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Cutaneous and Ocular Toxicology

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https://www.readbyqxmd.com/read/28504010/effects-of-selective-serotonin-reuptake-inhibitors-on-intraocular-pressure-and-anterior-segment-parameters-in-open-angle-eyes
#1
Gamze Uçan Gündüz, Neslihan Parmak Yener, Oğuzhan Kılınçel, Cem Gündüz
PURPOSE: To evaluate the short and long term effects of selective serotonin reuptake inhibitors (SSRIs) on intraocular pressure (IOP) and anterior segment parameters in open angle eyes. MATERIALS AND METHODS: This cross-sectional study included 325 eyes of 166 subjects. Subjects were divided into three groups; group 1 included 116 eyes of 58 patients receiving SSRIs for 1 week - 6 months, group 2 included 102 eyes of 53 patients receiving SSRIs for longer than 6 months, and group 3 included 107 eyes of 55 healthy subjects not receiving any drugs...
May 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28486855/the-effects-of-smoking-on-corneal-endothelial-cells-a-cross-sectional-study-on-a-population-from-isfahan-iran
#2
Khodayar Golabchi, Mohammad Ali Abtahi, Ali Salehi, Hamidreza Jahanbani-Ardakani, Sara Ghafari, Ziba Farajzadegan
PURPOSE: The aim of this study is to compare the effect of smoking in corneal endothelial cell number and morphology by specular microscopy on a non-smoker population. METHODS: Our cross-sectional study was performed on 150 participants from a non-smoker population. Non-contact specular microscopy (Tomey Corporation Inc., Nagoya, Japan) was performed in the center of the cornea of all subjects. The cell density (CD), average cell size (AVG), percent of hexagonality (HEX %), and central corneal thickness (CCT) were calculated and compared in both groups...
May 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28486821/oral-warfarin-affects-some-aspects-of-systemic-immunomodulation-with-topical-dinitrochlorobenzene-dncb-in-rats
#3
Aleksandra Popov Aleksandrov, Sandra Belij-Rammerstorfer, Ivana Mirkov, Vesna Subota, Jelena Kulas, Dragan Kataranovski, Milena Kataranovski
PURPOSE: The efficacy of topical dinitrochlorobenzene (DNCB) in treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model, was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy...
May 9, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28468509/effect-of-trospium-chloride-therapy-on-intraocular-pressure-and-tear-secretion-in-overactive-bladder-patients
#4
Ali Riza Turkoglu, Neslihan Parmak Yener, Soner Coban, Muhammet Guzelsoy, Ali Emul, Murat Demirbas, Hakan Demirci
PURPOSE: To investigate the effect of trospium chloride, which has an anticholinergic effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment. MATERIALS AND METHODS: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started...
May 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28468507/the-reduction-in-inflammation-and-impairment-in-wound-healing-by-using-strontium-chloride-hexahydrate
#5
Sibel Berksoy Hayta, Kasım Durmuş, Emine Elif Altuntaş, Esin Yıldız, Mehmet Hisarcıklıo, Melih Akyol
BACKGROUND: Numerous growth factors, cytokine, mitogen, and chemotactic factors are involved in wound healing. Even though inflammation is important for stimulation of proliferative phase, excessive inflammation also causes impairment in wound healing. Strontium salts suppress keratinocyte-induced TNF-alpha and interleukin 1 and 6 in in-vitro cultures. This study was conducted to determine the effects of administration of topical strontium chloride hexahydrate on wound healing through TNF-alpha and TGF-beta in surgical wound healing model of in-vivo rat skin...
May 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28427301/corneal-endothelial-changes-in-long-term-cannabinoid-users
#6
Nihat Polat, Birgul Cumurcu, Tongabay Cumurcu, İlknur Tuncer
PURPOSE: The aim of this study was to evaluate the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy. METHODS: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for 3 days or more per week over the past 1 year. 32 eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study...
April 20, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28423957/trends-in-culprit-drugs-and-clinical-entities-in-cutaneous-adverse-drug-reactions-a-retrospective-study
#7
Fang Wang, Yu-Kun Zhao, Minyi Li, Zhe Zhu, Xingqi Zhang
PURPOSE: Morbidity due to cutaneous adverse drug reactions (CADRs) is quite common. The specific culprit drugs change over time and clinicians must be kept informed with updated knowledge, thus preventing potential CADRs. This retrospective study is a survey of CADRs encountered in a hospital-based population in Southern China during three time intervals, from 1984 to 2015. MATERIALS AND METHODS: The clinical records were review of 306 patients with CADRs who were admitted to our hospital from 2011 to 2015...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28359163/pityriasis-rosea-like-eruption-induced-by-isotretinoin
#8
Gülhan Gürel, Sevinç Şahin, Emine Çölgeçen
Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Isotretinoin is usually used in the treatment of resistant, nodulocytic acne. We present a case of pityriasis rosea-like eruption induced by isotretinoin. To our knowledge, this is the second clinical case of pityriasis rosea-like eruption induced by isotretinoin.
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351170/effect-of-topiramate-on-choroidal-thickness-and-anterior-chamber-parameters-in-the-treatment-of-patients-with-migraine
#9
Mustafa Gok, Ozdemir Ozdemir
OBJECTIVE: To investigate the effects of topiramate on choroidal thickness and anterior chamber parameters using optical coherence tomography in the treatment of patients with migraine. METHODS: A total of 22 eyes of 22 adults (12 females, 10 males) diagnosed with migraine and scheduled to topiramate treatment for pain control were recruited in this prospective study. Choroidal thickness (CT), anterior chamber depth (ACD), anterior chamber angle (ACA), spherical refractive equivalent (SphEq) and intraocular pressure (IOP) measurements were recorded at baseline (prior the topiramate therapy), first and second month visits for the statistical analysis...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnostic
#10
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
April 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28397526/dynamic-thiol-disulphide-homeostasis-and-effects-of-smoking-on-homeostasis-parameters-in-patients-with-psoriasis
#11
Selma Emre, Duriye Deniz Demirseren, Murat Alisik, Akin Aktas, Salim Neselioglu, Ozcan Erel
PURPOSE: Recently, increased reactive oxygen species (ROS), reduced antioxidant capacity, and oxidative stress have been suggested in the pathogenesis of psoriasis. The aim of this study to evaluate the thiol/disulphide homeostasis in patients with psoriasis. MATERIALS AND METHODS: Ninety patients with psoriasis who did not receive any systemic treatment in the last 6 months were included in the study. Seventy-six age and gender-matched healthy volunteers served as control group...
April 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28393562/intravitreal-anti-vegf-treatment-for-retinopathy-of-prematurity-in-infants-with-active-adenoviral-keratoconjunctivitis
#12
Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC). MATERIAL AND METHODS: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP...
April 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#13
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children who is taking methylphenidate hydrochloride with Attention Deficit Hyperactivity Disorder. METHODS: Fifty seven consecutive patients who were diagnosed of Attention Deficit Hyperactivity Disorder (ADHD) and have been under oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) who have similar demographic features compared with the group 1, were involved as a control group...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376651/evaluation-of-the-effects-on-choroidal-thickness-of-bimatoprost-0-03-versus-a-brinzolamide-1-0-timolol-maleate-0-5-fixed-combination
#14
Nurettin Akyol, Ahmet Kalkisim, Adem Turk, Mehmet Kola, Halil Ibrahim Imamoglu
OBJECTIVE: To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG). METHODS: 67 eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA), and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28372461/decontamination-of-rat-and-human-skin-experimentally-contaminated-with-99mtc-201tl-131i-radionuclides-using-dermadecon-a-skin-decontamination-kit-an-efficacy-study
#15
Dhruv Kumar Nishad, Supriya Bhalla, Kushagra Khanna, Braj Gaurav Sharma, Harish Singh Rawat, Mittal Gaurav, Aseem Bhatnagar
Radioactive skin contamination is one of the most likely risks after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person contaminated should be decontaminated as soon as possible to reduce the damaging health effects of radiation. In present study, the decontamination efficiency of a developed skin decontamination kit 'Dermadecon' has been evaluated in animal models and human subjects using gamma scintigraphy...
April 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28366009/nickel-sensitivity-in-patients-with-gastroesophageal-reflux-disease
#16
Nurşad Aslan, Mesut Sezikli, Emel Erdal
OBJECTIVE: Various foods play important role in the pathogenesis of gastroesophageal reflux disease (GERD). These foods are shown to increase gastroesophageal reflux symptoms via various mechanisms and majority of these foods also contain nickel. The purpose of this study is to evaluate the relationship between Nickel sensitivity and GERD. MATERIAL AND METHODS: Fifty four patients diagnosed with GERD and 50 healthy volunteers who were admitted to our gastroenterology outpatient clinic were took part in the study...
April 2, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28351163/crp-relevance-in-clinical-assessment-of-chronic-spontaneous-urticaria-tunisian-patients
#17
Amal Maouia, Monia Youssef, Nadia Leban, Ahmed Noureddine Helal, Asma Kassab
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least 6 weeks. Multifactorial origin is suggested such as Oxidative stress. This latter may play a double role as a trigger and remnant agent. OBJECTIVES: The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: Desloratadine 5mg/day on these different parameters...
March 28, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277877/results-of-intravitreal-ranibizumab-treatment-for-retinopathy-of-prematurity-in-infants
#18
Emine Alyamaç Sukgen, Yusuf Koçluk
PURPOSE: To assess the results of intravitreal ranibizumab treatment for retinopathy of prematurity (ROP) in infants. METHODS: A single-institution, retrospective consecutive case series. RESULTS: Thirty-one patients who received ranibizumab treatment for ROP were evaluated in this study. The mean follow-up time was 14 ± 1.37 months. Vascularization of the peripheral retina had completed with delay in the majority of cases and also avascular areas were present in the peripheral retinas of five infants at one year of age...
March 27, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28277879/crude-4-methylcyclohexanemethanol-mchm-did-not-cause-skin-irritation-in-humans-in-48-h-patch-test
#19
Andrew D Monnot, Rachel M Novick, Dennis J Paustenbach
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9th, 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms are reported frequently in the background...
March 13, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28279080/effectiveness-of-heparin-eye-drops-in-paraquat-induced-ocular-injury
#20
Liu Jian-Wei, Li Xiu-Yun, Deng Ai-Jun
PURPOSE: To evaluate the efficacy of heparin eye drops in the treatment of paraquat-induced ocular surface injury. DESIGN AND METHODS: In this retrospective study, we included 25 patients (31 eyes) with paraquat-induced ocular surface injury, who attended the Affiliated Hospital of Weifang Medical University between October 2008 and October 2013. The patients were split into two groups according to whether or not received heparin eye drops. The clinical data were compared between the two groups, i...
March 9, 2017: Cutaneous and Ocular Toxicology
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