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Endocrine, Metabolic & Immune Disorders Drug Targets

Thea Magrone, Anna Spagnoletta, Manrico Magrone, Matteo Antonio Russo, Aldo Corriero, Emilio Jirillo, Letizia Passantino
BACKGROUND AND OBJECTIVE: Hepatopancreas is an accessory organ associated to the liver in some fish, even including sea bass (Dicentrharcus labrax L). Hepatopancreas contains an exocrine portion but until now its function has poorly been investigated. METHODS: Here, European farmed sea bass have been treated with a feed enriched in polyphenols extracted from seeds of red grape (Nero di Troia cultivar) at two different doses (100 and 200 mg/kg, respectively) from day 273 to day 323...
October 9, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Gamze Akkus, Mehtap Evran, Murat Sert, Tamer Tetiker
OBJECTIVE: Adrenal incidentalomas are diagnosed incidentally during radiological screenings and requires endocrinological investigations for hormonal activity and malignancy. In certain studies, it has been reported that non-functional incidentalomas can be associated with high adipocytokines levels affecting the insulin resistance just like the adipose tissue with metabolic syndrome. Here, we studied serum adipocytokine levels including leptin, resistin, visfatin, omentin 1 and adiponectin in subjects with non-functional adrenal incidentaloma...
October 9, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Mahdi Goudarzvand, Yaser Panahi, Reza Yazdani, Hosein Miladi, Saeed Tahmasebi, Amin Sherafat, Sanaz Afraei, Kosar Abouhamzeh, Mahnaz Jamee, Kawthar Jasim Mohammad Rida Al-Hussieni, Hamed Mohammadi, Ali Mohebbi, Nikoo Hossein-Khannazer, Majid Zaki-Dizaji, Maria Maddalena Di Fiore, Antimo D'Aniello, Gholamreza Azizi
OBJECTIVE: Experimental autoimmune encephalomyelitis (EAE) is a widely used model for multiple sclerosis. The present study has been designed to compare the efficiencies of oral and intraperitoneal (IP) administration of D-aspartate (D-Asp) on the onset and severity of EAE, the production of neurosteroids, and the expression of neurosteroid receptors and inflammatory mediators in brain of EAE mice. METHODS: In this study, EAE was induced in C57BL/6 mice treated with D-Asp orally (D-Asp-Oral) or by IP injection (D-Asp-IP)...
October 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Chandan K Jha, Rashid Mir, Imadeldin Elfaki, Naina Khullar, Suriya Rehman, Jamsheed Javid, Shaheena Banu, Sukh Mohinder Singh Chahal
AIM: Studies have evaluated the association of miRNA-423 C>A genotyping with the susceptibility to coronary artery disease but the results were contradictory. However, no studies have reported the association between miRNA-423 rs6505162 C>A polymorphism and susceptibility of coronary artery disease. MicroRNAs regulate expression of multiple genes involved in atherogenesis. Therefore, we investigated the association of microRNA-423C>T gene variations with susceptibility to coronary artery disease...
October 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Omar Farid, Naoufel Ali Zeggwagh, Mohamed Eddouks
OBJECTIVE: The aim of this work was to evaluate the antihyperglycemic activity of aerial parts aqueous extract (A.P.A.E) of Mentha pulegium (M. pulegium) on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rat. Also the glucose tolerance was evaluated in normal rats. Moreover, the histological sections and morphometric analysis at the liver and pancreas have been carried out in this investigation both in normal and STZ-diabetic rats. METHODS: The effect of A...
October 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Sirish C Rao, Anjana Sathyamurthy, Erica P Turse, Francis D Dailey, Veysel Tahan
BACKGROUND: Dysphagia affects one in twenty-five adults yearly in the United States. OBJECTIVE: While dysphagia may be common, the prevalence of dysphagia may be underestimated primarily due to under-reporting. Dysphagia may be caused by intraluminal, intrinsic, extrinsic, or motility disorders. METHOD/RESULTS: We present a case of dysphagia caused by extra-thoracic extrinsic compression due to bra use. CONCLUSION: Despite many published reports on dysphagia caused by other diagnoses, we occasionally overlook extrinsic abdominal compression as the culprit for dysphagia...
October 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Saverio M. Lepore, Valentina Maggisano, Giovanni E. Lombardo, Jessica Maiuolo, Vincenzo Mollace, Stefania Bulotta, Diego Russo, Marilena Celano
BACKGROUND: The sesquiterpene lactone cynaropicrin, a major constituent of the artichoke leaves extracts, has shown several biologic activities in many preclinical experimental models, including anti-proliferative effects. OBJECTIVE: Herein we evaluated the effects of cynaropicrin on the growth of three human anaplastic thyroid carcinoma cell lines, investigating the molecular mechanism underlying its action. METHOD: MTT assay was used to evaluate the viability of CAL-62, 8505C and SW1736 cells, and flow cytometry to analyse cell cycle distribution...
September 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Gianfranco Calogiuri, Claudio Parlangeli, Alessandro Mandurino Mirizzi, Luigi Macchia, Caterina Foti, Michael P Savage
The thienopyridine family includes ticlopidine, clopidogrel and prasugrel which are antiplatelet drugs largely used, mainly associated to aspirin, for treatment of acute coronary syndromes and after percutaneous coronary interventions, to avoid thrombosis. In some patients, thienpyridines may cause hypersensitivity reactions which jeopardize the optimal therapeutic and preventive approach to vascular diseases. The management of thienopyridine hypersensitivity is best done as an interdisciplinary collaboration between the allergist and cardiologist...
September 14, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Adel A Hagag, Hassan M El-Asy, Ibrahim M Badraia, Nahed M Hablas, Amal Ezzat Abd El-Latif
BACKGROUND: 'Sickle cell disease (SCD) is characterized by defective hemoglobin synthesis, hemolytic anemia, frequent thrombosis and chronic organ damage including endocrine organs'. AIM OF THE WORK: to assess thyroid function in children with SCD in correlation with iron load. PATIENTS AND METHODS: This study was conducted on 40 children with SCD with iron overload (serum ferritin more than 1000 ng/ml) including 22 males and 18 females with their ages ranging from 11-14 years and mean age value of 11...
September 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Gaetano Achille, Marco Castellana, Sabino Russo, Massimo Montepara, Vito Angelo Giagulli, Vincenzo Triggiani
BACKGROUND AND OBJECTIVE: Zenker diverticulum (ZD) can sometimes be misinterpreted as a thyroid nodule both at clinical evaluation and at ultrasound (US). CASE PRESENTATION: We reported the case of a 46-years-old woman complaining of a lump in the anterior left aspect of the neck. Following clinical examination and US evaluation, a thyroid nodule was initially diagnosed and the patient was referred to our institution to be submitted to a fine-needle aspiration cytology...
September 10, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Vincenzo Triggiani, Marco Castellana, Paolo Basile, Giuseppina Renzulli, Vito Angelo Giagulli
BACKGROUND: Neurofibromatosis type 1 is an autosomal dominant disorder characterized by an increased incidence of tumors, including endocrine ones. Primary hyperparathyroidism can be rarely caused by a parathyroid carcinoma; these patients are generally characterized by severe symptoms, large neck lesions and high levels of PTH and calcium. We report a case of hyperparathyroidism due to parathyroid carcinoma in a patient affected by neurofibromatosis type 1. A systematic review of literature was also conducted...
September 10, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Lutfu Hanoglu, Sultan Yildiz, Tansel Cakir, Taha Hanoglu, Burak Yulug
Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired patients is still not clear. In our study, we have scanned three with eye disease and CBS (VH+) and three patients with eye disease without CBS (VH-) using FDG-PET. Our results showed underactivity in the pons and overactivity in primary right left visual cortex and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18F-FDG PET data that was taken from the database consisting of 50 age-matched healthy adults without neuropsychiatric disorders...
August 29, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Yoshifumi Saisho
Background Despite a number of innovations in anti-diabetic drugs and substantial improvement of diabetes care, the number of people with diabetes continues to increase, suggesting further need to explore novel approaches to prevent diabetes. Type 2 diabetes (T2DM) is characterized by beta cell dysfunction and insulin resistance. However, insulin resistance, usually a consequence of obesity, is often emphasized and the role of beta cell dysfunction in T2DM is less appreciated. Objective and Results This paper summarizes recent evidence showing the importance of beta cell dysfunction in T2DM and refines the "beta cell workload hypothesis", emphasizing the importance of beta cell preservation for prevention and management of T2DM...
August 21, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Wani Aadil, Rajinder Kaur, Bashir Ahmad Ganai, Tarun Narang, Tahseena Akhtar, Iffat Hassan, Sunil Kumar
BACKGROUND: IL-10 is an important pleiotropic, immunoregulatory and anti-inflammatory cytokine which plays a significant role in the pathogenesis of psoriasis. OBJECTIVE: The aim of the present study was to determine whether the three polymorphic sites of the IL-10 gene, haplotype and serum level confer susceptibility to psoriasis. METHODS: 200 psoriatic patients and 200 controls were genotyped for three IL-10 polymorphic sites by ARMS polymerase chain reaction...
August 21, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Mina Rabiee, Abdoljalal Marjani, Safoura Khajeniazi, Mohammad Mojerloo
BACKGROUND: Cytochrome P450 2C9 (CYP450 2C9) has an important role in metabolic processes. Mutations in CYP450 2C9 genes may affect the catalytic activity of this enzyme. The aim of the present study is to assess the genetic polymorphisms of Cytochrome P450 (2C9) enzyme in Turkmen and Fars ethnic groups with type 2 diabetes compared with controls. METHODS: A total of 336 Turkmen and 336 Fars type 2 diabetic patients and 336 healthy Turkmen and Fars individuals were included in this study...
August 21, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Ahmet Gorgel, Cem Cankaya, Mehmet Tecellioglu
Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response against increased intestinal permeability due to mucosal damage are among the serological markers of Crohn's Disease. METHODS: However, this microbial seromarker was recently shown to be elevated in several autoimmune disorders such as celiac disease, autoimmune liver diseases, type 1 diabetes, and Graves' disease. Despite that fact, ASCA seropositivity in autoimmune polyglandular syndrome (APS) have never been reported before...
August 17, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Michele Iovino, Tullio Messana, Giovanni De Pergola, Emanuela Iovino, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
Bakground and objective: The sleep-wake cycle is characterized by a circadian rhythm involving neurotransmitters and neurohormones that are released from brainstem nuclei and hypothalamus. Aim of this review is to analyze the role played by central neural pathways, neurotrasmitters and neurohormones in the regulation of vigilance states. METHODS: We analyzed the literature identifying relevant articles dealing with central neural pathways, neurotrasmitters and neurohormones involved in the control of wakefulness and sleep...
August 15, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Franca Dicuonzo, Stefano Purciariello, Aurora De Marco, Edoardo Guastamacchia, Vicenzo Triggiani
BACKGROUND AND OBJECTIVE: giant pituitary adenomas (GPAs) are benign tumours with a diameter ≥ 4 cm [1]. They can cause symptoms and signs due to the possible hyper-secretion of one or more pituitary hormones, and involvement of the surrounding structures whereas the compression of the pituitary itself can lead to hypopituitarism. METHODS: we report on a young woman with acromegaly due to an inoperable giant GH-secreting pituitary adenoma extending to right cavernous sinus, right orbital cavity, ethmoid, right maxillary sinus, sphenoid sinus, clivus and right temporal fossa, in which medical treatment with Octreotide-LAR was able to promptly relieve headache and bilateral hemianopsia due to optic chiasm involvement, improve acromegaly symptoms and, over the time, control tumor expansion, improving fertility and therefore allowing the patient to become pregnant...
August 7, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Elsaid Wasfy, Galal Elkassas, Sally Elnawasany, Kariman Elkasrawy, Sherief Abd-Elsalam, Shaimaa Soliman, Rehab Badawi
Background& Aims: Esophageal varices (EV) are a major complication of portal hypertension in cirrhotic patients. Screening is essential for all patients with cirrhosis. Performing non-invasive methods for screening is a cost-effective and time-saving measure. The aim of this work is to evaluate whether insulin resistance (IR) assessed by HOMA-IR score can predict the presence of EV or not. METHODS: This cross-sectional study was carried out on sixty Egyptian cirrhotic HCV patients divided into 3 groups: Group I: 20 cirrhotic patients without esophageal varices, Group II: 20 cirrhotic patients, with small esophageal varices and Group III: 20 cirrhotic patients with large esophageal varices...
August 3, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Anoop Kumar, Ruchika Sharma, Divya Rana, Neelima Sharma
BACKGROUND AND OBJECTIVE: α-Tocopherol is the active form of vitamin E which have various biological functions. However, the exact molecular mechanism of its action is not fully understood. Thus, the main objective of the current study is to determine the contribution of α-tocopherol in counteraction of the apoptogenic signaling pathways induced by deltamethrin in murine thymocytes and splenocytes. METHODS AND RESULTS: Deltamethrin (25 µM) induces apoptosis at 18 h through activation of reactive oxygen species, caspases and depletion of glutathione in thymocytes and splenocytes...
August 1, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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