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Cardiovascular & Hematological Agents in Medicinal Chemistry

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https://www.readbyqxmd.com/read/28875835/the-biological-potentialsof-indian-traditional-medicine-curcumin-for-treating-human-diseases
#1
C S Sumathi
Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28875834/argemone-mexicana-a-boon-to-medicinal-and-pharmacological-approaches-in-current-scenario
#2
A Nancy, A Praveena
Nature is God's gift to human beings. Natural products are a source of new chemical diversity and are the choice of today's world. Nature itself gives remedy to all our health problems. The sources of natural product are plants, animals and microorganisms. Among them plant and its products are more reliable for its renewability and therefore, considered as fortunate thing for human welfare. Our traditional system of medicine which has been followed by our ancestors has its own impact on human life. Due to the inadequate knowledge many plant derived products (drugs) has not yet been explored to the society...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28875833/phytocompounds-as-potential-agents-to-treat-obesity-cardiovascular-ailments
#3
Balaji Meriga, Muni Swamy Ganjayi, Brahma Naidu Parim
Obesity is no longer considered as a cosmetic issue as it is a potential risk factor to develop hypertension, type-2 diabetes, cardio vascular diseases (CVDs), infertility, arthritis etc. Apart from genetic factors, changes in life styles, food and work habits have lead to alarming raise in obesity ailments in both developed and developing countries. The excess and unutilized food takenin is converted into lipid components, primarily triglycerides and is stored in the liver, adipose and other tissues; if the positive energy balance extends a longer period it will lead to overweight, obesity and CVDs...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28799493/association-between-apo-b-levels-in-mothers-and-in-their-pre-school-age-offspring
#4
Valeria Hirschler, Maximiliano Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff, Fernando Brites
OBJECTIVE: To determine the association between apo B levels in mothers and their pre-school offspring. METHODS: BMI, lipids, and apo B levels were obtained in mothers and their children in November 2015 in Buenos Aires. RESULTS: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39.2% (33) in mothers and 22.6%(19) in children, and the prevalence of obesity was 38...
August 11, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28707593/effects-of-some-indigenous-plants-of-north-karnataka-india-on-cardiovascular-and-glucose-regulatory-systems-in-diabetic-rats
#5
Kusal K Das, Kailash S Chadchan, R Chandramouli Reddy, M S Biradar, Pallavi S Kanthe, Bheemshetty S Pati, Jeevan G Ambekar, Ishwar B Bagoji, Swastika Das
BACKGROUND: The medicinal plants of north Karnataka, India are always researchers delight as many of these plants are rarely found in elsewhere other than this part of India. Kenaf leaves (Hibiscus cannabinus Linn, Pundi), Chick pea leaves (Cicer arietinum Linn, Chana) and Prickly lettuce leaves (Lactuca scariola Linn, Hattaraki.) are a few of these indigenous plants which are routinely consumed by the people as diet in this part of India. Various studies were done on these plants to find out some potential anti diabetic efficacies but reports are still not encouraging...
July 12, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28552062/discovery-of-chromen-7-yl-furan-2-carboxylate-as-a-potent-and-selective-factor-xia-inhibitor
#6
Rami Al-Horani, Ahmad J Obaidullah
Direct inhibition of coagulation factor XIa (FXIa) carries a significant promise for developing effective and safe anticoagulants. In this report, we studied 4-methyl-2-oxo-2H-chromen-7-yl furan-2-carboxylate 1, a coumarin derivative, for direct FXIa inhibition. This small molecule was found to inhibit FXIa with an IC50 value of 0.77 μM. Coumarin 1 also displayed a moderate-to-high selectivity for FXIa inhibition over other coagulation, digestive, and fibrinolysis serine proteases. Coumarin 1 selectively doubled APTT of human plasma at a concentration of 72 μM...
May 28, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28552061/polypharmacy-in-cardiovascular-medicine-problems-and-promises
#7
Mehran Abolbashari, Tracy E Macaulay, Thomas F Whayne, Debabrata Mukherjee, Sibu Saha
Polypharmacy is now a frequent aspect and reality of current medicine practice, driven by managing multiple comorbidities, especially in older adults. However and unfortunately, polypharmacy can expose patients to adverse drug reactions, and drug-drug or drug-disease interactions. On the other hand, clinicians are often hesitant to add new drugs to complex regimens even when recommended by evidence-based medicine and guidelines. In addition, there is frequently a failure to assess which medications might not be beneficial and may therefore be stopped...
May 28, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28552060/thiopurine-s-methyltransferase-as-a-pharmacogenetic-biomarker-significance-of-testing-and-review-of-major-methods
#8
Chingiz Asadov, Gunay Aliyeva, Kamala Mustafayeva
Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. Individual enzyme activity varies depending on the genetic polymorphisms of TPMT gene located at chromosome 6. Up to 14% of population is known to have a decreased enzyme activity, and if treated with standard doses of thiopurines, these individuals are at the high risk of severe adverse drug reactions (ADR) as myelosuppression, gastrointestinal intolerance, pancreatitis and hypersensitivity...
May 28, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28164751/pernicious-anemia-fundamental-and-practical-aspects-in-diagnosis
#9
Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo
Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis...
February 3, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28137223/anti-angiogenic-drugs-vascular-toxicity-and-thromboembolism-in-solid-cancer
#10
Silvia Riondino, Girolamo Del Monte, Federica Fratangeli, Fiorella Guadagni, Mario Roselli, Patrizia Ferroni
Neo-angiogenesis, a key step in cancer progression, is a highly regulated process, in which vascular endothelial growth factor (VEGF) plays a fundamental role, thus representing the most suitable anti-angiogenic target. In the last years, a number of anti-VEGF drugs have been developed and approved for therapeutic use, especially in combination with standard chemotherapy. VEGF, however, is not only crucial for physiological and pathological angiogenesis, but also for maintenance of vascular homeostasis, at a point that its pharmacological blockade may lead to endothelial dysfunction and adverse vascular effects, such as venous thromboembolism...
January 26, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27889993/experimental-theoretical-and-biological-activity-of-a-triazonine-derivative-on-left-ventricular-pressure
#11
Lauro Figueroa-Valverde, Maria Lopez-Ramos, Marcela Rosas-Nexticapa, Socorro Herrera-Meza, Francisco Diaz-Cedillo, Elodia Garcia-Cervera, Eduardo Pool-Gomez, Tania Garcia-Camacho, Angel Aguilar-Villarino
BACKGROUND: There are data indicating that several azonine-derivatives may exert effects on some biological systems; however, there is very low information on the biological activity induced by these compounds on left ventricular pressure. OBJECTIVE: The aim of this study was to synthesize and evaluate the biological activity of new triazoninederivative on left ventricular pressure. MATERIAL AND METHODS: The first stage involved: 1) preparation of two azepine-benzamide derivatives (Z or E) by reaction of the nitrobenzoyl azide with adrenosterone; and 2) reaction of (Z)-azepine-benzamide derivative with ethylenediamine to form the triazonine derivative...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27823551/in-vitro-thrombolytic-potential-of-actinoprotease-from-marine-streptomyces-violaceus-vitygm
#12
V Mohanasrinivasan, S Yogesh, A Govindaraj, S Jemimah Naine, C Subathra Devi
Back ground: One of the most prevailing diseases that required effective drug as therapeutic purposes is cardiac related illness includes myocardial infarction Current scenario makes enzyme to raises their sector towards therapeutic as effective active component for such diseases. OBJECTIVES: The main aim of the study was to isolate, screen, characterize and produce an extracellular thrombolytic protease from marine actinomycetes. METHODS: Marine actinomycete was isolated and characterized on the basis of morphological, biochemical, and molecular characterization...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27470008/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-impact-of-pcsk9-on-major-adverse-cardiac-and-cerebrovascular-events
#13
REVIEW
Muharrem Akin, Thomas Skripuletz, L Christian Napp, Dominik Berliner, Ibrahim Akin, Arash Haghikia, Elvan Akin, Johann Bauersachs
Statins are the most widely prescribed drugs to reduce serum low density lipoprotein cholesterol (LDL-C) by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. LDL-C reduction is associated with a decreased risk of atherosclerotic cardiovascular disease (ASCVD), including cardiovascular disease (CVD) and stroke. Statins reduce LDL-C by 30 to 40%, and the combination with other lipid-lowering agents such as ezetimibe leads to a further reduction by 20 to 25%. However, even the combination of these two agents might not be sufficient in high risk patients to require aggressive LDL-C reduction...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27292011/at-home-application-of-autologous-platelet-rich-plasma-as-treatment-for-pressure-sore-and-related-anemia
#14
Andrea Tendas, Pasquale Niscola, Marco Giovannini, Adriana Costa, Daniela Venditti, Laura Volta, Luigi Malandruccolo, Stefania Sabbadini, Rosa Lasorella, Paolo de Fabritiis, Rita Cassetta, Alessio P Perrotti
Pressure sores are a major complication in the bed-ridden older patient. In this report, we present the case of platelet rich plasma (PRP) application for the treatment of a pressure sore in an 88-year-old female affected by transfusion-dependent chronic inflammatory disease anemia associated with the congenital and inherited condition of thalassemic trait carrier. A weekly application schedule was planned athome, given the patient's debilitation and her decreased performance status as well as personal and family difficulties to go as outpatients at our treatment center...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27215215/reversal-of-newer-direct-oral-anticoagulant-drugs-doacs
#15
REVIEW
Saad S Hussain, Alan H Tyroch, Debabrata Mukherjee
Anticoagulation therapy is indicated for management of various clinical conditions to prevent adverse events and introduction of direct oral anticoagulants (DOACs) has ushered in a new era in anticoagulation therapy. Major advantages of DOACS include fewer drug interactions and that they do not need periodic monitoring. Several patients who were not on anticoagulation before due to older age, polypharmacy/drug interaction concerns, and logistics of periodic monitoring are now on anticoagulation with DOACs. Despite their many advantages, a challenge while prescribing DOACs is very limited availability of specific reversal agents and lack of understanding or guidance about the treatment strategy in case of major life threatening bleeding or need for urgent surgery...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27114101/vitamin-d-deficiency-and-oxidative-stress-in-type-2-diabetic-population-of-india
#16
REVIEW
Yogita Dhas, Neetu Mishra, Joyita Banerjee
Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence of vitamin D deficiency is 70%-100% in the adult population. The main identified reason for vitamin D deficiency is the lack of appropriate sunlight exposure and no consumption (in case of vegetarian population) or less consumption of vitamin D containing diet (e...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28034286/altered-prolylcarboxypeptidase-expression-and-function-in-response-to-different-risk-factors-of-diabetes
#17
Tahmineh Tabrizian, Lillie Floyd, Zia Shariat-Madar
BACKGROUND: Prolylcarboxypeptidase (PRCP, EC:3.4.16.2) is a cardioprotective protease. Plasma PRCP levels are elevated in type 2 diabetes (T2D) mellitus and cardiovascular diseases. OBJECTIVE: Since diabetic cardiomyopathy is a late complication of uncontrolled diabetes, we tested the hypothesis that glucose and free fatty acid related risk factors for T2D mellitus and cardiovascular disease may reduce the cardioprotective property of PRCP. METHOD: 0 We examined the effects of glucose, saturated fatty acids, and unsaturated fatty acids on PRCP expression in cultured H9c2 cells as an in-vitro model for pharmacological studies...
December 29, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27993120/in-vitro-vasorelaxant-effect-of-artemisia-herba-alba-asso-in-spontaneously-hypertensive-rats
#18
Zeggwah Naoufel, Morad Hebi, Muhammad Ajebli, Jean B Michel, Muhammad Eddouks
BACKGROUND: The present study aims to evaluate the in vitro vasorelaxant effect of Artemisia herba alba (Ah) aqueous extract. METHOD: Aortic rings were isolated from spontaneously hypertensive rats and incubated in aqueous Ah extract at the following doses: 3, 5, 10 and 20 mg/ml. Incubation of aqueous Ah extract for 30 minutes produced a significant shift of the dose response curve to Norepinephrine (NE) (10-8 to 10-5 M) (p<0.001). RESULTS: Endothelium ablation significantly reduced the vasorelaxant effect of aqueous Ah extract (p<0...
December 15, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27993119/pathophysiology-of-myocardial-infarction-and-acute-management-strategies
#19
Daniel Petrovič, Miha Tibaut, Dušan Mekiš
Yearly, 13,2% of all deaths are attributable to coronary artery disease (CAD), which with 7.4 million deaths makes CAD leading cause of death in the world. In this review we discuss current knowledge in pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation - myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, ischemia-reperfusion injury, left-ventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, decision on reperfusion strategy, timing and cardiac protection by ischemic preconditioning, postconditioning and remote ischemic conditioning...
December 15, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27917720/ultrasound-promoted-synthesis-and-anticoagulant-activity-of-2-amino-4h-chromen-4-ylphosphonates
#20
Sarva Santhisudha, Tellamekala Sreekanth, Sudileti Murali, Bathal Vijaya Kumar, Meruva Anila Devi, Cirandur Suresh Reddy
BACKGROUND: One of the alarming difficulties in the field of hematology is the Coagulant disorders. Despite the availability of clinically proven existing anticoagulants, their limitations have prompted a continuous search for novel anticoagulants. OBJECTIVE: The primary objective of the study is to synthesize a series of 2-amino-4H-chromen-4-ylphosphonate derivatives and to test their anticoagulant activity depending on PT measurements con-sidering commercial heparin as positive control...
December 4, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
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