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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/28277879/crude-4-methylcyclohexanemethanol-mchm-did-not-cause-skin-irritation-in-humans-in-48-h-patch-test
#1
Andrew D Monnot, Rachel M Novick, Dennis J Paustenbach
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background...
March 13, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28279080/effectiveness-of-heparin-eye-drops-in-paraquat-induced-ocular-injury
#2
Liu Jian-Wei, Li Xiu-Yun, Deng Ai-Jun
PURPOSE: To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS: In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between October 2008 and October 2013. The patients were split into two groups according to whether or not received heparin eye drops. The clinical data were compared between the two groups, i...
March 9, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277877/results-of-intravitreal-ranibizumab-treatment-for-retinopathy-of-prematurity-in-infants
#3
Emine Alyamaç Sukgen, Yusuf Koçluk
PURPOSE: To assess the results of intravitreal ranibizumab treatment for retinopathy of prematurity (ROP) in infants. METHODS: A single-institution, retrospective consecutive case series. RESULTS: Thirty-one patients who received ranibizumab treatment for ROP were evaluated in this study. The mean follow-up time was 14 ± 1.37 months. Vascularization of the peripheral retina had completed with delay in the majority of cases and also avascular areas were present in the peripheral retinas of five infants at one year of age...
March 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277878/effect-of-smoking-on-the-thickness-of-retinal-layers-in-healthy-smokers
#4
Rahmi Duman, Reşat Duman, Mehmet Cem Sabaner, Ersan Çetinkaya
PURPOSE: To compare the thicknesses of the retinal layers in smokers with those of non smoking healthy subjects using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred and eight subjects were included in the study. Two groups were separated as smokers and non-smokers. Both groups were chosen to be similar in terms of age and gender. SD-OCT images were generated with Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). An automated algorithm was developed to segment the macular retina into eight layers and quantitate the thickness of each layer for the fovea, parafovea and perifovea...
March 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28166658/sodium-perbarate-and-benzalkonium-chloride-induce-dna-damage-in-chang-conjunctival-epithelial-cells
#5
Huina Zhang, Han Wu, Jun Yang, Juan Ye
Content and objective: To investigate and compare the toxic effects of benzalkonium chloride (BAC) and new type oxidative preservative sodium perborate (NaBO3) on DNA damage, reactive oxygen species (ROS), and cell survival in immortalized human Chang conjunctival cells. MATERIAL AND METHODS: Cells were exposed to BAC and NaBO3 in concentrations of 0.00001% to 0.001% for 30 min. Cell viability was measured by the MTT test. Alkaline comet assay was used to detect DNA damage. Mitochondrial membrane potential (MMP), cell apoptosis, and reactive oxygen species production were detected by flow cytometry analysis...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28166657/ocular-surface-effects-of-repeated-application-of-povidone-iodine-in-patients-receiving-frequent-intravitreal-injections
#6
Habiba Saedon, Jennifer Nosek, Julian Phillips, Nirodhini Narendran, Yit C Yang
BACKGROUND: The aim of this study was to investigate the patient reported symptoms and objective signs of tear film and ocular surface abnormalities experienced by patients undergoing repeated exposure to povidone iodine as a consequence of requiring frequent intravitreal injections for wet macular degeneration. METHODS: This was a prospective study of consecutive patients who had received recent povidone 5% solution for sterile preparation of intravitreal injection less than 3 months prior to inclusion with a total of at least 3 intravitreal injections for macular degeneration...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067074/dynamic-thiol-disulphide-homeostasis-in-patients-with-basal-cell-carcinoma
#7
Duriye Deniz Demirseren, Cagla Cicek, Murat Alisik, Mustafa Erol Demirseren, Akın Aktaş, Ozcan Erel
BACKGROUND: The aim of this study is to measure and compare the dynamic thiol/disulphide homeostasis of patients with basal cell carcinoma and healthy subjects with a newly developed and original method. OBJECTIVE: Thirty four patients attending our outpatient clinic and clinically and histopathologically diagnosed as nodular basal cell carcinoma, and age and gender matched 30 healthy individuals have been involved in the study. Thiol/disulphide homeostasis tests have been measured with a novel automatic spectrophotometric method developed and the results have been compared statistically...
February 1, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28122465/clinical-profile-and-triggering-factors-for-acquired-bilateral-nevus-of-ota-like-macules
#8
Qi Zhang, Cheng Tan, Pei Jiang, Gang Yang
BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. METHODS A survey was carried out using the clinical examination and a questionnaire on 3,212 first-time outpatients in our dermatology department, and 102 cases of ABNOM were subsequently enrolled...
January 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27927024/investigation-of-thiol-disulphide-balance-in-patients-with-acute-urticaria-and-chronic-spontaneous-urticaria
#9
Ayse Akbas, Fadime Kilinc, Sertac Sener, Akın Aktaş, Pervin Baran, Merve Ergin
BACKGROUND: Thiol-disulphide balance plays a major role in health and diseases. This balance may be disrupted by various diseases. We aimed to determine status of the effect of thiol-disulphide balance in urticaria. OBJECTIVES: We aimed to investigate the thiol-disulphide balance in patients with acute urticaria (AUP) and chronic spontaneous urticaria (CSU). METHODS: Study included 53 AUP and 47 healthy controls plus 57 patients with chronic spontaneous urticaria (CSUP) and 57 healthy controls...
January 18, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28095713/disseminated-eruptive-granuloma-annulare-induced-by-levetiracetam
#10
Betul Sereflican, Tekden Karapinar, Selma Erdogan Duzcu, Şule Aydin Turkoglu
Granuloma annulare (GA) is a benign, granulomatous cutaneous disease without clear etiology. Disseminated and drug induced granuloma annulare is a rare presentation. We present a 47-year-old woman with diffuse circular erythematous eruptions following treatment with levetiracetam. Her clinical and histopathological findings were compatible with the diagnosis of granuloma annulare. To the best of our knowledge, there is no previous report of this skin disease as a result of levetiracetam use. We report this case to highlight this antiepileptic drug as a possible etiologic agent in disseminated granuloma annulare...
January 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27486965/the-safety-and-efficacy-of-diphoterine-for-ocular-and-cutaneous-burns-in-humans
#11
Darren D Lynn, Leonid M Zukin, Robert Dellavalle
CONTEXT: Diphoterine, developed by the French company Prevor, is a polyvalent, chelating, amphoteric and slightly hypertonic solution used in the management of chemical cutaneous and ocular burns. While used extensively in Europe and Canada, it is has not been approved by the United States Occupational Safety and Health Administration (OSHA) as an alternative to the water-rinse method due to a lack of evidence of its safety and efficacy on human subjects. An unbiased and extensive systematic review was undertaken in order to better understand Diphoterine's safety and efficaciousness on humans...
January 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28076996/a-serious-case-of-anthrax-associated-with-compartment-syndrome
#12
Seyran Kılınç, Mehmet Vakıf Keskinbıçkı, Murat Şengül, Semra Nergiz, Abdurrahman Örtücü, Okay Bulut
Compartment syndrome linked to skin anthrax is a rare complication that may develop and it should be noted that the disease may progress in spite of medical drug treatment. Our case was a farmer who was exposed after slaughtering a dead animal, a time delay for treatment hided this history and then developed compartment syndrome. In anthrax cases with delayed treatment and aggressive progression, circulation in the extremities should be carefully noted. We believe that the cases with compartment syndrome progressing in spite of medical drug treatment may be assessed for fasciotomy as a treatment approach...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28076993/evaluation-of-clinical-and-serological-findings-for-diagnosis-of-cutaneous-anthrax-infection-after-an-outbreak
#13
Duygu Gulseren, Serap Süzük-Yıldız, Bekir Çelebi, Selçuk Kılıç
PURPOSE: Anthrax, caused by the bacterium Bacillus anthracis, is one of the oldest documented infectious diseases in both livestock and humans.We aimed to evaluate clinical findings and risk factors of patients with cutaneous anthrax infection and report anti-lethal factor (LF) IgG and anti-protective antigene (PA) IgG titers in the serologic diagnosis of disease. METHODS: In this study, serum samples of 18 cutaneous anthrax patients were collected and anti-LF IgG and anti-PA IgG titers were measured by enzyme-linked immunosorbent assay (ELISA)...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28073339/dermal-safety-assessment-of-arm-hammer-laundry-products-formulated-for-sensitive-skin
#14
Douglas M Frederick, Linda Vorwerk, Archana Gupta, Annahita Ghassemi
CONTEXT: The prevalence of sensitive skin among the general population in industrialized countries is reported to be over 50%. Sensitive skin subjects often report significant reactions to contact with cosmetics, soaps and other consumer products. OBJECTIVE: This paper describes the overall skin compatibility and mildness program for a newly developed, lightly fragranced, colorant free laundry product (i.e. Arm & Hammer™ Sensitive Skin plus Skin-Friendly Fresh Scent), specially formulated for individuals with sensitive skin...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067070/warfarin-affects-acute-inflammatory-response-induced-by-subcutaneous-polyvinyl-sponge-implantation-in-rats
#15
Ivana Mirkov, Aleksandra Popov, Jelena Demenesku, Marina Ninkov, Dina Mileusnic, Dragan Kataranovski, Milena Kataranovski
PURPOSE: Warfarin (WF) is anticoagulant which also affects physiological processes other than hemostasis. Our previous investigations showed the effect of WF which gained access to the organism via skin on resting peripheral blood granulocytes. Based on these data, the aim of the present study was to examine whether WF could modulate the inflammatory processes as well. To this aim the effect of warfarin on the inflammatory response induced by subcutaneous sponge implantation in rats was examined...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067065/the-investigation-of-antimicrobial-peptides-expression-and-its-related-interaction-with-methotrexate-treatment-in-patients-with-psoriasis-vulgaris
#16
Emin Ozlu, Ayse Serap Karadag, Seyma Ozkanli, Serpil Oguztuzun, Ozge Akbulak, Tugba Kevser Uzuncakmak, Serkan Demirkan, Necmettin Akdeniz
BACKGROUND: Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls. METHODS: Immunohistochemical expressions of hBD-1 and hBD-2 were assessed in 16 patients with psoriasis vulgaris and 20 normal skin biopsies from healthy controls...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27160965/the-safety-of-isotretinoin-in-patients-with-lupus-nephritis-a-comprehensive-review
#17
REVIEW
Bartosz Miziołek, Beata Bergler-Czop, Anna Stańkowska, Ligia Brzezińska-Wcisło
Oral isotretinoin (13-cis-retinoinc acid) is a derivative of vitamin A and belongs to the first generation of retinoids, which act as synthetic isomers of retinoic acid (RA). It is a very effective agent in a treatment of acne vulgaris; however, multiple side effects related to therapy with retinoids preclude the use of isotretinoin in less severe acne vulgaris. A significant limitation for the administration of isotretinoin appears in case of concomitant kidney disease with a special attention regarding the safety of the agent in patients with lupus nephritis (LN)...
March 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27160797/delayed-progression-of-diabetic-cataractogenesis-and-retinopathy-by-litchi-chinensis-in-stz-induced-diabetic-rats
#18
Eswar Kumar Kilari, Swathi Putta
CONTEXT: The study was carried out to evaluate the effect of the aqueous fruit pericarp extract of Litchi chinensis (APLC) on parameters which leads to diabetic cataractogenesis and retinopathy in the streptozotocin-induced diabetic rats. OBJECTIVE: The objective of the study is to evaluate the APLC for in vivo antioxidant activity and its role in inhibiting the polyol pathway and formation of advanced glycation end products (AGEs). MATERIALS AND METHODS: The diabetic animals were treated with L...
March 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27079364/toxic-epidermal-necrolysis-13-years-of-experience-in-the-management-at-a-department-of-dermatology-in-china
#19
Feng Zhang, Jin Zhou
OBJECTIVE: The study aimed to investigate the efficacy of our therapeutic options on toxic epidermal necrolysis (TEN) patients. METHODS: After giving informed consent, patients affected by TEN were included in the study between January 2001 and December 2013. Suspected causative drugs, onset to hospitalization, complications, management, outcome, laboratory investigations of blood tests and therapeutic options were recorded and analyzed. SCORTEN scoring system was used to evaluate the complications and the survival rate...
March 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27055483/biosafety-of-an-entomopathogenic-fungus-isaria-fumosorosea-in-an-acute-dermal-test-in-rabbits
#20
Carolina Brunner-Mendoza, Hortensia Navarro-Barranco, Benjamín León-Mancilla, Armando Pérez-Torres, Conchita Toriello
Isaria fumosorosea (formerly Paecilomyces fumosoroseus) is an entomopathogenic fungus that has been proposed as a low risk environmental alternative to the use of chemical insecticides to control agricultural pests and disease vectors. Although there are some mycoinsecticides already being marketed in many countries, not all their biosafety protocols have been published. The acute dermal toxicity test in an animal model is one in a series of biosafety protocols that must be developed, in order to provide information on health hazards, while taking into consideration the periods that the workers are in direct contact with the microbial agent when applied for the control of pests...
March 2017: Cutaneous and Ocular Toxicology
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