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Clinical Research in Cardiology: Official Journal of the German Cardiac Society

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https://www.readbyqxmd.com/read/29143161/point-of-care-b-type-natriuretic-peptide-and-portable-echocardiography-for-assessment-of-patients-with-suspected-heart-failure-in-primary-care-rationale-and-design-of-the-three-part-handheld-bnp-program-and-results-of-the-training-study
#1
Caroline Morbach, Thomas Buck, Christian Rost, Sebastian Peter, Stephan Günther, Stefan Störk, Christiane Prettin, Raimund Erbel, Georg Ertl, Christiane E Angermann
BACKGROUND: Patients with suspected heart failure (HF) often present first to general practitioners (GPs). Timely and accurate HF diagnosis and reliable prognostic information have remained unmet goals in primary care, where patient evaluation often relies on clinical assessment only. The Handheld-BNP program investigates whether additional use of portable echocardiography (ECHO) and point-of-care determination of B-type natriuretic peptide (BNP) improves the accuracy of HF diagnosis and aids risk prediction in primary care...
November 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29134346/outcomes-after-percutaneous-coronary-intervention-for-chronic-total-occlusion-according-to-baseline-renal-function
#2
Barbara E Stähli, Cathérine Gebhard, Michael Gick, Miroslaw Ferenc, Kambis Mashayekhi, Heinz Joachim Buettner, Franz-Josef Neumann, Aurel Toma
BACKGROUND: Chronic kidney disease (CKD) adversely affects outcomes in patients with coronary artery disease. Data on the impact of renal impairment on prognosis of patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are scarce. METHODS: A total of 2002 patients undergoing CTO PCI were stratified according to baseline renal function (group 1: estimated glomerular filtration rate [eGFR] ≥ 90 ml/min/1.73 m(2), group 2: 60 to 89 ml/min/1...
November 13, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29134345/trends-in-mechanical-circulatory-support-use-and-hospital-mortality-among-patients-with-acute-myocardial-infarction-and-non-infarction-related-cardiogenic-shock-in-the-united-states
#3
Mahek Shah, Soumya Patnaik, Brijesh Patel, Pradhum Ram, Lohit Garg, Manyoo Agarwal, Sahil Agrawal, Shilpkumar Arora, Nilay Patel, Joyce Wald, Ulrich P Jorde
BACKGROUND: Recent trends on outcomes in cardiogenic shock (CS) complicating acute myocardial infarction (AMI) suggest improvements in early survival. However, with the ever-changing landscape in management of CS, we sought to identify age-based trends in these outcomes and mechanical circulatory support (MCS) use among patients with both AMI and non-AMI associated shock. METHODS: We queried the 2005-2014 Nationwide Inpatient Sample databases to identify patients with a diagnosis of cardiogenic shock...
November 13, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29127472/prognostic-impact-of-atrial-fibrillation-in-cardiogenic-shock-complicating-acute-myocardial-infarction-a-substudy-of-the-iabp-shock-ii-trial
#4
Suzanne de Waha, Katharina Schoene, Georg Fuernau, Steffen Desch, Ingo Eitel, Janine Pöss, Roza Meyer-Saraei, Charlotte Eitel, Roland Tilz, Gerhard Schuler, Karl Werdan, Steffen Schneider, Taoufik Ouarrak, Uwe Zeymer, Holger Thiele
BACKGROUND: Aim of the current study was to analyse the impact of atrial fibrillation (AF) on prognosis in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI), which has never been investigated yet. METHODS: The current analysis is a substudy of the IABP-SHOCK II trial. Patients were grouped according to the presence or absence of AF. The primary endpoint was all-cause mortality at 30-day follow-up. Secondary endpoints included all-cause mortality, recurrent myocardial infarction, repeat revascularisation, and stroke at 12 months...
November 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29101459/symmetric-dimethylarginine-sdma-outperforms-asymmetric-dimethylarginine-adma-and-other-methylarginines-as-predictor-of-renal-and-cardiovascular-outcome-in-non-dialysis-chronic-kidney-disease
#5
Insa E Emrich, Adam M Zawada, Jens Martens-Lobenhoffer, Danilo Fliser, Stefan Wagenpfeil, Gunnar H Heine, Stefanie M Bode-Böger
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of renal and cardiovascular events. It has been claimed that endogenous methylarginines, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), are contributing factors. However, earlier studies were partly contradictory and mainly focused on prevalent dialysis patients. Moreover, the potential contribution of degradation products, such as acetylated ADMA and SDMA (AcADMA and AcSDMA) and other methylarginines including L-N(G)-monomethylarginine (LNMMA) remains unknown...
November 3, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29098379/influence-of-hydrostatic-pressure-on-intracoronary-indices-of-stenosis-severity-in-vivo
#6
Tobias Härle, Mareike Luz, Sven Meyer, Felix Vahldiek, Pim van der Harst, Randy van Dijk, Daan Ties, Javier Escaned, Justin Davies, Albrecht Elsässer
BACKGROUND: An influence of hydrostatic pressure on intracoronary indices of stenosis severity in vitro was recently reported. We sought to analyze the influence of hydrostatic pressure, caused by the height difference between the distal and proximal pressure sensor after guidewire positioning in the interrogated vessel, on intracoronary pressure measurements in vivo. METHODS AND RESULTS: In 30 coronary stenoses, intracoronary pressure measurements were performed in supine, left, and right lateral patient position...
November 2, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29098378/control-of-cardiac-chronotropic-function-in-patients-after-heart-transplantation-effects-of-ivabradine-and-metoprolol-succinate-on-resting-heart-rate-in-the-denervated-heart
#7
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Ann-Kathrin Rahm, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Philipp Ehlermann, Hugo A Katus, Andreas O Doesch
BACKGROUND: Patients after heart transplantation (HTX) present with sinus tachycardia due to graft denervation. As elevated heart rates negatively affect survival, the aim of this study was to analyze the effects of ivabradine vs metoprolol succinate on heart rate, left ventricular (LV) mass and survival following HTX. METHODS: This observational retrospective single-center study assessed 84 patients continuously receiving either ivabradine (n = 40) or metoprolol succinate (n = 44) within 2 years after HTX...
November 2, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29080909/association-between-hypo-and-hyperkalemia-and-outcome-in-acute-heart-failure-patients-the-role-of-medications
#8
Matthieu Legrand, Pierre-Olivier Ludes, Ziad Massy, Patrick Rossignol, Jiri Parenica, Jin-Joo Park, Shiro Ishihara, Khalid F AlHabib, Aldo Maggioni, Òscar Miró, Naoki Sato, Alain Cohen-Solal, Enrique Fairman, Johan Lassus, Veli-Pekka Harjola, Christian Mueller, Franck W Peacock, Dong-Ju Choi, Patrick Plaisance, Jindřich Spinar, Mikhail Kosiborod, Alexandre Mebazaa, Etienne Gayat
BACKGROUND: The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown. METHODS: Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes...
October 28, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29075979/second-generation-cryoballoon-ablation-for-persistent-atrial-fibrillation-an-updated-meta-analysis
#9
Hazem Omran, Klaus-Jürgen Gutleben, Stephan Molatta, Thomas Fischbach, Birgit Wellmann, Dieter Horstkotte, Britta Körber, Georg Nölker
BACKGROUND: Catheter ablation is an established treatment option for patients with symptomatic atrial fibrillation (AF). The cornerstone of AF ablation is pulmonary vein isolation (PVI). The second-generation cryoballoon (2G-CB) has shown non-inferiority to radiofrequency (RF) ablation in paroxysmal AF in several trials. Growing evidence suggests that 2G-CB is also effective in patients with persistent AF (perAF). The aim of this study was to summarize and analyze available data on safety and mid-term (≥ 12 months) efficacy of PVI using 2G-CB in patients with perAF...
October 26, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29018938/heart-failure-with-preserved-ejection-fraction-current-management-and-future-strategies-expert-opinion-on-the-behalf-of-the-nucleus-of-the-heart-failure-working-group-of-the-german-society-of-cardiology-dkg
#10
REVIEW
Carsten Tschöpe, Christoph Birner, Michael Böhm, Oliver Bruder, Stefan Frantz, Andreas Luchner, Lars Maier, Stefan Störk, Behrouz Kherad, Ulrich Laufs
About 50% of all patients suffering from heart failure (HF) exhibit a reduced ejection fraction (EF ≤ 40%), termed HFrEF. The others may be classified into HF with midrange EF (HFmrEF 40-50%) or preserved ejection fraction (HFpEF, EF ≥ 50%). Presentation and pathophysiology of HFpEF is heterogeneous and its management remains a challenge since evidence of therapeutic benefits on outcome is scarce. Up to now, there are no therapies improving survival in patients with HFpEF. Thus, the treatment targets symptom relief, quality of life and reduction of cardiac decompensations by controlling fluid retention and managing risk factors and comorbidities...
October 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28993869/lack-of-silent-cerebral-ischemic-events-a-case-series-of-patients-after-left-atrial-appendage-closure
#11
LETTER
Christian Fastner, Michael Behnes, Thomas Henzler, Martin Borggrefe, Ibrahim Akin
No abstract text is available yet for this article.
October 9, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28993851/usefulness-of-the-wcd-in-patients-with-suspected-tachymyopathy
#12
Julia W Erath, Mate Vamos, Alexander P Benz, Stefan H Hohnloser
AIMS: The wearable cardioverter defibrillator (WCD) is used for temporary protection of patients deemed to be at high risk for sudden death. There is limited experience regarding the clinical development of patients with tachymyopathy. We aimed to evaluate the clinical development of tachymyopathy patients protected with a WCD in a single-center non-randomized patient cohort. METHODS AND RESULTS: We fitted 130 consecutive patients deemed to be at high risk for ventricular tachyarrhythmias with the WCD...
October 9, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28986703/relationship-between-baseline-systolic-blood-pressure-and-long-term-outcomes-in-acute-heart-failure-patients-treated-with-trv027-an-exploratory-subgroup-analysis-of-blast-ahf
#13
Gad Cotter, Beth A Davison, Javed Butler, Sean P Collins, Justin A Ezekowitz, G Michael Felker, Gerasimos Filippatos, Phillip D Levy, Marco Metra, Piotr Ponikowski, John R Teerlink, Adriaan A Voors, Stefanie Senger, David Bharucha, Kathleen Goin, David G Soergel, Peter S Pang
INTRODUCTION: TRV027, a 'biased' ligand of the angiotensin II type 1 receptor (AT1R), did not affect a composite clinical outcome at 30 days in a phase 2b acute heart failure (AHF) trial (BLAST-AHF). METHODS: Post-hoc analyses from BLAST-AHF (n = 618) examined the effects of TRV027 by baseline systolic blood pressure (SBP) on changes in renal function and 180-day outcomes. Interactions between baseline SBP and select endpoints were identified utilizing a subpopulation treatment effect pattern plots (STEPP) analysis, then grouping of patients by SBP tertile: < 127, ≥ 127 to < 140, and ≥ 140 mmHg...
October 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28965260/the-t-peak-to-t-end-interval-a-novel-ecg-marker-for-ventricular-arrhythmia-and-appropriate-icd-therapy-in-patients-with-hypertrophic-cardiomyopathy
#14
Leon Dinshaw, Julia Münch, Jannis Dickow, Susanne Lezius, Stephan Willems, Boris A Hoffmann, Monica Patten
INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings...
September 30, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28963581/pacemaker-implantation-after-tavi-predictors-of-av-block-persistence
#15
Luise Gaede, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Johannes Sperzel, Johannes Blumenstein, Alexander Berkowitsch, Thomas Walther, Christian Hamm, Albrecht Elsässer, Holger Nef, Helge Möllmann
AIMS: Approximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. METHODS AND RESULTS: Between 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM (n = 173) 14...
September 29, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28956153/predictors-of-survival-stratification-in-patients-with-wild-type-cardiac-amyloidosis
#16
F Aus dem Siepen, R Bauer, A Voss, S Hein, M Aurich, J Riffel, D Mereles, C Röcken, S J Buss, H A Katus, Arnt V Kristen
OBJECTIVES: To analyze clinical predictors of mortality in wild-type transthyretin amyloidosis (wt-ATTR). METHODS: In total, 191 patients (73.8 ± 0.5 years; 176 males, 15 females) with histologically proven wt-ATTR amyloidosis and genetic exclusion of a transthyretin gene variant were included. Comprehensive clinical characteristics, ECG, biomarkers, and echocardiography were analyzed retrospectively. Strain analyses were performed offline using TomTec Imaging Systems, Germany...
September 27, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28942524/characteristics-of-sleep-disordered-breathing-in-patients-with-atrial-fibrillation-and-preserved-left-ventricular-ejection-fraction
#17
Johanna Strotmann, Henrik Fox, Thomas Bitter, Odile Sauzet, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Sleep-disordered breathing (SDB) represents a common and highly relevant co-morbidity in patients with atrial fibrillation (Afib). Obstructive sleep apnea (OSA) has been identified as an independent risk factor for developing Afib and for Afib recurrence after treatment, but the role of central sleep apnea (CSA) is less clear. This study investigated characteristics of SDB in Afib patients with preserved left ventricular ejection fraction (PEF). METHODS AND RESULTS: Consecutive patients (07/2007 to 03/2016) with documented Afib at hospital admission and PEF undergoing 6-channel cardiorespiratory polygraphy (PG) screening were retrospectively analyzed...
September 23, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28939956/radial-access-protects-from-contrast-media-induced-nephropathy-after-cardiac-catheterization-procedures
#18
Thorsten Feldkamp, Maya Luedemann, Martina E Spehlmann, Sandra Freitag-Wolf, Julia Gaensbacher, Kevin Schulte, Amer Bajrovic, Dieter Hinzmann, Hans-Joerg Hippe, Ulrich Kunzendorf, Norbert Frey, Mark Luedde
OBJECTIVES: To assess, whether cardiac catheterization via radial access prevents contrast-induced nephropathy. BACKGROUND: Contrast-induced nephropathy (CIN) is a major clinical problem which accounts for more than 10% of acute kidney injury cases in hospitalized patients. Protective measures such as the infusion of isotonic saline solution or acetylcysteine have not consistently been proven to prevent acute kidney injury (AKI). However, there is growing evidence that radial access for coronary angiography and coronary intervention is associated with a lower incidence of AKI compared to femoral access...
September 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28921055/implantation-meets-intervention-reopening-of-a-thrombotic-ostial-occlusion-of-coronary-sinus-by-angioplasty-achieved-improvement-of-cardiac-venous-drainage-and-allowed-transvenous-crt-implantation
#19
LETTER
Wolfgang Kranig, Johannes Amberger, Khaled Awad, Enrik Wolff, Kerstin Vahlkamp, Joachim Thale, Bernhard Küpper
No abstract text is available yet for this article.
September 18, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28921054/association-of-mineralocorticoid-receptor-antagonist-use-and-in-hospital-outcomes-in-patients-with-acute-heart-failure
#20
Vasiliki Bistola, Panagiotis Simitsis, Dimitrios Farmakis, Ignatios Ikonomidis, Georgios Bakosis, Filippos Triposkiadis, Erifili Hatziagelaki, John Lekakis, Alexandre Mebazaa, John Parissis
Mineralocorticoid receptor antagonists (MRAs) constitute a beneficial therapy in chronic heart failure, but their use in the acute heart failure (AHF) setting remains rather unexplored. To assess the effect of MRAs administered during hospitalization on in-hospital outcomes of patients with AHF, we performed a post-hoc analysis of the Acute Heart Failure Global Registry of Standard Treatment (ALARM-HF). Patients of the original study cohort (n = 4953) were categorized according to in-hospital MRA treatment status as MRA-treated (n = 1439) and untreated (n = 3514) subjects...
September 18, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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