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Journal of Burn Care & Research: Official Publication of the American Burn Association

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https://www.readbyqxmd.com/read/30649335/the-popliteal-keystone-island-flap-for-management-of-contracture-around-knee-joint-a-report-of-two-cases
#1
Mahmoud A Hifny
Introduction: Flexion contracture affecting the knee joint is considered a challenging obstacle which usually affects patients' quality of life with significant functional disability. Several surgical procedures have been described for proper closure of surgical defects following contracture release over popliteal fossa. Although keystone flap reported for closure of full thickness burns defects, to our knowledge, it has never been used previously in management of hypertrophic scar contracture around the knee joint...
January 14, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649358/effect-of-3-mercaptopyruvate-sulfurtransferase-deficiency-on-the-development-of-multiorgan-failure-inflammation-and-wound-healing-in-mice-subjected-to-burn-injury
#2
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
The gaseous transmitter hydrogen sulfide (H2S) has been implicated in various forms of critical illness. Here we have compared the outcome of scald burn injury in wild-type mice and in mice deficient in 3-mercaptopyruvate sulfurtransferase (3-MST), a mammalian H2S-generating enzyme. Outcome variables included indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. Plasma levels of H2S significantly increased in response to burn in wild-type mice, but remained unchanged in 3-MST-/- mice...
January 12, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649353/salvaging-the-zone-of-stasis-in-burns-by-pentoxifylline-an-experimental-study-in-rats
#3
Bora Yucel, Atilla Coruh, Kemal Deniz
Saving the zone of stasis is a major subject of the burn wound studies. If pathological changes in zone of stasis can be minimized, conversion of burns may be prevented. The aim of this study was to investigate the effects of pentoxifylline (PTX) on the zone of stasis in burns and burn wound healing. Twenty Sprague Dawley rats were used in this study. Comb model was used to create zone of stasis in burns. Rats were randomly divided into two groups. Treatment group received a total of 200 mg/kg/day of pentoxifylline in two equal doses intraperitoneally whilst isotonic saline solution was administered intraperitoneally to the control group...
January 12, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649454/cardiac-structure-and-function-in-well-healed-burn-survivors
#4
T Jake Samuel, Michael D Nelson, Aida Nasirian, Manall Jaffery, Gilbert Moralez, Steven A Romero, Matthew N Cramer, Mu Huang, Ken Kouda, Michinari Hieda, Satyam Sarma, Craig G Crandall
Long-term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. We therefore hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27...
January 10, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649382/self-inflicted-burn-injury-is-independently-associated-with-increased-mortality-in-a-more-economically-developed-country-a-propensity-score-matching-analysis
#5
Ryo Yamamoto, Takayuki Shibusawa, Tomohiro Kurihara, Junichi Sasaki
Self-inflicted burn accounts for considerable morbidity and mortality in more economically developed countries, and there is a substantial debate regarding the pathophysiological relevance between self-inflicted burns and unfavorable outcomes. To validate whether self-inflicted injury is an independent predictor of high mortality regardless of the severity of burn, we conducted a retrospective observational study using the Japan Trauma Data Bank, a nationwide database including over 200 major tertiary care centers...
January 10, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649378/matriderm-and-split-skin-grafting-for-full-thickness-paediatric-facial-burns
#6
Shane R Jackson, Sandrine Roman
Background: Facial burns remain a complex reconstructive challenge. Achieving the plastic surgical goals of restoring form and function is difficult in these cases, with poor cosmetic results, reduced facial animation, and oral and ocular contractures a common result. In recent years, the use of dermal substitutes in combination with skin grafts has shown promising results in complex burn reconstruction. Methods: A 3-year-old girl was admitted to our paediatric tertiary referral centre with 60% TBSA full-thickness burns, involving all skin above the waist including the face and neck...
January 9, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30649359/use-of-isokinetic-dynamometry-to-assess-muscle-function-in-burned-patients-is-a-reliable-tool-to-assist-progressive-resistance-exercise-prescription
#7
Julianna M Bores, Andrew J Murton, Shauna Q Glover, Ileana Gutierrez, Clark R Andersen, David N Herndon, Jong O Lee, Oscar E Suman
Isokinetic dynamometry is used during exercise testing and rehabilitation to obtain a quantitative strength measurement on which progressive strength training programs can be based. This study assesses the test-retest reliability of isokinetic leg function in the knee flexors and extensors at 150 degrees/second in children and young adults with severe burns to be used for rehabilitation exercise program prescription. In 39 severely burned patients (49 ± 14% total body surface area burn [TBSA], mean ± SD; 34 ± 21% TBSA 3 rd degree; 14 ± 5 years, 153...
January 9, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30500931/twenty-five-years-experience-and-beyond-with-cultured-epidermal-autografts-cea-for-coverage-of-large-burn-wounds-in-adult-and-pediatric-patients-1989-2015
#8
William L Hickerson, Ann E Remmers, David Recker
Objective: This report summarizes the characteristics of 954 burned patients treated with cultured epidermal autografts, the largest number of patients to date. Methods: Data collected include patient demographics, survival, and final graft take. Source data were provided by the treating physician or attending burn team. Safety data were provided by the treating physician, attending burn team and the pharmacovigilance database. Results: In this dataset collected between 1989 and 2015, 954 patients were treated with cultured epidermal autographs for burns...
November 30, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30452685/emergency-care-of-the-burn-patient-before-the-burn-center-a-systematic-review-and-meta-analysis
#9
Jamie Harshman, Mélissa Roy, Robert Cartotto
Background: Good burn care starts with correct management of the burn patient prior to transfer to a burn center. The purpose of this study was to perform a systematic review of the medical literature describing pre-burn center care. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for this review. Studies were included if they were published from a burn center and they measured or evaluated any aspect of pre-burn center care of adult or pediatric acute burn patients referred to that burn center...
November 19, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30445620/early-surgical-management-of-thermal-airway-injury-a-case-series
#10
Asitha Jayawardena, Anne S Lowery, Christopher Wootten, Gregory R Dion, J Blair Summitt, Stuart McGrane, Alexander Gelbard
Introduction: Inhalation injury is an independent risk factor in burn mortality, imparting a 20% increased risk of death. Yet there is little information on the natural history, functional outcome, or pathophysiology of thermal injury to the laryngotracheal complex, limiting treatment progress. Methods: Case series (n=3) of significant thermal airway injury. Results: In all cases, the initial injury was far exceeded by the subsequent immune response and aggressive fibro-inflammatory healing...
November 15, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30376104/impact-of-burn-related-amputations-on-return-to-work-findings-from-the-burn-injury-model-system-national-database
#11
Gretchen J Carrougher, Kara McMullen, Samuel P Mandell, Dagmar Amtmann, Karen J Kowalske, Jeffrey C Schneider, David N Herndon, Nicole S Gibran
Amputations following a burn injury, although infrequent, may impact community re-integration and create a barrier to returning to work. The objective of this study was to compare patient and injury characteristics, quality of life, and employment status for those with and without amputation using a national longitudinal database of people with burn injuries. In this retrospective review of prospectively collected data group differences were examined using descriptive statistics. We used linear and logistic regression models to identify factors significantly associated with amputation, factors associated with return to work rates, and SF-12 Physical (PCS) and Mental (MCS) Component Summary scores over time...
October 29, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30371792/the-use-of-a-brief-measure-to-assess-longitudinal-changes-in-appearance-concerns-for-youth-recovering-from-burn-injuries
#12
Valerie F Weed, Katia Canenguez, Stephanie Romo, Shirley L Wang, Lewis Kazis, Austin F Lee, David Herndon, Tina L Palmieri, Petra Warner, Haregnesh Haile, Robert L Sheridan, J Michael Murphy
Burns are among the most common injuries to children and, although survival rates have improved, many burn survivors are left with scars and/or other visible differences, which may be associated with anxiety, depression, and/or low self-esteem. A better understanding of the prevalence and persistence of these problems in child and adolescent burn survivors might lead to an expanded paradigm of care and possibly to better outcomes. The current study provides longitudinal prevalence data for the Appearance Concerns (AC) subscale of the parent-reported Burn Outcomes Questionnaire for 5-18 year olds and identifies patient characteristics associated with higher risk for appearance concerns...
October 29, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30371861/identification-of-cytochrome-p450-polymorphisms-in-burn-patients-and-impact-on-fentanyl-pharmacokinetics-a-pilot-study
#13
Kristin N Grimsrud, Xenia Ivanova, Catherine M Sherwin, Tina L Palmieri, Nam K Tran
Pain management is critical for burn care. Unfortunately, inter-individual variation in pharmacokinetics (PK) due to burn hypermetabolism and genetic polymorphisms can lead to treatment failures in this at-risk population. Aanalgesics may be affected by genetic polymorphisms affecting cytochrome P450 (CYP) drug metabolizing enzymes. Fentanyl is a common opiate primarily metabolized by CYP3A4 subtypes. Recent studies demonstrate CYP2D6 variants impacting fentanyl pharmacokinetics (PK). Functional CYP polymorphisms can significantly alter opiate levels resulting in inadequate analgesia or life-threatening toxicity...
October 27, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30371857/the-frequency-and-reason-for-amputations-in-electrically-burned-pediatric-patients
#14
Christian Tapking, Gabriel Hundeshagen, Daniel Popp, Jong O Lee, David N Herndon, Ramón Zapata-Sirvent, Ludwik K Branski
Electrical injuries induce substantial morbidity and mortality. Amputations are often necessary to enable survival and based on tissue non-viability, development of life threatening infection or expected non-functional outcome. We analyzed occurrence and type of amputations in our institution for electrical and non-electrical pediatric burns and the number of reconstructive operations. Patients who underwent any amputation between 1999 and 2017 were identified. Patients with electrical burns (EB) were matched regarding age, sex and percent total body surface area (%TBSA) burned to patients with non-electrical burns (NEB)...
October 27, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30365029/the-clinical-significance-of-serum-1-3-%C3%AE-d-glucan-for-the-diagnosis-of-candidemia-in-severe-burn-patients
#15
Yasuhiko Kaita, Takehiko Tarui, Akiyasu Otsu, Yuya Tanaka, Jun Suzuki, Kei Yoshikawa, Yoshihiro Yamaguchi
No abstract text is available yet for this article.
October 25, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30351404/current-trends-in-practice-for-early-mobility-with-the-burn-population
#16
Ingrid Parry, Soman Sen, Tina Palmieri, David Greenhalgh
There is a clinical trend toward "early mobilization" of patients with burn injury, however mobility is not well defined in burn care. Burn injuries result in various extents of injury, body areas affected, and types of skin graft surgeries needed-all of which may influence the type, timing, safety, and outcome of mobilization activities. This study surveyed burn clinicians to determine current mobility practices and the influence of skin graft surgery on clinical decisions to mobilize patients. A 32-question survey was electronically distributed to burn clinicians and included questions about postoperative range of motion (ROM) and out of bed (OOB) mobility practices for various skin graft types and locations...
October 22, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30481299/evaluation-of-procalcitonin-accuracy-for-the-distinction-between-gram-negative-and-gram-positive-bacterial-sepsis-in-burn-patients
#17
Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, João-Gonçalo Frade, Catarina Chaves, Marisa Caetano, Luís Almeida, José-Artur Paiva
Sepsis is the main cause of death in burns. Early institution of antimicrobial therapy is crucial to optimize outcomes but superfluous therapy increases adverse events, microbial resistance, and costs. Blood cultures are the gold standard for diagnosis but can take 48 to 72 hours. Biomarkers are used to help sepsis diagnosis and distinction between Gram-negative and Gram-positive bacterial cause. The aim of this work is to evaluate procalcitonin (PCT) accuracy for this distinction in burn patients. Retrospective observational study of adult septic burn patients with ≥15% total burn surface area admitted from January 2011 to December 2014 at a Burn Unit in Portugal...
January 1, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30107518/multiregional-utilization-of-a-mobile-device-app-for-triage-and-transfer-of-burn-patients
#18
Arek J Wiktor, Laura Madsen, Heather Carmichael, Tyler Smith, Shana Zanyk, Hamed Amani, Anne Lambert Wagner
Technology and telehealth have the potential to optimize burn care in areas limited by lack of expertise and geographic distance from a Burn Center. This study reports a multicenter, multiregional experience using a mobile phone app to facilitate triage of patients by allowing referring providers to send encrypted photos, thus enhancing the telephone consultation process. A retrospective review was conducted on referrals from August 2016 to July 2017 at three regional Burn Centers that utilize the same mobile phone app...
October 23, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30010999/the-long-term-impact-of-severe-burn-trauma-on-musculoskeletal-health
#19
Efstathia Polychronopoulou, David N Herndon, Craig Porter
Severe burn injury causes a profound stress response that leads to muscle and bone cachexia. Evidence suggests that these deficits persist for several months or even years after injury and are associated with growth delay, increased incidence of fractures, and increased hospital admissions for musculoskeletal disorders. Thus, there is an overwhelming need to determine the optimal acute and rehabilitative strategies to mitigate these deficits and improve quality of life for burn survivors. To date, there is limited research on the long-term impact of cachexia on functional performance and overall health, as well as on the lasting impact of pharmacological, nutritional, and exercise interventions...
October 23, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29931223/renal-replacement-therapy-in-severe-burns-a-multicenter-observational-study
#20
Kevin K Chung, Elsa C Coates, William L Hickerson, Angela L Arnold-Ross, Daniel M Caruso, Marlene Albrecht, Brett D Arnoldo, Christina Howard, Laura S Johnson, Melissa M McLawhorn, Bruce Friedman, Amy M Sprague, Michael J Mosier, David J Smith, Rachel A Karlnoski, James K Aden, Elizabeth A Mann-Salinas, Steven E Wolf
Acute kidney injury (AKI) after severe burns is historically associated with a high mortality. Over the past two decades, various modes of renal replacement therapy (RRT) have been used in this population. The purpose of this multicenter study was to evaluate demographic, treatment, and outcomes data among severe burn patients treated with RRT collectively at various burn centers around the United States. After institutional review board approval, a multicenter observational study was conducted. All adult patients aged 18 or older, admitted with severe burns who were placed on RRT for acute indications but not randomized into a concurrently enrolling interventional trial, were included...
October 23, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
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