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Simone Vargas da Silva, Mariana Renovato-Martins, Cristiane Ribeiro-Pereira, Marta Citelli, Christina Barja-Fidalgo
OBJECTIVE: To investigate the role of obesity on the bone marrow microenvironment and evaluate its possible impact on the adipogenic potential of mesenchymal stem cells (MSC). METHODS: C57BL/6 male mice were fed with a high-fat diet (HFD) for 10 weeks. Femurs and tibiae were collected, and bone marrow mesenchymal stem cells (BM-MSC) were isolated and analyzed for proliferative potential, immunophenotype, and expression of adipogenesis markers. Their capacity to produce extracellular matrix proteins and proinflammatory cytokines in vitro was also evaluated...
October 18, 2016: Obesity
Johnathan Watkins, Wahyu Wulaningsih
No abstract text is available yet for this article.
October 18, 2016: Obesity
Georgeta D Vaidean, Marta Manczuk, Jared W Magnani
OBJECTIVE: Obesity and hypertension often coexist and represent risk factors for atrial fibrillation. This study hypothesized that their single and joint effects on atrial remodeling would be reflected in the PR interval and P-wave durations on electrocardiogram (ECG). METHODS: This cross-sectional analysis of a community-based study included 11,308 men and women age 45-64. Atrial indices were obtained from digital standard 12-lead resting ECG. Analyses were adjusted for traditional cardiovascular risk factors...
October 18, 2016: Obesity
Meg H Zeller, Sanita Hunsaker, Carmen Mikhail, Jennifer Reiter-Purtill, Mary Beth McCullough, Beth Garland, Heather Austin, Gia Washington, Amy Baughcum, Dana Rofey, Kevin Smith
OBJECTIVE: To comprehensively assess family characteristics of adolescents with severe obesity and whether family factors impact weight loss outcomes following weight loss surgery (WLS). METHODS: Multisite prospective data from 138 adolescents undergoing WLS and primary caregivers (adolescent: Mage  = 16.9; MBMI = 51.5 kg/m(2) ; caregiver: Mage  = 44.5; 93% female) and 83 nonsurgical comparators (NSComp: adolescent: Mage  = 16.1; MBMI = 46.9 kg/m(2) ; caregiver: Mage  = 43...
October 18, 2016: Obesity
Sarah E Jackson, Clemens Kirschbaum, Andrew Steptoe
OBJECTIVE: There is increasing evidence for weight-based discrimination against persons with obesity. This study aimed to examine the physiological impact of perceived weight discrimination on cortisol in hair, an indicator of chronic stress exposure. METHODS: Data were from 563 nonsmoking individuals with obesity (body mass index, BMI ≥30 kg/m(2) ) participating in the English Longitudinal Study of Ageing. Experiences of discrimination were reported via questionnaire, and hair cortisol concentrations were determined from the scalp-nearest 2-cm hair segment...
October 14, 2016: Obesity
Ryan W Grant, Jacqueline I Boudreaux, Jacqueline M Stephens
OBJECTIVE: To determine the influence of glycolytic inhibition on the adipocyte inflammatory response. METHODS: To determine the effect of 2-deoxyglucose (2-DOG) on the inflammatory response, mature 3T3-L1 adipocytes were co-treated with 2-DOG and LPS or TNF. To determine the effect of endoplasmic reticulum stress on TNF-induced induction of chemokines, adipocytes were pretreated with thapsigargin or salubrinal. Chemokine mRNA levels were determined using quantitative real-time PCR, and secretion of CCL2 was determined by Western blot...
October 5, 2016: Obesity
David Sánchez-Infantes, Rubén Cereijo, Marion Peyrou, Irene Piquer-Garcia, Jacqueline M Stephens, Francesc Villarroya
OBJECTIVE: Since oncostatin m (OSM) is elevated in adipose tissue in conditions of obesity and type 2 diabetes in mice and humans, the aim of this study was to determine whether this cytokine plays a crucial role in the impairment of brown adipose tissue (BAT) activity and browning capacity that has been observed in people with obesity. METHODS: C57BL/6J mice rendered obese by high-fat diet, their lean controls, and C57BL/6J mice fed a standard diet and implanted subcutaneously with a mini pump through a surgical procedure to deliver OSM or placebo were used...
October 5, 2016: Obesity
Geng Zong, Zefeng Zhang, Quanhe Yang, Hongyu Wu, Frank B Hu, Qi Sun
OBJECTIVE: Associations of overall and regional body fat measured by dual-energy X-ray absorptiometry with total and cause-specific mortality in the National Health and Nutrition Examination Survey (NHANES) 1999-2006 were investigated. METHODS: This study included 9,471 participants (≥20 years) free of major chronic diseases at baseline. Death information was obtained from the National Death Index (mean follow-up duration: 8.8 years). RESULTS: A total of 682 participants died after 12 months since baseline, with 206 and 170 deaths attributed to cardiovascular diseases (CVD) and cancer, respectively...
September 26, 2016: Obesity
Xuwei Hou, Wei Wu, Bo Yin, Xuefeng Liu, Fu Ren
OBJECTIVE: Glucose-stimulated insulin secretion (GSIS) is known to be essential in the control of metabolic fuel homeostasis, though the molecular mechanisms involved remain unclear. METHODS: MicroRNA (miRNA)-463-3p and ATP-binding cassette A4 (ABCG4) expression was analyzed by real-time PCR, and the potential role of miRNA-463-3p or ABCG4 was evaluated by overexpressing or silencing such miRNA or genes. RESULTS: The miRNA-463-3p inhibited GSIS without affecting cell viability...
September 24, 2016: Obesity
Christina P Moldovan, Abby J Weldon, Noha S Daher, Louise E Schneider, Denise L Bellinger, Lee S Berk, Alyson C Hermé, Adam L Aréchiga, Willie L Davis, Warren R Peters
OBJECTIVE: To examine the effects of phentermine combined with a meal replacement program on weight loss and food cravings and to investigate the relationship between food cravings and weight loss. METHODS: In a 12-week randomized, double-blind, placebo-controlled clinical trial, 77 adults with obesity received either phentermine or placebo. All participants were provided Medifast(®) meal replacements, were instructed to follow the Take Shape for Life(®) Optimal Weight 5&1 Plan for weight loss, and received lifestyle coaching in the Habits of Health program...
September 24, 2016: Obesity
Maria Licursi, Christian O Alberto, Alex Dias, Kensuke Hirasawa, Michiru Hirasawa
OBJECTIVE: High-fat diet (HFD) is known to induce low-grade hypothalamic inflammation. Whether inflammation occurs in other brain areas remains unknown. This study tested the effect of short-term HFD on cytokine gene expression and identified leukemia inhibitory factor (LIF) as a responsive cytokine in the brain stem. Thus, functional and cellular effects of LIF in the brain stem were investigated. METHODS: Male rats were fed chow or HFD for 3 days, and then gene expression was analyzed in different brain regions for IL-1β, IL-6, TNF-α, and LIF...
September 24, 2016: Obesity
Qibin Qi, Stephanie M Gogarten, Leslie S Emery, Tin Louie, Adrienne Stilp, Jianwen Cai, Neil Schneiderman, M Larissa Avilés-Santa, Robert C Kaplan, Kari E North, Cathy C Laurie, Ruth J F Loos, Carmen R Isasi
OBJECTIVE: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. METHODS: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos...
September 24, 2016: Obesity
AnneMarie Gagnon, Teik C Ooi, Marion Cousins, Colette Favreau, Kathy Henry, Anne Landry, Alexander Sorisky
OBJECTIVE: To determine the effect of (1) an oral fat load and (2) pro-protein convertase subtilisin/kexin type (PCSK) 9 loss-of-function (LOF) variant status on the ability of peripheral blood mononuclear cells (PBMC) to inhibit human adipogenesis. METHODS: PBMC from subjects with one or more PCSK9 LOF variants versus non-variant controls were compared in the fasting state and after an oral fat load. RESULTS: Fasting triglyceride (TG) levels were lower in the LOF variant versus non-variant group but rose to the same level after the oral fat load...
September 24, 2016: Obesity
Michelle I Cardel, Sarah Chavez, Jiang Bian, Eribeth Peñaranda, Darci R Miller, Tianyao Huo, François Modave
OBJECTIVE: To systematically assess the quality of online information related to weight loss that Spanish speakers in the U.S. are likely to access. METHODS: This study evaluated the accessibility and quality of information for websites that were identified from weight loss queries in Spanish and compared this with previously published results in English. The content was scored with respect to five dimensions: nutrition, physical activity, behavior, pharmacotherapy, and surgical recommendations...
September 21, 2016: Obesity
Stacey Ishman, Christine Heubi, Todd Jenkins, Marc Michalsky, Narong Simakajornboon, Thomas Inge
OBJECTIVE: Obstructive sleep apnea (OSA) is reported in 70% of adolescents who present for bariatric surgery. The Pediatric Sleep Questionnaire (PSQ) was developed to identify children at risk for OSA but is not validated in adolescents with obesity. The aims of this study were: (1) to assess validity of the PSQ to detect OSA and (2) to determine the correlation between anthropometric and polysomnography measurements. METHODS: A cross-sectional assessment of Teen-Longitudinal Assessment of Bariatric Surgery participants at high risk for OSA was performed...
September 15, 2016: Obesity
Molly L Tanenbaum, Kathryn M Ross, Rena R Wing
OBJECTIVE: Daily self-weighing is an effective weight loss strategy. Little is known about "micro" factors influencing nonadherence to self-weighing (e.g., daily overeating). It was hypothesized that increased caloric intake on a given day would increase odds of not self-weighing the following day. METHODS: Daily self-reports of weight and caloric intake were collected from 74 adults with overweight and obesity (mean BMI = 31.2 ± 4.5 kg/m(2) , age = 50...
September 13, 2016: Obesity
Yongjia Li, Tsuyoshi Goto, Ryuma Ikutani, Shan Lin, Nobuyuki Takahashi, Haruya Takahashi, Huei-Fen Jheng, Rina Yu, Masahiko Taniguchi, Kimiye Baba, Shigeru Murakami, Teruo Kawada
OBJECTIVE: Obesity-induced inflammation plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. Xanthoangelol (XA) and 4-hydroxyderrcin (4-HD), phytochemicals extracted from Angelica keiskei, have been reported to possess various biological properties. Whether XA and 4-HD alleviate obesity-induced inflammation and inflammation-induced adipocyte dysfunction was investigated. METHODS: For the in vitro study, a co-culture system composed of macrophages and adipocytes and macrophages stimulated with conditioned medium derived from fully differentiated adipocytes was conducted...
September 13, 2016: Obesity
Ariana M Chao, Thomas A Wadden, Lucy F Faulconbridge, David B Sarwer, Victoria L Webb, Jena A Shaw, J Graham Thomas, Christina M Hopkins, Zayna M Bakizada, Naji Alamuddin, Noel N Williams
OBJECTIVE: A previous study reported that preoperative binge-eating disorder (BED) did not attenuate weight loss at 12 months after bariatric surgery. This report extends the authors' prior study by examining weight loss at 24 months. METHODS: A modified intention-to-treat population was used to compare 24-month changes in weight among 59 participants treated with bariatric surgery, determined preoperatively to be free of a current eating disorder, with changes in 33 surgically treated participants with BED...
September 12, 2016: Obesity
Delia Smith West, Jean R Harvey, Rebecca A Krukowski, T Elaine Prewitt, Jeffrey Priest, Takamaru Ashikaga
OBJECTIVE: To examine whether the addition of online motivational interviewing (MI) chats to a Web-based, group behavioral obesity treatment program augments weight loss outcomes relative to the Web-based weight control program alone. METHODS: Healthy individuals (N = 398, 24% minority) with overweight/obesity were randomized to a 36-session group Internet behavioral weight control treatment (BT) or the same group Internet treatment plus six individual MI chat sessions (BT + MI)...
September 12, 2016: Obesity
Hanneke van Helden, Christine M van Seters, Janneke van Leeuwen, Arthur M Bohnen
No abstract text is available yet for this article.
September 12, 2016: Obesity
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