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Obesity

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https://www.readbyqxmd.com/read/29442440/time-to-peak-weight-loss-during-extended-behavioral-treatment
#1
Meghan L Butryn, Christine C Call, Leah M Schumacher, Stephanie G Kerrigan, Evan M Forman
OBJECTIVE: This study was designed to examine the variability in timing of peak weight loss in behavioral treatment (BT), that is, when treatment participants reach their greatest amount of cumulative weight loss. METHODS: Secondary data analyses were conducted, drawing upon data from two clinical trials that provided 12 months of group-based BT, with sessions meeting less frequently in the second half of the treatment year. Weight was measured at the beginning of each treatment session...
February 14, 2018: Obesity
https://www.readbyqxmd.com/read/29442437/prospective-studies-exploring-the-possible-impact-of-an-id3-polymorphism-on-changes-in-obesity-measures
#2
Mathilde Svendstrup, Emil V R Appel, Camilla H Sandholt, Tarunveer S Ahluwalia, Lars H Ängquist, Betina H Thuesen, Marit E Jørgensen, Oluf Pedersen, Niels Grarup, Torben Hansen, Thorkild I A Sørensen, Henrik Vestergaard
OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans. METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years...
February 14, 2018: Obesity
https://www.readbyqxmd.com/read/29427376/longitudinal-increases-in-adiposity-contribute-to-worsening-adipokine-profile-over-time-in-mexican-americans
#3
Mary Helen Black, Yu-Hsiang Shu, Jun Wu, Corinna Koebnick, Adrienne MacKay, Richard M Watanabe, Thomas A Buchanan, Anny H Xiang
OBJECTIVE: Limited studies have assessed the relationship between longitudinal changes in adiposity and changes in multiple adipokines over time. This study examined changes in BMI, total body fat, and trunk fat associated with changes in 16 circulating adipokines in Mexican Americans at risk for type 2 diabetes. METHODS: Participants included 1,213 individuals with cross-sectional data and a subset of 368 individuals with follow-up measures (mean 4.6 ± 1.5 years from baseline)...
February 10, 2018: Obesity
https://www.readbyqxmd.com/read/29427370/weight-stigma-predicts-poorer-psychological-well-being-through-internalized-weight-bias-and-maladaptive-coping-responses
#4
Lydia E Hayward, Lenny R Vartanian, Rebecca T Pinkus
OBJECTIVE: Weight-based stigmatization is associated with negative psychological and behavioral consequences, but individuals respond to stigma in different ways. The present study aimed to understand some of the factors that predict how one will cope with weight stigma and how different coping responses predict psychological well-being. METHODS: Across four samples, 1,391 individuals who identified as having overweight or obesity completed surveys assessing the frequency of weight stigma experiences, internalized weight bias, coping responses to weight stigma, and psychological distress...
February 10, 2018: Obesity
https://www.readbyqxmd.com/read/29405636/dietary-curcumin-intervention-targets-mouse-white-adipose-tissue-inflammation-and-brown-adipose-tissue-ucp1-expression
#5
Zhuolun Song, Xavier Revelo, Weijuan Shao, Lili Tian, Kejing Zeng, Helena Lei, Hong-Shuo Sun, Minna Woo, Daniel Winer, Tianru Jin
OBJECTIVE: This study aimed to determine whether dietary curcumin intervention targets both white adipose tissue (WAT) inflammation and brown adipose tissue (BAT)-mediated energy expenditure. METHODS: C57BL/6J mice were fed with a low-fat diet, high-fat diet (HFD), or HFD plus curcumin. In addition to assessing the effect of curcumin intervention on metabolic profiles, this study assessed WAT macrophage infiltration and composition and inflammatory cytokine production...
February 6, 2018: Obesity
https://www.readbyqxmd.com/read/29400004/trends-in-obesity-overweight-and-thinness-in-children-in-the-seychelles-between-1998-and-2016
#6
Rim Aly, Bharathi Viswanathan, Gaynor Mangroo, Jude Gedeon, Pascal Bovet
OBJECTIVE: This study assessed trends in the prevalence of children and adolescents with obesity, overweight, and thinness in the Seychelles, a rapidly developing nation in the Indian Ocean, and changes in the distribution of BMI over time. METHODS: Between 1998 and 2016, examination surveys were conducted every year in all students of four selected school grades (kindergarten, primary 4, secondary 1, and secondary 4) in all schools. We categorized BMI by using the International Obesity Task Force criteria...
February 5, 2018: Obesity
https://www.readbyqxmd.com/read/29399981/maternal-metabolic-health-parameters-during-pregnancy-in-relation-to-early-childhood-bmi-trajectories
#7
Parisa Montazeri, Martine Vrijheid, David Martinez, Mikel Basterrechea, Ana Fernandez-Somoano, Monica Guxens, Carmen Iñiguez, Aitana Lertxundi, Mario Murcia, Adonina Tardon, Jordi Sunyer, Damaskini Valvi
OBJECTIVE: The objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories. METHODS: Two thousand two hundred fifty-one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories...
February 5, 2018: Obesity
https://www.readbyqxmd.com/read/29399976/combined-analysis-of-stress-and-ecm-related-genes-in-their-effect-on-weight-regain
#8
Nadia J T Roumans, Ping Wang, Roel G Vink, Marleen A van Baak, Edwin C M Mariman
OBJECTIVE: During weight loss, the volume of adipocytes decreases, leading to stress because of the misfit between the cell contents and the surrounding extracellular matrix (ECM). This stress can be resolved by remodeling the ECM or the restorage of triglycerides within the adipocytes. The objective of this study was to investigate the existence of a connection between stress-related and ECM-related genes that is associated with weight regain. METHODS: Thirty-one participants with overweight or obesity followed a 5-week very-low-calorie diet (500 kcal/d) with a subsequent 4-week weight-stable diet (WS), and then an uncontrolled 9-month follow-up...
February 5, 2018: Obesity
https://www.readbyqxmd.com/read/29399971/benefits-and-harms-in-pivotal-trials-of-oral-centrally-acting-antiobesity-medicines-a-systematic-review-and-meta-analysis
#9
Igho J Onakpoya, Dylan R J Collins, Niklas J H Bobrovitz, Jeffrey K Aronson, Carl J Heneghan
OBJECTIVE: To evaluate the benefits and harms of oral centrally acting antiobesity medicinal products in pivotal trials. METHODS: The European Medicines Agency and Federal Drug Administration websites, PubMed, and ClinicalTrials.gov were searched to identify pivotal trials used to gain marketing authorizations. Pivotal phase III trials on which marketing authorizations were based were included. The data were analyzed by using Cochrane Review Manager (RevMan), and quality assessments for each outcome were performed by using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE)...
February 5, 2018: Obesity
https://www.readbyqxmd.com/read/29388733/attempts-to-lose-weight-among-us-children-importance-of-weight-perceptions-from-self-parents-and-health-professionals
#10
Jiying Ling, Manfred Stommel, Seung Hee Choi
OBJECTIVE: The objective of this study was to investigate how perceptions of weight by children themselves, parents, and health professionals influence children's persistent attempts to lose weight. METHODS: The sample included 4,914 children aged 8 to 15 years from the 2005 to 2014 National Health and Nutrition Examination Survey (representing 20.7 million children). Data were analyzed using logistic regression models. RESULTS: About 34.2% never made an effort to lose weight, whereas 28...
February 1, 2018: Obesity
https://www.readbyqxmd.com/read/29388385/randomized-controlled-trial-examining-the-ripple-effect-of-a-nationally-available-weight-management-program-on-untreated-spouses
#11
Amy A Gorin, Erin M Lenz, Talea Cornelius, Tania Huedo-Medina, Alexis C Wojtanowski, Gary D Foster
OBJECTIVE: For married couples, when one spouse participates in weight loss treatment, the untreated spouse can also experience weight loss. This study examined this ripple effect in a nationally available weight management program. METHODS: One hundred thirty dyads were randomized to Weight Watchers (WW; n = 65) or to a self-guided control group (SG; n = 65) and assessed at 0, 3, and 6 months. Inclusion criteria were age ≥ 25 years, BMI 27 to 40 kg/m 2 (≥ 25 kg/m 2 for untreated spouses), and no weight loss contraindications...
February 1, 2018: Obesity
https://www.readbyqxmd.com/read/29377571/transcriptional-regulatory-mechanisms-in-adipose-and-muscle-tissue-associated-with-composite-glucometabolic-phenotypes
#12
Carl D Langefeld, Mary E Comeau, Neeraj K Sharma, Donald W Bowden, Barry I Freedman, Swapan K Das
OBJECTIVE: Tissue-specific gene expression is associated with individual metabolic measures. However, these measures may not reflect the true but latent underlying biological phenotype. This study reports gene expression associations with multidimensional glucometabolic characterizations of obesity, glucose homeostasis, and lipid traits. METHODS: Factor analysis was computed by using orthogonal rotation to construct composite phenotypes (CPs) from 23 traits in 256 African Americans without diabetes...
January 29, 2018: Obesity
https://www.readbyqxmd.com/read/29377630/upregulation-of-foreign-body-response-in-obese-mice
#13
Laura Alejandra Ariza Orellano, Simone Aparecida de Almeida, Luciana Xavier Pereira, Letícia Chinait Couto, Marcela Guimarães Takahashi de Lazari, Celso Tarso Rodrigues Viana, Silvia Passos Andrade, Paula Peixoto Campos
OBJECTIVE: Obesity is a highly prevalent multifactorial metabolic condition in which the need for functional bioengineered substitutes (e.g., scaffolds for tissue engineering) is likely to occur. However, the adverse foreign body response (FBR) that invariably takes place adjacent to implant devices impairing their function is poorly characterized in this condition. This study investigated the influence of obesity on the host response to a synthetic matrix implanted subcutaneously in high-fat-fed obese mice...
January 27, 2018: Obesity
https://www.readbyqxmd.com/read/29377622/influence-of-childhood-and-adolescent-fat-development-on-fat-mass-accrual-during-emerging-adulthood-a-20-year-longitudinal-study
#14
Erin Barbour-Tuck, Marta Erlandson, Nazeem Muhajarine, Heather Foulds, Adam Baxter-Jones
OBJECTIVE: Fat mass and the prevalence of overweight/obesity (OWO) increase during emerging adulthood (EA; 18-25 years). The factors that contribute to the transition from having healthy weight to having OWO during EA are understudied. This study aimed to identify the independent effect of concurrent physical activity (PA) and energy intake (EI) and childhood/adolescent fat accrual, PA, and EI on EA fat accrual. METHODS: One hundred twenty-six participants (59 male) were measured serially between 1991 and 2011...
January 27, 2018: Obesity
https://www.readbyqxmd.com/read/29352524/effects-of-physical-activity-and-sedentary-behavior-on-brain-response-to-high-calorie-food-cues-in-young-adults
#15
Shan Luo, Sydney G O'Connor, Britni R Belcher, Kathleen A Page
OBJECTIVE: Physical activity (PA) promotes weight maintenance, potentially because of its beneficial effects on feeding behavior regulation via diminished food cue reactivity within brain reward regions. This study examined how levels of PA and sedentary behavior (SB) relate to brain responses to food cues. METHODS: Participants (22 lean, 18 with obesity) completed three to five PA recalls over 2 months. Average minutes per day of moderate to vigorous PA (MVPA) and SB were calculated...
January 19, 2018: Obesity
https://www.readbyqxmd.com/read/29288545/a-randomized-trial-of-lorcaserin-and-lifestyle-counseling-for-maintaining-weight-loss-achieved-with-a-low-calorie-diet
#16
Jena Shaw Tronieri, Thomas A Wadden, Robert I Berkowitz, Ariana M Chao, Rebecca L Pearl, Naji Alamuddin, Sharon M Leonard, Ray Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions. METHODS: This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5% of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9...
December 29, 2017: Obesity
https://www.readbyqxmd.com/read/29286209/precision-of-dxa-derived-visceral-fat-measurements-in-a-large-sample-of-adults-of-varying-body-size
#17
Kim Meredith-Jones, Jillian Haszard, Nigel Stanger, Rachael Taylor
OBJECTIVE: The aim of this study was to determine the precision of GE Lunar's CoreScan tool (GE Healthcare, Madison, Wisconsin) for measuring visceral adipose tissue (VAT) in adults of varying body size. METHODS: Two consecutive dual-energy x-ray absorptiometry (DXA) scans with repositioning were undertaken in 233 participants (110 male, 123 female) aged 18 to 70 years; 38% (n = 89) had normal weight, 34% (n = 80) had overweight, and 27% (n = 64) had obesity...
December 29, 2017: Obesity
https://www.readbyqxmd.com/read/29282881/the-negative-influence-of-adiposity-extends-to-intraindividual-variability-in-cognitive-control-among-preadolescent-children
#18
Morgan R Chojnacki, Lauren B Raine, Eric S Drollette, Mark R Scudder, Arthur F Kramer, Charles H Hillman, Naiman A Khan
OBJECTIVE: The objective of this study was to investigate the relationship between adiposity and cognition by using mean accuracy, mean reaction time, and intraindividual variability (IIV) among preadolescents. METHODS: Children 7 to 9 years old (N = 233, 133 females) underwent dual-energy x-ray absorptiometry and a maximal oxygen consumption test to assess whole-body adiposity and aerobic fitness relative to fat-free mass (VO2 FF), respectively. Attentional inhibition was assessed by using a modified flanker task...
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29282873/reconsidering-the-psychosocial-behavioral-evaluation-required-prior-to-bariatric-surgery
#19
EDITORIAL
Rebecca L Pearl, Kelly C Allison, Jena Shaw Tronieri, Thomas A Wadden
No abstract text is available yet for this article.
December 27, 2017: Obesity
https://www.readbyqxmd.com/read/29280341/body-mass-index-and-subjective-social-status-the-coronary-artery-risk-development-in-young-adults-study
#20
Emily J Dhurandhar, Gregory Pavela, Kathryn A Kaiser, Gareth R Dutton, Kevin R Fontaine, Daniel Kim, James M Shikany, David B Allison, Cora E Lewis
OBJECTIVE: Subjective social status (SSS), or perceived social status, may explain, in part, the relationship between socioeconomic status (SES) and obesity. The objective of this study was to test whether SSS mediates the relationship between two indicators of SES (income and education) and body mass index (BMI). METHODS: A cross-sectional, structural equation path analysis was applied to the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 2,624)...
December 27, 2017: Obesity
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