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Endocrine, Metabolic & Immune Disorders Drug Targets

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https://www.readbyqxmd.com/read/29667557/modification-of-sexual-hormones-in-rheumatoid-arthritis-patients-by-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-nsaid-with-immunosuppressive-property
#1
Mozhgan Jahanbakhshi, Zohreh Babaloo, Seyed Shahabeddin Mortazavi-Jahromi, Maryam Monsef Shokri, Hossein Ahmadi, Abbas Mirshafiey
BACKGROUND: Based on in-vitro, in-vivo and human studies, the β-D-mannuronic acid (M2000) has been introduced as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties. OBJECTIVE: This study aimed to evaluate the efficacy of this drug on serum level of sex hormones (Estradiol, Progesterone, and DHEAS) in rheumatoid arthritis (RA) patients. METHODS: The present research was performed on 10 RA patients who had an inadequate response to conventional treatments (clinical trial identifier: IRCT2014011213739N2)...
April 17, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29651973/the-clinical-and-immunological-features-of-patients-with-primary-antibody-deficiencies
#2
Gholamreza Azizi, Yasser Bagheri, Marzieh Tavakol, Forough Askarimoghaddam, Kiyoomars Poorrostami, Hosein Rafiemanesh, Reza Yazdani, Fatemeh Kiaee, Sima Habibi, Kosar Abouhamzeh, Hamed Mohammadi, Mostafa Qorbani, Hassan Abolhassani, Asghar Aghamohammadi
BACKGROUND: Primary antibody deficiency (PAD) comprises a range of diseases from early to late terminal B cells defects and is associated with the various clinical complications. METHODS: A total of 461 patients (311 males and 150 females) with PADs enrolled in the retrospective cohort study and for all patients' demographic information, clinical records and laboratory data were collected to investigate clinical complications. RESULTS: The most prevalent first presentations of immunodeficiency were respiratory tract infections in 63...
April 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29623823/low-25-hydroxyvitamin-d-levels-are-independently-associated-with-autoimmune-thyroiditis-in-a-cohort-of-apparently-healthy-overweight-and-obese-subjects
#3
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595115/efficacy-and-non-invasive-treatment-of-sialorrhea-in-the-goldenhar-syndrome
#4
R Marvulli, G A Gallo, L Mastromauro, P Fiore, G Ianieri, M Megna
Goldenhar syndrome (ocular-auricular-vertebral syndrome), a rare congenital condition arising from defects in the first and second brachial arches, consists in clinical variety of features ranging from facial abnormalities, ear-eye abnormalities, vertebral defects and congenital heart problems and severe obstructive sleep apnea. Due to craniofacial abnormalities, patients presents mechanical obstructive phenomena and sialorrhea that cause prone position, language's fastening, use of nasopharyngeal cannulas and tracheal intubation...
March 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595118/evaluation-of-the-antidiabetic-property-of-capparis-ovata-desf-var-palaestina-zoh-extracts-using-in-vivo-and-in-vitro-approaches
#5
Mehmet Evren Okur, Derya Cicek Polat, Hanefi Ozbek, Sezen Yilmaz, Aysegul Yoltas, Rana Arslan
This paper focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. </p><p> Methods: Alloxan-induced diabetic BALB-c mice were administered intraperitoneally with 100, 300, 500mg/kg doses of ethanol and aqueous extracts of buds and fruits. Furthermore, HPLC, phenolic and flavonoid compounds analysis, ABTS and DPPH free radical scavenging activity, anti-inflammatory activity, agar well diffusion and MIC tests were carried out...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#6
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29595116/ameliorative-potentials-of-methanol-fractions-of-cnidoscolus-aconitifolius-on-some-hematological-and-biochemical-parameters-in-streptozotocin-diabetic-rats
#7
Ngozi Achi, Christopher Ohaeri, Ifeoma Ijeh, Chinedum Eleazu, Kalu Igwe, Chima Onyeabo
There is paucity of information in literature on the effect of Cnidoscolus aconitifolius on the hematological, coagulation activities, electrolyte balance and antioxidant activities of humans or animals. </p><p> Objectives: To determine the ameliorative potentials of methanol fractions of Cnidoscolus aconitifolius on hematological, coagulation, electrolyte, hepatic and renal antioxidant activities of streptozotocin- induced diabetic rats using standard techniques. </p><p> Method: Thirty rats, distributed into five groups of six rats each were used for this study...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29589550/the-effect-of-denatured-flagellin-on-toll-like-receptor-5-tlr-5-in-mice
#8
Alexander Michael Abdelnoor, Soha Mcheik, Nayla S Al AKl
BACKGROUND: Previous studies have demonstrated that flagellin, a component of bacterial flagella, engages Toll- Like receptor 5 (TLR-5) causing the activation of the Myeloid Differentiation Factor-88 (MYD-88) pathway that leads to the production of pro-inflammatory cytokines including Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-12 (IL-12). In physiological levels cytokines can aid in protection against infectious agents. However, excessive production of cytokines can lead to septic shock during sepsis...
March 26, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29589549/effect-of-laparoscopic-sleeve-gastrectomy-on-thyroid-hormones-in-euthyroid-obese-patients
#9
Zeki Ozsoy, Faruk Kutluturk
INTRODUCTION: In obese patients, the incidences of several thyroid disorders have increased in comparison to the general population. This study aimed to investigate the effect of laparoscopic sleeve gastrectomy (LSG) on thyroid function tests in obese patients. METHODS: The patient files of 186 individuals who underwent laparoscopic sleeve gastrectomy surgery were examined retrospectively. Forty-nine females and 29 males comprising a total of 78 patients were included in the study...
March 26, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29557755/the-inhibitory-effect-of-some-drugs-on-candida-rugosa-lipase-and-pancreatic-human-lipase-in-vitro-and-in-silico-studies
#10
Talia Serseg, Khedidja Benarous
Side effects of some drugs may be useful in certain cases. In this work, we studied the inhibitory effects of some medications as: Folic Acid which is taken by pregnant women, Colchicine and Febuxostat which is used as treatment of gout disease. These cases are linked to obesity, where women (BMI ≥ 30) have twice higher odds of having an NTD-affected pregnancy than the normal weight women, and the Gout disease frequently occurs in combination of a Metabolic syndrome. The risk of gout increases with the increase of the mass index...
March 18, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29521254/mechanism-by-which-regulatory-rheumatoid-factor-prevents-experimental-autoimmune-encephalomyelitis
#11
Elena Stolyarova, Liubov Beduleva, Igor Menshikov, Alexandr Snigiryev, Tatyana Khramova
BACKGROUND: One mechanism that underlies protection from autoimmunity and avoidance of uncontrolled inflammation is the controlled contraction of lymphocyte expansion during the immune response. We identified regulatory rheumatoid factor (regRF), the production of which is associated with resistance to and remission of experimental autoimmune diseases. RegRF is anti-idiotypic antibodies to lymphocyte receptors against autoimmune disease-inducing antigens; at the same time, it is specific to epitopes in the hinge Fc fragments of IgG...
March 8, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468987/antithyroid-drugs-inactivate-tsh-binding-to-the-tsh-receptor-by-their-reducing-action
#12
Yukio Ochi, Takashi Hachiya, Yukiko Koyama, Nobutoshi Fukuhori, Noriyuki Ashida
The effect of antithyroid drugs(ATDs)[methylmercaptoimidazole (MMI) and propylthiouracil (PTU)] and reducing agents (mercaptoethanol, dithiothreitol and cysteine) on bovine (b) TSH binding to human (h) and porcine (p) TSH receptor (R) was examined. (1) ATDs was pre-incubated with hTSHR coated tube for 1- 4 h, washed free of ATDs, and then 125I-bTSH binding to hTSHR after 1 h incubation was examined. MMI (10-40 mM) decreased 125I-bTSH binding in a dose-dependent manner and binding decreased proportionally as pre-incubation time increased from 1 to 4 h...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468986/increased-endothelial-dysfunction-and-insulin-resistance-in-patients-with-klinefelter-syndrome
#13
Cem Haymana, Aydogan Aydogdu, Ibrahim Demirci, Mustafa Dinc, Orhan Demir, Deniz Torun, Fatih Yesildal, Coskun Meric, Yalcın Basaran, Alper Sonmez, Omer Azal
Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS. A total of 32 patients with KS (mean age 21.59 ± 1.66 years) and 33 healthy control subjects (mean age: 22.15 ± 1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and high-sensitivity C-reactive protein (hs-CRP) levels were measured...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468985/the-role-of-neurohypophyseal-hormones-vasopressin-and-oxytocin-in-neuropsychiatric-disorders
#14
Michele Iovino, Tullio Messana, Giovanni De Pergola, Emanuela Iovino, Franca Dicuonzo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
Although the neurohypophyseal hormones vasopressin and oxytocin are mostly known for their role respectively in antiduresis the former and in labour, lactation and maternal behavior the latter, both might exert widespread influences either on emotion and cognition in healthy subjects, showing some gender-related differences. They interact one each other facilitating shifts between positive socially- oriented and defensive states. In fact, vasopressin amplifies the reactivity to stressors showing also beneficial effects on attention, verbal learning as well as memory, whereas oxytocin reduces the amplitude of the stress response, improves emotion processing, and can play a negative effect on memory and verbal learning in healthy individuals...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29446750/copaiba-oil-decreases-oxidative-stress-and-inflammation-but-not-colon-damage-in-rats-with-tnbs-induced-colitis
#15
Maiara Morseli Coelho Barbosa, Fernando Augusto Vicentini, Cristiane Vizioli Castro-Ghizoni, Osmar Alves Lameira, Anacharis Babeto Sa-Nakanishi, Livia Bracht, Rosane Marina Peralta, Maria Raquel Marçal Natali, Adelar Bracht, Jurandir Fernando Comar
BACKGROUND: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. OBJECTIVE: to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. METHODS: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS)...
February 14, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29437028/changes-in-the-peripheral-endocannabinoid-system-as-a-risk-factor-for-the-development-of-eating-disorders
#16
Anna Capasso, Walter Milano, Omar Cauli
BACKGROUND AND OBJECTIVE: Eating Disorder (ED) is characterized by persistently and severely disturbed eating behaviours. They arise from a combination of long-standing behavioural, emotional, psychological, interpersonal, and social factors and result in insufficient nutrient ingestion and/or adsorption. The three main EDs are: anorexia nervosa, bulimia nervosa, and binge eating disorder. We review the role of peripheral endocannabinoids in eating behaviour. DISCUSSION: The neuronal pathways involved in feeding behaviours are closely related to catecholaminergic, serotoninergic and peptidergic systems...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29437027/benefits-of-olive-oil-phenolic-compounds-in-disease-prevention
#17
Olga Garcia-Martinez, Concepcion Ruiz, Alvaro Gutierrez-Ibanez, Rebeca Illescas-Montes, Lucia Melguizo-Rodriguez
BACKGROUND AND OBJECTIVE: The preventive effects of olive oil against different diseases have been attributed to its high phenolic compound content. The objective of this study was to examine available scientific evidence on the beneficial effects against chronic diseases of olive oil phenolic compounds. METHOD: This article examines recently published data on olive oil phenolic compounds and their potential benefits in the prevention of cardiovascular disease, cancer, neurodegenerative disease, and osteoporosis...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29437022/lower-urinary-tract-symptoms-in-metabolic-syndrome-in-young-adults
#18
Svetlana Igorevna Kseneva, Zakhar Aleksandrovich Yurmazov, Maksim Sergeevich Timofeev, Elena Valentinovna Borodulina, Vladimir Vasilievich Udut
To assess interconnection between components of metabolic syndrome with lower urinary tract symptoms and level of androgens 30 young patients with metabolic syndrome were examined. The control group consisted of 32 apparently healthy individuals of comparable age. Revealed a high frequency of increasing the size and volume of the prostate gland, the number of points on the IPSS questionnaire, corresponding to the initial manifestation of hyperplastic prostate diseases on the background of insulin resistance and normal androgen levels raises questions about the search for new pathogenetic links of the metabolic syndrome with the processes of induction of prostate growth...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29437021/homocysteine-levels-in-autism-spectrum-disorder-a-clinical-update
#19
Milagros Fuentes-Albero, Omar Cauli
Homocysteine (Hcy) is a non-protein α-amino acid, which plays several important roles in human physiology and in the central nervous system. Although Hcy has several known biological properties in one-carbon metabolism, its overproduction might be harmful and could add to the pathophysiology associated with autism spectrum disorder (ASD). This review presents updated information about alterations in the concentration of this amino acid in biological fluids (blood and urine) in patients with ASD. In addition, we assessed its clinical significance by analyzing if there are any potential associations between abnormal Hcy levels and the severity ASD or any of its symptoms...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29437020/anorexia-nervosa-and-comorbid-psychopathology
#20
Simonetta Marucci, Laura Dalla Ragione, Giulia De Iaco, Tania Mococci, Maria Vicini, Edoardo Guastamacchia, Vincenzo Triggiani
There is great interest, supported by clinical experience, in the relationship between Eating Disorders (EDs) and psychiatric symptoms and diseases. The psychopathology of EDs is also referred to many risk and protective factors, and there is some evidence in the literature, also about genetic and neurobiological factors involved. EDs are often associated with pre-morbid psychiatric disorders, personality disorders, substance abuse, mood and anxiety disorders. The great amount of scientific articles dealing with the relationship between EDs and psychopathology confirms the complexity of these problems and the difficulties in diagnosis and treatment...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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