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Cardiovascular & Hematological Agents in Medicinal Chemistry

Dinara F Mesitskaya, Abram L Syrkin, Marina G Aksenova, Yong Zhang, Andrey A Zamyatnin, Philipp Yu Kopylov
Atherothrombosis-related diseases are one of the world's leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence, and suggests that systematic works in this area are creating new and promising opportunities in the treatment of patients with cardiovascular diseases...
July 23, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Carlos Escobar, Vivencio Barrios, Luis Prieto, Jose Maria Lobos, Jose Polo, Diego Vargas, Paula Study Team
BACKGROUND: Achieving a good satisfaction with anticoagulant treatment should be a target in atrial fibrillation (AF) patients. OBJECTIVE: To ascertain the perception of patients regarding burdens and benefits of anticoagulation with vitamin K antagonists (VKA). METHODS: This was a multicenter cross-sectional/retrospective study conducted throughout Spain, in which AF patients taking VKA during the last year, attended at primary care setting were included...
June 7, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Chase Suiter, Santu K Singha, Rozita Khalilli, Zia Shariat-Madar
Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that increased free fatty acids (FFAs) are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues within the cardiovascular system and increased plasma concentrations of FFAs have been reported...
May 27, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Mohamed Eddouks, Morad Hebi
The current study was carried out to investigate the effect of a single dose and daily oral administration for 15 days of the aerial part aqueous extract (A.P.A.E) of Warionia saharae (W. saharae) at a dose of 5 mg/kg body weight on blood glucose levels and the histopathological changes in liver and pancreas both in normal and streptozotocin-induced diabetic rats (STZ). Also, the effect of this extract to improve glucose tolerance in normal rats was demonstrated. Single oral administration of W. saharae A.P...
April 25, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Akinori Aomatsu, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Cardiovascular disease is one of the most important risk factors for mortality and morbidity in patients with chronic kidney disease (CKD). This systematic review focuses on the protective effects of diuretics against the development of cardiovascular disease in patients with CKD. Among various kinds of diuretics, spironolactone, a mineralocorticoid receptor antagonist, has been shown to have protective effects against cardiovascular disease in patients with all stages of CKD, including pre-dialysis, hemodialysis, and peritoneal dialysis...
April 2, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Peter H Khalil, Ghazal Kabbach, Debabrata Mukherjee, Sarmad Said
Heart Failure (HF) is one of the main health care burdens in the United States and in the world. Many drugs are approved and used in practice for management of this condition; including beta blockers, diuretics, aldosterone antagonists, angiotensin converting enzyme inhibitors (ACEI's), and angiotensin receptor blockers (ARBs). Recently, the Food and Drug Administration (FDA) approved a drug with brand name Entresto (Sacubitril/Valsartan or LCZ696), an angiotensin receptor neprilysin inhibitor for the use in Heart Failure with Reduced Ejection Fraction (HFrEF) patients instead of ACEI's and ARBs...
March 13, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
C Subathra Devi, V Mohanasrinivasan, Priyanka Devi Verma, Shruthi Chaterjee, S Merlyn Keziah
Fibrinolytic enzymes must currently originate a significant product in the arena of medical research. Very limited studies are stated on fibrinolyticenzyme production from actinomycetes.Streptomyces sp. isolated from marine soil was chosen to optimize its fibrinolytic protease production. 16s rRNA sequencing confirmed the isolated potent strain to be Streptomyces rubiginosus VITPSSM. A fibrinolytic protease was then purified from Streptomyces rubiginosus VITPSSM, with the target of producing a cost effective feasible enzyme from a potential actinomycete...
February 26, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Hiren Patel, Dheerendra Pandey, Dipam Patel, Ramchandra Ranvir, Shekhar Kadam, Rajesh Bahekar, Mukul Jain
Background-Obesity, diabetes and dyslipidemic are the key pathogenic stimulus that enhances progression of non-alcoholic fatty liver disease (NAFLD). Coagonist of glucagon like-peptide-1 (GLP-1) receptor (GLP-1R) and glucagon receptor (GCGR) are being evaluated for obesity and diabetes. GLP-1 analogues have shown to reverse diabetes and obesity. Glucagon treatment reduces lipids after acute and chronic treatment. Objective-In this study, we have investigated the effect of coagonist on prevention of NAFLD induced by long-term feeding of high fat diet (HFD)...
January 18, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Mohamed Eddouks, Hebi Morad
INTRODUCTION: The argan tree (Argania spinosa L.) is an endemic species from south-western Morocco. Argan-based preparations have been widely used in Moroccan traditional medicine for their biological properties including diabetes especially argan oil. However, the antihypergycemic effect of the pericarp of A. spinosa fruit has never been evaluated. OBJECTIVE: The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of aqueous extract of pericarp of Argania spinosa fruit (A...
January 3, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Ethiraj Selvarajan, Niharika Bhatnagar
Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT is a well studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the com-plete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders...
December 7, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Valeria Hirschler, Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff, Fernando Brites
OBJECTIVE: The study aims to determine the association between apo B levels in mothers and their pre-school offspring. METHODS: Anthropometric measurement (e.g. BMI), lipids, lipoproteins, and apolipoproteins (e.g. apo B) levels in mothers and their children were obtained in November 2015 in Buenos Aires. RESULTS: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Kusal K Das, Kailash S Chadchan, R Chandramouli Reddy, M S Biradar, Pallavi S Kanthe, Bheemshetty S Patil, Jeevan G Ambekar, Ishwar B Bagoji, Swastika Das
BACKGROUND: Kenaf (Hibiscus cannabinus Linn, Pundi), Chick pea (Cicer arietinum Linn, Chana) and Prickly lettuce (Lactuca scariola Linn, Hattaraki) leaves are a few of indigenous plants which are routinely consumed by the people of north Karnataka in the diet. Studies on these plants showed some potential anti-diabetic efficacies. OBJECTIVES: To examine the effect of leaves extracts of Hibiscus cannabinus Linn, Cicer arietinum Linn and Lactuca scariola Linn on cardiovascular integrity, glucose homeostasis and oxygen sensing cell signaling mechanisms in alloxan induced diabetic rats...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Ahmad J Obaidullah, Rami A Al-Horani
BACKGROUND: Direct inhibition of coagulation factor XIa (FXIa) carries a significant promise for developing effective and safe anticoagulants. METHOD: In this report, we studied 4-methyl-2-oxo-2H-chromen-7-yl furan-2-carboxylate 1, a coumarin derivative, for direct FXIa inhibition. RESULTS: This small molecule was found to inhibit FXIa with an IC50 value of 0.77 µM. Coumarin 1 also displayed a moderate-to-high selectivity for FXIa inhibition over other coagulation, digestive, and fibrinolysis serine proteases...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Mehran Abolbashari, Tracy E Macaulay, Thomas F Whayne, Debabrata Mukherjee, Sibu Saha
BACKGROUND: Polypharmacy is now a frequent aspect and reality of current medicine practice, driven by managing multiple comorbidities, especially in older adults. However and unfortunately, polypharmacy can expose patients to adverse drug reactions, and drug-drug or drug-disease interactions. On the other hand, clinicians are often hesitant to add new drugs to complex regimens even when recommended by evidence-based medicine and guidelines. In addition, there is frequently a failure to assess which medications might not be beneficial and may therefore be stopped...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Chingiz Asadov, Gunay Aliyeva, Kamala Mustafayeva
BACKGROUND: Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. Individual enzyme activity varies depending on the genetic polymorphisms of TPMT gene located at chromosome 6. Up to 14% of population is known to have a decreased enzyme activity, and if treated with standard doses of thiopurines, these individuals are at a high risk of severe Adverse Drug Reactions (ADR) as myelosuppression, gastrointestinal intolerance, pancreatitis and hypersensitivity...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo
BACKGROUND: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. CONCLUSION: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis...
November 8, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Ramavat Ravindhar Naik, Praveen Kumar Munipally, Turlapati Nagaraju
Diabetes mellitus (DM) is a constant and illimitable metabolic disorder that can happen even at a young age due to the virtual absence of naturally acting insulin, which uptakes and accumulates glucose; thereby reduce the use of glucose. In the present study, we evaluated the neuroprotective efficacy of andrographolide on streptozotocin (STZ) induced diabetic Sprague dawley rats. Diabetes was induced by intraperitonial injection of STZ (45 mg/kg B.W) in Sprague dawley rats. Andrographolide (2.5 mg/kg B.W) was administered orally to diabetic rats and Glibenclamide (25mg/kg B...
October 26, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
C S Sumathi, P Rajesh, V. Rajesh Kannan
Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
A Nancy, A Praveena
Nature is God's gift to human beings. Natural products are a source of new chemical diversity and are the choice of today's world. Nature itself gives remedy to all our health problems. The sources of natural product are plants, animals and microorganisms. Among them plant and its products are more reliable for its renewability and therefore, considered as fortunate thing for human welfare. Our traditional system of medicine which has been followed by our ancestors has its own impact on human life. Due to the inadequate knowledge many plant derived products (drugs) has not yet been explored to the society...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
Balaji Meriga, Muni Swamy Ganjayi, Brahma Naidu Parim
Obesity is no longer considered as a cosmetic issue as it is a potential risk factor to develop hypertension, type-2 diabetes, cardio vascular diseases (CVDs), infertility, arthritis etc. Apart from genetic factors, changes in life styles, food and work habits have lead to alarming raise in obesity ailments in both developed and developing countries. The excess and unutilized food takenin is converted into lipid components, primarily triglycerides and is stored in the liver, adipose and other tissues; if the positive energy balance extends a longer period it will lead to overweight, obesity and CVDs...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
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