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Acta Physiologica

Louis-Solal Giboin, Benjamin Weiss, Felix Thomas, Markus Gruber
AIMS: Different modalities of strength training cause performance enhancements, which are specific for the trained task. However, the involved mechanisms are still largely unknown. It has been demonstrated that strength training could induce neuroplasticity, which might underlie the performance improvements during the first training sessions. Thus, we hypothesized to find task-specific neuroplasticity after a short-term strength training of two distinct strength tasks. METHODS: Young healthy male subjects were exposed to 4 sessions of either maximal isometric explosive (EXPL group, N = 9) or slow sustained (SUS group, N = 10) knee extensions...
November 16, 2017: Acta Physiologica
Adriana Georgescu
The original article by Jing Wang and collaborators, entitled "MicroRNA-214-3p: A Link between Autophagy and Endothelial Cell Dysfunction in Atherosclerosis", brings new data concerning molecular mechanisms linking decreased autophagy to endothelial dysfunction in atherosclerosis. In this issue of Acta Physiologica, the authors concluded that microRNA-214-3p (miR-214-3p) controls oxidized low-density lipoprotein (ox-LDL)-induced autophagy in human umbilical vein endothelial cells (HUVECs) by regulating intracellular levels of autophagy-related protein 5 (ATG5), and may have a relevant role in the pathogenesis of atherosclerosis...
November 16, 2017: Acta Physiologica
Roger G Evans, Yugeesh R Lankadeva, Andrew D Cochrane, Bruno Marino, Naoya Iguchi, Michael Z L Zhu, Sally G Hood, Julian A Smith, Rinaldo Bellomo, Bruce S Gardiner, Chang-Joon Lee, David W Smith, Clive N May
Acute kidney injury (AKI) is a common complication following cardiac surgery performed on cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology of cardiac surgery-associated AKI is complex, but renal hypoxia, particularly in the medulla, is thought to play at least some role. There is strong evidence from studies in experimental animals, clinical observations and computational models, that medullary ischaemia and hypoxia occurs during CPB. There are no validated methods to monitor or improve renal oxygenation during CPB, and thus possibly decrease the risk of AKI...
November 11, 2017: Acta Physiologica
K-E Andersson
In this issue of Acta Physiologica, Kullmann et al. examined the morphology and potential role in sensory signaling of a different class of specialized cells in mouse urethral epithelium that express serotonin (5-HT), termed paraneurons.(1) They propose that the paraneurons function as important detectors and transmitters in the urethral sensory mechanisms. Signalling from the afferent nerves of the lower urinary tract (LUT) is required for sensation of pain, bladder filling, and initiation and maintenance of the micturition reflex...
November 9, 2017: Acta Physiologica
Ewa Zalewska, Malgorzata Gawel
Single-fiber electromyography (SFEMG) is one of the most important diagnostic tools for evaluating neuromuscular transmission and jitter as well as fiber density.(1) When a motor axon is depolarized, the action potential travels distally and activates all the muscle fibers belonging to the same motor unit at more or less the same time. The variations in the time interval between firing of adjacent single muscle fibers from the same motor unit are called neuromuscular jitter and reflect abnormalities in the transmission time in axonal derivations and synapses...
November 9, 2017: Acta Physiologica
P B Persson
This editorial may have remained unwritten, in the face of a lifetime word cap for scientists, which is regaining interest. (Give researchers a lifetime word limit, Brian C. Martinson, Nature).Providing us with a lifespan contingent of words for our scientific writing immediately solves many present-day glitches. No more minimal-publishing-units and redundant material will flood journals or aggravate reviewers. This article is protected by copyright. All rights reserved.
November 8, 2017: Acta Physiologica
Brad Schoenfeld
In this issue of Acta Physiologica, Lilja et al. (1) provide novel insights into the effects of consuming high-doses of non-steroidal anti-inflammatory drugs (NSAIDs) on exercise-induced muscular adaptations. NSAIDs are routinely administered to relieve symptoms associated with delayed onset muscle soreness (DOMS) and restore normal physical function following intense physical activity. Millions worldwide report the daily intake of NSAIDS, and their usage is especially common in athletes and those who partake in rigorous exercise (2) ...
November 8, 2017: Acta Physiologica
Ana Clara Najenson, Ana Paula Courreges, Juan Carlos Perazzo, María Fernanda Rubio, Marcelo S Vatta, Liliana G Bianciotti
AIM: We previously reported that atrial natriuretic peptide (ANP) reduces serum amylase and intrapancreatic trypsinogen activation in the onset of acute pancreatitis whereas secretin increases them. In the present work, we sought to establish the effect of ANP and secretin on the inflammatory response and cell death in experimental acute pancreatitis. METHODS: The expression and activity of key inflammatory mediators and apoptosis were evaluated in the presence or absence of the atrial peptide, secretin or both in cerulein-induced acute pancreatitis in rats...
November 8, 2017: Acta Physiologica
Helene Rundqvist, Thomas Gustafsson
Despite decades of research and numerous studies, the evidence supporting altitude adaptation for lowlanders who intend to perform at or around sea level is still under debate. In a recent study, Girard and colleagues aimed to complement the general consensus that the "live high-train low" is the most advantageous regime by adding either normoxic (LHTL) or hypoxic (LHTLH) repeated sprint sessions to improve team-athlete performance. This article is protected by copyright. All rights reserved.
October 31, 2017: Acta Physiologica
Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider
Recent recognition that mobile pools of Zn(2+) and Cu(2+) are involved in the regulation of neuronal, endocrine and other cells has stimulated the development of tools to visualize and quantify the level of free trace metal ions. Most of the methods used to measure or control loosely bound metals require reference media that contain exactly defined free concentrations of the target ions. Despite the central importance of proper metal ion buffering, there is still a lack of international standards and beginners in the field may have difficulties finding a coherent description of how to prepare trace metal ion buffers, especially when experiments are to be performed in multi-metal systems...
October 24, 2017: Acta Physiologica
P B Persson
No abstract text is available yet for this article.
October 21, 2017: Acta Physiologica
Hong K Fan, Tian X Luo, Wei D Zhao, Yong H Mu, Yang Yang, Wen J Guo, Hui Y Tu, Qian Zhang
AIM: Junctophilins (JPs), a protein family of the junctional membrane complex, maintain the close conjunction between cell surface and intracellular membranes in striate muscle cells mediating the cross talk between extracellular Ca(2+) entry and intracellular Ca(2+) release. The small conductance Ca(2+) -activated K(+) channels are activated by the intracellular calcium and play an essential role in the cardiac action potential profile. Molecular mechanisms of regulation of the SK channels are still uncertain...
October 21, 2017: Acta Physiologica
Maryam Mostajeran, Friedrich Wetterling, Frank W Blixt, Lars Edvinsson, Saema Ansar
AIM: The aim was to evaluate the beneficial effect of early mitogen activated protein kinase (MEK)1/2 inhibition administered at a clinical relevant time-point using the transient middle cerebral artery occlusion model and a dedicated rodent magnetic resonance imaging system (9.4T) to monitor cerebrovascular changes non-invasively for two weeks. METHOD: Transient middle cerebral artery occlusion was induced in male rats for two hours followed by reperfusion. The specific MEK1/2 inhibitor U0126 was administered i...
October 21, 2017: Acta Physiologica
P B Persson, Anja Bondke Persson
Let us assume that scientists, being on average smart individuals, come with an intrinsic drive to, constantly and based on analytical results, improve the quality of their work and their professional environment. So how can we make science in general and physiological research in particular, better? Answering that question is more than a hypothetical pastime from some ivory tower. This article is protected by copyright. All rights reserved.
October 21, 2017: Acta Physiologica
P B Persson
ICMJE is a non-profit working group of biomedical journal editors. In their annual meetings, ICMJE members work on and update the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE guidelines). In 1978, the first edition was published as Uniform Requirements for Manuscripts Submitted to Biomedical Journals (URMs). This article is protected by copyright. All rights reserved.
October 20, 2017: Acta Physiologica
James Sm Cuffe, Jessica F Briffa, Shannyn Rosser, Andrew L Siebel, Tania Romano, Deanne H Hryciw, Mary E Wlodek, Karen M Moritz
AIM: Uteroplacental insufficiency in rats reduces nephron endowment, leptin concentrations and programs cardiorenal disease in offspring. Cross-fostering growth restricted (Restricted) offspring onto a mother with normal lactation restores leptin concentrations and nephron endowment. This study aimed to determine if the reduced nephron endowment in Restricted offspring is due to delayed glomerular formation and dysregulation of renal genes regulating branching morphogenesis, apoptosis or leptin signalling...
October 19, 2017: Acta Physiologica
Henri A J Puttonen, Maria Sundvik, Svetlana Semenova, Yukako Shirai, Yu-Chia Chen, Pertti Panula
AIM: Histamine receptor H3 has substantial neuropharmacological potential. Currently, knock-out models of this receptor have been investigated only in mice. We characterized the expression of this receptor in the zebrafish and generated a zebrafish histamine receptor H3 knock-out line. Using this model, we studied the role of histamine receptor H3 in important behaviours. We also analyzed the effect of histamine receptor H3 knock-out on monoaminergic systems, which has not been thoroughly studied in any animal model...
October 16, 2017: Acta Physiologica
Heba Salah, Wen Fury, Jesper Gromada, Yu Bai, Tamar Tchkonia, James L Kirkland, Lars Larsson
AIM: Muscle wasting is one of the factors most strongly predicting mortality and morbidity in critically ill intensive care unit (ICU). This muscle wasting affects both limb and respiratory muscles but the understanding of underlying mechanisms and muscle-specific differences remains incomplete. This study aims at investigating the temporal expression and phosphorylation of the Janus kinase / signal transducer and activator of transcription (JAK/STAT) pathway in muscle wasting associated with the ICU condition in order to characterize the JAK/STAT proteins and the related changes leading or responding to their activation during exposure to the ICU condition...
October 15, 2017: Acta Physiologica
Anna Taboni, Nazzareno Fagoni, Giovanni Vinetti, Guido Ferretti
The baroreflex system is a complex mechanism for short-term regulation of arterial blood pressure, involving the heart rate (HR), the heart contractility and the vascular tone in its efferent branches. The study of arterial baroreflexes relies on two different experimental approaches. On one hand, the closed-loop approach analyses the mutual relationship between HR and arterial blood pressure, both in steady state and in dynamic conditions. This article is protected by copyright. All rights reserved.
October 11, 2017: Acta Physiologica
J O Machuki, H Y Zhang, S E Harding, H Sun
Oestrogen receptors (ERs) and β-adrenergic receptors (βARs) play important roles in the cardiovascular system. Moreover, these receptors are expressed in cardiac myocytes and vascular tissues. Numerous experimental observations support the hypothesis that similarities and interactions exist between the signalling pathways of ERs (ERα, ERβ and GPR30) and βARs (β1 AR, β2 AR and β3 AR). The recently discovered oestrogen receptor GPR30 shares structural features with the βARs, and this forms the basis for the interactions and functional overlap...
October 9, 2017: Acta Physiologica
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