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Endocrine, Metabolic & Immune Disorders Drug Targets

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https://www.readbyqxmd.com/read/29219063/an-insight-on-the-pathogenesis-and-treatment-of-systemic-lupus-erythematosus
#1
Murtaza Ali, Chelapram K Firoz, Nasimudeen R Jabir, Mohd Rehan, Mohd Shahnawaz Khan, Shams Tabrez
BACKGROUND AND OBJECTIVE: Systemic lupus erythematosus (SLE) is a diverse autoimmune disorder, evoked in response to self-immune system that leads to immune complex depositions and organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental factors have been suggested in the literature that could influence its pathogenesis. The modulation in B- and T- cell responses and genetic variations could lead to abnormal lymphocyte functions and the production of antibodies against the indigenous proteins and the immune complex depositions...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29219062/assesment-of-irisin-adiponectin-and-leptin-levels-in-patients-with-schizophrenia
#2
Gamze Erzin, Canan Topcuoglu, Vahap Ozan Kotan, Senol Bayram, Kostas Fountulakis
BACKGROUND: The patients with schizophrenia are at increased risk for problems regarding metabolic parameters due to their lifestyle and antipsychotic treatment. OBJECTIVE: In this study, we aimed to evaluate the levels of adiponectin, leptin, irisin in patients with schizophrenia who were nondiabetic, nonobese and under antipsychotic treatment. METHOD: 5 ml sample of venous blood was collected from each participant. Blood cells were separated from the serum...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29219061/effect-of-conjugated-linoleic-acid-supplementation-on-serum-leptin-concentration-a-systematic-review-and-meta-analysis
#3
Fahimeh Haghighatdoost, Mitra Hariri
BACKGROUND: There are controversies regarding the effect of conjugated linoleic acid (CLA) on serum leptin. OBJECTIVE: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of CLA on serum leptin concentrations. METHOD: Databases such as Ovid, PubMed/Medline, SCOPUS, Google Scholar, and ISI databases up to January 2017 were searched. The searches included RCTs conducted among human adults, and studies on the effect of conjugated linoleic acid on serum leptin concentrations as outcome variables...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29189183/ige-sensitization-to-anisakis-simplex-and-diet-recommendation-in-a-polycentric-study
#4
Rosalba Buquicchio, Maria Teresa Ventura, Pier Luigi Traetta, Saverio Nenna, Giuseppe Iadarola, Thea Magrone
BACKGROUND: Allergy to Anisakis simplex (s.) is spreading due to the increased consumption of raw, smoked or marinated fish. In humans, Anisakis s. can directly attack the gastrointestinal mucosa, provoking a parasitosis known as anisakiasis, or giving rise to the formation of IgE and, finally, inducing IgE-mediated reactions like urticaria, angioedema and anaphylactic shock. During recent years, a dietary approach to Anisakis s. infestation has also been addressed. METHODS: A total of 620 patients with urticaria, angioedema, or both and a history of anaphylaxis following consumption of raw, smoked or marinated fish were recruited, evaluated for specific IgE levels to Anisakis s...
November 29, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29173190/migraine-in-systemic-autoimmune-diseases
#5
Cavestro Cinzia, Ferrero Marcella
BACKGROUND AND OBJECTIVE: Migraine and systemic autoimmune diseases are 2-3-fold more common in women and various studies have reported an association between the two pathologies. METHODS: This review takes into account epidemiological studies involving migraine and systemic lupus erythematosus, antiphospholipid syndrome, Sjogren's syndrome, and other diffuse connective tissue diseases. This scientific literature analysis consists of the main articles found in Medline with a search up to April 2017...
November 24, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29173189/quality-of-life-in-individuals-affected-by-arnold-chiari-malformation-comparison-and-validation-of-a-measurement-instrument
#6
Antonio Martinez-Sabater, Maria Luisa Ballestar-Tarin, Miriam Vazquez-Seoane, Lucia Mari-Avargues, Carlos Saus-Ortega, Maria Del Carmen Casal-Angulo
BACKGROUND: Introduction. Arnold Chiari Malformation (ACM) type I is a pathology whose symptomatology has repercussions for the quality of life of those affected by it. Quality-of-life measurement instruments can allow the severity of the impact of Chiari type I malformation on patients' lives to be monitored. The Chiari Symptom Profile (CSP) is a valid and reliable instrument designed for this purpose. The aim of the study was to adapt the CSP to Spanish and to explore the reliability and validity of this construct in the context of Spanish-speaking patients with ACM...
November 23, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#7
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165097/a-predictive-model-of-the-prevalence-of-delirium-in-elderly-subjects-admitted-to-nursing-homes
#8
Pilar Perez-Ros, Francisco Miguel Martinez-Arnau, Susana Baixauli-Alacreu, Jose Fermin Garcia-Gollarte, Francisco Tarazona-Santabalbina
INTRODUCTION: Delirium is common in geriatric patients admitted to nursing homes, with an incidence of 22-79% among long-term residents. AIM: To establish a predictive model of the risk of delirium episodes in a sample of elderly people living in nursing homes. MATERIAL AND METHODS: A retrospective, cross-sectional case-control study covering a period of 12 consecutive months (April 2014 - March 2015) was carried out. The included cases had suffered at least one episode of delirium during the study period...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165096/depression-and-self-efficacy-in-patients-with-type-2-diabetes-in-nothern-greece
#9
Paraskevi Sympa, Eugenia Vlachou, Kyriakos Kazakos, Ourania Govina, George Stamatiou, Maria Lavdaniti
BACKGROUND: Depression represents one of the most common disorders in diabetic patients and frequently complicates the health care of this population. Poor self-efficacy has been associated with increased depressive symptoms as well as poor glycemic control. OBJECTIVE: Τo assess depression and self-efficacy in adults with type 2 diabetes in Northern Greece and to explore the factors which may affect them in this group of population. METHOD: A descriptive study was conducted in a tertiary hospital in the largest city of Northern Greece...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165095/metabolic-syndrome-and-cardiovascular-risk-in-people-treated-with-long-acting-injectable-antipsychotics
#10
Vanessa Sanchez-Martinez, Dolores Romero-Rubio, Maria Jose Abad-Perez, Maria Amparo Descalzo-Cabades, Sofia Alonso-Gutierrez, Jose Salazar-Fraile, Vicente Montagud, Lorenzo Facila
BACKGROUND: People with schizophrenia and other severe mental disorders have an increased mortality mainly attributed to natural causes, specifically cardiovascular disease and cancer. The metabolic syndrome and the Framingham Risk Score are epidemiologic tools related to long-term cardiovascular disease risk and they are increased in people with severe mental disorders. This increase has been attributed both to the disorder itself and to the use of antipsychotic drugs. OBJECTIVE: To quantify the cardiovascular risk in a group of people treated with long-acting injectable antipsychotics...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149823/olive-oil-related-anti-inflammatory-effects-on-atherosclerosis-potential-clinical-implications
#11
Tanakal Wongwarawipat, Nikolaos Papageorgiou, Dimitrios Bertsias, Gerasimos Siasos, Dimitris Tousoulis
BACKGROUND AND OBJECTIVE: Atherosclerosis is characterized by a chronic low-grade inflammatory process which can result in atherothrombosis and a number of cardiovascular diseases (CVD). It is believed to be caused by multiple processes that involve inflammation and immunity. Mediterranean Diet (MedD) has been discovered to possess anti-inflammatory properties and associated with a reduction in the CVD risk and mortality. Its main component, extra-virgin olive oil (EVOO), is believed to be largely responsible for these effects and therefore, has been investigated in various studies...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149822/olive-leaf-extracts-act-as-modulators-of-the-human-immune-response
#12
Thea Magrone, Anna Spagnoletta, Rosaria Salvatore, Manrico Magrone, Francesco Dentamaro, Matteo Antonio Russo, Graziana Difonzo, Carmine Summo, Francesco Caponio, Emilio Jirillo
BACKGROUND: Olive tree leaves have been used in the Mediterranean area as traditional medicine in virtue of their healthy effects. Olive leaf extracts (OLEs) contain higher amounts of polyphenols than those detected in the extra virgin olive oil and fruit. Several lines of evidence support the cardioprotective, anti-oxidant and anti-inflammatory activities exerted by OLEs. METHODS: Peripheral blood mononuclear cells (PBMCs) from twenty-five healthy donors were cultured in the presence of 3 μg of two OLE extracts, extract A (resuspended in water) and extract B (resuspended in 70% ethanol)...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149821/statins-therapy-for-connective-tissue-diseases-new-therapeutic-opportunities
#13
Przemyslaw J Kotyla, Eugene J Kucharz
Background and Objective Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductase inhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently, the properties of statins, separate from their lipid lowering activity have attracted much attention. These properties that cover a wide area of physiopathological activities including cell maturation, immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity. Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity, reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelial activity and damage...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141573/liver-protective-effects-of-extra-virgin-olive-oil-interaction-between-its-chemical-composition-and-the-cell-signaling-pathways-involved-in-protection
#14
Sandra A Soto-Alarcon, Rodrigo Valenzuela, Alfonso Valenzuela, Luis A Videla
BACKGROUND AND OBJECTIVE: The liver is an organ susceptible to a multitude of injuries that causes liver damage, like steatosis, non-alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and ischemia-reperfusion injury. Extra virgin olive oil (EVOO), presents several protective effects on the liver, reducing hepatic steatosis, hepatocyte ballooning, fibrogenesis, preventing lipid peroxidation, among other effects. Due to its high levels of monounsaturated fatty acids, mainly oleic acid and phenolic compounds, such as hydroxytyrosol and oleuropein, EVOO is able to participate in the activation of different signaling pathways in the hepatocytes involved in the prevention of inflammation, oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and insulin resistance, allowing the prevention or resolution of liver damage...
November 14, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141572/a-clinical-update-and-global-economic-burden-of-rheumatoid-arthritis
#15
Syed Ali Fazal, Mohammad Khan, Shamima Easmin Nishi, Fahmida Alam, Nowshin Zarin, Mohammad Tariful Bari, Ghulam Md Ashraf
Rheumatoid arthritis (RA) is a predominant inflammatory autoimmune disorder. The incidence and prevalence of RA is increasing with considerable morbidity and mortality worldwide. The pathophysiology of RA has become clearer due to many significant research outputs during the last two decades. Many inflammatory cytokines involved in RA pathophysiology and the presence of autoantibodies are being used as potential biomarkers via the use of effective diagnostic techniques for the early diagnosis of RA. Currently, several disease-modifying anti-rheumatic drugs are being prescribed targeting RA pathophysiology, which have shown significant contributions in improving the disease outcomes...
November 14, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141571/extra-virgin-olive-oil-and-cardiovascular-diseases-benefits-for-human-health
#16
Cristina Nocella, Vittoria Cammisotto, Luca Fianchini, Alessandra D'Amico, Marta Novo, Valentina Castellani, Lucia Stefanini, Francesco Violi, Roberto Carnevale
BACKGROUND AND OBJECTIVE: The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out the close relationship between the Mediterranean diet and cardiovascular diseases. In this context, extra virgin olive oil (EVOO), the most representative component of this diet, seems to be relevant in lowering the incidence of cardiovascular events, including myocardial infarction and stroke...
November 14, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141575/the-protective-effects-of-extra-virgin-olive-oil-on-immune-mediated-inflammatory-responses
#17
Rosa Casas, Ramon Estruch, Emilio Sacanella
BACKGROUND AND OBJECTIVE: The increasing interest in the Mediterranean diet (MeDiet) hinges on the relevant role it plays in inflammatory diseases. Several clinical, epidemiological and experimental evidences suggest that consumption of the MeDiet reduces the incidence of certain pathologies related to oxidative stress, chronic inflammation and immune system diseases such as cancer, atherosclerosis and cardiovascular disease (CVD). DISCUSSION: These reductions can be partially attributed to extra virgin olive oil (EVOO) consumption which has been described as a key bioactive food because of its high nutritional quality and its particular composition of fatty acids, vitamins and polyphenols...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141574/anti-inflammatory-activity-of-extra-virgin-olive-oil-polyphenols-which-role-in-the-prevention-and-treatment-of-immune-mediated-inflammatory-diseases
#18
Carmela Santangelo, Rosaria Vari, Beatrice Scazzocchio, Patrizia De Sanctis, Claudio Giovannini, Massimo D'Archivio, Roberta Masella
Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial effects on health of EVOO have been attributed, besides to the monounsaturated fats content, to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141570/effect-of-extra-virgin-olive-oil-and-table-olives-on-the-immune-inflammatory-responses-potential-clinical-applications
#19
Caterina Maria Gambino, Giulia Accardi, Anna Aiello, Giuseppina Candore, Giovanni Dara-Guccione, Mario Mirisola, Antonio Procopio, Giusi Taormina, Calogero Caruso
Extra virgin olive oil (EVOO) is the common element between the Mediterranean countries. It can be considered a nutraceutical and functional food, thanks to its bioactive compounds. It can act and modulate different processes linked to ageing and age-related diseases related to a common chronic low grade inflammation. Depending on the cultivar, the growth conditions, the period of harvesting, the productive process and time of product storage, EVOO could contain different amount of vegetal components. Of course, the same is for table olives...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29119939/mannose-binding-lectin-protein-deficiency-among-patients-with-primary-immunodeficiency-disease-receiving-ivig-therapy
#20
Gholamreza Azizi, Fatemeh Kiaee, Naeimeh Tavakolinia, Hosein Rafiemanesh, Sara Mohammadikhajehdehi, Laleh Sharifi, Reza Yazdani, Hassan Abolhassani, Asghar Aghamohammadi
BACKGROUND: Primary immunodeficiencies (PIDs) are inherited disorders in which one or several components of the immune system are defective. Immunoglobulin replacement therapy is the mainstay of treatment for patients with impaired antibody production. However, recurrent infections would continue to occur in some patients due to the other high frequent concomitant defects such as mannose-binding lectin (MBL) deficiency. METHODS: A total of 51 PID patients participated in this cross-sectional study...
November 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
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