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Cutaneous and Ocular Toxicology

Gülizar Demirok, Yasemin Topalak, Özge Gündüz, Dilsun Yıldırım, Mehmet Fatih Kocamaz, Ahmet Sengun
PURPOSE: To evaluate the long term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included to study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment...
December 4, 2016: Cutaneous and Ocular Toxicology
Sangeetha Srinvasan, Gayathri Swaminathan, Vaitheeswaran Kulothungan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore the association of use and the influence of pack-year use of smokeless tobacco versus no use with that of early and late age-related macular degeneration (AMD) in rural and urban south Indian population. We hypothesized that the use and pack-years of use would be significantly associated with both early and late AMD. We therefore sought to examine subjects who gave a history of using smokeless tobacco and we quantified the usage as pack-years, to examine the association with that of early and late AMD...
November 30, 2016: Cutaneous and Ocular Toxicology
Berna Aksoy
Itraconazole is one of the systemic treatment options for extensive tinea versicolor. A male patient who developed thrombocytopenia during the treatment of tinea versicolor by itraconazole is reported in this manuscript. He was diagnosed to develop thrombocytopenia on the third day of treatment. In the literature, there are two reports of itraconazole induced thrombocytopenia both in malignancy patients. One report contained three patients who developed thrombocytopenia as a result of a drug interaction between bortezomib and itraconazole...
November 30, 2016: Cutaneous and Ocular Toxicology
Fernanda Pacella, Giuseppe La Torre, Stefania Basili, Monica Autolitano, Antonella Pascarella, Tommaso Lenzi, Elena Pacella
PURPOSE: The purpose of this study was to compare early and late injections of intravitreal dexamethasone implant in patients affected by central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) with a six-month follow-up. We assessed whether an earlier treatment start (within 7 days from diagnosis) could be more beneficial than a delayed (or late) treatment start (after 7 days). MATERIALS AND METHODS: The study included 81 patients (81 eyes) affected by retinal vein occlusion...
November 30, 2016: Cutaneous and Ocular Toxicology
Yin Li, Tuo Li, Yi-Qiao Xing, Jia-Zhang Li, Qing-Song Wu
As an inherited disorder caused by initial death of rod photoreceptors, retinitis pigmentosa is currently untreatable and usually leads to partial or complete blindness. (2R, 3S)-pinobanksin-3-cinnamate (PC) is a new flavonone isolated from the seed of Alpinia galanga Willd, and has been reported to exert neuroprotective effects by upregulating endogenous antioxidant enzymes. In this study, the anti-oxidative and neuroprotective activity of PC against photoreceptor apoptosis in rd10 mouse model of retinitis pigmentosa was explored...
November 28, 2016: Cutaneous and Ocular Toxicology
Gulsen Akoglu, Sibel Orhun Yavuz
Drug-related pemphigus is very rare in children. Erdosteine is a thiol compound having mucoactive, antioxidant, anti-inflammatory, and antitussive effects and is reported to be safe for treatment of acute respiratory tract diseases in children. Herein, we report a 9-year-old boy presented with pemphigus herpetiformis associated with anti-desmoglein 1 antibodies due to erdosteine consumption.
November 23, 2016: Cutaneous and Ocular Toxicology
Deniz Aksu Arıca, Turkan Ozturk Topcu, Leyla Baykal Selçuk, Savas Yaylı, Unzile Seyman, Evren Fidan, Sevgi Bahadır, Halil Kavgacı
CONTEXT: Cetuximab is an epidermal growth factor receptor inhibitor. It is frequently used in the treatment of solid tumors. However, it has a high potential to cause acne-like rash. Demodex mites, which are known to increase in number in immunosuppressive circumstances, are closely related to the acneiform lesions. OBJECTIVE: The aim of this study is to evaluate the presence of demodex mites in acne-like rash that appears under the treatment of Cetuximab. METHODS: We reviewed the medical records of patients who applied to our clinic with cetuximab induced papulopustular rashes between November 2014 and March 2016...
November 16, 2016: Cutaneous and Ocular Toxicology
Leyla Baykal Selçuk, Deniz Aksu Arıca, Hanife Baykal Şahin, Savas Yaylı, Sevgi Bahadır
BACKGROUND/OBJECTIVE: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit in the skin. Isotretinoin is a synthetic vitamin A derivative regarded as the most effective agent in the treatment of acne. There have recently been increasing reports of adverse effects of isotretinoin on the skeletal system. Our aim in this study was to evaluate the rheumatic side-effects triggered by this drug, and particularly the prevalence of sacroiliitis. MATERIALS AND METHODS: A total of 73 patients receiving isotretinoin due to moderate or severe acne vulgaris were included...
November 16, 2016: Cutaneous and Ocular Toxicology
Xiao-Fei Wu, Vishal Jhanji, Haoyu Chen, Hong-Jie Lin, Gui-Hua Zhang, Marten Brelen, W Q Chen
CONTEXT: The occurrence of amaurosis during ophthalmic anesthesia is well known. The reason for this manifestation has not been studied. PURPOSE: To investigate the effect of sub-tenon's anesthesia on visual conduction in rabbit eyes. METHODS: Fifteen right eyes of 15 New Zealand albino rabbits were included. 2% lidocaine hydrochloride and 0.75% bupivacaine hydrochloride (1 ml, 1:1 mixture) was injected in the sub-tenon's space of 8 eyes while the control group (n = 7) was injected with 1ml physiological saline...
November 13, 2016: Cutaneous and Ocular Toxicology
Faqir Muhammad, Majid Jaberi-Douraki, Damião Pergentino de Sousa, Jim E Riviere
A large number of cosmetics and topical pharmaceuticals contain compounds of natural origin. There is a rising concern if these compounds can interact with the activity of other topically applied components in these formulations. The current study demonstrates modulation of dermal absorption of model components often found in topical preparations ((14)C caffeine and (14)C salicylic acid) by a set of 14 synthetic compounds of natural origin using a flow through in-vitro porcine skin diffusion system. The parameters of flux and permeability were calculated and quantitative structure permeation (QSPR) analysis conducted on different molecular descriptors of modulator compounds...
November 8, 2016: Cutaneous and Ocular Toxicology
Xiaoping Liu, Yanrui Gao, Yiyi Zhang, Xuemin Wang
PURPOSE: To explore the relationship between climate and skin condition, investigate the variation of skin biology to climatic change. METHODS: 2005 healthy Chinese volunteers living in Shanghai (aged 13 to 69 years) were recruited. Transepidermal water loss and stratum corneum hydration were tested on six sites (forehead, cheek, nasolabial, inner forearm, dorsal hand and palm) by non-invasive devices between January 2005 and December 2012. The corresponding climate data was recorded by local Weather Bureau...
November 8, 2016: Cutaneous and Ocular Toxicology
Hazem Matar, Joanne Larner, Vanessa Viegas, Sneha Kansagra, Karen L Atkinson, Satyajit Shetage, John T Skamarauskas, Baveetharan Theivendran, Virginia S Goldman, Robert P Chilcott
CONTEXT: Incontinence-associated dermatitis (IAD) is a type of moisture-associated dermatitis caused by repeated skin exposure to urine or stool. A product that could mitigate such symptoms would have a significant impact on cost of care and patients' quality of life. OBJECTIVE: This study compared the clinical efficacy of RD1433 and a comparator product (Vaseline®) in preventing and treating experimental IAD skin lesions. MATERIALS AND METHODS: For the "prevention" part of the study, skin sites in eight human volunteers were treated daily for five days with either RD1433 or Vaseline® immediately prior to synthetic urine exposure...
November 6, 2016: Cutaneous and Ocular Toxicology
Nélia Cunha, Pedro Cardoso, Joana Cabete
Although radiation dermatitis is a widely known complication of radiotherapy, its association with fluoroscopy-guided interventional procedures is yet underrecognized. We present a case of a 66-year-old man with a left scapular cutaneous lesion, initially diagnosed as a fixed drug eruption. The subsequent knowledge of a previous percutaneous aortic paravalvular leak closure procedure allowed a correct clinicopathological correlation and the final diagnosis of subacute radiodermatitis associated with fluoroscopy...
November 6, 2016: Cutaneous and Ocular Toxicology
Selma Emre, Hilal Ahsen, Akın Aktaş
BACKGROUND: Fixed drug eruption is a special variant of drug reaction which is seen on skin or mucous membrane and typically recurs at the same location. Ornidazole-induced fixed drug eruption cases have been reported extremely rare. CASE: The 48-years old female patient was diagnosed as ornidazole-induced fixed drug reaction on the sole. The patient's history revealed that the lesion occurred for the third time in the last 6 months and she was administered ornidazole tablet by the gynecologist for 3 times due to genitourinary tract infection in the last 6 months...
October 26, 2016: Cutaneous and Ocular Toxicology
Gonce Elcin, Duygu Gülseren, Miyase Bayraktar, Serdar Gunalp, Timur Gurgan
Autoimmune estrogen dermatitis is a cyclical cutaneous eruption that occurs premenstrually and rapid resolution of the eruptions within a few days of menstrual cycles. The disorder has variable clinical manifestations consisting of macules, papules, vesicles, urticarial lesions, bullae, eczematous plaques, and erythema multiforme-like lesions. Herein, we present a case of a 30-year-old woman with attacks of edema and erosions involving the oral and genital mucosal sites on every first day of her menstruation period...
October 11, 2016: Cutaneous and Ocular Toxicology
Ayse Dolar Bilge, Fariz Sadigov, Senem Salar-Gomceli
BACKGROUND: Botulinum toxin A (BTX) has been widely used for a variety of facial esthetic procedures within the last couple of decades. Efficacy and safety of BTX for facial rejuvenation has been extensively studied in multiple randomized prospective controlled trials. Focal weakness is among the most commonly reported adverse effects. Adverse reactions tend to occur most commonly due to errors in dosing formulation and errors with the techniques of the application. No serious long-term complications have been reported...
September 26, 2016: Cutaneous and Ocular Toxicology
Fadime Kilinc, Ayse Akbas, Sertac Sener, Akın Aktaş
BACKGROUND: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Up to now, not many atypical forms are reported. OBJECTIVE: To determine the clinical characteristics of patients with atypical pityriasis rosea. METHODS: A total of 27 cases, diagnosed as atypical PR by clinical and/or histopathological examination and applied to the outpatient clinic of dermatology department between the years 2007 and 2015 were analyzed retrospectively...
September 26, 2016: Cutaneous and Ocular Toxicology
Neera Tewari-Singh, Claire R Croutch, Richard Tuttle, Dinesh G Goswami, Rama Kant, Eric Peters, Tara Culley, David A Ammar, Robert W Enzenauer, J Mark Petrash, Robert P Casillas, Rajesh Agarwal
Ocular injury by lewisite (LEW), a potential chemical warfare and terrorist agent, results in edema of eyelids, inflammation, massive corneal necrosis and blindness. To enable screening of effective therapeutics to treat ocular injury from LEW, useful clinically-relevant endpoints are essential. Hence, we designed an efficient exposure system capable of exposing up to six New-Zealand white rabbits at one time, and assessed LEW vapor-induced progression of clinical ocular lesions mainly in the cornea. The right eye of each rabbit was exposed to LEW (0...
December 2016: Cutaneous and Ocular Toxicology
Aysun Sanal Dogan, Evrim Onder, Ata Turker Arikok, Tolga Bicer, Canan Gurdal
CONTEXT: Pterygium is the fibrovascular growth of the limbal conjunctiva over cornea. This proliferative nature might have a pathogenesis associated with tight junction proteins. OBJECTIVE: To investigate the tight junction protein claudin-1 expressions in pterygium with respect to normal conjunctiva. MATERIALS AND METHODS: This retrospective study included 28 patients who underwent pterygium surgery with autograft. Claudin-1 expressions were immunohistochemically evaluated in normal and lesional conjunctiva of the same eye...
December 2016: Cutaneous and Ocular Toxicology
Sung Uk Baek, In Won Park, Wool Suh
PURPOSE: To assess the long-term intraocular pressure (IOP) changes after the intravitreal injection of bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for treatment of age-related macular degeneration (AMD) and diabetic macular edema (DME) patients and evaluate the correlation factors. MATERIAL AND METHODS: Patients with neovascular AMD or DME underwent treat-and-extended anti-VEGF regimen in one eye and followed more than 12 months were enrolled in this study...
December 2016: Cutaneous and Ocular Toxicology
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