Srinuvasu Nakka, Asif Raza, Kosana Sai Chaitanya, Naga Venkata Madhusudhan Rao Bandaru, Ala Chandu, Sankaranarayanan Murugesan, Nagaraju Devunuri, Arun K Sharma, Kondapalli Venkata Gowri Chandrasekhar
We designed and synthesized thirty novel quinoxaline aryl ethers as anticancer agents, and the structures of final compounds were confirmed with various analytical techniques like Mass, 1 H NMR, 13 C NMR, FTIR, and elemental analyses. The compounds were tested against three cancer cell lines: colon cancer (HCT-116), breast cancer (MDA-MB-231), prostate cancer (DU-145), and one normal cell line: human embryonic kidney cell line (HEK-293). The obtained results indicate that two compounds, FQ and MQ, with IC50 values < 16 μM, were the most active compounds...
March 2024: Chemical Biology & Drug Design