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Chinese Medicine

Yan Yan, Chenhui Du, Zhenyu Li, Min Zhang, Jin Li, Jinping Jia, Aiping Li, Xuemei Qin, Qiang Song
Background: Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been reported, such as enhanced anti-ovarian cancer, antioxidative activity, and neuroprotective effects. Ge-Gen-Qin-Lian decoction (GQD), a classic TCM formula, has been used to treat type 2 diabetes mellitus in China. In this study, GQD was fermented with Saccharomyces cerevisiae , and the antidiabetic activities and overall chemical profiles of raw and fermented GQD (FGQD) were systematically compared...
2018: Chinese Medicine
Lan-Ying Liu, Hong-Jian Zhang, Li-Yuan Luo, Jin-Bao Pu, Wei-Qing Liang, Chun-Qin Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang, Zhang-Jin Zhang
Background: Major depressive disorder (MDD) is a highly heterogeneous disease. Further classification may characterize its heterogeneity. The purpose of this study was to examine whether metabolomic variables could differentiate traditional Chinese medicine (TCM) diagnostic subtypes of MDD. Methods: Fifty medication-free patients who were experiencing a recurrent depressive episode were classified into Liver Qi Stagnation (LQS, n = 30) and Heart and Spleen Deficiency (HSD, n = 20) subtypes according to TCM diagnosis...
2018: Chinese Medicine
Ai-Ren Zuo, Huan-Huan Dong, Yan-Ying Yu, Qing-Long Shu, Li-Xiang Zheng, Xiong-Ying Yu, Shu-Wen Cao
Background: Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity. Phenolic hydroxyl is indispensable to the antioxidant activity of flavonoids. Isoeugenol, shikonin, baicalein, rosmarinic acid, and dihydromyricetin have respectively one, two, three, four, or five phenolic hydroxyls...
2018: Chinese Medicine
Alamgeer, Amber Sharif, Hira Asif, Waqas Younis, Humayun Riaz, Ishfaq Ali Bukhari, Asaad Mohamed Assiri
Ethno-pharmacological relevance: Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fundamental knowledge on various dermatological properties of medicinal plants of Pakistan and is aimed to provide a baseline for the discovery of new plants having activities against skin issues. Material and method: A total of 244 published articles were studied using different research engines like PubMed, Google, Google-scholar and science direct...
2018: Chinese Medicine
Jiatong Li, Jianfan Zhu, Hao Hu, Joanna E Harnett, Chi Ieong Lei, Ka Yin Chau, Ging Chan, Carolina Oi Lam Ung
Internationalization of Traditional/Complementary Medicine (T&CM) products is important for initiating and sustaining developments in this field. Particularly for traditional Chinese medicines (TCMs), the global market continues to expand due to an interest in the potential clinical benefits of traditional approaches that are largely considered lower risk and lower cost than many conventional treatments. While the benefits of internationalization hold clear advantages for the business of T&CM products, keeping abreast of regulatory processes in different countries and regions that regularly revise market entry requirements is challenging...
2018: Chinese Medicine
Fuhuan Fei, Huanmei Sun, Xixi Cheng, Jiajun Liu, Jing Wang, Qian Li, Yajun Zhang
Background: San-ao decoction (SAD) has been widely used in Chinese medicine against respiratory diseases, such as asthma and rhinallergosis. The bioactive compounds for such pharmacological action remain unknown. Methods: We developed a methodology to isolate the bioactive compounds of SAD. The assay involved the immobilization of beta 2-adrenoceptor ( β 2 -AR) onto magnetic fine particles, the capture of target compounds by the immobilized receptor, the identification of the receptor bound compounds by reversed-phase high-performance liquid chromatography coupled with tandem mass spectrometry...
2018: Chinese Medicine
Alamgeer, Waqas Younis, Hira Asif, Amber Sharif, Humayun Riaz, Ishfaq Ali Bukhari, Asaad Mohamed Assiri
Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous plant resources to cure various respiratory disorders. The primary objective of this review was to assemble all available ethno-medicinal data of plants used for respiratory disorders in Pakistan. Pharmacological activity of these plants (based upon published scientific research), distribution, diversity, use, preparation methods, economical value, conservation status and various available herbal products of some plants have also been explored...
2018: Chinese Medicine
Yuan Wei, Linwei Wang, Dujun Wang, Dan Wang, Chongwei Wen, Bangxin Han, Zhen Ouyang
Background: Polysaccharides are carbohydrate chains composed of linked monosaccharide units. Accumulating studies report that polysaccharides isolated from Dendrobium officinale have a variety of functions. However, the composition and anti-tumor activity of D. officinale grown in the Huoshan area are largely unknown. Methods: A polysaccharide (DOPA-1) was isolated from D. officinale by hot water extraction and ethanol precipitation, followed by purification via DEAE-cellulose and Sephadex G-100 chromatography...
2018: Chinese Medicine
Lihong Liu, Bo Du, Haiying Zhang, Xiaofei Guo, Zheng Zhou, Aihui Xiu, Chang Liu, Shiyu Su, Hao Ai
Background: Polycystic ovary syndrome (PCOS) significantly affects women's health and well-being. To explore the pharmacological basis of the Erxian decoction (EXD) action in PCOS therapy, a network interaction analysis was conducted at the molecular level. Methods: The active elements of EXD were identified according to the oral bioavailability and drug-likeness filters from three databases: traditional Chinese medicine system pharmacology analysis platform, TCM@taiwan and TCMID, and their potential targets were also identified...
2018: Chinese Medicine
Wei Shen, Hui Luo, Liangliang Xu, Zhifang Wu, Hongtai Chen, Yamei Liu, Lijuan Yu, Liuchao Hu, Bin Wang, Yiwen Luo
Background: Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway. Methods: BHD was extracted by petroleum, and its composition was analysed. Cell viability in the presence of various concentrations of BHD for 24, 48 and 72 h was measured using a Cell Counting Kit-8 assay...
2018: Chinese Medicine
Zhangfeng Zhong, Haibing Yu, Shengpeng Wang, Yitao Wang, Liao Cui
Background: Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese medicine may shed light on design of new therapeutic modes to overcome chemo-resistance. Although Rhizoma Curcumae possesses anti-cancer activities in various types of cancers, the effects and underlying mechanisms of its bioactive components against chemo-resistance are not clear...
2018: Chinese Medicine
Mengmeng Sun, Wen-Te Chang, Eduard Van Wijk, Min He, Roeland Van Wijk, Mei Wang
Background: Based on the principle of tradition Chinese medicine, the processing refers to various techniques that alter the overall properties of herbal materials to meet the requirements of therapeutic applications. However, the standards of quality control and scientific standard operation protocol for processing manufacturing are largely unknown and there is a huge demand for the development of scientific tools for evaluating the quality during and after the processing. The key challenge in evidence-based medicine is to characterize the processing of herbal materials from system-based perspective...
2018: Chinese Medicine
Ying-Jie Fu, Yu-Qi Yan, Hong-Qiong Qin, Sha Wu, Shan-Shan Shi, Xiao Zheng, Peng-Cheng Wang, Xiao-Yin Chen, Xiao-Long Tang, Zhen-You Jiang
Background: Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR7 (Toll-like receptor) initiates corresponding immune responses. Traditional Chinese Medicines (TCMs), including Yinqiao powder, Xinjiaxiangruyin and Guizhi-and-Mahuang decoction, have been extensively applied in clinical treatment of influenza. Although the therapeutic efficacy of TCMs against influenza virus in vivo was reported previously, its underlying mechanisms are not clearly understood...
2018: Chinese Medicine
Linlin Dong, Ruiyang Cheng, Lina Xiao, Fugang Wei, Guangfei Wei, Jiang Xu, Yong Wang, Xiaotong Guo, Zhongjian Chen, Shilin Chen
Background: Bacterial endophytes are widespread inhabitants inside plant tissues that play crucial roles in plant growth and biotransformation. This study aimed to offer information for the exploitation of endophytes by analyzing the bacterial endophytes in different parts of Panax notoginseng . Methods: We used high-throughput sequencing methods to analyze the diversity and composition of bacterial endophytes from different parts of P. notoginseng . Results: A total of 174,761 classified sequences were obtained from the analysis of 16S ribosomal RNA in different parts of P...
2018: Chinese Medicine
Li Zhou, Sheng Wang, Qingxiu Hao, Liping Kang, Chuanzhi Kang, Jian Yang, Wanzhen Yang, Jingyi Jiang, Lu-Qi Huang, Lanping Guo
Background: Cordyceps sinensis ( C. sinensis ) is a famous and precious Traditional Chinese Medicine (TCM), while frequent reports of heavy metals, especially arsenic, exceeding standards in C. sinensis in recent years have raised concerns of its safety. Therefore, it is urgent for a research on heavy metals (Cu, Pb, As, Cd, Hg) in C. sinensis , of its bioaccessibility, dietary exposure estimation, arsenic speciation analysis and health risks assessment to human body. Methods: Three 30 g batches of mixed wild growth C...
2018: Chinese Medicine
Aleksandra Tarasiuk, Paula Mosińska, Jakub Fichna
Background: Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurvedic supplements and is believed to have a beneficial effect on the entire gastrointestinal (GI) tract. Purpose: We aim to summarize available literature focused on the components of TLP ( Terminalia chebula , Terminalia bellerica and Phyllanthus emblica ) and discusse their effectiveness and therapeutic value for improving lower GI symptoms in functional GI disorders, particularly irritable bowel syndrome (IBS)...
2018: Chinese Medicine
Ling Yuan, Lv Zhu, Yumei Zhang, Huan Chen, Hongxin Kang, Juan Li, Xianlin Zhao, Meihua Wan, Yifan Miao, Wenfu Tang
Background: The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including those of the liver and lungs. However, the pharmacological effects in the kidney, a target organ, are still unclear. This study aimed to investigate the herbal tissue pharmacology of DCQD for acute kidney injury (AKI) in rats with severe acute pancreatitis (SAP). Methods: Rats were randomly divided into the sham-operation group (SG), the model group (MG) and the low-, medium- and high-dose treatment groups (LDG, MDG, and HDG, respectively)...
2018: Chinese Medicine
Wei Sang, Zhangfeng Zhong, Kegang Linghu, Wei Xiong, Anfernee Kai Wing Tse, Wai San Cheang, Hua Yu, Yitao Wang
Background: Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory effects of SP were associated with the toll-like receptors (TLRs)-mediated nuclear factor-κB (NF-κB) and the mitogen-activated protein kinase (MAPK) signaling pathways. Methods: Raw 264.7 macrophages were pretreated with the 50% ethanol extract of SP (SPE, 50-200 µg/mL) and then co-treated with Pam3 CSK4 (200 ng/mL) for another 12 h...
2018: Chinese Medicine
Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang, Xianming Fan
Background: Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects. Recently, combination of two Chinese herbal medicine preparations, Salvia miltiorrhiza and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China...
2018: Chinese Medicine
Mu-Yang Huang, Le-Le Zhang, Jian Ding, Jin-Jian Lu
Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as targeted therapy and immunotherapy. Chinese medicinal herbs have attracted considerable attention due to their potential anticancer effects. Some natural products or formulae from Chinese medicinal herbs with directly or indirectly anticancer effects have been reported. In this article, we summarized the current progression on development of anticancer drugs from Chinese medicinal herbs, toward providing ideas for further development and application of Chinese medicinal herbs in cancer therapy...
2018: Chinese Medicine
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