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Endocrine, Metabolic & Immune Disorders Drug Targets

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https://www.readbyqxmd.com/read/29886838/new-perspectives-regarding-anaplastic-thyroid-carcinoma-approach-improvement
#1
Ana Sofia Figueiredo, Patricia Andrea-Ferreira
BACKGROUND AND OBJECTIVE: Anaplastic thyroid carcinoma is rare, but represents the deadliest type of thyroid cancer that is characterised by a rapid course. Diagnosis is usually made at a late stage, when more than half of the patients have distant metastasis. Our main purpose is to review the current information on anaplastic thyroid aetiology and risk factors that might contribute to an earlier diagnosis as well as to give new perspectives regarding the most recent treatment options and future directions...
June 10, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29875008/prognostic-value-of-transferrin-receptor-1-cd71-expression-in-acute-lymphoblastic-leukemia
#2
Adel A Hagag, Ibrahim M Badraia, Mohamed M Abdelmageed, Nahed M Hablas, Sahar Me Hazzaa, Nahla A Nosair
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the commonest childhood cancer. Transferrin receptor 1 (CD71) is a trans-membrane glycoprotein which has important role in iron homeostasis by acting as a gatekeeper regulating iron uptake from transferrin and is an attractive target for anti-cancer agents, particularly those that aim to induce lethal iron deprivation in malignant hematopoietic cells. AIM OF THE WORK: To assess the prognostic value of Transferrin receptor -1 (CD71) in children with newly diagnosed ALL...
June 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29848283/medical-complications-in-anorexia-and-bulimia-nervosa
#3
Giovanni Gravina, Walter Milano, Grazia Nebbiai, Carla Piccione, Anna Capasso
BACKGROUND AND OBJECTIVE: Anorexia Nervosa (AN), Bulimia Nervosa (BN) and their variants are characterized by persistent alteration of eating behaviour, such as restricted intake or bingeing and purging, as well as excessive concerns about body shape and body weight. Purging behaviour may include self induced vomiting and/or abuse of laxatives, diuretics and physical hyperactivity. Unlike other psychiatric disorders, patients suffering from AN and BN have a high prevalence of many different medical complications, through the sequelae of undernutrition and purging, often with a serious impairment of health status and quality of life...
May 30, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29807524/exploring-the-possible-prognostic-role-of-b-lymphocyte-stimulator-blys-in-a-large-series-of-patients-with-neuroendocrine-tumors
#4
Franco Grimaldi, Fabio Vescini, Veronica Tonelli, Cinzia Pistis, Elda Kara, Vincenzo Triggiani, Elio Tonutti, Francesco Curcio, Martina Fabris
BACKGROUND AND OBJECTIVE: BLyS (B-Lymphocyte stimulator) is over-expressed in several tumoral settings, with direct or indirect effects on neoplastic proliferation and possibly representing a therapeutic target. In this study we explored the role of BLyS in a large population of patients with neuroendocrine tumors (NETs). METHODS: The study analyzed the stored sera of 124 consecutive unselected patients with NETs: 36 lung carcinoids (24 typical, 12 atypical), 47 gastroenteric tract and 41 pancreatic (30 non-functioning and 11 functioning: 9 insulinomas, 2 glucagonomas)...
May 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29779488/bisphenol-a-induced-endocrinotoxicity-and-male-reprotoxicopathy-is-modulated-by-the-dietary-iron-deficiency
#5
Hina Rashid, Shikha Sharma, Saba Beigh, Firoz Ahmad, Sheikh Raisuddin
INTRODUCTION: Bisphenol A (BPA) is suspected to cause hormonal imbalance in humans. Dietary factors are known to bring changes in hormonal profile. In order to study chemico-biological interaction of iron deficiency on toxicity outcome of BPA exposure, we studied the modulatory effects of iron deficiency on the hormone levels in rats chronically-exposed to BPA. METHODS: Weanling rats maintained on normal and iron-deficient diets were exposed to low level of BPA at 0, 1, 5 and 10 ppm for six months through drinking water...
May 20, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29769013/antidiabetic-effect-of-spearmint-in-streptozotocin-induced-diabetic-rats
#6
Omar Farid, A El Haidani, Mohamed Eddouks
In this work the effect of Mentha spicata (L.) (M. spicata) aerial part aqueous extract (A.P.A.E) at a dose of 20 mg/kg body weight on blood glucose levels has been demonstrated in normal and streptozotocin (STZ) diabetic rats. Additionally, a preliminary phytochemical screening for various bioactive constituents was realized and a dosage of polyphenols and flavonoid has been done. Moreover, the histopathological changes in liver and pancreas have been evaluated both in normal and STZ diabetic rats. The effect of M...
May 16, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29701163/vitamin-d-status-in-coronary-artery-disease-association-with-il-35-and-tgf-%C3%AE-1-and-disease-severity
#7
Fereshteh Rasa, Nadereh Naderi, Ebrahim Eftekhar, Elahe Mansoori, Mahsa Rahimzadeh
BACKGROUND: The exact mechanisms underlying the protective effect of vitamin D in the pathogenesis of atherosclerosis and coronary heart disease is obscure. OBJECTIVE: Here, we have addressed the relation between vitamin D status and regulatory T cells (Tregs) inhibitory cytokines in patients suffering from coronary artery disease (CAD). MATERIALS AND METHODS: 81 patients were divided into single (n= 20), double (n=20) and triple (n=20) vessel disease groups and compared to no vessel disease (No VD) group (n=21)...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29701162/hydrogen-sulfide-in-diabetic-complications-focus-on-molecular-mechanisms
#8
Ling-Ling Qian, Xiao-Yu Liu, Qiang Chai, Ru-Xing Wang
BACKGROUND: A growing number of studies have indicated that hydrogen sulfide (H2S) affects the development of diabetes and its complications, but the specific mechanism is not completely clear. OBJECTIVE: To summarize the effects and recent molecular mechanisms of H2S in various diabetic complications. METHODS: Articles regarding the role of H2S channels in diabetic complications and relevant mechanisms were selected. Relevant articles published from 2006 to present were selected from PubMed...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29697035/serum-n-terminal-pro-brain-natriuretic-peptide-level-is-associated-with-the-development-of-chronic-kidney-diseases-in-patients-with-type-2-diabetes
#9
Ryo Sawada, Yoshitaka Hashimoto, Takafumi Senmaru, Muhei Tanaka, Emi Ushigome, Masahiro Yamazaki, Michiaki Fukui
BACKGROUND AND OBJECTIVE: Previous studies revealed the association between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level and chronic kidney diseases (CKD) in general population. However, little is known about the association between serum NT-proBNP level and incident CKD in patients with type 2 diabetes. Thus, we investigated the impact of serum NT-proBNP level on incident CKD in patients with type 2 diabetes. METHOD: We enrolled 211 type 2 diabetic patients without CKD in this cohort study...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#10
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29683099/identifying-potential-therapeutics-for-osteoporosis-by-exploiting-the-relationship-between-mevalonate-pathway-and-bone-metabolism
#11
Wan Nuraini Wan Hasan, Kok-Yong Chin, James Jam Jolly, Norzana Abd Ghafar, Ima Nirwana Soelaiman
BACKGROUND: Osteoporosis is a silent skeletal disease characterized by low bone mass and destruction of skeletal microarchitecture, leading to an increased fracture risk. This occurs due to an imbalance in bone remodelling, whereby the rate of bone resorption is greater than bone formation. Mevalonate pathway, previously known to involve in cholesterol synthesis, is an important regulatory pathway for bone remodelling. OBJECTIVE: This review aimed to provide an overview of the relationship between mevalonate pathway and bone metabolism, as well as agents which act through this pathway to achieve their therapeutic potential...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29692271/menopause-does-not-affect-fatty-liver-severity-in-women-a-population-study-in-a-mediterranean-area
#12
Nicola Veronese, Maria Notarnicola, Alberto Osella, Anna Maria Cisternino, Rosa Reddavide, Rosa Inguaggiato, Vito Guerra, Ornella Rotolo, Iris Zinzi, Marisa Chiloiro, Gioacchino Leandro, Mario Correale, Valeria Tutino, Giovanni Misciagna, Caterina Bonfiglio, Gabriella Caruso
Estrogens could protect the liver from fatty degeneration, but there is little information about whether menopause is associated with the severity of alcoholic (AFL) and non-alcoholic fatty liver (NAFL). Our aim was to evaluate the distribution of fatty liver detected by ultrasound in pre- and post-menopausal women, as well as the factors associated with these conditions. In this cross-sectional study, the years from menopause were investigated through self-reported information. The degree of fatty liver was assessed through a standardized ultrasound examination (scores 0 to 6, higher values reflecting a greater severity)...
April 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29692270/recent-advances-in-endocrine-metabolic-and-immune-disorders-mesenchymal-stem-cells-mscs-and-engineered-scaffolds
#13
Stefania Cantore, Vito Crincoli, Antonio Boccaccio, Antonio Emmanuele Uva, Michele Fiorentino, Giuseppe Monno, Patrizio Bollero, Chiara Derla, Francesca Fabiano, Andrea Ballini, Luigi Santacroce
BACKGROUND: New sources of stem cells in adult organisms are constantly emerging. Postnatal Mesenchymal Stem Cells (MSCs), are the most promising support to perform an effective regenerative medicine: such cells have the ability to differentiate into several lineages, such as osteoblasts and chondroblasts, providing novel strategies to improve different complex treatments, during bone regeneration. 3D-printed biomaterials can be designed with geometry aimed to induce stem cells to differentiate towards specific lineage...
April 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29667557/modification-of-sexual-hormones-in-rheumatoid-arthritis-patients-by-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-nsaid-with-immunosuppressive-property
#14
Mozhgan Jahanbakhshi, Zohreh Babaloo, Seyed Shahabeddin Mortazavi-Jahromi, Maryam Monsef Shokri, Hossein Ahmadi, Abbas Mirshafiey
BACKGROUND: Based on in-vitro, in-vivo and human studies, the β-D-mannuronic acid (M2000) has been introduced as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties. OBJECTIVE: This study aimed to evaluate the efficacy of this drug on serum level of sex hormones (Estradiol, Progesterone, and DHEAS) in rheumatoid arthritis (RA) patients. METHODS: The present research was performed on 10 RA patients who had an inadequate response to conventional treatments (clinical trial identifier: IRCT2014011213739N2)...
April 17, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29651973/the-clinical-and-immunological-features-of-patients-with-primary-antibody-deficiencies
#15
Gholamreza Azizi, Yasser Bagheri, Marzieh Tavakol, Forough Askarimoghaddam, Kiyoomars Poorrostami, Hosein Rafiemanesh, Reza Yazdani, Fatemeh Kiaee, Sima Habibi, Kosar Abouhamzeh, Hamed Mohammadi, Mostafa Qorbani, Hassan Abolhassani, Asghar Aghamohammadi
BACKGROUND: Primary antibody deficiency (PAD) comprises a range of diseases from early to late terminal B cells defects and is associated with the various clinical complications. METHODS: A total of 461 patients (311 males and 150 females) with PADs enrolled in the retrospective cohort study and for all patients' demographic information, clinical records and laboratory data were collected to investigate clinical complications. RESULTS: The most prevalent first presentations of immunodeficiency were respiratory tract infections in 63...
April 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29623823/low-25-hydroxyvitamin-d-levels-are-independently-associated-with-autoimmune-thyroiditis-in-a-cohort-of-apparently-healthy-overweight-and-obese-subjects
#16
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595115/efficacy-and-non-invasive-treatment-of-sialorrhea-in-the-goldenhar-syndrome
#17
R Marvulli, G A Gallo, L Mastromauro, P Fiore, G Ianieri, M Megna
Goldenhar syndrome (ocular-auricular-vertebral syndrome), a rare congenital condition arising from defects in the first and second brachial arches, consists in clinical variety of features ranging from facial abnormalities, ear-eye abnormalities, vertebral defects and congenital heart problems and severe obstructive sleep apnea. Due to craniofacial abnormalities, patients presents mechanical obstructive phenomena and sialorrhea that cause prone position, language's fastening, use of nasopharyngeal cannulas and tracheal intubation...
March 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595118/evaluation-of-the-antidiabetic-property-of-capparis-ovata-desf-var-palaestina-zoh-extracts-using-in-vivo-and-in-vitro-approaches
#18
Mehmet Evren Okur, Derya Cicek Polat, Hanefi Ozbek, Sezen Yilmaz, Aysegul Yoltas, Rana Arslan
This paper focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. </p><p> Methods: Alloxan-induced diabetic BALB-c mice were administered intraperitoneally with 100, 300, 500mg/kg doses of ethanol and aqueous extracts of buds and fruits. Furthermore, HPLC, phenolic and flavonoid compounds analysis, ABTS and DPPH free radical scavenging activity, anti-inflammatory activity, agar well diffusion and MIC tests were carried out...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#19
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595116/ameliorative-potentials-of-methanol-fractions-of-cnidoscolus-aconitifolius-on-some-hematological-and-biochemical-parameters-in-streptozotocin-diabetic-rats
#20
Ngozi Achi, Christopher Ohaeri, Ifeoma Ijeh, Chinedum Eleazu, Kalu Igwe, Chima Onyeabo
There is paucity of information in literature on the effect of Cnidoscolus aconitifolius on the hematological, coagulation activities, electrolyte balance and antioxidant activities of humans or animals. </p><p> Objectives: To determine the ameliorative potentials of methanol fractions of Cnidoscolus aconitifolius on hematological, coagulation, electrolyte, hepatic and renal antioxidant activities of streptozotocin- induced diabetic rats using standard techniques. </p><p> Method: Thirty rats, distributed into five groups of six rats each were used for this study...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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