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Clinical Research in Cardiology: Official Journal of the German Cardiac Society

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https://www.readbyqxmd.com/read/28093621/outcome-of-elderly-undergoing-extracorporeal-life-support-in-refractory-cardiogenic-shock
#1
Suzanne de Waha, Tobias Graf, Steffen Desch, Georg Fuernau, Ingo Eitel, Janine Pöss, Alexander Jobs, Thomas Stiermaier, Jakob Ledwoch, Ariane Wiedau, Philipp Lurz, Gerhard Schuler, Holger Thiele
BACKGROUND: The current study presents data from a real-world cohort of patients with refractory cardiogenic shock (CS) undergoing extracorporeal life support (ECLS) focusing on the comparison of elderly versus younger patients. METHODS AND RESULTS: One hundred consecutive patients with refractory CS underwent percutaneous ECLS implantation performed by interventional cardiologists. Follow-up was performed at hospital discharge as well as at a median of 18 months [interquartile range 15-36]...
January 16, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28078448/synergic-impact-of-oral-anticoagulation-control-and-renal-function-in-determining-major-adverse-events-in-atrial-fibrillation-patients-undergoing-percutaneous-coronary-intervention-insights-from-the-afcas-registry
#2
Marco Proietti, K E Juhani Airaksinen, Andrea Rubboli, Axel Schlitt, Tuomas Kiviniemi, Pasi P Karjalainen, Gregory Y H Lip
BACKGROUND: In patients with atrial fibrillation (AF), quality of oral anticoagulation control as well as impaired renal function are associated with adverse outcomes. Our objective was to analyze if there was a synergistic impact of these factors in determining adverse outcomes in AF patients undergoing percutaneous coronary intervention and stent (PCI-S). METHODS: Post-hoc analysis from the Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28078447/trends-in-aortic-valve-replacement-in-germany-in-2015-transcatheter-versus-isolated-surgical-aortic-valve-repair
#3
Luise Gaede, Johannes Blumenstein, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Holger Nef, Christian Hamm, Albrecht Elsässer, Helge Möllmann
AIMS: We analysed the number of procedures, indications, and in-hospital mortality rates of all patients undergoing isolated surgical aortic valve replacement (sAVR) or transvascular (TV-) and transapical (TA-) transcatheter aortic valve implantation (TAVI) from 2012 to 2015 in Germany. METHODS AND RESULTS: More than 31,000 aortic valve procedures were performed in 2015 in Germany, representing a total increase of 4.5% over 2014. TV-TAVI accounts for 13,108 of these procedures, with an increase of 21%, whereas the numbers of isolated sAVR and TA-TAVI decreased slightly...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28005170/improv-ed-study-outcomes-after-discharge-for-an-episode-of-acute-decompensated-heart-failure-and-comparison-between-patients-discharged-from-the-emergency-department-and-hospital-wards
#4
Òscar Miró, Víctor Gil, Carolina Xipell, Carolina Sánchez, Sira Aguiló, Francisco J Martín-Sánchez, Pablo Herrero, Javier Jacob, Alexandre Mebazaa, Veli-Pekka Harjola, Pere Llorens
OBJECTIVE: To define the short- and mid-term outcomes of patients discharged after an episode of acute-decompensated heart failure (ADHF) and evaluate the differences between patients discharged directly from the emergency department (ED) and those discharged after hospitalization. METHODS: We performed a prospective, multicenter, cohort-designed study, including consecutive patients diagnosed with ADHF in 27 Spanish EDs. Thirty-four variables on epidemiology, comorbidity, baseline status, vital signs, signs of congestion, laboratory tests, and treatment were collected in every patient...
December 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28004184/midregional-proadrenomedullin-and-growth-differentiation-factor-15-are-not-influenced-by-obesity-in-heart-failure-patients
#5
Christoph Sinning, Francisco Ojeda, Philipp S Wild, Renate B Schnabel, Michael Schwarzl, Sevenai Ohdah, Karl J Lackner, Norbert Pfeiffer, Matthias Michal, Maria Blettner, Thomas Munzel, Tibor Kempf, Kai C Wollert, Kari Kuulasmaa, Stefan Blankenberg, Veikko Salomaa, Dirk Westermann, Tanja Zeller
BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m(2)) and 107 individuals with HF...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28004183/hydroxychloroquine-induced-cardiomyopathy-in-a-patient-with-limited-cutaneous-systemic-sclerosis
#6
LETTER
Amr Abdin, Janine Pöss, Reinhard Kandolf, Holger Thiele
No abstract text is available yet for this article.
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27999930/impact-of-baseline-tricuspid-regurgitation-on-long-term-clinical-outcomes-and-survival-after-interventional-edge-to-edge-repair-for-mitral-regurgitation
#7
Robert Schueler, Can Öztürk, Jan-Malte Sinning, Nikos Werner, Armin Welz, Christoph Hammerstingl, Georg Nickenig
AIMS: Tricuspid regurgitation (TR) in patients with mitral valve disease is associated with poor outcome and mortality. Only limited data on the impact of TR on functional outcome and survival in patients undergoing MitraClip procedures are available. METHODS AND RESULTS: 261 patients (mean age 76.6 ± 10, EuroScore 15.9 ± 15.1%) with symptomatic mitral regurgitation (MR) (75.2% functional MR) undergoing MitraClip procedure were included and followed for 721 ± 19...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27999929/acute-heart-failure-with-mid-range-left-ventricular-ejection-fraction-clinical-profile-in-hospital-management-and-short-term-outcome
#8
Dimitrios Farmakis, Panagiotis Simitsis, Vasiliki Bistola, Filippos Triposkiadis, Ignatios Ikonomidis, Spyridon Katsanos, George Bakosis, Erifili Hatziagelaki, John Lekakis, Alexandre Mebazaa, John Parissis
BACKGROUND: Heart failure with mid-range left ventricular ejection fraction (HFmrEF) is a poorly characterized population as it has been studied either in the context of HF with reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction (LVEF) depending on applied LVEF cutoffs. We sought to investigate the clinical profile, in-hospital management, and short-term outcome of HFmrEF patients in comparison with those with HFrEF or HFpEF in a large acute HF cohort. METHODS AND RESULTS: The Acute Heart Failure Global Registry of Standard Treatment (ALARM-HF) included 4953 patients hospitalized for HF in nine countries in Europe, Latin America, and Australia...
December 20, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27995320/thrombosis-of-tavi-prosthesis-cause-for-concern-or-innocent-bystander-a-comment-and-review-of-currently-available-data
#9
EDITORIAL
Stephan H Schirmer, Felix Mahfoud, Peter Fries, Bruno Scheller
No abstract text is available yet for this article.
December 19, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27957627/blood-pressure-response-to-catheter-based-renal-sympathetic-denervation-in-severe-resistant-hypertension-data-from-the-greek-renal-denervation-registry
#10
C Tsioufis, A Ziakas, K Dimitriadis, P Davlouros, M Marketou, A Kasiakogias, C Thomopoulos, D Petroglou, D Tsiachris, M Doumas, E Skalidas, C Karvounis, D Alexopoulos, P Vardas, I Kallikazaros, C Stefanadis, V Papademetriou, D Tousoulis
BACKGROUND/INTRODUCTION: The efficacy of catheter-based renal sympathetic denervation (RDN) in terms of blood pressure (BP) reduction has been questioned, while "real-world" data from registries are needed. In this study, we report the complete set of 12-month data on office and ambulatory BP changes as well as the predictors for BP response to RDN from a national registry. METHODS: In 4 Greek hospital centers, 79 patients with severe drug-resistant hypertension (age 59 ± 10 years, 53 males, body mass index 33 ± 5 kg/m(2); office BP and 24-h ambulatory BP were 176 ± 15/95 ± 13 and 155 ± 14/90 ± 12 mmHg, respectively, 4...
December 12, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27933393/prevalence-and-prognostic-impact-of-left-sided-valve-thickening-in-systemic-light-chain-amyloidosis
#11
Dania Mohty, Sarah Pradel, Julien Magne, Bahaa Fadel, Cyrille Boulogne, Vincent Petitalot, Safaa Raboukhi, Nicole Darodes, Thibaud Damy, Victor Aboyans, Arnaud Jaccard
BACKGROUND: Left heart valve thickening (LVT) was described in patients with light-chain amyloidosis (AL). This phenomenon reflects likely infiltration of the valve by amyloid proteins. However, the prevalence of LVT and its prognostic value have not been investigated in patients with AL. METHODS AND RESULTS: Comprehensive transthoracic echocardiography was performed at baseline in 150 patients [median age 68 (33-87) years; 59% male] with confirmed AL. The presence of abnormal mitral and/or aortic valve thickening (>3 mm) was assessed in all included patients...
December 8, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27928583/incidence-laboratory-detection-and-prognostic-relevance-of-hypoxic-hepatitis-in-cardiogenic-shock
#12
Christian Jung, Georg Fuernau, Ingo Eitel, Steffen Desch, Gerhard Schuler, Malte Kelm, Volker Adams, Holger Thiele
BACKGROUND: Despite the improvement of therapeutic options for patients in acute myocardial infarction (AMI), cardiogenic shock (CS) remains a complication with high mortality rates. Organ failure centrally determines the prognosis of these high-risk patients. Aim of the current study was to assess the incidence of hypoxic hepatitis (HH) in CS, its laboratory detection evaluating novel and established biomarkers and to estimate the prognostic relevance of HH in current clinical practice...
December 8, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27896422/transcatheter-aortic-matryoshka-doll-thrombosis
#13
LETTER
Levent Cerit
No abstract text is available yet for this article.
November 28, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27888304/the-wearable-cardioverter-defibrillator-in-a-real-world-clinical-setting-experience-in-102-consecutive-patients
#14
Julia W Erath, Mate Vamos, Abdul Sami Sirat, Stefan H Hohnloser
BACKGROUND: The wearable cardioverter-defibrillator (WCD) is used for temporary protection of patients deemed to be at high risk for sudden death (SCD) not yet meeting indications for the implantable defibrillator (ICD). OBJECTIVES: To evaluate the efficacy, safety, and compliance of/to WCD use and subsequent medium-term outcome of patients in a single-center observational study. METHODS: A total of 102 consecutive patients were fitted with the WCD from 2012 to 2015 and followed for a mean of 11 months (±8 months)...
November 25, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27878381/posttraumatic-stress-and-quality-of-life-with-the-totally-subcutaneous-compared-to-conventional-cardioverter-defibrillator-systems
#15
Julia Köbe, Katharina Hucklenbroich, Nils Geisendörfer, Markus Bettin, Gerrit Frommeyer, Florian Reinke, Dirk Dechering, Markus Burgmer, Lars Eckardt
BACKGROUND: For prevention of sudden cardiac death, the transvenously implantable cardioverter-defibrillator therapy (tv-ICD) is well accepted. The subcutaneous system (S-ICD(®)) is promising in terms of reducing ICD complications. Nevertheless, the impact of the novel generator position on patients' quality of life (QoL) is yet unknown. OBJECTIVE: This study aimed at comparing QoL and posttraumatic stress with both systems. METHODS: 60 S-ICD(®) and 60 case-controlled tv single-chamber ICD patients were asked to respond to three standardized questionnaires...
November 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27853943/endocardial-voltage-mapping-of-pulmonary-veins-with-an-ultra-high-resolution-system-to-evaluate-atrial-myocardial-extensions
#16
Francesco Santoro, Christian Sohns, Ardan M Saguner, Natale Daniele Brunetti, Christine Lemes, Shibu Mathew, Christian-H Heeger, Bruno Reißmann, Tilman Maurer, Johannes Riedl, Thomas Fink, Kentaro Hayashi, Feifan Ouyang, Matteo Di Biase, Karl-Heinz Kuck, Andreas Metzner
INTRODUCTION: Atrial fibrillation (AF) is mainly triggered by arrhythmogenic foci originating from atrial myocardial extensions (MEs) into the pulmonary veins (PVs). Aim of the study was to evaluate endocardial voltage maps of PVs as a surrogate parameter for the extent of MEs in subjects with AF through a ultra-high-density mapping system. METHODS: Sixty-four bipolar electrograms were recorded simultaneously from the Orion mini-basket catheter placed in 72 PVs of 18 consecutive patients with paroxysmal/persistent AF undergoing PV isolation (PVI)...
November 16, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27853942/course-of-early-subclinical-leaflet-thrombosis-after-transcatheter-aortic-valve-implantation-with-or-without-oral-anticoagulation
#17
Philipp Ruile, Nikolaus Jander, Philipp Blanke, Simon Schoechlin, Jochen Reinöhl, Michael Gick, Juergen Rothe, Mathias Langer, Jonathon Leipsic, Heinz-Joachim Buettner, Franz-Josef Neumann, Gregor Pache
BACKGROUND: After transcatheter aortic valve implantation, early leaflet thickening, presumably reflecting thrombus, has recently been described on computed tomography angiography (CTA) in ~10% of the patients. We sought to investigate the impact of the antithrombotic regimen on the course of leaflet thickening. METHODS: The study comprised 51 patients with leaflet thickening. Based on the time period, patients without an established indication for anticoagulation were put on phenprocoumon plus clopidogrel for at least 3 months or on dual antiplatelet therapy with aspirin and clopidogrel...
November 16, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27838739/sex-differences-in-early-dyspnea-relief-between-men-and-women-hospitalized-for-acute-heart-failure-insights-from-the-relax-ahf-study
#18
Sven Meyer, John R Teerlink, Marco Metra, Piotr Ponikowski, Gad Cotter, Beth A Davison, G Michael Felker, Gerasimos Filippatos, Barry H Greenberg, Tsushung A Hua, Thomas Severin, Min Qian, Adriaan A Voors
AIMS: Women with heart failure are typically older, and more often have hypertension and a preserved left ventricular ejection fraction as compared with men. We sought to analyze if these sex differences influence the course and outcome of acute heart failure. METHODS AND RESULTS: We analyzed sex differences in acute heart failure in 1161 patients enrolled in the RELAX-AHF study. The pre-specified study endpoints were used. At baseline, women (436/1161 patients) were older, had a higher left ventricular ejection fraction, a higher rate of hypertension, and were treated differently from men...
November 12, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27832336/comprehensive-endovascular-treatment-of-multiple-arterial-emboli-involving-lima-graft-distal-aorta-and-upper-and-lower-extremities-in-a-patient-with-subacute-cerebral-hemorrhage
#19
LETTER
Nicolas Langwieser, Karl-Ludwig Laugwitz, Tareq Ibrahim
No abstract text is available yet for this article.
November 10, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27815638/response-to-prof-dr-med-gunther-wiesner-prof-dr-med-peter-tassani-prell-and-dr-patrick-mayr-deep-sedation-versus-general-anaesthesia-in-percutaneous-edge-to-edge-mitral-valve-reconstruction-using-the-mitraclip-system
#20
LETTER
Suzanne de Waha, Steffen Desch, Ingo Eitel, Holger Thiele
No abstract text is available yet for this article.
November 4, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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