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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/28707522/the-effect-of-endothelin-receptor-antagonists-in-the-endotoxin-induced-uveitis-rabbit-model
#1
Emine Esra Karaca, Feyzahan Uzun, Ergin Dileköz, Gökçe Sevim Öztürk Fincan, Sevim Ercan, Oğuz Kul, Emin Ümit Bağrıaçık, Meral Or
PURPOSE: To investigate the effect of Bosentan (non-selective endothelin receptor antagonist) and BQ123 (ETA receptor antagonist) on intraocular inflammation in an endotoxin-induced uveitis (EIU) rabbit model METHODS: Uveitis was induced by intravitreal injection of lipopolysaccharide (LPS). The animals were divided into 7 groups and there were 6 rabbits in each group (saline, saline and ethanol, Bosentan, BQ123, Lipopolysaccharide(LPS), Bosentan and LPS, BQ123 and LPS injected groups)...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707489/evaluation-of-microrna-responses-in-arpe-19-cells-against-the-oxidative-stress
#2
Lokman Ayaz, Erdem Dinç
PURPOSE: This study aimed to determine microRNA (miRNA) expression profile of human retinal pigment epithelium cell (ARPE-19) against the oxidative stress induced by hydrogen peroxide (H2O2). METHODS: ARPE-19 cells were incubated with different concentrations of H2O2 (200, 600 and 800 µM) for 18 hours, and then cell viability, vascular endothelial growth factor levels and total oxidant status were evaluated. Expressions of 1152 miRNA were determined by quantitative Real-Time PCR in each group...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707485/common-and-uncommon-adverse-cutaneous-reactions-to-erlotinib-a-study-of-20-chinese-patients-with-cancer
#3
Huiling Zhu, Zhe Zhu, Weining Huang, Xiping Cheng, Jiaxi He, Chunping Xiong, Jiande Han
Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, is used for treating non-small cell lung cancers. It is frequently known to cause skin toxicities. Systemic toxicities and anaphylactic cutaneous reactions have been rarely mentioned. Adverse cutaneous reactions were reported in 20 patients, including 6 cases of anaphylactic dermatitis, 12 cases of acneiform rash, 9 cases of xerosis, 5 cases of nail changes, and 4 cases of hair changes. One case of anaphylactic dermatitis manifested as erythema with swelling on the face and neck, and others as erosive and scaly erythema on the fold of skin, or red macules, papules, plaques, and pigmentation on the whole body...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28707481/protective-effects-of-melatonin-and-memantine-in-human-retinal-pigment-epithelium-arpe-19-cells-against-2-ethylpyridine-induced-oxidative-stress-implications-for-age-related-macular-degeneration
#4
Handan Bardak, Abdülhadi Cihangir Uğuz, Yavuz Bardak
PURPOSE: To investigate the possible protective effects of melatonin and memantine (MMT) against 2-ethylpyridine (2-EP)-induced oxidative stress and mitochondrial dysfunction in human RPE (ARPE-19) cells in vitro. MATERIALS AND METHODS: The ARPE-19 cells were divided into seven groups. Oxidative stress was triggered by incubating the ARPE-19 cells with 30 µM of 2-EP for 24 hours. Then, 200 µM of melatonin was administered over three days and 20 µM of MMT over six hours prior to the experiment...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28697703/retrospective-analysis-of-the-effect-of-aflibercept-loading-dose-on-the-retinal-vessel-diameters-in-patients-with-treatment-naive-neovascular-amd
#5
Mehmet Tetikoğlu, Muhammed Mustafa Kurt, Hacı Murat Sağdık, Serdar Aktaş, Medine Aslı Yıldırım, Fatih Özcura
BACKGROUND: To evaluate the effects of intravitreal aflibercept (IVA) on retinal vessel diameters in patients with neovascular age-related macular degeneration (AMD). DESIGN, SETTING, AND PARTICIPANTS: A retrospective study conducted at the Kutahya Dumlupinar University Faculty of Medicine included fifteen eyes of fifteen patients with treatment naive neovascular AMD. METHODS: All eyes received IVA injections once per month for 3 months; untreated contralateral eyes were used as controls...
July 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28693384/eye-irritation-potential-palm-based-methyl-ester-sulphonates
#6
Nor Zuliana Yusof, Zafarizal Aldrin Azizul Hasan, Zulina Abd Maurad, Zainab Idris
Eye irritation tests are widely used to assess the ocular irritancy of chemicals. Measurement of eye irritancy is necessary for safety evaluation of both industrial and consumer products. The eye irritancy assessment of palm-based methyl ester sulphonates (MES) of different chain lengths; C12, C14, C16, C16:18 were evaluated using Top-Down approach strategy as suggested by European Centre for the Validation of Alternative Methods. The Bovine Corneal Opacity and Permeability test method (BCOP), OECD Test Guideline 437, was used as an initial step to study the inducing effect of palm-based MES on irreversible eye damage...
July 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28658977/n-hydroxymethylglycinate-with-edta-is-an-efficient-eye-drop-preservative-with-very-low-toxicity-an-in-vitro-comparative-study
#7
Martina Cristaldi, Melania Olivieri, Gabriella Lupo, Carmelina D Anfuso, Salvatore Pezzino, Dario Rusciano
PURPOSE: Preservatives are used in multi-dose ophthalmic topical medications in order to prevent contamination by bacteria and fungi. However, prolonged use of preserved eye drops, as it may happen in dry eye or glaucoma, may damage cells of the ocular surface. Therefore, an important goal is to find preservatives with low toxicity which are mild to host cells, still able to prevent drug contamination so to maintain their sterility and efficacy. Hence, aim of this study has been to compare the relative toxicity on a rabbit corneal cell line of a new preservative, made by the association of N-hydroxy-methyl-glycinate (NIG) with disodium-ethylene diamine tetra-acetate (EDTA), with other known and widely used eye-drops preservatives...
June 28, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28573874/role-of-mast-cells-in-the-induction-of-dry-skin-in-a-mouse-model-of-rheumatoid-arthritis
#8
Kenji Goto, Keiichi Hiramoto, Hijiri Kita, Kazuya Ooi
PURPOSE: Rheumatoid arthritis (RA) is known to induce dry skin as an extra-articular symptom. However, the mechanisms behind the induction are unclear. In this study, we utilized an arthritis mouse model to simulate RA to reveal the relationship between arthritis and dry skin. MATERIALS AND METHODS: DBA/1JJmsSlc control mice (n = 5) and DBA/1JJmsSlc collagen-induced arthritis mouse model (arthritis mice; n = 5) were used. We measured transepidermal water loss (TEWL) and capacitance to reveal the effect of arthritis on skin barrier function...
June 21, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28486855/the-effects-of-smoking-on-corneal-endothelial-cells-a-cross-sectional-study-on-a-population-from-isfahan-iran
#9
Khodayar Golabchi, Mohammad-Ali Abtahi, Ali Salehi, Hamidreza Jahanbani-Ardakani, Sara Ghaffari, Ziba Farajzadegan
PURPOSE: The aim of this study is to compare the effect of smoking in corneal endothelial cell number and morphology by specular microscopy on a non-smoker population. METHODS: Our cross-sectional study was performed on 150 participants from a non-smoker population. Non-contact specular microscopy (Tomey Corporation Inc., Nagoya, Japan) was performed in the center of the cornea of all subjects. The cell density (CD), average cell size (AVG), percent of hexagonality (HEX%) and central corneal thickness (CCT) were calculated and compared in both groups...
June 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28614955/systemic-effects-after-intravitreal-injection-of-bevacizumab-in-new-born-rabbit-eyes
#10
Yih-Shiou Hwang, Chi-Hsien Liu, Yin-Cheng Huang, Chih-Shan Chen, Tun-Lu Chen, Nan-Kai Wang, Yen-Po Chen, Kwan-Jen Chen, Chi-Chun Lai, Wei-Chi Wu
PURPOSE: To determine the systemic impact of intravitreal bevacizumab (IVB), an anti-vascular endothelium growth factor antibody, after injection into newborn rabbit eyes. MATERIALS AND METHODS: We used four groups of rabbits. Group 1 rabbits received a single injection of IVB starting from the age of 6 weeks. Group 2 rabbits received a single injection of balanced salt solution (BSS, 0.025 ml) and served as controls for group 1. Group 3 rabbits received 2 consecutive injections of IVB at the ages of 6 weeks and 10 weeks...
June 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28592159/taurine-prevents-ultraviolet-b-induced-apoptosis-in-retinal-ganglion-cells
#11
Wu Dayang, Pang Dongbo
BACKGROUND: Compatible osmolytes accumulation is an active resistance response in retina under ultraviolet radiation and hypertonicity conditions. OBJECTIVE: The purpose of this research is to investigate the protective role of taurine on retina under ultraviolet B radiation. METHODS: Osmolytes transporters was measured by quantitative realtime PCR. Osmolytes uptake was estimated by radioimmunoassay. Cell viability was caculated by MTT assay...
June 7, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28504010/effects-of-selective-serotonin-reuptake-inhibitors-on-intraocular-pressure-and-anterior-segment-parameters-in-open-angle-eyes
#12
Gamze Uçan Gündüz, Neslihan Parmak Yener, Oğuzhan Kılınçel, Cem Gündüz
PURPOSE: To evaluate the short- and long-term effects of selective serotonin reuptake inhibitors (SSRIs) on intraocular pressure (IOP) and anterior segment parameters in open angle eyes. MATERIALS AND METHODS: This cross-sectional study included 325 eyes of 166 subjects. Subjects were divided into three groups: Group 1 included 116 eyes of 58 patients receiving SSRIs for 1 week-6 months, Group 2 included 102 eyes of 53 patients receiving SSRIs for longer than 6 months and Group 3 included 107 eyes of 55 healthy subjects not receiving any drugs...
June 1, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28554225/lutein-improves-cell-viability-and-reduces-alu-rna-accumulation-in-hydrogen-peroxide-challenged-retinal-pigment-epithelial-cells
#13
You Sheng Chong, Chun Wai Mai, Chee Onn Leong, Lai Chun Wong
PURPOSE: Dysfunction of the microRNA (miRNA)-processing enzyme DICER1 and Alu RNA accumulation are linked to the pathogenesis of age-related macular degeneration (AMD). This study determined the optimal dose of lutein (LUT) and zeaxanthin (ZEA) to protect human retinal pigment epithelium (RPE) cells against hydrogen peroxide (H2O2). The effect of the optimal dose of LUT and ZEA as DICER1 and Alu RNA modulators in cultured human RPE cells challenged with H2O2 was investigated. MATERIALS AND METHODS: ARPE-19 cells were pre-treated with LUT, ZEA or both for 24 hours before 200 µM H2O2 challenge...
May 29, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28486821/oral-warfarin-affects-some-aspects-of-systemic-immunomodulation-with-topical-dinitrochlorobenzene-dncb-in-rats
#14
Aleksandra Popov Aleksandrov, Sandra Belij-Rammerstorfer, Ivana Mirkov, Vesna Subota, Jelena Kulas, Dragan Kataranovski, Milena Kataranovski
PURPOSE: The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy...
May 29, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28468507/the-reduction-in-inflammation-and-impairment-in-wound-healing-by-using-strontium-chloride-hexahydrate
#15
Sibel Berksoy Hayta, Kasim Durmuş, Emine Elif Altuntaş, Esin Yildiz, Mehmet Hisarciklıo, Melih Akyol
BACKGROUND: Numerous growth factors, cytokine, mitogen and chemotactic factors are involved in wound healing. Even though inflammation is important for the stimulation of proliferative phase, excessive inflammation also causes impairment in wound healing. Strontium salts suppress keratinocyte-induced TNF-alpha and interleukin-1 and interleukin-6 in in vitro cultures. This study was conducted to determine the effects of administration of topical strontium chloride hexahydrate on wound healing through TNF-alpha and TGF-beta in surgical wound healing model of in-vivo rat skin...
May 22, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28427301/corneal-endothelial-changes-in-long-term-cannabinoid-users
#16
Nihat Polat, Birgul Cumurcu, Tongabay Cumurcu, İlknur Tuncer
PURPOSE: The aim of this study was at evaluating the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy. METHODS: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for three days or more per week over the past one year. Thirty-two eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study...
May 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28468509/effect-of-trospium-chloride-therapy-on-intraocular-pressure-and-tear-secretion-in-overactive-bladder-patients
#17
Ali Riza Turkoglu, Neslihan Parmak Yener, Soner Coban, Muhammet Guzelsoy, Ali Emul, Murat Demirbas, Hakan Demirci
PURPOSE: To investigate the effect of trospium chloride, which has an anticholinergic effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment. MATERIALS AND METHODS: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started...
May 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28372461/decontamination-of-rat-and-human-skin-experimentally-contaminated-with-99m-tc-201-tl-and-131-i-radionuclides-using-dermadecon-a-skin-decontamination-kit-an-efficacy-study
#18
Dhruv Kumar Nishad, Supriya Bhalla, Kushagra Khanna, Braj Gaurav Sharma, Harish Singh Rawat, Gaurav Mittal, Aseem Bhatnagar
Radioactive skin contamination is one of the most likely risks which occurs after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person who is contaminated should be decontaminated as early as possible to reduce the damaging health effects of radiation. In the present study, the decontamination efficiency of a developed skin decontamination kit "dermadecon" has been evaluated in animal models and human subjects using gamma scintigraphy...
May 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnosic
#19
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
April 27, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28393562/intravitreal-anti-vegf-treatment-for-retinopathy-of-prematurity-in-infants-with-active-adenoviral-keratoconjunctivitis
#20
Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC). MATERIAL AND METHODS: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP...
April 27, 2017: Cutaneous and Ocular Toxicology
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