Tilman Pfeffer, Susanne M Krug, Tamara Kracke, Robin Schürfeld, Florian Colbatzky, Philip Kirschner, Rebekka Medert, Marc Freichel, Dagmar Schumacher, Maria Bartosova, Sotiris G Zarogiannis, Martina U Muckenthaler, Sandro Altamura, Silvia Pezer, Nadine Volk, Constantin Schwab, Stefan Duensing, Thomas Fleming, Elena Heidenreich, Johannes Zschocke, Rüdiger Hell, Gernot Poschet, Claus P Schmitt, Verena Peters
AIM: Although of potential biomedical relevance, dipeptide metabolism has hardly been studied. We found the dipeptidase carnosinase-2 (CN2) to be abundant in human proximal tubules, which regulate water and solute homeostasis. We therefore hypothesized, that CN2 has a key metabolic role, impacting proximal tubular transport function. METHODS: A knockout of the CN2 gene (CNDP2-KO) was generated in human proximal tubule cells and characterized by metabolomics, RNA-seq analysis, paracellular permeability analysis and ion transport...
March 22, 2024: Acta Physiologica