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Acta Physiologica

Neta Tuvia, Pontus B Persson, Anja B Persson
Have you ever felt socially jet lagged? Running out of time? Or that everyone around you just keeps running late? If the answer is yes, this might not only be your subjective feeling, but rather a measurable outcome in a society comprising young and old, owls and larks, and all of them with clocks running in different periods, phases and amplitudes. This article is protected by copyright. All rights reserved.
October 14, 2016: Acta Physiologica
Aaron P Russell, Marita A Wallace, Ming Kalanon, Evelyn Zacharewicz, Paul A Della Gatta, Andrew Garnham, Séverine Lamon
AIM: The striated muscle activator of Rho signalling (STARS) is a muscle-specific actin-binding protein. The STARS signalling pathway is activated by resistance exercise and is anticipated to play a role in signal mechanotransduction. Animal studies have reported a negative regulation of STARS signalling with age, but such regulation has not been investigated in humans. METHODS: Ten young (18-30 years) and 10 older (60-75 years) subjects completed an acute bout of resistance exercise...
October 14, 2016: Acta Physiologica
P B Persson
My tailor suggests I should dress for the body I have, not for the body I want. Conversely, Acta Physiologica's lean and muscular build calls for streamlining her appearance. Over the latest years, Acta Physiologica has been ranked highly among the physiology journals.(1,2) Our readers have increasingly downloaded our articles, and many more manuscripts have been submitted year-by-year.(3-5) Reflecting these changes, more persons read Acta Physiologica out of general interest, and not only to stay on top of their fields...
October 11, 2016: Acta Physiologica
X-Y Feng, D-N Zhang, Y-A Wang, R-F Fan, F Hong, Y Zhang, Y Li, J-X Zhu
AIM: The intestinal barrier is made up of epithelial cells and intercellular junctional complexes to regulate epithelial ion transport and permeability. Dopamine (DA) is able to promote duodenal epithelial ion transport through D1-like receptors, which includes subtypes of D1 (D1 R) and D5 (D5 R), but whether D1-like receptors influence the duodenal permeability is unclear. METHODS: FITC-dextran permeability, short-circuit current (ISC ), Western blot, immunohistochemistry and ELISA were used in human D5 R transgenic mice and hyperendogenous enteric DA (HEnD) rats in this study...
October 6, 2016: Acta Physiologica
Premraj Rajkumar, Jennifer L Pluznick
Recent studies have shown that orphan GPCRs of the GPR family are utilized as specialized chemosensors in various tissues to detect metabolites, and in turn to activate downstream pathways which regulate systemic homeostasis. These studies often find that such metabolites are generated by well-known metabolic pathways, implying that known metabolites and chemicals may perform novel functions. In this review, we summarize recent findings highlighting the role of deorphanized GPRs in renal development and function...
October 3, 2016: Acta Physiologica
M Fähling, S Mathia, J Scheidl, R Abramovitch, Z Milman, A Paliege, H Peters, P B Persson, S N Heyman, C Rosenberger
AIM: Cyclosporin A (CsA) causes renal toxicity. The underlying mechanisms are incompletely understood, but may involve renal hypoxia and hypoxia-inducible factors (Hifs). We sought for hypoxia and Hif in mouse kidneys with CsA-induced toxicity, assessed their time course, Hif-mediated responses and the impact of interventional Hif upregulation. METHODS: Mice received CsA or its solvent cremophore for up to 6 weeks. Low salt diet (Na(+) ↓) was given in combination with CsA to enhance toxicity...
September 30, 2016: Acta Physiologica
Jin Yu, Yiliyaer Maimaitili, Peng Xie, Jianjiang Wu, Jiang Wang, Yining Yang, Haiping Ma, Hong Zheng
AIM: Hyperglycaemia-induced cell injury is a primary cause of cardiovascular complications in diabetic patients. In vivo studies demonstrated that sevoflurane postconditioning (SpostC) was cardioprotective against ischaemia/reperfusion injury, which was blocked by hyperglycaemia. This study investigated whether high glucose concentration abrogated SpostC cardioprotection in vitro by advancing mitochondrial fission and whether mitochondrial division inhibitor-1 (Mdivi-1) restored SpostC cardioprotection in cultured primary neonatal rat cardiomyocytes (NCMs)...
September 29, 2016: Acta Physiologica
R Schubert
No abstract text is available yet for this article.
September 28, 2016: Acta Physiologica
Y Onetti, A P Dantas, B Pérez, A J McNeish, E Vila, F Jiménez-Altayó
AIM: Increased thromboxane A2 and peroxynitrite are hallmarks of cerebral ischaemia/reperfusion (I/R). Stimulation of thromboxane/prostaglandin receptors (TP) attenuates endothelium-derived hyperpolarization (EDH). We investigated whether EDH-type middle cerebral artery (MCA) relaxations following TP stimulation are altered after I/R and the influence of peroxynitrite. METHODS: Vascular function was determined by wire myography after TP stimulation with the thromboxane A2 mimetic 9,11-dideoxy-9α, 11α -methano-epoxy prostaglandin F2α (U46619) in MCA of Sprague Dawley rats subjected to MCA occlusion (90 min)/reperfusion (24 h) or sham operation, and in non-operated (control) rats...
September 28, 2016: Acta Physiologica
R Terp, H B Mieritz, P B L Hansen
No abstract text is available yet for this article.
September 21, 2016: Acta Physiologica
Y-A Kuhn, M Keller, J Ruffieux, W Taube
AIM: Although it is well established that an external (EF) compared to an internal (IF) or neutral focus of attention enhances motor performance, little is known about the underlying neural mechanisms. This study aimed to clarify whether the focus of attention influences not only motor performance but also activity of the primary motor cortex (M1) when executing identical fatiguing tasks of the right index finger (first dorsal interosseous). Transcranial magnetic stimulation (TMS) at intensities below motor threshold was applied over M1 to assess and compare the excitability of intracortical inhibitory circuits...
September 21, 2016: Acta Physiologica
Harold A Coleman, Marianne Tare, Helena C Parkington
In a number of published studies on endothelium-dependent hyperpolarization and relaxation, the results of the effects of K(+) blockers have been difficult to interpret. When the effects of two blockers have been studied, often either blocker by itself had little effect, whereas the two blockers combined tended to abolish the responses. Explanations suggested in the literature include an unusual pharmacology of the K(+) channels, and possible blocker binding interactions. In contrast, when we applied the same blockers to segments of small blood vessels under voltage-clamp, the blockers reduced the endothelium-dependent K(+) current in a linearly additive manner...
September 17, 2016: Acta Physiologica
K Solocinski, M Holzworth, X Wen, K-Y Cheng, I J Lynch, B D Cain, C S Wingo, M L Gumz
AIM: Increasing evidence demonstrates that circadian clock proteins are important regulators of physiological functions including blood pressure. An established risk factor for developing cardiovascular disease is the absence of a blood pressure dip during the inactive period. The goal of the present study was to determine the effects of a high salt diet plus mineralocorticoid on PER1-mediated blood pressure regulation in a salt-resistant, normotensive mouse model, C57BL/6J. METHODS: Blood pressure was measured using radiotelemetry...
September 16, 2016: Acta Physiologica
J Su, O Hilberg, L Howard, U Simonsen, A D Hughes
Mean pulmonary arterial pressure and pulmonary vascular resistance (PVR) remain the most common haemodynamic measures to evaluate the severity and prognosis of pulmonary hypertension. However, PVR only captures the non-oscillatory component of the right ventricular hydraulic load and neglects the dynamic compliance of the pulmonary arteries and the contribution of wave transmission. Wave intensity analysis offers an alternative way to assess the pulmonary vasculature in health and disease. Wave speed is a measure of arterial stiffness, and the magnitude and timing of wave reflection provide information on the degree of impedance mismatch between the proximal and distal circulation...
September 16, 2016: Acta Physiologica
G Stölting, C Fahlke
No abstract text is available yet for this article.
September 16, 2016: Acta Physiologica
J You, Z Yue, S Chen, Y Chen, X Lu, X Zhang, P Shen, J Li, Q Han, Z Li, P Liu
AIM: The transcriptional cofactor receptor-interacting protein 140 (RIP140) is known as a deleterious regulator of cardiac mitochondrial function and energy metabolic homeostasis. This study revealed that RIP140 repressed Sirtuin 3 (SIRT3), a mitochondrial deacetylase that plays an important role in regulating cardiac function. METHODS: RIP140 was overexpressed by adenovirus infection or was knocked down by RNA interference in neonatal rat cardiomyocytes. RESULTS: RIP140 overexpression repressed, while RIP140 silencing elevated the expression and activity of SIRT3...
September 10, 2016: Acta Physiologica
J Bełtowski
No abstract text is available yet for this article.
September 8, 2016: Acta Physiologica
S B Anderberg, T Luther, R Frithiof
Sepsis-induced acute kidney injury (SI-AKI) is common and associated with high mortality. Survivors are at increased risk of chronic kidney disease. The precise mechanism underlying SI-AKI is unknown, and no curative treatment exists. Toll-like receptor 4 (TLR4) activates the innate immune system in response to exogenous microbial products. The result is an inflammatory reaction aimed at clearing a potential infection. However, the consequence may also be organ dysfunction as the immune response can cause collateral damage to host tissue...
September 7, 2016: Acta Physiologica
D R Slivka
No abstract text is available yet for this article.
September 2, 2016: Acta Physiologica
P Anegroaie, M G Frasch, S Rupprecht, I Antonow-Schlorke, T Müller, H Schubert, O W Witte, M Schwab
AIM: Antenatal glucocorticoids are used to accelerate foetal lung maturation in babies threatened with premature labour. We examined the influence of glucocorticoids on functional and structural maturation of the central somatosensory pathway in foetal sheep. Somatosensory-evoked potentials (SEP) reflect processing of somatosensory stimuli. SEP latencies are determined by afferent stimuli transmission while SEP amplitudes reveal cerebral processing. METHODS: After chronic instrumentation of foetal sheep, mothers received saline (n = 9) or three courses of betamethasone (human equivalent dose of 2 × 110 μg kg(-1) betamethasone i...
September 1, 2016: Acta Physiologica
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