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Cutaneous and Ocular Toxicology

Leyla Baykal Selçuk, Deniz Aksu Arıca, Hanife Baykal Şahin, Savas Yaylı, Sevgi Bahadır
BACKGROUND/OBJECTIVE: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit in the skin. Isotretinoin is a synthetic vitamin A derivative regarded as the most effective agent in the treatment of acne. There have recently been increasing reports of adverse effects of isotretinoin on the skeletal system. Our aim in this study was to evaluate the rheumatic side-effects triggered by this drug, and particularly the prevalence of sacroiliitis. MATERIALS AND METHODS: Seventy-three patients receiving isotretinoin due to moderate or severe acne vulgaris were included...
October 20, 2016: Cutaneous and Ocular Toxicology
Gonce Elcin, Duygu Gülseren, Miyase Bayraktar, Serdar Gunalp, Timur Gurgan
Autoimmune estrogen dermatitis is a cyclical cutaneous eruption that occurs premenstrually and rapid resolution of the eruptions within a few days of menstrual cycles. The disorder has variable clinical manifestations consisting of macules, papules, vesicles, urticarial lesions, bullae, eczematous plaques, and erythema multiforme-like lesions. Herein, we present a case of a 30-year-old woman with attacks of edema and erosions involving the oral and genital mucosal sites on every first day of her menstruation period...
October 11, 2016: Cutaneous and Ocular Toxicology
Ayse Dolar Bilge, Fariz Sadigov, Senem Salar-Gomceli
BACKGROUND: Botulinum toxin A (BTX) has been widely used for a variety of facial esthetic procedures within the last couple of decades. Efficacy and safety of BTX for facial rejuvenation has been extensively studied in multiple randomized prospective controlled trials. Focal weakness is among the most commonly reported adverse effects. Adverse reactions tend to occur most commonly due to errors in dosing formulation and errors with the techniques of the application. No serious long-term complications have been reported...
September 26, 2016: Cutaneous and Ocular Toxicology
Fadime Kilinc, Ayse Akbas, Sertac Sener, Akın Aktaş
BACKGROUND: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Up to now, not many atypical forms are reported. OBJECTIVE: To determine the clinical characteristics of patients with atypical pityriasis rosea. METHODS: A total of 27 cases, diagnosed as atypical PR by clinical and/or histopathological examination and applied to the outpatient clinic of dermatology department between the years 2007 and 2015 were analyzed retrospectively...
September 26, 2016: Cutaneous and Ocular Toxicology
Artur Beberok, Dorota Wrześniok, Zuzanna Rzepka, Jakub Rok, Marcin Delijewski, Michał Otręba, Michalina Respondek, Ewa Buszman
PURPOSE: Fluoroquinolones are one of the most commonly prescribed classes of antibiotics. However, their use is often connected with high risk of phototoxic reactions that lead to various skin or eye disorders. The aim of this study was to examine the effect of ciprofloxacin, lomefloxacin and moxifloxacin, fluoroquinolone derivatives with different phototoxic potential, on the viability and melanogenesis in melanocytes. MATERIALS AND METHODS: Normal human epidermal melanocytes, dark pigmented (HEMn-DP) were used as an in vitro model system...
August 30, 2016: Cutaneous and Ocular Toxicology
Havva Ozge Keseroglu, Gamze Taş-Aygar, Müzeyyen Gönül, Ozay Gököz, Sibel Ersoy-Evans
Bullous pemfigoid (BP), an autoimmune disorder, can also be induced by some medications. Vildagliptin is a new drug used to treat diabetes mellitus (DM). Recently, a few cases of vildagliptin-induced BP have been described in the literature. We report a patient with BP in which vildagliptin was thought to be as a possible causative agent. The awareness of BP development risk during gliptin therapy can prevent unnecessary usage of systemic drugs with serious side effects.
August 11, 2016: Cutaneous and Ocular Toxicology
Diana Monteiro, Paula Egipto, Julia Barbosa, Ricardo Horta, Jose Amarante, Pedro Silva, Alvaro Silva
CONTEXT: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) corresponds to a rare and acute life-threatening mucocutaneous reactions characterized by extensive necrosis and epidermal detachment. There are no efficacious pharmaceutical interventions proven through large clinical trials. OBJECTIVE: We sought to study clinical cases admitted in our institution in order to determine which drugs and medical comorbidities or treatments impacted the mortality...
August 3, 2016: Cutaneous and Ocular Toxicology
Darren D Lynn, Leonid M Zukin, Robert Dellavalle
CONTEXT: Diphoterine, developed by the French company Prevor, is a polyvalent, chelating, amphoteric and slightly hypertonic solution used in the management of chemical cutaneous and ocular burns. While used extensively in Europe and Canada, it is has not been approved by the United States Occupational Safety and Health Administration (OSHA) as an alternative to the water-rinse method due to a lack of evidence of its safety and efficacy on human subjects. An unbiased and extensive systematic review was undertaken in order to better understand Diphoterine's safety and efficaciousness on humans...
August 3, 2016: Cutaneous and Ocular Toxicology
Neera Tewari-Singh, Claire R Croutch, Richard Tuttle, Dinesh G Goswami, Rama Kant, Eric Peters, Tara Culley, David A Ammar, Robert W Enzenauer, J Mark Petrash, Robert P Casillas, Rajesh Agarwal
Ocular injury by lewisite (LEW), a potential chemical warfare and terrorist agent, results in edema of eyelids, inflammation, massive corneal necrosis and blindness. To enable screening of effective therapeutics to treat ocular injury from LEW, useful clinically-relevant endpoints are essential. Hence, we designed an efficient exposure system capable of exposing up to six New-Zealand white rabbits at one time, and assessed LEW vapor-induced progression of clinical ocular lesions mainly in the cornea. The right eye of each rabbit was exposed to LEW (0...
December 2016: Cutaneous and Ocular Toxicology
Aysun Sanal Dogan, Evrim Onder, Ata Turker Arikok, Tolga Bicer, Canan Gurdal
CONTEXT: Pterygium is the fibrovascular growth of the limbal conjunctiva over cornea. This proliferative nature might have a pathogenesis associated with tight junction proteins. OBJECTIVE: To investigate the tight junction protein claudin-1 expressions in pterygium with respect to normal conjunctiva. MATERIALS AND METHODS: This retrospective study included 28 patients who underwent pterygium surgery with autograft. Claudin-1 expressions were immunohistochemically evaluated in normal and lesional conjunctiva of the same eye...
December 2016: Cutaneous and Ocular Toxicology
Sung Uk Baek, In Won Park, Wool Suh
PURPOSE: To assess the long-term intraocular pressure (IOP) changes after the intravitreal injection of bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for treatment of age-related macular degeneration (AMD) and diabetic macular edema (DME) patients and evaluate the correlation factors. MATERIAL AND METHODS: Patients with neovascular AMD or DME underwent treat-and-extended anti-VEGF regimen in one eye and followed more than 12 months were enrolled in this study...
December 2016: Cutaneous and Ocular Toxicology
Asli Tanrivermis Sayit, Kerim Aslan, Muzaffer Elmali, Inci Gungor
We report a 52-year-old man with methanol intoxication who showed optic nerve damage as assessed by magnetic resonance imaging (MRI). He was admitted to the hospital with blurred vision after the consumption of alcohol (600-700 ml of cologne). He was treated with intravenous ethanol, NaHCO3 and hemodialysis. On admission, a brain and orbital MRI was performed. Bilateral mild contrast enhancement was detected on the contrast-enhanced images in the retrobulbar segment of the optic nerves (RBONs). Also, diffusion-weighted images showed restricted diffusion in the RBONs...
December 2016: Cutaneous and Ocular Toxicology
Emin Ozlu, Ayse Serap Karadag, Seyma Ozkanli, Serpil Oguztuzun, Murat Kilic, Ebru Zemheri, Ozge Akbulak, Necmettin Akdeniz
CONTEXT: Recent studies have shown that tolls like receptors (TLRs) and antimicrobial peptides (hBD-1, cathelicidin) play an important role in the pathogenesis of acne vulgaris (AV). OBJECTIVE: To evaluate and report the expression of TLR-2, TLR-4, hBD-1 and cathelicidin in different regions of skin in AV. PARTICIPANTS: This study was performed in 80 patients with AV and a control group of 20 healthy individuals. MATERIAL AND METHODS: Skin biopsies were performed from 20 papular, 20 pustular, 20 comedonal and 20 nodular lesions of patients and 20 healthy volunteers...
December 2016: Cutaneous and Ocular Toxicology
Levent Çinar, Demet Kartal, Can Ergin, Huseyin Aksoy, Mert Ali Karadag, Turgut Aydin, Elif Cinar, Murat Borlu
BACKGROUND/OBJECTIVE: Acne vulgaris is one of the most common diseases of the youth. Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of acne. Isotretinoin has some well-known side effects. Besides these, there is a suspicion whether it causes infertility or not. In this study, we aimed to evaluate the effects of systemic isotretinoin on male fertility. METHODS: Eighty one male patients, who were older than 18 years of age, and had severe or refractory acne vulgaris were included in the study...
December 2016: Cutaneous and Ocular Toxicology
Sungjin Kim, Hyelim Park, Hyewon Park, Boyoung Joung, Eunkyung Kim
CONTEXT: Adverse health effects of ambient particulate matter (PM) have been demonstrated in humans, mostly in terms of respiratory and cardiovascular events. However, whether ambient particle could affect the eyes had not been fully revealed. OBJECTIVE: This study investigated the effect of acute respiratory exposure to PM on eyes. METHODS: Diesel exhaust product (DEP) of 200 mg/l was given endotracheally in Sprague-Dawley rats for 1 h (n = 12) and compared to normal control (n = 4)...
December 2016: Cutaneous and Ocular Toxicology
Denise Gutshall, Shaoying Zhou, Baiyang Wang, Miranda A Farage, Anne E Hochwalt
CONTEXT: We have developed a line of products designed to better meet the overall needs of women suffering from urinary incontinence. The products are more discrete and contain a unique odor neutralizing technology (ONT). OBJECTIVE: This paper describes the overall skin compatibility program for this product line in which the new products were compared to negative controls and/or commercially marketed reference products with an established history of safe use. MATERIALS AND METHODS: Test products consisted of several product forms (light pads/pantiliners, moderate pads, briefs and taped diapers) with ONT and having various degrees of protection...
December 2016: Cutaneous and Ocular Toxicology
Roberta Bertani, Paolo Sgarbossa, Flavio Pendolino, Giangiacomo Facchin, Rossella Snenghi
Hair highlights are quite common procedures carried out in hair salons by using a mixture of a lightening powder containing persulfates with a suspension containing hydrogen peroxide: a representative case of chemical scalp burns is described as a consequence of this treatment. The aim of the paper is to demonstrate the strict relationship between the scalp damage and the commercial products used in a case of hair highlighting. The results of some chemical analyses have been reported, showing, in particular, that the chemical reactivity of the mixture changes in the time, thus strongly suggesting that the procedure for the application of the mixture is critical for the occurrence of possible accidents...
December 2016: Cutaneous and Ocular Toxicology
Mehmet Serdar Dervişoğulları, Yüksel Totan, Aslıhan Yüce, Ali Ender Kulak
OBJECTIVE: To explore ocular changes in healthy people after caffeine consumption. METHODS: This prospective observational study was carried out with students of the Turgut Özal University Medical Faculty from May 15 to 15 December 2014. Enrolled in the study were 17 healthy subjects (n = 17 eyes), with a median age of 24 (IQR 1), ranging between 21 and 26 years. The control group (6 females, 11 males) aged between 23 and 28 (median 25 years [IQR 4.75]). For study, one eye from each participant was randomly selected...
December 2016: Cutaneous and Ocular Toxicology
Zeynep Dadaci, Mufide Oncel, Nursen Oncel Acir, Emel Sahin, Mehmet Borazan
OBJECTIVE: To evaluate oxidative stress parameters and serum magnesium (Mg) levels in patients with seasonal allergic conjunctivitis (SAC) during the pollen season. METHODS: This observational cross-sectional study involved 35 patients with SAC without any other ocular and systemic diseases, and 38 consecutive, age- and sex-matched healthy subjects. Serum malondialdehyde (MDA), adjusted ischemia modified albumin (IMA), and Mg levels were quantified, and the results were compared between the groups...
December 2016: Cutaneous and Ocular Toxicology
Irini P Chatziralli, George P Theodossiadis, Efstratios Parikakis, Ioannis Datseris, Panagiotis Theodossiadis
OBJECTIVE: The purpose of this study was to evaluate the safety of intravitreal ocriplasmin prospectively, reporting potential complications in patients with vitreomacular traction (VMT) alone or associated with macular hole (MH). MATERIALS AND METHODS: Participants in this prospective, multicenter study, were 24 patients with VMT (17 with VMT alone and seven with MH combined with VMT). All patients were treated with a single ocriplasmin injection and followed-up prospectively at baseline, day 7, 28 and the last examination of the follow-up for each patient (mean ± SD: 64...
December 2016: Cutaneous and Ocular Toxicology
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