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Cardiovascular & Hematological Agents in Medicinal Chemistry

Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo
Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis...
February 3, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Silvia Riondino, Girolamo Del Monte, Federica Fratangeli, Fiorella Guadagni, Mario Roselli, Patrizia Ferroni
Neo-angiogenesis, a key step in cancer progression, is a highly regulated process, in which vascular endothelial growth factor (VEGF) plays a fundamental role, thus representing the most suitable anti-angiogenic target. In the last years, a number of anti-VEGF drugs have been developed and approved for therapeutic use, especially in combination with standard chemotherapy. VEGF, however, is not only crucial for physiological and pathological angiogenesis, but also for maintenance of vascular homeostasis, at a point that its pharmacological blockade may lead to endothelial dysfunction and adverse vascular effects, such as venous thromboembolism...
January 26, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Tahmineh Tabrizian, Lillie Floyd, Zia Shariat-Madar
BACKGROUND: Prolylcarboxypeptidase (PRCP, EC: is a cardioprotective protease. Plasma PRCP levels are elevated in type 2 diabetes (T2D) mellitus and cardiovascular diseases. OBJECTIVE: Since diabetic cardiomyopathy is a late complication of uncontrolled diabetes, we tested the hypothesis that glucose and free fatty acid related risk factors for T2D mellitus and cardiovascular disease may reduce the cardioprotective property of PRCP. METHOD: 0 We examined the effects of glucose, saturated fatty acids, and unsaturated fatty acids on PRCP expression in cultured H9c2 cells as an in-vitro model for pharmacological studies...
December 29, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Zeggwah Naoufel, Morad Hebi, Muhammad Ajebli, Jean B Michel, Muhammad Eddouks
BACKGROUND: The present study aims to evaluate the in vitro vasorelaxant effect of Artemisia herba alba (Ah) aqueous extract. METHOD: Aortic rings were isolated from spontaneously hypertensive rats and incubated in aqueous Ah extract at the following doses: 3, 5, 10 and 20 mg/ml. Incubation of aqueous Ah extract for 30 minutes produced a significant shift of the dose response curve to Norepinephrine (NE) (10-8 to 10-5 M) (p<0.001). RESULTS: Endothelium ablation significantly reduced the vasorelaxant effect of aqueous Ah extract (p<0...
December 15, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Daniel Petrovič, Miha Tibaut, Dušan Mekiš
Yearly, 13,2% of all deaths are attributable to coronary artery disease (CAD), which with 7.4 million deaths makes CAD leading cause of death in the world. In this review we discuss current knowledge in pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation - myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, ischemia-reperfusion injury, left-ventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, decision on reperfusion strategy, timing and cardiac protection by ischemic preconditioning, postconditioning and remote ischemic conditioning...
December 15, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Sarva Santhisudha, Tellamekala Sreekanth, Sudileti Murali, Bathal Vijaya Kumar, Meruva Anila Devi, Cirandur Suresh Reddy
BACKGROUND: One of the alarming difficulties in the field of hematology is the Coagulant disorders. Despite the availability of clinically proven existing anticoagulants, their limitations have prompted a continuous search for novel anticoagulants. OBJECTIVE: The primary objective of the study is to synthesize a series of 2-amino-4H-chromen-4-ylphosphonate derivatives and to test their anticoagulant activity depending on PT measurements con-sidering commercial heparin as positive control...
December 4, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Figueroa-Valverde Lauro, Maria López-Ramos, Marcela Rosas-Nexticapa, Maria Del Socorrob Herrera-Mesa, Francisco Díaz-Cedillo, Elodia García-Cervera, Eduardo Pool-Gómez, Tania Garcia-Camacho, Angel Aguilar-Villarino
BACKGROUND: There are data indicating that that several azonine-derivatives may exert effects on some biological system; however, there is very low information of the biological activity induced by this compounds on left ventricular pressure. OBJECTIVE: The aim of this study was synthesize and to evaluate the biological activity of new triazonine-derivative on left ventricular pressure. MATERIAL AND METHODS: The first stage involved 1) preparation of two azepine-benzamide derivatives (Z or E) by reaction of the nitrobenzoyl azide with adrenosterone; and 2) reaction of (Z)-azepine-benzamide derivative with ethylenediamine to form the triazonine derivative...
November 23, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Parmita Chowdhury, Rita Mahanta
BACKGROUND: This article is a study of adverse effects associated with the abuse of recreational drugs such as Anabolic Androgenic Steroids. Nandrolone Decanoate is one such drug often abused by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids has increased dramatically over the years. OBJECTIVE: The present study was conducted to investigate the impact of nandrolone decanoate when consumed at an abused dose, upon serum aldosterone concentration in albino mice...
November 21, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
V Mohanasrinivasan, C Devi Subathra, S Yogesh, A Govindaraj, S Naine Jemimah
An extracellular thrombolytic protease producing marine Streptomyces sp. VITYGM was isolated and characterized on the basis of morphological, biochemical, and molecular characterization. 16srDNA sequencing and BLAST search analysis of the sequence revealed close affiliation with Streptomyces genera and identified as Streptomyces violaceus VITYGM with 99% similarity. The primary screening for protease activity was observed by casein hydrolysis method followed by radial caseinolytic assay that showed the maximum zone of clearance of 12mm respectively...
November 4, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Valeria Hirschler, M Esteban, C González, C Molinari, L Castano
BACKGROUND: Studies in adults show that central obesity increases the likelihood of Type 2 diabetes (T2DM). OBJECTIVE: To determine the association between waist circumference (WC) and non-traditional risk factors such as magnesium (Mg), phosphorus, and uric acid in indigenous children living at high altitudes. METHODS: A total of 354 (166 M) indigenous school children, aged 9.6 + 2.3 years, were enrolled in a cross-sectional study in November 2011...
October 29, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Maria Campos, C Batista, N R Jesus, C M Silva, T P Silva
Cardiovascular patients frequently use herbal medicinal products, in order to contribute to the improvement of their chronic condition without medical intervention. However, they are likely to suffer from adverse effects from natural products and herb-drug interactions. This work aimed to alert cardiovascular patients and healthcare providers of the potential of occurrence of herb-drug interactions with cardiovascular therapy. Information obtained from the campaign "Aprender Saúde Entre as Plantas e os Medicamentos", carried out by the Observatory of Herb-Drug Interactions (www...
October 7, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Muharrem Akin, Thomas Skripuletz, L Christian Napp, Dominik Berliner, Ibrahim Akin, Arash Haghikia, Elvan Akin, Johann Bauersachs
Statins are the most widely prescribed drugs to reduce serum low density lipoprotein cholesterol (LDL-C) by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. LDL-C reduction is associated with a decreased risk of atherosclerotic cardiovascular disease (ASCVD), including cardiovascular disease (CVD) and stroke. Statins reduce LDL-C by 30 to 40%, and the combination with other lipid-lowering agents such as ezetimibe leads to a further reduction by 20 to 25%. However, even the combination of these two agents might not be sufficient in high risk patients to require aggressive LDL-C reduction...
July 27, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Pasquale Niscola, Andrea Tendas, Marco Giovannini, Adriana Costa, Daniela Venditti, Laura Volta, Luigi Malandruccolo, Stefania Sabbadini, Rosa Lasorella, Paolo de Fabritiis, Rita Cassetta, Alessiox Pio Perrotti
Pressure sores are a major complication in the bed-ridden older patient. In this report, we present the case of platelet rich plasma (PRP) application for the treatment of a pressure sore in an 88-year-old female affected by transfusion-dependent chronic inflammatory disease anemia associated with the congenital and inherited condition of thalassemic trait carrier. A weekly application schedule was planned at-home, given the patient's debilitation and her decreased performance status as well as personal and family difficulties to go as outpatients at our treatment center...
June 8, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Saad Syed Hussain, Alan H Tyroch, Debabrata Mukherjee
Anticoagulation therapy is indicated for management of various clinical conditions to prevent adverse events and introduction of direct oral anticoagulants (DOACs) has ushered in a new era in anticoagulation therapy. Major advantages of DOACS include fewer drug interactions and that they do not need periodic monitoring. Several patients who were not on anticoagulation before due to older age, polypharmacy/drug interaction concerns, and logistics of periodic monitoring are now on anticoagulation with DOACs. Despite their many advantages, a challenge while prescribing DOACs is very limited availability of specific reversal agents and lack of understanding or guidance about the treatment strategy in case of major life threatening bleeding or need for urgent surgery...
May 24, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
M Praveen Kumar, T N Raju, R Ravindar Naik
Diabetic patients are susceptible to the development of chronic health complications responsible for a significant increase in their morbidity and mortality. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of secondary complications of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of diabetic complications. Recently, considerable attention has been devoted to the search for phytochemical therapeutics...
May 18, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Yogita Dhas, Neetu Mishra, Joyita Banerjee
Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence of vitamin D deficiency is 70%-100% in the adult population. The main identified reason for vitamin D deficiency is the lack of appropriate sunlight exposure and no consumption (in case of vegetarian population) or less consumption of vitamin D containing diet (e...
April 26, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
V V Sathibabu Uddandrao, Parim Brahmanaidu, G Saravanan
Plants derived constituents with impending therapeutic values have been used long time to cure various diseases and disorders including Diabetes mellitus (DM). Many of the medicinal plants and herbs are also part of our diet as spices, vegetables and fruits. In recent years, there is growing evidence that plant-foods molecules, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of Diabetes mellitus. In this review, we addressed the potential efficacies of S-Allylcysteine (SAC), a sulfur containing amino acid, derived from garlic, on Diabetes mellitus and other disorders...
April 18, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
M Hebi, M Ajebli, N A Zeggwagh, M Eddouks
This study aims to evaluate the underlying mechanism of action involved in the hypotensive effect of Chamaemulum nobile L. (Cn) aqueous extract and in anesthetized Wistar rats. Lyophilized aqueous extract was administered in the jugular vein, arterial blood pressure and heart rate were measured in the carotide artery over 120 min of injection throughout an invasive direct blood pressure measuring procedure. Intravenous bolus injection of aqueous Cn extract at the doses of 50, 100 and 200 mg/kg produced a dose dependent reduction in arterial blood pressure and heart rate (p<0...
April 7, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Ana Rita Santos Estrela, Frederico Cerveira, Bárbara Regadas Correia, Ana Reis, Margarida Fardilha, Pedro Domingues, Rita Ferreira, M Rosário M Domingues
Hypovitaminosis D is a worldwide clinical problem, affecting populations in numerous ways. Several factors seem to affect vitamin D metabolism, including the suggestion that therapy with the lipid lowering HMG-CoA inhibitors might modulate vitamin D levels. However, the relationship between statins intake and serum levels of vitamin D is still controversial. The present work aimed to add new insights on the association between statins therapy, and more specifically the generation of statins, and the lipid profile in a population of 106 subjects treated with these HMG-CoA inhibitors...
February 11, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Aitbay Bulashev, Orken Akibekov, Sadybek Tokpan, Shynar Serikova, Gulmira Abulgazimova
OBJECTIVES: To study the hematological findings of dogs infected with echinococcosis and the possibility of using in vitro reared Echinococcus granulosus excretory-secretory antigen (ES-Ag) as a reagent for serological diagnosis of canine echinococcosis. METHODS: Eight dogs were infected orally with protoscoleces, extracted from ovine fertile hydatid cysts. Two additional dogs were infected with Cysticercus tenuicollis, obtained from infested sheep. The hematological parameters of dogs were determined with the ADVIA 2120i automatic hematology analyzer with a blood smear staining module...
2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
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