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Cardiovascular & Hematological Agents in Medicinal Chemistry

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https://www.readbyqxmd.com/read/30539703/idiopathic-cyclic-edema-a-frustrating-and-poorly-understood-clinical-problem
#1
Thomas F Whayne, Mary Beth Fisher
Idiopathic edema (IE), is a syndrome involving real or perceived weight gain secondary to the pathological retention of fluid. This syndrome of generalized edema is almost solely reported in women. The diagnosis of IE is one of exclusion and requires a careful history, physical exam, and clinical suspicion. The aim of this article is to provide a comprehensive review of the available literature in order to attempt to define IE, identify the possible causes, review the proposed pathophysiology, and discuss potential treatment options...
December 11, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30539702/effect-of-flavonoid-rich-extract-of-tamarix-articulata-vahl-on-glucose-and-lipid-metabolism-in-normal-and-diabetic-rats
#2
Morad Hebi, Lhoussaine Hajji, Mohamed Eddouks
OBJECTIVE: The present study was carried out in order to evaluate the antidiabetic and antihyperlipidemic potential of flavonoid-rich extract of Tamarix articulata (FRETA) in both normal and streptozotocin (STZ)-induced diabetic rats. MATERIAL AND METHODS: Normal and diabetic rats were treated with the FRETA for 7 days. At the end of treatment, a range of parameters were tested including blood lipid profile, histopathological changes in both liver and pancreas and oral glucose tolerance test (OGTT)...
December 11, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30526472/the-beneficial-therapy-with-colchicine-for-atherosclerosis-via-anti-inflammation-and-decrease-in-hypertriglyceridemia
#3
Michael Spartalis, Eleftherios Spartalis, Eleni Tzatzaki, Diamantis I Tsilimigras, Demetrios Moris, Christos Kontogiannis, Vaios Vasileios Kaminiotis, Stavroula A Paschou, Sofia Chatzidou, Gerasimos Siasos, Vassilis Voudris, Dimitrios C Iliopoulos
BACKGROUND: Lipid-lowering therapy and control of cardiovascular risk factors are the current recommendations of atherosclerotic disease management. Despite optimal treatment though the rate of acute coronary syndrome events remains high. Inflammation plays an essential role in the pathophysiology of atherosclerotic plaque formation, progression and rupture, which conclusively causes acute clinical episodes. OBJECTIVE: This review aims to give a conceptual description of the potential therapeutic benefits and effects of colchicine in inflammation-mediated atherosclerotic disease and hypertriglyceridemia...
December 10, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30394217/reduction-in-vasa-vasorum-angiogenesis-by-lp-pla2-selective-inhibitor-through-the-hif-1%C3%AE-and-vegf-expression-under-dyslipidemic-conditions-in-atherosclerosis-pathogenesis
#4
Teuku Heriansyah, Nafisatuzzamrudah, Fitria N Aini, Muhammad Ridwan, Rozah F Primardhika, Maya D Wijayanti, Rachmad S Bekti, Titin A Wihastuti
Atherosclerosis is a chronic inflammatory disease which may lead to major cardiovascular events. The primary cause of atherosclerosis is Dyslipidemia. The increased level of lipid profile triggers endothelial dysfunction. This results in inflammation with the recruitment of monocyte, macrophage, T lymphocyte, and Mast cells secreted by an Lp-PLA2 enzyme which causes binding between macrophage and oxidized LDL. This binding results in the formation of foam cells and also the migration of smooth muscle cells...
November 5, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30210008/comparison-and-impact-of-short-term-use-of-some-non-aspirin-nsaids-on-bleeding-time-of-mice
#5
Yedy Purwandi Sukmawan
BACKGROUND: Non-Steroidal Anti Inflammation Drugs (NSAIDs) are a class of drugs that have been shown to be effective in reducing pain and the most prescribing around the world. But this group impair hematological aspects that may lead to life-threatening. OBJECTIVE: The objective of the study is to determine the comparison and impact of short-term use of some non-aspirin NSAIDs on bleeding time parameter. METHOD: Each groups contained 4 animals were given the test drugs (normal group without any treatment, ketoprofen 0,26 mg/ 20 g BW of mice twice daily, ketorolac 0,078 mg/ 20 g BW of mice twice daily, diclofenac sodium 0,13 mg/ 20 g BW of mice twice daily, piroxicam 0,052 mg/ 20 g BW of mice once daily, mefenamic acid 1,3 mg/ 20 g BW of mice thrice daily, meloxicam 0,039 mg/ 20 g BW of mice once daily, celecoxib 0,52 mg/ 20 g BW of mice once daily, ibuprofen 1,04 mg/ 20 g BW of mice thrice daily and paracetamol 1,3 mg/ 20 g BW of mice thrice daily) for 5 days...
September 12, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30039765/thromboxane-a-synthase-a-new-target-for-the-treatment-of-cardiovascular-diseases
#6
Dinara F Mesitskaya, Abram L Syrkin, Marina G Aksenova, Yong Zhang, Andrey A Zamyatnin, Philipp Yu Kopylov
Atherothrombosis-related diseases are one of the world's leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence, and suggests that systematic works in this area are creating new and promising opportunities in the treatment of patients with cardiovascular diseases...
July 23, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29879893/perception-of-patients-regarding-burdens-and-benefits-of-vitamin-k-antagonists-among-patients-with-nonvalvular-atrial-fibrillation
#7
Carlos Escobar, Vivencio Barrios, Luis Prieto, Jose Maria Lobos, Jose Polo, Diego Vargas, Paula Study Team
BACKGROUND: Achieving a good satisfaction with anticoagulant treatment should be a target in atrial fibrillation (AF) patients. OBJECTIVE: To ascertain the perception of patients regarding burdens and benefits of anticoagulation with vitamin K antagonists (VKA). METHODS: This was a multicenter cross-sectional/retrospective study conducted throughout Spain, in which AF patients taking VKA during the last year, attended at primary care setting were included...
June 7, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30215327/pegylated-naloxone-in-the-treatment-of-persistent-opioid-induced-constipation-in-patients-with-hematological-malignancies
#8
Gregorio Antonio Brunetti, Giovanna Palumbo, Giorgia Annechini, Michelina Santopietro, Andrea Tendas, Pasquale Niscola, Claudio Cartoni
No abstract text is available yet for this article.
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30215326/cardiovascular-and-hematological-medicine-in-2018-advances-and-insights
#9
Debabrata Mukherjee
No abstract text is available yet for this article.
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29804539/free-fatty-acids-circulating-contributors-of-metabolic-syndrome
#10
Chase Suiter, Santu K Singha, Rozita Khalili, Zia Shariat-Madar
Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that increased Free Fatty Acids (FFAs) are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues within the cardiovascular system and increased plasma concentrations of FFAs has been reported...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29737263/glucose-lowering-activity-of-the-aqueous-extract-of-warionia-saharae-in-normal-and-diabetic-rats
#11
Morad Hebi, Mohamed Eddouks
BACKGROUND: Warionia saharae is a medicinal plant used in the Morocco for the treatment of diabetes mellitus. OBJECTIVE: The aim of the study was to assess the effect of the aqueous extract of this plant on blood glucose levels in diabetic rats. METHOD: The current study was carried out to investigate the effect of a single dose and daily oral administration for 15 days of the Aerial Part Aqueous Extract (A.P.A.E) of Warionia saharae (W. saharae) at a dose of 5 mg/kg body weight on blood glucose levels and the histopathological changes in liver and pancreas both in normal and streptozotocin-induced diabetic rats (STZ)...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29607790/protective-effects-of-diuretics-against-the-development-of-cardiovascular-disease-in-patients-with-chronic-kidney-disease-a-systematic-review
#12
Akinori Aomatsu, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Cardiovascular disease is one of the most important risk factors for mortality and morbidity in patients with Chronic Kidney Disease (CKD). This systematic review focuses on the protective effects of diuretics against the development of cardiovascular disease in patients with CKD. Among various kinds of diuretics, spironolactone, a mineralocorticoid receptor antagonist, has been shown to have protective effects against cardiovascular disease in patients with all stages of CKD, including predialysis, hemodialysis, and peritoneal dialysis...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29532764/entresto-a-new-panacea-for-heart-failure
#13
Peter Khalil, Ghazal Kabbach, Sarmad Said, Debabrata Mukherjee
Heart Failure (HF) is one of the main healthcare burdens in the United States and in the world. Many drugs are approved and used in practice for management of this condition; including beta blockers, diuretics, aldosterone antagonists, Angiotensin Converting Enzyme Inhibitors (ACEI's), and Angiotensin Receptor Blockers (ARBs). Recently, the Food and Drug Administration (FDA) approved a drug with brand name Entresto (Sacubitril/Valsartan or LCZ696), an angiotensin receptor neprilysin inhibitor for the use in Heart Failure with Reduced Ejection Fraction (HFrEF) patients instead of ACEI's and ARBs...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29485011/fibrinolytic-protease-from-marine-streptomyces-rubiginosus-vitpss1
#14
Priyanka Verma, Shruti Chatterjee, Merlyn S Keziah, Subathra C Devi
INTRODUCTION: Fibrinolytic enzymes must currently originate a significant product in the arena of medical research. Very limited studies are stated on fibrinolyticenzyme production from actinomycetes. METHODS: Streptomyces sp. isolated from marine soil was chosen to optimize its fibrinolytic protease production.16s rRNA sequencing confirmed the isolated potent strain to be Streptomyces rubiginosus VITPSS1. A fibrinolytic protease was then purified from Streptomyces rubiginosus VITPSS1, with the target of producing a cost effective feasible enzyme from a potential actinomycete...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29357809/coagonist-of-glp-1-and-glucagon-receptor-ameliorates-development-of-non-alcoholic-fatty-liver-disease
#15
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Hiren Patel, Dheerendra Pandey, Dipam Patel, Ramchandra Ranvir, Shekhar Kadam, Rajesh Bahekar, Mukul Jain
BACKGROUND: Obesity, diabetes and dyslipidemica are the key pathogenic stimulus that enhances progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Coagonist of Glucagon Like- Peptide-1 (GLP-1) Receptor (GLP-1R) and Glucagon Receptor (GCGR) are being evaluated for obesity and diabetes. GLP-1 analogs have shown to reverse diabetes and obesity. Glucagon treatment reduces lipids after acute and chronic treatment. OBJECTIVE: In this study, we have investigated the effect of co-agonist on the prevention of NAFLD induced by long-term feeding of High Fat Diet (HFD)...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29299990/aqueous-extract-of-argania-spinosa-l-fruits-ameliorates-diabetes-in-streptozotocin-induced-diabetic-rats
#16
Morad Hebi, Farid Khallouki, E L Haidani A, Mohamed Eddouks
INTRODUCTION: The argan tree (Argania spinosa L.) is an endemic species from south-western Morocco. Argan-based preparations have been widely used in Moroccan traditional medicine for their biological properties including diabetes especially argan oil. However, the antihypergycemic effect of the pericarp of A. spinosa fruit has never been evaluated. OBJECTIVE: The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of aqueous extract of pericarp of Argania spinosa fruit (A...
2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29219060/nattokinase-an-updated-critical-review-on-challenges-and-perspectives
#17
Ethiraj Selvarajan, Niharika Bhatnagar
Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT is a well studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the com-plete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders...
December 7, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28799493/association-between-apo-b-levels-in-mothers-and-in-their-pre-school-age-offspring
#18
Valeria Hirschler, Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff, Fernando Brites
OBJECTIVE: The study aims to determine the association between apo B levels in mothers and their pre-school offspring. METHODS: Anthropometric measurement (e.g. BMI), lipids, lipoproteins, and apolipoproteins (e.g. apo B) levels in mothers and their children were obtained in November 2015 in Buenos Aires. RESULTS: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28707593/effects-of-some-indigenous-plants-of-north-karnataka-india-on-cardiovascular-and-glucose-regulatory-systems-in-alloxan-induced-diabetic-rats
#19
Kusal K Das, Kailash S Chadchan, R Chandramouli Reddy, M S Biradar, Pallavi S Kanthe, Bheemshetty S Patil, Jeevan G Ambekar, Ishwar B Bagoji, Swastika Das
BACKGROUND: Kenaf (Hibiscus cannabinus Linn, Pundi), Chick pea (Cicer arietinum Linn, Chana) and Prickly lettuce (Lactuca scariola Linn, Hattaraki) leaves are a few of indigenous plants which are routinely consumed by the people of north Karnataka in the diet. Studies on these plants showed some potential anti-diabetic efficacies. OBJECTIVES: To examine the effect of leaves extracts of Hibiscus cannabinus Linn, Cicer arietinum Linn and Lactuca scariola Linn on cardiovascular integrity, glucose homeostasis and oxygen sensing cell signaling mechanisms in alloxan induced diabetic rats...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28552062/discovery-of-chromen-7-yl-furan-2-carboxylate-as-a-potent-and-selective-factor-xia-inhibitor
#20
Ahmad J Obaidullah, Rami A Al-Horani
BACKGROUND: Direct inhibition of coagulation factor XIa (FXIa) carries a significant promise for developing effective and safe anticoagulants. METHOD: In this report, we studied 4-methyl-2-oxo-2H-chromen-7-yl furan-2-carboxylate 1, a coumarin derivative, for direct FXIa inhibition. RESULTS: This small molecule was found to inhibit FXIa with an IC50 value of 0.77 µM. Coumarin 1 also displayed a moderate-to-high selectivity for FXIa inhibition over other coagulation, digestive, and fibrinolysis serine proteases...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
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