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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/27927024/investigation-of-thiol-disulphide-balance-in-patients-with-acute-urticaria-and-chronic-spontaneous-urticaria
#1
Ayse Akbas, Fadime Kilinc, Sertac Sener, Akın Aktaş, Pervin Baran, Merve Ergin
BACKGROUND: Thiol-disulphide balance plays a major role in health and diseases. This balance may be disrupted by various diseases. We aimed to determine status of the effect of thiol-disulphide balance in urticaria. OBJECTIVES: We aimed to investigate the thiol-disulphide balance in patients with acute urticaria (AUP) and chronic spontaneous urticaria (CSU). METHODS: Study included 53 AUP and 47 healthy controls plus 57 patients with chronic spontaneous urticaria (CSUP) and 57 healthy controls...
January 18, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28095713/disseminated-eruptive-granuloma-annulare-induced-by-levetiracetam
#2
Betul Sereflican, Tekden Karapinar, Selma Erdogan Duzcu, Şule Aydin Turkoglu
Granuloma annulare (GA) is a benign, granulomatous cutaneous disease without clear etiology. Disseminated and drug induced granuloma annulare is a rare presentation. We present a 47-year-old woman with diffuse circular erythematous eruptions following treatment with levetiracetam. Her clinical and histopathological findings were compatible with the diagnosis of granuloma annulare. To the best of our knowledge, there is no previous report of this skin disease as a result of levetiracetam use. We report this case to highlight this antiepileptic drug as a possible etiologic agent in disseminated granuloma annulare...
January 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27486965/the-safety-and-efficacy-of-diphoterine-for-ocular-and-cutaneous-burns-in-humans
#3
Darren D Lynn, Leonid M Zukin, Robert Dellavalle
CONTEXT: Diphoterine, developed by the French company Prevor, is a polyvalent, chelating, amphoteric and slightly hypertonic solution used in the management of chemical cutaneous and ocular burns. While used extensively in Europe and Canada, it is has not been approved by the United States Occupational Safety and Health Administration (OSHA) as an alternative to the water-rinse method due to a lack of evidence of its safety and efficacy on human subjects. An unbiased and extensive systematic review was undertaken in order to better understand Diphoterine's safety and efficaciousness on humans...
January 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28076996/a-serious-case-of-anthrax-associated-with-compartment-syndrome
#4
Seyran Kılınç, Mehmet Vakıf Keskinbıçkı, Murat Şengül, Semra Nergiz, Abdurrahman Örtücü, Okay Bulut
Compartment syndrome linked to skin anthrax is a rare complication that may develop and it should be noted that the disease may progress in spite of medical drug treatment. Our case was a farmer who was exposed after slaughtering a dead animal, a time delay for treatment hided this history and then developed compartment syndrome. In anthrax cases with delayed treatment and aggressive progression, circulation in the extremities should be carefully noted. We believe that the cases with compartment syndrome progressing in spite of medical drug treatment may be assessed for fasciotomy as a treatment approach...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28076993/evaluation-of-clinical-and-serological-findings-for-diagnosis-of-cutaneous-anthrax-infection-after-an-outbreak
#5
Duygu Gulseren, Serap Süzük-Yıldız, Bekir Çelebi, Selçuk Kılıç
PURPOSE: Anthrax, caused by the bacterium Bacillus anthracis, is one of the oldest documented infectious diseases in both livestock and humans.We aimed to evaluate clinical findings and risk factors of patients with cutaneous anthrax infection and report anti-lethal factor (LF) IgG and anti-protective antigene (PA) IgG titers in the serologic diagnosis of disease. METHODS: In this study, serum samples of 18 cutaneous anthrax patients were collected and anti-LF IgG and anti-PA IgG titers were measured by enzyme-linked immunosorbent assay (ELISA)...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28073339/dermal-safety-assessment-of-arm-hammer-laundry-products-formulated-for-sensitive-skin
#6
Douglas M Frederick, Linda Vorwerk, Archana Gupta, Annahita Ghassemi
CONTEXT: The prevalence of sensitive skin among the general population in industrialized countries is reported to be over 50%. Sensitive skin subjects often report significant reactions to contact with cosmetics, soaps and other consumer products. OBJECTIVE: This paper describes the overall skin compatibility and mildness program for a newly developed, lightly fragranced, colorant free laundry product (i.e. Arm & Hammer™ Sensitive Skin plus Skin-Friendly Fresh Scent), specially formulated for individuals with sensitive skin...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067074/dynamic-thiol-disulphide-homeostasis-in-patients-with-basal-cell-carcinoma
#7
Duriye Deniz Demirseren, Cagla Cicek, Murat Alisik, Mustafa Erol Demirseren, Akın Aktaş, Ozcan Erel
BACKGROUND: The aim of this study is to measure and compare the dynamic thiol/disulphide homeostasis of patients with basal cell carcinoma and healthy subjects with a newly developed and original method. OBJECTIVE: Thirty four patients attending our outpatient clinic and clinically and histopathologically diagnosed as nodular basal cell carcinoma, and age and gender match 30 healthy individuals have been involved in the study. Thiol/disulphide homeostasis tests have been measured with a novel automatic spectrophotometric method developed and the results have been compared statistically...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067070/warfarin-affects-acute-inflammatory-response-induced-by-subcutaneous-polyvinyl-sponge-implantation-in-rats
#8
Ivana Mirkov, Aleksandra Popov, Jelena Demenesku, Marina Ninkov, Dina Mileusnic, Dragan Kataranovski, Milena Kataranovski
PURPOSE: Warfarin (WF) is anticoagulant which also affects physiological processes other than hemostasis. Our previous investigations showed the effect of WF which gained access to the organism via skin on resting peripheral blood granulocytes. Based on these data, the aim of the present study was to examine whether WF could modulate the inflammatory processes as well. To this aim the effect of warfarin on the inflammatory response induced by subcutaneous sponge implantation in rats was examined...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067065/the-investigation-of-antimicrobial-peptides-expression-and-its-related-interaction-with-methotrexate-treatment-in-patients-with-psoriasis-vulgaris
#9
Emin Ozlu, Ayse Serap Karadag, Seyma Ozkanli, Serpil Oguztuzun, Ozge Akbulak, Tugba Kevser Uzuncakmak, Serkan Demirkan, Necmettin Akdeniz
BACKGROUND: Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls. METHODS: Immunohistochemical expressions of hBD-1 and hBD-2 were assessed in 16 patients with psoriasis vulgaris and 20 normal skin biopsies from healthy controls...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27903082/itraconazole-induced-thrombocytopenia
#10
Berna Aksoy
Itraconazole is one of the systemic treatment options for extensive tinea versicolor. A male patient who developed thrombocytopenia during the treatment of tinea versicolor by itraconazole is reported in this manuscript. He was diagnosed to develop thrombocytopenia on the third day of treatment. In the literature, there are two reports of itraconazole-induced thrombocytopenia both in malignancy patients. One report contained three patients who developed thrombocytopenia as a result of a drug interaction between bortezomib and itraconazole...
December 21, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27892714/-2r-3s-pinobanksin-3-cinnamate-ameliorates-photoreceptor-degeneration-in-pde6-rd-10-mice
#11
Yin Li, Tuo Li, Jia-Zhang Li, Qing-Song Wu
As an inherited disorder caused by initial death of rod photoreceptors, retinitis pigmentosa is currently untreatable and usually leads to partial or complete blindness. (2R, 3S)-Pinobanksin-3-cinnamate (PC) is a new flavonone isolated from the seed of Alpinia galanga Willd, and has been reported to exert neuroprotective effects by upregulating endogenous antioxidant enzymes. In this study, the anti-oxidative and neuroprotective activity of PC against photoreceptor apoptosis in rd10 mouse model of retinitis pigmentosa was explored...
December 21, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27825281/modulation-of-chemical-dermal-absorption-by-14-natural-products-a-quantitative-structure-permeation-analysis-of-components-often-found-in-topical-preparations
#12
Faqir Muhammad, Majid Jaberi-Douraki, Damião Pergentino de Sousa, Jim E Riviere
A large number of cosmetics and topical pharmaceuticals contain compounds of natural origin. There is a rising concern if these compounds can interact with the activity of other topically applied components in these formulations. The current study demonstrates modulation of dermal absorption of model components often found in topical preparations ((14)C caffeine and (14)C salicylic acid) by a set of 14 compounds of natural origin using a flow through in vitro porcine skin diffusion system. The parameters of flux and permeability were calculated and quantitative structure permeation relationship (QSPR) analysis conducted on different molecular descriptors of modulator compounds...
December 14, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27838929/change-in-flash-visual-evoked-potentials-in-new-zealand-albino-rabbits-after-sub-tenon-s-anesthesia
#13
Xiaofei Wu, Vishal Jhanji, Haoyu Chen, Hongjie Lin, Guihua Zhang, Marten Brelen, Weiqi Chen
CONTEXT: The occurrence of amaurosis during ophthalmic anesthesia is well known. The reason for this manifestation has not been studied. PURPOSE: To investigate the effect of sub-tenon's anesthesia on visual conduction in rabbit eyes. METHODS: Fifteen right eyes of 15 New Zealand albino rabbits were included. 2% lidocaine hydrochloride and 0.75% bupivacaine hydrochloride (1 ml, 1:1 mixture) was injected in the sub-tenon's space of 8 eyes while the control group (n = 7) was injected with 1 ml physiological saline...
December 13, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27917684/the-long-term-effect-of-oral-isotretinoin-therapy-on-macula-ganglion-cell-complex-thickness
#14
Gülizar Demirok, Yasemin Topalak, Özge Gündüz, Dilsun Yıldırım, Mehmet Fatih Kocamaz, Ahmet Sengun
PURPOSE: To evaluate the long term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included to study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment...
December 4, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27903086/the-association-of-smokeless-tobacco-use-and-pack-years-of-smokeless-tobacco-with-age-related-macular-degeneration-in-indian-population
#15
Sangeetha Srinvasan, Gayathri Swaminathan, Vaitheeswaran Kulothungan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore the association of use and the influence of pack-year use of smokeless tobacco versus no use with that of early and late age-related macular degeneration (AMD) in rural and urban south Indian population. We hypothesized that the use and pack-years of use would be significantly associated with both early and late AMD. We therefore sought to examine subjects who gave a history of using smokeless tobacco and we quantified the usage as pack-years, to examine the association with that of early and late AMD...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27903073/comparison-between-early-or-late-intravitreal-injection-of-dexamethasone-implant-in-branch-brvo-or-central-crvo-retinal-vein-occlusion-six-months-follow-up
#16
Fernanda Pacella, Giuseppe La Torre, Stefania Basili, Monica Autolitano, Antonella Pascarella, Tommaso Lenzi, Elena Pacella
PURPOSE: The purpose of this study was to compare early and late injections of intravitreal dexamethasone implant in patients affected by central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) with a six-month follow-up. We assessed whether an earlier treatment start (within 7 days from diagnosis) could be more beneficial than a delayed (or late) treatment start (after 7 days). MATERIALS AND METHODS: The study included 81 patients (81 eyes) affected by retinal vein occlusion...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27881029/pemphigus-herpetiformis-type-drug-reaction-caused-by-erdosteine-containing-mucolytic-in-a-child
#17
Gulsen Akoglu, Sibel Orhun Yavuz
Drug-related pemphigus is very rare in children. Erdosteine is a thiol compound having mucoactive, antioxidant, anti-inflammatory, and antitussive effects and is reported to be safe for treatment of acute respiratory tract diseases in children. Herein, we report a 9-year-old boy presented with pemphigus herpetiformis associated with anti-desmoglein 1 antibodies due to erdosteine consumption.
November 23, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27802779/assessment-of-demodex-presence-in-acne-like-rash-associated-with-cetuximab
#18
Deniz Aksu Arıca, Turkan Ozturk Topcu, Leyla Baykal Selçuk, Savas Yaylı, Unzile Seyman, Evren Fidan, Sevgi Bahadır, Halil Kavgacı
CONTEXT: Cetuximab is an epidermal growth factor receptor inhibitor. It is frequently used in the treatment of solid tumors. However, it has a high potential to cause acne-like rash. Demodex mites, which are known to increase in number in immunosuppressive circumstances, are closely related to the acneiform lesions. OBJECTIVE: The aim of this study is to evaluate the presence of demodex mites in acne-like rash that appears under the treatment of Cetuximab. METHODS: We reviewed the medical records of patients who applied to our clinic with cetuximab induced papulopustular rashes between November 2014 and March 2016...
November 16, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27764978/the-prevalence-of-sacroiliitis-in-patients-with-acne-vulgaris-using-isotretinoin
#19
Leyla Baykal Selçuk, Deniz Aksu Arıca, Hanife Baykal Şahin, Savas Yaylı, Sevgi Bahadır
BACKGROUND/OBJECTIVE: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit in the skin. Isotretinoin is a synthetic vitamin A derivative regarded as the most effective agent in the treatment of acne. There have recently been increasing reports of adverse effects of isotretinoin on the skeletal system. Our aim in this study was to evaluate the rheumatic side-effects triggered by this drug, and particularly the prevalence of sacroiliitis. MATERIALS AND METHODS: A total of 73 patients receiving isotretinoin due to moderate or severe acne vulgaris were included...
November 16, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27825268/variation-in-skin-biology-to-climate-in-shanghai-china
#20
Xiaoping Liu, Yanrui Gao, Yiyi Zhang, Xuemin Wang
PURPOSE: To explore the relationship between climate and skin condition, investigate the variation of skin biology to climatic change. METHODS: 2005 healthy Chinese volunteers living in Shanghai (aged 13 to 69 years) were recruited. Transepidermal water loss and stratum corneum hydration were tested on six sites (forehead, cheek, nasolabial, inner forearm, dorsal hand and palm) by non-invasive devices between January 2005 and December 2012. The corresponding climate data was recorded by local Weather Bureau...
November 8, 2016: Cutaneous and Ocular Toxicology
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