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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/28427301/corneal-endothelial-changes-in-long-term-cannabinoid-users
#1
Nihat Polat, Birgul Cumurcu, Tongabay Cumurcu, İlknur Tuncer
PURPOSE: The aim of this study was to evaluate the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy. METHODS: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for 3 days or more per week over the past 1 year. 32 eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study...
April 20, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28423957/trends-in-culprit-drugs-and-clinical-entities-in-cutaneous-adverse-drug-reactions-a-retrospective-study
#2
Fang Wang, Yu-Kun Zhao, Minyi Li, Zhe Zhu, Xingqi Zhang
PURPOSE: Morbidity due to cutaneous adverse drug reactions (CADRs) is quite common. The specific culprit drugs change over time and clinicians must be kept informed with updated knowledge, thus preventing potential CADRs. This retrospective study is a survey of CADRs encountered in a hospital-based population in Southern China during three time intervals, from 1984 to 2015. MATERIALS AND METHODS: The clinical records were review of 306 patients with CADRs who were admitted to our hospital from 2011 to 2015...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28359163/pityriasis-rosea-like-eruption-induced-by-isotretinoin
#3
Gülhan Gürel, Sevinç Şahin, Emine Çölgeçen
Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Isotretinoin is usually used in the treatment of resistant, nodulocytic acne. We present a case of pityriasis rosea-like eruption induced by isotretinoin. To our knowledge, this is the second clinical case of pityriasis rosea-like eruption induced by isotretinoin.
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351170/effect-of-topiramate-on-choroidal-thickness-and-anterior-chamber-parameters-in-the-treatment-of-patients-with-migraine
#4
Mustafa Gok, Ozdemir Ozdemir
OBJECTIVE: To investigate the effects of topiramate on choroidal thickness and anterior chamber parameters using optical coherence tomography in the treatment of patients with migraine. METHODS: A total of 22 eyes of 22 adults (12 females, 10 males) diagnosed with migraine and scheduled to topiramate treatment for pain control were recruited in this prospective study. Choroidal thickness (CT), anterior chamber depth (ACD), anterior chamber angle (ACA), spherical refractive equivalent (SphEq) and intraocular pressure (IOP) measurements were recorded at baseline (prior the topiramate therapy), first and second month visits for the statistical analysis...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnostic
#5
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
April 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28397526/dynamic-thiol-disulphide-homeostasis-and-effects-of-smoking-on-homeostasis-parameters-in-patients-with-psoriasis
#6
Selma Emre, Duriye Deniz Demirseren, Murat Alisik, Akin Aktas, Salim Neselioglu, Ozcan Erel
PURPOSE: Recently, increased reactive oxygen species (ROS), reduced antioxidant capacity, and oxidative stress have been suggested in the pathogenesis of psoriasis. The aim of this study to evaluate the thiol/disulphide homeostasis in patients with psoriasis. MATERIALS AND METHODS: Ninety patients with psoriasis who did not receive any systemic treatment in the last 6 months were included in the study. Seventy-six age and gender-matched healthy volunteers served as control group...
April 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28393562/intravitreal-anti-vegf-treatment-for-retinopathy-of-prematurity-in-infants-with-active-adenoviral-keratoconjunctivitis
#7
Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC). MATERIAL AND METHODS: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP...
April 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#8
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children who is taking methylphenidate hydrochloride with Attention Deficit Hyperactivity Disorder. METHODS: Fifty seven consecutive patients who were diagnosed of Attention Deficit Hyperactivity Disorder (ADHD) and have been under oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) who have similar demographic features compared with the group 1, were involved as a control group...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376651/evaluation-of-the-effects-on-choroidal-thickness-of-bimatoprost-0-03-versus-a-brinzolamide-1-0-timolol-maleate-0-5-fixed-combination
#9
Nurettin Akyol, Ahmet Kalkisim, Adem Turk, Mehmet Kola, Halil Ibrahim Imamoglu
OBJECTIVE: To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG). METHODS: 67 eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA), and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28372461/decontamination-of-rat-and-human-skin-experimentally-contaminated-with-99mtc-201tl-131i-radionuclides-using-dermadecon-a-skin-decontamination-kit-an-efficacy-study
#10
Dhruv Kumar Nishad, Supriya Bhalla, Kushagra Khanna, Braj Gaurav Sharma, Harish Singh Rawat, Mittal Gaurav, Aseem Bhatnagar
Radioactive skin contamination is one of the most likely risks after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person contaminated should be decontaminated as soon as possible to reduce the damaging health effects of radiation. In present study, the decontamination efficiency of a developed skin decontamination kit 'Dermadecon' has been evaluated in animal models and human subjects using gamma scintigraphy...
April 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28366009/nickel-sensitivity-in-patients-with-gastroesophageal-reflux-disease
#11
Nurşad Aslan, Mesut Sezikli, Emel Erdal
OBJECTIVE: Various foods play important role in the pathogenesis of gastroesophageal reflux disease (GERD). These foods are shown to increase gastroesophageal reflux symptoms via various mechanisms and majority of these foods also contain nickel. The purpose of this study is to evaluate the relationship between Nickel sensitivity and GERD. MATERIAL AND METHODS: Fifty four patients diagnosed with GERD and 50 healthy volunteers who were admitted to our gastroenterology outpatient clinic were took part in the study...
April 2, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351163/crp-relevance-in-clinical-assessment-of-chronic-spontaneous-urticaria-tunisian-patients
#12
Amal Maouia, Monia Youssef, Nadia Leban, Ahmed Noureddine Helal, Asma Kassab
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least 6 weeks. Multifactorial origin is suggested such as Oxidative stress. This latter may play a double role as a trigger and remnant agent. OBJECTIVES: The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: Desloratadine 5mg/day on these different parameters...
March 28, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277877/results-of-intravitreal-ranibizumab-treatment-for-retinopathy-of-prematurity-in-infants
#13
Emine Alyamaç Sukgen, Yusuf Koçluk
PURPOSE: To assess the results of intravitreal ranibizumab treatment for retinopathy of prematurity (ROP) in infants. METHODS: A single-institution, retrospective consecutive case series. RESULTS: Thirty-one patients who received ranibizumab treatment for ROP were evaluated in this study. The mean follow-up time was 14 ± 1.37 months. Vascularization of the peripheral retina had completed with delay in the majority of cases and also avascular areas were present in the peripheral retinas of five infants at one year of age...
March 27, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277879/crude-4-methylcyclohexanemethanol-mchm-did-not-cause-skin-irritation-in-humans-in-48-h-patch-test
#14
Andrew D Monnot, Rachel M Novick, Dennis J Paustenbach
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background...
March 13, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28279080/effectiveness-of-heparin-eye-drops-in-paraquat-induced-ocular-injury
#15
Liu Jian-Wei, Li Xiu-Yun, Deng Ai-Jun
PURPOSE: To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS: In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between October 2008 and October 2013. The patients were split into two groups according to whether or not received heparin eye drops. The clinical data were compared between the two groups, i...
March 9, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277878/effect-of-smoking-on-the-thickness-of-retinal-layers-in-healthy-smokers
#16
Rahmi Duman, Reşat Duman, Mehmet Cem Sabaner, Ersan Çetinkaya
PURPOSE: To compare the thicknesses of the retinal layers in smokers with those of non smoking healthy subjects using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred and eight subjects were included in the study. Two groups were separated as smokers and non-smokers. Both groups were chosen to be similar in terms of age and gender. SD-OCT images were generated with Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). An automated algorithm was developed to segment the macular retina into eight layers and quantitate the thickness of each layer for the fovea, parafovea and perifovea...
March 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28166658/sodium-perbarate-and-benzalkonium-chloride-induce-dna-damage-in-chang-conjunctival-epithelial-cells
#17
Huina Zhang, Han Wu, Jun Yang, Juan Ye
Content and objective: To investigate and compare the toxic effects of benzalkonium chloride (BAC) and new type oxidative preservative sodium perborate (NaBO3) on DNA damage, reactive oxygen species (ROS), and cell survival in immortalized human Chang conjunctival cells. MATERIAL AND METHODS: Cells were exposed to BAC and NaBO3 in concentrations of 0.00001% to 0.001% for 30 min. Cell viability was measured by the MTT test. Alkaline comet assay was used to detect DNA damage. Mitochondrial membrane potential (MMP), cell apoptosis, and reactive oxygen species production were detected by flow cytometry analysis...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28166657/ocular-surface-effects-of-repeated-application-of-povidone-iodine-in-patients-receiving-frequent-intravitreal-injections
#18
Habiba Saedon, Jennifer Nosek, Julian Phillips, Nirodhini Narendran, Yit C Yang
BACKGROUND: The aim of this study was to investigate the patient reported symptoms and objective signs of tear film and ocular surface abnormalities experienced by patients undergoing repeated exposure to povidone iodine as a consequence of requiring frequent intravitreal injections for wet macular degeneration. METHODS: This was a prospective study of consecutive patients who had received recent povidone 5% solution for sterile preparation of intravitreal injection less than 3 months prior to inclusion with a total of at least 3 intravitreal injections for macular degeneration...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067074/dynamic-thiol-disulphide-homeostasis-in-patients-with-basal-cell-carcinoma
#19
Duriye Deniz Demirseren, Cagla Cicek, Murat Alisik, Mustafa Erol Demirseren, Akın Aktaş, Ozcan Erel
BACKGROUND: The aim of this study is to measure and compare the dynamic thiol/disulphide homeostasis of patients with basal cell carcinoma and healthy subjects with a newly developed and original method. OBJECTIVE: Thirty four patients attending our outpatient clinic and clinically and histopathologically diagnosed as nodular basal cell carcinoma, and age and gender matched 30 healthy individuals have been involved in the study. Thiol/disulphide homeostasis tests have been measured with a novel automatic spectrophotometric method developed and the results have been compared statistically...
February 1, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28366074/intravitreal-bevacizumab-and-dexamethasone-implant-for-treatment-of-chronic-diabetic-macular-edema
#20
Emre Güler, Yüksel Totan, Fatma Betül Güragaç
OBJECTIVE: To evaluate anatomical and functional outcomes of intraviteal bevacizumab (IVB) in patients with chronic diabetic macular edema (DME), and the effectivity and safety of dexamethasone implant in those unresponsive to regular IVB treatment. METHODS: Thirty-five eyes of 35 patients (16 male and 19 female) with chronic DME (central foveal thickness (CFT)  > 275 μm, duration  > 6 months) received three injections of 2.5 mg IVB with six-week intervals...
June 2017: Cutaneous and Ocular Toxicology
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