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Radiation Oncology

M Oertel, S Scobioala, K Kroeger, A Baehr, L Stegger, U Haverkamp, M Schäfers, H-T Eich
BACKGROUND: Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was to provide insights in radiotherapy (RT)-treatment of recurrent PCA exhibiting ln- or osseous (oss)-oligometastases. METHODS: Between April 2012 and April 2017, 27 oligometastatic PCA patients (19 ln and 8 single oss) were treated with RT at our institution...
September 21, 2018: Radiation Oncology
Nicole Wiedenmann, Hatice Bunea, Hans C Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H Nicolay, Wolfgang A Weber, Michael Mix, Philipp T Meyer, Jürgen Hennig, Michael Bock, Anca L Grosu
Following the publication of this article [1], the authors noticed that figures 2, 3, 4 and 5 were in the incorrect order and thus had incorrect captions.
September 21, 2018: Radiation Oncology
Cheng-En Hsieh, Li-Yu Lee, Yung-Chih Chou, Kang-Hsing Fan, Ngan-Ming Tsang, Joseph Tung-Chieh Chang, Hung-Ming Wang, Shu-Hang Ng, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang, Chien-Yu Lin
BACKGROUND: The patterns of nodal relapse in submandibular gland carcinoma (SMGC) patients treated with postoperative radiotherapy (PORT) remain unclear. This study aims to investigate the nodal failure patterns and the utility of elective nodal irradiation (ENI) in SMGC patients undergoing PORT. METHODS: We retrospectively enrolled 65 SMGC patients who underwent PORT between 2000 and 2014. The nodal failure sites in relation to irradiation fields and pathological parameters were analyzed...
September 21, 2018: Radiation Oncology
Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, Robert Förster, Niccolò Giaj-Levra, Nikolaos Koutsouvelis, Aurelie Bertaut, Michel Zimmermann, Giuseppe Roberto D'Agostino, Filippo Alongi, Matthias Guckenberger, Raymond Miralbell
Following publication of the original article [1], the authors reported that one of the authors' names is spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original publication of this article has been corrected.
September 19, 2018: Radiation Oncology
Dong-Yun Kim, Il Han Kim, Sung-Soo Yoon, Hyoung Jin Kang, Hee Young Shin, Hyun-Cheol Kang
BACKGROUND: This study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transplantation. METHODS: The incidence of pulmonary toxicity (PT) and treatment efficacy were compared between the conventional (≥ 6 cGy/min) and reduced dose rate (< 6 cGy/min). Seventy-seven patients receiving once-daily TBI between 2000 and 2016 were reviewed...
September 18, 2018: Radiation Oncology
Xue Wang, Jin-Zhi Wang, Jian-Bin Li, Ying-Jie Zhang, Feng-Xiang Li, Wei Wang, Yan-Luan Guo, Qian Shao, Min Xu, Xi-Jun Liu, Yue Wang
BACKGROUND: Concurrent chemoradiotherapy is considered curative intent treatment for patients with non-operative esophageal cancer. Radiation-induced heart damage receives much attention. We performed repeated four-dimensional computed tomography (4DCT) to detect changes in cardiac volume during radiotherapy for esophageal cancer patients, and explored potential factors responsible for those changes. METHODS: Forty-six patients with esophageal cancer underwent enhanced 4DCT and three-dimensional (3D) CT scans before radiotherapy and every 10 fractions during treatment...
September 18, 2018: Radiation Oncology
Howard J Lee, Meghan W Macomber, Matthew B Spraker, Stephen R Bowen, Daniel S Hippe, Angela Fung, Kenneth J Russell, George E Laramore, Ramesh Rengan, Jay Liao, Smith Apisarnthanarax, Jing Zeng
BACKGROUND: We report prospectively captured clinical toxicity and patient reported outcomes in a single institutional cohort of patients treated for prostate cancer with proton beam therapy (PBT). This is the largest reported series of patients treated mostly with pencil beam scanning PBT. METHODS: We reviewed 231 patients treated on an IRB approved institutional registry from 2013 to 2016; final analysis included 192 patients with > 1-year of follow-up. Toxicity incidence was prospectively captured and scored using CTCAE v4...
September 17, 2018: Radiation Oncology
Narges Miri, Kimberley Legge, Kim Colyvas, Joerg Lehmann, Philip Vial, Alisha Moore, Monica Harris, Peter B Greer
BACKGROUND: A novel remote method for external dosimetric TPS-planned auditing of intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for clinical trials using electronic portal imaging device (EPID) has been developed. The audit has been applied to multiple centers across Australia and New Zealand. This work aims to assess the audit outcomes and explores the variables that contributed to the audit results. METHODS: Thirty audits were performed of 21 radiotherapy facilities, 17 facilities underwent IMRT audits and 13 underwent VMAT audits...
September 17, 2018: Radiation Oncology
Yanzhu Lin, Kai Chen, Zhiyuan Lu, Lei Zhao, Yalan Tao, Yi Ouyang, Xinping Cao
BACKGROUND: To compare the efficacies and toxicities of intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) or conventional two-dimensional radiotherapy (2D-RT) for definitive treatment of cervical cancer. METHODS: A meta-analysis was performed using search engines, including PubMed, Cochrane Library, Web of Science, and Elsevier. In the meta-analysis, odds ratios (ORs) were compared for overall survival (OS), disease-free survival (DFS), and acute and chronic toxicities...
September 14, 2018: Radiation Oncology
Jong Min Park, Jung-In Kim, So-Yeon Park, Do Hoon Oh, Sang-Tae Kim
BACKGROUND: We investigate the gamma passing rate (GPR) consistency when applying different types of gamma analyses, linacs, and dosimeters for volumetric modulated arc therapy (VMAT). METHODS: A total of 240 VMAT plans for various treatment sites, which were generated with Trilogy (140 plans) and TrueBeam STx (100 plans), were retrospectively selected. For each VMAT plan, planar dose distributions were measured with both MapCHECK2 and ArcCHECK dosimeters. During the planar dose distribution measurements, the actual multileaf collimator (MLC) positions, gantry angles, and delivered monitor units were recorded and compared to the values in the original VMAT plans to calculate mechanical errors...
September 14, 2018: Radiation Oncology
Jae Pil Chung, Young Min Seong, Tae Yeon Kim, Yona Choi, Tae Hoon Kim, Hyun Joon Choi, Chul Hee Min, Hamza Benmakhlouf, Kook Jin Chun, Hyun-Tai Chung
BACKGROUND: To measure the absorbed dose rate to water and penumbra of a Gamma Knife® (GK) using a polymethyl metacrylate (PMMA) phantom. METHODS: A multi-purpose PMMA phantom was developed to measure the absorbed dose rate to water and the dose distribution of a GK. The phantom consists of a hemispherical outer phantom, one exchangeable cylindrical chamber-hosting inner phantom, and two film-hosting inner phantoms. The radius of the phantom was determined considering the electron density of the PMMA such that it corresponds to 8 g/cm2 water depth, which is the reference depth of the absorbed dose measurement of GK...
September 14, 2018: Radiation Oncology
Sophie C Huijskens, Irma W E M van Dijk, Jorrit Visser, Brian V Balgobind, D Te Lindert, Coen R N Rasch, Tanja Alderliesten, Arjan Bel
BACKGROUND: Interfractional organ position variation might differ for abdominal organs and this could have consequences for defining safety margins. Therefore, the purpose of this study is to quantify interfractional position variations of abdominal organs in children in order to investigate possible correlations between abdominal organs and determine whether position variation is location-dependent. METHODS: For 20 children (2.2-17.8 years), we retrospectively analyzed 113 CBCTs acquired during the treatment course, which were registered to the reference CT to assess interfractional position variation of the liver, spleen, kidneys, and both diaphragm domes...
September 12, 2018: Radiation Oncology
Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Lucile Montagné, Daniel Lam Cham Kee, Jean Michel Hannoun-Lévi
BACKGROUND: To analyze the clinical outcome of elderly women with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interstitial high dose-rate brachytherapy (MIB). METHODS: A single institution retrospective cohort study was performed focusing on elderly patients (≥ 65 years old) presenting a low-risk breast carcinoma treated by lumpectomy plus axillary evaluation followed by MIB...
September 12, 2018: Radiation Oncology
J Krayenbuehl, M Zamburlini, S Ghandour, M Pachoud, S Lang-Tanadini, J Tol, M Guckenberger, W F A R Verbakel
BACKGROUND: Automated treatment planning and/or optimization systems (ATPS) are in the process of broad clinical implementation aiming at reducing inter-planner variability, reducing the planning time allocated for the optimization process and improving plan quality. Five different ATPS used clinically were evaluated for advanced head and neck cancer (HNC). METHODS: Three radiation oncology departments compared 5 different ATPS: 1) Automatic Interactive Optimizer (AIO) in combination with RapidArc (in-house developed and Varian Medical Systems); 2) Auto-Planning (AP) (Philips Radiation Oncology Systems); 3) RapidPlan version 13...
September 10, 2018: Radiation Oncology
Pierfrancesco Franco, Berardino De Bari, Francesca Arcadipane, Alexis Lepinoy, Manuela Ceccarelli, Gabriella Furfaro, Massimiliano Mistrangelo, Paola Cassoni, Martina Valgiusti, Alessandro Passardi, Andrea Casadei Gardini, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Andrea Evangelista, Umberto Ricardi, Gilles Créhange
BACKGROUND: To evaluate clinical outcomes of simultaneous integrated boost (SIB) - intensity modulated radiotherapy (RT) in patients with non metastatic anal cancer compared to those of a set of patients treated with 3-dimensional conformal RT and sequential boost (SeqB). METHODS: A retrospective cohort of 190 anal cancer patients treated at 3 academic centers with concurrent chemo-RT employing either SIB or SeqB was analysed. The SIB-group consisted of 87 patients, treated with 2 cycles of Mitomycin (MMC) and 5-Fluorouracil (5FU) using SIB-IMRT delivering 42-45Gy/28-30 fractions to the elective pelvic lymph nodes and 50...
September 10, 2018: Radiation Oncology
Liang Hong, Yun-Xia Huang, Qing-Yang Zhuang, Xue-Qing Zhang, Li-Rui Tang, Kai-Xin Du, Xiao-Yi Lin, Bu-Hong Zheng, Shao-Li Cai, Jun-Xin Wu, Jin-Luan Li
BACKGROUND: To investigate the treatment failure pattern and factors influencing locoregional recurrence of esophageal squamous cell carcinoma (ESCC) and examine patient survival with re-irradiation (re-RT) after primary radiotherapy. METHODS: We retrospectively analyzed 87 ESCC patients treated initially with radiotherapy. Failure patterns were classified into regional lymph node recurrence only (LN) and primary failure with/without regional lymph node recurrence (PF)...
September 10, 2018: Radiation Oncology
Hendrik Dapper, Markus Oechsner, Stefan Münch, Kai Borm, Jan Peeken, Michael Mayinger, Stephanie E Combs, Daniel Habermehl
BACKGROUND: The cranial border of the target volume (TV) in rectal cancer patients treated with neoadjuvant chemoradiation (nCRT) is mostly defined at the level of L5/S1. However, current studies have shown that relapse cranially of the target volume after neoadjuvant nCRT and surgery is very rare. A reduction of cranial TV margins could be reasonable to reduce toxicity to the organs at risk (OAR). In this study we compared the dose distribution to the OAR for different cranial longitudinal margins using a dose-volume histogram (DVH) analysis...
September 6, 2018: Radiation Oncology
Yvonne Dzierma, Katharina Mikulla, Patrick Richter, Katharina Bell, Patrick Melchior, Frank Nuesken, Christian Rübe
BACKGROUND: Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective of children with Morbus Hodgkin. METHODS: Eleven radiotherapy treatment plans from pediatric patients with Hodgkin's lymphoma were retrospectively analyzed, including imaging dose from scenarios using different energies (kV/MV) and planar/cone-beam computed tomography (CBCT) techniques...
September 5, 2018: Radiation Oncology
Jackson M May, Mark R Waddle, Daniel H Miller, William C Stross, Tasneem A Kaleem, Byron C May, Robert C Miller, Liuyan Jiang, Gerald W Strong, Daniel M Trifiletti, Kaisorn L Chaichana, Ronald Reimer, Han W Tun, Jennifer L Peterson
BACKGROUND: Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the central nervous system with treatment including surgery, radiotherapy, and chemotherapy. CASE PRESENTATION: Our patient was a 47 year old female presenting with progressive ataxia, headaches, imbalance, nausea, vomiting, and diplopia. MRI showed a heterogeneously enhancing lesion approximately 2...
September 5, 2018: Radiation Oncology
Dennis J Mohatt, Tianjun Ma, David B Wiant, Naveed M Islam, Jorge Gomez, Anurag K Singh, Harish K Malhotra
BACKGROUND: Stereotactic Body Radiotherapy (SBRT) is an ablative dose delivery technique which requires the highest levels of precision and accuracy. Modeling dose to a lung treatment volume has remained a complex and challenging endeavor due to target motion and the low density of the surrounding media. When coupled together, these factors give rise to pulmonary induced tissue heterogeneities which can lead to inaccuracies in dose computation. This investigation aims to determine which combination of imaging techniques and computational algorithms best compensates for time dependent lung target displacements...
September 4, 2018: Radiation Oncology
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