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International Journal of Nanomedicine

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https://www.readbyqxmd.com/read/28794631/surface-enhanced-raman-spectroscopy-of-serum-accurately-detects-prostate-cancer-in-patients-with-prostate-specific-antigen-levels-of-4-10-ng-ml
#1
Na Chen, Ming Rong, Xiaoguang Shao, Heng Zhang, Shupeng Liu, Baijun Dong, Wei Xue, Tingyun Wang, Taihao Li, Jiahua Pan
The surface-enhanced Raman spectroscopy (SERS) of blood serum was investigated to differentiate between prostate cancer (PCa) and benign prostatic hyperplasia (BPH) in males with a prostate-specific antigen level of 4-10 ng/mL, so as to reduce unnecessary biopsies. A total of 240 SERS spectra from blood serum were acquired from 40 PCa subjects and 40 BPH subjects who had all received prostate biopsies and were given a pathological diagnosis. Multivariate statistical techniques, including principal component analysis (PCA) and linear discriminant analysis (LDA) diagnostic algorithms, were used to analyze the spectra data of serum from patients in control (CTR), PCa and BPH groups; results offered a sensitivity of 97...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794630/probiotics-protect-mice-from-cocrmo-particles-induced-osteolysis
#2
Zhenheng Wang, Kaiwen Xue, Maosheng Bai, Zhantao Deng, Jingjing Gan, Gang Zhou, Hongbo Qian, Nirong Bao, Jianning Zhao
Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and immune system, leading to alterations in bone mass. Probiotic bacteria administered in adequate amounts can alter the composition of GM and confer health benefits to the host. Given the inflammatory osteolysis that occurs in wear debris-induced prosthesis loosening, we examined whether the probiotic Lactobacillus casei could reduce osteolysis in a mouse calvarial resorption model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794629/design-of-theranostic-nanomedicine-ii-synthesis-and-physicochemical-properties-of-a-biocompatible-polyphosphazene-docetaxel-conjugate
#3
Yong Joo Jun, Jung Hyun Park, Prakash G Avaji, Kyung Su Park, Kyung Eun Lee, Hwa Jeong Lee, Youn Soo Sohn
To prepare an efficient theranostic polyphosphazene-docetaxel (DTX) conjugate, a new drug delivery system was designed by grafting a multifunctional lysine ethylester (LysOEt) as a spacer group along with methoxy poly(ethylene glycol) (MPEG) to the polyphosphazene backbone ([NP]n), and then DTX was conjugated to the carrier polymer using acid-cleavable cis-aconitic acid (AA) as a linker. The resultant polyphosphazene-DTX conjugate, formulated as [NP(MPEG550)3(Lys-OEt)(AA)(DTX)]n and named "Polytaxel", exhibited high water solubility and stability by forming stable polymeric micelles as shown in its transmission electron microscopy image and dynamic light scattering measurements...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794628/a-synthetic-urinary-probe-coated-nanoparticles-sensitive-to-fibroblast-activation-protein-%C3%AE-for-solid-tumor-diagnosis
#4
Xinwei Feng, Qifan Wang, Yuehua Liao, Xie Zhou, Yidan Wang, Wanli Liu, Ge Zhang
We developed fibroblast activation protein α (FAPα)-sensitive magnetic iron oxide nanoparticles (MNPs) by conjugating a substrate-reporter tandem peptide as a synthetic biomarker to the surface of MNPs (marker-MNPs). In vitro, the marker-MNPs showed stability when treated with serum or urine and exhibited high susceptibility and specificity for FAPα enzyme and 3T3/FAPα cell line. Furthermore, the marker-MNPs were administered to esophageal squamous cell carcinoma xenograft tumor mice; they reached the tumor tissues in the mice, where they were cleaved effectively by the local overexpressed FAPα to release the reporter peptide and filter it into the urine...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794627/in-situ-imaging-of-quantum-dot-azd4547-conjugates-for-tracking-the-dynamic-behavior-of-fibroblast-growth-factor-receptor-3
#5
Gyoyeon Hwang, Hyeonhye Kim, Hojong Yoon, Chiman Song, Dong-Kwon Lim, Taebo Sim, Jiyeon Lee
Fibroblast growth factor receptors (FGFRs) play an important role in determining cell proliferation, differentiation, migration, and survival. Although a variety of small-molecule FGFR inhibitors have been developed for cancer therapeutics, the interaction between FGFRs and FGFR inhibitors has not been well characterized. The FGFR-inhibitor interaction can be characterized using a new imaging probe that has strong, stable signal properties for in situ cellular imaging of the interaction without quenching. We developed a kinase-inhibitor-modified quantum dot (QD) probe to investigate the interaction between FGFR and potential inhibitors...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794626/folic-acid-functionalized-polyethylenimine-superparamagnetic-iron-oxide-nanoparticles-as-theranostic-agents-for-magnetic-resonance-imaging-and-pd-l1-sirna-delivery-for-gastric-cancer
#6
Xin Luo, Xia Peng, Jingying Hou, Shuyun Wu, Jun Shen, Lingyun Wang
Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe3O4 nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794625/paclitaxel-loaded-and-a10-3-2-aptamer-targeted-poly-lactide-co-glycolic-acid-nanobubbles-for-ultrasound-imaging-and-therapy-of-prostate-cancer
#7
Meng Wu, Ying Wang, Yiru Wang, Mingbo Zhang, Yukun Luo, Jie Tang, Zhigang Wang, Dong Wang, Lan Hao, Zhibiao Wang
In the current study, we synthesized prostate cancer-targeting poly(lactide-co-glycolic acid) (PLGA) nanobubbles (NBs) modified using A10-3.2 aptamers targeted to prostate-specific membrane antigen (PSMA) and encapsulated paclitaxel (PTX). We also investigated their impact on ultrasound (US) imaging and therapy of prostate cancer. PTX-A10-3.2-PLGA NBs were developed using water-in-oil-in-water (water/oil/water) double emulsion and carbodiimide chemistry approaches. Fluorescence imaging together with flow cytometry verified that the PTX-A10-3...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28794624/nanostructured-delivery-systems-with-improved-leishmanicidal-activity-a-critical-review
#8
REVIEW
Natascia Bruni, Barbara Stella, Leonardo Giraudo, Carlo Della Pepa, Daniela Gastaldi, Franco Dosio
Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790823/a54-peptide-mediated-functionalized-gold-nanocages-for-targeted-delivery-of-dox-as-a-combinational-photothermal-chemotherapy-for-liver-cancer
#9
Shengnan Huang, Chunming Li, Weiping Wang, Huanjie Li, Zhi Sun, Chengzhi Song, Benyi Li, Shaofeng Duan, Yurong Hu
The combination of photothermal therapy and chemotherapy (photothermal-chemotherapy) is a promising strategy for cancer therapy. Gold nanocages (AuNCs), with hollow and porous structures and unique optical properties, have become a rising star in the field of drug delivery. Here, we designed a novel targeted drug delivery system based on functionalized AuNCs and evaluated their therapeutic effects in vitro and in vivo. We then loaded doxorubicin into this promising system, designated as DHTPAuNCs consisting of hyaluronic acid-grafted and A54 peptide-targeted PEGylated AuNCs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790822/complement-c3-dependent-uptake-of-targeted-liposomes-into-human-macrophages-b-cells-dendritic-cells-neutrophils-and-mdscs
#10
Alexandra Francian, Kristine Mann, Max Kullberg
Antitumor immunity in cancer patients is heavily modulated by cells of the innate immune system. Antigen-presenting cells, including dendritic cells, macrophages, and B cells, initiate immune recognition of tumor antigen by displaying antigen to effector cells. Countering this immune stimulation are immunosuppressive cells which include M2 macrophages, N2 neutrophils, and myeloid-derived suppressor cells (MDSCs). To create effective cancer immunotherapies, it is critical that we can target these important cell types of the immune system with immunostimulatory compounds...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790821/parallel-comparative-studies-on-toxicity-of-quantum-dots-synthesized-and-surface-engineered-with-different-methods-in-vitro-and-in-vivo
#11
Fengjun Liu, Wen Ye, Jun Wang, Fengxiang Song, Yingsheng Cheng, Bingbo Zhang
Quantum dots (QDs) have been considered to be promising probes for biosensing, bioimaging, and diagnosis. However, their toxicity issues caused by heavy metals in QDs remain to be addressed, in particular for their in vivo biomedical applications. In this study, a parallel comparative investigation in vitro and in vivo is presented to disclose the impact of synthetic methods and their following surface modifications on the toxicity of QDs. Cellular assays after exposure to QDs were conducted including cell viability assessment, DNA breakage study in a single cellular level, intracellular reactive oxygen species (ROS) receptor measurement, and transmission electron microscopy to evaluate their toxicity in vitro...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790820/effect-of-the-nanoformulation-of-sirna-lipid-assemblies-on-their-cellular-uptake-and-immune-stimulation
#12
Kohei Kubota, Kohei Onishi, Kazuaki Sawaki, Tianshu Li, Kaoru Mitsuoka, Takaaki Sato, Shinji Takeoka
Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs). In this study, we prepared small interfering RNA (siRNA)-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and evaluated the impact of structure on cellular uptake and immune stimulation. Lipoplexes are electrostatic complexes formed by mixing preformed cationic lipid liposomes with anionic siRNA in an aqueous environment, whereas LNPs are nanoparticles embedding siRNA prepared by mixing an alcoholic lipid solution with an aqueous siRNA solution in one step...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790819/kalopanacis-cortex-extract-capped-gold-nanoparticles-activate-nrf2-signaling-and-ameliorate-damage-in-human-neuronal-sh-sy5y-cells-exposed-to-oxygen-glucose-deprivation-and-reoxygenation
#13
Sun Young Park, Seon Yeong Chae, Jin Oh Park, Kyu Jin Lee, Geuntae Park
Recently, environment-friendly synthesis of gold nanoparticles (GNPs) has been extensively explored by biologists and chemists. However, significant research is still required to determine whether "eco-friendly" GNPs are beneficial to human health and to elucidate the molecular mechanisms of their effects on human cells. We used human neuronal SH-SY5Y cells to show that treatment with Kalopanacis Cortex extract-capped GNPs (KC-GNs), prepared via an eco-friendly, fast, one-pot synthetic route, protected neuronal cells against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced damage...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790818/peptide-modified-nanoparticles-inhibit-formation-of-porphyromonas-gingivalis-biofilms-with-streptococcus-gordonii
#14
Paridhi Kalia, Ankita Jain, Ranjith Radha Krishnan, Donald R Demuth, Jill M Steinbach-Rankins
PURPOSE: The interaction of Porphyromonas gingivalis with commensal streptococci promotes P. gingivalis colonization of the oral cavity. We previously showed that a synthetic peptide (BAR) derived from Streptococcus gordonii potently inhibited the formation of P. gingivalis/S. gordonii biofilms (IC50 =1.3 µM) and reduced P. gingivalis virulence in a mouse model of periodontitis. Thus, BAR represents a novel therapeutic to control periodontitis by limiting P. gingivalis colonization of the oral cavity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28769563/delivery-of-mir-375-and-doxorubicin-hydrochloride-by-lipid-coated-hollow-mesoporous-silica-nanoparticles-to-overcome-multiple-drug-resistance-in-hepatocellular-carcinoma
#15
Huiying Xue, Zhaoyang Yu, Yong Liu, Weigang Yuan, Tan Yang, Jia You, Xingxing He, Robert J Lee, Lei Li, Chuanrui Xu
Multidrug resistance (MDR) due to overexpression of P-glycoprotein (P-gp) is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). It has been shown that miR-375 inhibits P-gp expression via inhibition of astrocyte elevated gene-1 (AEG-1) expression in HCC, and induces apoptosis in HCC cells by targeting AEG-1 and YAP1. In this study, we prepared lipid-coated hollow mesoporous silica nanoparticles (LH) containing doxorubicin hydrochloride (DOX) and miR-375 (LHD/miR-375) to deliver the two agents into MDR HCC cells in vitro and in vivo...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28769562/mithramycin-loaded-mpeg-plga-nanoparticles-exert-potent-antitumor-efficacy-against-pancreatic-carcinoma
#16
Xu-Jie Liu, Liang Li, Xiu-Jun Liu, Yi Li, Chun-Yan Zhao, Rui-Qi Wang, Yong-Su Zhen
Previous studies have shown that mithramycin A (MIT) is a promising candidate for the treatment of pancreatic carcinoma through inhibiting transcription factor Sp1. However, systemic toxicities may limit its clinical application. Here, we report a rationally designed formulation of MIT-loaded nanoparticles (MIT-NPs) with a small size and sustained release for improved passive targeting and enhanced therapeutic efficacy. Nearly spherical MIT-NPs with a mean particle size of 25.0±4.6 nm were prepared by encapsulating MIT into methoxy poly(ethylene glycol)-block-poly(d,l-lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) with drug loading of 2...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28769561/nanoparticle-orientationally-displayed-antigen-epitopes-improve-neutralizing-antibody-level-in-a-model-of-porcine-circovirus-type-2
#17
Peiyang Ding, Teng Zhang, Yafei Li, Man Teng, Yaning Sun, Xiao Liu, Shujun Chai, Enmin Zhou, Qianyue Jin, Gaiping Zhang
Recent advancements in biotechnology have enabled the rapid identification and subsequent expression of pathogenic microbial major antigens that induce protective immune responses. However, subunit vaccines have not been successfully commercialized mainly due to the lack of sufficient levels of neutralizing antibodies (NAs). High levels of NA rely on the efficient recognition and cross-linking of multiple neutralizing epitopes with B-cell receptors (BCRs). Nanoparticles are able to display coupled antigenic arrays at high density and provide multiple binding molecular scenarios with BCRs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28769560/non-immunogenic-dextran-coated-superparamagnetic-iron-oxide-nanoparticles-a-biocompatible-size-tunable-contrast-agent-for-magnetic-resonance-imaging
#18
Harald Unterweger, Christina Janko, Marc Schwarz, László Dézsi, Rudolf Urbanics, Jasmin Matuszak, Erik Őrfi, Tamás Fülöp, Tobias Bäuerle, János Szebeni, Clément Journé, Aldo R Boccaccini, Christoph Alexiou, Stefan Lyer, Iwona Cicha
Iron oxide-based contrast agents have been in clinical use for magnetic resonance imaging (MRI) of lymph nodes, liver, intestines, and the cardiovascular system. Superparamagnetic iron oxide nanoparticles (SPIONs) have high potential as a contrast agent for MRI, but no intravenous iron oxide-containing agents are currently approved for clinical imaging. The aim of our work was to analyze the hemocompatibility and immuno-safety of a new type of dextran-coated SPIONs (SPIONdex) and to characterize these nanoparticles with ultra-high-field MRI...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28765708/folate-modified-annonaceous-acetogenins-nanosuspensions-and-their-improved-antitumor-efficacy
#19
Jingyi Hong, Zhonghao Sun, Yijing Li, Yifei Guo, Yonghong Liao, Meifeng Liu, Xiangtao Wang
Annonaceous acetogenins (ACGs) are a large family of fatty acid derived natural products that are exclusively isolated from the Annonaceae species. Many members of this diverse family have a broad spectrum of biological activities, the most impressive of which is anticancer activity. However, their poor solubility and severe toxicity restrict their clinical application, and their complicated composition hinders their formulation and drug delivery. In this study, β-cyclodextrin was modified with folic acid (FA) and then combined with soybean lecithin to prepare FA-modified ACGs nanosuspensions (FA-ACGs-NSps)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28765707/design-synthesis-and-evaluation-of-vegfr-targeted-macromolecular-mri-contrast-agent-based-on-biotin-avidin-specific-binding
#20
Yongjun Liu, Xiaoyun Wu, Xiaohe Sun, Dan Wang, Ying Zhong, Dandan Jiang, Tianqi Wang, Dexin Yu, Na Zhang
Developing magnetic resonance imaging (MRI) contrast agents with high relaxivity and specificity was essential to increase MRI diagnostic sensitivity and accuracy. In this study, the MRI contrast agent, vascular endothelial growth factor receptor (VEGFR)-targeted poly (l-lysine) (PLL)-diethylene triamine pentacetate acid (DTPA)-gadolinium (Gd) (VEGFR-targeted PLL-DTPA-Gd, VPDG), was designed and prepared to enhance the MRI diagnosis capacity of tumor. Biotin-PLL-DTPA-Gd was synthesized first, then, VEGFR antibody was linked to biotin-PLL-DTPA-Gd using biotin-avidin reaction...
2017: International Journal of Nanomedicine
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