Read by QxMD icon Read

International Journal of Nanomedicine

Junyan Zhang, Mian Wang, Thomas J Webster
Background: Many cancer patients suffer from cancer-related life-threatening infections due to immune system damage. Therefore, researchers are continuously looking for new options to treat cancer-related infections. As nanotechnology has gained tremendous interest over the past several decades, silver nanoparticles have been investigated as an effective antimicrobial agent. Here, silver-coated gold nanorods were synthesized to share similar optical properties as gold nanopar-ticles for cancer diagnosis and treatment, with an added advantage of antibacterial properties...
2018: International Journal of Nanomedicine
Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni, Giulia Milanesi, Giovanna Bruni, Franca Ferrari
Aim: The aim of the present work was to develop biodegradable alginate (ALG)-containing fibrous membranes intended for tissue repair, acting as both drug delivery systems and cell growth guidance. Methods: Membranes were prepared by electrospinning. Since ALG can be electrospun only when blended with other spinnable polymers, dextran (DEX) and polyethylene oxide (PEO) were investigated as process adjuvants. ALG/DEX mixtures, characterized by different rheological and conductivity properties, were prepared in phosphate buffer or deionized water; surfactants were added to modulate polymer solution surface tension...
2018: International Journal of Nanomedicine
Chungmo Yang, Hae Hyun Hwang, Soohyun Jeong, Deokwon Seo, Yoon Jeong, Dong Yun Lee, Kangwon Lee
Purpose: Nitric oxide (NO) can be clinically applied at low concentrations to regulate angiogenesis. However, studies using small molecule NO donors ( N -diazeniumdiolate, S -nitrosothiol, etc) have yet to meet clinical requirements due to the short half-life and initial burst-release profile of NO donors. In this study, we report the feasibility of methoxy poly(ethylene glycol)-b-poly(lactic- co -glycolic acid) (mPEG-PLGA) nanoparticles (NPs) as NO-releasing polymers (NO-NPs) for inducing angiogenesis...
2018: International Journal of Nanomedicine
Yanqiu Zhang, Lianjun Peng, Jiahui Chu, Ming Zhang, Lizhu Sun, Bin Zhong, Qiyong Wu
Background: Co-delivery all-trans-retinoic acid (ATRA) and paclitaxel (PTX) is an effective strategy for cancer therapy. However, in many previous reported ATRA conjugated co-delivery systems, the ATRA was released slower than PTX, and the total drug release of ATRA far lower than that of PTX. Purpose: We designed and prepared a pH and redox dual responsive drug delivery system (DA-ss-NPs) co-delivery ATRA and PTX for cancer therapy. The surface charge of DA-ss-NPs could change from negative to positive under tumor slightly acidic microenvironment, and both drugs could be quickly released from DA-ss-NPs under intracellular high concentration of glutathione (GSH)...
2018: International Journal of Nanomedicine
(no author information available yet)
[This corrects the article on p. 3941 in vol. 12, PMID: 28579779.].
2018: International Journal of Nanomedicine
Lianhua Zhu, Luofu Wang, Yu Liu, Dan Xu, Kejing Fang, Yanli Guo
Purpose: Targeted nanobubbles can penetrate the tumor vasculature and achieve ultrasound molecular imaging (USMI) of tumor parenchymal cells. However, most targeted nanobubbles only achieve USMI of tumor parenchymal cells from one organ, and their distribution, loading ability, and binding ability in tumors are not clear. Therefore, targeted nanobubbles loaded with carbonic anhydrase IX (CAIX) aptamer were fabricated for USMI of various tumors, and the morphological basis of USMI with targeted nanobubbles was investigated...
2018: International Journal of Nanomedicine
Sharifah Nurfadhlin Afifah Syed Azhar, Siti Efliza Ashari, Norazlinaliza Salim
Introduction: Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation. In this study, KMO was formulated in an oil-in-water nanoemulsion as a carrier for better penetration into the skin. Methods: The nanoemulsion was prepared by using high and low energy emulsification technique. D-optimal mixture experimental design was generated as a tool for optimizing the composition of nanoemulsions suitable for topical delivery systems...
2018: International Journal of Nanomedicine
Lígia Nunes de Morais Ribeiro, Michelle Franz-Montan, Márcia Cristina Breitkreitz, Gustavo Henrique Rodrigues da Silva, Simone Ramos de Castro, Viviane Aparecida Guilherme, Daniele Ribeiro de Araújo, Eneida de Paula
Background: Local anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of the commercially available topical formulations is effective in eliminating the pain and phobia associated to the needle insertion and injection. Materials and methods: In this work we prepared a nanostructured lipid-biopolymer hydrogel for the sustained delivery of lidocaine-prilocaine (LDC-PLC) for transbuccal pre-anesthesia. The lipid was composed of optimized nanostructured lipid carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC)...
2018: International Journal of Nanomedicine
Jinli Wang, Min Jeong Seo, Michael B Deci, Brian R Weil, John M Canty, Juliane Nguyen
Background: After myocardial infarction (MI), inflammatory cells infiltrate the infarcted heart in response to secreted stimuli. Monocytes are recruited to the infarct via CCR2 chemokine receptors along a CCL2 concentration gradient. While infiltration of injured tissue with monocytes is an important component of the reparatory response, excessive or prolonged inflammation can adversely affect left ventricular remodeling and worsen clinical outcomes. Materials and methods: Here, we developed poly(ethylene glycol) (PEG)-distearoylphos-phatidylethanolamine (PEG-DSPE) micelles loaded with a small molecule CCR2 antagonist to inhibit monocyte recruitment to the infarcted myocardium...
2018: International Journal of Nanomedicine
Lubna Sherin, Shabieh Farwa, Ayesha Sohail, Zhiwu Li, O Anwar Bég
Background: Controlled inhibition of kinesin motor proteins is highly desired in the field of oncology. Among other interventions, there exists "targeted chemotherapeutic regime/options" of selective Eg5 competitive and allosteric inhibitors, inducing cancer cell apoptosis and tumor regression with improved safety profiles. Research question: Though promising, such studies are still under clinical trials, for the discovery of efficient and least harmful Eg5 inhibitors...
2018: International Journal of Nanomedicine
Xiaoming Zhao, Tianyang Qi, Chenfei Kong, Miao Hao, Yuqian Wang, Jing Li, Baocai Liu, Yiyao Gao, Jinlan Jiang
Purpose: Polydopamine-coated branched Au-Ag nanoparticles (Au-Ag@PDA NPs) exhibit good structural stability, biocompatibility, and photothermal performance, along with potential anticancer efficacy. Here, we investigated the cytotoxicity of Au-Ag@PDA NPs against human bladder cancer cells (T24 cells) in vitro and in vivo, as well as the underlying molecular mechanisms of photothermal therapy-induced T24 cell death. Materials and methods: T24 cells were treated with different doses of Au-Ag@PDA NPs followed by 808 nm laser irradiation, and the effects on cell proliferation, cell cycle, apoptosis, and autophagy were analyzed...
2018: International Journal of Nanomedicine
Víctor Manuel Díaz-García, Simón Guerrero, Natalia Díaz-Valdivia, Lorena Lobos-González, Marcelo Kogan, José Manuel Pérez-Donoso, Andrew Fg Quest
Background: Numerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in biological systems and little is known about whether QDs affect the capacity of cancer cells to metastasize. Previously, we described the "biomimetic" synthesis of CdTe-QDs (QDs-glutathione [GSH]) with increased biocompatibility and the potential utility in labeling cells...
2018: International Journal of Nanomedicine
Francis O Obiweluozor, Gladys A Emechebe, Arjun Prasad Tiwari, Ju Yeon Kim, Chan Hee Park, Cheol Sang Kim
Background: The objective of this study was to evaluate the efficacy of a combination of Photothermal therapy (PTT) and chemotherapy in a single nano-fiber platform containing lethal polydopamine nanopheres (PD NPs) for annihilation of CT 26 cancer cells. Method: Polydioxanone (PDO) nanofiber containing PD and bortezomib (BTZ) was fabricated via electrospinning method. The content of BTZ and PD after optimization was 7% and 2.5% respectively with respect to PDO weight...
2018: International Journal of Nanomedicine
Yong Zhang, Yongren Wang, Ru Wang, Yan Shen, Jing Xu, Thomas J Webster, Yongjun Fang
Purpose: PEGylated asparaginase (PEG-ASNase), which hydrolyzes asparagine to ammonia and aspartic acid, is an effective nanostructured antitumor agent for acute lymphoblastic leukemia (ALL). In order to monitor the activity of PEG-ASNase in plasma and design an individualization project, a rapid and sensitive method to determine PEG-ASNase activity in plasma using ultraviolet-visible spectrophotometry was established. Methods: PEG-ASNase is commonly used in acute lymphoblastic leukemia...
2018: International Journal of Nanomedicine
Sumaiyah Megat Nabil Mohsin, Mohd Zobir Hussein, Siti Halimah Sarijo, Sharida Fakurazi, Palanisamy Arulselvan, Yun Hin Taufiq-Yap
Introduction: The potential of layered double hydroxide (LDH) as a host of multiple ultraviolet-ray absorbers was investigated by simultaneous intercalation of benzophenone 4 (B4) and Eusolex® 232 (EUS) in Zn/Al LDH. Methods: The nanocomposites were prepared via coprecipitation method at various molar ratios of B4 and EUS. Results: At equal molar ratios, the obtained nanocomposite showed an intercalation selectivity that is preferential to EUS...
2018: International Journal of Nanomedicine
Tamás Mészáros, Gergely Tibor Kozma, Taro Shimizu, Koga Miyahara, Keren Turjeman, Tatsuhiro Ishida, Yechezkel Barenholz, Rudolf Urbanics, János Szebeni
Background: It has been proposed that many hypersensitivity reactions to nanopharmaceuticals represent complement (C)-activation-related pseudoallergy (CARPA), and that pigs provide a sensitive animal model to study the phenomenon. However, a recent study suggested that pulmonary hypertension, the pivotal symptom of porcine CARPA, is not mediated by C in cases of polystyrene nanoparticle (PS-NP)-induced reactions. Goals: To characterize PS-NPs and reexamine the contribution of CARPA to their pulmonary reactivity in pigs...
2018: International Journal of Nanomedicine
Osama Aa Ahmed, Shaimaa M Badr-Eldin
Background: Raloxifene hydrochloride (RLX) is approved by the US Food and Drug Administration for the treatment and prevention of osteoporosis, in addition to reducing the risk of breast cancer in postmenopausal women. RLX has the disadvantages of low aqueous solubility, extensive presystemic intestinal glucuronidation, and first-pass metabolism, resulting in a limited bio-availability of only 2%. The aim of this work was to enhance the bioavailability of RLX via the formulation of an in situ nasal matrix (misemgel) comprising micelles made of vitamin E and D-α-tocopheryl polyethylene glycol 1000 succinate and nanosized self-emulsifying systems (NSEMS)...
2018: International Journal of Nanomedicine
Shiva Ebrahimpour, Abolghasem Esmaeili, Siamak Beheshti
Background: Diabetes mellitus plays a causative role in cognitive decline. Newly, neuroprotective effects of flavonoids have been widely investigated in neurodegenerative diseases. Quercetin (QC) is a phyto-derived bioactive flavone with numerous beneficial activities. However, its limited permeability to cross the blood-brain barrier, low oral bioavailability, poor aqueous solubility, and rapid gastrointestinal digestion lead to the administration of high dose of QC in clinical application...
2018: International Journal of Nanomedicine
Wei Hong, Lipeng Liu, Zehui Zhang, Yining Zhao, Dexian Zhang, Mingchun Liu
Background: Multidrug-resistant (MDR) Streptococcus pneumonia constitute a major worldwide public health concern. Materials and methods: In our preliminary study, PEGylated nano-self-assemblies of bacitracin A (PEGylated Nano-BA12K ) showed strong antibacterial potency against reference S. pneumonia strain (ATCC 49619). In this study, the possibility of applying PEGylated Nano-BA12K against penicillin-resistant S. pneumonia was further investigated. In addition, the underlying antibacterial mechanism of PEGylated Nano-BA12K against both sensitive and resistant S...
2018: International Journal of Nanomedicine
Bingtao Zhai, Yiying Zeng, Zhaowu Zeng, Nana Zhang, Chenxi Li, Yijun Zeng, Yu You, Shuling Wang, Xiabin Chen, Xinbing Sui, Tian Xie
β-elemene is a noncytotoxic Class II antitumor drug extracted from the traditional Chinese medicine Curcuma wenyujin Y. H. Chen et C. Ling. β-elemene exerts its effects by inhibiting cell proliferation, arresting the cell cycle, inducing cell apoptosis, exerting antiangiogenesis and antimetastasis effects, reversing multiple-drug resistance (MDR), and enhancing the immune system. Elemene injection and oral emulsion have been used to treat various tumors, including cancer of the lung, liver, brain, breast, ovary, gastric, prostate, and other tissues, for >20 years...
2018: International Journal of Nanomedicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"