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Endocrine, Metabolic & Immune Disorders Drug Targets

Sandugash Dyussenova, Bibigul Tukbekova, Saule Kizatova, V Tattigul, Karlygash Zhubanysheva, Kulzia Zhaktaeva, Saida Sadvakassova, Gulmira Serikova, V Nazym, Aiman Issayeva
Purpose was to assess the status of protein and lipid oxidative metabolism as a pathogenic link of acute rheumatic fever by measuring markers of early lesion. The analysis of lipid peroxidation and antioxidant protection indicators revealed unidirectional changes that confirm significant cellular membrane lesion. In addition, the determined changes correlated with the activity level of the pathological process while comparing the indicators of ill children in remission and during exacerbation. It was found that despite the active traditional treatment in hospitals for in-patients, a number of studied indicators did not return to normal in remission...
October 19, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Emilio Jirillo, Thea Magrone
Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors. In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, we reasoned that they may act as protective agents against EMR-mediated alterations of human leukocytes. In this direction, our data will show that 1 h pre-treatment of human healthy leukocytes with two polyphenol preparations from red grape before EMR exposure (1...
October 3, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Burak Yulug, Lutfu Hanoglu, Ahmet Mithat Tavli, Tansel Cakır, Elmir Khanmammadov, Oktay Olmuscelik
BACKGROUND: Studies have already shown that hyperglycemia and insulin resistance is significantly associated with the impairment of cerebral glucose metabolism that may secondary lead to cognitive disturbances. In this study, we aimed to evaluate the neurometabolic correlates of diabetes in a patient with Intermittent explosive disorder (IED). METHODS: We have investigated the cerebral glucose metabolism via 2-[18F]-fluoro-2- deoxy-D-glucose positron emission tomography (FDG-PET) in a diabetic patient with aggressive outbursts...
September 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Thea Magrone, Emilio Jirillo
Cigarette smoke (CS) accounts for the outcome of several pathologies, even including lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD). Under healthy conditions, lung immune system becomes tolerant in response to various external stimuli. CS exposure alters the pulmonary immune equilibrium, thus leading to a condition of hyper activation of the local innate and adaptive immunity. COPD is one of the major complications of chronic CS exposure where a pro-inflammatory profile of the pulmonary and systemic immunity is predominant...
September 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Marlene Remely, Berit Hippe, Julia Zanner, Eva Aumueller, Helmuth Brath, Alexander G Haslberger
Beside the influence of nutritional habits and reduced physical activity, metabolic syndrome is associated with alterations in the structure of gut microbiota influencing the inflammatory immune responses. Gut microbiota and microbial metabolic activities are known to affect the lipid and glucose metabolism, satiety and chronic low-grade inflammation in the metabolic syndrome. The aim of the study was to identify genera or even species affecting host metabolism in obesity and type 2 diabetes beside the commonly used indicator: Firmicutes/Bacteroidetes ratio...
August 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Adrian Man, Anca Mare, Felicia Toma, Augustin Curticăpean, Luigi Santacroce
: The study of fungal contamination in food and mycotoxicoses is a priority today, both internationally and nationally. The purpose of this study is to have a general view over the quality of the most common spices that are sold in Romanian markets, by assessing the degree of fungal, bacterial and mycotoxin contamination in pepper and chili powders. METHODS: we tested four types of spices: white pepper, black pepper, sweet and hot chili powders from 12 different distributing companies, summing a total of 35 sample types...
August 23, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Kazuki Santa, Tomonori Ohsawa, Takehiko Sakimoto
Human autoimmune diseases are caused by a variety of factors, such as environmental chemicals, including para-nonylphenol. Macrophages play many critical roles in the regulation of immunity and the progression of autoimmune diseases. However, little information is available regarding the effects of para-nonylphenol on cellular signaling pathways and the death of these cells in vitro. Here, we show that very high concentrations of para-nonylphenol (50-100 µM) induce apoptosis in U937 human monocyte leukemia cells in a dose-dependent manner...
August 19, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Himadri Singh, Vijayalakshmi Venkatesan
Inadequate functional beta cell mass seems to be the primary cause of type 2 diabetes. Increased oxidative stress and inflammation are is the leading cause of beta-cell death. Preservation of functional beta-cell mass in type 2 diabetes is a critical target for type 2 diabetes management. Numerous studies have demonstrated a beneficial effect of dietary components on beta cells management in type 2 diabetes, through multiple mechanisms. These dietary components modulate intercellular cascades which inhibit inflammatory molecule synthesis, the formation of free radicals, nuclear damage and induces antioxidant enzyme expression...
July 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Bedia Guleryuz, Fulya Akin, Melek T Ata, Mukaddes Mergen Dalyanoglu, Sebahat Turgut
BACKGROUND: Hashimoto's thyroiditis (HT) is a common autoimmune disease. Vitamin D is an important regulator of immune system. It has been shown in several studies that vitamin D prevents the development of lots of autoimmune diseases. There are some studies that prove vitamin D receptor (VDR) gene polymorphism increases the risk of Hashimoto's thyroiditis. In this study, we aimed to investigate the association between HT and level of 25(OH)D3, IL-2, IL-4, IL-5, TNF-α and IFN-γ and VDR FokI and TaqI gene polymorphism...
July 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Gholamreza Azizi, Hassan Abolhassani, Nima Rezaei, Asghar Aghamohammadi, Mohammad Hosein Asgardoon, Javad Rahnavard, Majid Zaki Dizaji, Reza Yazdani
Immunoglobulin therapy represents a lifesaving intervention for many patients with primary immunodeficiency (PID). Antibody defects represent approximately half of the well-known PIDs requiring immunoglobulin replacement therapy. Following immunoglobulin therapy in PID patients, protection against serious upper and lower respiratory tract infections and pulmonary function improves which leads to an increase in the quality of life of these patients. Successful treatment of PID patients depends on the type of immunodeficiency, regular monitoring of the patient, co-morbidities of the patient, and the availability of the products...
July 24, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Jun Hejun8067 163 Com He, Hongmei Xie, Shan Wu
BACKGROUND: Activation of the nuclear factor-kappa b (NF-κB) signaling results in releasing of a variety of inflammatory cytokines that can induce skeletal muscle wasting (MW) in mammals. Curcumin is a natural product from spice turmeric that can block biological events in which NF-κB plays a critical role. OBJECTIVE: The present study was conducted to evaluate the beneficial effects of curcumin on the NF-κB-dependent MW in rats. METHODS: The MW rats were induced by lipopolysaccharide (LPS) injection and rats were fed 15 g curcumin per kg diet for 16 d...
June 13, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Adel A Hagag, Ibrahim M Badraia, Mohamed S Elfarargy, Amany M Abo El-Enein
BACKGROUND: Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. RBCs hemolysis and repeated blood transfusions are the major causes of secondary iron overload which leads to deposition of iron in different endocrine glands. Delayed puberty and hypogonadism are the most obvious clinical consequences of iron overload. The aim of this study was to evaluate male sex hormone levels in male children with β- thalassemia major in correlation with iron overload...
May 24, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Thea Magrone, Graziana Ianniello, Rosalba Buquicchio, Vito Galantino, Emilio Jirillo, Maria Teresa Ventura
Anisakiasis is a zoonosis due to infection with the nematode Anisakis (A.) simplex. Humans represent an accidental host after ingesting raw fish infected with A. simplex. A. simplex larvae lead to a robust host immune response mostly at gastro-intestinal level and, usually, T helper (h)2 lymphocytes play a protective against this nematode. However, larvae can elude immunity triggering activation of T regulatory (Treg) cells, which, in turn, suppress Th2 responses via production of interleukin (IL)-10. According to our own experience in the area of Bari (south Italy) where anisakiasis is endemic, chronic urticaria (CU) is very often associated to A...
May 6, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Adel A Hagag, Ibrahim M Badraia, Mohamed S Elfarargy, Amany M Abo El-Enein
BACKGROUND: Beta-thalassemia is a hereditary blood disorder characterized by reduced or absent beta globin chain synthesis, resulting in reduced hemoglobin in red blood cells, decreased RBC production and anemia. Patients with thalassemia major require repeated blood transfusions which lead to accumulation of iron in different tissues, including tissues of endocrine glands. The aim of this work was to evaluate serum levels of gonadal hormones in adolescent females with β- thalassemia in relation to iron overload...
May 6, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Sonny Bherwani, A S Saumya, Ashok Kumar Ahirwar, A S Sandhya, Brijesh Prajapat, Sitendu Patel, Ritu Singh, L H Ghotekar
INTRODUCTION: Diabetic Mellitus is the chronic metabolic illness characterised by hyperglycemia and various complications of heart, eyes, nerves, kidney etc. Diabetic Nephropathy is the leading causes of morbidity and mortality in diabetic patient. We hypothesized that decrease serum folic acid levels associated with Diabetic Nephropathy. MATERIALS AND METHOD: Our study population consist of 100 subjects out of which 50 cases of Diabetes Mellitus without Diabetic Nephropathy and 50 cases of Diabetes Mellitus with Diabetic Nephropathy...
April 15, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Nekić Vanesa, Loga Zec Svjetlana, Šutković Jasmin
Metabolic syndrome, described as one of the most common clustering metabolic risk factors in the world, combines minimum three of the following five risk factors: central obesity, elevated fasting glucose, lipid disorders, arterial hypertension and high serum triglycerides. International Diabetes Federation (IDF) in 2009 defined abdominal obesity as the waist circumference of ≥80 cm in women and ≥ 94 cm in men. The research goal of this study is to analyze the anthropometric risk factors for metabolic syndrome, their correlation and effects on metabolic indices related to metabolic syndrome in the analyzed population...
February 8, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Camila Toffoli Ribeiro, Paulo Louzada Júnior, Marcos Felipe Silva de Sá
UNLABELLED: The correlation of prolactin (PRL) levels with SLE activity is a controversial issue, which could be explained by the presence of macroprolactin (MPRL), a high molecular weight form of PRL with a lower in vivo biological activity. OBJECTIVES: We aimed to evaluate the prevalence of hyperprolactinemia, PRL and MPRL levels in SLE patients, and to correlate these levels with disease activity as measured by the SLE Disease Activity Index (SLEDAI). MATERIAL AND METHODS: We conducted a case-control, cross-sectional study with 73 SLE patients (L group), sixty-two of which were evaluated before and after treatment, and correlated the results with serum PRL and MPRL levels...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Umut Safer, Vildan Binay Safer, Sibel Ozbudak Demir, Inci Yanikoglu
BACKGROUND: Postmenopausal osteoporosis has been linked to accelerated cognitive decline; however, little is known about the effects of medical treatment on cognitive functions. MATERIAL AND METHODS: In this prospective study, we evaluated the effects of bisphosphonate treatment and calcium plus vitamin D supplementation on cognitive functions in 45 women with postmenopausal osteoporosis who were started on medical treatment. The medications included alendronate, zoledronic acid, risedronate, or ibandronic acid along with a low or high dose of calcium plus vitamin D supplements...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Berçem Ayçiçek Doğan, Ayse Arduc, Mazhar Müslüm Tuna, Dilek Berker, Nilgün Demirci, Semra Demirtaş, Hülya Çiçekcioğlu, Serdar Güler
AIM: Cabergoline is related to an elevated risk of fibrotic adverse reactions including cardiac valvular and pleuropulmonary fibrosis. We investigated pulmonary and cardiac valve fibrosis and immunological markers before and after 3 and 12 months of treatment with cabergoline in women with prolactinoma. MATERIAL-METHODS: The study included thirty-two women with newly diagnosed prolactinoma and 28 healthy women. CAB cumulative dose was 7.8±5.5 mg after 3-month therapy, and 31±22 mg after 12-month follow-up...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Maxwell Omabe, Kenneth Nwobini Omabe, Famurewa Ademola Clement, Grace Maxwell Omabe
BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous condition with wide range of phenotype the cause of this disorder is unknown, however, increased ovarian androgen production including increased theca cell responsiveness to gonadotropin stimulation, increased pituitary secretion of luteinizing hormone, and hyperinsulinemia have been suggested. Some known risk factors are ethnicity and environmental factors including lifestyle and bodyweight. METHOD: Relevant English language studies from January 1995 to September 2015 were identified, reviewed, synthesized and discussed extensively...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
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