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Chinese Medicine

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https://www.readbyqxmd.com/read/29321808/itraq-based-proteomic-analysis-to-identify-the-molecular-mechanism-of-zhibai-dihuang-granule-in-the-yin-deficiency-heat-syndrome-rats
#1
Chang-Ming Liu, Jing Chen, Su Yang, Ting-Ting Jiang, Zhong-Liang Chen, Hui-Hui Tu, Lian-Gen Mao, Yu-Ting Hu, Lin Gan, Zhong-Jie Li, Ji-Cheng Li
Background: Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explore the molecular mechanism of ZDG in YDH syndrome, and the processes of YDH syndrome prevention and treatment have been developed slowly. The present study was aimed to explore the therapeutic mechanism of ZDG on YDH syndrome. Methods: The YDH syndrome rats were induced by hot Chinese herbs, then treated by ZDG orally for 1 week...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29321807/different-modulation-of-panax-notoginseng-on-the-absorption-profiling-of-triptolide-and-tripterine-from-tripterygium-wilfordii-in-rat-intestine
#2
Yiqun Li, Huiting Cao, Mengzhu Liu, Benyong Zhang, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu, Qichun Zhang
Background: Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods: The absorption of triptolide, triptonide, wilforlide and tripterine from monomer, TW, TW-PN, TW-Caulis Sinomenii (TW-CS) and Qing-Luo Tong-Bi were analyzed in duodenum, jejunum, ileum and colon of rat via single-pass intestinal perfusion model...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29299052/advances-in-bio-active-constituents-pharmacology-and-clinical-applications-of-rhubarb
#3
REVIEW
Yu-Jie Cao, Zong-Jin Pu, Yu-Ping Tang, Juan Shen, Yan-Yan Chen, An Kang, Gui-Sheng Zhou, Jin-Ao Duan
Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorous way. The main chemical compositions of rhubarb include anthraquinones, anthrones, stilbenes, tannins, polysaccharides etc. These compositions show extensive pharmacological activities including regulating gastrointestinal, anticancer, antimicrobial, hepatoprotective, anti-inflammatory, protecting cardiovascular, cerebrovascular and so on...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29296119/metabolic-regulations-of-a-decoction-of-hedyotis-diffusa-in-acute-liver-injury-of-mouse-models
#4
Min Dai, Fenglin Wang, Zengcheng Zou, Gemin Xiao, Hongjie Chen, Hongzhi Yang
Background: Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown. Methods: We use the cytokines expression, levels of serum alanine transaminase and aspartate transaminase, survival and histological analysis to measure the effect of decoction of HD on acute severe hepatitis of mouse induced by LPS/GALN. Meanwhile, we utilize GC/MS-based metabolomics to characterize the variation of metabolomes...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29234461/discrimination-of-radix-polygoni-multiflori-from-different-geographical-areas-by-uplc-qtof-ms-combined-with-chemometrics
#5
Jin-Fa Tang, Wei-Xia Li, Fan Zhang, Yu-Hui Li, Ying-Jie Cao, Ya Zhao, Xue-Lin Li, Zhi-Jie Ma
Background: Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM samples, ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) combined with chemometrics (partial least squared discriminant analysis, PLS‑DA) method was applied in the present study. Methods: The chromatography, chemical composition and MS information of RPM samples from 18 geographical origins were acquired and profiled by UPLC-QTOF/MS...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29177004/active-fraction-hs7-from-taiwanofungus-camphoratus-inhibits-akt-mtor-erk-and-stat3-pathways-and-induces-cdk-inhibitors-in-cl1-0-human-lung-cancer-cells
#6
I-Chun Lai, Gi-Ming Lai, Jyh-Ming Chow, Hsin-Lun Lee, Chuan-Feng Yeh, Chi-Han Li, Jiann-Long Yan, Shuang-En Chuang, Jacqueline Whang-Peng, Kuan-Jen Bai, Chih-Jung Yao
Background: The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC, these pathways driven by mutant EGFR can be treated by the tyrosine kinase inhibitors (TKIs)-mediated targeted therapy. However, for the most NSCLC, more novel targeted agents are imperatively needed...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29093747/hepatoprotective-properties-of-penthorum-chinense-pursh-against-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#7
Meng Wang, Xiao-Jiao Zhang, Ruibing Feng, Yun Jiang, Da-Yong Zhang, Chengwei He, Peng Li, Jian-Bo Wan
Background: Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The aims of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl4)-induced acute liver injury in mice. Methods: C57BL/6 mice were orally administered an aqueous extract of PCP (5.15 and 10.3 g/kg BW) or silymarin (100 mg/kg) once daily for 1 week prior to CCl4 exposure...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29093746/chemical-characterization-of-wound-ointment-wo-and-its-effects-on-fracture-repair-a-rabbit-model
#8
Zhixue Ou, Qi Cheng, Yueping Chen, Tao Chen, Xiangbin Rong, Feipan Long, Xiaoyun Zhang, Qinghua Liang, Zhe Feng
Background: Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to explore the corresponding molecular mechanism in cytokine. Methods: The qualitative and quantitative analysis of WO was conducted by liquid chromatography-mass spectrometry (LC-MS). Fifty-four Zealand mature male rabbits were randomly divided into 3 groups: Control group, Yunnan Baiyao (YB) group and WO group...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29090015/effects-of-pretreatment-with-methanol-extract-of-peucedani-radix-on-transient-ischemic-brain-injury-in-mice
#9
So-Youn Jung, Kyoung-Min Kim, Suin Cho, Sehyun Lim, Chiyeon Lim, Young Kyun Kim
BACKGROUND: Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of Angelica decursiva, is a well-known remedy for damp and phlegm in Korean medicine and has also been shown to exert antioxidant and anti-inflammatory activities. This study was performed to investigate the mechanism underlying the anti-inflammatory effect of methanol extract of PR (PRex) on cerebral ischemic injury...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/29046711/effect-of-methanol-extract-of-salviae-miltiorrhizae-radix-in-high-fat-diet-induced-hyperlipidemic-mice
#10
Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim, Suin Cho
BACKGROUND: The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to have a bitter flavor, be slightly cold in nature, and exert therapeutic actions in the heart and liver meridians. Thus, SR has been used to control symptoms related to cardiovascular diseases. Hyperlipidemia is recognized as the main cause of cerebrovascular and heart diseases; consequently, therapeutic strategies for hyperlipidemia have been widely studied...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28943888/ten-years-of-exploration-a-new-journey-to-start-advancing-chinese-medicine-to-the-next-level
#11
EDITORIAL
Chunming Wang, Chin Kio Lei, Ruibing Wang, Jianbo Xiao, Yitao Wang
No abstract text is available yet for this article.
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28919923/revealing-topics-and-their-evolution-in-biomedical-literature-using-bio-dtm-a-case-study-of-ginseng
#12
Qian Chen, Ni Ai, Jie Liao, Xin Shao, Yufeng Liu, Xiaohui Fan
BACKGROUND: Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as an example, biological dynamic topic model (Bio-DTM) was proposed to conduct a retrospective study and interpret the temporal evolution of the research of ginseng. METHODS: The system of Bio-DTM mainly includes four components, documents pre-processing, bio-dictionary construction, dynamic topic models, topics analysis and visualization...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28919922/anti-tumor-effects-of-the-american-cockroach-periplaneta-americana
#13
REVIEW
Yanan Zhao, Ailin Yang, Pengfei Tu, Zhongdong Hu
Since the incidence of cancer has been on the rise due to increasing exposure to various carcinogenic factors in recent years, cancer has gradually become the first killer to the health of human beings. A growing attention has been paid to anti-cancer effects of traditional Chinese medicine (TCM) with low toxicity and good efficacy. As a kind of TCM, Periplaneta americana (P. americana) has a good effect on clinical application, and its anti-tumor effects has been increasingly well studied. In this review, the research progress on the anti-tumor effects of P...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28878815/efficacy-of-chinese-herbal-medicine-for-stroke-modifiable-risk-factors-a-systematic-review
#14
REVIEW
Wenbo Peng, Romy Lauche, Caleb Ferguson, Jane Frawley, Jon Adams, David Sibbritt
BACKGROUND: The vast majority of stroke burden is attributable to its modifiable risk factors. This paper aimed to systematically summarise the evidence of Chinese herbal medicine (CHM) interventions on stroke modifiable risk factors for stroke prevention. METHODS: A literature search was conducted via the MEDLINE, CINAHL/EBSCO, SCOPUS, and Cochrane Database from 1996 to 2016. Randomised controlled trials or cross-over studies were included. Risk of bias was assessed according to the Cochrane Risk of Bias tool...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28852418/danggui-buxue-tang-a-simple-chinese-formula-containing-astragali-radix-and-angelicae-sinensis-radix-stimulates-the-expressions-of-neurotrophic-factors-in-cultured-sh-sy5y-cells
#15
Amy G W Gong, Huai Y Wang, Tina T X Dong, Karl W K Tsim, Y Z Zheng
BACKGROUND: Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the "Blood" functions of menopausal women. In traditional Chinese medicine (TCM) theory, "Blood" has a strong relationship with brain activities. Previous studies supported that some ingredients of DBT possessed neuronal beneficial functions. Therefore, the neurotrophic function and the mechanistic action of DBT were systematically evaluated in cultured human neuroblastoma SH-SY5Y cells...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28835770/a-network-pharmacology-based-strategy-deciphers-the-underlying-molecular-mechanisms-of-qixuehe-capsule-in-the-treatment-of-menstrual-disorders
#16
Yanqiong Zhang, Xia Mao, Jing Su, Ya Geng, Rui Guo, Shihuan Tang, Junfang Li, Xuefeng Xiao, Haiyu Xu, Hongjun Yang
BACKGROUND: QiXueHe Capsule (QXHC) is a Chinese patent drug that is extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated. METHODS: A list of QXHC putative targets were predicted using MetaDrug. An interaction network using links between QXHC putative targets and the known therapeutic targets of menstrual disorders was constructed. QXHC candidate targets were also identified via calculating the topological feature values of nodes in the network...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28785304/temporal-divergence-of-changes-in-pain-and-pain-free-grip-strength-after-manual-acupuncture-or-electroacupuncture-an-experimental-study-in-people-with-lateral-epicondylalgia
#17
Jaewon Jeon, Erin Bussin, Alex Scott
BACKGROUND: The objective of this study was to examine, in individuals with lateral epicondylalgia (LE), the acute time course of acupuncture-induced hypoalgesia and change in pain-free grip strength (PFGS). METHODS: This was an experimental study, conducted at a single research center in Vancouver, BC. Twenty-one participants with unilateral LE lasting more than 6 weeks duration were enrolled. Participants received a single treatment of acupuncture (either electroacupuncture, 10-30 Hz, or manual acupuncture, assigned randomly)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28770000/cupping-therapy-versus-acupuncture-for-pain-related-conditions-a-systematic-review-of-randomized-controlled-trials-and-trial-sequential-analysis
#18
REVIEW
Ya-Jing Zhang, Hui-Juan Cao, Xin-Lin Li, Xiao-Ying Yang, Bao-Yong Lai, Guo-Yang Yang, Jian-Ping Liu
BACKGROUND: Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies. OBJECTIVES: To compare the beneficial effectiveness and safety between cupping therapy and acupuncture for pain-related conditions to provide evidence for clinical practice. METHODS: Protocol of this review was registered in PROSPERO (CRD42016050986)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28702078/anticancer-activities-and-mechanisms-of-heat-clearing-and-detoxicating-traditional-chinese-herbal-medicine
#19
REVIEW
Yulin Zhang, Yeer Liang, Chengwei He
In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-clearing and detoxicating (HCD) herbs are essential components of TCM formulas for cancer treatment. An increasing interest has been focused on the study of HCD herbs and accumulated evidences have shown that HCD herbs or HCD herbs-based formulas exhibited remarkable anticancer effects when used alone or combined with other therapeutic approaches...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28702077/a-research-on-syndrome-element-differentiation-based-on-phenomenology-and-mathematical-method
#20
Enliang Yan, Jialin Song, Chaonan Liu, Wenxue Hong
BACKGROUND: As an empirical medical system independent of conventional Western medicine (CWM), over thousands of years, traditional Chinese medicine (TCM) has established its own unique method of diagnosis and treatment. The perspective of holism and system in TCM is essentially different from the view of Reductionism in CWM. With the development of modern science and technology, the restriction of reductionism is more and more prominent, and researchers begin to pay more attention to holistic thinking in TCM...
2017: Chinese Medicine
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