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International Journal of Nanomedicine

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https://www.readbyqxmd.com/read/28533682/polyethylene-glycol-poly-%C3%AE%C2%B5-benzyloxycarbonyl-l-lysine-conjugated-vegf-sirna-for-antiangiogenic-gene-therapy-in-hepatocellular-carcinoma
#1
Gangmin Wang, XiaoLong Gao, GuoJun Gu, ZhiHong Shao, MingHua Li, PeiJun Wang, JianRong Yang, XiaoJun Cai, YongYong Li
A polyethylene glycol-poly(ε-benzyloxycarbonyl-l-lysine) (PEG-SS-PLL) block copolymer based on a disulfide-linked, novel biodegradable catiomer bearing a PEG-sheddable shell was developed to avoid "PEG dilemma" in nanoparticle intracellular tracking of PEG-PLL where PEG was nondegradable. However, PEG-SS-PLL catiomers have not been used to deliver small interfering VEGF RNA (siVEGF) in antiangiogenesis gene therapy. In this study, we aimed to investigate whether this novel biodegradable catiomer can deliver siVEGF into cancer cells and at the same time have an antitumor effect in a xenograft mouse model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28533681/synergistic-bactericidal-activity-of-chlorhexidine-loaded-silver-decorated-mesoporous-silica-nanoparticles
#2
Meng-Meng Lu, Qiu-Jing Wang, Zhi-Min Chang, Zheng Wang, Xiao Zheng, Dan Shao, Wen-Fei Dong, Yan-Min Zhou
Combination of chlorhexidine (CHX) and silver ions could engender synergistic bactericidal effect and improve the bactericidal efficacy. It is highly desired to develop an efficient carrier for the antiseptics codelivery targeting infection foci with acidic microenvironment. In this work, monodisperse mesoporous silica nanoparticle (MSN) nanospheres were successfully developed as an ideal carrier for CHX and nanosilver codelivery through a facile and environmentally friendly method. The CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) exhibited a pH-responsive release manner of CHX and silver ions simultaneously, leading to synergistically antibacterial effect against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28507436/design-of-polyaspartic-acid-peptide-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-nanoparticles-as-a-carrier-of-hydrophobic-drugs-targeting-cancer-metastasized-to-bone
#3
Jinsong Liu, Youyun Zeng, Shuai Shi, Lihua Xu, Hualin Zhang, Janak L Pathak, Yihuai Pan
Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp)8, has a strong affinity to bone surface. The aim of this study was to synthesize (Asp)8-PEG-PCL nanoparticles as a bone-specific carrier of hydrophobic drugs to treat cancer metastasized to bone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28507435/mesoporous-silica-nanoparticles-trigger-mitophagy-in-endothelial-cells-and-perturb-neuronal-network-activity-in-a-size-and-time-dependent-manner
#4
Antonina Orlando, Emanuela Cazzaniga, Maria Tringali, Francesca Gullo, Andrea Becchetti, Stefania Minniti, Francesca Taraballi, Ennio Tasciotti, Francesca Re
PURPOSE: Mesoporous silica nanoparticles (MSNPs) are excellent candidates for biomedical applications and drug delivery to different human body areas, the brain included. Although toxicity at cellular level has been investigated, we are still far from using MSNPs in the clinic, because the mechanisms involved in the cellular responses activated by MSNPs have not yet been elucidated. MATERIALS AND METHODS: This study used an in vitro multiparametric approach to clarify relationships among size, dose, and time of exposure of MSNPs (0...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28507434/enhanced-oral-bioavailability-of-valsartan-using-a-polymer-based-supersaturable-self-microemulsifying-drug-delivery-system
#5
Dong Woo Yeom, Bo Ram Chae, Ho Yong Son, Jin Han Kim, Jun Soo Chae, Seh Hyon Song, Dongho Oh, Young Wook Choi
A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul(®) MCM, 45% Tween(®) 20, and 45% Transcutol(®) P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28503066/essential-oil-mediated-glycerosomes-increase-transdermal-paeoniflorin-delivery-optimization-characterization-and-evaluation-in-vitro-and-in-vivo
#6
Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng
In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496326/gold-nanoparticles-attenuate-metastasis-by-tumor-vasculature-normalization-and-epithelial-mesenchymal-transition-inhibition
#7
Wei Li, Xin Li, Shuhao Liu, Wende Yang, Fan Pan, Xiao-Yan Yang, Bin Du, Li Qin, Yunlong Pan
Angiogenesis is a process by which vessels are formed through preexisting ones, and this plays a key role in the progression of solid tumors. However, tumor vessels are influenced by excessive pro-angiogenic factors, resulting in deformed structures that facilitate the intravasation of tumor cells into the circulation and subsequent metastasis. Moreover, abnormal tumor vessels have low blood perfusion and thereby decreased oxygen infusion into tumors. This results in a hostile microenvironment that promotes epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose their polarity and gain increased motility, which is associated with metastasis and invasion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496325/multifunctional-and-biomimetic-fish-collagen-bioactive-glass-nanofibers-fabrication-antibacterial-activity-and-inducing-skin-regeneration-in-vitro-and-in-vivo
#8
Tian Zhou, Baiyan Sui, Xiumei Mo, Jiao Sun
The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496324/preparation-of-zein-nanoparticles-by-using-solution-enhanced-dispersion-with-supercritical-co2-and-elucidation-with-computational-fluid-dynamics
#9
Sining Li, Yaping Zhao
Nanoparticles have attracted more and more attention in the medicinal field. Zein is a biomacromolecule and can be used as a carrier for delivering active ingredients to prepare controlled release drugs. In this article, we presented the preparation of zein nanoparticles by solution-enhanced dispersion by supercritical CO2 (SEDS) approach. Scanning electron microscopy and transmission electron microscopy were applied to characterize the size and morphology of the obtained particles. The nozzle structure and the CO2 flow rate greatly affected the morphology and the size of the particles...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496323/a-novel-nanoemulsion-based-method-to-produce-ultrasmall-water-dispersible-nanoparticles-from-chitosan-surface-modified-with-cell-penetrating-peptide-for-oral-delivery-of-proteins-and-peptides
#10
Ghullam Reza Barbari, Farid Abedin Dorkoosh, Mohsen Amini, Mohammad Sharifzadeh, Fateme Atyabi, Saeed Balalaie, Niyousha Rafiee Tehrani, Morteza Rafiee Tehrani
A simple and reproducible water-in-oil (W/O) nanoemulsion technique for making ultrasmall (<15 nm), monodispersed and water-dispersible nanoparticles (NPs) from chitosan (CS) is reported. The nano-sized (50 nm) water pools of the W/O nanoemulsion serve as "nano-containers and nano-reactors". The entrapped polymer chains of CS inside these "nano-reactors" are covalently cross-linked with the chains of polyethylene glycol (PEG), leading to rigidification and formation of NPs. These NPs possess excessive swelling properties in aqueous medium and preserve integrity in all pH ranges due to chemical cross-linking with PEG...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496322/photoresponsive-nanocapsulation-of-cobra-neurotoxin-and-enhancement-of-its-central-analgesic-effects-under-red-light
#11
Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye
Cobra neurotoxin (CNT), a peptide isolated from snake venom of Naja naja atra, shows central analgesic effects in our previous research. In order to help CNT pass through blood-brain barrier (BBB) and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496321/development-of-99m-tc-radiolabeled-nanosilica-for-targeted-detection-of-her2-positive-breast-cancer
#12
Paolo Rainone, Benedetta Riva, Sara Belloli, Francesco Sudati, Marilena Ripamonti, Paolo Verderio, Miriam Colombo, Barbara Colzani, Maria Carla Gilardi, Rosa Maria Moresco, Davide Prosperi
The human epidermal growth factor receptor 2 (HER2) is normally associated with a highly aggressive and infiltrating phenotype in breast cancer lesions with propensity to spread into metastases. In clinic, the detection of HER2 in primary tumors and in their metastases is currently based on invasive methods. Recently, nuclear molecular imaging techniques, including positron emission tomography and single photon emission computed tomography (SPECT), allowed the detection of HER2 lesions in vivo. We have developed a (99m)Tc-radiolabeled nanosilica system, functionalized with a trastuzumab half-chain, able to act as drug carrier and SPECT radiotracer for the identification of HER2-positive breast cancer cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496320/induction-of-mitophagy-mediated-antitumor-activity-with-folate-appended-methyl-%C3%AE-cyclodextrin
#13
Kazuhisa Kameyama, Keiichi Motoyama, Nao Tanaka, Yuki Yamashita, Taishi Higashi, Hidetoshi Arima
Mitophagy is the specific autophagic elimination system of mitochondria, which regulates cellular survival via the removal of damaged mitochondria. Recently, we revealed that folate-appended methyl-β-cyclodextrin (FA-M-β-CyD) provides selective antitumor activity in folate receptor-α (FR-α)-expressing cells by the induction of autophagy. In this study, to gain insight into the detailed mechanism of this antitumor activity, we focused on the induction of mitophagy by the treatment of FR-α-expressing tumor cells with FA-M-β-CyD...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28496319/in-vivo-toxicologic-study-of-larger-silica-nanoparticles-in-mice
#14
Wai-Tao Chan, Cheng-Che Liu, Jen-Shiu Chiang Chiau, Shang-Ting Tsai, Chih-Kai Liang, Mei-Lien Cheng, Hung-Chang Lee, Chun-Yun Yeung, Shao-Yi Hou
Silica nanoparticles (SiNPs) are being studied and used for medical purposes. As nanotechnology grows rapidly, its biosafety and toxicity have frequently raised concerns. However, diverse results have been reported about the safety of SiNPs; several studies reported that smaller particles might exhibit toxic effects to some cell lines, and larger particles of 100 nm were reported to be genotoxic to the cocultured cells. Here, we investigated the in vivo toxicity of SiNPs of 150 nm in various dosages via intravenous administration in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490879/methodological-assessment-of-the-reduction-of-the-content-of-impurities-in-nimodipine-emulsion-via-the-use-of-21-amino-acid-protection
#15
Yiqiao Xie, Zhiquan Zhuang, Shu Zhang, Zihua Xia, De Chen, Kaiyan Fan, Jialin Ren, CuiCui Lin, Yanzhong Chen, Fan Yang
PURPOSE: The present study examined the factors affecting the content of impurities of nimodipine (NMP) emulsion and the associated methods of compound protection. METHODS: Destructive testing of NMP emulsion and its active pharmaceutical ingredient (API) were conducted, and ultracentrifugation was used to study the content of impurities in two phases. The impurity of NMP was measured under different potential of hydrogen (pH) conditions, antioxidants and pH-adjusting agents...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490878/a-novel-injectable-calcium-phosphate-based-nanocomposite-for-the-augmentation-of-cannulated-pedicle-screw-fixation
#16
Haolin Sun, Chun Liu, Huiling Liu, Yanjie Bai, Zheng Zhang, Xuwen Li, Chunde Li, Huilin Yang, Lei Yang
Polymethyl methacrylate (PMMA)-augmented cannulated pedicle-screw fixation has been routinely performed for the surgical treatment of lumbar degenerative diseases. Despite its satisfactory clinical outcomes and prevalence, problems and complications associated with high-strength, stiff, and nondegradable PMMA have largely hindered the long-term efficacy and safety of pedicle-screw fixation in osteoporotic patients. To meet the unmet need for better bone cement for cannulated pedicle-screw fixation, a new injectable and biodegradable nanocomposite that was the first of its kind was designed and developed in the present study...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490877/low-density-lipoprotein-coupled-micelles-with-reduction-and-ph-dual-sensitivity-for-intelligent-co-delivery-of-paclitaxel-and-sirna-to-breast-tumor
#17
Wen-Jing Zhu, Shu-di Yang, Chen-Xi Qu, Qiao-Ling Zhu, Wei-Liang Chen, Fang Li, Zhi-Qiang Yuan, Yang Liu, Ben-Gang You, Xue-Nong Zhang
Multidrug resistance (MDR) is a major obstacle for the clinical therapy of malignant human cancers. The discovery of RNA interference provides efficient gene silencing within tumor cells for reversing MDR. In this study, a new "binary polymer" low-density lipoprotein-N-succinyl chitosan-cystamine-urocanic acid (LDL-NSC-SS-UA) with dual pH/redox sensitivity and targeting effect was synthesized for the co-delivery of breast cancer resistance protein small interfering RNA (siRNA) and paclitaxel (PTX). In vivo, the co-delivering micelles can accumulate in tumor tissue via the enhanced permeability and retention effect and the specific recognition and combination of LDL and LDL receptor, which is overexpressed on the surface of tumor cell membranes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490876/one-pot-synthesis-of-dextran-coated-iron-oxide-nanoclusters-for-real-time-regional-lymph-node-mapping
#18
Chaoping Fu, Haipeng Zhou, Yanan Wang, Dong Liu, Junmeng Li, Haijun Deng, Xiaolong Qi, Tao Chen, Li-Ming Zhang, Guoxin Li
The intraoperative precision cleaning of lymph nodes (LNs) is an essential component of treating neoplastic disease. To develop efficient probes for the targeted detection of LNs that could act as carriers for the specific diagnosis and treatment of metastatic LNs in the future, dextran-coated iron oxide nanoclusters (DIONs) were synthesized using a one-pot coprecipitation procedure. These modified DIONs have good water dispersibility, cytocompatibility, an optimum size, and a stable, dark brown color for LN imaging...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490875/mechanism-of-transdermal-permeation-promotion-of-lipophilic-drugs-by-ethosomes
#19
Li Yang, Lifang Wu, Dongze Wu, Deshun Shi, Tai Wang, Xiaoliang Zhu
Ethosomes can promote the penetration of lipophilic drugs into the skin, but the underlying mechanism is still unknown. The purpose of this study was to investigate the mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes. The formulation of ethosomes was optimized using the Box-Behnken experimental design, in which Rhodamine B and 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphocholine were used to simulate a model lipophilic drug and act as a fluorescent tracer of ethosomal phospholipids, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28490874/quantitative-and-multiplexed-detection-for-blood-typing-based-on-quantum-dot-magnetic-bead-assay
#20
Ting Xu, Qiang Zhang, Ya-Han Fan, Ru-Qing Li, Hua Lu, Shu-Ming Zhao, Tian-Lun Jiang
BACKGROUND: Accurate and reliable blood grouping is essential for safe blood transfusion. However, conventional methods are qualitative and use only single-antigen detection. We overcame these limitations by developing a simple, quantitative, and multiplexed detection method for blood grouping using quantum dots (QDs) and magnetic beads. METHODS: In the QD fluorescence assay (QFA), blood group A and B antigens were quantified using QD labeling and magnetic beads, and the blood groups were identified according to the R value (the value was calculated with the fluorescence intensity from dual QD labeling) of A and B antigens...
2017: International Journal of Nanomedicine
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