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Recent Patents on Anti-infective Drug Discovery

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https://www.readbyqxmd.com/read/27784230/targets-and-patented-drugs-for-chemotherapy-of-chagas-disease-in-the-last-15-years-period
#1
Vilma G Duschak
The American trypanosomiasis, Chagas disease, is a parasitic infection typically spread by triatomine vectors affecting millions of people all over Latin America. Existing chemotherapy is centered on the nitroaromatic compounds benznidazole and nifurtimox that provide unsatisfactory results and substantial side effects. So, the finding and exploration of novel ways to challenge this neglected disease is a main priority. The biologic and biochemical progress in the scientific knowledge of Trypanosoma cruzi in the period comprising the last 15-years, has increased the identification of multiple targets for Chagas´ disease chemotherapy...
October 24, 2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27527725/correlation-between-qace-and-qace%C3%AE-1-efflux-pump-genes-antibiotic-and-disinfectant-resistant-among-clinical-isolates-of-e-coli
#2
Hossein Kazemian, Maryam Shafaati, Mohammadali Boroumand, Jamileh Nowroozi, Pouya Amiri
INTRODUCTION: Antiseptics and disinfectants has been used widely in hospitals and other health care settings to control the growth of these microorganisms. However, some disinfectants resistant strains were reported. The objectives of our study were to evaluate correlation between the efflux pump genes, drugs and disinfectant resistant among clinical isolates of E.coli. . METHODS: A total of 102 of E. coli strains were isolated from urine sample of hospitalized patients...
August 14, 2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27527726/detection-of-blakpc-and-blages-carbapenemase-genes-in-klebsiella-pneumoniae-isolated-from-hospitalized-patients-in-kashan-iran
#3
Mohammad Zibaei, Farzaneh Firoozeh, Mehdi Agha-Seyed Hosseini, Ahmad Piroozmand
Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are among highly antimicrobial resistant gram negative bacteria and infections due to them are an increasingly major health problem worldwide. In this study we have detected the blaKPC and blaGES carbapenemase genes and integron class 1 in Klebsiella pneumoniae isolated from hospitalized patient in Kashan, Iran. In a cross-sectional study, a total of 181 K. pneumoniae isolates were recovered K. pneumoniae from clinical specimens during November 2013 to October 2014...
August 13, 2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27291248/complement-3-receptor-expression-in-individuals-with-type-2-diabetes
#4
Judy Ly, Devin Morris, Minette Lagman, Ng Christopher, Shelby Anderson, John Daliva, Naji Muwanas, Igal Tarash, Cesar Ochoa, Airani Sathananthan, Vishwanath Venketaraman
BACKGROUND: According to the World Health Organization, as of 2014 9% of the world's adult population is affected by diabetes. Uncontrolled diabetes is a pro-inflammatory process that increases generation of reactive oxygen species (ROS). METHODS: The production of ROS leads to a chronic increase in oxidative stress which results in an increased susceptibility to infections. Individuals with type 2 diabetes mellitus (T2DM) are highly susceptible to Mycobacterium tuberculosis (M...
June 8, 2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27193030/lipid-based-vesicular-nanocargoes-as-nanotherapeutic-targets-for-the-effective-management-of-rheumatoid-arthritis
#5
Mahfoozur Rahman, Sarwar Beg, Gajanand Sharma, Sumant Saini, Rehan A Rub, Preeti Aneja, Firoz Anwar, Mohammad A Alam, Vikas Kumar
BACKGROUND: Rheumatoid arthritis (RA) is an immune mediated joint-based chronic inflammatory disorder recognized by joint inflammation, destruction, pain and remission. Currently, numerous pharmacotherapeutic strategies have gained immense popularity in RA therapy and improving the patient life. METHODS: Besides, it exhibits numerous drawbacks such as requirement of high dose of drugs, unavoidable adverse effects and diseases remission. Thus, use of currently available pharmacotherapeutics employing conventional formulations can only provide therapeutic effects to a certain extent...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27048277/hybolites-revisited
#6
Victor Norris, Cecile Verrier, Marc Feuilloley
BACKGROUND: Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis. METHODS: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling. RESULTS: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures as a determinant of the phenotype...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26844688/effect-of-low-dose-oral-vitamin-d-and-calcium-replacement-in-hiv-patients
#7
Satyajit Das, Shyamalie Bopitya, Ananya R Chowdhury, Archik Das, Huda Taha
BACKGROUND: There is high prevalence of vitamin-D deficiency and abnormal bone mineral density (BMD) in HIV patients. Our aim is to find out the effect of replacement of low dose oral vitamin-D (800 International unit) with calcium (500mg) as a once daily regimen along with antiretroviral (ARV) on serum vitamin-D and parathyroid hormone (PTH) level and bone mineral density (BMD) changes on patients with HIV infection who have vitamin- D deficiency. METHODS: This is a non-randomised, open label study...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26536892/the-antidiabetic-effects-of-the-bioactive-flavonoid-kaempferol-3-o-%C3%AE-d-6-p-coumaroyl-glucopyranoside-isolated-from-allium-cepa
#8
Ogbonna J Ikechukwu, Ofoefule S Ifeanyi
BACKGROUND: Allium cepa has been in use in traditional medicine in the treatment of diabetes mellitus. The aqueous and ethanolic extracts have been found effective in lowering blood glucose levels in experimental diabetic rats and guinea pigs. METHODS: The study was carried out to isolate the active principle responsible for the observed hypoglycaemic effect in experimental animals. Freeze-dried aqueous extract of Allium cepa was separated into various fractions using column chromatography with silica gel as a stationary phase...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26510900/effect-of-pistacia-atlantica-fruit-and-leaf-extracts-on-hydatid-cyst-protoscolices
#9
Mohammad Zibaei, Reza Rostamipour, Hassan Nayebzadeh
BACKGROUND: Treatment of human hydatidosis is mainly surgical, with chemical treatment being reserved as a coadjuvant treatment. Use of effective protoscolicidal agents during surgery of hydatid disease is essential to reduce the recurrence rate. OBJECTIVE: The aim of this study was to investigate the scolicidal effects of Pistacia atlantica leaf and fruit hydroalcoholic extracts on protoscolices of hydatid cyst. METHOD: Echinococcus granulosus protoscolices were obtained from 50 sheep infected with hydatid cysts...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26377799/site-targeted-press-coated-delivery-of-methylprednisolone-using-eudragit-rs-100-and-chitosan-for-treatment-of-colitis
#10
Swati Jagdale, Apoorva Chandekar
BACKGROUND: Inflammatory bowel disease (IBD) is one of the five most prevalent gastrointestinal disease burdens which commonly require lifetime care. Worldwide incidence rate of ulcerative colitis and Crohn's disease is about 16.8% and 13.4% respectively. Colitis is an inflammation of the colon. Colon targeted drug delivery will direct the drug to the colon. The drug will reach at the site of action and hence its side effects as well as dose can be reduced. Recent patent describes treatment of ulcerative colitis using anti CD3 antibodies, with nicotine and anti-depressant drugs, budesonide foam etc...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26310587/methicillin-resistant-staphylococcus-aureus-treatment-with-cultures-of-not-drug-resistant-staphylocuccus-epidermidis
#11
Felix-Martin Werner, Rafael Coveñas
The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, althouth in long-term care facilities these patients are not urgently isolated...
August 26, 2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/25876750/mers-cov-an-emerging-viral-zoonotic-disease-three-years-after-and-counting
#12
Ziad A Memish
No abstract text is available yet for this article.
April 15, 2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26497507/methicillin-resistant-staphylococcus-aureus-treatment-with-cultures-of-non-drug-resistant-staphylococcus-epidermidis
#13
Felix-Martin Werner, Rafael Covenas
The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, although in long-term care facilities these patients are not urgently isolated...
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26497506/in-vitro-antimicrobial-study-for-biological-evaluation-of-clerodendrum-infortunatum-linn
#14
Talukdar M Waliullah, Akter M Yeasmin, Ashraful Alam, Wahedul Islam, Parvez Hassan
OBJECTIVE: To explore a scientific idea, this study was examined for evaluation of antimicrobial potency using root, leaf and stem of ethyl acetate and chloroform extracts of C. infortunatum (Verbenaceae) due to randomly use in traditional medicine to cure common ailments such as intestinal disorder, diarrhea, tuberculosis and respiratory problems etc. METHODS: The in vitro application was carried out by using disc diffusion, micro broth dilution and serial dilution techniques against clinically important life threatening organisms...
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26365362/chloroquine-an-old-drug-with-new-perspective-against-giardiasis
#15
REVIEW
Angel A Escobedo, Pedro Almirall, Sérgio Cimerman, Marco Lalle, Frank Pacheco, Carlos Z Acanda, Niurka Sánchez
The occurrence of treatment failures to first-line treatment for giardiasis, one of the most widespread although neglected parasitic disease, has long been recognised. Nowadays, it starts to represent a great challenge to clinicians, especially in endemic countries. This requires the introduction of new drug interventions, but the development of novel drugs is a time and money consuming effort with most of the compounds never reaching the market. Consequently, alternative strategies are needed, especially for the treatment of giardiasis...
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26324233/antibiotic-susceptibility-patterns-of-extended-spectrum-beta-lactamase-and-non-extended-spectrum-beta-lactamase-pseudomonas-aeruginosa-clinical-isolates
#16
Mostafa Akbariqomi, Sobhan Ghafourian, Morovat Taherikalani, Satar Mohammadi, Iraj Pakzad, Nourkhoda Sadeghifard
BACKGROUND: Pseudomonas aeruginosa is known as an opportunistic pathogen responsible for nosocomial infections. Multidrug (MDR) resistance bacteria are considered as a worldwide issue. The current research goal to investigate the antibiotic susceptibility pattern in Extended Spectrum beta-lactamase and non Extended Spectrum beta-lactamase producing P. aeruginosa clinical isolates. METHODS: A total of 76 P.aeruginosa clinical isolates were collected from Milad hospital in Tehran, Iran, during 8 months period in 2012...
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26235217/a-novel-advanced-laboratory-diagnosis-to-guide-tuberculosis-drug-therapy
#17
Leonard Amaral, Dick van Soolingen
No abstract text is available yet for this article.
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26220069/optimal-antibiotic-dosage-for-chronic-kidney-disease-patient-a-pharmacological-manual-for-oral-clinicians
#18
Ramasamy Chidambaram
Chronic kidney disease, (CKD) a gradual and inevitable deterioration in renal function, is the disease with the most associations in dentistry. Dosage adjustment is one amongst the vital elements to be familiar with during their oral care. CKD patients take extended duration to filter out medications, therefore dosage must always be tailored under the supervision of nephrologist. The relished benefits from antibiotic could transform as anti-microbial resistance on their abuse and nephrotoxic when contraindicated drugs are encouraged...
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26203470/preface
#19
Dieter Kabelitz
No abstract text is available yet for this article.
2015: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/26100979/antiseptic-resistance-in-methicillin-sensitive-and-methicillin-resistant-staphylococcus-aureus-isolates-from-some-major-hospitals-iran
#20
Azar Hasanvand, Sobhan Ghafourian, Morovat Taherikalani, Farid A Jalilian, Nourkhoda Sadeghifard, Iraj Pakzad
BACKGROUND: Extensive use of antibiotics and biocide in treatment of patients and cleaning of surfaces and medical equipment has led to the emergence of resistant microorganisms. The current research goals to determine the antiseptics Minimum Inhibitory Concentration value in Staphylococcus aureus (methicillin -resistant Staphylococcus aureus and methicillin sensitive Staphylococcus aureus) isolates from some major hospitals in Iran and to detect qacA/B, norA , smr and blaZ genes. METHODS: Two hundred isolates of S...
2015: Recent Patents on Anti-infective Drug Discovery
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