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Clinical Research in Cardiology: Official Journal of the German Cardiac Society

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https://www.readbyqxmd.com/read/30006658/from-early-beginnings-to-elaborate-tools-contribution-of-german-electrophysiology-to-the-interventional-treatment-of-cardiac-arrhythmias-the-german-cardiac-society-welcomes-esc-in-munich-2018
#1
REVIEW
Thomas Fink, Michael Schlüter, Karl-Heinz Kuck
Catheter ablation evolved from the early days of cardiac electrophysiology (EP), in which invasive electrophysiological studies were mainly a tool to find the correct diagnosis and to evaluate the most effective anti-arrhythmic drug for the patient. Today, catheter ablation is the most effective treatment option for patients suffering from supraventricular and ventricular arrhythmias. The understanding of cardiac arrhythmias and treatment strategies improved because of physicians and scientists from all over the world...
July 13, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/30003366/transcatheter-valve-in-valve-implantation-vinv-tavr-for-failed-surgical-aortic-bioprosthetic-valves
#2
Bernhard Wernly, Ann-Katrin Zappe, Axel Unbehaun, Jan-Malte Sinning, Christian Jung, Won-Keun Kim, Stephan Fichtlscherer, Michael Lichtenauer, Uta C Hoppe, Brunilda Alushi, Frederick Beckhoff, Charlotte Wewetzer, Marcus Franz, Daniel Kretzschmar, Eliano Navarese, Ulf Landmesser, Volkmar Falk, Alexander Lauten
OBJECTIVE: We sought to investigate the procedural and hemodynamic outcome after valve-in-valve transcatheter aortic valve replacement (VinV-TAVR) for different surgical (SBV) and transcatheter (TAVR) bioprosthetic valves. METHODS AND RESULTS: 223 patients (76 ± 11years, STS-Score 8.3 ± 10.1) suffering from SBV failure treated with VinV-TAVR were enrolled at 6 centers across Germany. At time of the intervention, the majority of patients were in NYHA-class ≥ III (88%, n = 180)...
July 12, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/30003365/long-term-effects-of-iron-deficiency-in-patients-with-heart-failure-with-or-without-anemia-the-raid-hf-follow-up-study
#3
Harm Wienbergen, Otmar Pfister, Matthias Hochadel, Andreas Fach, Tina Backhaus, Oliver Bruder, Björn Andrew Remppis, Micha Tobias Maeder, Wolfgang von Scheidt, Matthias Pauschinger, Jochen Senges, Rainer Hambrecht
INTRODUCTION: Iron deficiency (ID) has been recognized as a relevant comorbidity in heart failure with reduced ejection fraction (HFrEF); however, study data have shown that diagnostic and therapeutic efforts on ID are primarily performed in patients with anemia. METHODS: The RAID-HF registry investigated consecutive patients with ID and HFrEF in 11 heart centers in Germany and Switzerland. The present analysis focuses on 1-year follow-up data in patients with versus without anemia...
July 12, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29995218/lmu-munich-platelet-inhibition-novel-aspects-on-platelet-inhibition-and-function
#4
REVIEW
Lisa Gross, Dirk Sibbing, Christian Schulz, Florian Gärtner, Joachim Pircher, Steffen Massberg, Tobias Petzold
A core research area in the Department of Cardiology at Ludwig-Maximilians-University (LMU) Munich focuses on antiplatelet therapy, its translational aspects, and its underlying mechanism with respect to platelet physiology. We are conducting a broad range of investigator-initiated clinical trials (phase II-IV) and preclinical studies on the topic of antithrombotic therapy for percutaneous coronary intervention patients, platelet activation, and reactivity as well as on novel inhibitors of platelet adhesion...
July 11, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29987596/therapeutic-options-in-advanced-heart-failure
#5
Tarek Bekfani, Florian Westphal, P Christian Schulze
No abstract text is available yet for this article.
July 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29987595/prognostic-significance-of-atrial-fibrillation-in-acute-decompensated-heart-failure-with-reduced-versus-preserved-ejection-fraction
#6
Alexander Jobs, Julia Schwind, Alexander Katalinic, Valentin Babaev, Roland Richard Tilz, Stefan Rausch, Holger Thiele, Ingo Eitel, Charlotte Eitel
OBJECTIVE: The prognostic impact of atrial fibrillation (AF) in patients with acute decompensated heart failure (ADHF) has not been fully elucidated yet. Aim of the present study was thus to investigate the association of AF with all-cause mortality in patients with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). METHODS: We performed a retrospective single center study and analyzed data of 1286 patients admitted for ADHF. Patients were grouped according to AF status (i...
July 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29987594/correction-to-integrating-basic-science-in-academic-cardiology-training-two-international-perspectives-on-a-common-challenge
#7
Michael F Bode, Ingo Hilgendorf
Unfortunately, the + and - signs marking the benefits and challenges in Table 1 have been omitted during the typesetting of the article.
July 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29978353/complex-pci-procedures-challenges-for-the-interventional-cardiologist
#8
REVIEW
Nikos Werner, Georg Nickenig, Jan-Malte Sinning
In recent years, the percentage of patients with multivessel disease and multiple complex stenoses have significantly increased. One factor contributing to this increase is the proportion of elderly and very elderly patients who have been turned down by the Heart Team for surgical revascularization (Landes et al. in Catheter Cardiovasc Interv, https://doi.org/10.1002/ccd.27375 , 2017; Waldo et al. in Circulation 130:2295-2301, https://doi.org/10.1161/CIRCULATIONAHA.114.011541 , 2014). In addition, the marked increase in patients with significant comorbidities further contributes to the increase in patients referred to the interventional cardiologist for stenting procedures...
July 5, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29974195/coronary-computed-tomography-angiography-a-method-coming-of-age
#9
REVIEW
Axel Schmermund, Joachim Eckert, Marco Schmidt, Annett Magedanz, Thomas Voigtländer
In patients with stable symptoms suggestive of coronary artery disease (CAD), coronary CT angiography (CTA) allows for assessing several aspects of coronary atherosclerosis. Coronary artery stenoses are reliably detected, plaque formation can be quantified and characterized as calcified or non-calcified, and markers of potential instability such as expansive vascular remodeling, spotty calcification, and atheroma size can be described. As opposed to invasive coronary angiography, CTA visualizes the vessel lumen and wall...
July 4, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29971564/correction-to-reply-to-the-letter-cardiac-autonomic-evaluation-in-breast-cancer-patients-role-of-cytokines-and-heart-rate-recovery
#10
Claudia Arab, Luiz Carlos Marques Vanderlei, Yori Gidron, Celso Ferreira
Unfortunately, errors occurred in the original article.
July 3, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29968196/progress-in-heart-failure-treatment-in-germany
#11
REVIEW
Mark Luedde, Martina E Spehlmann, Norbert Frey
Acute and chronic heart failure is still a major cause of morbidity and mortality in Europe. Nevertheless, significant progress has been made in diagnosis and treatment of heart failure as well as in unraveling its molecular causes. Here, we focus on some relevant contributions to these achievements by German cardiovascular clinicians and scientists.
July 2, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29968195/correction-to-acute-and-long-term-outcomes-of-epicardial-left-atrial-appendage-ligation-with-the-second-generation-lariat-device-a-high-volume-electrophysiology-center-experience
#12
Thomas Fink, Michael Schlüter, Roland Richard Tilz, Christian-Hendrik Heeger, Christine Lemes, Tilmann Maurer, Bruno Reissmann, Laura Rottner, Francesco Santoro, Shibu Mathew, Andreas Rillig, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner
Unfortunately, an error occurred in the conclusion section of this article. The corrected conclusion text is given below.
July 2, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29955916/patent-foramen-ovale-closure-for-patients-excluded-from-the-randomized-cryptogenic-stroke-trials-response-to-letter-by-zaman-et-al
#13
LETTER
Brunilda Alushi, Alexander Lauten, Ulf Landmesser, Adnan Kastrati
No abstract text is available yet for this article.
June 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29955915/patent-foramen-ovale-closure-for-patients-excluded-from-the-randomized-cryptogenic-stroke-trials
#14
LETTER
Muhammad O Zaman, Nimesh K Patel, Mohammad K Mojadidi
No abstract text is available yet for this article.
June 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29955914/biomarker-in-cardiology-dgk-welcomes-esc-munich-2018
#15
REVIEW
H A Katus, E Giannitsis
Biomarkers have become essential tools for diagnosis and risk stratification in cardiology. This update provides an overview on the development and clinical application of selected biomarkers with a focus on cardiac troponins (cTn). We will specifically indicate the contribution of members of the German Cardiac Society to the field both in test development and evaluation as well as application in clinical care settings. Furthermore, we briefly touch on the development of novel biomarkers and expanded applications in personalized medicine and as companion diagnostics...
June 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29951805/current-developments-in-cardiac-rhythm-management-devices
#16
REVIEW
Philipp Halbfass, Kai Sonne, Karin Nentwich, Elena Ene, Thomas Deneke
Endocardial pacing has experienced a tremendous evolution since the 1960s. A lot of challenges associated with pacemaker and ICD devices have already been successfully targeted. However, a relevant number of problems have not been solved to date. Not all patients with accepted indication for biventricular pacing have benefited from cardiac resynchronisation therapy (CRT) despite extensive efforts to reduce the rate of non-responders. Current strategies to optimize lead position, multipolar left-ventricular (LV) pacing leads, new strategies to gain access to the left-ventricle (atrial transseptal or ventricular transseptal access) or alternative right-ventricular (septal, His bundle pacing) pacing sites, and "leadless" LV pacing have the potential to increase response to device-based heart-failure treatment...
June 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29951804/novel-ecg-based-scoring-tool-for-prediction-of-takotsubo-syndrome
#17
Natig Gassanov, Minh Tam Le, Evren Caglayan, Martin Hellmich, Erland Erdmann, Fikret Er
BACKGROUND: Takotsubo syndrome (TS) usually involves ECG changes mimicking acute myocardial infarction (AMI). The differentiation of both disorders is crucial for selection of appropriate treatment. The aim of this study was to assess ECG parameters in patients with TS and AMI, and try to establish a scoring tool for TS prediction. METHODS: The study consisted of two study parts: evaluation and validation cohorts. Overall, the study included 82 patients with TS and 141 subjects with AMI...
June 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29951803/polymer-free-drug-coated-coronary-stents-in-diabetic-patients-at-high-bleeding-risk-a-pre-specified-sub-study-of-the-leaders-free-trial
#18
Gert Richardt, Luc Maillard, Marco Stefano Nazzaro, Mohamed Abdel-Wahab, Didier Carrié, Andres Iñiguez, Philippe Garot, Mohammed Abdellaoui, Marie-Claude Morice, David Foley, Samuel Copt, Hans-Peter Stoll, Philip Urban
OBJECTIVE: Diabetics are at increased risk after stent implantation and potentially sensitive to the type of stent and dual anti-platelet therapy (DAPT). The randomized, double-blind LEADERS FREE trial compared 2432 patients at high bleeding risk (HBR) receiving either a polymer-free BA9-coated stent (DCS) or a bare metal stent (BMS) with 1 month of DAPT, and showed superior safety and efficacy of the DCS at 2 years. We report outcomes at 2 years of the pre-specified diabetic subgroup...
June 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29951802/body-mass-index-and-all-cause-mortality-in-heart-failure-patients-with-normal-and-reduced-ventricular-ejection-fraction-a-dose-response-meta-analysis
#19
REVIEW
Jufen Zhang, Aine Begley, Ruth Jackson, Michael Harrison, Pierpaolo Pellicori, Andrew L Clark, John G F Cleland
BACKGROUND: For patients with heart failure, there is an inverse relation between body mass index (BMI) and mortality, sometimes called the obesity-paradox. However, the relationship might be either U- or J-shaped and might differ between patients with reduced (HFrEF) or preserved left ventricular ejection fraction (HFpEF). We sought to investigate this further in a dose-response meta-analysis of published studies. METHODS: PubMed and Embase from June 1980 to April 2017 were searched for prospective cohort studies evaluating associations between BMI and all-cause mortality in patients with HFrEF (LVEF < 40%) or HFpEF (LVEF ≥ 50%)...
June 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29951801/transcatheter-aortic-valve-implantation-in-germany
#20
REVIEW
Won-Keun Kim, Christian W Hamm
Over the past years, there has been a tremendous evolution of transcatheter aortic valve implantation (TAVI) that turned a novel revolutionary approach to a mature concept. Peri-procedural complications and mortality rates have markedly decreased; hence, TAVI became an integral component of the treatment strategy for patients with severe aortic stenosis and now is the preferred therapy in elderly patients with moderate to high or prohibitive operative risk. This successful development would not have been possible without the joint efforts of clinicians, scientists, engineers, and many others from around the world...
June 27, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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