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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/29298533/lysergic-acid-diethylamide-causes-photoreceptor-cell-damage-through-inducing-inflammatory-response-and-oxidative-stress
#1
Qi-Di Hu, Ling-Li Xu, Yan Gong, Guo-Hai Wu, Yu-Wen Wang, Shan-Jun Wu, Zhe Zhang, Wei Mao, Yu-Sheng Zhou, Qin-Bo Li, Jian-Shu Yuan
Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as a popular and notorious substance of abuse in various parts of the world. Its abuse could result in long-lasting abnormalities in retina and little is known about the exact mechanism. This study was to investigate the effect of LSD on macrophage activation state at non-toxic concentration and its resultant toxicity to photoreceptor cells. Results showed that cytotoxicity was caused by LSD on 661W cells after co-culturing with RAW264.7 cells...
January 3, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29237295/microrna-16-inhibits-hypoxia-induced-vascular-endothelial-growth-factor-expression-in-arpe-19-cells
#2
Huang Jianfeng, Wang Yueqian, Wang Lunan, Pan Yang, Chen Tong
PURPOSE: To investigate the effect of microRNA-16 on hypoxia-induced VEGF expression of ARPE-19 cells Methods: ARPE-19 cells were cultivated under normoxia and hypoxia state. At 0h, 12h, 24h and 48h after cultivation, the supernate of the culture medium were separated to test the VEGF secretion by ELISA, and the cells were purified to measure the expression of VEGF mRNA and microRNA-16 by qRT-PCR; microRNA-16 mimic was then transfected into ARPE-19 cells by the Hiperfect transfection reagent, a liposome transfection system...
December 13, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29233008/non-polar-compounds-of-persian-gulf-sea-cucumber-holothuria-parva-selectively-induce-toxicity-on-skin-mitochondria-isolated-from-animal-model-of-melanoma
#3
Yalda Arast, Nina Seyed Razi, Melika Nazemi, Enayatollah Seydi, Jalal Pourahmad
PURPOSE: Melanoma is a highly aggressive and deadly cancer with a poor prognosis given its drug resistance. A defect in apoptosis is one of the key mechanisms that contribute to drug resistance in Melonama. An important sea marine animal is the Holothuria parva, also known as the sea cucumber, which has various pharmacological activities. Compounds obtained from sea cucumbers have shown to have anticancer activity through induction of apoptosis singling. MATERIALS AND METHODS: In the present study, selective toxicity and apoptotic effect of three extracts of Holothuria parva (H...
December 12, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29216751/decreased-viability-and-proliferation-of-chang-conjunctival-epithelial-cells-after-contact-with-ultraviolet-light-irradiated-pollen
#4
Andrea Heidinger, Dieter Franz Rabensteiner, Jasmin Rabensteiner, Petra Kieslinger, Jutta Horwath-Winter, Edith Stabentheiner, Regina Riedl, Andreas Wedrich, Otto Schmut
Context - Contact with pollen is the major reason for the development of allergic symptoms on the ocular surface leading to a significant increase of allergic diseases worldwide. Environmental changes such as increased ultraviolet (UV) radiation and air pollution are discussed as contributory causes for this increase. Objective - We investigated the effect of ultraviolet (UV) light on the histamine content of pollen and examined if an irradiation of pollen affects the viability and proliferation of conjunctival cells...
December 7, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29171298/anti-platelet-effects-of-vitamin-supplements-in-age-related-macular-degeneration-an-in-vitro-study
#5
Marilita M Moschos, Konstantinos Laios, Sofia Androudi, Dimitrios S Ladas, Irini P Chatziralli
OBJECTIVE: The purpose of this experimental study was to investigate the role of vitamin supplements (Ocuvite, Vitalux Omega and Nutrof Total) as possible inhibitors of the onset of Age-Related Macular Degeneration (AMD). MATERIALS AND METHODS: The anti-aggregating effect of each vitamin was determined against four accumulative factors namely, Platelet Activating Factor (PAF), Adenosine diphosphate (ADP), Thrombin Receptor-activating Peptide (TRAP) and Arachidonic Acid (AA) in the Platelet Rich Plasma (PRP) of healthy volunteers...
November 24, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29171282/-3r-5-6-7-trihydroxy-3-isopropyl-3-methylisochroman-1-one-alleviates-lipoteichoic-acid-induced-photoreceptor-cell-damage
#6
En-Hui Yi, Feng Xu, Peng Li
Exposure to oxidative stress will lead to the progression of retinal degenerative diseases, and unfortunately the exact mechanisms have not been fully understood. In this study, the protective effects of (3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one (TIM) against the lipoteichoic acid (LTA)-induced cell damage in mouse photoreceptor-derived 661W cells were investigated. 661W cells were pre-treated with TIM at different concentrations (0.1-2.5 μM) before exposure to LTA. The oxidative stress and inflammatory response were detected in 661W cells...
November 24, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29157004/vanadium-inhalation-induces-retinal-m%C3%A3-ller-glial-cell-mgc-alterations-in-a-murine-model
#7
Silvana Cervantes-Yépez, Lorena Sofía López-Zepeda, Teresa Fortoul
BACKGROUND: Vanadium (V) is a transition metal adhered to suspended particles. Previous studies demonstrated that V inhalation causes oxidative stress in the ependymal epithelium, the choroid plexus on brain lateral ventricles and in the retina. Inhaled-V reaches the eye´s retina through the systemic circulation; however, its effect on the retina has not been widely studied. The Müller glial cell provides support and structure to the retina, facilitates synapses and regulates the microenvironment and neuronal metabolism...
November 20, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28632093/allergic-contact-dermatitis-from-ophthalmics
#8
Yue Zheng, Paru R Chaudhari, Howard I Maibach
In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity.
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28468509/effect-of-trospium-chloride-therapy-on-intraocular-pressure-and-tear-secretion-in-overactive-bladder-patients
#9
Ali Riza Turkoglu, Neslihan Parmak Yener, Soner Coban, Muhammet Guzelsoy, Ali Emul, Murat Demirbas, Hakan Demirci
PURPOSE: To investigate the effect of trospium chloride, which has an anticholinergic effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment. MATERIALS AND METHODS: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28423957/trends-in-culprit-drugs-and-clinical-entities-in-cutaneous-adverse-drug-reactions-a-retrospective-study
#10
Fang Wang, Yu-Kun Zhao, Minyi Li, Zhe Zhu, Xingqi Zhang
PURPOSE: Morbidity due to cutaneous adverse drug reactions (CADRs) is quite common. The specific culprit drugs change over time and clinicians must be kept informed with updated knowledge, thus preventing potential CADRs. This retrospective study is a survey of CADRs encountered in a hospital-based population in Southern China during three time intervals, from 1984 to 2015. MATERIALS AND METHODS: The clinical records were review of 306 patients with CADRs who were admitted to our hospital from 2011 to 2015...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnosic
#11
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28397526/dynamic-thiol-disulfide-homeostasis-and-effects-of-smoking-on-homeostasis-parameters-in-patients-with-psoriasis
#12
Selma Emre, Duriye Deniz Demirseren, Murat Alisik, Akin Aktas, Salim Neselioglu, Ozcan Erel
PURPOSE: Recently, increased reactive oxygen species (ROS), reduced antioxidant capacity, and oxidative stress have been suggested in the pathogenesis of psoriasis. The aim of this study to evaluate the thiol/disulfide homeostasis in patients with psoriasis. MATERIALS AND METHODS: Ninety patients with psoriasis who did not receive any systemic treatment in the last six  months were included in the study. Seventy-six age and gender-matched healthy volunteers served as control group...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#13
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children having attention deficit hyperactivity disorder (ADHD) administered with methylphenidate hydrochloride. METHODS: Fifty-seven consecutive patients diagnosed of ADHD and administered with oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) having demographic features similar to group 1 were involved as a control group...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376651/evaluation-of-the-effects-on-choroidal-thickness-of-bimatoprost-0-03-versus-a-brinzolamide-1-0-timolol-maleate-0-5-fixed-combination
#14
Nurettin Akyol, Ahmet Kalkisim, Adem Turk, Mehmet Kola, Halil Ibrahim Imamoglu
OBJECTIVE: To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG). METHODS: Sixty-seven eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA) and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28366009/nickel-sensitivity-in-patients-with-gastroesophageal-reflux-disease
#15
Nurşad Aslan, Mesut Sezikli, Emel Erdal
OBJECTIVE: Various foods play important role in the pathogenesis of gastroesophageal reflux disease (GERD). These foods are shown to increase gastroesophageal reflux symptoms via various mechanisms and majority of these foods also contain nickel. The purpose of this study is to evaluate the relationship between Nickel sensitivity and GERD. MATERIAL AND METHODS: Fifty-four patients diagnosed with GERD and 50 healthy volunteers who were admitted to our gastroenterology outpatient clinic were took part in the study...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351170/effect-of-topiramate-on-choroidal-thickness-and-anterior-chamber-parameters-in-the-treatment-of-patients-with-migraine
#16
Mustafa Gok, Ozdemir Ozdemir
OBJECTIVE: To investigate the effects of topiramate on choroidal thickness and anterior chamber parameters using optical coherence tomography in the treatment of patients with migraine. METHODS: A total of 22 eyes of 22 adults (12 females, 10 males) diagnosed with migraine and scheduled to topiramate treatment for pain control were recruited in this prospective study. Choroidal thickness (CT), anterior chamber depth (ACD), anterior chamber angle (ACA), spherical refractive equivalent (SphEq) and intraocular pressure (IOP) measurements were recorded at baseline (prior the topiramate therapy), first and second month visits for the statistical analysis...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351163/crp-relevance-in-clinical-assessment-of-chronic-spontaneous-urticaria-tunisian-patients
#17
A Maouia, M Youssef, N Leban, J Ben Chibani, A N Helal, A Kassab
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least six weeks. Multifactorial origin is suggested such as oxidative stress. This latter may play a double role as a trigger and remnant agent. OBJECTIVES: The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: desloratadine 5 mg/d on these different parameters...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28279080/effectiveness-of-heparin-eye-drops-in-paraquat-induced-ocular-injury
#18
Liu Jian-Wei, Li Xiu-Yun, Deng Ai-Jun
PURPOSE: To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS: In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between October 2008 and October 2013. The patients were split into two groups according to whether or not received heparin eye drops. The clinical data were compared between the two groups, i...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277879/crude-4-methylcyclohexanemethanol-mchm-did-not-cause-skin-irritation-in-humans-in-48-h-patch-test
#19
Andrew D Monnot, Rachel M Novick, Dennis J Paustenbach
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background...
December 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277878/effect-of-smoking-on-the-thickness-of-retinal-layers-in-healthy-smokers
#20
Rahmi Duman, Reşat Duman, Mehmet Cem Sabaner, Ersan Çetinkaya
PURPOSE: To compare the thicknesses of the retinal layers in smokers with those of nonsmoking healthy subjects using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred and eight subjects were included in the study. Two groups were separated as smokers and nonsmokers. Both groups were chosen to be similar in terms of age and gender. SD-OCT images were generated with Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). An automated algorithm was developed to segment the macular retina into eight layers and quantitate the thickness of each layer for the fovea, parafovea and perifovea...
December 2017: Cutaneous and Ocular Toxicology
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