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Chinese Medicine

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https://www.readbyqxmd.com/read/29743936/clarifying-the-origin-of-houzao
#1
Zhongzhen Zhao, Eric Brand, Hiu Yee Kwan, Quanbin Han, Mengjia Zhou
Background: Houzao (bezoar) is a valuable imported Chinese medicine that is commonly used as a pediatric medicine to transform phlegm. There are mainly two types of Houzao, "Southeast Asian Houzao" and "Indian Houzao". "Indian Houzao" is the dominant commercial product accounts for over 95% of the actual utilization in the market. However, its origin, formation, composition, efficacy and pharmacology remain unclear. Therefore, we have conducted on-site investigation to clarify the origin of Indian Houzao...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29743935/pharmacokinetics-of-chinese-medicines-strategies-and-perspectives
#2
REVIEW
Ru Yan, Ying Yang, Yijia Chen
The modernization and internationalization of Chinese medicines (CMs) are hampered by increasing concerns on the safety and the efficacy. Pharmacokinetic (PK) study is indispensable to establish concentration-activity/toxicity relationship and facilitate target identification and new drug discovery from CMs. To cope with tremendous challenges rooted from chemical complexity of CMs, the classic PK strategies have evolved rapidly from PK study focusing on marker/main drug components to PK-PD correlation study adopting metabolomics approaches to characterize associations between disposition of global drug-related components and host metabolic network shifts...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29713369/extrahepatic-cytochrome-p450s-play-an-insignificant-role-in-triptolide-induced-toxicity
#3
Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang, Jun Gu
Background: Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. However, triptolide also causes severe side effects, which are manifested as toxicities in multiple organs. The aim of this study was to analyze the role of extrahepatic cytochrome P450 enzymes in triptolide-induced toxicity. Methods: Xh-CL mouse model with normal liver, but low extrahepatic P450 expression levels was used in this study...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29713368/comparative-study-of-the-polyphenol-content-related-anti-inflammatory-and-antioxidant-activities-of-two-urera-aurantiaca-specimens-from-different-geographical-areas
#4
Carla Marrassini, Ignacio Peralta, Claudia Anesini
Background: Urera aurantiaca is an Argentinean species that has been traditionally used to treat symptoms of inflammation. The aim of this study was to determine and compare the anti-inflammatory and antioxidant effects of two specimens of Urera aurantiaca obtained in the provinces of Salta and Misiones, which are two different geographical areas of Argentina. Methods: The anti-inflammatory activity of the extracts was tested in LPS-stimulated macrophages through the DPPH radical scavenging activity, the SOD-like activity, the reducing power and the inhibition of lipid peroxidation...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29713367/wentong-decoction-cures-allergic-bronchial-asthma-by-regulating-the-apoptosis-imbalance-of-eos
#5
Yue Yan, Hai-Peng Bao, Chun-Lei Li, Qi Shi, Yan-Hua Kong, Ting Yao, You-Lin Li
Background: Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to observe the effect of Chinese medicine Wentong decoction (WTD) in EOS apoptosis in asthmatic rats. This work also explored the mechanism of WTD regulation in EOS apoptosis and provided a new target for clinical treatment of asthma. Methods: Asthmatic rats induced by ovalbumin were treated with WTD...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29692864/techniques-for-extraction-and-isolation-of-natural-products-a-comprehensive-review
#6
REVIEW
Qing-Wen Zhang, Li-Gen Lin, Wen-Cai Ye
Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development. The amounts of bioactive natural products in natural medicines are always fairly low. Today, it is very crucial to develop effective and selective methods for the extraction and isolation of those bioactive natural products. This paper intends to provide a comprehensive view of a variety of methods used in the extraction and isolation of natural products...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29686726/hplc-icp-ms-speciation-analysis-and-risk-assessment-of-arsenic-in-cordyceps-sinensis
#7
Tian-Tian Zuo, Yao-Lei Li, Hong-Yu Jin, Fei Gao, Qi Wang, Ya-Dan Wang, Shuang-Cheng Ma
Background: Cordyceps sinensis , one of the most valued traditional herbal medicines in China, contains high amount of arsenic. Considering the adverse health effects of arsenic, this is of particular concern. The aim of this study was to determine and analyze arsenic speciation in C. sinensis , and to measure the associated human health risks. Methods: We used microwave extraction and high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry to determine and analyze the arsenic content in C...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29651300/a-concise-classification-of-bencao-materia-medica
#8
REVIEW
Zhongzhen Zhao, Ping Guo, Eric Brand
Books that record the sources and applications of medicinal materials are commonly known as bencao ( materia medica ) in China. Bencao ( materia medica ) literature review is the very first step in the standard authentication procedure of Chinese medicinals. As an important part of China's cultural heritage, these various bencao ( materia medica ) texts represent centuries of accumulated wisdom in combating disease and preserving health. In this short review, bencao ( materia medica ) classics of China are broadly divided into three major categories in our routine practice: mainstream bencao ( materia medica ), thematic bencao ( materia medica ) and regional bencao ( materia medica )...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29599817/wenyang-huazhuo-tongluo-formula-inhibits-fibrosis-via-suppressing-wnt-%C3%AE-catenin-signaling-pathway-in-a-bleomycin-induced-systemic-sclerosis-mouse-model
#9
Qian Wang, Wenhua Zang, Li Han, Lei Yang, Songshan Ye, Jingfeng Ouyang, Chaoyun Zhang, Yuefeng Bi, Cuiyue Zhang, Hua Bian
Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. So far, no Western medicine treatment can completely inhibit or reverse the progress of SSc, while at the same time, our previous series of studies have shown that the treatment of SSc by the Wenyang Huazhuo Tongluo formula (WYHZTL), a Chinese herbal decoction, shows a delightful prospect. The aim of this study is to further investigate the mechanism of anti-fibrosis of WYHZTL formula in SSc mouse model...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29588654/psoriasis-therapy-by-chinese-medicine-and-modern-agents
#10
REVIEW
Shikang Meng, Zibei Lin, Yan Wang, Zhenping Wang, Ping Li, Ying Zheng
Psoriasis is a chronic, painful, disfiguring and non-contagious skin disease that has globally affected at least 200 million patients. In general, mild to moderate psoriasis patients will be treated by chemical drugs or Chinese medicine, while targeting systemic biological drugs have been successfully developed with good efficacy but high cost burden to patients with severe psoriasis. Since the underlying mechanisms of psoriasis are not well understood, in this review, psoriasis pathogenesis and clinical therapeutic principles by modern medicine and Chinese medicine are extensively described...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29588653/approaches-in-studying-the-pharmacology-of-chinese-medicine-formulas-bottom-up-top-down-and-meeting-in-the-middle
#11
REVIEW
Tao Huang, Linda L D Zhong, Chen-Yuan Lin, Ling Zhao, Zi-Wan Ning, Dong-Dong Hu, Man Zhang, Ke Tian, Chung-Wah Cheng, Zhao-Xiang Bian
Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and through which signaling pathway(s) they act to modify disease symptoms, are still difficult tasks for researchers, even when equipped with an arsenal of advanced modern technologies. Multiple approaches, including network pharmacology, pharmaco-genomics, -proteomics, and -metabolomics, have been developed to study the pharmacology of CM formulas...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29560022/paeoniflorin-exerts-neuroprotective-effects-by-modulating-the-m1-m2-subset-polarization-of-microglia-macrophages-in-the-hippocampal-ca1-region-of-vascular-dementia-rats-via-cannabinoid-receptor-2
#12
Xian-Qin Luo, Ao Li, Xue Yang, Xiao Xiao, Rong Hu, Tian-Wen Wang, Xiao-Yun Dou, Da-Jian Yang, Zhi Dong
Background: Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are involved in neuronal protection against inflammation-induced neuronal injury. Cannabinoids acting at cannabinoid receptor 2 (CB2 R) can decrease inflammation. Based on the identification of paeoniflorin (PF) as a CB2 R agonist, we investigated the neuroprotective and microglia/macrophages M1 to M2 polarization promoting effects of PF in a permanent four-vessel occlusion rat model...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29541156/coptidis-rhizoma-and-its-main-bioactive-components-recent-advances-in-chemical-investigation-quality-evaluation-and-pharmacological-activity
#13
REVIEW
Fan-Cheng Meng, Zheng-Feng Wu, Zhi-Qi Yin, Li-Gen Lin, Ruibing Wang, Qing-Wen Zhang
Background: Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment of various diseases including bacillary dysentery, typhoid, tuberculosis, epidemic cerebrospinal meningitis, empyrosis, pertussis, and other illnesses. Methods: A literature survey was conducted via SciFinder, ScieneDirect, PubMed, Springer, and Wiley databases...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29492098/development-of-models-for-classification-of-action-between-heat-clearing-herbs-and-blood-activating-stasis-resolving-herbs-based-on-theory-of-traditional-chinese-medicine
#14
Zhao Chen, Yanfeng Cao, Shuaibing He, Yanjiang Qiao
Background: Action (" gongxiao " in Chinese) of traditional Chinese medicine (TCM) is the high recapitulation for therapeutic and health-preserving effects under the guidance of TCM theory. TCM-defined herbal properties (" yaoxing " in Chinese) had been used in this research. TCM herbal property (TCM-HP) is the high generalization and summary for actions, both of which come from long-term effective clinical practice in two thousands of years in China. However, the specific relationship between TCM-HP and action of TCM is complex and unclear from a scientific perspective...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29483938/ginsenoside-g-rh2-synergizes-with-smi-4a-in-anti-melanoma-activity-through-autophagic-cell-death
#15
Da-Lun Lv, Lei Chen, Wei Ding, Wei Zhang, He-Li Wang, Shuai Wang, Wen-Bei Liu
Background: Melanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-melanoma capacity are still unknown. Therefore, we investigated the effects of SMI-4a and combined SMI-4a with G-Rh2 on the viability, apoptosis and autophagy of melanoma, and to preliminarily explore the underlying mechanism of SMI-4a and combined SMI-4a with G-Rh2 in inhibiting tumor growth...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449878/complete-chloroplast-genome-of-the-medicinal-plant-amomum-compactum-gene-organization-comparative-analysis-and-phylogenetic-relationships-within-zingiberales
#16
Ming-Li Wu, Qing Li, Jiang Xu, Xi-Wen Li
Background: Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction of this plant has been hindered by many plant diseases. However, the correlational molecular studies are relatively scarce. Methods: The total chloroplast (cp) DNA was extracted according to previous studies, and then sequenced by 454 GS FLX Titanium platform...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449877/internationalization-of-traditional-chinese-medicine-current-international-market-internationalization-challenges-and-prospective-suggestions
#17
REVIEW
Annie Xianghong Lin, Ging Chan, Yuanjia Hu, Defang Ouyang, Carolina Oi Lam Ung, Luwen Shi, Hao Hu
Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and mechanism, difficulty of quality control, low preparation level, registration/policy barriers, and shortage of intellectual property. To deal with these challenges, suggestions were given including: (1) product innovation of TCM (study the TCM by using the methods and means of western medicine; innovate the basic theory of TCM; develop TCM health product); (2) standard innovation of TCM; (3) building big data platform of Chinese medicine (big data platform of TCM preparation; big data platform on the quality of TCM)...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449876/authenticity-analyses-of-rhizoma-paridis-using-barcoding-coupled-with-high-resolution-melting-bar-hrm-analysis-to-control-its-quality-for-medicinal-plant-product
#18
Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang, Shi-Lin Chen
Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var . chinensis (Franch.) Hara are the two main sources of Chonglou under the monograph of Rhizoma Paridis in Chinese Pharmacopoeia. In the local marketplace, however, this medicine is prone to be accidentally contaminated, deliberately substituted or admixed with other species that are similar to Rhizoma Paridis in shape and color...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29445417/bioactive-polysaccharides-from-natural-resources-including-chinese-medicinal-herbs-on-tissue-repair
#19
REVIEW
Qiu Li, Yiming Niu, Panfei Xing, Chunming Wang
Background: Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug delivery vehicles. In the past few years, increasing studies have started to develop natural polysaccharides-based biomaterials for various applications in tissue engineering and regenerative medicine. Main body: We discuss in this article the emerging applications of natural polysaccharides-particularly those derived from Chinese medicine-for wound healing...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29434653/shuganyin-decoction-improves-the-intestinal-barrier-function-in-a-rat-model-of-irritable-bowel-syndrome-induced-by-water-avoidance-stress
#20
Lu Lu, Liang Yan, Jianye Yuan, Qing Ye, Jiang Lin
Background: To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress. Methods: Forty male Wistar rats were divided into control, water-avoidance stress (WAS) group, WAS plus Shuganyin decoction (SGD) group and WAS plus dicetel (Dicetel) group. IBS was induced in rats by subjecting them to water-avoidance stress for 7 days. On day 4 of the WAS protocol, the rats were treated for 7 consecutive days (days 4-11) with SGD, dicetel or a negative control (saline)...
2018: Chinese Medicine
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