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Recent Patents on Anti-cancer Drug Discovery

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https://www.readbyqxmd.com/read/27881057/recent-patents-on-heat-shock-proteins-targeting-antibodies
#1
João Fernandes, Pedro Alves
BACKGROUND: Heat shock proteins (Hsp) are major chaperone molecules that have recently emerged as cancer therapeutic targets owing to their involvement in tumor cell proliferation, differentiation, invasion and metastasis. High levels of extracellular Hsp90 and Hsp70 have been closely associated with a wide range of human cancers. Accumulating evidence suggests that the pharmacological inhibition of these molecules can play a pivotal role in non-surgical cancer treatment. Efforts have been taken to develop monoclonal antibodies (mAbs) and antibody fragments targeting extracellular Hsp90 and Hsp70, alone or conjugated with standard anticancer agents, to control several types of cancer, such as breast, colon, prostate or melanoma...
November 23, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27881056/recent-patents-on-proteasome-inhibitors-of-natural-origin
#2
Daniela Correia da Silva, Paula B Andrade, Vera Ribeiro, Patrícia Valentão, David Pereira
BACKGROUND: The proteasome is the major proteolytic site on the eukaryotic cell, degrading most of its short-lived or misfolded polypeptides. The ubiquitin-proteasome pathway has been found to play a fundamental role in the development of several pathologies, from cancer to neurodegenerative diseases, or even retroviral infections. Nature remains a powerful source for the discovery of bioactive compounds. Recently, a number of molecules of natural origin, as well as natural product derivatives, have been described as proteasome inhibitors...
November 23, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27809750/chaperoning-the-cancer-the-proteostatic-functions-of-the-heat-shock-proteins-in-cancer
#3
Sepideh Vahid, Daksh Thaper, Amina Zoubeidi
BACKGROUND: Protein homeostasis (proteostasis) is vital for the survival of cells in physiological and pathological conditions. Particularly, cancer cells are in constant state of cellular stress due to rapid proliferation and decreased quality control in proteosynthesis and therefore, are exceedingly dependent on the homeostasis pathways. Among the complex biological mechanisms regulating proteostasis are the highly conserved molecular chaperones, heat shock proteins (HSPs). HSPs assist cell survival by catalysing the proper folding of proteins, modulation of the apoptotic machinery and finally regulating the protein degradation machinery, providing either the stability or the degradation of selected proteins under stress conditions...
November 2, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27804867/medicinal-chemistry-insights-into-novel-hdac-inhibitors-an-updated-patent-review-2012-2016
#4
Peng Zhan, Xueshun Wang, Xinyong Liu, Takayoshi Suzuki
• Background: Many laboratories have made intensive efforts to develop potent, selective, and orally bioavailable HDAC inhibitors (HDACIs). Novel HDACIs are being developed with the objective of improving potency and selectivity against specific types of cancers or non-cancer diseases. • Objective: This updated patent review is an attempt to compile the work of various researchers of HDACIs from 2012 to mid 2016, and to enlighten and surprise both newcomers in this field and devoted medicinal chemists. • Method: According to the literature research and the writers' own research experience in the discovery of HDAC inhibitors...
November 1, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27784232/melissa-of%C3%AF-cinalis-and-vitamin-e-as-the-potential-therapeutic-candidates-for-reproductive-toxicity-caused-by-anti-cancer-drug-cisplatin-in-male-rats
#5
Maryam Iman, Mostafa Araghi, Toktam Heidari, Vahid Mohammadi
BACKGROUND: High doses of Cisplatin (CP) can disrupt the normal function of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia. OBJECTIVE: In this study, the defensive effect of Melissa officinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. METHOD: Thirty six male rats were distributed into 6 groups. Group 1 used as the negative control...
October 26, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27739356/contribution-of-latin-american-countries-to-cancer-research-and-patent-generation
#6
Martin Perez-Santos, Maricruz Anaya-Ruiz, Cindy Bandala
BACKGROUND: Data mining publications and patent data can provide decision support for scientists, inventors and industry in the field of cancer research. OBJECTIVE: The main objective of this article it to identify trends of research and patent generation productivity originating from Latin American countries in the field of cancer. METHOD: Publications were collected from the Scopus, Web of Science, PubMed database; and patents were collected from Latipat Espacenet databases...
October 13, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27697070/computational-approaches-for-translational-oncology-concepts-and-patents
#7
Marco Scianna, Luca Munaron
BACKGROUND: Cancer is a heterogeneous disease, which is based on an intricate network of processes at different spatiotemporal scales, from the genome to the tissue level. Hence the necessity for the biomedical and pharmaceutical research to work in a multiscale fashion. In this respect, a significant help derives from the collaboration with theoretical sciences. Indeed, mathematical models can provide insights into tumor-related processes and support clinical oncologists in the design of treatment regime, dosage, schedule and toxicity...
October 3, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27697069/kinase-inhibitor-indole-derivatives-as-anticancer-agents-a-patent-review
#8
Anuj Rathi, Riyaz Syed, Vijay Singh, Han-Seung Shin, Rahul V Patel
Cancer accounts for a numbers of deaths each year. Consequently, prevention of this deadly disease though the invention of new anticancer agents is of utmost importance. The current review elaborates the importance of indole designs as patented in the form of anticancer drug-like molecules targeting different cites of biological arena, specifically kinases such as platelet-derived growth factor receptor, vascular endothelial growth factor receptor and fibroblast growth factor receptor, Bruton's tyrosine kinase, anaplastic lymphoma kinase, Janus kinase, cyclin-dependent kinase aurora kinases A, B and C, checkpoint kinases, protein kinase R, Pim kinases, phosphoinositide 3-kinase, altered proteins kinases, polo-like kinase and many more...
October 3, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27670694/modeling-and-proposed-molecular-mechanism-of-hydroxyurea-through-docking-and-molecular-dynamic-simulation-to-curtail-the-action-of-ribonucleotide-reductase
#9
Maryam Iman, Zeynab Khansepid, Asghar Davood
BACKGROUND: Ribonucleotide Reductase (RNR) is an important anticancer chemotherapy target. It has main key role in DNA synthesis and cell growth. Therefore several RNR inhibitors, such as Hydroxyurea, have entered the clinical trials. Based on our proposed mechanism, radical site of RNR protein reacts with Hydroxyurea in which hydroxyurea is converted into its oxidized form compound III, and whereby the tyrosyl radical is converted into a normal tyrosine residue. OBJECTIVE: In this study, docking and molecular dynamics simulations were used for proposed molecular mechanism of Hydroxyurea in RNR inhibition as anticancer agent...
September 26, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27719653/licochalcone-b-arrests-cell-cycle-progression-and-induces-apoptosis-in-human-breast-cancer-mcf-7-cells
#10
Lina Yu, Jun Ma, Jichun Han, Bo Wang, Xiaoyu Chen, Caixia Gao, Defang Li, Qiusheng Zheng
BACKGROUND: Recently patent of Licochalcone B (LCB) as Anti-inflammatory agent has been developed. Emerging evidence showed that Licochalcone B (LCB) could be a promising alternative compound with anti-cancer activities. However, the anti-cancer mechanism of LCB in MCF-7 cells has not been fully investigated. OBJECTIVE: We aimed to unearth the anti-cancer effects and mechanism of LCB in breast cancer cells. METHOD: Cell proliferation and cell cycle were determined by sulforhodamine B assay and flow cytometry, respectively...
September 5, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27557814/mapping-the-technological-knowledge-landscape-the-case-of-epigenetics
#11
Chie Hoon Song, Janghyeok Yoon, Namuk Ko, Jeung-Whan Han
BACKGROUND: Epigenetics is a biomedical novelty in drug design and disease control whose mechanisms play a significant role in transferring environmental signals to determine patterns of gene expression. Systematic identification of the main trends in epigenetics patenting activity provides insights into fundamental building blocks of this research field and policy guidance to funding agencies. OBJECTIVE: The review aims at providing a comprehensive overview of the research and development trend in epigenetics by mapping the knowledge structure in patent landscape...
August 25, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27549139/episomal-lentiviral-vector-mediated-mir-145-overexpression-inhibits-proliferation-and-induces-apoptosis-of-human-esophageal-carcinoma-cells
#12
Junhe Zhang, Ailing Du, Li Wang, Xiaoyin Wang, Jian-Hui Gao, Tian-Yun Wang
BACKGROUND: Gene therapy is a promising approach for the treatment of various cancers. However, most viral vectors used for this purpose carry risks, including potential integration into the host genome. OBJECTIVE: We addressed this issue in the present study by constructing an episomal lentiviral vector using the β-interferon matrix attachment region to express the microRNA -145 (miR-145), and examining the effect of miR-145 overexpression on human esophageal carcinoma (EC) cells...
August 22, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27491402/egfr-and-eml4-alk-updated-therapies-in-non-small-cell-lung-cancer
#13
Ramon Andrade Bezerra De Mello, Davi Jing Jue Liu, Pedro N Aguiar, Hakaru Tadokoro
: Non-small cell lung cancer is the leading cancer-related cause of death. OBJECTIVE: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents. METHOD: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant...
August 2, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27480831/liposomal-irinotecan-in-the-treatment-of-refractory-pancreatic-cancer
#14
Minsig Choi, Harold Bien, Gerardo G Mackenzie
Effective therapies against metastatic pancreatic cancer remain limited, and despite treatment, many will ultimately progress. Previously, few options were available for second line therapy in metastatic pancreatic cancer. Liposomal encapsulated irinotecan, in combination with leucovorin-modulated fluorouracil, was found to significantly increase overall survival in patients who have progressed after gemcitabine-based therapy in a large, international, randomized clinical trial (NAPOLI-1). We reviewed the background of systemic therapy for metastatic pancreatic cancer, examined putative mechanisms for the success of encapsulated drugs, and identified recent patent applications on the use of liposomal irinotecan in pancreatic cancer...
July 28, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27450103/developing-antitumor-magnetic-hyperthermia-principles-materials-and-devices
#15
Alexander Tishin, Alexander A Shtil, Alexander P Pyatakov, Vladimir I Zverev
BACKGROUND AND OBJECTIVE: Methods of local or loco-regional anticancer treatment are of the utmost importance because the therapeutic 'power' is applied directly to the disease site. Consequently, general toxicity is minimized. Hyperthermia, that is, a sustained increase of intratumoral temperature up to 45 oC, has been investigated as a perspective treatment modality alone and/or in combination with ionizing radiation or chemotherapy. Still, the surrounding tissues can be damaged by the external heat...
July 19, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27450102/topoisomerase-i-and-ii-inhibitors-a-patent-review
#16
Kunal Nepali, Arshdeep Singh, Navdeep Kaur, Gurpreet Singh, Sahil Sharma, Pooja Sharma
BACKGROUND: Topoisomerases are a set of nuclear enzymes that have been established as one of the principal feature in handling of topological consequences of DNA during various genetic activities necessary for vitality of cell. Inhibition of these enzymes consequently leads to the blockage of ligation step of the cell cycle which generates single and double strand breakage in DNA strand. Introduction of these breaks subsequently leads to programmed cell death (Apoptosis). OBJECTIVE: In the past several years, topoisomerases have become one of the most expedient and strategic molecular targets for anticancer drugs and numerous patents have been filed and published on topoisomerase inhibitors...
July 19, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27855614/review-on-oxford-textbook-of-oncology-3rd-edition-2016
#17
Alexander A Shtil
No abstract text is available yet for this article.
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27855613/hoxb7-and-hsa-mir-222-as-the-potential-therapeutic-candidates-for-metastatic-colorectal-cancer
#18
Maryam Iman, Seyede Samaneh Mostafavi, Seyed Shahriar Arab, Sadegh Azimzadeh, Mansour Poorebrahim
BACKGROUND: Recent studies have shown that the high mortality of patients with colorectal cancer (CRC) is related to its ability to spread the surrounding tissues, thus there is a need for designing and developing new drugs. OBJECTIVE: Here, we proposed a combinational therapy strategy, an inhibitory peptide in combination with miRNA targeting, for modulating CRC metastasis. In this study, some of the recent patents were also reviewed. METHODS: After data analysis with GEO2R and gene annotation using DAVID server, regulatory interactions of differentially expressed genes (DEGs) were obtained from STRING, GeneMANIA, KEGG and TRED databases...
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27306881/epigenetics-in-medullary-thyroid-cancer-from-pathogenesis-to-targeted-therapy
#19
REVIEW
Giovanni Vitale, Alessandra Dicitore, Erika Messina, Concetta Sciammarella, Antongiulio Faggiano, Annamaria Colao
BACKGROUND: Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyroid gland. Mutations of the RET proto-oncogene are implicated in the pathogenesis of MTC. Germline activating mutations of this gene have been reported in about 88-98% of familial MTCs, while somatic mutations of RET gene have been detected in about 23-70% of sporadic forms. Although these genetic events are well characterized, much less is known about the role of epigenetic abnormalities in MTC...
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27194556/heteroaromatic-pim-kinase-inhibitors-containing-a-pyrazole-moiety
#20
REVIEW
Pascale Moreau, Fabrice Anizon, Francis Giraud, Yannick J Esvan
This review, of the literature published between 2010 and 2015 reports that molecules containing a non-fused and/or fused pyrazole moiety could exhibit very potent activity toward Pim kinases, including the inhibition of cellular Bad phosphorylation as well as antiproliferative activity against various cancer cells. Even if Pim kinase inhibitors currently in clinical trial do not exhibit a pyrazole moiety, heteroaromatic kinase inhibitors containing an indazole part such as Axitinib and Pazopanib already reached the market...
2016: Recent Patents on Anti-cancer Drug Discovery
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