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Radiation Oncology

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https://www.readbyqxmd.com/read/27927235/stereoscopic-x-ray-imaging-cone-beam-ct-and-couch-positioning-in-stereotactic-radiotherapy-of-intracranial-tumors-preliminary-results-from-a-cross-modality-pilot-installation
#1
Barbara Zollner, Christian Heinz, Sabrina Pitzler, Farkhad Manapov, Steffi Kantz, Maya Christine Rottler, Maximilian Niyazi, Ute Ganswindt, Claus Belka, Hendrik Ballhausen
BACKGROUND: To assess the accuracy and precision of a fully integrated pilot installation of stereoscopic X-ray imaging and kV-CBCT for automatic couch positioning in stereotactic radiotherapy of intracranial tumors. Positioning errors as detected by stereoscopic X-ray imaging are compared to those by kV-CBCT (i.e. the accuracy of the new method is verified by the established method), and repeated X-ray images are compared (i.e. the precision of new method is determined intra-modally)...
December 7, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#2
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27887643/distribution-of-fdg-avid-nodes-in-esophageal-cancer-implications-for-radiotherapy-target-delineation
#3
Brandon Garcia, Karyn A Goodman, Lajhem Cambridge, Mark Dunphy, Abraham J Wu
PURPOSE: Clinical target volumes (CTV) for radiotherapy (RT) in esophageal cancer (EC) are based on standard expansions of primary tumor volume. Data is needed to define regions at highest risk for occult disease, based on histology and location of the primary tumor. We therefore reviewed PET scans in EC patients to characterize the location of FDG-avid lymph node metastases (LNM). MATERIALS AND METHODS: We identified 473 EC patients with reviewable pre-treatment PET-CT scans...
November 25, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27881187/class-solutions-for-sabr-vmat-for-high-risk-prostate-cancer-with-and-without-elective-nodal-irradiation
#4
Sarah O S Osman, Prakash Jeevanandam, Nithya Kanakavelu, Denise M Irvine, Ciara A Lyons, Suneil Jain, Alan R Hounsell, Conor K McGarry
BACKGROUND: The purpose of this study is to find the optimal planning settings for prostate SABR-VMAT for high-risk prostate cancer patients irradiated to prostate only (PO) or prostate and pelvic lymph nodes (PPLN). METHODS: For 10 patients, plans using 6MV flattened, flattening-filter-free (FFF) 6MV (6 F) and FFF 10MV (10 F) photon beams with full and partial arc arrangements were generated and compared. The prescribed dose was 40Gy to the prostate with 25Gy to the PLN in 5 fractions...
November 24, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27881158/evaluation-of-daily-patient-positioning-for-radiotherapy-with-a-commercial-3d-surface-imaging-system-catalyst%C3%A2
#5
F Walter, P Freislederer, C Belka, C Heinz, M Söhn, F Roeder
BACKGROUND: To report our initial clinical experience with the novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator for daily patient positioning in patients undergoing radiation therapy. METHODS: We retrospectively analyzed the patient positioning of 154 fractions in 25 patients applied to thoracic, abdominal, and pelvic body regions. Patients were routinely positioned based on skin marks, shifted to the calculated isocenter position and treated after correction via cone beam CT which served as gold standard...
November 24, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27876069/mgdg-extracted-from-spinach-enhances-the-cytotoxicity-of-radiation-in-pancreatic-cancer-cells
#6
Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara, Ryohei Sasaki
BACKGROUND: In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytotoxic effects of radiation in human pancreatic cancer cells in vitro and in vivo. METHODS: Glycoglycerolipids from spinach including MGDG were extracted from dried spinach. The cytotoxicity of MGDG were evaluated by the MTT assay using four human pancreatic cancer cell lines (MIAPaCa-2, AsPC-1, BxPC-3 and PANC-1) and normal human dermal fibroblasts (NHDFs)...
November 22, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27846916/intrafractional-dose-variation-and-beam-configuration-in-carbon-ion-radiotherapy-for-esophageal-cancer
#7
M F Haefner, F Sterzing, D Krug, S A Koerber, O Jaekel, J Debus, M M Haertig
BACKGROUND: In carbon ion radiotherapy (CIR) for esophageal cancer, organ and target motion is a major challenge for treatment planning due to potential range deviations. This study intends to analyze the impact of intrafractional variations on dosimetric parameters and to identify favourable settings for robust treatment plans. METHODS: We contoured esophageal boost volumes in different organ localizations for four patients and calculated CIR-plans with 13 different beam geometries on a free-breathing CT...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27846900/4dct-and-cbct-based-ptv-margin-in-stereotactic-body-radiotherapy-sbrt-of-non-small-cell-lung-tumor-adhered-to-chest-wall-or-diaphragm
#8
Yi Li, Jing-Lu Ma, Xin Chen, Feng-Wen Tang, Xiao-Zhi Zhang
BACKGROUND: Large tumor motion often leads to larger treatment volumes, especially the lung tumor located in lower lobe and adhered to chest wall or diaphragm. The purpose of this work is to investigate the impacts of planning target volume (PTV) margin on Stereotactic Body Radiotherapy (SBRT) in non-small cell lung cancer (NSCLC). METHODS: Subjects include 20 patients with the lung tumor located in lower lobe and adhered to chest wall or diaphragm who underwent SBRT...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27846899/contribution-of-submandibular-gland-and-swallowing-structure-sparing-to-post-radiation-therapy-peg-dependence-in-oropharynx-cancer-patients-treated-with-split-neck-imrt-technique
#9
Michael F Gensheimer, Matthew Nyflot, George E Laramore, Jay J Liao, Upendra Parvathaneni
BACKGROUND: Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of this study was to determine whether SMG sparing IMRT is associated with reduced post-treatment PEG dependence in locally advanced oropharynx cancer patients. METHODS: Patients treated with definitive radiation therapy for oropharynx cancer were included in this retrospective study...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27832799/estimation-of-second-cancer-risk-after-radiotherapy-for-rectal-cancer-comparison-of-3d-conformal-radiotherapy-and-volumetric-modulated-arc-therapy-using-different-high-dose-fractionation-schemes
#10
Daniel R Zwahlen, Laura I Bischoff, Günther Gruber, Marcin Sumila, Uwe Schneider
PURPOSE: To investigate second cancer risk (SCR) comparing volumetric modulated arc therapy (VMAT) and 3D conformal radiotherapy (3DCRT) with different high dose fractionation schemes. METHODS: VMAT and 3DCRT virtual treatment plans for 25 patients previously treated with radiotherapy for rectal cancer were evaluated retrospectively. Doses prescribed were 25 × 1.8 Gy and 5 × 5 Gy, respectively. SCR was estimated using a carcinogenesis model and epidemiological data for carcinoma and sarcoma induction...
November 10, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27829431/radiomics-based-targeted-radiotherapy-planning-rad-trap-a-computational-framework-for-prostate-cancer-treatment-planning-with-mri
#11
Rakesh Shiradkar, Tarun K Podder, Ahmad Algohary, Satish Viswanath, Rodney J Ellis, Anant Madabhushi
BACKGROUND: Radiomics or computer - extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomics along with deformable co-registration tools can be used to develop a framework to generate targeted focal radiotherapy treatment plans. METHODS: The Rad-TRaP framework comprises three distinct modules. Firstly, a module for radiomics based detection of PCa lesions on mpMRI via a feature enabled machine learning classifier...
November 10, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27825386/initial-results-for-patient-setup-verification-using-transperineal-ultrasound-and-cone-beam-ct-in-external-beam-radiation-therapy-of-prostate-cancer
#12
Anne Richter, Bülent Polat, Ingulf Lawrenz, Stefan Weick, Otto Sauer, Michael Flentje, Frederick Mantel
BACKGROUND: Evaluation of set up error detection by a transperineal ultrasound in comparison with a cone beam CT (CBCT) based system in external beam radiation therapy (EBRT) of prostate cancer. METHODS: Setup verification was performed with transperineal ultrasound (TPUS) and CBCT for 10 patients treated with EBRT for prostate cancer. In total, 150 ultrasound and CBCT scans were acquired in rapid succession and analyzed for setup errors. The deviation between setup errors of the two modalities was evaluated separately for each dimension...
November 8, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27821135/comparisons-of-volumetric-modulated-arc-therapy-vmat-quality-assurance-qa-systems-sensitivity-analysis-to-machine-errors
#13
Bin Liang, Bo Liu, Fugen Zhou, Fang-Fang Yin, Qiuwen Wu
BACKGROUND: In volumetric modulated arc therapy (VMAT), gantry angles, dose rate and the MLC positions vary with the radiation delivery. The quality assurance (QA) system should be able to catch the planning and machine errors. The aim of this study was to investigate the sensitivity of three VMAT QA systems to machine errors. METHODS: Several types of potential linac machine errors unique to VMAT delivery were simulated in sinusoidal function of gantry angle, including gantry angle itself, MLC position and linac output...
November 7, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27814726/absolute-volume-of-the-rectum-and-auc-from-rectal-dvh-between-25gy-and-50gy-predict-acute-gastrointestinal-toxicity-with-ig-imrt-in-prostate-cancer
#14
Céline Mirjolet, Paul M Walker, Mélanie Gauthier, Cécile Dalban, Suzanne Naudy, Frédéric Mazoyer, Etienne Martin, Philippe Maingon, Gilles Créhange
BACKGROUND: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC25-50). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC25-50 and the appearance of any acute GI toxicity...
November 4, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27799048/prostate-external-beam-radiotherapy-combined-with-high-dose-rate-brachytherapy-dose-volume-parameters-from-deformably-registered-plans-correlate-with-late-gastrointestinal-complications
#15
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
BACKGROUND: Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR) brachytherapy prostate treatment. METHODS: One hundred and eighteen patients received EBRT in 23 fractions of 2 Gy and HDR (TG43 algorithm) in 3 fractions of 6...
October 31, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27784326/treatment-planning-and-evaluation-of-gated-radiotherapy-in-left-sided-breast-cancer-patients-using-the-catalyst-tm-sentinel-tm-system-for-deep-inspiration-breath-hold-dibh
#16
S Schönecker, F Walter, P Freislederer, C Marisch, H Scheithauer, N Harbeck, S Corradini, C Belka
BACKGROUND: There is a potential for adverse cardiovascular effects in long-term breast cancer survivors following adjuvant radiotherapy (RT). For this purpose, the deep inspiration breath-hold technique (DIBH) has been introduced into clinical practice, to maximally reduce the radiation dose to the heart. However, there are a variety of DIBH delivery techniques, patient positioning and visual patient feedback mechanisms. The aim of the present study was to evaluate the application of radiotherapy in DIBH using the Catalyst(TM)/Sentinel(TM) system, with a special emphasis on treatment planning and dosimetric plan comparison in free breathing (FB) and DIBH...
October 26, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27782858/registration-uncertainties-between-3d-cone-beam-computed-tomography-and-different-reference-ct-datasets-in-lung-stereotactic-body-radiation-therapy
#17
Markus Oechsner, Barbara Chizzali, Michal Devecka, Stephanie Elisabeth Combs, Jan Jakob Wilkens, Marciana Nona Duma
BACKGROUND: The aim of this study was to analyze differences in couch shifts (setup errors) resulting from image registration of different CT datasets with free breathing cone beam CTs (FB-CBCT). As well automatic as manual image registrations were performed and registration results were correlated to tumor characteristics. METHODS: FB-CBCT image registration was performed for 49 patients with lung lesions using slow planning CT (PCT), average intensity projection (AIP), maximum intensity projection (MIP) and mid-ventilation CTs (MidV) as reference images...
October 26, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27770816/apparent-diffusion-coefficient-histogram-shape-analysis-for-monitoring-early-response-in-patients-with-advanced-cervical-cancers-undergoing-concurrent-chemo-radiotherapy
#18
Jie Meng, Lijing Zhu, Li Zhu, Huanhuan Wang, Song Liu, Jing Yan, Baorui Liu, Yue Guan, Yun Ge, Jian He, Zhengyang Zhou, Xiaofeng Yang
BACKGROUND: To explore the role of apparent diffusion coefficient (ADC) histogram shape related parameters in early assessment of treatment response during the concurrent chemo-radiotherapy (CCRT) course of advanced cervical cancers. METHODS: This prospective study was approved by the local ethics committee and informed consent was obtained from all patients. Thirty-two patients with advanced cervical squamous cell carcinomas underwent diffusion weighted magnetic resonance imaging (b values, 0 and 800 s/mm(2)) before CCRT, at the end of 2nd and 4th week during CCRT and immediately after CCRT completion...
October 22, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27769279/suspected-recurrence-of-brain-metastases-after-focused-high-dose-radiotherapy-can-18-f-fet-pet-overcome-diagnostic-uncertainties
#19
Alexander Romagna, Marcus Unterrainer, Christine Schmid-Tannwald, Matthias Brendel, Jörg-Christian Tonn, Silke Birgit Nachbichler, Alexander Muacevic, Peter Bartenstein, Friedrich-Wilhelm Kreth, Nathalie Lisa Albert
BACKGROUND: After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness of dynamic O-(2-(18)F-Fluoroethyl)-L-Tyrosine positron emission tomography ((18)F-FET PET) in patients with MRI-based suspicion of tumor recurrence after focused high dose radiotherapy of brain metastases. METHODS: Twenty-two patients with 34 brain metastases (median age 61...
October 21, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27769262/a-treatment-planning-study-of-proton-arc-therapy-for-para-aortic-lymph-node-tumors-dosimetric-evaluation-of-conventional-proton-therapy-proton-arc-therapy-and-intensity-modulated-radiotherapy
#20
Jeong-Eun Rah, Gwe-Ya Kim, Do Hoon Oh, Tae Hyun Kim, Jong Won Kim, Dae Yong Kim, Sung Yong Park, Dongho Shin
BACKGROUND: The purpose of this study is to evaluate the dosimetric benefits of a proton arc technique for treating tumors of the para-aortic lymph nodes (PALN). METHOD: In nine patients, a proton arc therapy (PAT) technique was compared with intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) techniques with respect to the planning target volume (PTV) and organs at risk (OAR). PTV coverage, conformity index (CI), homogeneity index (HI) and OAR doses were compared...
October 21, 2016: Radiation Oncology
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