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Endocrine, Metabolic & Immune Disorders Drug Targets

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https://www.readbyqxmd.com/read/27908264/hypoxia-and-inflammation-in-prostate-cancer-progression-cross-talk-with-androgen-and-estrogen-receptors-and-cancer-stem-cells
#1
Matteo A Russo, Linda Ravenna, Laura Pellegrini, Elisa Petrangeli, Luisa Salvatori, Thea Magrone, Massimo Fini, Marco Tafani
Tumors are complex tissues in which transformed cells communicate with the surrounding microenvironment and evolve traits promoting their own survival and malignancy. Hypoxia and inflammation are constant characteristics of prostate tumor microenvironment influencing both cancer stem cells and differentiated tumor cells. HIFs and NF-kB are the key regulators of the transcriptional response to hypoxic and inflammatory stresses, respectively, and a crosstalk between HIFs and NF-kB pathways has been widely documented...
November 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27908263/prevalence-and-predictors-of-overweight-and-obesity-in-patients-with-pituitary-dysfunctions
#2
Birgit Harbeck, Sven Danneberg, Amir Hossein Rahvar, Heiner Mönig, Christian Stefan Haas
BACKGROUND: Patients with hypothalamic-pituitary disorders (HPD) may be of increased risk to develop overweight and obesity, thereby fostering cardiovascular events. However, it remains unclear if patients with pituitary dysfunctions per se have an increased risk of becoming obese. OBJECTIVE: The objective of this study was to evaluate prevalence and to identify possible predictors of overweight and obesity in patients with pituitary dysfunctions. METHODS: A total of 121 out-patients having various causes for HPD were assessed for height and body weight; body mass index (BMI) was calculated and correlated with clinical features...
November 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27908262/sleep-alterations-in-non-demented-older-individuals-the-role-of-cortisol
#3
Ana Belén Castelló-Domenech, Vanessa Ibáñez Del Valle, Julio Fernández-Garrido, Mary Martínez-Martínez, Omar Cauli
BACKGROUND: Sleep alterations can impair quality of life and contribute to disease progression but they, and their features and contributing factors, are rarely analysed in institutionalised older individuals. In this study we investigated sleep alterations, the factors involved, and the role of cortisol in sleep-related problems in institutionalised individuals. METHODS: We conducted a descriptive cross-sectional study in participants living in nursing homes in Valencia (Spain); sleep alterations were determined based on two validated tools: the Athens insomnia scale and Oviedo sleep questionnaire...
November 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27829333/immune-status-in-children-with-beta-thalassemia-in-correlation-with-iron-overload-single-center-egyptian-study
#4
Adel Abd Elhaleim Hagag, Mohamed A Elgamsy, Hassan M El-Asy, Rasha M Gamal, Walid N Elshahaby, Enaam S Abd Elbar
BACKGROUND: 'Beta thalassemia is inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy'. 'Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload', which in addition to immune abnormalities, are common predisposing factors to infection in patients with thalassemia. Aim of this work was to study immune status including T lymphocyte subsets and serum immunoglobulin levels 'in children with beta- thalassemia in correlation with iron overload'...
November 7, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27809748/preventative-effect-of-vitamin-e-on-mast-cells-in-carbon-tetrachloride-induced-acute-liver-damage
#5
Ayhan Eralp, Nur Yumusak Menguc, Elif Polat, Mehmet Yuncu, Mehmet Koruk, Serap Sergul Inaloz Demir, İbrahim Sarı
Preventing liver damage that might lead to cirrhosis is very important in the early stages of injury to that organ. The role of mast cells (MCs) in liver injuries has been long debated, and vitamin E is a well-known antioxidant used to treat those injuries. This study aimed to determine the protective role of vitamin E on MCs in injury to the liver that is triggered by carbon tetrachloride (CCl4). There is a correlation between MC deposits and improvement in fibrosis tissues. To further examine this, 68 male Albino Wistar rats were divided randomly into five groups: the control group, the vitamin E group, the CCl4 group, the CCl4 + vitamin E group, and the vitamin E + CCl4 group...
October 29, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27784231/effect-of-oral-methadone-on-ecg-characteristics-and-endocrine-hormonal-changes-and-their-inter-relationship
#6
Shokoufeh Bonakdaran, Mahdi Hassan Zadeh Daloee, Ali Akhoondpoor Manteghi, Mina Akbarirad, Abdollah Firoozi, Fatemeh Akbarirad
INTRODUCTION: Methadone is the most common opioid in use for opioid substitution therapy. The Relation of methadone and electrocardiographic findings is nearly well known while the relationship between its electrocardiographic indexes and hormonal changes are not well recognized. OBJECTIVE: To evaluate the hormonal changes in patients who are taking methadone maintenance treatment (MMT) and its effects on electrocardiographic indexes, in comparison with healthy control groups...
October 26, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27774884/peculiarities-of-the-clinical-course-of-oxidative-protein-and-lipid-modification-in-children-with-acute-rheumatic-fever
#7
Sandugash Dyussenova, Bibigul Tukbekova, Saule Kizatova, V Tattigul, Karlygash Zhubanysheva, Kulzia Zhaktaeva, Saida Sadvakassova, Gulmira Serikova, V Nazym, Aiman Issayeva
Purpose was to assess the status of protein and lipid oxidative metabolism as a pathogenic link of acute rheumatic fever by measuring markers of early lesion. The analysis of lipid peroxidation and antioxidant protection indicators revealed unidirectional changes that confirm significant cellular membrane lesion. In addition, the determined changes correlated with the activity level of the pathological process while comparing the indicators of ill children in remission and during exacerbation. It was found that despite the active traditional treatment in hospitals for in-patients, a number of studied indicators did not return to normal in remission...
October 19, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27697072/morphometrical-and-morphological-alterations-of-human-leukocytes-exposed-to-1-8-ghz-electromagnetic-radiations-in-vitro-protective-effects-induced-by-polyphenols
#8
Emilio Jirillo, Thea Magrone
Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors. In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, we reasoned that they may act as protective agents against EMR-mediated alterations of human leukocytes. In this direction, our data will show that 1 h pre-treatment of human healthy leukocytes with two polyphenol preparations from red grape before EMR exposure (1...
October 3, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27697074/18f-fdg-pet-correlates-of-impulse-control-disorder-in-a-diabetic-patient
#9
Burak Yulug, Lutfu Hanoglu, Ahmet Mithat Tavli, Tansel Cakır, Elmir Khanmammadov, Oktay Olmuscelik
BACKGROUND: Studies have already shown that hyperglycemia and insulin resistance is significantly associated with the impairment of cerebral glucose metabolism that may secondary lead to cognitive disturbances. In this study, we aimed to evaluate the neurometabolic correlates of diabetes in a patient with Intermittent explosive disorder (IED). METHODS: We have investigated the cerebral glucose metabolism via 2-[18F]-fluoro-2- deoxy-D-glucose positron emission tomography (FDG-PET) in a diabetic patient with aggressive outbursts...
September 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27697073/cigarette-smoke-mediated-perturbations-of-the-immune-response-a-new-therapeutic-approach-with-natural-compounds
#10
Thea Magrone, Emilio Jirillo
Cigarette smoke (CS) accounts for the outcome of several pathologies, even including lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD). Under healthy conditions, lung immune system becomes tolerant in response to various external stimuli. CS exposure alters the pulmonary immune equilibrium, thus leading to a condition of hyper activation of the local innate and adaptive immunity. COPD is one of the major complications of chronic CS exposure where a pro-inflammatory profile of the pulmonary and systemic immunity is predominant...
September 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27577947/gut-microbiota-of-obese-type-2-diabetic-individuals-is-enriched-in-faecalibacterium-prausnitzii-akkermansia-muciniphila-and-peptostreptococcus-anaerobius-after-weight-loss
#11
Marlene Remely, Berit Hippe, Julia Zanner, Eva Aumueller, Helmuth Brath, Alexander G Haslberger
Beside the influence of nutritional habits and reduced physical activity, metabolic syndrome is associated with alterations in the structure of gut microbiota influencing the inflammatory immune responses. Gut microbiota and microbial metabolic activities are known to affect the lipid and glucose metabolism, satiety and chronic low-grade inflammation in the metabolic syndrome. The aim of the study was to identify genera or even species affecting host metabolism in obesity and type 2 diabetes beside the commonly used indicator: Firmicutes/Bacteroidetes ratio...
August 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27552982/health-threats-from-contamination-of-spices-commercialized-in-romania-risks-of-fungal-and-bacterial-infections
#12
Adrian Man, Anca Mare, Felicia Toma, Augustin Curticăpean, Luigi Santacroce
: The study of fungal contamination in food and mycotoxicoses is a priority today, both internationally and nationally. The purpose of this study is to have a general view over the quality of the most common spices that are sold in Romanian markets, by assessing the degree of fungal, bacterial and mycotoxin contamination in pepper and chili powders. METHODS: we tested four types of spices: white pepper, black pepper, sweet and hot chili powders from 12 different distributing companies, summing a total of 35 sample types...
August 23, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27550319/para-nonylphenol-induces-apoptosis-of-u937-human-monocyte-leukemia-cells-in-vitro
#13
Kazuki Santa, Tomonori Ohsawa, Takehiko Sakimoto
Human autoimmune diseases are caused by a variety of factors, such as environmental chemicals, including para-nonylphenol. Macrophages play many critical roles in the regulation of immunity and the progression of autoimmune diseases. However, little information is available regarding the effects of para-nonylphenol on cellular signaling pathways and the death of these cells in vitro. Here, we show that very high concentrations of para-nonylphenol (50-100 µM) induce apoptosis in U937 human monocyte leukemia cells in a dose-dependent manner...
August 19, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27468767/beta-cell-management-in-type-2-diabetes-beneficial-role-of-nutraceuticals
#14
Himadri Singh, Vijayalakshmi Venkatesan
Inadequate functional beta cell mass seems to be the primary cause of type 2 diabetes. Increased oxidative stress and inflammation are is the leading cause of beta-cell death. Preservation of functional beta-cell mass in type 2 diabetes is a critical target for type 2 diabetes management. Numerous studies have demonstrated a beneficial effect of dietary components on beta cells management in type 2 diabetes, through multiple mechanisms. These dietary components modulate intercellular cascades which inhibit inflammatory molecule synthesis, the formation of free radicals, nuclear damage and induces antioxidant enzyme expression...
July 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27468766/vitamin-d-receptor-vdr-gene-polymorphisms-taqi-foki-in-turkish-patients-with-hashimoto-s-thyroiditis-relationship-to-the-levels-of-vit-d-and-cytokines
#15
Bedia Guleryuz, Fulya Akin, Melek T Ata, Mukaddes Mergen Dalyanoglu, Sebahat Turgut
BACKGROUND: Hashimoto's thyroiditis (HT) is a common autoimmune disease. Vitamin D is an important regulator of immune system. It has been shown in several studies that vitamin D prevents the development of lots of autoimmune diseases. There are some studies that prove vitamin D receptor (VDR) gene polymorphism increases the risk of Hashimoto's thyroiditis. In this study, we aimed to investigate the association between HT and level of 25(OH)D3, IL-2, IL-4, IL-5, TNF-α and IFN-γ and VDR FokI and TaqI gene polymorphism...
July 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27456825/the-use-of-immunoglobulin-therapy-in-primary-immunodeficiency-diseases
#16
Gholamreza Azizi, Hassan Abolhassani, Nima Rezaei, Asghar Aghamohammadi, Mohammad Hosein Asgardoon, Javad Rahnavard, Majid Zaki Dizaji, Reza Yazdani
Immunoglobulin therapy represents a lifesaving intervention for many patients with primary immunodeficiency (PID). Antibody defects represent approximately half of the well-known PIDs requiring immunoglobulin replacement therapy. Following immunoglobulin therapy in PID patients, protection against serious upper and lower respiratory tract infections and pulmonary function improves which leads to an increase in the quality of life of these patients. Successful treatment of PID patients depends on the type of immunodeficiency, regular monitoring of the patient, co-morbidities of the patient, and the availability of the products...
July 24, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27297427/dietary-supplementation-of-curcumin-alleviates-nf-%C3%AE%C2%BAb-dependent-skeletal-muscle-wasting-in-rat
#17
Jun Hejun8067 163 Com He, Hongmei Xie, Shan Wu
BACKGROUND: Activation of the nuclear factor-kappa b (NF-κB) signaling results in releasing of a variety of inflammatory cytokines that can induce skeletal muscle wasting (MW) in mammals. Curcumin is a natural product from spice turmeric that can block biological events in which NF-κB plays a critical role. OBJECTIVE: The present study was conducted to evaluate the beneficial effects of curcumin on the NF-κB-dependent MW in rats. METHODS: The MW rats were induced by lipopolysaccharide (LPS) injection and rats were fed 15 g curcumin per kg diet for 16 d...
June 13, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27215646/study-of-male-sex-hormone-levels-in-male-egyptian-children-with-beta-thalassemia-correlation-with-iron-load
#18
Adel A Hagag, Ibrahim M Badraia, Mohamed S Elfarargy, Amany M Abo El-Enein
BACKGROUND: Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. RBCs hemolysis and repeated blood transfusions are the major causes of secondary iron overload which leads to deposition of iron in different endocrine glands. Delayed puberty and hypogonadism are the most obvious clinical consequences of iron overload. The aim of this study was to evaluate male sex hormone levels in male children with β- thalassemia major in correlation with iron overload...
May 24, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27150602/cytokine-profile-in-patients-infected-with-anisakis-simplex-in-endemic-areas-dietary-intervention-with-polyphenols-a-working-hypothesis
#19
Thea Magrone, Graziana Ianniello, Rosalba Buquicchio, Vito Galantino, Emilio Jirillo, Maria Teresa Ventura
Anisakiasis is a zoonosis due to infection with the nematode Anisakis (A.) simplex. Humans represent an accidental host after ingesting raw fish infected with A. simplex. A. simplex larvae lead to a robust host immune response mostly at gastro-intestinal level and, usually, T helper (h)2 lymphocytes play a protective against this nematode. However, larvae can elude immunity triggering activation of T regulatory (Treg) cells, which, in turn, suppress Th2 responses via production of interleukin (IL)-10. According to our own experience in the area of Bari (south Italy) where anisakiasis is endemic, chronic urticaria (CU) is very often associated to A...
May 6, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27150601/gonadal-hormones-in-adolescent-females-with-%C3%AE-thalassemia-in-relation-to-iron-load
#20
Adel A Hagag, Ibrahim M Badraia, Mohamed S Elfarargy, Amany M Abo El-Enein
BACKGROUND: Beta-thalassemia is a hereditary blood disorder characterized by reduced or absent beta globin chain synthesis, resulting in reduced hemoglobin in red blood cells, decreased RBC production and anemia. Patients with thalassemia major require repeated blood transfusions which lead to accumulation of iron in different tissues, including tissues of endocrine glands. The aim of this work was to evaluate serum levels of gonadal hormones in adolescent females with β- thalassemia in relation to iron overload...
May 6, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
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