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Acta Physiologica

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https://www.readbyqxmd.com/read/28640982/mechanisms-of-sphingosine-1-phosphate-mediated-vasoconstriction-of-rat-afferent-arterioles
#1
Zhengrong Guan, Fuchenchu Wang, Xiangqin Cui, Edward W Inscho
AIM: Sphingosine-1-phosphate (S1P) influences resistance vessel function and is implicated in renal pathological processes. Previous studies revealed that S1P evoked potent vasoconstriction of the preglomerular microvasculature, but the underlying mechanisms remain incompletely defined. We postulated that S1P-mediated preglomerular microvascular vasoconstriction involves activation of voltage-dependent L-type calcium channels (L-VDCC) and the rho/rho kinase pathway. METHODS: Afferent arteriolar reactivity was assessed in vitro using the blood-perfused rat juxtamedullary nephron preparation and diameter was measured during exposure to physiological and pharmacological agents...
June 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28640969/control-of-breathing-and-ventilatory-acclimatization-to-hypoxia-in-deer-mice-native-to-high-altitudes
#2
Catherine M Ivy, Graham R Scott
AIM: We compared the control of breathing and heart rate by hypoxia between high- and low-altitude populations of Peromyscus mice, to help elucidate the physiological specializations that help high-altitude natives cope with O2 limitation. METHODS: Deer mice (P. maniculatus) native to high altitude and congeneric mice native to low altitude (P. leucopus) were bred in captivity at sea level. The F1 progeny of each population were raised to adulthood and then acclimated to normoxia or hypobaric hypoxia (12 kPa, simulating hypoxia at ~4300 m) for 5 months...
June 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28640967/acta-physiologica-award-outperforming-original-articles-from-2015-2017
#3
EDITORIAL
P B Persson
Recently we announced what maybe the highest award in scientific publishing, the Acta Physiologica Award. The Scandinavian Physiological Society, as the owner of Acta Physiologica, sponsors the prize in recognition of your efforts that have increased the journal's performance. Here is an update of some outstanding original articles from 2015 and 2017. This article is protected by copyright. All rights reserved.
June 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636802/2016-impact-factor-for-acta-physiologica-is-4-9
#4
EDITORIAL
P B Persson
How should we best measure journal quality? This never-ending-question remains to be resolved, yet the impact factor receives by far most attention.(1) Suggestions for better metrics (e.g. altmetrics(2) or the Eigenfactor(3) ) soon outnumbers the long list of impact factor flaws This article is protected by copyright. All rights reserved.
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636786/exacta-the-complement-system-in-kidney-diseases
#5
S Reuter, R Mrowka
The complement system, a plasma component, was described upon its discovery to augment the opsonisation of bacteria by antibodies, 'complementing' said antibodies' antibacterial activity. In its first and foremost role, the complement cascade helps convert pathogen recognition into an effective host defence. Two recent publications in Acta Physiologica have highlighted the role of complement factors in immune cell function, namely monoamine transmitter release from immune cells during immune response and inflammation(1, 2) This article is protected by copyright...
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28621031/article-submission-is-the-true-obstacle-of-publishing
#6
EDITORIAL
P B Persson
Tempers flare as the chairman seeks rapid publication to meet grant deadlines, the assistant professor lacking tenure aims for the highest impact factor, whereas the postdoc is sick and tired of ever more rebuttals, and simply wants to end the seemingly endless rejection-resubmission-cycle. This article is protected by copyright. All rights reserved.
June 16, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28613434/cardiac-heterogeneity-and-drug-provoked-arrhythmias
#7
EDITORIAL
Ursula Ravens, Christian Aalkjaer
Functioning of the heart as a mechanical pump depends on electrical impulse formation in the sinus node, conduction of the excitatory wave along its preformed pathways, and orderly repolarisation. This article is protected by copyright. All rights reserved.
June 14, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28613412/myoendothelial-coupling-through-cx40-contributes-to-edh-induced-vasodilation-in-murine-renal-arteries-evidence-from-experiments-and-modelling
#8
Jens Christian Brasen, Cor de Wit, Charlotte Mehlin Sorensen
Regulation of renal vascular resistance plays a major role in controlling arterial blood pressure. The endothelium participates in this regulation as endothelial derived hyperpolarization plays a significant role in smaller renal arteries and arterioles but the exact mechanisms are still unknown AIM: to investigate the role of vascular gap junctions and potassium channels in the renal endothelial derived hyperpolarization. METHODS: in interlobar arteries from wild-type and connexin40 knock-out mice we assessed the role of calcium activated small (SK) and intermediate (IK) conductance potassium channels...
June 14, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28581154/hypoxia-inducible-factor-1-in-myocardial-ischemia-reperfusion-injury
#9
EDITORIAL
Francesco Bellanti
In this issue of Acta Physiologica, Xie et al.(1) describe the protective role of hypoxia-inducible factor-1 (HIF-1) against myocardial ischemia/reperfusion injury in diabetic rats. This study demonstrates that HIF-1 signalling pathway is impaired in diabetes, abolishing the cardioprotective effect of sevoflurane post-conditioning; the administration of deferoxamine re-activates HIF-1 conferring cardioprotection. This article is protected by copyright. All rights reserved.
June 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28580772/exercise-training-increases-skeletal-muscle-mitochondrial-volume-density-by-enlargement-of-existing-mitochondria-and-not-de-novo-biogenesis
#10
Anne-Kristine Meinild Lundby, Robert A Jacobs, Saskia Gehrig, Jeroen de Leur, Moritz Hauser, Thomas C Bonne, Daniela Flück, Sune Dandanell, Niels Kirk, Andreas Kaech, Urs Ziegler, Steen Larsen, Carsten Lundby
AIMS: 1) determine whether exercise induced increases in muscle mitochondrial volume density (MitoVD ) is related to enlargement of existing mitochondria or de novo biogenesis, 2) establish if measures of mitochondrial-specific enzymatic activities are valid biomarkers for exercise induced increases in MitoVD . METHOD: Skeletal muscle samples were collected from twenty-one healthy males prior to and following 6 weeks of endurance training. Transmission electron microscopy was used for estimation of mitochondrial densities and profiles...
June 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28580611/isolated-pulmonary-regurgitation-causes-decreased-right-ventricular-longitudinal-function-and-compensatory-increased-septal%C3%A2-pumping-in-a-porcine-model
#11
Sascha Kopic, Sigurdur S Stephensen, Einar Heiberg, Håkan Arheden, Philipp Bonhoeffer, Mads Ersbøll, Niels Vejlstrup, Lars Søndergaard, Marcus Carlsson
AIM: Longitudinal ventricular contraction is a parameter of cardiac performance with predictive power. Right ventricular longitudinal function is impaired in patients with free pulmonary regurgitation (PR) following corrective surgery for Tetralogy of Fallot (TOF). It remains unclear whether this is a consequence of the surgical repair, or whether it is inherent to PR. The aim of this study was to assess the relationship between longitudinal, lateral and septal pumping in a porcine model of isolated PR...
June 5, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28557294/a-mechanism-for-nav-1-5-downregulation-and-sodium-current-decrease-in-heart-failure
#12
EDITORIAL
Sara Pagans, Marcel Vergés
The pore-forming α-subunit of the cardiac voltage-gated sodium channel, NaV 1.5, is responsible for the initial upstroke of the cardiac action potential. NaV 1.5 cell surface expression and function are modulated by its interaction with regulatory proteins and by posttranslational modifications, such as phosphorylation, arginine methylation or ubiquitination (1) . Genetic mutations in the SCN5A gene, which encodes NaV 1.5, have been associated with a variety of inherited cardiac arrhythmias, including long QT syndrome type 3, Brugada syndrome, atrial fibrillation, and congenital sick sinus syndrome...
May 30, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28548286/obesity-gets-on-your-renal-nerves
#13
EDITORIAL
B L Jensen
No abstract text is available yet for this article.
May 26, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28544543/acute-toll-like-receptor-4-activation-impairs-rat-renal-microvascular-autoregulatory-behaviour
#14
Justin P Van Beusecum, Shali Zhang, Anthony K Cook, Edward W Inscho
AIM: Little is known about how toll-like receptor 4 (TLR4) influences the renal microvasculature. We hypothesized that acute TLR4 stimulation with lipopolysaccharide (LPS) impairs afferent arteriole autoregulatory behaviour, partially through reactive oxygen species (ROS). METHODS: We assessed afferent arteriole autoregulatory behaviour after LPS treatment (1 mg kg(-1) ; i.p.) using the in vitro blood perfused juxtamedullary nephron preparation. Autoregulatory behaviour was assessed by measuring diameter responses to step-wise changes in renal perfusion pressure...
May 25, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28544643/adaptations-to-endurance-training-depend-on-exercise-induced-oxidative-stress-exploiting-redox-inter-individual-variability
#15
Nikos V Margaritelis, Anastasios A Theodorou, Vassilis Paschalis, Aristidis S Veskoukis, Konstantina Dipla, Andreas Zafeiridis, George Panayiotou, Ioannis S Vrabas, Antonios Kyparos, Michalis G Nikolaidis
AIM: The aim of the present study was to reveal the role of reactive oxygen and nitrogen species (RONS) in exercise adaptations under physiological in vivo conditions and without the interference from other exogenous redox agents (e.g., a pro-oxidant or antioxidant). METHODS: We invented a novel methodological set-up that exploited the large redox inter-individual variability in exercise responses. More specifically, we used exercise-induced oxidative stress as the "classifier" measure (i...
May 24, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28544355/temporal-overexpression-of-sirt1-in-skeletal-muscle-of-adult-mice-does-not-improve-insulin-sensitivity-or-markers-of-mitochondrial-biogenesis
#16
Kristoffer Svensson, Samuel A LaBarge, Vitor F Martins, Simon Schenk
AIMS: Activation of the NAD(+) dependent protein deacetylase SIRT1 has been proposed as a therapeutic strategy to treat mitochondrial dysfunction and insulin resistance in skeletal muscle. However, life-long overexpression of SIRT1 in skeletal muscle does not improve parameters of mitochondrial function and insulin sensitivity. In this study we investigated whether temporal overexpression of SIRT1 in muscle of adult mice would affect skeletal muscle mitochondrial function and insulin sensitivity...
May 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28514017/isopimaric-acid-a-multi-targeting-ion-channel-modulator-reducing-excitability-and-arrhythmicity-in-a-spontaneously-beating-mouse-atrial-cell-line
#17
Sajjad Salari, Malin Silverå Ejneby, Johan Brask, Fredrik Elinder
AIM: Atrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well controlled by present drugs. Because some resin acids open voltage-gated potassium channels and reduce neuronal excitability, we explored the effects of the resin acid isopimaric acid (IPA) on action potentials and ion currents in cardiomyocytes. METHODS: Spontaneously beating mouse atrial HL-1 cells were investigated with the whole-cell patch-clamp technique. RESULTS: 1-25 μmol L(-1) IPA reduced the action potential frequency by up to 50%...
May 17, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28513999/microparticles-of-healthy-origins-improve-endothelial-progenitor-cell-dysfunction-via-microrna-transfer-in-an-atherosclerotic-hamster-model
#18
Nicoleta Alexandru, Eugen Andrei, Loredan Niculescu, Emanuel Dragan, Violeta Ristoiu, Adriana Georgescu
AIM: In this study we aimed: (1) to obtain and functionally characterize the cultures of late endothelial progenitor cells (EPCs) from the animal blood; (2) to investigate the potential beneficial effects of circulating microparticles (MPs) of healthy origins on EPC dysfunctionality in atherosclerosis as well as involved mechanisms. METHODS: Late EPCs were obtained and expanded in culture from peripheral blood isolated from two animal groups: hypertensive-hyperlipidemic (HH) and control (C) hamsters...
May 17, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28498559/altitude-sickness-and-altitude-adaptation
#19
EDITORIAL
Pontus B Persson, Anja B Persson
For as long as humanity can recall, it has probably been a dream of mankind to conquer mountainous heights and the mysterious deep. Loss of innocence is a common theme across ancient religions. Ancient Hindu legend has an interesting variation on the story: When Brahma realized that man did not deserve divinity, he decided to take it from them and hide it, but where? Brahma did what researchers up to present day are familiar with: ask your peers, in his case, a board of other gods. Brainstorming yielded a number of potential hiding places...
May 12, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28493603/age-related-endothelial-dysfunction-in-human-skeletal-muscle-feed-arteries-the-role-of-free-radicals-derived-from-mitochondria-in-the-vasculature
#20
Song-Young Park, Oh Sung Kwon, Robert H I Andtbacka, John R Hyngstrom, Van Reese, Michael P Murphy, Russell S Richardson
AIM: This study sought to determine the role of free radicals derived from mitochondria in the vasculature in the recognized age-related endothelial dysfunction of human skeletal muscle feed arteries (SMFAs). METHODS: A total of 44 SMFAs were studied with and without acute exposure to the mitochondria-targeted antioxidant MitoQ and nitric oxide synthase (NOS) blockade. The relative abundance of proteins from the electron transport chain, phosphorylated (p-) to endothelial (e) NOS ratio, manganese superoxide dismutase (MnSOD), and the mitochondria-derived superoxide (O2(-) ) levels were assessed in SMFA...
May 11, 2017: Acta Physiologica
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