasmodium-falciparum-an-insilico-approach-for-therapeutic-intervention
#9
Pavan C P K Srimath-Tirumala-Peddinti, Sandeep Solmon Kusuma, Deepthi Nammi, Nageswara Rao Reddy Neelapu
Malaria is a lethal disease causing mortality to over millions each year. Drug resistance in the malarial parasite encouraged to discover effective antimalarial drug targets and drugs. An objective of this current study is to identify drug targets for malarial parasite. Genes unique, non-homologous to humans and essential for parasite are identified using BLASTn by comparing genomes between parasite and host. Further open BLASTp was used to filter the targets specific to Plasmodium species and later were subjected to gene property analysis to identify 65 potential targets...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28595539/targeted-drug-delivery-systems-and-its-therapeutic-applications-in-cancer-and-related-immune-pathological-conditions
#10
Saifullah Afridi, Jamshed Iqbal, Fareeha Anwar
BACKGROUND: Earlier a century ago, Paul Ehrlich proposed an idea of a drug "magic bullet" that selectively eradicate diseased cells without harming the surrounding normal cells. OBJECTIVE: Since a lot of progress has been attained in this field to discover new horizons for targeted delivery of drug. As major problem in disease therapy is the severe toxic effects of prescribed drugs on healthy cells. In order to reduce the adverse effects of chemotherapy on healthy tissues, herein, we summaries the use of recent drug delivery systems for targeted therapy...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28558644/a-case-of-subcutaneous-phaeohyphomycosis-associated-with-leprosy
#11
Márcia M R Teixeira, Claudia B Assunção, Renata R Gomes, Fabiana Rocha-Silva, Sônia M de Figueiredo, Elen R R Teixeira, Adriana S Carneiro, Rogério J M B Júnior, Vânia Vicente, Rachel Basques Caligiorne
Subcutaneous phaeohyphomycosis is a form of infection caused by dematiaceous fungi and frequently reported in the literature. It is considered as an emerging mycosis because it is increasingly reported among immunosuppressive patients. The most commonly cited etiologic agent is Exophiala jeanselmei, followed by Alternaria spp. We present a case of a 48-year-old woman, with a history of lepromatous leprosy, using corticosteroid in immunosuppressive doses due to a type 2 repetitive reaction leprosy outbreak, revealing subcutaneous phaeohyphomycosis lesions...
May 30, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28558643/expression-of-major-efflux-pumps-in-fluconazole-resistant-candida-albicans
#12
Babak Pourakbari, Mostafa Teymuri, Shima Mahmoudi, Sepideh Keshavarz Valian, Zahra Movahedi, Hamid Eshaghi, Setareh Mamishi
INTRODUCTION: Resistance to azole antifungals continues to be a significant problem in Candida albicans infections. Several molecular mechanisms of fluconazole resistance including alterations in the gene encoding the target enzyme ERG11 or overexpression of efflux pump genes including CDR1, CDR2, MDR1, MDR2 and FLU1 have been reported. The aim of this study was to investigate molecular mechanisms of fluconazole- resistant C. albicans. MATERIAL AND METHODS: In the present study, a collection of 97 clinical isolates of C...
May 30, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28558642/the-novel-strategy-in-combat-with-breast-cancer-ex-vivo-evalu-ation-of-traditionally-used-berberis-vulgaris
#13
Mina Mahmoodi, Mahsa Jalili, Zahra Chavak, Nasrin Valizadeh, Nourkhoda Sadeghifard, Iraj Pakzad, Marayam Mohammadian, Mehrnoush Safikhanimoslem, Abbas Maleki, Sobhan Ghafourian
Pseudomonas aeruginosa is responsible for many infections and also many antibiotic resistance genes existed in this bacterium. Some focused to toxin antitoxin systems demonstrated these systems as regulon of this properties of P. aeruginosa. Therefore, in an analysis we tried to evaluate the potent TA loci and suggest some of them for experimental analysis. For this reasons, RASTA databases were subjected and our results demonstrated hth-xre as dominant known and many unknown TA loci. Despite of distribution of TA loci in all scores but obtained results of hth-xre TA loci suggested these unknown TA loci may be helpful for further both bioinformatics and experimental analysis...
May 30, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28521672/revision-and-implementation-of-clinical-guideline-for-tuberculosis-and-hiv-in-prisons-great-tehran-prison-iran
#14
Behnam Farhoudi, SeyedAhmad SeyedAlinaghi, Minoo Mohraz, Raheleh Golrokhy, Marzieh Farnia, Mohammad Shahbazi, Ramin Alasvand, Bahman Ebrahimi, Jafar Esfehani, Mehrzad Tashakoriyan
AIM: To evaluate the feasibility of the revised "Clinical Guideline for HIV and TB" in the Great Tehran Prison during October 2013 to June 2014. METHODS: The guideline includes all aspects of HIV/TB diagnosis based on active case finding (ACF), treatment and care services. Before the implementation, a focus group discussion was conducted, and attended by experts on jail diseases. The objective was to identify defects and limitations of the guideline. After the discussion, the guideline was revised...
May 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28474549/haart-in-hiv-aids-treatments-future-trends
#15
Da Yong Lu, Nagendra Sastry Yarla, Bin Xu, Jian Ding, Ting-Ren Lu, Hong Ying Wu
AIDS (acquired immune deficient syndrome) is a deadly human viral infectious disease caused by HIV (human immune-deficient virus) infection. Almost every AIDS patient losses his/her life before mid 1990s. AIDS was once the 1st disease killer in US (1993). After one decade hard work, antiviral drug cocktails-high active anti-retroviral therapy (HAART) have been invented for almost all HIV infection treatments. Due to the invention of HAART, 80-90% HIV/AIDS patients still effectively response to HAART for deadly AIDS episode controls and life saving...
May 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28474548/resolution-of-chest-x-ray-opacities-in-patients-with-ventilator-associated-pneumonia
#16
Shervin Shokouhi, Ilad Alavi Darazam, Raziyeh Niyati, Latif Gachkar, Reza Goharani, Shahram Kahkoue
BACKGROUND: Chest Radiograph accompanied by clinical and laboratory findings are required for diagnosis and follow-up of patients with suspected ventilator-associated pneumonia (VAP). However, there are no reliable data whether follow-up chest-X-ray (CXR) is needed or not, moreover, when the physicians request CXR and how many times CXR is required. We aimed to determine association of the clinical improvement with resolution of pulmonary infiltrates as well as time of resolution. MATERIALS AND METHODS: The patients with a diagnosis of VAP based on Clinical Pulmonary Infection Score (CPIS) were enrolled in this study...
May 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28464777/the-endocytic-transport-as-a-drug-target-in-infectious-diseases
#17
Amandio Vieira, Shaun P Wong
Components of the extracellular environment can be transported into cells by molecular mechanisms collectively termed endocytosis. Cells typically use a multitude of different internalization pathways. These endocytic transport pathways have a wide range of implications for physiological regulation as well as pathological processes. Many infectious diseases, for example, involve internalization of the pathogen into the cell as part of the infection process. Selective interference with the endocytic transport of a microbe, thus, represents a therapeutic strategy that may prevent infections or decrease the rate of their progression...
May 2, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28464776/gastric-mucosal-oxidative-stress-markers-in-children-with-helicobacter-pylori-infection
#18
Adel Abd Elhaleim Hagag, Saleh M Amin, Mohammed H Emara, Sally E Abo-Resha
BACKGROUND: 'Helicobacter pylori' "H. pylori" is one of the most common infections that colonizes human gastric mucosa and generates reactive oxygen and nitrogen species. The aim of this study was to evaluate the oxidative stress markers in the gastric mucosa of "H. pylori"- infected children. PATIENTS AND METHODS: The present study was carried out on 60 children infected with "H. pylori" including 28 males, 32 females with their age ranging from 7-10 years and mean age value of 8...
May 2, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28462698/evaluation-of-salivary-uric-acid-and-ph-in-human-immunodeficiency-virus-infected-patients-a-historical-cohort-study
#19
Fatemeh Ahmadi-Motamayel, Samaneh Vaziri-Amjad, Mohammad Taghi Goodarzi, Jalal Poorolajal
OBJECTIVE: Antioxidants protect body against cellular damage .Saliva has immunological, enzymatic and antioxidant defense systems. Uric acid is the main and predominant salivary antioxidants molecules. The aim of this study was evaluation of salivary uric acid and pH in HIV infected patients in west of Iran. METHODS: HIV infected patients were selected from behavioral advisory centers of Hamadan and Kermanshah provinces, west of Iran. Saliva was collected between 8 to10 at morning...
April 28, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28460614/the-prevalence-of-pila-and-algd-virulence-genes-in-pseudomonas-aeruginosa-urinary-tract-and-tracheal-isolates
#20
Hassan Valadbeigi, Nourkhoda Sadeghifard, Majid Baseri Salehi
P. aeruginosa is one of the bacteria opportunistic that played main role in pathogenicity of patient in urinary tract infection (UTI) and respiratory tract infections. So, the aim of this study was to evaluate the prevalence of virulence genes including algD and pilA among Pseudomonas aeruginosa in urinary tract infection and tracheal isolates. After DNA extraction of clinical isolates, polymerase chain reaction was performed, and the results highlighted algD in all isolates, while pilA was dominant in tracheal isolates...
April 27, 2017: Infectious Disorders Drug Targets
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