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International Journal of Nanomedicine

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https://www.readbyqxmd.com/read/28424550/doxorubicin-loaded-poly-lactic-co-glycolic-acid-nanoparticles-coated-with-chitosan-alginate-by-layer-by-layer-technology-for-antitumor-applications
#1
Fujuan Chai, Linlin Sun, Xinyi He, Jieli Li, Yuanfen Liu, Fei Xiong, Liang Ge, Thomas J Webster, Chunli Zheng
Natural polyelectrolyte multilayers of chitosan (CHI) and alginate (ALG) were alternately deposited on doxorubicin (DOX)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) with layer by layer self-assembly to control drug release for antitumor activity. Numerous factors which influenced the multilayer growth on nano-colloidal particles were studied: polyelectrolyte concentration, NaCl concentration and temperature. Then the growth regime of the CHI/ALG multilayers was elucidated. The coated NPs were characterized by transmission electron microscopy, atomic force microscopy, X-ray diffraction and a zeta potential analyzer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408827/photothermal-modulated-drug-delivery-and-magnetic-relaxation-based-on-collagen-poly-%C3%AE-glutamic-acid-hydrogel
#2
Sun-Hee Cho, Ahreum Kim, Woojung Shin, Min Beom Heo, Hyun Jong Noh, Kwan Soo Hong, Jee-Hyun Cho, Yong Taik Lim
Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging and drug delivery because encapsulated diagnostic or therapeutic components in the hydrogel can be used to image or change the microenvironment of the injection site by controlling various stimuli such as enzymes, temperature, pH, and photonic energy. In this study, we developed a novel injectable and photoresponsive composite hydrogel composed of anticancer drugs, imaging contrast agents, bio-derived collagen, and multifaceted anionic polypeptide, poly (γ-glutamic acid) (γ-PGA)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408826/durable-antibacterial-and-uv-protective-ag-tio2-fabrics-for-sustainable-biomedical-application
#3
Shuhui Li, Tianxue Zhu, Jianying Huang, Qingqing Guo, Guoqiang Chen, Yuekun Lai
A facile method was developed to endow cotton fabric with remarkable antibacterial and ultraviolet (UV)-protective properties. The flower-like TiO2 micro-nanoparticles were first deposited onto cotton fabric surface via hydrothermal deposition method. Then, the Ag NPs with a high deposition density were evenly formed onto TiO2@cotton surface by sodium hydroxide solution pretreatment and followed by in situ reduction of ANO3. This work focused on the influence of different hydrothermal reaction durations and the concentration of AgNO3 on antibacterial activity against relevant microorganisms in medicine as well as on the UV-blocking property...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408825/a-tetraethylene-glycol-coat-gives-gold-nanoparticles-long-in-vivo-half-lives-with-minimal-increase-in-size
#4
Julian Ds Willett, Marlon G Lawrence, Jennifer C Wilder, Oliver Smithies
In this study, we describe the experiments determining whether coating gold nanoparticles with tetraethylene glycol (TEG) provides pharmacologically relevant advantages, such as increased serum half-life and resistance to protein adsorption. Monodisperse TEG-coated, NaBH4-reduced gold nanoparticles with a hydrodynamic size comparable to albumin were synthesized by reducing gold chloride with NaBH4 under alkaline conditions in the presence of TEG-SH. The particles were characterized by gel electrophoresis, column chromatography, and transmission electron microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408824/cuprous-oxide-nanoparticles-inhibit-prostate-cancer-by-attenuating-the-stemness-of-cancer-cells-via-inhibition-of-the-wnt-signaling-pathway
#5
Ye Wang, Qi-Wei Yang, Qing Yang, Tie Zhou, Min-Feng Shi, Chen-Xia Sun, Xiu-Xia Gao, Yan-Qiong Cheng, Xin-Gang Cui, Ying-Hao Sun
Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, whether CONPs have the potential to treat castration-resistant prostate cancer is still unknown. Here, using the castration-resistant PC-3 human prostate cancer cell line as a model, we report that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408823/gold-nanoparticles-enhance-trail-sensitivity-through-drp1-mediated-apoptotic-and-autophagic-mitochondrial-fission-in-nsclc-cells
#6
Sunkui Ke, Tong Zhou, Peiyan Yang, Yange Wang, Peng Zhang, Keman Chen, Lei Ren, Shefang Ye
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic receptors have been identified as highly promising antitumor agents preferentially eliminating cancer cells with minimal damage, the emergence of TRAIL resistance in most cancers may contribute to therapeutic failure. Thus, there is an urgent need for new approaches to overcome TRAIL resistance. Gold nanoparticles (AuNPs) are one of the most promising nanomaterials that show immense antitumor potential via targeting various cellular and molecular processes; however, the effects of AuNPs on TRAIL sensitivity in cancer cells remain unclear...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408822/negatively-charged-silver-nanoparticles-with-potent-antibacterial-activity-and-reduced-toxicity-for-pharmaceutical-preparations
#7
Lucia Salvioni, Elisabetta Galbiati, Veronica Collico, Giulia Alessio, Svetlana Avvakumova, Fabio Corsi, Paolo Tortora, Davide Prosperi, Miriam Colombo
BACKGROUND: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases. METHODS: Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408821/antitumor-activity-of-a-folate-receptor-targeted-immunoglobulin-g-doxorubicin-conjugate
#8
Tan Yang, Ling Xu, Bin Li, Weijie Li, Xiang Ma, Lingling Fan, Robert J Lee, Chuanrui Xu, Guangya Xiang
Development of antibody-drug conjugates (ADCs) is a promising therapeutic strategy for cancer therapy. In this study, folate was conjugated via a polyethyleneglycol (PEG) linker to immunoglobulin G (IgG), which was linked to doxorubicin (DOX), to form a novel ADC folate-PEG-IgG-DOX (FA-PEG-IgG-DOX). The FA-PEG-IgG-DOX showed high targeting efficiency in HeLa and KB cells and significantly improved the uptake and retention of DOX compared with IgG-DOX about 10-fold. Subsequently, FA-PEG-IgG-DOX was shown to have at least 8 times higher antitumor activity than IgG-DOX both in HeLa and KB cells and also induced more apoptosis in those cells than IgG-DOX...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408820/curcumin-loaded-redox-response-of-self-assembled-micelles-for-enhanced-antitumor-and-anti-inflammation-efficacy
#9
Shuang Zhao, Litao Ma, Chengwen Cao, Qianqian Yu, Lanmei Chen, Jie Liu
At present, it has become evident that inflammation plays a critical role in tumor growth; meanwhile, chemotherapeutic agents using nanocarriers have been suggested as a promising strategy in cancer treatment. In this study, novel redox-responsive micelles were prepared from monomethoxy-poly(ethylene glycol)-chitosan-S-S-hexadecyl (C16-SS-CS-mPEG). These micelles were able to carry and deliver drugs into tumor cells. To serve as a control, monomethoxy-poly(ethylene glycol)-chitosan-C-C-hexadecyl (C16-CC-CS-mPEG) was developed in a similar fashion to that used to yield C16-CC-CS-mPEG without a redox-responsive disulfide bond...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408819/simvastatin-nanoparticles-attenuated-intestinal-ischemia-reperfusion-injury-by-downregulating-bmp4-cox-2-pathway-in-rats
#10
Fei Tong, Bo Dong, Rongkui Chai, Ke Tong, Yini Wang, Shipiao Chen, Xinmei Zhou, Daojun Liu
The purpose of the research was to explore the therapeutic action of simvastatin-loaded poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) (PEG-b-PBLG50) on intestinal ischemia/reperfusion injury (II/RI) through downregulating bone morphogenetic protein 4 (BMP4)/cyclooxygenase-2 (COX-2) pathway as compared to free simvastatin (Sim). Sprague Dawley rats were preconditioned with 20 mg/kg Sim or simvastatin/PEG-b-PBLG50 (Sim/P) compounds, and then subjected to 45 min of ischemia and 1 h of reperfusion. The blood and small intestines were collected, serum levels of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α, and nitric oxide (NO) were checked, and the dry/wet intestine ratios, superoxide dismutase activity, myeloperoxidase content, reactive oxygen species, endothelial nitric oxide synthase, protein 47 kDa phagocyte oxidase (p47phox), BMP4, COX-2, and p38 mitogen-activated protein kinase (p38MAPK) expressions were measured in intestinal tissues...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408818/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingiber-cassumunar-roxb-by-therapeutic-ultrasound-in-a-rat-model
#11
Jirakrit Leelarungrayub, Jiradej Manorsoi, Aranya Manorsoi
OBJECTIVE: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408817/shape-dependent-antibacterial-effects-of-non-cytotoxic-gold-nanoparticles
#12
Jelle Penders, Michelle Stolzoff, Daniel J Hickey, Martin Andersson, Thomas J Webster
Gold nanoparticles (AuNPs) of various shapes (including spheres, stars and flowers), with similar dimensions, were synthesized and evaluated for their antibacterial effects toward Staphylococcus aureus, a bacterium responsible for numerous life-threatening infections worldwide. Optical growth curve measurements and Gompertz modeling showed significant AuNP shape- and concentration-dependent decreases in bacterial growth with increases in bacterial growth lag time. To evaluate prospective use in in vivo systems, the cytotoxicity of the same AuNPs was evaluated toward human dermal fibroblasts in vitro by 3-(4,5 dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) viability assays and confocal microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408816/zonisamide-loaded-triblock-copolymer-nanomicelles-as-a-novel-drug-delivery-system-for-the-treatment-of-acute-spinal-cord-injury
#13
JingLun Li, JiaoJiao Deng, JinXian Yuan, Jie Fu, XiaoLing Li, AiPing Tong, YueLong Wang, YangMei Chen, Gang Guo
Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(l-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28405165/enhancement-of-physicochemical-properties-of-nanocolloidal-carrier-loaded-with-cyclosporine-for-topical-treatment-of-psoriasis-in-vitro-diffusion-and-in-vivo-hydrating-action
#14
Siti Hajar Musa, Mahiran Basri, Hamid Reza Fard Masoumi, Norashikin Shamsudin, Norazlinaliza Salim
Psoriasis is a chronic autoimmune disease that cannot be cured. It can however be controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment is the first-line treatment and favored by most physicians, as this form of therapy has more patient compliance. Introducing a nanoemulsion for transporting cyclosporine as an anti-inflammatory drug to an itchy site of skin disease would enhance the effectiveness of topical treatment for psoriasis. The addition of nutmeg and virgin coconut-oil mixture, with their unique properties, could improve cyclosporine loading and solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28405164/a-dual-mediated-liposomal-drug-delivery-system-targeting-the-brain-rational-construction-integrity-evaluation-across-the-blood-brain-barrier-and-the-transporting-mechanism-to-glioma-cells
#15
Chang Liu, Xiao-Na Liu, Gui-Ling Wang, Yu Hei, Shuai Meng, Ling-Fei Yang, Lan Yuan, Ying Xie
As the global population ages, cancer rates increase worldwide, and degenerative diseases of the central nervous system (CNS), brain tumors, and inflammation threaten human health more frequently. We designed a dual-mediated (receptor-mediated and adsorption-mediated) liposome, named transferrin-cell penetrating peptide-sterically stabilized liposome (TF-CPP-SSL), to improve therapy for gliomas through combining molecular recognition of transferrin receptors (TF-Rs) on the blood-brain barrier (BBB) and glioma cells with the internalization and lysosomal escaping ability of CPP...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28405163/enhancing-sirna-based-cancer-therapy-using-a-new-ph-responsive-activatable-cell-penetrating-peptide-modified-liposomal-system
#16
Bai Xiang, Xue-Li Jia, Jin-Long Qi, Li-Ping Yang, Wei-Hong Sun, Xiao Yan, Shao-Kun Yang, De-Ying Cao, Qing Du, Xian-Rong Qi
As a potent therapeutic agent, small interfering RNA (siRNA) has been exploited to silence critical genes involved in tumor initiation and progression. However, development of a desirable delivery system is required to overcome the unfavorable properties of siRNA such as its high degradability, molecular size, and negative charge to help increase its accumulation in tumor tissues and promote efficient cellular uptake and endosomal/lysosomal escape of the nucleic acids. In this study, we developed a new activatable cell-penetrating peptide (ACPP) that is responsive to an acidic tumor microenvironment, which was then used to modify the surfaces of siRNA-loaded liposomes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392694/a-review-on-current-nanomaterials-and-their-drug-conjugate-for-targeted-breast-cancer-treatment
#17
REVIEW
Joanna Jinling Lee, Latifah Saiful Yazan, Che Azurahanim Che Abdullah
Breast cancer is the most common malignancy worldwide, especially among women, with substantial after-treatment effects. The survival rates of breast cancer have decreased over the years even with the existence of various therapeutic strategies, specifically, chemotherapy. Clinical drugs administered for breast cancer appear to be non-targeting to specific cancer sites leading to severe side effects and potentially harming healthy cells instead of just killing cancer cells. This leads to the need for designing a targeted drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392693/sustained-release-of-anticancer-agent-phytic-acid-from-its-chitosan-coated-magnetic-nanoparticles-for-drug-delivery-system
#18
Farahnaz Barahuie, Dena Dorniani, Bullo Saifullah, Sivapragasam Gothai, Mohd Zobir Hussein, Ashok Kumar Pandurangan, Palanisamy Arulselvan, Mohd Esa Norhaizan
Chitosan (CS) iron oxide magnetic nanoparticles (MNPs) were coated with phytic acid (PTA) to form phytic acid-chitosan-iron oxide nanocomposite (PTA-CS-MNP). The obtained nanocomposite and nanocarrier were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometry, transmission electron microscopy, and thermogravimetric and differential thermogravimetric analyses. Fourier transform infrared spectra and thermal analysis of MNPs and PTA-CS-MNP nanocomposite confirmed the binding of CS on the surface of MNPs and the loading of PTA in the PTA-CS-MNP nanocomposite...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392692/antifungal-optical-and-mechanical-properties-of-polymethylmethacrylate-material-incorporated-with-silanized-zinc-oxide-nanoparticles
#19
Krid Kamonkhantikul, Mansuang Arksornnukit, Hidekazu Takahashi
BACKGROUND: Fungal infected denture, which is typically composed of polymethylmethacrylate (PMMA), is a common problem for a denture wearer, especially an elderly patient with limited manual dexterity. Therefore, increasing the antifungal effect of denture by incorporating surface modification nanoparticles into the PMMA, while retaining its mechanical properties, is of interest. AIM OF THE STUDY: This study aimed to evaluate antifungal, optical, and mechanical properties of heat-cured PMMA incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) with or without methacryloxypropyltrimethoxysilane modification...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28392691/ketoprofen-loaded-eudragit-electrospun-nanofibers-for-the-treatment-of-oral-mucositis
#20
Rana Ihab Reda, Ming Ming Wen, Amal Hassan El-Kamel
PURPOSE: The purpose of this study was to formulate ketoprofen (KET)-loaded Eudragit L and Eudragit S nanofibers (NFs) by the electrospinning technique for buccal administration to treat oral mucositis as a safe alternative to orally administered KET, which causes gastrointestinal tract (GIT) side effects. MATERIALS AND METHODS: NFs were prepared by electrospinning using Eudragit L and Eudragit S. Several variables were evaluated to optimize NF formulation, such as polymer types and concentrations, applied voltage, flow rate and drug concentrations...
2017: International Journal of Nanomedicine
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