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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/28944688/treatment-of-lichen-planopilaris-methotrexate-or-cyclosporine-a-therapy
#1
Emel Bulbul Baskan, Serkan Yazici
BACKGROUND: Because of irreversible outcome of the lichen planopilaris(LPP), systemic therapy should be used in early inflammatory stages of the disease, without allowing the irreversible scar formation and permanent hair loss. OBJECTIVE: We assessed the efficacy and safety of methotrexate(MTX) and cyclosporine A (CsA) in the management of recalcitrant, extensive LPP and compared their efficacy and safety profile. METHODS: We retrospectively analyzed the 16 LPP cases treated with either CsA or MTX therapy...
September 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28875716/correction-to-zhu-et%C3%A2-al-common-and-uncommon-adverse-cutaneous-reactions-to-erlotinib-a-study-of-20-chinese-patients-with-cancer
#2
(no author information available yet)
No abstract text is available yet for this article.
September 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28874077/effects-of-sunitinib-and-bevacizumab-on-vegf-and-mirna-levels-on-corneal-neovascularization
#3
Harun Cakmak, Esra Gokmen, Gokay Bozkurt, Tolga Kocaturk, Kemal Ergin
AIM: To evaluate the effects of sunitinib (0.5mg/ml) and bevacizumab (5mg/ml) on VEGF-A, VEGFR-2 and microRNA (miRNA) levels on corneal neovascularization. METHODS: In this study, corneal neovascularization was induced by silver nitrate application to the cornea, and 40 Albino male rats were equally divided into 4 subgroups: Group 1 (Sunitinib): After silver nitrate application to the cornea, 0.5mg/ml sunitinib eyedrop was administered twice daily for two weeks...
September 5, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28853336/the-percutaneous-absorption-of-soman-in-a-damaged-skin-porcine-model-and-the-evaluation-of-woundstat%C3%A2-as-a-topical-decontaminant
#4
Christopher Dalton, Charlotte Hall, Helen Lydon, John Jenner, J Kevin Chipman, John S Graham, Robert P Chilcott
PURPOSE: The aim of this study was to evaluate a candidate haemostat (WoundStat™), down-selected from previous in vitro studies, for efficacy as a potential skin decontaminant against the chemical warfare agent pinacoyl methylfluorophosphonate (Soman, GD) using an in vivo pig model. MATERIALS AND METHODS: An area of approximately 3 cm(2) was dermatomed from the dorsal ear skin to a nominal depth of 100 µm. A discrete droplet of (14)C-GD (300 µg kg(-1)) was applied directly onto the surface of the damaged skin at the centre of the dosing site...
August 30, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28849680/evaluation-of-the-effect-of-erythropoietin-corticosteroid-versus-corticosteroid-alone-in-methanol-induced-optic-nerve-neuropathy
#5
Nasim Zamani, Hossein Hassanian-Moghaddam, Maziar Shojaei, Sara Rahimian
PURPOSE: Following methanol intoxication, optic nerve neuropathy may occur which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO in improvement of the visual disturbances in methanol-intoxicated patients. MATERIALS AND METHODS: In a case-control study, all patients who had referred to our toxicology center with confirmed diagnosis of methanol toxicity were considered to be included...
August 29, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28840749/evaluation-of-the-quality-of-life-in-patients-with-arsenic-keratosis
#6
Nazli Dizen Namdar, Inci Arikan, Cuneyt Kahraman, Emek Kocaturk, Merve Dagci, Ezgi Ece
BACKGROUND: Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards. OBJECTIVE: To determine the needs of patients with arsenic keratosis by evaluating the impact of disease on the quality of life with respect to treatment and provide rehabilitation services...
August 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28838263/evaluation-of-oxidative-stress-via-protein-expression-of-glutathion-s-transferase-and-cytochrome-p450-cyp450-isoenzymes-in-psoriasis-vulgaris-patients-treated-with-methotrexate
#7
Ozge Akbulak, Ayse Serap Karadag, Necmettin Akdeniz, Seyma Ozkanli, Emin Ozlu, Ebru Zemheri, Serpil Oguztuzun
INTRODUCTION: Oxidative stress is the imbalance between oxidant-antioxidant systems and may play a major role in the psoriasis pathogenesis. Cytochrome (CYP) is a family of enzymes which are responsible for the metabolism of various endogenous and exogenous substances such as drug metabolism. Most importantly, the antioxidant system is the Glutathione- S transferases (GST) which decrease oxidative stress by reducing oxidative products. AIM: We aimed to evaluate the expressions of isoenzymes of GST and CYP families and the beneficial role of metotrexate (MTX) in this process...
August 24, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28743199/3-4-methylenedioxymethamphetamine-causes-cytotoxicity-on-661w-cells-through-inducing-macrophage-polarization
#8
Xin Liu, Li-Hui Zhan, Xiao-Hong Sun, Tao Zhang, Zhi-Li Liu, Xiao-Fang Liang, Fei Zhao, Fang Liu, Guang Zeng, Chun-Sheng Luan
The abuse of 3,4-methylenedioxymethamphetamine (MDMA), a psychedelic drug, can lead to a variety of disorders in neural system, including the death of retinal neural cells. MDMA at lower doses does not cause obvious cytotoxicity to photoreceptor cells, indicating potential indirect mechanisms which have not yet been elucidated. This study investigated the effect of MDMA at nontoxic concentration on macrophage activation state and its resultant toxicity to photoreceptor cells. Using a co-culture system, cytotoxicity was caused by MDMA on 661W cells after co-culturing with RAW264...
August 16, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28743196/evaluation-of-sequential-effect-of-isotretinoin-on-the-haematological-parameters-in-patients-with-acne-vulgaris
#9
Gulsum Gencoglan, Isil Inanir, Mine Miskioglu, Kamer Gunduz
PURPOSE: Isotretinoin is the most effective drug for acne with some side effects. Few studies exist regarding the effects of isotretinoin on haematological parameters with different results. Mostly, baseline values with a single value during or at the end of the treatment were compared. In this study, we aimed to determine the differences in haematological parameters during isotretinoin treatment until reaching the cumulative dose of 120 mg/kg. MATERIALS AND METHODS: The study included 118 patients with moderate-to-severe acne vulgaris...
August 9, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28789573/the-protective-effect-of-fish-oil-against-cisplatin-induced-eye-damage-in-rat
#10
Burcu Gul Baykalir, Osman Ciftci, Aslı Cetin, Nese Basak Turkmen
Ocular toxicity induced by anticancer chemotherapy is not uncommon, but underestimated and under-reported. Visual changes have been attributed to a number of chemotherapeutic agents in humans. Cisplatin (CP), a heavy metal compound, is used in the treatment of many types of tumors. CP is known to produce non-specific blurred vision, papilledema and optic neuritis for high doses as well as cumulative dose regimens. The aim of this study was to investigate the possible beneficial effects of fish oil (FO) on eye tissue oxidative status and histological alterations against CP-induced in the rats...
August 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28737434/defining-the-timing-of-25-oh-d-rescue-following-nitrogen-mustard-exposure
#11
Lopa M Das, Amy M Binko, Zachary P Traylor, Lori Duesler, Kurt Q Lu
OBJECTIVE: Mass exposure to alkylating agents such as nitrogen mustard (NM), whether accidental or intentional as during warfare, are known to cause systemic toxicity and severe blistering from cutaneous exposure. Thus, establishing the timing and appropriate dose of any potential drug designed to reverse or impede these toxicities is critical for wound repair and survival. Our previous data demonstrates that a single intraperitoneal injection of low-dose 25-hydroxyvitamin D3 (25(OH)D) given as early as 1 h following NM exposure is sufficient to rescue mice from pancytopenia and death...
August 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28724312/in-vitro-skin-decontamination-of-paraoxon-wet-type-cleansing-effect-of-selected-detergents
#12
Ruzena Pavlikova, Jan Misik, Jiri Cabal, Jan Marek, Kamil Kuca
The aim of this study was to determine optimal conditions for in vitro skin decontamination using water and detergents as decontamination agents and to test the cleansing efficiency of selected detergents. Experiments were performed using a peristaltic pump for showering of pig skin in modified static diffusion cells. Several conditions were tested including different flow rates (from 5 to 33 ml s(-1)), quantity of rinsing fluid (from 40 to 400 ml) and concentration of detergents (2; 5; 10%). Further, several types of detergents/commercial decontamination agents were evaluated under the selected conditions to find the most effective means of decontamination...
August 7, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707485/common-and-uncommon-adverse-cutaneous-reactions-to-erlotinib-a-study-of-20-chinese-patients-with-cancer
#13
Huiling Zhu, Zhe Zhu, Weining Huang, Xiping Cheng, Jiaxi He, Chunping Xiong, Jiande Han
OBJECTIVE: This study presented common lesions with systemic toxicities and uncommon adverse cutaneous reactions such as anaphylactic dermatitis in patients undergoing treatment with erlotinib for the benefit of practicing dermatologists and oncologists. METHODS: Adverse cutaneous reactions associated with erlotinib were reported in 20 Chinese patients with cancer. RESULTS: Adverse cutaneous reactions reported included six cases of anaphylactic dermatitis, 12 cases of acneiform rash, nine cases of xerosis, five cases of nail changes and four cases of hair changes...
August 7, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707481/protective-effects-of-melatonin-and-memantine-in-human-retinal-pigment-epithelium-arpe-19-cells-against-2-ethylpyridine-induced-oxidative-stress-implications-for-age-related-macular-degeneration
#14
Handan Bardak, Abdülhadi Cihangir Uğuz, Yavuz Bardak
PURPOSE: To investigate the possible protective effects of melatonin and memantine (MMT) against 2-ethylpyridine (2-EP)-induced oxidative stress and mitochondrial dysfunction in human RPE (ARPE-19) cells in vitro. MATERIALS AND METHODS: The ARPE-19 cells were divided into seven groups. Oxidative stress was triggered by incubating the ARPE-19 cells with 30 μM of 2-EP for 24 h. Then, 200 μM of melatonin was administered over three days and 20 μM of MMT over six hours prior to the experiment...
August 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28768445/single-walled-carbon-nanotube-multi-walled-carbon-nanotube-and-fe2o3-nanoparticles-induced-mitochondria-mediated-apoptosis-in-melanoma-cells
#15
Parvaneh Naserzadeh, Fatemeh Ansari Esfeh, Mahboubeh Kaviani, Khadigeh Ashtari, Raheleh Kheirbakhsh, Ahmad Salimi, Jalal Pourahmad
PURPOSE: Nanomaterials (NM) exhibit novel anticancer properties. MATERIALS AND METHODS: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. RESULTS: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling and cytochrome c release...
August 2, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707522/the-effect-of-endothelin-receptor-antagonists-in-the-endotoxin-induced-uveitis-rabbit-model
#16
Emine Esra Karaca, Feyzahan Uzun, Ergin Dileköz, Gökçe Sevim Öztürk Fincan, Sevim Ercan, Oğuz Kul, Emin Ümit Bağrıaçık, Meral Or
PURPOSE: To investigate the effect of Bosentan (non-selective endothelin receptor antagonist) and BQ123 (ETA receptor antagonist) on intraocular inflammation in an endotoxin-induced uveitis (EIU) rabbit model METHODS: Uveitis was induced by intravitreal injection of lipopolysaccharide (LPS). The animals were divided into 7 groups and there were 6 rabbits in each group (saline, saline and ethanol, Bosentan, BQ123, Lipopolysaccharide(LPS), Bosentan and LPS, BQ123 and LPS injected groups)...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707489/evaluation-of-microrna-responses-in-arpe-19-cells-against-the-oxidative-stress
#17
Lokman Ayaz, Erdem Dinç
PURPOSE: This study aimed to determine microRNA (miRNA) expression profile of human retinal pigment epithelium cell (ARPE-19) against the oxidative stress induced by hydrogen peroxide (H2O2). METHODS: ARPE-19 cells were incubated with different concentrations of H2O2 (200, 600 and 800 µM) for 18 hours, and then cell viability, vascular endothelial growth factor levels and total oxidant status were evaluated. Expressions of 1152 miRNA were determined by quantitative Real-Time PCR in each group...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28697703/retrospective-analysis-of-the-effect-of-aflibercept-loading-dose-on-the-retinal-vessel-diameters-in-patients-with-treatment-naive-neovascular-amd
#18
Mehmet Tetikoğlu, Muhammed Mustafa Kurt, Hacı Murat Sağdık, Serdar Aktaş, Medine Aslı Yıldırım, Fatih Özcura
BACKGROUND: To evaluate the effects of intravitreal aflibercept (IVA) on retinal vessel diameters in patients with neovascular age-related macular degeneration (AMD). DESIGN, SETTING, AND PARTICIPANTS: A retrospective study conducted at the Kutahya Dumlupinar University Faculty of Medicine included fifteen eyes of fifteen patients with treatment naive neovascular AMD. METHODS: All eyes received IVA injections once per month for 3 months; untreated contralateral eyes were used as controls...
July 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28693384/eye-irritation-potential-palm-based-methyl-ester-sulphonates
#19
Nor Zuliana Yusof, Zafarizal Aldrin Azizul Hasan, Zulina Abd Maurad, Zainab Idris
Eye irritation tests are widely used to assess the ocular irritancy of chemicals. Measurement of eye irritancy is necessary for safety evaluation of both industrial and consumer products. The eye irritancy assessment of palm-based methyl ester sulphonates (MES) of different chain lengths; C12, C14, C16, C16:18 were evaluated using Top-Down approach strategy as suggested by European Centre for the Validation of Alternative Methods. The Bovine Corneal Opacity and Permeability test method (BCOP), OECD Test Guideline 437, was used as an initial step to study the inducing effect of palm-based MES on irreversible eye damage...
July 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27917684/the-long-term-effect-of-oral-isotretinoin-therapy-on-macula-ganglion-cell-complex-thickness
#20
Gülizar Demirok, Yasemin Topalak, Özge Gündüz, Dilsun Yildirim, Mehmet Fatih Kocamaz, Ahmet Şengün
PURPOSE: To evaluate the long-term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included in this study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment...
September 2017: Cutaneous and Ocular Toxicology
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