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Clinical Research in Cardiology: Official Journal of the German Cardiac Society

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https://www.readbyqxmd.com/read/28213711/implantable-cardioverter-defibrillators-for-primary-prevention-in-dilated-cardiomyopathy-post-danish-an-updated-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#1
Georg Wolff, Yingfeng Lin, Athanasios Karathanos, Maximilian Brockmeyer, Susanne Wolters, Bernd Nowak, Alexander Fürnkranz, Hisaki Makimoto, Malte Kelm, Volker Schulze
BACKGROUND: Sudden cardiac death (SCD) is frequent in patients with heart failure due to dilated cardiomyopathy (DCM). Implantable cardioverter/defibrillator (ICD) device therapy is currently used for primary prevention. However, publication of the DANISH trial has recently given reason for doubt, showing no significant improvement in all-cause mortality in comparison to contemporary medical therapy. METHODS: We performed a meta-analysis of all randomized controlled trials comparing ICD therapy to medical therapy (MT) for primary prevention in DCM...
February 17, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28204965/prognostic-value-of-simple-frailty-and-malnutrition-screening-tools-in-patients-with-acute-heart-failure-due-to-left-ventricular-systolic-dysfunction
#2
S Sze, J Zhang, P Pellicori, D Morgan, A Hoye, A L Clark
BACKGROUND: Frailty and malnutrition are common in patients with heart failure (HF), and are associated with adverse outcomes. We studied the prognostic value of three malnutrition and three frailty indices in patients admitted acutely to hospital with HF. METHODS: 265 consecutive patients [62% males, median age 80 (interquartile range (IQR): 72-86) years, median NTproBNP 3633 (IQR: 2025-6407) ng/l] admitted with HF between 2013 and 2014 were enrolled. Patients were screened for frailty using the Derby frailty index (DFI), acute frailty network (AFN) frailty criteria, and clinical frailty scale (CFS) and for malnutrition using the geriatric nutritional risk index (GNRI), controlling nutritional status (CONUT) score and prognostic nutritional index (PNI)...
February 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28204964/first-in-man%C3%A2-and-wife-transcatheter-aortic-valve-implantation-for-an-octogenarian-diamond-couple-performed-on-the-same-day
#3
LETTER
Antonio H Frangieh, Markus Klos, Jonathan Michel, Heribert Schunkert, Albert Markus Kasel
No abstract text is available yet for this article.
February 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28194496/impact-of-pulmonary-hypertension-on-outcome-in-patients-with-severe-aortic-stenosis-and-preserved-left-ventricular-ejection-fraction
#4
Julien Magne, Dania Mohty, Alessandro Piccardo, Cyrille Boulogne, Mathieu Deltreuil, Vincent Petitalot, Najmeddine Echahidi, Nicole Darodes, Patrice Virot, Thibaud Damy, Victor Aboyans
AIMS: The prognostic impact of elevated pulmonary arterial pressure (PAP) remains controversial in aortic stenosis (AS) and few studies focused on patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the impact of pulmonary hypertension (PH), invasively derived, on survival in severe AS with preserved LVEF. METHODS AND RESULTS: Between 2000 and 2010, 749 patients (74 ± 8 years, 57% males) with preserved LVEF and severe AS without other valvular heart disease underwent cardiac catheterization...
February 14, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28180940/in-stent-restenosis-after-interventional-treatment-of-carotid-artery-stenoses-a-long-term-follow-up-of-a-single-center-cohort
#5
J Kammler, H Blessberger, T Lambert, J Kellermair, M Grund, A Nahler, M Lichtenauer, S Schwarz, C Reiter, C Steinwender, A Kypta
BACKGROUND: Whereas in-stent restenosis (ISR) is widely discussed after coronary stenting procedures, this phenomenon is a considerable problem after interventional treatment of carotid artery stenosis as well. We sought to quantify ISR rate and to identify important respective risk factors in our cohort. METHODS: We retrospectively analyzed data of our carotid artery stenting database comprising 1165 angiographically successful interventional procedures during the last 19 years...
February 8, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28180939/coronary-steal-syndrome-after-left-internal-mammary-bypass-in-a-patient-with-undiagnosed-takayasu-arteritis
#6
LETTER
Pascal Bauer, Astrid Kerstin Most, Christian W Hamm, Dursun Gündüz
No abstract text is available yet for this article.
February 8, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28168514/limits-of-the-possible-diagnostic-image-quality-in-coronary-angiography-with-third-generation-dual-source-ct
#7
Marco M Ochs, Fabian Aus dem Siepen, Thomas Fritz, Florian Andre, Gitsios Gitsioudis, Grigorios Korosoglou, Sebastian Seitz, Yuriy Bogomazov, Christopher L Schlett, Roman Sokiranski, Andre Sommer, Friedemann Gückel, Matthias Brado, Hans-Ulrich Kauczor, Johannes Görich, Matthias G W Friedrich, Hugo A Katus, Sebastian J Buss
BACKGROUND: The usage of coronary CT angiography (CTA) is appropriate in patients with acute or chronic chest pain; however the diagnostic accuracy may be challenged with increased Agatston score (AS), increased heart rate, arrhythmia and severe obesity. Thus, we aim to determine the potential of the recently introduced third-generation dual-source CT (DSCT) for CTA in a 'real-life' clinical setting. METHODS: Two hundred and sixty-eight consecutive patients (age: 67 ± 10 years; BMI: 27 ± 5 kg/m²; 61% male) undergoing clinically indicated CTA with DSCT were included in the retrospective single-center analysis...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28168513/drop-out-from-cardiovascular-magnetic-resonance-in-a-randomized-controlled-trial-of-st-elevation-myocardial-infarction-does-not-cause-selection-bias-on-endpoints
#8
Peter Nørkjær Laursen, L Holmvang, H Kelbæk, N Vejlstrup, T Engstrøm, J Lønborg
BACKGROUND: The extent of selection bias due to drop-out in clinical trials of ST-elevation myocardial infarction (STEMI) using cardiovascular magnetic resonance (CMR) as surrogate endpoints is unknown. We sought to interrogate the characteristics and prognosis of patients who dropped out before acute CMR assessment compared to CMR-participants in a previously published double-blinded, placebo-controlled all-comer trial with CMR outcome as the primary endpoint. METHODS: Baseline characteristics and composite endpoint of all-cause mortality, heart failure and re-infarction after 30 days and 5 years of follow-up were assessed and compared between CMR-drop-outs and CMR-participants using the trial screening log and the Eastern Danish Heart Registry...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28168512/automated-oscillometric-blood-pressure-and-pulse-wave-acquisition-for-evaluation-of-vascular-stiffness-in-atherosclerosis
#9
Alexander Massmann, Jennifer Stemler, Peter Fries, Reinhard Kubale, Lutz Erwin Kraushaar, Arno Buecker
OBJECTIVE: Evaluation of diagnostic accuracy of an oscillometry-based device (VascAssist) combining fully automated ankle-brachial index (ABI) and pulse-wave velocity (PWV) assessment for detection of peripheral arterial disease (PAD). SUBJECTS AND METHODS: 110 consecutive subjects including symptomatic PAD patients (n = 41) and healthy PAD-free participants (n = 69) were recruited. All subjects underwent standard manual Doppler-based ABI (sABI) and oscillometry-based automated ABI (aABI) measurements (VascAssist)...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28150186/serelaxin-in-acute-heart-failure-patients-with-and-without-atrial-fibrillation-a-secondary-analysis-of-the-relax-ahf-trial
#10
Gerasimos Filippatos, Dimitrios Farmakis, Marco Metra, Gad Cotter, Beth A Davison, G Michael Felker, Barry H Greenberg, Tsushung A Hua, Peter S Pang, Piotr Ponikowski, Min Qian, Thomas A Severin, Adriaan A Voors, John R Teerlink
BACKGROUND: Atrial fibrillation (AFib) is a common comorbidity in HF and affects patients' outcome. We sought to assess the effects of serelaxin in patients with and without AFib. METHODS: In a post hoc analysis of the RELAX-AHF trial, we compared the effects of serelaxin on efficacy end points, safety end points and biomarkers in 1161 patients with and without AFib on admission electrocardiogram. RESULTS: AFib was present in 41.3% of patients...
February 1, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28150185/early-diagnosis-of-acute-myocardial-infarction-in-patients-with-mild-elevations-of-cardiac-troponin
#11
Jasper Boeddinghaus, Tobias Reichlin, Thomas Nestelberger, Raphael Twerenbold, Yvette Meili, Karin Wildi, Petra Hillinger, Maria Rubini Giménez, Janosch Cupa, Lukas Schumacher, Marie Schubera, Patrick Badertscher, Sydney Corbière, Karin Grimm, Christian Puelacher, Zaid Sabti, Dayana Flores Widmer, Nicolas Schaerli, Nikola Kozhuharov, Samyut Shrestha, Tobias Bürge, Patrick Mächler, Michael Büchi, Katharina Rentsch, Òscar Miró, Beatriz López, F Javier Martin-Sanchez, Esther Rodriguez-Adrada, Beata Morawiec, Damian Kawecki, Eva Ganovská, Jiri Parenica, Jens Lohrmann, Andreas Buser, Dagmar I Keller, Stefan Osswald, Christian Mueller
BACKGROUND: The early diagnosis of acute myocardial infarction (AMI) in patients with mild elevations of high-sensitivity cardiac troponin (hs-cTn) is a challenge. It is unclear whether copeptin, a marker of endogenous stress, or 1h-hs-cTn changes are better suited to address this important unmet clinical need. METHODS: We prospectively enrolled patients presenting with symptoms suggestive of AMI to the emergency department (ED). Two independent cardiologists adjudicated the final diagnosis...
February 1, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28130597/transcatheter-closure-of-a-giant-right-subclavian-artery-aneurysm
#12
LETTER
Yang Lu, Pan Li, Jian Na, Xianxian Zhao
No abstract text is available yet for this article.
January 27, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28124099/evidence-based-goals-in-ldl-c-reduction
#13
REVIEW
Handrean Soran, Ricardo Dent, Paul Durrington
The evidence from trials of statin therapy suggests that benefits in cardiovascular disease (CVD) event reduction are proportional to the magnitude of low-density lipoprotein cholesterol (LDL-C) lowering. The lack of a threshold at which LDL-C lowering is not beneficial, in terms of CVD prevention observed in these trials, is supported by epidemiological and genetic studies reporting the cardio-protective effects of lifelong low exposure to atherogenic cholesterol in a graded fashion. Providing that intensive LDL-C lowering is safe, these observations suggest that many individuals even at current LDL-C treatment targets could benefit...
January 25, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28116497/unusual-case-of-attr-amyloidosis-with-cardiac-manifestation-and-situs-inversus-totalis
#14
LETTER
Max Fritschka, Michael Schlegl, Adrian Borges, Mathias Werner, Rolf Gebker, Burkert Pieske, Sebastian Kelle
No abstract text is available yet for this article.
January 23, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28093621/outcome-of-elderly-undergoing-extracorporeal-life-support-in-refractory-cardiogenic-shock
#15
Suzanne de Waha, Tobias Graf, Steffen Desch, Georg Fuernau, Ingo Eitel, Janine Pöss, Alexander Jobs, Thomas Stiermaier, Jakob Ledwoch, Ariane Wiedau, Philipp Lurz, Gerhard Schuler, Holger Thiele
BACKGROUND: The current study presents data from a real-world cohort of patients with refractory cardiogenic shock (CS) undergoing extracorporeal life support (ECLS) focusing on the comparison of elderly versus younger patients. METHODS AND RESULTS: One hundred consecutive patients with refractory CS underwent percutaneous ECLS implantation performed by interventional cardiologists. Follow-up was performed at hospital discharge as well as at a median of 18 months [interquartile range 15-36]...
January 16, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28078448/synergic-impact-of-oral-anticoagulation-control-and-renal-function-in-determining-major-adverse-events-in-atrial-fibrillation-patients-undergoing-percutaneous-coronary-intervention-insights-from-the-afcas-registry
#16
Marco Proietti, K E Juhani Airaksinen, Andrea Rubboli, Axel Schlitt, Tuomas Kiviniemi, Pasi P Karjalainen, Gregory Y H Lip
BACKGROUND: In patients with atrial fibrillation (AF), quality of oral anticoagulation control as well as impaired renal function are associated with adverse outcomes. Our objective was to analyze if there was a synergistic impact of these factors in determining adverse outcomes in AF patients undergoing percutaneous coronary intervention and stent (PCI-S). METHODS: Post-hoc analysis from the Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28078447/trends-in-aortic-valve-replacement-in-germany-in-2015-transcatheter-versus-isolated-surgical-aortic-valve-repair
#17
Luise Gaede, Johannes Blumenstein, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Holger Nef, Christian Hamm, Albrecht Elsässer, Helge Möllmann
AIMS: We analysed the number of procedures, indications, and in-hospital mortality rates of all patients undergoing isolated surgical aortic valve replacement (sAVR) or transvascular (TV-) and transapical (TA-) transcatheter aortic valve implantation (TAVI) from 2012 to 2015 in Germany. METHODS AND RESULTS: More than 31,000 aortic valve procedures were performed in 2015 in Germany, representing a total increase of 4.5% over 2014. TV-TAVI accounts for 13,108 of these procedures, with an increase of 21%, whereas the numbers of isolated sAVR and TA-TAVI decreased slightly...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28005170/improv-ed-study-outcomes-after-discharge-for-an-episode-of-acute-decompensated-heart-failure-and-comparison-between-patients-discharged-from-the-emergency-department-and-hospital-wards
#18
Òscar Miró, Víctor Gil, Carolina Xipell, Carolina Sánchez, Sira Aguiló, Francisco J Martín-Sánchez, Pablo Herrero, Javier Jacob, Alexandre Mebazaa, Veli-Pekka Harjola, Pere Llorens
OBJECTIVE: To define the short- and mid-term outcomes of patients discharged after an episode of acute-decompensated heart failure (ADHF) and evaluate the differences between patients discharged directly from the emergency department (ED) and those discharged after hospitalization. METHODS: We performed a prospective, multicenter, cohort-designed study, including consecutive patients diagnosed with ADHF in 27 Spanish EDs. Thirty-four variables on epidemiology, comorbidity, baseline status, vital signs, signs of congestion, laboratory tests, and treatment were collected in every patient...
December 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28004184/midregional-proadrenomedullin-and-growth-differentiation-factor-15-are-not-influenced-by-obesity-in-heart-failure-patients
#19
Christoph Sinning, Francisco Ojeda, Philipp S Wild, Renate B Schnabel, Michael Schwarzl, Sevenai Ohdah, Karl J Lackner, Norbert Pfeiffer, Matthias Michal, Maria Blettner, Thomas Munzel, Tibor Kempf, Kai C Wollert, Kari Kuulasmaa, Stefan Blankenberg, Veikko Salomaa, Dirk Westermann, Tanja Zeller
BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m(2)) and 107 individuals with HF...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28004183/hydroxychloroquine-induced-cardiomyopathy-in-a-patient-with-limited-cutaneous-systemic-sclerosis
#20
LETTER
Amr Abdin, Janine Pöss, Reinhard Kandolf, Holger Thiele
No abstract text is available yet for this article.
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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