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International Journal of Nanomedicine

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https://www.readbyqxmd.com/read/28932119/delivery-of-a-chemotherapeutic-drug-using-novel-hollow-carbon-spheres-for-esophageal-cancer-treatment
#1
Li Zhang, Mengchu Yao, Wei Yan, Xiaoning Liu, Baofei Jiang, Zhaoye Qian, Yong Gao, Xiao-Jie Lu, Xiaofei Chen, Qi-Long Wang
Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932118/fabrication-optimization-and-characterization-of-umbelliferone-%C3%AE-d-galactopyranoside-loaded-plga-nanoparticles-in-treatment-of-hepatocellular-carcinoma-in-vitro-and-in-vivo-studies
#2
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Gaurav Kaithwas, Hani Choudhry, Fahad A Al-Abbasi, Firoz Anwar, Amita Verma
Umbelliferone β-D-galactopyranoside (UFG), isolated from plants, exhibits promising inhibitory action on numerous diseases. The present research was initiated to develop a suitable delivery system for UFG with an intention to enhance its therapeutic efficacy against diethyl nitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in Wistar rats. UFG-loaded polymeric nanoparticles prepared by sonication were scrutinized for average size, drug loading capacity, zeta potential, and drug release potency in animals...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932117/multifunctional-folate-receptor-targeting-and-ph-responsive-nanocarriers-loaded-with-methotrexate-for-treatment-of-rheumatoid-arthritis
#3
Jinlong Zhao, Menghui Zhao, Changhui Yu, Xueyan Zhang, Jiaxin Liu, Xinwei Cheng, Robert J Lee, Fengying Sun, Lesheng Teng, Youxin Li
Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive cartilage and bone destruction. Activated macrophages that overexpress folic acid (FA) receptors play an important role in RA, due to their abundance in inflamed synovial membrane and joints. In an effort to deliver drugs to the inflamed tissues, multifunctional FA receptor-targeting and pH-responsive nanocarriers were developed. They were composed of lipids, polyethylene glycol (PEG)-poly(lactic-co-glycolic acid) (PLGA) forming a hydrophilic shell, FA around the hydrophilic shell as a targeting ligand, and poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK) and PLGA as a hydrophobic core...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932116/silk-fibroin-cartilage-extracellular-matrix-scaffolds-with-sequential-delivery-of-tgf-%C3%AE-3-for-chondrogenic-differentiation-of-adipose-derived-stem-cells
#4
Qiang Yang, Bin-Hong Teng, Li-Na Wang, Kun Li, Chen Xu, Xin-Long Ma, Yang Zhang, De-Ling Kong, Lian-Yong Wang, Yan-Hong Zhao
A 3-D scaffold that simulates the microenvironment in vivo for regenerating cartilage is ideal. In this study, we combined silk fibroin and decellularized cartilage extracellular matrix by temperature gradient-guided thermal-induced phase separation to produce composite scaffolds (S/D). Resulting scaffolds had remarkable mechanical properties and biomimeticstructure, for a suitable substrate for attachment and proliferation of adipose-derived stem cells (ADSCs). Moreover, transforming growth factor β3 (TGF-β3) loaded on scaffolds showed a controlled release profile and enhanced the chondrogenic differentiation of ADSCs during the 28-day culture...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932115/the-long-term-fate-of-mesenchymal-stem-cells-labeled-with-magnetic-resonance-imaging-visible-polymersomes-in-cerebral-ischemia
#5
Xiaohui Duan, Liejing Lu, Yong Wang, Fang Zhang, Jiaji Mao, Minghui Cao, Bingling Lin, Xiang Zhang, Xintao Shuai, Jun Shen
Understanding the long-term fate and potential mechanisms of mesenchymal stem cells (MSCs) after transplantation is essential for improving functional benefits of stem cell-based stroke treatment. Magnetic resonance imaging (MRI) is considered an attractive and clinically translatable tool for longitudinal tracking of stem cells, but certain controversies have arisen in this regard. In this study, we used SPION-loaded cationic polymersomes to label green fluorescent protein (GFP)-expressing MSCs to determine whether MRI can accurately reflect survival, long-term fate, and potential mechanisms of MSCs in ischemic stroke therapy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932114/spermidine-mediated-poly-lactic-co-glycolic-acid-nanoparticles-containing-fluorofenidone-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#6
Jing Tang, Jianming Li, Guo Li, Haitao Zhang, Ling Wang, Dai Li, Jinsong Ding
Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival. The advances made in deciphering this disease have led to the approval of different antifibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles (liposomes, nanoparticles [NPs], microspheres, nanopolymersomes, and nanoliposomes) modified with different functional groups have demonstrated improvement in lung-targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine (Spd)-modified poly(lactic-co-glycolic acid) (PLGA) NPs as carriers for fluorofenidone (AKF) to improve the antifibrotic efficacy of this drug in the lung...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932113/cationic-lipid-based-nanoparticles-mediate-functional-delivery-of-acetate-to-tumor-cells-in-vivo-leading-to-significant-anticancer-effects
#7
Leigh P Brody, Meliz Sahuri-Arisoylu, James R Parkinson, Harry G Parkes, Po Wah So, Nabil Hajji, E Louise Thomas, Gary S Frost, Andrew D Miller, Jimmy D Bell
Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system - liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28924349/autophagy-promotes-degradation-of-polyethyleneimine-alginate-nanoparticles-in-endothelial-progenitor-cells
#8
Guo-Dong Wang, Yu-Zhen Tan, Hai-Jie Wang, Pei Zhou
Polyethyleneimine (PEI)-alginate (Alg) nanoparticle (NP) is a safe and effective vector for delivery of siRNA or DNA. Recent studies suggest that autophagy is related to cytotoxicity of PEI NPs. However, contribution of autophagy to degradation of PEI-Alg NPs remains unknown. CD34(+)VEGFR-3(+) endothelial progenitor cells isolated from rat bone marrow were treated with 25 kDa branched PEI modified by Alg. After treatment with the NPs, morphological changes and distribution of the NPs in the cells were examined with scanning and transmission electron microscopies...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28924348/single-walled-carbon-nanotubes-ciprofloxacin-nanoantibiotic-strategy-to-improve-ciprofloxacin-antibacterial-activity
#9
Mohyeddin Assali, Abdel Naser Zaid, Farah Abdallah, Motasem Almasri, Rasha Khayyat
As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28924347/the-mechanisms-of-graphene-based-materials-induced-programmed-cell-death-a-review-of-apoptosis-autophagy-and-programmed-necrosis
#10
REVIEW
Lingling Ou, Shaoqiang Lin, Bin Song, Jia Liu, Renfa Lai, Longquan Shao
Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to the potential unexpected toxic effects of GBMs. Here, we review the recent literature regarding the impact of GBMs on programmed cell death (PCD). Apoptosis, autophagy, and programmed necrosis are three major PCDs. Mechanistic studies demonstrated that the mitochondrial pathways and MAPKs (JNK, ERK, and p38)- and TGF-β-related signaling pathways are implicated in GBMs-induced apoptosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28924346/co-delivery-of-polyinosinic-polycytidylic-acid-and-flagellin-by-poly-lactic-co-glycolic-acid-mps-synergistically-enhances-immune-response-elicited-by-intranasally-delivered-hepatitis-b-surface-antigen
#11
Xiaojing Dai, Jintian He, Ruxia Zhang, Guanghao Wu, Fangfang Xiong, Baohua Zhao
The aim of the present work was to investigate the synergistic effect between toll-like receptor (TLR) 3 ligand polyinosinic:polycytidylic acid (pI:C) and TLR5 ligand flagellin (FLN) on immune responses induced by nasally delivered hepatitis B virus surface antigen (HBsAg). Mannan and chitosan oligosaccharide-modified, pH-responsive poly(lactic-co-glycolic acid) (MC-PLGA) microparticles (MPs) containing HBsAg, FLN, pI:C or both ligands were prepared with a double-emulsion method. In vitro uptake experiments show that cellular uptake of MC-PLGA MPs by macrophages was through energy-dependent, receptor-mediated endocytosis mechanism...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28924345/delivery-of-paeonol-by-nanoparticles-enhances-its-in-vitro-and-in-vivo-antitumor-effects
#12
Cong Chen, Feng Jia, Zhibo Hou, Shu Ruan, Qibin Lu
Paeonol (Pae; 2'-hydroxy-4'-methoxyacetophenone) has attracted intense attention as a potential therapeutic agent against various cancers. However, the use of Pae is limited owing to its hydrophobicity. Recently, biodegradable polymeric nanoparticles with amphiphilic copolymers have been used as drug carriers; these have better bioavailability and are promising tumor-targeted drug delivery systems. In the current study, we prepared Pae-loaded nanoparticles (Pae-NPs) with amphiphilic block copolymers using nanoprecipitation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919756/polymeric-mixed-micelles-loaded-mitoxantrone-for-overcoming-multidrug-resistance-in-breast-cancer-via-photodynamic-therapy
#13
Zeyong Li, Yuee Cai, Yiqiao Zhao, Hua Yu, Haiyu Zhou, Meiwan Chen
Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(d,l-lactide-co-glycolide)-poly(ethylene glycol)-poly(d,l-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919755/synthetic-high-density-lipoprotein-nanodisks-for-targeted-withalongolide-delivery-to-adrenocortical-carcinoma
#14
Rui Kuai, Chitra Subramanian, Peter T White, Barbara N Timmermann, James J Moon, Mark S Cohen, Anna Schwendeman
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival rate of <35%. ACC cells require cholesterol for steroid hormone production, and this requirement is met via expression on the cell surface of a high level of SRB1, responsible for the uptake of high-density lipoproteins (HDLs), which carry and transport cholesterol in vivo. Here, we describe how this natural lipid carrier function of SRB1 can be utilized to improve the tumor-targeted delivery of a novel natural product derivative - withalongolide A 4,19,27-triacetate (WGA-TA) - which has shown potent antitumor efficacy, but poor aqueous solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919754/preparation-of-coffee-oil-algae-oil-based-nanoemulsions-and-the-study-of-their-inhibition-effect-on-uva-induced-skin-damage-in-mice-and-melanoma-cell-growth
#15
Chu-Ching Yang, Chi-Feng Hung, Bing-Huei Chen
Coffee grounds, a waste by-product generated after making coffee, contains approximately 15% coffee oil which can be used as a raw material in cosmetics. Algae oil rich in docosahexaenoic acid (DHA) has been demonstrated to possess anticancer and anti-inflammation functions. The objectives of this study were to develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of fatty acids in coffee oil and algae oil and prepare a nanoemulsion for studying its inhibition effect on ultraviolet A-induced skin damage in mice and growth of melanoma cells B16-F10...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919753/combination-of-graphene-oxide-silver-nanoparticle-nanocomposites-and-cisplatin-enhances-apoptosis-and-autophagy-in-human-cervical-cancer-cells
#16
Yu-Guo Yuan, Sangiliyandi Gurunathan
BACKGROUND: Cisplatin (Cis) is a widely used chemotherapeutic drug for treating a variety of cancers, due to its ability to induce cell death in cancer cells significantly. Recently, graphene and its modified nanocomposites have gained much interest in cancer therapy, due to their unique physicochemical properties. The objective of this study was to investigate the combination effect of Cis and a reduced graphene oxide-silver nanoparticle nanocomposite (rGO-AgNPs) in human cervical cancer (HeLa) cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919752/zinc-oxide-nanoparticles-induce-apoptosis-and-autophagy-in-human-ovarian-cancer-cells
#17
Ding-Ping Bai, Xi-Feng Zhang, Guo-Liang Zhang, Yi-Fan Huang, Sangiliyandi Gurunathan
BACKGROUND: Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products such as paint, surface coating, and cosmetics, and recently, they have been explored in biologic and biomedical applications. Therefore, this study was undertaken to investigate the effect of ZnO NPs on cytotoxicity, apoptosis, and autophagy in human ovarian cancer cells (SKOV3). METHODS: ZnO NPs with a crystalline size of 20 nm were characterized with various analytical techniques, including ultraviolet-visible spectroscopy, X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, and atomic force microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919751/combination-of-palladium-nanoparticles-and-tubastatin-a-potentiates-apoptosis-in-human-breast-cancer-cells-a-novel-therapeutic-approach-for-cancer
#18
Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
BACKGROUND: Breast cancer is the most common malignant disease that occurs in women. Histone deacetylase (HDAC) inhibition has recently emerged as an effective and attractive target for the treatment of cancer. The aim of this study was to investigate the efficacy of a combined treatment of tubastatin A (TUB-A) and palladium nanoparticles (PdNPs) against MDA-MB-231 human breast cancer cells using two different cytotoxic agents that work by two different mechanisms, thereby decreasing the probability of chemoresistance in cancer cells and increasing the efficacy of toxicity, to provide efficient therapy for advanced stage of cancer without any undesired side effects...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919750/silver-nanoparticles-enhance-the-apoptotic-potential-of-gemcitabine-in-human-ovarian-cancer-cells-combination-therapy-for-effective-cancer-treatment
#19
Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
BACKGROUND: Gemcitabine (GEM) is widely used as an anticancer agent in several types of solid tumors. Silver nanoparticles (AgNPs) possess unique cytotoxic features and can induce apoptosis in a variety of cancer cells. In this study, we investigated whether the combination of GEM and AgNPs can exert synergistic cytotoxic effects in the human ovarian cancer cell line A2780. METHODS: We synthesized AgNPs using resveratrol as a reducing and stabilizing agent. The synthesized nanomaterials were characterized using various analytical techniques...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919749/ginsenoside-rg1-nanoparticle-penetrating-the-blood-brain-barrier-to-improve-the-cerebral-function-of-diabetic-rats-complicated-with-cerebral-infarction
#20
Junyi Shen, Zhiming Zhao, Wei Shang, Chunli Liu, Beibei Zhang, Lingjie Zhao, Hui Cai
Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1) has a wide variety of therapeutic values for central nervous system (CNS) diseases for the neuron protective effects. However, the blood-brain barrier (BBB) restricts Rg1 in reaching the CNS. In this study, we investigated the therapeutic effects of Rg1 nanoparticle (PHRO, fabricated with γ-PGA, L-PAE (H), Rg1, and OX26 antibody), targeting transferrin receptor, on the diabetes rats complicated with diabetic cerebral infarction in vitro and in vivo...
2017: International Journal of Nanomedicine
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