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Endocrine, Metabolic & Immune Disorders Drug Targets

Franca Dicuonzo, Stefano Purciariello, Aurora De Marco, Edoardo Guastamacchia, Vicenzo Triggiani
BACKGROUND AND OBJECTIVE: giant pituitary adenomas (GPAs) are benign tumours with a diameter ≥ 4 cm [1]. They can cause symptoms and signs due to the possible hyper-secretion of one or more pituitary hormones, and involvement of the surrounding structures whereas the compression of the pituitary itself can lead to hypopituitarism. METHODS: we report on a young woman with acromegaly due to an inoperable giant GH-secreting pituitary adenoma extending to right cavernous sinus, right orbital cavity, ethmoid, right maxillary sinus, sphenoid sinus, clivus and right temporal fossa, in which medical treatment with Octreotide-LAR was able to promptly relieve headache and bilateral hemianopsia due to optic chiasm involvement, improve acromegaly symptoms and, over the time, control tumor expansion, improving fertility and therefore allowing the patient to become pregnant...
August 7, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Elsaid Wasfy, Galal Elkassas, Sally Elnawasany, Kariman Elkasrawy, Sherief Abd-Elsalam, Shaimaa Soliman, Rehab Badawi
Background& Aims: Esophageal varices (EV) are a major complication of portal hypertension in cirrhotic patients. Screening is essential for all patients with cirrhosis. Performing non-invasive methods for screening is a cost-effective and time-saving measure. The aim of this work is to evaluate whether insulin resistance (IR) assessed by HOMA-IR score can predict the presence of EV or not. METHODS: This cross-sectional study was carried out on sixty Egyptian cirrhotic HCV patients divided into 3 groups: Group I: 20 cirrhotic patients without esophageal varices, Group II: 20 cirrhotic patients, with small esophageal varices and Group III: 20 cirrhotic patients with large esophageal varices...
August 3, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Anoop Kumar, Ruchika Sharma, Divya Rana, Neelima Sharma
BACKGROUND AND OBJECTIVE: α-Tocopherol is the active form of vitamin E which have various biological functions. However, the exact molecular mechanism of its action is not fully understood. Thus, the main objective of the current study is to determine the contribution of α-tocopherol in counteraction of the apoptogenic signaling pathways induced by deltamethrin in murine thymocytes and splenocytes. METHODS AND RESULTS: Deltamethrin (25 µM) induces apoptosis at 18 h through activation of reactive oxygen species, caspases and depletion of glutathione in thymocytes and splenocytes...
August 1, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Luis Raposo, Sandra Martins, Daniela Ferreira, Joao Tiago Guimaraes, Ana Cristina Santos
Background The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, the national prevalence of the metabolic syndrome remains high. The association of thyroid pathology with cardiovascular risk has been addressed but is still unclear. Our study aimed to evaluate the prevalence of thyroid dysfunction and autoimmunity and to assess the associations of thyroid-stimulating hormone and thyroid hormones and antibodies with metabolic syndrome, its components, and other possible determinants in a national sample...
August 1, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Miriana Rosaria Petrera, Marilina Tampoia, Stefania Guida, Letizia Abbracciavento, Ruggiero Fumarulo, Caterina Foti
BACKGROUND: The association of bullous pemphigoid (BP) and neurologic disease (ND) has been proven. OBJECTIVE: To investigate the presence of specific markers for the association between BP and ND. METHOD: A total of 47 patients with PB, at the onset of the disease, were retrospectively recruited from January 2015 to October 2017 in a single center (Dermatology Unit, University of Bari "Aldo Moro", Bari, Italy). RESULTS: We have found an association between BP, ND and specific serologic profile characterized by higher levels of anti-BP180 and anti-BP230 (t(45)=2...
July 30, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Alessandro Borghi, Monica Corazza, Elisa Maietti, Cataldo Patruno, Maddalena Napolitano, Donatella Schena, Maria Letizia Musumeci, Giuseppe Micali, Paolo Romita, Caterina Foti
BACKGROUND: due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and the nickel contained in make-ups remains controversial. OBJECTIVE: to assess the association between nickel allergy, the use of pigmented make-up products and self-reported eyelid dermatitis. METHOD: this multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls)...
July 30, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Vasiliki Sideri, George Antonakos, Andreas Fretzayas, Achilleas Attilakos, Charalambos Chrelias, Vasiliki Papaevangelou, Polyxeni Nicolaidou, Anna Papadopoulou
BACKGROUND/OBJECTIVES: The aim of this work was to evaluate the current vitamin D status in healthy pregnant women and their newborns living in Greece and assess possible associations between 25(OH)D and anthropometric features of their fetuses and newborns. MATERIALS & METHODS: 81 healthy women were monitored during pregnancy. Biochemical markers related to bone metabolism, 25(OH)D and PTH levels were measured in serum samples of mother-newborn pairs at 1st trimester of pregnancy and at delivery in mothers, in cord blood and at the 3rd day of life of newborns...
July 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Maria Isabel Martinez-Martinez, Antoni Alegre-Martinez, Jessica Garcia-Ibanez, Omar Cauli
BACKGROUND AND OBJECTIVE: Coeliac disease (CD) is a chronic autoimmune intestinal disorder characterized by intolerance to gluten, a protein contained in certain cereals. The main physiopathological basis of CD is the progressive destruction of intestinal villi caused by gluten ingestion by genetically-susceptible individuals. Patients who receive a diagnosis of CD must make significant changes to their daily habits and this can affect their quality of life. The objective of this review is to summarize the evidence regarding the economic, physical and social limitations which can affect quality of life in patients with CD...
July 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Ghada Abdelmoemen, Samy Abdelkader Khodeir, Ahmed Nabil Zaki, Maha Kassab, Sabry Abou-Saif, Sherief Abd-Elsalam
BACKGROUND & AIMS: Insulin resistance is the real determinant of both Nonalcoholic fatty liver disease (NAFLD) and diabetes, and can facilitate the accumulation of triglycerides in the liver. Overexpression of hepassocin (HPS) increased the accumulation of hepatic fat and NAFLD activity scores (NAS) in mice. The aim of this study was to investigate the relationship between hepassocin and steatosis of the liver in diabetic patients with or without NAFLD in humans. METHODS: The study enrolled 60 patients plus 20 healthy controls that were divided into 4 groups: Group I: included 20 patients who were diagnosed as diabetes mellitus type 2, Group II: included 20 patients who were diagnosed as nonalcoholic fatty liver disease (NAFLD), Group III: included 20 patients who were diagnosed as diabetes type 2 and NAFLD, and Group IV (control group): included 20 healthy person or controls who were matched in age and sex with patients group...
July 15, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Vito Angelo Giagulli, Beatrice Capone, Marco Castellana, Ciro Salzano, Alessandra Fisher, Cristina de Angelis, Rosario Pivonello, Annamaria Colao, Daniela Pasquali, Mario Maggi, Vincenzo Triggiani
BACKGROUND AND OBJECTIVE: Klinefelter Syndrome (KS) is the most common sex chromosome aneuploidy (47,XXY) and cause of male hypergonadotropic hypogonadism. It is characterized by an extreme clinical heterogeneity in presentation, including infertility, hypogonadism, language delay, metabolic comorbidities, and neurocognitive and psychiatric disorders. Since testosterone is known to have organizational, neurotrophic and neuroprotective effects on brain, the condition of primary hypogonadism could play a role...
July 3, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Hitesh Verma, Rajeev Garg
BACKGROUND: Multiple cross sectional and longitudinal studies reported the benefits of vitamin K intake for management of cardiometabolic risk factors so as to minimize the risk of cardiovascular diseases. OBJECTIVE: In present systematic review and meta-analysis, we aimed to evaluate the effect of vitamin K supplementation on cardiometabolic risk factors. METHODOLOGY: A systematic literature search of PubMed, Cochrane central, Clinicaltrials...
July 3, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Carlos A Canas, Fabio Bonilla-Abadia, Katherine Vallejo, Hector M Rengifo, Marco A Gallon, Gabriel J Tobon
BACKGROUND AND OBJECTIVE: Thyroid-associated ophthalmopathy (TAO) is the most common extrathyroidal manifestation of Graves disease, occasionally severe and refractory to treatment, mainly in long-term disease. In these cases, one of the most important infiltrating cytokines in the orbital tissue is interleukin-6 (IL-6). METHODS: This is a case report, the methodology consisted in the application of tocilizumab in a patient with graves disease and the patient's follow-up...
July 2, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Marina Ruxandra Otelea, Agripina Rascu
BACKGROUND: Occupational asthma occurs in a significant number of adult unset forms of asthma. Even after exposure cessation, persistent asthma is frequent. Although recognized as important, nutrition, and specifically vitamin D intake, was rarely evaluated in occupational asthma. OBJECTIVE: To assess the vitamin D intake in occupational asthma patients and the relation with body mass index, co-morbidities related to vitamin D deficit, lung function and quality of life...
June 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Ana Sofia Figueiredo, Patricia Andrea-Ferreira
BACKGROUND AND OBJECTIVE: Anaplastic thyroid carcinoma is rare, but represents the deadliest type of thyroid cancer that is characterised by a rapid course. Diagnosis is usually made at a late stage, when more than half of the patients have distant metastasis. Our main purpose is to review the current information on anaplastic thyroid aetiology and risk factors that might contribute to an earlier diagnosis as well as to give new perspectives regarding the most recent treatment options and future directions...
June 10, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Adel A Hagag, Ibrahim M Badraia, Mohamed M Abdelmageed, Nahed M Hablas, Sahar Me Hazzaa, Nahla A Nosair
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the commonest childhood cancer. Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells. AIM OF THE WORK: To assess the prognostic value of Transferrin receptor -1 (CD71) in children with newly diagnosed ALL...
June 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Giovanni Gravina, Walter Milano, Grazia Nebbiai, Carla Piccione, Anna Capasso
BACKGROUND AND OBJECTIVE: Anorexia Nervosa (AN), Bulimia Nervosa (BN) and their variants are characterized by persistent alteration of eating behaviour, such as restricted intake or bingeing and purging, as well as excessive concerns about body shape and body weight. Purging behaviour may include self induced vomiting and/or abuse of laxatives, diuretics and physical hyperactivity. Unlike other psychiatric disorders, patients suffering from AN and BN have a high prevalence of many different medical complications, through the sequelae of undernutrition and purging, often with a serious impairment of health status and quality of life...
May 30, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Franco Grimaldi, Fabio Vescini, Veronica Tonelli, Cinzia Pistis, Elda Kara, Vincenzo Triggiani, Elio Tonutti, Francesco Curcio, Martina Fabris
BACKGROUND AND OBJECTIVE: BLyS (B-Lymphocyte stimulator) is over-expressed in several tumoral settings, with direct or indirect effects on neoplastic proliferation and possibly representing a therapeutic target. In this study we explored the role of BLyS in a large population of patients with neuroendocrine tumors (NETs). METHODS: The study analyzed the stored sera of 124 consecutive unselected patients with NETs: 36 lung carcinoids (24 typical, 12 atypical), 47 gastroenteric tract and 41 pancreatic (30 non-functioning and 11 functioning: 9 insulinomas, 2 glucagonomas)...
May 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Hina Rashid, Shikha Sharma, Saba Beigh, Firoz Ahmad, Sheikh Raisuddin
INTRODUCTION: Bisphenol A (BPA) is suspected to cause hormonal imbalance in humans. Dietary factors are known to bring changes in hormonal profile. In order to study chemico-biological interaction of iron deficiency on toxicity outcome of BPA exposure, we studied the modulatory effects of iron deficiency on the hormone levels in rats chronically-exposed to BPA. METHODS: Weanling rats maintained on normal and iron-deficient diets were exposed to low level of BPA at 0, 1, 5 and 10 ppm for six months through drinking water...
May 20, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Omar Farid, A El Haidani, Mohamed Eddouks
In this work the effect of Mentha spicata (L.) (M. spicata) aerial part aqueous extract (A.P.A.E) at a dose of 20 mg/kg body weight on blood glucose levels has been demonstrated in normal and streptozotocin (STZ) diabetic rats. Additionally, a preliminary phytochemical screening for various bioactive constituents was realized and a dosage of polyphenols and flavonoid has been done. Moreover, the histopathological changes in liver and pancreas have been evaluated both in normal and STZ diabetic rats. The effect of M...
May 16, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Fereshteh Rasa, Nadereh Naderi, Ebrahim Eftekhar, Elahe Mansoori, Mahsa Rahimzadeh
BACKGROUND: The exact mechanisms underlying the protective effect of vitamin D in the pathogenesis of atherosclerosis and coronary heart disease is obscure. OBJECTIVE: Here, we have addressed the relation between vitamin D status and regulatory T cells (Tregs) inhibitory cytokines in patients suffering from coronary artery disease (CAD). MATERIALS AND METHODS: 81 patients were divided into single (n= 20), double (n=20) and triple (n=20) vessel disease groups and compared to no vessel disease (No VD) group (n=21)...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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