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PPAR Research

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https://www.readbyqxmd.com/read/29686698/high-glucose-induces-autophagy-through-ppar-%C3%AE-dependent-pathway-in-human-nucleus-pulposus-cells
#1
Chang Jiang, Shuhao Liu, Yuanwu Cao, Hongping Shan
Diabetes mellitus is a multiorgan disorder affecting many types of connective tissues, including bone and cartilage. High glucose could accelerate the autophagy in nucleus pulposus (NP) cells. In our present study, we investigated whether peroxisome proliferator-activated receptor γ (PPAR- γ ) pathway is involved into autophagy regulation in NP cells under high glucose condition. After NP cells were treated with different high glucose concentrations for 72 hours, the rate of autophagy increased. Moreover, the levels of PPAR γ , Beclin-1, and LC3II were significantly increased and p62 was significantly decreased compared to control group...
2018: PPAR Research
https://www.readbyqxmd.com/read/29686697/ppar-%C3%AE-antagonizes-hypoxia-induced-activation-of-hepatic-stellate-cell-through-cross-mediating-pi3k-akt-and-cgmp-pkg-signaling
#2
Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu
Background and Aims: Accumulating evidence reveals that PPAR γ plays a unique role in the regulation of hepatic fibrosis and hepatic stellate cells (HSCs) activation. This study was aimed at investigating the role of PPAR γ in hypoxia-induced hepatic fibrogenesis and its possible mechanism. Methods: Rats used for CCl4-induced hepatic fibrosis model were exposed to hypoxia for 8 hours each day. Rats exposed to hypoxia were treated with or without the PPAR γ agonist rosiglitazone...
2018: PPAR Research
https://www.readbyqxmd.com/read/29599799/peroxisome-proliferator-activated-receptor-%C3%AE-and-pgc-1-%C3%AE-in-cancer-dual-actions-as-tumor-promoter-and-suppressor
#3
REVIEW
Seong-Hoon Yun, Sang-Heum Han, Joo-In Park
Peroxisome proliferator-activated receptor γ (PPAR γ ) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism. PPAR γ coactivator-1 α (PGC-1 α ), initially identified as a PPAR γ -interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis. The role of PGC-1 α in diabetes, neurodegeneration, and cardiovascular disease is particularly well known...
2018: PPAR Research
https://www.readbyqxmd.com/read/29552030/vascular-remodeling-oxidative-stress-and-disrupted-ppar-%C3%AE-expression-in-rats-of-long-term-hyperhomocysteinemia-with-metabolic-disturbance
#4
Yajing Huo, Xuqing Wu, Jing Ding, Yang Geng, Weiwei Qiao, Anyan Ge, Cen Guo, Jianing Lv, Haifeng Bao, Wei Fan
Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPAR γ in the coronary arteriole as a possible mechanism underlying vascular remodeling. Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks. Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured...
2018: PPAR Research
https://www.readbyqxmd.com/read/29483924/-portulaca-extract-attenuates-development-of-dextran-sulfate-sodium-induced-colitis-in-mice-through-activation-of-ppar-%C3%AE
#5
Rui Kong, Hui Luo, Nan Wang, Jingjing Li, Shizan Xu, Kan Chen, Jiao Feng, Liwei Wu, Sainan Li, Tong Liu, Xiya Lu, Yujing Xia, Yanhong Shi, Yingqun Zhou, Weigang He, Qi Dai, Yuejuan Zheng, Jie Lu
Portulaca oleracea L. is a traditional Chinese medicine, which has been used as adjuvant therapy for inflammatory bowel disease (IBD). However, the mechanism of its activity in IBD still remains unclear. Since previous studies have documented the anti-inflammatory effect of peroxisome proliferator activated receptors- γ (PPAR- γ ), Portulaca regulation of PPAR- γ in inflammation was examined in current study. Ulcerative colitis (UC) was generated by 5% dextran sulfate sodium (DSS) in mice and four groups were established as normal control, DSS alone, DSS plus mesalamine, and DSS plus Portulaca ...
2018: PPAR Research
https://www.readbyqxmd.com/read/29483923/research-advances-in-the-correlation-between-peroxisome-proliferator-activated-receptor-%C3%AE-and-digestive-cancers
#6
REVIEW
Shuqi Xu, Xuanfu Xu
Peroxisome proliferator-activated receptor- γ (PPAR γ ) is a class of ligand-activated nuclear transcription factors, which is a member of type II nuclear receptor superfamily. Previous studies demonstrate that PPAR γ is expressed in a variety of tumor tissues and is closely associated with the proliferation and prognosis of digestive system tumors by its roles in mediation of cell differentiation, induction of cell apoptosis, and inhibition of cell proliferation.
2018: PPAR Research
https://www.readbyqxmd.com/read/29358945/peroxisome-proliferator-activated-receptors-associated-with-nonalcoholic-fatty-liver-disease
#7
REVIEW
Nan Wang, Rui Kong, Hui Luo, Xiaorong Xu, Jie Lu
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin-resistant state. It is a challenge to diagnose NAFLD because many patients are asymptomatic until the later stages of disease. The most common symptoms include fatigue, malaise, and discomfort in the right upper quadrant. The major and most accurate tool to clinically diagnose NAFLD is a liver biopsy, followed by histological analysis...
2017: PPAR Research
https://www.readbyqxmd.com/read/29333153/ppar-%C3%AE-agonists-and-their-role-in-primary-cicatricial-alopecia
#8
REVIEW
Sarawin Harnchoowong, Poonkiat Suchonwanit
Peroxisome proliferator-activated receptor γ (PPAR- γ ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR- γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR- γ is highly expressed in human sebaceous glands. Disruption of PPAR- γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation...
2017: PPAR Research
https://www.readbyqxmd.com/read/29230238/fluid-retention-caused-by-rosiglitazone-is-related-to-increases-in-aqp2-and-%C3%AE-enac-membrane-expression
#9
Jinghua Xu, Mingyue Pan, Xiaoli Wang, Lishi Xu, Lanfang Li, Cheng Xu
Peroxisome proliferator activated receptor- γ (PPAR γ ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily. The decreased phosphorylation of PPAR γ due to rosiglitazone (ROS) is the main reason for the increased insulin sensitivity caused by this antidiabetic drug. However, there is no clear evidence whether the nuclear translocation of p-PPAR γ stimulated by ROS is related to fluid retention. It is also unclear whether the translocation of p-PPAR γ is associated with the change of aquaporin-2 (AQP2) and epithelial sodium channel α subunit ( α ENaC) in membranes, cytoplasm, and nucleus...
2017: PPAR Research
https://www.readbyqxmd.com/read/29225614/new-transcriptional-reporters-to-quantify-and-monitor-ppar-%C3%AE-activity
#10
Séverine A Degrelle, Hussein Shoaito, Thierry Fournier
The peroxisome-proliferator-activated-receptor- γ (PPAR γ ) is a member of the nuclear receptor superfamily that plays a critical role in diverse biological processes, including adipogenesis, lipid metabolism, and placental development. To study the activity of PPAR γ , we constructed two new reporter genes: a fluorescent GFP-tagged histone-2B (PPRE-H2B-eGFP) and a secreted nanoluciferase (PPRE-pNL1.3[secNluc]). This study demonstrates their usage to monitor PPAR γ activity in different cell types and screen for PPAR γ 's potential ligands...
2017: PPAR Research
https://www.readbyqxmd.com/read/29201040/caffeoylquinic-acid-rich-extract-of-aster-glehni-f-schmidt-ameliorates-nonalcoholic-fatty-liver-through-the-regulation-of-ppar-%C3%AE-and-adiponectin-in-apoe-ko-mice
#11
Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Jong-Min Jeong, Min Jeoung Son, Chang Bae Jin, Hyoung Ja Kim, Hong Seog Seo
Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A. glehni . Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor δ , 5' adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPAR γ coactivator 1-alpha in liver tissues increased in the groups treated with A...
2017: PPAR Research
https://www.readbyqxmd.com/read/29181019/crosstalk-between-the-androgen-receptor-and-ppar-gamma-signaling-pathways-in-the-prostate
#12
REVIEW
Emuejevoke Olokpa, Patrice E Moss, LaMonica V Stewart
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical roles in the regulation of normal biological processes and several disease states. Of the nuclear receptors expressed within the prostate, the androgen receptor (AR) promotes the differentiation of prostatic epithelial cells and stimulates production of enzymes needed for liquefaction of semen. Multiple forms of AR also promote the growth of both early and late stage prostate cancers. As a result, drugs that target the AR signaling pathway are routinely used to treat patients with advanced forms of prostate cancer...
2017: PPAR Research
https://www.readbyqxmd.com/read/29093735/myocardial-expression-of-ppar-%C3%AE-and-exercise-capacity-in-patients-after-coronary-artery-bypass-surgery
#13
Izabela Wojtkowska, Tomasz A Bonda, Jadwiga Wolszakiewicz, Jerzy Osak, Andrzej Tysarowski, Katarzyna Seliga, Janusz A Siedlecki, Maria M Winnicka, Ryszard Piotrowicz, Janina Stępińska
Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPAR γ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was 397 ± 85 m versus 420 ± 93 m in non-HF...
2017: PPAR Research
https://www.readbyqxmd.com/read/29056962/chiglitazar-preferentially-regulates-gene-expression-via-configuration-restricted-binding-and-phosphorylation-inhibition-of-ppar-%C3%AE
#14
De-Si Pan, Wei Wang, Nan-Song Liu, Qian-Jiao Yang, Kun Zhang, Jing-Zhong Zhu, Song Shan, Zhi-Bin Li, Zhi-Qiang Ning, Laiqiang Huang, Xian-Ping Lu
Type 2 diabetes mellitus is often treated with insulin-sensitizing drugs called thiazolidinediones (TZD), which improve insulin resistance and glycemic control. Despite their effectiveness in treating diabetes, these drugs provide little protection from eminent cardiovascular disease associated with diabetes. Here we demonstrate how chiglitazar, a configuration-restricted non-TZD peroxisome proliferator-activated receptor (PPAR) pan agonist with moderate transcription activity, preferentially regulates ANGPTL4 and PDK4 , which are involved in glucose and lipid metabolism...
2017: PPAR Research
https://www.readbyqxmd.com/read/28819354/mediating-roles-of-ppars-in-the-effects-of-environmental-chemicals-on-sex-steroids
#15
REVIEW
Qiansheng Huang, Qionghua Chen
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of reproductive disorders receive great concern. Various kinds of exogenous chemicals, especially environmental pollutants, exert their adverse impact on the reproductive system through disturbing the PPAR signaling pathway...
2017: PPAR Research
https://www.readbyqxmd.com/read/28781590/association-of-ppar-alpha-intron-7-g-c-ppar-gamma-2-pro12ala-and-c161t-polymorphisms-with-serum-fetuin-a-concentrations
#16
Bernadett Márkus, Krisztián Vörös, Dorina Supák, Zsolt Melczer, Károly Cseh, László Kalabay
BACKGROUND: Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS: We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS: The PPARα intron 7 G/C polymorphism was studied in cohort 1 (79 reference individuals, 165 postinfarction patients). The two PPARγ polymorphisms were investigated in cohort 2 (162 reference individuals, 165 postinfarction patients)...
2017: PPAR Research
https://www.readbyqxmd.com/read/28740504/2-4-thiazolidinedione-treatment-improves-the-innate-immune-response-in-dairy-goats-with-induced-subclinical-mastitis
#17
Fernanda Rosa, Johan S Osorio, Erminio Trevisi, Francisco Yanqui-Rivera, Charles T Estill, Massimo Bionaz
Mastitis is a major disease in dairy cows resulting in significant economic losses. In vitro works suggest that ruminants peroxisome proliferator-activated receptor gamma (PPARγ) can aid in improving the response to mastitis and can control milk fat synthesis. The objectives of the present experiment were to test if treatment with the putative PPARγ agonist 2,4-thiazolidinedione (TZD) improves (1) the response to subclinical mastitis and (2) milk fat production. Lactating goats received daily injections of 8 mg/kg BW of TZD or saline for 3 weeks...
2017: PPAR Research
https://www.readbyqxmd.com/read/28659972/discovery-of-novel-insulin-sensitizers-promising-approaches-and-targets
#18
REVIEW
Yadan Chen, Haiming Ma, Dasheng Zhu, Guowei Zhao, Lili Wang, Xiujuan Fu, Wei Chen
Insulin resistance is the undisputed root cause of type 2 diabetes mellitus (T2DM). There is currently an unmet demand for safe and effective insulin sensitizers, owing to the restricted prescription or removal from market of certain approved insulin sensitizers, such as thiazolidinediones (TZDs), because of safety concerns. Effective insulin sensitizers without TZD-like side effects will therefore be invaluable to diabetic patients. The specific focus on peroxisome proliferator-activated receptor γ- (PPARγ-) based agents in the past decades may have impeded the search for novel and safer insulin sensitizers...
2017: PPAR Research
https://www.readbyqxmd.com/read/28638404/puerarin-protects-against-cardiac-fibrosis-associated-with-the-inhibition-of-tgf-%C3%AE-1-smad2-mediated-endothelial-to-mesenchymal-transition
#19
Ya-Ge Jin, Yuan Yuan, Qing-Qing Wu, Ning Zhang, Di Fan, Yan Che, Zhao-Peng Wang, Yang Xiao, Sha-Sha Wang, Qi-Zhu Tang
BACKGROUND: Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics. But little is known about its effects on regulating cardiac fibrosis. METHODS: Mice were subjected to transverse aorta constriction (TAC) for 8 weeks; meanwhile puerarin was given 1 week after TAC. Cardiac fibrosis was assessed by pathological staining. The mRNA and protein changes of CD31 and vimentin in both animal and human umbilical vein endothelial cells (HUVECs) models were detected...
2017: PPAR Research
https://www.readbyqxmd.com/read/28529521/the-interplay-between-metabolism-ppar-signaling-pathway-and-cancer
#20
EDITORIAL
Daniele Fanale, Valeria Amodeo, Stefano Caruso
No abstract text is available yet for this article.
2017: PPAR Research
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