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Chinese Medicine

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https://www.readbyqxmd.com/read/27895702/ameliorating-effect-of-erxian-decoction-combined-with-fructus-schisandrae-chinensis-wu-wei-zi-on-menopausal-sweating-and-serum-hormone-profiles-in-a-rat-model
#1
Shi Wei Wang, Fei Hua Wu, Yan Bo Zhang, Liang Zhang, Jing Su, Hei Kei Wong, Ai Hua Liu, Ho Pan Cheung, Tzi Bun Ng, Yao Tong, Stephen Cho Wing Sze
BACKGROUND: Modified Erxian decoction (MEXD), i.e., Erxian decoction (EXD) with Fructus Schisandrae chinensis (Wu Wei Zi) added, has been used to alleviate menopausal symptoms. This study aimed to investigate the effects of MEXD on menopausal sweating and serum hormone levels in a rat model of menopause after oral administration of MEXD. METHODS: Quality control of MEXD was conducted by employing a reversed-phase high performance liquid chromatography column. The three treatment groups received oral administration of MEXD in 0...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27891174/combination-of-cisplatin-and-bromelain-exerts-synergistic-cytotoxic-effects-against-breast-cancer-cell-line-mda-mb-231-in-vitro
#2
Ahmad Zaim Mat Pauzi, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Abdul Rahman Omar, Suraini Abdul Aziz, Adam Leow Thean Chow, Tamilselvan Subramani, Soon Guan Tan, Noorjahan Banu Alitheen
BACKGROUND: Bromelain, which is a cysteine endopeptidase commonly found in pineapple stems, has been investigated as a potential anti-cancer agent for the treatment of breast cancer. However, information pertaining to the effects of combining bromelain with existing chemotherapeutic drugs remains scarce. This study aimed to investigate the possible synergistic cytotoxic effects of using bromelain in combination with cisplatin on MDA-MB-231 human breast cancer cells. METHOD: MDA-MB-231 cells were treated with different concentrations (0...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27733866/inhibitory-effect-of-trans-ferulic-acid-on-proliferation-and-migration-of-human-lung-cancer-cells-accompanied-with-increased-endogenous-reactive-oxygen-species-and-%C3%AE-catenin-instability
#3
Yao Fong, Chia-Chun Tang, Huei-Ting Hu, Hsin-Yu Fang, Bing-Hung Chen, Chang-Yi Wu, Shyng-Shiou Yuan, Hui-Min David Wang, Yen-Chun Chen, Yen-Ni Teng, Chien-Chih Chiu
BACKGROUND: Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains largely unknown. This study investigated the cellular physiological effects of trans-FA on the H1299 human lung cancer cell line. METHODS: The 2,2-diphenyl-1-picrylhydrazyl assay was used to determine free radical scavenging capability. Assessment of intracellular reactive oxygen species (ROS) was evaluated using oxidized 2',7'-dichlorofluorescin diacetate and dihydroethidium staining...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27708694/full-component-analysis-of-tianma-gouteng-yin
#4
Ying-Yu Huang, Liang-Feng Liu, Rui-Qi Yue, Jun Xu, Alan Ho, Min Li, Quan-Bin Han
BACKGROUND: Tianma-Gouteng-Yin (TGY), which is common Chinese medicine formulation consisting of 11 different herbs and being used in China for the treatment of Parkinson's disease, inflammatory conditions and cardiovascular diseases, was selected for full component analysis. The aim of this study was to quantitatively analyze the chemical profiles of ten commercial TGY samples and one sample produced in our laboratory. METHODS: Ultra-high performance liquid chromatography (UHPLC) coupled with quadrupole-tandem time-of-flight mass spectrometry (Q-TOF-MS) was used to analyze the non-saccharide small molecule components of the different TGY samples...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27708693/anti-cancer-effects-of-gynostemma-pentaphyllum-thunb-makino-jiaogulan
#5
Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie, Wenzhe Ma
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. In this review, we have summarized recent research progress on the anti-cancer activities and mechanisms of action of GpM, as well as determining the material basis for the anti-cancer effects of GpM by searching the PubMed, Web of Science and China National Knowledge Infrastructure databases...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27708692/in-silico-profiling-for-secondary-metabolites-from-lepidium-meyenii-maca-by-the-pharmacophore-and-ligand-shape-based-joint-approach
#6
Fan Yi, Xiao-Lei Tan, Xin Yan, Hai-Bo Liu
BACKGROUND: Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS: The pharmacophore-based PharmaDB targets database screening joint the ligand shape similarity-based WEGA validation approach is proposed to predict the targets of these unique constituents and was performed using Discovery Studio 4...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27708691/authentication-of-acori-tatarinowii-rhizoma-shi-chang-pu-and-its-adulterants-by-morphological-distinction-chemical-composition-and-its-sequencing
#7
Kelly Yin-Ching Lam, Chuen-Fai Ku, Huai-You Wang, Gallant Kar-Lun Chan, Ping Yao, Huang-Quan Lin, Tina Ting-Xia Dong, Hong-Jie Zhang, Karl Wah-Keung Tsim
BACKGROUND: Acori Tatarinowii Rhizoma (ATR; rhizome of Acorus tatarinowii Schott) (Shi Chang Pu) is widely used in Chinese medicine (CM) to resuscitate, calm the mind, resolve shi (dampness) and harmonize the wei (stomach). Seven different species have been identified as belonging to the genus Acorus, all of which can be found in China. However, it can be difficult to distinguish the different species of Acorus because of their morphological similarities. The aim of this study was to authenticate Acorus species using macroscopic and microscopic techniques, chemical analysis and DNA authentication and to compare the resolution power and reliability of these different methods...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27660650/adjunctive-use-of-modified-yunu-jian-in-the-non-surgical-treatment-of-male-smokers-with-chronic-periodontitis-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Kwan-Yat Zee, Pui Sze Chan, Johnson Chun Sing Ho, Stanley Man Lung Lai, Esmonde Francis Corbet, Wai Keung Leung
BACKGROUND: Yunu-Jian (YJ) is a Chinese medicine (CM) heat purging formula, which is used to reduce wei huo (stomach-heat, SH) and enrich shen yin (kidney-yin, KY). This formula is also commonly used to manage diabetes mellitus and gum/oral inflammation. The activity of YJ can be modified or refined by the addition of other CM herbs and/or minor changes to one of its five key ingredients. The aim of this study was to evaluate the adjunctive use of modified YJ (mYJ) or YJ containing additional osteoblast-stimulating and inflammation-modulating CM herbs in the non-surgical periodontal treatment of smokers with chronic periodontitis in a randomized, double-blind, prospective, placebo-controlled study...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27617027/chi-ju-di-huang-wan-protects-rats-against-retinal-ischemia-by-downregulating-matrix-metalloproteinase-9-and-inhibiting-p38-mitogen-activated-protein-kinase
#9
Hsiao-Ming Chao, Lei Hu, Ji-Min Cheng, Xiao-Qian Liu, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Xiu-Mei Zhang
BACKGROUND: Retinal ischemia is a retinal disorder related to retinal vascular occlusion, glaucoma, diabetic retinopathy and age-related macular degeneration. The study aimed to evaluate the protective effects and underlying mechanisms of Chi-Ju-Di-Huang-Wan (CJDHW) against retinal ischemia in rats. METHODS: High intraocular pressure (HIOP)-induced retinal ischemia was established in Wistar rats by raising their intraocular pressure to 120 mmHg for 60 min with in an eye whose anterior chamber was cannulated with a 30-guage needle adapted to a normal saline bottle through an intravenous line...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27582785/attenuation-of-blood-pressure-in-spontaneously-hypertensive-rats-by-acupuncture-was-associated-with-reduction-oxidative-stress-and-improvement-from-endothelial-dysfunction
#10
Sin Bond Leung, Hongwei Zhang, Chi Wai Lau, Zhi-Xiu Lin
BACKGROUND: Hypertension can be treated effectively by acupuncture; however, the association between acupuncture and endothelial function remains unknown. This study aimed to investigate the effects of acupuncture on endothelial dysfunction and oxidative stress-related parameters in spontaneously hypertensive animals. METHODS: Eighteen-week-old Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were arbitrarily divided into four groups: WKY control (n = 8), SHR control (n = 8), SHR sham-acupuncture (n = 8) and SHR acupuncture (n = 8)...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27478496/conservation-and-sustainable-use-of-medicinal-plants-problems-progress-and-prospects
#11
Shi-Lin Chen, Hua Yu, Hong-Mei Luo, Qiong Wu, Chun-Fang Li, André Steinmetz
Medicinal plants are globally valuable sources of herbal products, and they are disappearing at a high speed. This article reviews global trends, developments and prospects for the strategies and methodologies concerning the conservation and sustainable use of medicinal plant resources to provide a reliable reference for the conservation and sustainable use of medicinal plants. We emphasized that both conservation strategies (e.g. in situ and ex situ conservation and cultivation practices) and resource management (e...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27478495/phytochemicals-and-potential-health-effects-of-sambucus-williamsii-hance-jiegumu
#12
REVIEW
Hui-Hui Xiao, Yan Zhang, Raymond Cooper, Xin-Sheng Yao, Man-Sau Wong
Sambucus williamsii Hance (Jiegumu) is traditionally used in Chinese medicine to treat bone and joint diseases. The major phytochemicals in S. williamsii are lignans, terpenoids, and phenolic acids, together with trace amounts of essential oils, minerals, amino acids, and natural pigments. In this review, a database search for studies published from 1990 to November 2015 was conducted using PubMed, the China Academic Journals Full-Text Database, and Google Scholar with the keywords "Sambucus williamsii Hance", "Sambucus williamsii", "Sambucus williamsii + clinic", "Sambucus williamsii + biology", "Sambucus williamsii + chemicals", and "Jiegumu", which covered chemical studies, cell culture studies, animal experiments, and clinical studies...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27471547/evaluation-of-the-accuracy-of-diagnostic-scales-for-a-syndrome-in-chinese-medicine-in-the-absence-of-a-gold-standard
#13
Xiao Nan Wang, Vanessa Zhou, Qiang Liu, Ying Gao, Xiao-Hua Zhou
BACKGROUND: The concept of syndromes (zhengs) is unique to Chinese medicine (CM) and difficult to measure. Expert consensus is used as a gold standard to identify zhengs and evaluate the accuracy of existing diagnostic scales for zhengs. But, the use of expert consensus as a gold standard is problematic because the diagnosis of zhengs by expert consensus is not 100 % accurate. This study aimed to evaluate the accuracy of standardized diagnostic scales for a syndrome zhengs in the absence of a gold standard, with application to internal wind (nei feng) syndrome in ischemic stroke patients...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27453720/indication-of-nerve-growth-factor-binding-components-from-herbal-extracts-by-herbochip-a-platform-for-drug-screening-on-a-chip
#14
Pinky Sum Chi Lee, Laura Minglu Zhang, Artemis Lu Yan, Kelly Yin Ching Lam, Tina Tingxia Dong, Huangquan Lin, Gallant Kar Lun Chan, Karl Wah Keung Tsim
BACKGROUND: HerboChip is an array of different fractions deriving from herbal extracts. This study aimed to identify effective components from Chinese medicine (CM) that interact with nerve growth factor (NGF) as a target using HerboChip. METHODS: Fifty types of CM that are traditionally used as remedies for emotion imbalance were selected and extracted with 50 % ethanol. Biotinylated-NGF was hybridized with over 300 chips coated with different HPLC-separated fractions from CM extracts and straptavidin-Cy5 was used to identify the NGF-bound fractions...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27390588/assessing-the-quality-of-smilacis-glabrae-rhizoma-tufuling-by-colormetrics-and-uplc-q-tof-ms
#15
Xicheng He, Tao Yi, Yina Tang, Jun Xu, Jianye Zhang, Yazhou Zhang, Lisha Dong, Hubiao Chen
BACKGROUND: The quality of the materials used in Chinese medicine (CM) is generally assessed based on an analysis of their chemical components (e.g., chromatographic fingerprint analysis). However, there is a growing interest in the use of color metrics as an indicator of quality in CM. The aim of this study was to investigate the accuracy and feasibility of using color metrics and chemical fingerprint analysis to determine the quality of Smilacis Glabrae Rhizoma (Tufuling) (SGR). The SGR samples were divided into two categories based on their cross-sectional coloration, including red SGR (R-SGR) and white SGR (W-SGR)...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27385975/influence-of-sulfur-fumigation-on-glycoside-profile-in-platycodonis-radix-jiegeng
#16
Xiao-Qing Ma, Su-Mei Li, Chi Leung Chan, Tao Su, Wei-Dong Li, Hui Cao, Wang-Fun Fong, Zhi-Ling Yu
BACKGROUND: Over recent decades, sulfur fumigation is becoming abused in processing some freshly harvested herbs used as both medicine and food, although it has been questioned whether sulfur fumigation will change the efficacy and safety of the herbs. One of the herbs commonly processed by sulfur fumigation is Platycodonis Radix (Jiegeng in Chinese). Glycosides are the main bioactive components of Jiegeng. Up to the present, no study has been carried out to evaluate the impact of sulfur fumigation on glycoside profile of Jiegeng...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27375770/aikeqing-decreases-viral-loads-in-shiv89-6-infected-chinese-rhesus-macaques
#17
Gao-Hong Zhang, Jian-Bao Han, Lin Zhu, Rong-Hua Luo, Xi-He Zhang, Xin Chen, Ying-Jie Hu, Lin-Chun Fu, Yong-Tang Zheng
BACKGROUND: Aikeqing (AKQ) has been shown in clinical studies to improve quality of life of HIV/AIDS patients, but anti-HIV activity has not been determined. The SHIV-infected macaque is an important animal model for testing antiviral drugs. This study aimed to determine the anti-HIV activity of AKQ in chronically SHIV89.6-infected Chinese rhesus macaques. METHODS: Nine Chinese rhesus macaques were inoculated intravenously with SHIV89.6 virus. At 11 weeks post-infection, the animals were arbitrarily divided into three groups: high-dose (AKQ 1...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27375769/antioxidant-and-physiological-effects-of-si-wu-tang-on-skin-and-liver-a-randomized-double-blind-placebo-controlled-clinical-trial
#18
Hui-Fang Chiu, Ying-Hua Wu, You-Cheng Shen, Shing-Jung Wang, Kamesh Venkatakrishnan, Chin-Kun Wang
BACKGROUND: Si-Wu-Tang (SWT) is used to treat various gynecological disorders in Chinese medicine. This study investigated the antioxidant and physiological effects of SWT on the skin and liver in healthy adults. METHODS: This randomized, crossover, double-blind, placebo-controlled clinical trial was conducted at Chung Shan Medical University Hospital in December 2008. Participants with uncontrolled diabetes, heart disease, liver disease, kidney disease, cancer, and pregnancy were excluded...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27366203/synergistic-effects-of-melphalan-and-pinus-kesiya-royle-ex-gordon-simaosong-extracts-on-apoptosis-induction-in-human-cancer-cells
#19
Natthida Weerapreeyakul, Sasipawan Machana, Sahapat Barusrux
BACKGROUND: This study aims to determine the synergistic effects of the chemotherapeutic drug melphalan and the phytoconstituents extracted from Pinus kesiya Royle ex Gordon (Simaosong) in human cancer cells. METHODS: P. kesiya twigs extracted from 50 % ethanol-water were evaluated alone (6-500 µg/mL) and in combination with melphalan (0.75-15 µg/mL). The cytotoxic effects of single extract or extract and melphalan combination were examined by a neutral red assay to investigate their antiproliferative and apoptosis induction effects in the U937 and HepG2 cell lines...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27347002/chinese-herbal-medicine-for-constipation-zheng-based-associations-among-herbs-formulae-proprietary-medicines-and-herb-drug-interactions
#20
Linda L D Zhong, Guang Zheng, Li Da Ge, Cheng Yuan Lin, Tao Huang, Ling Zhao, Cheng Lu, Ai Ping Lu, Zhao Xiang Bian
BACKGROUND: As current symptomatic treatments of constipation are still unsatisfactory, an increasing number of patients seek help from Chinese medicine (CM), particularly Chinese herbal medicine (CHM). This study aimed to review the most frequently used CHM herbs and formulae, proprietary CHMs, and herb-drug interactions for functional constipation using zheng (syndrome)-based differentiation, and to determine the current practice of zheng-based CHM treatments for functional constipation...
2016: Chinese Medicine
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