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Acta Physiologica

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https://www.readbyqxmd.com/read/28888077/microrna-214-3p-a-link-between-autophagy-and-endothelial-cell-dysfunction-in-atherosclerosis
#1
Jing Wang, Wei-Na Wang, Shuang-Bin Xu, Hong Wu, Bing Dai, Dong-Dong Jian, Mei Yang, Yu-Tao Wu, Qiang Feng, Jian-Hua Zhu, Lei Zhang, Li Zhang
AIM: Endothelial cell injury assumes a fundamental part in the pathogenesis of atherosclerosis, and endothelial cell autophagy has protective effects on the development of atherosclerosis, though the underlying molecular regulation mechanism is indistinct. This study is aimed to investigate whether microRNA-214-3p (miR-214-3p) is involved in the endothelial cell autophagy regulation of atherosclerosis. METHODS: We utilized ApoE-/- mice provided with a high-fat diet (HFD) as atherosclerosis model...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28888063/sumo-co-expression-modifies-kv-11-1-channel-activity
#2
Annette Buur Steffensen, Martin Nybo Andersen, Nancy Mutsaers, Amer Mujezinovic, Nicole Schmitt
AIM: The voltage-gated potassium channel KV 11.1 is the molecular basis for the IKr current which plays an important role in cardiac physiology. Its malfunction is associated with both inherited and acquired cardiac arrhythmias. Native currents differ from those in experimental models, suggesting additional regulatory mechanisms. We hypothesised that the post-translational modification sumoylation finetunes channel activity. METHODS: The functional effects of sumoylation on KV 11...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28887908/top-scorers-of-2015
#3
EDITORIAL
P B Persson
Over 25% of the articles published in 2015 received double digit citations. Not surprisingly, slightly more than half of our reviews published in Acta Physiologica exceed this citation level. Obviously, Acta Physiologica is on the rise and attracts ever more readers. It is with satisfaction that we discovered that this high-quality is distributed throughout all fields published in Acta Physiologica. This article is protected by copyright. All rights reserved.
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28887906/sphingosine-1-phosphate-and-renal-vasoconstriction
#4
EDITORIAL
Boye L Jensen
In the present issue of Acta Physiologica, Guan et al. in their article "Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles" (1) address the signaling events associated with sphingosine-1-phosphate (S1P)-mediated renal afferent vasoconstriction and show in, technically demanding, blood-perfused juxtamedullary nephron preparation that S1P signaling relies predominantly on transmembrane calcium influx from the extracellular fluid through L-type calcium channels with contribution from oxidative stress metabolites(1) ...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28887887/evaluating-the-essential-role-of-rons-in-vivo-in-exercised-human-muscle
#5
EDITORIAL
Enrique Jaimovich, Mariana Casas
An article by Margaritelis et al.,(1) (this issue) addresses an important issue in exercise physiology, as it is the actual role of reactive oxygen and nitrogen species (RONS) in exercise-induced adaptations in humans. The authors designed a procedure that allowed them to avoid the use of exogenous anti-oxidants and redox agents that will normally alter metabolism and have multiple undesired effects. We discuss here in the context of the necessary balance between the beneficial role of reactive oxygen and nitrogen species as intracellular signals for muscle adaptation and the deleterious effects of these species in oxidative stress...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28872781/armax-a-method-for-assessment-of-the-dynamic-response-of-the-arterial-baroreflex
#6
Morten T Lund, Max Salomonsson, Thomas E N Jonassen, Niels-Henrik Holstein-Rathlou
AIM: The baroreflex is a key mechanism in cardiovascular regulation and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analyzing baroreceptor function from continuous blood pressure and heart rate in both health and disease. METHODS: 48-hour data series of blood pressure and heart rate were collected with telemetry. Sprague-Dawley rats on standard chow (n=11) served as controls, while rats on a high-fat, high-fructose diet (n=6) constituted the obese-hypertensive model...
September 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28872777/orexin-a-increases-sympathetic-nerve-activity-through-promoting-expression-of-proinflammatory-cytokines-in-sprague-dawley-rats
#7
Yuanyuan Fan, Enshe Jiang, Taija Hahka, Qinghui Chen, Jianqun Yan, Zhiying Shan
AIM: Accumulating evidence suggests that orexin signaling is involved in the regulation of blood pressure and cardiovascular function. However, the underlying mechanisms are not clear. Here we test the hypothesis that upregulated orexin A signaling in the paraventricular nucleus (PVN) increases sympathetic nerve activity (SNA) through stimulating expression of proinflammatory cytokines (PICs). METHODS: In vivo sympathetic nerve recordings were performed to test the impact of PVN orexin signaling on sympathetic outflow in Sprague-Dawley (SD) rats...
September 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834354/trpm5-in-the-battle-against-diabetes-and-obesity
#8
REVIEW
Rudi Vennekens, Margot Mesuere, Koenraad Philippaert
TRPM5 is a nonselective monovalent cation channel activated by increases of intracellular Ca(2+) . It has a distinct expression pattern: expression is detected in chemosensitive tissues from solitary chemosensory cells to the taste receptor cells and in pancreatic β-cells. The role of TRPM5 has been investigated with the use of knockout mouse models. Trpm5(-/-) mice have a lack of type II taste perception and show reduced glucose-induced insulin secretion. Expression levels of TRPM5 are reduced in obese, leptin signaling deficient mice and mutations in TRPM5 have been associated with type II diabetes and metabolic syndrome...
August 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834306/arginase-a-novel-target-for-cardioprotection-by-vagal-nerve-stimulation
#9
EDITORIAL
A Uitterdijk, D J Duncker
The elegant study of Kiss et al.(1) in this issue of Acta Physiologica entitled 'Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha-7 nicotinic acetylcholine receptor and down-regulation of cardiac and vascular arginase' explores the role of arginase in myocardial ischemia-reperfusion damage, and in the myocardial infarct-size limitation by vagal nerve stimulation. This article is protected by copyright. All rights reserved.
August 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834278/contribution-of-mitochondria-derived-free-radicals-to-endothelial-dysfunction-in-human-skeletal-muscle-feed-arteries-another-hazard-of-the-aging-process
#10
EDITORIAL
Julian H Lombard
Earlier studies by a number of laboratories (1-3) have demonstrated impaired endothelium-dependent vasodilation in arterioles of aged animals and humans; and older humans exhibit significantly attenuated hyperemic responses to moderate exercise(1) and endothelium-dependent vasodilator stimuli (3) compared to younger controls, emphasizing the need for carefully targeted research to understand the mechanisms underlying compromised blood flow with age and its consequences. The current paper by Park and coworkers(4) is a follow-up to an earlier study by this group,(3) in which they demonstrated a significant attenuation of endothelium-dependent dilation in older subjects, compared to young subjects, which was accompanied by reductions in phospho-eNOS/eNOS (p-eNOS/eNOS) ratio and elevations in vascular superoxide (O2(-) ) levels...
August 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834248/high-doses-of-anti-inflammatory-drugs-compromise-muscle-strength-and-hypertrophic-adaptations-to-resistance-training-in-young-adults
#11
Mats Lilja, Mirko Mandić, William Apró, Michael Melin, Karl Olsson, Staffan Rosenborg, Thomas Gustafsson, Tommy R Lundberg
AIMS: This study tested the hypothesis that high doses of anti-inflammatory drugs would attenuate the adaptive response to resistance training compared with low doses. METHODS: Healthy men and women (aged 18-35 years) were randomly assigned to daily consumption of ibuprofen (IBU; 1200 mg; n=15) or acetylsalicylic acid (ASA; 75 mg; n=16) for 8 weeks. During this period, subjects completed supervised knee-extensor resistance training where one leg was subjected to training with maximal volitional effort in each repetition using a flywheel ergometer (FW), while the other leg performed conventional (work-matched across groups) weight-stack training (WS)...
August 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834378/autophagic-dysfunction-and-autophagosome-escape-in-the-mdx-mus-musculus-model-of-duchenne-muscular-dystrophy
#12
Hannah R Spaulding, Ellen M Kelly, John C Quindry, Joel B Sheffield, Matthew B Hudson, Joshua T Selsby
AIM: Duchenne muscular dystrophy is caused by the absence of functional dystrophin protein and results in a host of secondary effects. Emerging evidence suggests that dystrophic pathology includes decreased pro-autophagic signaling and suppressed autophagic flux in skeletal muscle, but the relationship between autophagy and disease progression is unknown. The purpose of this investigation was to determine the extent to which basal autophagy changes with disease progression. We hypothesized that autophagy impairment would increase with advanced disease...
August 19, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28834376/nephropathies
#13
EDITORIAL
Anika Westphal, Stefanie Reuter, Ralf Mrowka
Origins and progresses of nephropathies are manifold and include inflammatory or non-inflammatory causes. The incidence of nephropathies increases all over the world, supported by the growing elderly population. Nowadays there are about two million fatalities per year due to acute kidney injury (AKI) (1) . Clinical outcomes of AKI have not improved over the past 50 years (2) . Renal tissue hypoperfusion and hypoxia are thought to be the main elements causing AKI and the progression to chronic kidney disease (CKD) and end stage renal disease (ESRD) (1) ...
August 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28795790/borders-and-beyond
#14
EDITORIAL
P B Persson, Anja Bondke Persson
Compartmentalization is a basic requirement of life on earth. Eukaryotic cells separate themselves from their surroundings by biological membranes which function as intricately regulated barriers. These borders, at best, allow e.g. intercellular communication and transport. They ensure that intruders are kept outside, that supplies are coming in and products are exported and that waste is got rid of, all in due time and amount. Cell membranes protect the cell and organize its functionality. That is a far as the ideal situation goes...
August 10, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28792670/comments-on-the-review-biomarkers-in-acute-kidney-injury-pathophysiological-basis-and-clinical-performance-acta-physiol-2017-219-556-574-an-update-on-kidney-localization-of-igfbp7-and-timp2
#15
David R Emlet, Xiaoyan Wen, John A Kellum
In March of 2017, Acta Physiologica published a special series on renoprotection, and one of the publications in that series was a review entitled "Biomarkers in acute kidney injury - pathophysiological basis and clinical performance". This review described very well the current understanding of the pathophysiology, cellular localization, and clinical performance of the most important currently proposed biomarkers of AKI, to include insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases 2 (TIMP2)...
August 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28786555/study-of-termination-of-postprandial-gastric-contractions-in-humans-dogs-and-suncus-murinus-role-of-motilin-and-ghrelin-induced-strong-contraction
#16
Takashi Mikami, Kazuma Ito, Hetzel Tartera Diaz, Per M Hellström, Erito Mochiki, Shota Takemi, Toru Tanaka, Sachiko Tsuda, Takamichi Jogahara, Ichiro Sakata, Takafumi Sakai
AIM: Stomach contractions show two types of specific patterns in many species, i.e., migrating motor contraction (MMC) and postprandial contractions (PPCs), in the fasting and fed state, respectively. We found gastric PPCs terminated with migrating strong contractions in humans, dogs, and suncus. In this study, we reveal the detailed characteristics and physiological implications of these strong contractions of PPC. METHODS: Human, suncus, and canine gastric contractions were recorded with a motility-monitoring ingestible capsule and a strain-gauge force transducer...
August 8, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28771989/the-importance-of-the-functional-network-between-endothelial-microparticles-and-late-endothelial-progenitor-cells-for-understanding-the-physiological-aspects-of-this-new-vascular-repair-system
#17
EDITORIAL
Rosita A Condorelli, Aldo E Calogero, Sandro La Vignera
The article by Alexandru and colleagues, entitled "Microparticles of healthy origins improves endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model", represent an important advance in the physiology of the late endothelial progenitor cells (EPCs), documenting the complementary role played by endothelial microparticles (MPs) that play an active role in this repair system. This article is protected by copyright. All rights reserved.
August 3, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28771943/overexpression-of-integrin-%C3%AE-11-induces-cardiac-fibrosis-in-mice
#18
Andreas Romaine, Ida W Sørensen, Cédric Zeltz, Ning Lu, Pugazendhi Murugan Erusappan, Arne Olav Melleby, Lili Zhang, Bård Bendiksen, Emma Louise Robinson, Jan Magnus Aronsen, Kate M Herum, Håvard Danielsen, Ivar Sjaastad, Geir Christensen, Donald Gullberg
AIM: To understand the role of the collagen-binding integrin α11 in vivo we have used a classical approach of creating a mouse strain overexpressing integrin α11. A transgenic mouse strain overexpressing α11 in muscle tissues was analysed in the current study with special reference to the heart tissue. METHODS: We generated and phenotyped integrin α11 transgenic (TG) mice by echocardiography, magnetic resonance imaging and histology. Wild-type (WT) mice were subjected to aortic banding (AB) and the expression of integrin α11 was measured in flow cytometry sorted cardiomyocytes and non-myocytes...
August 3, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28763156/distribution-of-muscle-fiber-conduction-velocity-for-representative-samples-of-motor-units-in-the-full-recruitment-range-of-the-tibialis-anterior-muscle
#19
Alessandro Del Vecchio, Francesco Negro, Francesco Felici, Dario Farina
AIM: Motor units are recruited in an orderly manner according to the size of motor neurons. Moreover, because larger motor neurons innervate fibers with larger diameters than smaller motor neurons, motor units should be recruited orderly according to their conduction velocity (MUCV). Because of technical limitations, these relations have been previously tested either indirectly or in small motor unit samples that revealed weak associations between motor unit recruitment threshold (RT) and MUCV...
August 1, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28752608/different-solutions-to-restoring-oxygen-delivery-at-altitude
#20
EDITORIAL
William K Milsom
Populations resident to high altitude have adapted to the demands of performance in low oxygen environments in different ways. The article by Ivy et al.(1) provides new data allowing the authors to speculate on what specifically may have led to these alternate solutions. This article is protected by copyright. All rights reserved.
July 28, 2017: Acta Physiologica
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