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Cutaneous and Ocular Toxicology

Lan-Hsin Chuang, An-Lun Wu, Nan-Kai Wang, Kuan-Jen Chen, Laura Liu, Yih-Shiou Hwang, Ling Yeung, Wei-Chi Wu, Chi-Chun Lai
PURPOSE: To perform preclinical studies to determine the efficacy and safety of anthocyanins as stains for the internal limiting membrane (ILM) of the eye. MATERIALS AND METHODS: Cyanidin (Cya), delphinidin (Del), luteolinidin (Lut), peonidin (Peo), and pelargonidin (Pel) were evaluated. These natural dyes were used to stain the lens capsule and ILM of pig eyes. The effects of these dyes on retinal cell viability was determined using a water-soluble tetrazolium salt assay, and oxidative stress was measured in vitro...
May 9, 2018: Cutaneous and Ocular Toxicology
Zhan Song, Ting-Jun Fan
PURPOSE: Tetracaine is a local anesthetic widely used in ocular diagnosis and ophthalmic surgery and may lead to some adverse effects and complications at a clinical dose. To assess the cytotoxicity and molecular toxicity mechanisms of tetracaine, we used human corneal stromal (HCS) cells as an in vitro model to study the effects of tetracaine on HCS cells. MATERIALS AND METHODS: The cytotoxicity of tetracaine on HCS cells was investigated by examining the changes of cell growth, morphology, viability and cell cycle progressing when HCS cells were treated with tetracaine at concentrations from 10 g/L to 0...
May 9, 2018: Cutaneous and Ocular Toxicology
Jason E Ham, Paul Siegel, Howard Maibach
Formaldehyde allergic contact dermatitis (ACD) may be due to products with free formaldehyde or formaldehyde-releasing agents, however, assessment of formaldehyde levels in such products is infrequently conducted. The present study quantifies total releasable formaldehyde from "in-use" products associated with formaldehyde ACD and tests the utility of commercially available formaldehyde spot test kits. Personal care products from 2 patients with ACD to formaldehyde were initially screened at the clinic for formaldehyde using a formaldehyde spot test kit...
May 3, 2018: Cutaneous and Ocular Toxicology
Katarzyna Nowomiejska, Agnieszka Kiszka, Ryszard Maciejewski, Anselm Jünemann, Robert Rejdak
PURPOSE: To measure the area of central scotoma obtained with semi-automated kinetic perimetry (SKP) in patients suffering from tobacco-alcohol toxic neuropathy (TATN). METHODS: Twelve eyes of six patients with TATN were examined with SKP. Area of central scotoma was measured in square degrees (deg2 ). Additionally, static automated perimetry (SAP) within 60° was performed in each patient. RESULTS: Area of central scotoma was 41.8 deg2 for III4e isopter, 22...
April 24, 2018: Cutaneous and Ocular Toxicology
Ayşe Akbaş, Fadime Kilinç
BACKGROUND: Hyperhidrosis is a condition where the amount of sweat released to skin surface increases due to the over-active eccrine sweat glands. Hyperhidrosis causes considerable psychosocial distress in affected people. It affects the quality of life and leads to social anxiety disorders. AIMS: No study has been conducted in our country to investigate the epidemiological, clinical and laboratory data of patients with hyperhidrosis. In this study, we aimed to retrospectively investigate the clinical and demographic characteristics, causes of sweating and laboratory findings in patients treated for hyperhidrosis at our outpatient clinic and to compare these data with the literature data...
April 18, 2018: Cutaneous and Ocular Toxicology
Wu Dayang, Pang Dongbo
AIM: To explore the osmolytes expression in UVA stressed human retinal pigment epithelial cells. METHODS: Osmolyte transporters and VEGF mRNA were determined by realtime PCR. Osmolyte uptake were measured by radioimmunoassay. VEGF concentrations were determined by immunoassay and ELISA. Osmolyte transporter TAUT were silenced by siRNA technology. RESULTS: Hypertonicity accelerated osmolyte betaine uptake, myoinositol uptake and taurine uptake, compared to normotonic stress...
April 15, 2018: Cutaneous and Ocular Toxicology
Ertugrul Kilic, Mesut Ortatatli, Sermet Sezigen, Rusen Koray Eyison, Levent Kenar
Sulfur mustard (SM) is an highly toxic and vesicant chemical weapon that was used in various military conflicts several times in the history. The severity of ocular, dermal, and pulmonary symptoms that may appear following a characteristic asymptomatic period are depending on the SM concentration and exposure duration. The aim of this study is to present the clinical features and share the intensive care unit (ICU) experiences for the medical management of mustard gas victims. Thirteen Free Syrian Army soldiers near Al-Bab region of North Syria were reportedly exposed to oily blackish smoke with garlic smell due to the explosion of a trapped bomb without causing any blast or thermal effect on 26th November 2016...
April 12, 2018: Cutaneous and Ocular Toxicology
Gul Arikan, Ezgi Karatas, Banu Lebe, Ziya Ayhan, Canan Asli Utine, Oya Eren Kutsoylu, Uzeyir Gunenc, Osman Yilmaz
PURPOSE: To identify the risk of inducing ocular surface dysplasia following topical administration of 1% voriconazole eye drop. METHODS: Fourteen noninflamed healthy eyes of 14 white adult New Zealand rabbits were included in the study. The rabbits were randomly divided into two groups comprised of 7 rabbits each. Group 1 received topical 1% voriconazole and Group 2 received topical saline as the control group. In all animals, right eye was selected for the study...
April 10, 2018: Cutaneous and Ocular Toxicology
Nimet Yesim Ercalik, Serhat Imamoglu, Esra Turkseven Kumral, Nursal Melda Yenerel, Handan Bardak, Yavuz Bardak
PURPOSE: The purpose of this study was to evaluate the influence of serous retinal detachment (SRD) on the outcome of intravitreal ranibizumab (IVR) therapy in diabetic macular edema (DME). MATERIALS AND METHODS: Fifty-one eyes with cystoid macular edema (CME) and SRD (study group) and 57 eyes with only CME (control group) that received pro re nata (PRN) IVR injections during a 6-month period were retrospectively evaluated. The outcome measures included changes in the central macular thickness (CMT) and best corrected visual acuity (BCVA) and injection numbers...
April 5, 2018: Cutaneous and Ocular Toxicology
Hande Güçlü, Zeynep Banu Doganlar, Vuslat Pelitli Gürlü, Altan Özal, Ayten Dogan, Meryem Aysenur Turhan, Oguzhan Doganlar
Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer. including anal, gastrointestinal and oral cancer, as well as head and neck tumours. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain unclear. The aim of this study is to explain the possible mechanisms by which combined PF treatment results in retinal toxicity and to investigate the effects of PF on important vital signalling pathways in ARPE 19 retinal pigmented epithelial cells...
April 2, 2018: Cutaneous and Ocular Toxicology
Fehim Esen, Azer Erdagi Bulut, Ebru Toker
PURPOSE: The aim of this study was to evaluate the efficacy and safety of topical atropine and topical atropine combined with intracameral low-concentration, bisulfite-containing epinephrine treatment for the prophylaxis of intraoperative floppy iris syndrome. MATERIAL AND METHODS: Seventy-two eyes of 55 male patients who were treated with alpha-adrenergic antagonist medications for benign prostatic hyperplasia were included in this study. Standard premedication with topical cyclopentolate, phenylephrine, tropicamide and ketorolac was applied to all of the patients...
April 2, 2018: Cutaneous and Ocular Toxicology
Lihua Zhu, Jia Li, Dayang Wu, Bing Li
PURPOSE: To investigate the protective effect of beta-casomorphin-7 (β-CM-7) in oxidative stressed human lens epithelial cells (HLECs) and to explore the possible mechanism for oxidative stress in HLECs induced by high glucose. METHODS: We used HLECs to determine the effect of different concentrations of β-CM-7 on cell viability by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolimol/L bromide (MTT) assay. We used flow cytometry to determine the content of reactive oxygen species (ROS) induced by oxidative stress and a bioassay kit to determine the oxidant malondialdehyde (MDA) and antioxidant enzyme superoxide dismutase (SOD) levels...
March 27, 2018: Cutaneous and Ocular Toxicology
Ozlem Onerci Celebi, Ali Riza Cenk Celebi
PURPOSE: The effect of ocular artificial teardrop containing benzalkonium chloride (BAC) on nasal mucosa was investigated. MATERIALS AND METHODS: . There were two different treatment trial groups. Each dry eye syndrome patient received the ocular lubricant treatment four times a day in both groups (one group containing BAC the other group was not). Moistened sterile cotton-tipped applicators were placed in both nostrils and were immediately cultured prior to ocular lubricant treatment and at the end of treatment trial...
March 23, 2018: Cutaneous and Ocular Toxicology
Antonia Thinnes, Hans F Merk, Gerda Wurpts, Stefani Röseler, Sylvia Lehmann, Klaus Tenbrock, Jens Malte Baron, Galina Balakirski
BACKGROUND: Drug hypersensitivity reactions of immediate type pose a challenging problem, especially, if standard diagnostic procedures do not lead to conclusive results. The aim of this investigation is to identify, whether basophil activation test (BAT) is able to provide additional benefit in the diagnostic evaluation of immediate type drug hypersensitivity reactions to antibiotics in comparison with the routine allergological diagnostic methods. MATERIALS AND METHODS: We investigated patients, who presented to the Department of Dermatology and Allergology of the University Hospital of RWTH Aachen in Germany for diagnostic workup of type I allergic reactions to antibiotics during the period from 2009 to 2012...
March 22, 2018: Cutaneous and Ocular Toxicology
Nurdan Gamze Taşlı, Turgay Uçak, Yücel Karakurt, Ferda Keskin Çimen, Aslı Özbek Bilgin, Nezahat Kurt, Halis Süleyman
AIM: To determine the role of rutin in prevention of cisplatin induced retinal and optic nerve injury in an experimental study. MATERIALS AND METHODS: Totally 18 albino Wistar male rats were assigned into three groups, as follows: healthy controls (HC group), only cisplatin administered group for 14 days (CIS group), and rutin + cisplatin administered group for 14 days (RC group). Blood samples were obtained from animals just before the scarification. Serum malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), superoxide dismutase (SOD), interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α) levels were investigated...
March 22, 2018: Cutaneous and Ocular Toxicology
Mustafa Eren, Murat Kucukevcilioglu, Ali Hakan Durukan
PURPOSE: To examine retinal sensitivity in patients on hydroxychloroquine (HCQ) with no evidence of retinopathy. MATERIALS AND METHODS: Seventy patients on HCQ and 30 healthy control subjects were included prospectively. All subjects underwent complete ophthalmic examination including best corrected visual acuity, tonometry, colour vision testing, biomicroscopy of anterior segment, dilated fundoscopy, 10-2 visual field testing, and spectral domain optical coherence tomography...
March 20, 2018: Cutaneous and Ocular Toxicology
Reşat Duman, Ayhan Vurmaz
PURPOSE: The exact etiopathogenesis of steroid-induced cataracts (SIC) is not known. Although oxidative stress is one of the most acceptable hypotheses, the exact molecular events in steroid-induced oxidative events in the lens need to be clarified. In addition, to the best of our knowledge, the innate immune system components in SIC formation have not been studied previously. The aim of the present study was to study the oxidative system and the innate immune system components in the cataractous lenses of a developing chick embryo SIC model...
March 15, 2018: Cutaneous and Ocular Toxicology
Shou-Long Hu, Chao-Pan Zheng
As a severe photoreceptor-degenerative disease, retinitis pigmentosa (RP) is currently incurable and eventually leads to partial or complete blindness. (3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one (TIM) is a novel antioxidant isolated from the plant of Alpinia katsumadai Hayata, with protective effects on photoreceptor cells against lipoteichoic acid-induced damage through inhibiting oxidative stress. The present study was to further demonstrate whether TIM could ameliorate retinal degeneration of Pde6brd10 (rd10) mice, a mouse model of RP...
March 15, 2018: Cutaneous and Ocular Toxicology
Srijita Chakrabarti, Johirul Islam, Hemanga Hazarika, Bhaskar Mazumder, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
In the present investigation, the safety of novel combinational silver sulfadiazine-bFGF-loaded hydrogel was assured by performing acute skin irritation, sensitization, acute dermal toxicity, and eye irritation in compliance with the Organization for Economic Co-operation and Development guidelines. In the skin irritation study, placebo, test, and positive control (0.8% w/v aqueous solution of formaldehyde) were applied on New Zealand rabbits and monitored for abnormal skin responses including erythema and edema...
March 12, 2018: Cutaneous and Ocular Toxicology
Wu Dayang, Pang Dongbo
BACKGROUND: The massive uptake of organic compatible osmolytes is a self-protective response to multiple stressors. OBJECTIVE: This study aimed to determine the protective effects of the osmolyte taurine against blue light-induced apoptosis in retinal neuronal cells in vitro. METHODS: Real-time PCR was used to measure osmolyte transport. Radioimmunoassays were performed to measure osmolyte uptake. Cell Counting Kit-8 assays were conducted to measure cellular viability...
February 27, 2018: Cutaneous and Ocular Toxicology
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