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Cutaneous and Ocular Toxicology

Fatih Baltu, Ahmet Murat Sarici, Onur Yildirim, Burak Mergen, Erkut Bolat
PURPOSE: This study aims to evaluate the association between age-related macular degeneration (AMD) and cardiovascular disease by using the noninvasive flow-mediated dilation (FMD) test to show endothelial dysfunction as an indicator of subclinical atherosclerosis. METHOD: Participants in this study included 30 dry AMD patients, 30 wet AMD patients, and 30 healthy controls without any systemic disease, including AMD. FMD and the intima media thickness (IMT) of the carotid artery were compared between the groups...
September 11, 2018: Cutaneous and Ocular Toxicology
Umit Eksioglu, Hasan Ikbal Atilgan, Mehmet Yakin, Nuray Yazihan, Ugur Emrah Altiparmak, Nihat Yumusak, Meliha Korkmaz, Ayten Demir, Firdevs Ornek, Pelin Aribal Ayral, Gokhan Koca
PURPOSE: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland. MATERIALS AND METHODS: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medication. The second group was appointed as the positive control group that only received 3 mCi/kg (111 MBq/kg) RAI via gastric gavage and the last group was the treatment group that received 3 mCi/kg RAI via same method and calcitriol (200 ng/kg/day) via intraperitoneal administration...
September 11, 2018: Cutaneous and Ocular Toxicology
Amar Pujari, Aswini Behera, Ritika Mukhija, Rohan Chawla, Suresh Yadav, Namrata Sharma
PURPOSE: To correlate the anatomical extent of ocular surface toxicity due to colours using anterior segment optical coherence tomography (ASOCT) with the clinical findings. METHODS: Patients presenting to our emergency department with ocular colour toxicity during the Holi festival celebrations from March 2 2018 to March 5 2018 were assessed for any adnexal, conjunctival, corneal, and anterior chamber findings, as well as findings on anterior segment optical coherence tomography...
September 10, 2018: Cutaneous and Ocular Toxicology
Asghar Beigi Harchegani, Abolfazl Khor, Eisa Tahmasbpour, Mahdi Ghatrehsamani, Hamid Bakhtiari Kaboutaraki, Alireza Shahriary
Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appears to be involved in SM-induced injuries. SM may trigger several molecular and cellular pathways linked to OS and inflammation that can subsequently result in cell death and apoptosis...
September 10, 2018: Cutaneous and Ocular Toxicology
Erel Icel, Turgay Uçak, Burcu Agcayazi, Yücel Karakurt, Hayati Yilmaz, Ferda Keskin Çimen, Halis Süleyman
AIM: To determine the effects of Pycnogenol on cisplatin-induced optic nerve damage. MATERIAL AND METHOD: Totally 18 albino Wistar male rats were assigned into three groups, with six rats in each group as follows: healthy controls (HC group), only cisplatin (2.5 mg/kg) administered group (CIS group) and Pycnogenol (40 mg/kg) + cisplatin (2.5 mg/kg) administered group (PYC group). We analyzed the levels of malondialdehyde (MDA) as a marker of lipid peroxidation and oxidative stress, total glutathione (tGSH) as a marker of antioxidant status, nuclear factor-kappa B (NF-κB) and tumor necrosis factor alpha (TNF-α) as inflammatory markers, total oxidative status (TOS) and total antioxidant status (TAS) on eye tissue together with histopathological evaluation of optic nerve in an experimental model...
September 10, 2018: Cutaneous and Ocular Toxicology
Ersoy Acer, Hilal Kaya Erdogan, Nihan Yüksel Çanakçı, Zeynep Nurhan Saracoglu
PURPOSE: The mechanism of action of omalizumab in chronic spontaneous urticaria (CSU) is not exactly known. In previous studies, d-dimer which is a fibrin-degradation product and interleukin-31 which has a role in inflammation were found to be decreased in patients with chronic urticaria treated with omalizumab. However, to our knowledge, there is no study on the effects of omalizumab on the ratio of neutrophil to lymphocyte (NLR) and the ratio of platelet to lymphocyte (PLR) which are inflammatory parameters in patients with CSU in the PubMed database...
September 10, 2018: Cutaneous and Ocular Toxicology
Hüseyin Fındık, Levent Tumkaya, Adnan Yılmaz, Mehmet Gökhan Aslan, Murat Okutucu, Kerimali Akyildizi, Tolga Mercantepe
This study investigated the toxic effects of an antineoplastic agent, Cisplatin (CIS), on retinal cells and the potential capacity of Astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal toxicity. Six groups were formed for the assessment; control (healthy; Group 1), olive oil (olive oil only; Group 2), ASTA control group (ASTA only, Group 3), the single intraperitoneal (IP) dose of 16 mg/kg CIS (CIS only group; Group 4), 16 mg/kg CIS + 25 mg/kg (IP) ASTA (Group 5) and 16 mg/kg CIS + 75 mg/kg (IP) ASTA (Group 6)...
September 5, 2018: Cutaneous and Ocular Toxicology
Yue Zheng, Songchao Yin, Yue Xia, Jian Chen, Congxiu Ye, Quanrong Zeng, Wei Lai
BACKGROUND: Topical drugs for mild to moderate acne include adapalene(ADA) and benzoyl peroxide(BPO). Supramolecular salicylic acid (SSA), a modified SA preparation, is considered as a new effective therapeutic schemes. OBJECTIVES: To compare the safety and efficacy of 2% supramolecular SA (2%SSA) with 0.01% adapalene plus 5% benzoyl peroxide (5%BPO+0.1%ADA)for treatment of facial acne. MATERIALS AND METHODS: This was an open-label, split face, randomized and single center clinical trial ...
September 3, 2018: Cutaneous and Ocular Toxicology
Sertac Sener, Ayse Akbas, Fadime Kılınc, Pervin Baran, Ozcan Erel, Akin Aktas
BACKGROUND: Rosacea is the chronic inflammatory disease of the facial skin. Although its etiology is not clear yet, inflammatory processes triggered by oxidative stress and oxidation of lipids have been suggested to have a role. While studies on the relationship between inflammation and oxidative stress are ongoing, thiol metabolism and its role in oxidative stress have also begun to be investigated. Thiols are among the key molecules of protein metabolism in the organism and they are firstly consumed antioxidants in case of oxidative stress...
September 3, 2018: Cutaneous and Ocular Toxicology
Ernest S Fung, Rachel M Novick, Derek A Drechsel, Kevin M Towle, Dennis J Paustenbach, Andrew D Monnot
The U.S. Food and Drug Administration (FDA) does not require specific testing to demonstrate the safety of personal care and cosmetic products or their ingredients. Recently, there have been reports of skin irritation associated with the use of commercially available cleansing conditioners. The goal of this study was to implement a tier-based safety assessment approach to evaluate the skin irritation potential of six commercially available cleansing conditioners and their ingredients. The first tier of testing utilized the Organisation for Economic Co-operation and Development (OECD) QSAR Toolbox to perform an in silico evaluation of the skin irritation potential of the product ingredients, and the second tier of testing utilized an OECD in vitro test to evaluate the skin irritation potential of each product...
August 19, 2018: Cutaneous and Ocular Toxicology
Yan-Yan Wang, Chen-Guang Wang, Shou-Nan Qi, Zao-Xia Liu, Guan-Fang Su, Ya-Juan Zheng
Retinitis pigmentosa (RP) caused by the photoreceptor cell degeneration is currently incurable and leads to partial or complete blindness eventually. 3,5-dimethoxy-4-hydroxy myricanol (DM) is a novel compound isolated from the leaves of Micromelum integerrimum, with proliferative activities on NIH3T3 cells. This study was to investigate whether DM could mitigate retinal degeneration of rd10 mice, a well-characterized mouse model of RP. Rd10 mice were treated with DM daily by intraperitoneal injection from postnatal day 12 (P12) to P26...
August 6, 2018: Cutaneous and Ocular Toxicology
Hidehisa Sekijima, Kenji Goto, Keiichi Hiramoto, Rio Komori, Kazuya Ooi
PURPOSE: Type 2 diabetes mellitus (DM) induces various dermatological conditions that can affect patient quality of life, including increased susceptibility to skin infections and dry skin. While the mechanisms that underlie the causes of dry skin in type 1 DM have been widely studied, how type 2 DM elicits similar effects is unclear. The purpose of this study was therefore to evaluate skin barrier and hydration function using a KK-Ay /TaJcl mouse model of type 2 DM. MATERIALS AND METHODS: KK-Ay /TaJcl and control mice were housed separately for 4 weeks and then body weight, water intake, urine production, and blood glucose levels were measured...
July 31, 2018: Cutaneous and Ocular Toxicology
Jessica C Graham, Nathan Wilt, Gertrude-Emilia Costin, Caren Villano, Jackie Bader, Lindsay Krawiec, Elizabeth Sly, Janet Gould
INTRODUCTION: Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on eye and skin can now be assessed using validated in vitro methods. OBJECTIVES: Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular and dermal irritation/corrosion potential of PCs to inform worker safety within the pharmaceutical space...
July 23, 2018: Cutaneous and Ocular Toxicology
Yücel Karakurt, Turgay Uçak, NurdanGamze Tasli, Ibrahim Ahiskali, Sare Şipal, Nezahat Kurt, Halis Süleyman
AIM: Lutein is one of the most common carotenoids defined in human plasma as having potent anti-oxidant effects. We aimed to determine the biochemical and histopathological effects of lutein on cisplatin-induced oxidative retinal injury in rats. MATERIALS AND METHODS: Twenty-four rats were equally divided into four groups as healthy controls (HC group), only cisplatin (5 mg/kg) administered group (CIS group), Lutein (0.5 mg/kg) + cisplatin (5 mg/kg) administered group (LC group), and only Lutein (0...
July 23, 2018: Cutaneous and Ocular Toxicology
Cahit Yavuz, Muammer Ozcimen
Oral isotretinoin (13-cis retinoic acid, 13-cis RA) was approved for severe acne treatment by the FDA in 1982. It is still one of the most preferred drugs in dermatology practice from that date till now. There are numerous side effects of oral isotretinoin therapy. The ocular side effects associated with oral isotretinoin use are mostly dose-dependent. Numerous ocular pathologies affect peripapillary choroidal layer primarily or indirectly. Evaluation of the peripapillary choroidal layer in the patients receiving oral isotretinoin therapy may aid in explaining the pathophysiology of ocular side effects...
July 22, 2018: Cutaneous and Ocular Toxicology
Hande Güçlü, Zeynep Banu Doganlar, Vuslat Pelitli Gürlü, Altan Özal, Ayten Dogan, Meryem Aysenur Turhan, Oguzhan Doganlar
AIM: Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer including anal, gastrointestinal, and oral cancer, as well as head and neck tumors. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain unclear. The aim of this study is to explain the possible mechanisms by which combined PF treatment results in retinal toxicity and to investigate the effects of PF on important vital signalling pathways in ARPE 19 retinal pigmented epithelial cells...
September 2018: Cutaneous and Ocular Toxicology
Fehim Esen, Azer Erdagi Bulut, Ebru Toker
PURPOSE: The aim of this study was to evaluate the efficacy and safety of topical atropine and topical atropine combined with intracameral low-concentration, bisulphite-containing epinephrine treatment for the prophylaxis of intraoperative floppy iris syndrome. MATERIALS AND METHODS: Seventy-two eyes of 55 male patients who were treated with alpha-adrenergic antagonist medications for benign prostatic hyperplasia were included in this study. Standard premedication with topical cyclopentolate, phenylephrine, tropicamide and ketorolac was applied to all of the patients...
September 2018: Cutaneous and Ocular Toxicology
Ozlem Onerci Celebi, Ali Riza Cenk Celebi
PURPOSE: The effect of ocular artificial teardrop containing benzalkonium chloride (BAC) on nasal mucosa was investigated. MATERIALS AND METHODS: There were two different treatment trial groups. Each dry eye syndrome (DES) patient received the ocular lubricant treatment four times a day in both groups (one group containing BAC, the other group was not). Moistened sterile cotton-tipped applicators were placed in both nostrils and were immediately cultured prior to ocular lubricant treatment and at the end of treatment trial...
September 2018: Cutaneous and Ocular Toxicology
Reşat Duman, Ayhan Vurmaz
PURPOSE: The exact etiopathogenesis of steroid-induced cataracts (SIC) is not known. Although oxidative stress is one of the most acceptable hypotheses, the exact molecular events in steroid-induced oxidative events in the lens need to be clarified. In addition, to the best of our knowledge, the innate immune system components in SIC formation have not been studied previously. The aim of the present study was to study the oxidative system and the innate immune system components in the cataractous lenses of a developing chick embryo SIC model...
September 2018: Cutaneous and Ocular Toxicology
Lihua Zhu, Jia Li, Dayang Wu, Bing Li
PURPOSE: To investigate the protective effect of beta-casomorphin-7 (β-CM-7) in oxidative stressed human lens epithelial cells (HLECs) and to explore the possible mechanism for oxidative stress in HLECs induced by high glucose. METHODS: We used HLECs to determine the effect of different concentrations of β-CM-7 on cell viability by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolimol/L bromide (MTT) assay. We used flow cytometry to determine the content of reactive oxygen species (ROS) induced by oxidative stress and a bioassay kit to determine the oxidant malondialdehyde (MDA) and antioxidant enzyme superoxide dismutase (SOD) levels...
September 2018: Cutaneous and Ocular Toxicology
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