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Radiation Oncology

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https://www.readbyqxmd.com/read/30016978/an-esophagus-sparing-technique-to-limit-radiation-esophagitis-in-locally-advanced-non-small-cell-lung-cancer-treated-by-simultaneous-integrated-boost-intensity-modulated-radiotherapy-and-concurrent-chemotherapy
#1
Li Ma, Bo Qiu, QiWen Li, Li Chen, Bin Wang, YongHong Hu, MengZhong Liu, Li Zhang, Yan Huang, XiaoWu Deng, YunFei Xia, MaoSheng Lin, Hui Liu
BACKGROUND: To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) and concurrent chemotherapy. METHODS: Eighty-seven patients with stage IIIA/B NSCLC who received definitive SIB-IMRT and concurrent chemotherapy had been divided into two groups: 1.with esophagus sparing technique; 2...
July 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30016964/rna-sequencing-in-non-small-cell-lung-cancer-shows-gene-downregulation-of-therapeutic-targets-in-tumor-tissue-compared-to-non-malignant-lung-tissue
#2
Kobe Reynders, Els Wauters, Matthieu Moisse, Herbert Decaluwé, Paul De Leyn, Stéphanie Peeters, Maarten Lambrecht, Kristiaan Nackaerts, Christophe Dooms, Wim Janssens, Johan Vansteenkiste, Diether Lambrechts, Dirk De Ruysscher
BACKGROUND: Gene expression of specific therapeutic targets in non-malignant lung tissue might play an important role in optimizing targeted therapies. This study aims to identify different expression patterns of fifteen genes important for targeted therapy in non-small cell lung cancer (NSCLC). METHODS: We prospectively collected tissue of NSCLC and non-malignant lung tissue from 25 primary resected patients. RNA-sequencing and 450 K methylation array profiling was applied to both NSCLC and non-malignant lung tissue and data were analyzed for 14 target genes...
July 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30012164/high-dose-rate-tandem-and-ovoid-brachytherapy-in-cervical-cancer-dosimetric-predictors-of-adverse-events
#3
Kara D Romano, Colin Hill, Daniel M Trifiletti, M Sean Peach, Bethany J Horton, Neil Shah, Dylan Campbell, Bruce Libby, Timothy N Showalter
BACKGROUND: Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended dose limits. However, recent reports suggest lower doses may be needed to avoid toxicity. The purpose of this study is to investigate incidence and predictive factors influencing gastrointestinal (GI) and genitourinary (GU) toxicity following HDR intracavitary brachytherapy for locally advanced cervical cancer...
July 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30012156/real-time-intra-fraction-motion-management-in-breast-cancer-radiotherapy-analysis-of-2028-treatment-sessions
#4
D Reitz, G Carl, S Schönecker, M Pazos, P Freislederer, M Niyazi, U Ganswindt, F Alongi, M Reiner, C Belka, S Corradini
BACKGROUND: Intra-fraction motion represents a crucial issue in the era of precise radiotherapy in several settings, including breast irradiation. To date, only few data exist on real-time measured intra-fraction motion in breast cancer patients. Continuous surface imaging using visible light offers the capability to monitor patient movements in three-dimensional space without any additional radiation exposure. The aim of the present study was to quantify the uncertainties of possible intra-fractional motion during breast radiotherapy...
July 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29996873/collimator-scatter-factor-monte-carlo-and-in-air-measurements-approaches
#5
A Fogliata, A Stravato, G Reggiori, S Tomatis, J Würfel, M Scorsetti, L Cozzi
BACKGROUND: Linac output as a function of field sizes has a phantom and a head scatter component. This last term can be measured in-air with appropriate build-up ensuring a complete electron equilibrium and the absence of the contaminant electrons. Equilibrium conditions could be achieved using a build-up cap or a mini-phantom. Monte Carlo simulations in a virtual phantom mimicking a mini-phantom were analysed with the aim of better understanding the setup conditions for measuring the collimator scatter factor that is the head scatter component of the linac output factors...
July 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29996863/feasibility-of-stereotactic-radiotherapy-for-lung-lesions-and-conventional-radiotherapy-for-nodal-areas-in-primary-lung-malignancies
#6
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Eun Kyung Choi
BACKGROUND: Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer. METHODS: This study included 21 patients with small primary lung tumors distant from the regional nodal areas. The SBRT dose was 40-60 Gy in 4 fractions. CRT doses were 66 Gy in 30 fractions for non-small cell lung cancer and 52.5 Gy in 25 fractions for small cell lung cancer...
July 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29980214/investigating-rectal-toxicity-associated-dosimetric-features-with-deformable-accumulated-rectal-surface-dose-maps-for-cervical-cancer-radiotherapy
#7
Jiawei Chen, Haibin Chen, Zichun Zhong, Zhuoyu Wang, Brian Hrycushko, Linghong Zhou, Steve Jiang, Kevin Albuquerque, Xuejun Gu, Xin Zhen
BACKGROUND: Better knowledge of the dose-toxicity relationship is essential for safe dose escalation to improve local control in cervical cancer radiotherapy. The conventional dose-toxicity model is based on the dose volume histogram, which is the parameter lacking spatial dose information. To overcome this limit, we explore a comprehensive rectal dose-toxicity model based on both dose volume histogram and dose map features for accurate radiation toxicity prediction. METHODS: Forty-two cervical cancer patients treated with combined external beam radiotherapy (EBRT) and brachytherapy (BT) were retrospectively studied, including 12 with Grade ≥ 2 rectum toxicity and 30 patients with Grade 0-1 toxicity (non-toxicity patients)...
July 6, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29973243/evaluation-of-a-new-predictor-of-heart-and-left-anterior-descending-artery-dose-in-patients-treated-with-adjuvant-radiotherapy-to-the-left-breast
#8
Lucas C Mendez, Alexander V Louie, Carolina Moreno, Matt Wronski, Andrew Warner, Eric Leung, Roberto Sakuraba, Juliana K Helito, Ana Rezende, Icaro T Carvalho, Eduardo Weltman
BACKGROUND: Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the need for breath-hold radiotherapy in left-sided breast cancer patients receiving adjuvant radiotherapy. METHODS: Fifty left-sided breast cancer patients treated with breast conserving surgery and adjuvant radiotherapy to the breast from a single institution were retrospectively studied...
July 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29970111/postoperative-chemo-radiation-in-patients-with-squamous-cell-cancers-of-the-head-and-neck-clinical-results-from-the-cohort-of-the-clinical-cooperation-group-personalized-radiotherapy-in-head-and-neck-cancer
#9
Cornelius Maihoefer, Lars Schüttrumpf, Corinna Macht, Ulrike Pflugradt, Julia Hess, Ludmila Schneider, Christine Woischke, Axel Walch, Philipp Baumeister, Thomas Kirchner, Horst Zitzelsberger, Claus Belka, Ute Ganswindt
BACKGROUND: Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer" focuses on the identification and validation of new biomarkers, which are aimed at eventually stratifying and personalizing the therapy concept. Hence, we reviewed all patients with head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx, treated with postoperative (chemo) radiation from 06/2008 until 06/2015 at the Department of Radiation Oncology in the University Hospital, LMU Munich...
July 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29970105/proton-versus-photon-deep-inspiration-breath-hold-technique-in-patients-with-hodgkin-lymphoma-and-mediastinal-radiation-a-planning-comparison-of-deep-inspiration-breath-hold-intensity-modulation-radiotherapy-and-intensity-modulated-proton-therapy
#10
Christian Baues, Simone Marnitz, Andreas Engert, Wolfgang Baus, Karolina Jablonska, Antonella Fogliata, Andrés Vásquez-Torres, Marta Scorsetti, Luca Cozzi
BACKGROUND: The benefits of proton therapy in the treatment of patients with Hodgkin lymphoma (HL) are controversially discussed. Therefore we compared intensitiy modulated proton therapy (IMPT) with intensity modulated radiotherapy (IMRT), in the form of volumetric modulated arc therapy (VMAT) in patients with Hodgkin lymphoma (HL), through a comparative treatment planning study. METHODS: Radiation plans for 21 patients with Hodgkin Lymphoma (HL) were computed for IMPT and deep inspiration breath hold (DIBH) VMAT...
July 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29945681/monte-carlo-verification-of-radiotherapy-treatments-with-cloudmc
#11
Hector Miras, Rubén Jiménez, Álvaro Perales, José Antonio Terrón, Alejandro Bertolet, Antonio Ortiz, José Macías
BACKGROUND: A new implementation has been made on CloudMC, a cloud-based platform presented in a previous work, in order to provide services for radiotherapy treatment verification by means of Monte Carlo in a fast, easy and economical way. A description of the architecture of the application and the new developments implemented is presented together with the results of the tests carried out to validate its performance. METHODS: CloudMC has been developed over Microsoft Azure cloud...
June 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29945636/monte-carlo-simulations-in-radiotherapy-dosimetry
#12
REVIEW
Pedro Andreo
BACKGROUND: The use of the Monte Carlo (MC) method in radiotherapy dosimetry has increased almost exponentially in the last decades. Its widespread use in the field has converted this computer simulation technique in a common tool for reference and treatment planning dosimetry calculations. METHODS: This work reviews the different MC calculations made on dosimetric quantities, like stopping-power ratios and perturbation correction factors required for reference ionization chamber dosimetry, as well as the fully realistic MC simulations currently available on clinical accelerators, detectors and patient treatment planning...
June 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29941049/significance-of-intra-fractional-motion-for-pancreatic-patients-treated-with-charged-particles
#13
Vania Batista, Daniel Richter, Naved Chaudhri, Patrick Naumann, Klaus Herfarth, Oliver Jäkel
BACKGROUND: Uncertainties associated with the delivery of treatment to moving organs might compromise the accuracy of treatment. This study explores the impact of intra-fractional anatomical changes in pancreatic patients treated with charged particles delivered using a scanning beam. The aim of this paper is to define the potential source of uncertainties, quantify their effect, and to define clinically feasible strategies to reduce them. METHODS: The study included 14 patients treated at our facility with charged particles (protons or 12C) using intensity modulated particle therapy (IMPT)...
June 25, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29941041/correction-to-retrospective-dosimetry-study-of-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma-measurement-guided-dose-reconstruction-and-analysis
#14
Wen-Zhao Sun, Dan-Dan Zhang, Ying-Lin Peng, Li Chen, De-Hua Kang, Bin Wang, Xiao-Wu Deng
The original version of this article [1] unfortunately contained a mistake.
June 25, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29941040/dose-constraints-in-the-rectum-and-bladder-following-carbon-ion-radiotherapy-for-uterus-carcinoma-a-retrospective-pooled-analysis
#15
Noriyuki Okonogi, Mai Fukahori, Masaru Wakatsuki, Yu Ohkubo, Shingo Kato, Yuhei Miyasaka, Hiroshi Tsuji, Takashi Nakano, Tadashi Kamada
BACKGROUND: Carbon-ion radiotherapy (C-ion RT) provides better dose distribution in cancer treatment compared to photons. Additionally, carbon-ion beams provide a higher biological effectiveness, and thus a higher tumor control probability. However, information regarding the dose constraints for organs at risk in C-ion RT is limited. This study aimed to determine the predictive factors for late morbidities in the rectum and bladder after carbon-ion C-ion RT for uterus carcinomas. METHODS: Between June 1995 and January 2010, 134 patients with uterus carcinomas were treated with C-ion RT with curative intent; prescription doses of 52...
June 25, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29940984/clinical-evaluation-of-intensity-modulated-radiotherapy-for-locally-advanced-pancreatic-cancer
#16
Yoko Goto, Akira Nakamura, Ryo Ashida, Katsuyuki Sakanaka, Satoshi Itasaka, Keiko Shibuya, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Toshihiko Masui, Yuzo Kodama, Kyoichi Takaori, Masahiro Hiraoka, Takashi Mizowaki
BACKGROUND: The purpose was to retrospectively evaluate the effect of intensity-modulated radiotherapy (IMRT) on gastrointestinal (GI) toxicities and outcomes compared to three-dimensional conformal radiotherapy (3DCRT) for locally advanced pancreatic cancer (LAPC). METHODS: We included 107 consecutive patients who underwent CRT for LAPC from September 2001 to March 2015; 80 patients underwent 3DCRT and 27 patients underwent IMRT. They were compared for GI toxicities, locoregional progression free survival (LRPFS), distant metastasis free survival (DMS), and overall survival (OS)...
June 25, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29929560/abdominal-dibh-reduces-the-cardiac-dose-even-further-a-prospective-analysis
#17
Feng Zhao, Jiayan Shen, Zhongjie Lu, Yongbiao Luo, Guorong Yao, Luyi Bu, Jia Ge, Xin Yang, Lihua Ning, Senxiang Yan
BACKGROUND: Deep inspiration breath hold (DIBH) can be performed using different breathing maneuvers, such as DIBH with a thoracic breathing maneuver (T-DIBH) and DIBH with an abdominal breathing maneuver (A-DIBH). Dosimetric benefits of A-DIBH were investigated in the treatment of left-sided breast cancer radiotherapy (RT) with both 3-Dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques. METHODS: Twenty-two patients with left-sided breast cancer were enrolled in this study...
June 22, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29925410/adjuvant-radiation-therapy-for-malignant-abrikossoff-s-tumor-a-case-report-about-a-femoral-triangle-localisation
#18
C Marchand Crety, C Garbar, G Madelis, F Guillemin, P Soibinet Oudot, J C Eymard, S Servagi Vernat
BACKGROUND: Granular cell or Abrikossoff's tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional. CASE PRESENTATION: We report a case of a 43-years-old patient who had a benign Abrikossoff's tumor localized in the right femoral triangle diagnosed at the biopsy. The patient underwent a surgical tumorectomy and inguinal lymph nodes resection. Histologically, the tumor showed enough criteria to give diagnosis of malignancy: nuclear pleomorphism, tumor cell spindling, vesicular nuclei with large nucleoli...
June 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29921291/urethra-sparing-stereotactic-body-radiotherapy-for-prostate-cancer-how-much-can-the-rectal-wall-dose-be-reduced-with-or-without-an-endorectal-balloon
#19
Angèle Dubouloz, Michel Rouzaud, Lev Tsvang, Wilko Verbakel, Mikko Björkqvist, Nadine Linthout, Joana Lencart, Juan María Pérez-Moreno, Zeynep Ozen, Lluís Escude, Thomas Zilli, Raymond Miralbell
BACKGROUND: This is a dosimetric comparative study intended to establish appropriate low-to-intermediate dose-constraints for the rectal wall (Rwall ) in the context of a randomized phase-II trial on urethra-sparing stereotactic body radiotherapy (SBRT) for prostate cancer. The effect of plan optimization on low-to-intermediate Rwall dose and the potential benefit of an endorectal balloon (ERB) are investigated. METHODS: Ten prostate cancer patients, simulated with and without an ERB, were planned to receive 36...
June 19, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29914515/clinical-trials-involving-positron-emission-tomography-and-prostate-cancer-an-analysis-of-the-clinicaltrials-gov-database
#20
Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis, Vikas Prasad, Stephanie Kroeze, Ivan Igrutinovic, Branislav Jeremic, Marcus Beck, Sebastian Zschaeck, Peter Wust, Pirus Ghadjar
BACKGROUND: The goal of this study is to evaluate the status and future perspectives of clinical trials on positron emission tomography in prostate cancer for diagnostic or therapeutic as well as for surveillance purposes. METHODS: The www.ClinicalTrials.gov database was searched on the 20th of January 2017 for all trials containing terms describing "prostate cancer" (prostate, prostatic, malignant, malignancy, cancer, tumor) and "positron emission tomography"...
June 18, 2018: Radiation Oncology
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