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Nichole Jannah, Jeff Hild, Christine Gallagher, William Dietz
OBJECTIVE: This study examined changes in coverage for adult obesity treatment services in Medicaid and state employee health insurance programs between 2009 and 2017. METHODS: Administrative materials from Medicaid and state employee health insurance programs in all 50 states and the District of Columbia were reviewed for indications of coverage and payment policies specific to evidence-based treatment modalities for adults (≥ 21 years of age) with obesity, including nutritional counseling, pharmacotherapy, and bariatric surgery...
November 14, 2018: Obesity
Clemence Girardet, Daniel L Marks, Andrew A Butler
OBJECTIVE: Activation of hypothalamic agouti-related peptide expressing (AgRP)+ve neurons during energy deficit is a negative valence signal, rapidly activating food-seeking behaviors. This study examined the roles of melanocortin-3 receptors (MC3Rs) coexpressed in a subpopulation of AgRP+ve neurons. METHODS: AgRP-MC3R mice expressing MC3Rs selectively in AgRP+ve neurons were generated by crossing AgRP-IRES-Cre mice with LoxTBMc3r mice containing a "loxP-STOP-loxP" sequence in the 5' untranslated region...
November 14, 2018: Obesity
Molly B Richardson, Peng Li, Julia M Gohlke, David B Allison
OBJECTIVE: It was hypothesized that exposure to mild temperatures above the human thermoneutral zone would decrease caloric intake in a sedentary office environment. METHODS: Women (n = 25) were randomized in a crossover design to perform seated office work for 7 hours in a thermoneutral condition (control, 19°C-20°C) and a condition above the thermoneutral zone (warm, 26°C-27°C). Food intake was estimated by weight and bomb calorimetry, peripheral temperature by thermal imaging, and thermal comfort and productivity by questionnaires...
November 14, 2018: Obesity
Emma J Stinson, Susanne B Votruba, Colleen Venti, Marisol Perez, Jonathan Krakoff, Marci E Gluck
OBJECTIVE: The association between food insecurity and obesity may be partially explained by overeating in response to unpredictable food availability cycles. The aim of this study was to measure objective food intake in food-insecure individuals. METHODS: Eighty-two volunteers (53 m; BMI 29 ± 7; 38 ± 12 years) were admitted to our inpatient Clinical Research Unit and completed the Food Security Short Form, Three-Factor Eating Questionnaire, Gormally Binge Eating Scale, and body composition assessment (dual-energy x-ray absorptiometry)...
November 14, 2018: Obesity
Erica G Soltero, Micah L Olson, Allison N Williams, Yolanda P Konopken, Felipe G Castro, Kimberly J Arcoleo, Colleen S Keller, Donald L Patrick, Stephanie L Ayers, Estela Barraza, Gabriel Q Shaibi
OBJECTIVE: This study examined the short- and long-term effects of a community-based lifestyle intervention among Latino youth with obesity. METHODS: Latino adolescents (14-16 years old) were randomized to a 3-month lifestyle intervention (n = 67) or comparison control (n = 69) and followed for 12 months. The intervention included weekly nutrition and health classes delivered to groups of families and exercise sessions (3 days/week) delivered to groups of adolescents...
November 14, 2018: Obesity
Suzanne Phelan, Rena R Wing, Anna Brannen, Angelica McHugh, Todd Hagobian, Andrew Schaffner, Elissa Jelalian, Chantelle N Hart, Theresa O Scholl, Karen Muñoz-Christian, Elaine Yin, Maureen G Phipps, Sarah Keadle, Barbara Abrams
OBJECTIVE: This randomized trial tested whether a behavioral intervention with meal replacements in pregnancy could increase the proportion of women who returned to prepregnancy weight and reduce postpartum weight retention by 12 months after delivery. METHODS: Women (N = 264; 13.7 weeks' gestation) with overweight or obesity were randomly assigned to usual care or intervention. The intervention reduced excess gestational weight gain and was discontinued at delivery...
November 13, 2018: Obesity
Jamy D Ard, Kristina H Lewis, Amy Rothberg, Anthony Auriemma, Sally L Coburn, Sarah S Cohen, Judy Loper, Laura Matarese, Walter J Pories, Seletha Periman
OBJECTIVE: The aim of this study was to test the effectiveness of the OPTIFAST program (OP), a total meal replacement dietary intervention, compared with a food-based (FB) dietary plan for weight loss. METHODS: Participants with BMI 30 to 55 kg/m2 , age 18 to 70 years old, were randomized to OP or FB dietary and lifestyle interventions for 26 weeks, followed by a weight-maintenance phase. Outcomes were percent change in body weight (%WL) from baseline to weeks 26 and 52, associated changes in body composition (using dual energy x-ray absorptiometry), and adverse events...
November 13, 2018: Obesity
Dylan D Thomas, Wendy A Anderson, Caroline M Apovian, Donald T Hess, Liqun Yu, Amanda Velazquez, Brian Carmine, Nawfal W Istfan
OBJECTIVE: Weight recidivism following Roux-en-Y gastric bypass (RYGB) is common and is associated with recurrence of comorbidities. Studies with long-term follow-up of recidivism quantified by weight regain (WR) are lacking. A retrospective review of all RYGB at our center from 2004 to 2015 was performed to examine the effects of race and type 2 diabetes on WR following RYGB. METHODS: Multivariable linear mixed models were used for the effects of time and race on weight, WR relative to nadir weight (WR/nadir), and WR relative to maximal weight loss, and Cox regressions were used for low, moderate, and high WR/nadir...
November 13, 2018: Obesity
Michelle I Cardel, Suhong Tong, Greg Pavela, Emily Dhurandhar, Darci Miller, Richard Boles, Matthew Haemer
OBJECTIVE: Subjective social status (SSS), perceived rank in the social ladder, is associated with weight, but determinants of SSS in youth remain unknown. Relationships between youth SSS and income, food insecurity, parent SSS, and BMI change were investigated during an obesity intervention. METHODS: Data came from a family-centered, community-based obesity intervention for low-income families. Parent and youth SSS were assessed using a validated, age-appropriate SSS scale...
November 13, 2018: Obesity
Mette Søndergaard Nielsen, Simone Rasmussen, Bodil Just Christensen, Christian Ritz, Carel W le Roux, Julie Berg Schmidt, Anders Sjödin
OBJECTIVE: Using an ad libitum buffet meal targeting direct behavior, the authors of the current study previously reported no effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery on food preferences 6 months after surgery. The current study investigated changes in food preferences at 18 months after surgery and whether changes in food preferences at 6 months predicted weight loss. METHODS: Twenty food items separated into the following food categories were served at the buffet meal: high-fat, low-fat, sweet, savory, high-fat savory, high-fat sweet, low-fat savory, and low-fat sweet...
November 13, 2018: Obesity
Thomas A Wadden, Olivia A Walsh, Robert I Berkowitz, Ariana M Chao, Naji Alamuddin, Kathryn Gruber, Sharon Leonard, Kimberly Mugler, Zayna Bakizada, Jena Shaw Tronieri
OBJECTIVE: The Centers for Medicare and Medicaid Services (CMS) covers intensive behavioral therapy (IBT) for obesity. The efficacy, however, of the specific approach has never been evaluated in a randomized trial, as described here. The 1-year trial also assessed whether the addition to IBT of liraglutide 3.0 mg would significantly increase weight loss and whether the provision of meal replacements would add further benefit. METHODS: A total of 150 adults with obesity were randomly assigned to: IBT (IBT-alone), providing 21 counseling visits; IBT combined with liraglutide (IBT-liraglutide); or IBT-liraglutide combined for 12 weeks with a 1,000- to 1,200-kcal/d meal-replacement diet (Multicomponent)...
November 13, 2018: Obesity
Alison E Field, Thomas H Inge, Steven H Belle, Geoffrey S Johnson, Abdus S Wahed, Walter J Pories, Konstantinos Spaniolas, James E Mitchell, Alfons Pomp, Gregory F Dakin, Bruce Wolfe, Anita P Courcoulas
OBJECTIVE: The study objective was to empirically identify subgroups of patients with obesity and investigate their association with postoperative weight change. METHODS: A longitudinal analysis of 2,458 adults in the Longitudinal Assessment of Bariatric Surgery (LABS) study was used. Baseline data were used to identify subgroups. The outcome was 3-year weight change after bariatric surgery. RESULTS: We identified four classes (subtypes) of obesity, which could be characterized as diabetes with low rates of high-density lipoprotein (Class 1), disordered eating (Class 2), mixed (Class 3), and extreme obesity with early onset (Class 4)...
November 13, 2018: Obesity
Ariana M Chao, Thomas A Wadden, Jena Shaw Tronieri, Robert I Berkowitz
OBJECTIVE: This study aimed to assess whether alcohol consumption decreases during an intensive lifestyle intervention (ILI) and whether alcohol consumption is associated with weight loss among participants with overweight or obesity and type 2 diabetes. METHODS: Participants (n = 4,901) were from the Action for Health in Diabetes (Look AHEAD) study, a randomized controlled trial that compared an ILI with a diabetes support and education (DSE) control. Mixed-effects models were used to estimate the effect of the ILI on alcohol consumption and the influence of alcohol consumption on weight loss at year 4...
November 13, 2018: Obesity
Matthew L Maciejewski, David E Arterburn, Theodore S Z Berkowitz, Hollis J Weidenbacher, Chuan-Fen Liu, Maren K Olsen, Luke M Funk, James E Mitchell, Valerie A Smith
OBJECTIVE: This study aims to describe geographic variation in veterans' prevalence of obesity, participation in Veterans Health Administration's behavioral weight management program (MOVE!), and receipt of bariatric surgery in fiscal year (FY) 2016. METHODS: In this retrospective cohort study of veterans with obesity who received Veterans Health Administration care in FY2016, electronic health record data were obtained on weight, height, outpatient visits to the MOVE! program, and bariatric surgeries...
November 13, 2018: Obesity
Frank L Greenway, Louis J Aronne, Anne Raben, Arne Astrup, Caroline M Apovian, James O Hill, Lee M Kaplan, Ken Fujioka, Erika Matejkova, Stepan Svacina, Livio Luzi, Lucio Gnessi, Santiago Navas-Carretero, J Alfredo Martinez, Christopher D Still, Alessandro Sannino, Cosimo Saponaro, Christian Demitri, Lorien E Urban, Harry Leider, Elaine Chiquette, Eyal S Ron, Yishai Zohar, Hassan M Heshmati
OBJECTIVE: This study aims to assess the efficacy and safety of Gelesis100, a novel, nonsystemic, superabsorbent hydrogel to treat overweight or obesity. METHODS: The Gelesis Loss Of Weight (GLOW) study was a 24-week, multicenter, randomized, double-blind, placebo-controlled study in patients with BMI ≥  27 and ≤ 40 kg/m2 and fasting plasma glucose ≥ 90 and ≤ 145 mg/dL. The co-primary end points were placebo-adjusted weight loss (superiority and 3% margin super-superiority) and at least 35% of patients in the Gelesis100 group achieving ≥ 5% weight loss...
November 13, 2018: Obesity
KayLoni L Olson, Jason Lillis, J Graham Thomas, Rena R Wing
OBJECTIVE: Internalized weight bias (IWB) has been associated with weight regain after intentional weight loss, but reliance on cross-sectional data limits the understanding of this relationship. This study prospectively evaluated IWB as a predictor of weight change in a longitudinal observational study of successful weight-loss maintainers. METHODS: National Weight Control Registry participants (maintained 13.6-kg weight loss for ≥ 1 y) were asked to complete an online questionnaire including current weight and Weight Bias Internalization Scale-Modified (WBIS-M) at baseline and 12 months...
November 13, 2018: Obesity
Eric Ravussin
No abstract text is available yet for this article.
November 13, 2018: Obesity
Brett T Venker, Julia P Dunn, Kevin Stephenson
The cost of treating diabetes mellitus has risen sharply in recent years because of an increasing number of patients with type 2 diabetes and obesity and a rapidly expanding repertoire of expensive nongeneric medications. Despite the call for a new treatment paradigm by the American Diabetes Association to mitigate this cost, recent Medicare Part D expenditure data show that this call remains unanswered. The Diabetes Remission Clinical Trial, published in The Lancet, adds support to a different path, demonstrating success with intensive lifestyle intervention followed by structured support for long-term weight loss maintenance...
November 12, 2018: Obesity
Margery J Tamas, Anjali Khakharia, Richard B Rothenberg, Lawrence S Phillips
OBJECTIVE: The aim of this study was to assess weight trends and diabetes prevalence among US veterans. METHODS: Information from the Veterans Affairs Informatics and Computing Infrastructure Corporate Data Warehouse was used to construct data sets that included demographic data, diabetes status, and weight observations for males and females. Secular and longitudinal trends in mean weight were analyzed. RESULTS: A total of 4,527,865 patients born from 1915 to 1984 with weight data during 2000 to 2014 were included; 36...
November 12, 2018: Obesity
Claire Mills, Emily Ryall
No abstract text is available yet for this article.
October 28, 2018: Obesity
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