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Hospital Practice (Minneapolis)

Zeynep Ture, Emine Alp
Invasive candida infections are the most important causes of invasive nosocomial infections in intensive care units and in risky groups such as immunosuppressed patients. These infections lead to undesirable consequences such as increased morbidity and mortality in patients, prolongation of hospital stay, and increased hospital costs. In recent years, the incidence of non-albicans Candida spp.'s has increased. Unfortunately, some of these species are naturally resistant to first line antifungals. In addition, biofilm formation on the central venous catheter and invasive devices may cause treatment failure...
August 13, 2018: Hospital Practice (Minneapolis)
E Carlos Rodriguez-Merchan
INTRODUCTION: Knee osteoarthritis (OA) is one of the preeminent musculoskeletal illnesses in the adult population. AIM: To investigate the role of intra-articular injections of joint fat-derived mesenchymal stem cells (MSCs) in knee OA. METHODS: A Cochrane Library and PubMed (MEDLINE) search related to the role of intra-articular injections of joint fat-derived MSCs in knee OA was analyzed. RESULTS: Experimental and clinical studies on intra-articular injections of joint fat-derived MSCs have provided satisfactory results (pain relief) in the short term...
August 11, 2018: Hospital Practice (Minneapolis)
Antionette Terblanche, Johanna Catharina Meyer, Brian Godman, Robert Stanley Summers
BACKGROUND AND AIMS: Under-reporting of adverse drug reactions (ADRs) by health care professionals (HCPs) is a worldwide problem. Spontaneous reporting in hospitals is scarce and several obstacles have been identified. Improved hospital-based reports could make important contributions to future care. Consequently, the objective of this study was to develop, implement and evaluate a structured pharmacist-driven pharmacovigilance (PV) system for in-patient ADR reporting in a leading public hospital in South Africa, for future use in South Africa and wider...
August 9, 2018: Hospital Practice (Minneapolis)
Antonio M Esquinas, Habib M R Karim, Guy W Soo Hoo
No abstract text is available yet for this article.
August 9, 2018: Hospital Practice (Minneapolis)
E Carlos Rodriguez-Merchan
INTRODUCTION: Tobacco use is related to augmented morbidity and mortality. People who smoke heavily before orthopedic surgery may have more nonmedical complications than nonsmokers. Therefore, all orthopedic surgery patients should be screened for tobacco use. AIM: To investigate the musculoskeletal effects of perioperative smoking. METHODS: A narrative review of the literature on the topic was performed. RESULTS: Orthopedic perioperative complications of smoking include impaired wound healing, augmented infection, delayed and/or impaired fracture union and arthrodesis, and worst total knee and hip arthroplasty results...
August 9, 2018: Hospital Practice (Minneapolis)
Joana Alves, Pedro Palma, Daniela Azevedo, Jordi Rello
Invasive fungal infections are a common life-threatening disease and a major cause of morbidity, particularly in patients with malignancies, and Candida spp. is the most common isolated fungi in bloodstream. Candidemia is the focus of this review, which covers an approach to diagnosis and treatment, with an emphasis on patients with malignancies. Acute leukemia, lymphoma or myelodysplastic syndrome, are the most common hematological malignancies associated with candidemia, while among solid tumors gastrointestinal cancer has the majority of fungemia cases...
August 6, 2018: Hospital Practice (Minneapolis)
Joseph F Dasta, Shirin Sundar, Sandra Chase, Melissa Lingohr-Smith, Jay Lin
OBJECTIVES: To estimate the cost difference associated with tolvaptan treatment vs. fluid restriction (FR) among hospitalized patients with heart failure (HF) and hyponatremia (HN) based on a real-world registry of HN patients. METHODS: An Excel-based economic model was developed to evaluate the cost impact of tolvaptan treatment vs. FR. Model input for hospital length of stay (LOS) was based on published data from the Hyponatremia Registry (HNR). Based on HNR data, tolvaptan-treated patients had a 2-day (median) shorter LOS compared to FR...
August 2, 2018: Hospital Practice (Minneapolis)
Pratyusha Vadagam, Khalid M Kamal
Objective To determine patient, hospital, and clinical characteristics associated with the length of stay (LOS), total hospital charges, and total hospital costs in cystic fibrosis (CF). Methods Hospital discharge records with primary and secondary diagnoses of CF were identified from the 2012 Kids' Inpatient Database (KID) consisting of inpatient records of ages 0-20 years; and 2012 National Inpatient Sample (NIS) consisting of inpatient records of ages 21 and above. Both the databases are part of the Healthcare Cost and Utilization Project (HCUP)...
August 1, 2018: Hospital Practice (Minneapolis)
Katelyn R Keyloun, David J Weber, Betsey M Gardstein, Ariel Berger, Patrick Gillard, Michael L Ganz
OBJECTIVES: We estimated the total US hospital costs associated with acute bacterial skin and skin structure infection (ABSSSI) admissions as well as the admissions that may have been potential candidates for outpatient parenteral antimicrobial therapy (OPAT). METHODS: We assessed inpatient admissions for ABSSSI from the Premier database (2011-2014), focusing on all admissions of adults with length of stay (LOS) ≥1 days and a primary diagnosis of erysipelas, cellulitis/abscess, or wound infection...
August 1, 2018: Hospital Practice (Minneapolis)
Sarah Eisho, Nouran M Salem, Janet L Hoffman, John M Koerber, Maureen A Smythe
OBJECTIVES: To identify patient characteristics, bleed management, and bleed outcomes in patients experiencing an apixaban major bleeding event and to identify opportunities to improve the safe use of apixaban. METHODS: This retrospective single health-system study identified apixaban patients experiencing a major bleeding event between January 2013 and May 2016 through electronic medical record review. Patient characteristics, bleed management, and outcomes were extracted in those with a confirmed major bleed assessed by the International Society on Thrombosis and Haemostasis criteria...
July 30, 2018: Hospital Practice (Minneapolis)
Godfrey Mutashambara Rwegerera, Onkabetse Julia Molefe-Baikai, Anthony Masaka, Meshack Shimwela, Yordanka Pina Rivera, Taibat Aderonke Oyewo, Brian B Godman, Amos Massele, Dereje Habte
BACKGROUND AND AIMS: Diabetes mellitus (DM) is one of the most common contributors of chronic kidney disease (CKD). The epidemiology of CKD, a concern among patients with DM, has not been studied in Botswana. The aim of this study was to estimate its prevalence among these patients to provide future guidance to both government personnel and physicians. METHODS: Observational cross-sectional study in a leading clinic in Botswana. Demographic and clinical data were obtained from patients through interviews and from their notes using a standard questionnaire...
July 30, 2018: Hospital Practice (Minneapolis)
Saswat Panda, Mark Connolly, Manuel G Ramirez
OBJECTIVES: Inguinal hernias of the abdominal wall are common accounting for 75% of all hernia defects. They can be treated with laparoscopic surgery using a transabdominal preperitoneal (TAPP) approach. However, in surgery there is some contention on how to conclude the hernia repair, as there are alternatives of using fibrin sealant (FS) or tack screws for fixation of a mesh implant over the defect in the abdominal wall. In this study, we evaluate the economic consequences of using FS vs...
July 25, 2018: Hospital Practice (Minneapolis)
Manuel G Ramirez, Harel Deutsch, Nitin Khanna, Donald Cheatem, Dongyan Yang, Erik Kuntze
OBJECTIVE: Flowable agents such as Floseal® (F) are often reserved as adjuncts to non-flowable agents (i.e. gelatin (G) sponges and thrombin (T)) when bleeding is not sufficiently controlled. Based on their perceived positive impact, it is postulated that flowable agents alone may result in better clinical and resource utilization outcomes. Clinical and health-care utilization outcomes were compared in this retrospective analysis of spine surgery cases with charges for Floseal only (FO) and F + G/T...
July 23, 2018: Hospital Practice (Minneapolis)
Matthew A Bartlett, Dennis M Bierle, Rayya A Saadiq, Karen F Mauck, Paul R Daniels
Venous thromboembolism (VTE) management is rapidly evolving and staying up-to-date is challenging. We identified the most practice-informing articles published in 2017 relevant to the nonspecialist provider managing VTE. We performed a systematic search of the literature (Appendix A), limiting the search to a publication date of 2017. Two reviewers screened the 2735 resulting abstracts to identify high-quality, clinically relevant publications related to VTE management. One-hundred and six full-text articles were considered for inclusion...
June 20, 2018: Hospital Practice (Minneapolis)
Wisit Cheungpasitporn, Charat Thongprayoon, Michael A Mao, Wonngarm Kittanamongkolchai, Ankit Sakhuja, Stephen B Erickson
BACKGROUND: The aim of this study was to assess the relationship between admission serum phosphate levels and in-hospital mortality in all hospitalized patients. METHODS: All adult hospitalized patients who had admission serum phosphate available between years 2009 and 2013 were enrolled. Admission serum phosphate was categorized based on its distribution into six groups (<2.5, 2.5-3.0, 3.1-3.6, 3.7-4.2, 4.3-4.8 and ≥4.9 mg/dL). The odds ratio (OR) of in-hospital mortality by admission serum phosphate, using the phosphate category of 3...
June 18, 2018: Hospital Practice (Minneapolis)
Vasilis Tsimihodimos, Anastazia Kei, Fotini Apostolou, Moses Elisaf
BACKGROUND: Visceral leishmaniasis (VL) has been associated with the increase in triglyceride (TG) levels and the decrease in high-density lipoprotein cholesterol (HDL-C) concentration. The aim of the study was to evaluate whether there is a diagnostic cut-off point in these lipid profile changes. MATERIALS AND METHODS: We included 100 patients with febrile infections. Analytically, 22 patients with VL, 18 patients with leptospirosis, 20 patients with Brucella melitensis, and 40 age- and sex-matched patients with fever and proven bacteremia (endocarditis and pyelonephritis)...
June 6, 2018: Hospital Practice (Minneapolis)
Chan Yeu Pu, Nancy Quesada, Richard Nunez Lopez, Karmapath Aryal, Aiman Tulaimat
BACKGROUND: The diagnosis of COPD in patients hospitalized for AECOPD can be confirmed by spirometry showing obstruction or radiographs showing emphysema. The evidence for COPD is sometimes absent or contradicts this diagnosis. The inaccurate attribution of the exacerbation to COPD can lead to suboptimal care and worse outcome. OBJECTIVES: We determined if the presence of tests that confirm the diagnosis of COPD has any implications on the course of the hospitalization and readmission rate...
May 28, 2018: Hospital Practice (Minneapolis)
Olayinka O Ogunleye, Joseph O Fadare, Adesola F Yinka-Ogunleye, Bene D Anand Paramadhas, Brian Godman
OBJECTIVES: The problem of antimicrobial resistance (AMR) has assumed pandemic dimensions especially among low-and middle-income countries such as Nigeria. Irrational use of currently available antimicrobial agents is a major contributory factor. There remains a paucity of documented information on the determinants of antibiotic prescribing among physicians in Nigeria to guide future strategies to reduce AMR. This study therefore aimed to investigate the patterns and determinants of antibiotic prescribing among doctors in a tertiary hospital in Nigeria as the first step to improve future antibiotic use in hospitals...
May 21, 2018: Hospital Practice (Minneapolis)
(no author information available yet)
No abstract text is available yet for this article.
May 7, 2018: Hospital Practice (Minneapolis)
Caleb Okoth, Sylvia Opanga, Faith Okalebo, Margaret Oluka, Amanj Baker Kurdi, Brian Godman
BACKGROUND AND AIMS: A substantial amount of antibiotic use in hospitals may be inappropriate, potentially leading to the development and spread of antibiotic resistance, adverse effects, mortality and increased hospital costs. The objective was to assess current patterns of antibiotic use in a leading referral hospital in Western Kenya. This would lead to the identification of opportunities for quality improvement in this hospital and others across Kenya. METHODOLOGY: A point prevalence survey was carried out with data abstracted principally from patient medical records supplemented by interviews from physicians when needed...
April 27, 2018: Hospital Practice (Minneapolis)
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