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International Journal of Nanomedicine

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[This corrects the article on p. 6677 in vol. 13, PMID: 30425482.].
2019: International Journal of Nanomedicine
(no author information available yet)
[This corrects the article on p. 4977 in vol. 13, PMID: 30214201.].
2019: International Journal of Nanomedicine
Ying Li, Dandan Yang, Yian Wang, Zhan Li, Chunyan Zhu
Background: To establish the combination of doxorubicin (DOX) and silybin (SLB) in oral hepatic-targeting liposomes with the goal of reducing cardiotoxic side effects and improve oral hepatoma treatment. Methods: Distearoylphosphatidylethanolamine-polyethylene glycol-cholic acid-modified liposomes (CA-LP) were used to encapsulate DOX and SLB (CA-LP-DOX/SLB), and the hepatic targeting, efficacy against hepatoma and cardioprotective effects were evaluated by cell toxicity, scratch and apoptosis in vitro studies, and pharmacokinetics and pharmacodynamics in vivo studies...
2019: International Journal of Nanomedicine
Xiaoya Liu, Hui Gan, Chaoran Hu, Wenzhong Sun, Xiaoxia Zhu, Zhiyun Meng, Ruolan Gu, Zhuona Wu, Guifang Dou
Background: Silver sulfadiazine (AgSD) is widely employed as an antibacterial agent for surface burn management. However, the antibacterial activity of AgSD was restrained because of the lower drug solubility and possible cytotoxicity. Objective: This study aimed to formulate stable silver sulfadiazine/nanosuspensions (AgSD/NSs) with improved AgSD solubility and prepare a suitable carrier for AgSD/NS delivery. Nanotechnology was used to overcome the low drug dissolution rate of AgSD, while the new carrier loaded with AgSD/NS was assumed to decrease the possible cytotoxicity, enhance antibacterial activity, and promote wound healing...
2019: International Journal of Nanomedicine
Yanjun Xu, Yang Zhang, Xiaojun Cai, Wei Gao, Xiuzhen Tang, Yini Chen, Jie Chen, Li Chen, Qiwei Tian, Shiping Yang, Yuanyi Zheng, Bing Hu
Background: The intrinsic properties of Prussian blue (PB) nanoparticles make them an attractive tool in nanomedicine, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and photothermal therapy (PTT) properties. However, there still remains the challenge of their poor dispersible stability in the physiological environment. In this study, we developed an efficient hydrothermal method to address the poor dispersible stability of PB nanoparticles in the physiological environment...
2019: International Journal of Nanomedicine
Elham Behzadi, Rozhin Sarsharzadeh, Mina Nouri, Farnoosh Attar, Keivan Akhtari, Koorosh Shahpasand, Mojtaba Falahati
Background: Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed. Methods: Herein, the interaction of magnesium oxide nanoparticles (MgO NPs) with HSA was studied by means of fluorescence spectroscopy, circular dichroism (CD) spectroscopy, and docking studies...
2019: International Journal of Nanomedicine
Tabassom Sedaghat Anbouhi, Elnaz Mokhtari Esfidvajani, Fahimeh Nemati, Setareh Haghighat, Soyar Sari, Farnoosh Attar, Arezoo Pakaghideh, Mohammad Javad Sohrabi, Seyyedeh Elaheh Mousavi, Mojtaba Falahati
Background: Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies should be done to explore their biological responses. Aim: In this study, protein binding, anticancer and antibacterial activates of zero valent iron (ZVFe) were explored. Materials and methods: ZVFe nanoparticles were synthesized and fully characterized by X-ray diffraction, field-emission scanning electron microscope, and dynamic light scattering analyses...
2019: International Journal of Nanomedicine
Ying Zhuge, Huan-Er Ni, Yu-Jie Wang, Mu-Ye He, Jun-Shan Wang, Feng Gao, Fang Wang
Aims: To determine whether use of radiofrequency catheter ablation (RFCA) combined with intravenously administered liposomal doxorubicin (L-DOX) facilitates a reduction in the recovery of post-ablation electrical conduction. Methods: Circumferential ablation was performed on the epicardial surface of the left atrial appendage (LAA) in New Zealand White rabbits, and L-DOX was then administered intravenously. Fluorescence spectrophotometry was used to assess reagent bio-distribution, while Western blots and immunohistochemistry were used to assess the localization of the apoptotic markers Bcl-2, Bax, and cleaved CASP3 in the LAA...
2019: International Journal of Nanomedicine
Zhihuang Zheng, Guoying Deng, Chenyang Qi, Yuyin Xu, Xijian Liu, Zhonghua Zhao, Zhigang Zhang, Yuening Chu, Huijuan Wu, Jun Liu
Objectives: Acute kidney injury (AKI) is a growing global health concern, and is associated with high rates of mortality and morbidity in intensive care units. Se is a trace element with antioxidant properties. This study aimed to determine whether porous Se@SiO2 nanospheres could relieve oxidative stress and inflammation in ischemia/reperfusion (I/R)-induced AKI. Methods: Male 6- to 8-week-old C57bl/6 mice were divided into four groups: sham + saline, sham + Se@SiO2 , I/R + saline, and I/R + Se@SiO2 ...
2019: International Journal of Nanomedicine
Qinglin Shen, Haitao Yang, Caixia Peng, Han Zhu, Jia Mei, Shan Huang, Bin Chen, Jue Liu, Wenbo Wu, Shaokui Cao
Background: Efficient and precise circulating tumor cells' (CTCs) capture and release with minimal effect on cell viability for CTCs' analysis are general requirements of CTCs' detection device in clinical application. However, these two essential factors are difficult to be achieved simultaneously. Methods: In order to reach the aforementioned goal, we integrated multiple strategies and technologies of staggered herringbone structure, nanowires' substrate, peptides, enzymatic release, specific cell staining, and gene sequencing into microfluidic device and the sandwich structure peptide-silicon nanowires' substrate was termed as Pe-SiNWS...
2019: International Journal of Nanomedicine
Xiao-Chuan Duan, Xin Yao, Shuang Zhang, Mei-Qi Xu, Yan-Li Hao, Zhan-Tao Li, Xiu-Chai Zheng, Man Liu, Zhuo-Yue Li, Hui Li, Jing-Ru Wang, Zhen-Han Feng, Xuan Zhang
Background: 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX) is a paclitaxel (PTX) bioreductive prodrug synthesized by our lab. We hypothesize that NPPA-PTX can self-assemble to form nanoparticles (NPs). Materials and methods: In the present research, the theoretical partition coefficient (XlogP) and Hansen solubility parameters of NPPA-PTX were calculated. NPPA-PTX nanoparticles prepared by NPPA-PTX and DSPE-PEG (NPPA-PTX:DSPE-PEG =1:0.1, w/w) (NPPA-PTX@PEG NPs) were prepared and characterized...
2019: International Journal of Nanomedicine
Chun-Chiao Chuang, Chih-Chi Cheng, Pei-Ying Chen, Chieh Lo, Yi-Ning Chen, Min-Hsiung Shih, Chien-Wen Chang
Purpose: A biocompatible nanocomplex system co-encapsulated with gold nanorods (AuNRs) and doxorubicin (DOX) was investigated for its potentials on the combined photothermal- and chemotherapy. Materials and methods: Hydrophobic AuNRs were synthesized by the hexadecyltrimethyl-ammonium bromide (CTAB)-mediated seed growth method, and then, they received two-step surface modifications of polyethylene glycol (PEG) and dodecane. The AuNR/DOX/poly(lactic- co -glycolic acid) (PLGA) nanocomplexes were prepared by emulsifying DOX, AuNR, and PLGA into aqueous polyvinyl alcohol solution by sonication...
2019: International Journal of Nanomedicine
Stephan Lugert, Harald Unterweger, Marina Mühlberger, Christina Janko, Sebastian Draack, Frank Ludwig, Dietmar Eberbeck, Christoph Alexiou, Ralf P Friedrich
Background: Magnetic drug targeting (MDT) is an effective alternative for common drug applications, which reduces the systemic drug load and maximizes the effect of, eg, chemotherapeutics at the site of interest. After the conjugation of a magnetic carrier to a chemotherapeutic agent, the intra-arterial injection into a tumor-afferent artery in the presence of an external magnetic field ensures the accumulation of the drug within the tumor tissue. Materials and methods: In this study, we used superparamagnetic iron oxide nanoparticles (SPIONs) coated with lauric acid and human serum albumin as carriers for paclitaxel (SPIONLA-HSA-Ptx )...
2019: International Journal of Nanomedicine
Lingxiao Chen, Wei He, Huichuan Jiang, Longxiang Wu, Wei Xiong, Bolun Li, Zhihua Zhou, Yuna Qian
Purpose: PB is one of the most severe complications of late stage prostate cancer and negatively impacts patient quality of life. A major challenge for the treatment of cancer bone metastasis is the management of efficient drug delivery to metastatic bone lesion. We aimed to explore the use of aptamers as promising tools to develop a targeted drug delivery system for PBs. Materials and methods: In vivo SELEX was applied to identify bone targeting aptamer in a mouse model with PBs...
2019: International Journal of Nanomedicine
Yating Sun, Yarong Zhao, Shanshan Teng, Fei Hao, Huan Zhang, Fanchao Meng, Xiuting Zhao, Xiaolong Zheng, Ye Bi, Yicheng Yao, Robert J Lee, Lesheng Teng
Background: We previously developed cabazitaxel (CTX)-loaded human serum albumin nanoparticles (NPs-CTX) via a self-assembly method, and these NPs showed efficacy in prostate cancer therapy. Many studies have shown that the levels of folic acid (FA) receptor on the surface of various tumor cells are high. Therefore, FA-modified NPs-CTX may have enhanced antitumor effects compared with unmodified NPs-CTX. Methods: NPs-CTX were first prepared via self-assembly, and FA was conjugated on the surface of NPs-CTX through the -NH2 groups of the NPs to produce FA-NPs-CTX...
2019: International Journal of Nanomedicine
Zaijin Teng, Miao Yu, Yang Ding, Huaqing Zhang, Yan Shen, Menglao Jiang, Peixin Liu, Yaw Opoku-Damoah, Thomas J Webster, Jianping Zhou
Purpose: Nimodipine (NMP) is a clinical dihydropyridine calcium antagonist. However, the clinical application of NMP is limited by poor water solubility and low oral bioavailability. To overcome these drawbacks, this study designed optimal NMP-incorporated nanostructured lipid carriers (NLCs). Methods: High-pressure homogenization was successfully applied to prepare NMP-NLC, and the nanoparticle morphology was observed by a transmission electron microscope. The existence form of NMP in NMP-NLC was investigated by powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy, respectively...
2019: International Journal of Nanomedicine
Chen Shen, Xiaoxiong Wang, Zhixing Zheng, Chuang Gao, Xin Chen, Shiguang Zhao, Zhifei Dai
Background: Glioma represents the most common malignant brain tumor. Outcomes of surgical resection are often unsatisfactory due to low sensitivity or resolution of imaging methods. Moreover, the use of traditional chemotherapeutics, such as doxorubicin (DOX), is limited due to their low blood-brain barrier (BBB) permeability. Recently, the development of nanotechnology could overcome these obstacles. Materials and methods: Hydrophobic superparamagnetic iron oxide nanoparticles (SPIO NPs) were prepared with the use of thermal decomposition method...
2019: International Journal of Nanomedicine
Huzaifa Umar, Doga Kavaz, Nahit Rizaner
Background: Biocompatibility and stability of zinc oxide nanoparticles (ZnO NPs) synthesized using plants is an interesting research area of study in nanotechnology, due to its wide applications in biomedical, industrial, cell imaging, and biosensor fields. The present study reports the novel green synthesis of stable ZnO NPs using various concentrations of zinc nitrate (0.01M, 0.05M, 0.1M) and Albizia lebbeck stem bark extracts as an efficient chelating agent. Antimicrobial, antioxidant, cytotoxic, and antiproliferative activities of the synthesized NPs on human breast cancer cell lines were evaluated using different assays...
2019: International Journal of Nanomedicine
Chan Wu, Yang Zhang, Daoqiu Yang, Jinfeng Zhang, Juanjuan Ma, Dan Cheng, Jianming Chen, Li Deng
Background: Many novel drug delivery systems have been extensively studied to exploit the full therapeutic potential of SN38, which is one of the most potent antitumor analogs of camptothecins (CPTs), whose clinical application is seriously hindered by poor water solubility, low plasmatic stability, and severe toxicity, but results are always unsatisfactory. Methods: In this study, combining the advantages of prodrug and nanotechnology, a lipophilic prodrug of SN38, SN38-PA, was developed by conjugating palmitic acid to SN38 via ester bond at C10 position, and then the lipophilic prodrug was encapsulated into a long-circulating liposomal carrier by film dispersion method...
2019: International Journal of Nanomedicine
Yang Chen, Wei Liu, Yue Shang, Peipei Cao, Jianlin Cui, Zongjin Li, Xuebo Yin, Yuhao Li
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and severely threatens human health. Since the prognosis of advanced HCC remains poor, there is an urgent need to develop new therapeutic approaches. Porphyrin metal-organic frameworks are a class of porous organic-inorganic hybrid functional materials with good biocompatibility. Methods: Gadolinium-porphyrin metal-organic frameworks were used as a skeleton for folic acid (FA) conjugation to synthesize a novel type of nanoparticle, denoted as folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks (FA-NPMOFs)...
2019: International Journal of Nanomedicine
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