journal
MENU ▼
Read by QxMD icon Read
search

Acta Physiologica

journal
https://www.readbyqxmd.com/read/28231640/mind-the-gap-mechanisms-regulating-the-endothelial-barrier
#1
REVIEW
Mariya Y Radeva, Jens Waschke
The endothelial barrier consists of intercellular contacts localized in the cleft between endothelial cells, which is covered by the glycocalyx in a sieve-like manner. Both types of barrier-forming junctions, i.e. the adherens junction (AJ) serving mechanical anchorage and mechanotransduction and the tight junction (TJ) sealing the intercellular space to limit paracelullar permeability, are tethered to the actin cytoskeleton. Under resting conditions, the endothelium thereby builds a selective layer controlling the exchange of fluid and solutes with the surrounding tissue...
February 23, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28218996/hypoxia-stimulated-membrane-trafficking-requires-t-plastin
#2
Marieke Wottawa, Stephanie Naas, Johannes Böttger, Gijsbert J van Belle, Wiebke Möbius, Natalia H Revelo, Doris Heidenreich, Melanie von Ahlen, Anke Zieseniss, Katharina Kröhnert, Susanne Lutz, Christof Lenz, Henning Urlaub, Silvio O Rizzoli, Dörthe M Katschinski
Traffic between the plasma membrane and the endomembrane compartments is an essential feature of eukaryotic cells. The secretory pathway sends cargoes from biosynthetic compartments to the plasma membrane. This is counterbalanced by a retrograde endocytotic route and is essential for cell homeostasis. Cells need to adapt rapidly to environmental challenges like the reduction of pO2 which, however, has not been analyzed in relation to membrane trafficking in detail. Therefore we determined changes in the plasma membrane trafficking in normoxia, hypoxia, and after reoxygenation METHODS: Membrane trafficking was analyzed by using the bulk membrane endocytosis marker FM 1-43, the newly developed membrane probe mCLING, wheat germ agglutinin as well as fluorescently labeled choleratoxin subunit B...
February 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28207997/chronically-elevated-bilirubin-protects-from-cardiac-reperfusion-injury-in-the-male-gunn-rat
#3
Bhavisha Bakrania, Eugene F Du Toit, Kevin J Ashton, Karl-Heinz Wagner, John P Headrick, Andrew C Bulmer
AIMS: Bilirubin is associated with reduced risk of cardiovascular disease, as evidenced in conditions of mild hyperbilirubinaemia (Gilbert's Syndrome). Little is known regarding myocardial stress-resistance in hyperbilirubinemic conditions or whether life-long exposure modifies cardiac function, which might contribute to protection from cardiovascular disease. METHODS: Hyperbilirubinemic rats and littermate controls underwent echocardiography at 3, 6 and 12 mo of age, with hearts subsequently assessed for resistance to 30 min of ischaemia...
February 16, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28199786/alpha-adrenergic-receptor-blockade-increases-capillarisation-and-fractional-o2-extraction-and-lowers-blood-flow-in-contracting-human-skeletal-muscle
#4
Stefan P Mortensen, Stuart Egginton, Mads Madsen, Jonas B Hansen, Gregers D W Munch, Ulrik Winning Iepsen, Thorbjörn Åkerström, Bente K Pedersen, Ylva Hellsten
AIM: To investigate the effect of elevated basal shear stress on angiogenesis in humans, and the role of enhanced skeletal muscle capillarisation on blood flow and O2 extraction. METHODS: Limb haemodynamics and O2 extraction was measured at rest and during one-leg knee-extensor exercise (12 and 24W) in 10 healthy untrained young men before and after 4 weeks treatment with an α1 receptor-antagonist (Terazosin, 1-2 mg day(-1) ). Corresponding biopsies were taken from the m...
February 15, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28181735/the-innervation-of-the-kidney-in-renal-injury-and-inflammation-a-cause-and-consequence-of-deranged-cardiovascular-control
#5
REVIEW
Mohammed H Abdulla, Edward J Johns
Extensive investigations have revealed that renal sympathetic nerves regulate renin secretion, tubular fluid reabsorption and renal haemodynamics which can impact on cardiovascular homoeostasis normally and in pathophysiological states. The significance of the renal afferent innervation and its role in determining the autonomic control of the cardiovascular system is uncertain. The transduction pathways at the renal afferent nerves have been shown to require pro-inflammatory mediators and TRPV1 channels. Reno-renal reflexes have been described, both inhibitory and excitatory, demonstrating that a neural link exists between kidneys and may determine the distribution of excretory and haemodynamic function between the two kidneys...
February 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28173614/arterial-hypertension
#6
EDITORIAL
R Mrowka
Blood pressure is an important determinant in the progression of many cardiovascular and renal diseases. The interest of the physiologists in this topic is reflected in the high number of articles that appeared in Acta Physiologica recently. About 20% of the articles in Acta Physiologica contain the keyword blood pressure or hypertension in the year 2016. According to the semantic analysis website gopubmed. org the term pressure is top rating among all semantic "concepts" in Acta Physiologica if one looks at the years 2014-2016...
February 7, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28129470/the-water-channel-aqp1-is-expressed-in-human-atherosclerotic-vascular-lesions-and-aqp1-deficiency-augments-angiotensin-ii-induced-atherosclerosis-in-mice
#7
Pamela Wintmo, Søren H Johansen, Pernille B L Hansen, Jes S Lindholt, Sigitas Urbonavicius, Lars M Rasmussen, Peter Bie, Boye L Jensen, Jane Stubbe
AIM: The water channel aquaporin 1 (AQP1) promotes endothelial cell migration. It was hypothesized that AQP1 promotes neovascularization and growth of atherosclerotic plaques. METHODS: AQP1 immunoreactivity and protein abundance was examined in human and murine atherosclerotic lesions and aortic aneurysms. Apolipoprotein E (ApoE) knockout (-/-) and AQP1-/-ApoE-/- were developed and fed western diet (WD) for 8 and 16 weeks to accelerate the atherosclerosis process...
January 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28112877/autophagy-in-renal-tubular-injury-and-repair
#8
REVIEW
Fangming Lin
Autophagy is a fundamental cellular process that maintains normal function and structure of the cell. It can be induced during stress and serves as an adaptive response for cell survival. Normal kidneys have high metabolic demands yet are relatively hypoxic, especially in the medulla and papilla. Injury or aging aggravates metabolic perturbation and activates autophagy in many types of renal cells. In the kidney, tubular epithelial cells consume the most energy due to active transport mechanisms and therefore are the most susceptible to injuries from hypoxic or low energy states...
January 23, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28103427/repeated-maximal-intensity-hypoxic-exercise-superimposed-to-hypoxic-residence-boosts-skeletal-muscle-transcriptional-responses-in-elite-team-sport-athletes
#9
Franck Brocherie, Grégoire P Millet, Gommaar D'Hulst, Ruud Van Thienen, Louise Deldicque, Olivier Girard
AIM: To determine whether repeated maximal-intensity hypoxic exercise induces larger beneficial adaptations on the hypoxia inducible factor-1α pathway and its target genes than similar normoxic exercise, when combined with chronic hypoxic exposure. METHODS: Lowland elite male team-sport athletes underwent 14 days of passive normobaric hypoxic exposure (≥14 h.day(-1) at Fi O2 14.5-14.2%) with the addition of six maximal-intensity exercise sessions either in normobaric hypoxia (Fi O2 ~14...
January 19, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28035739/targeting-mitogen-activated-protein-kinase-in-acute-ischemic-stroke
#10
EDITORIAL
Qiang Liu, Rayna J Gonzales
Despite the substantial progress that has been made over the past decades, there remains a dearth of approaches for the effective management of acute stroke. To date, many attempts for brain protection fail in clinical trials, presenting an unmet need for identification of new treatment options. This article is protected by copyright. All rights reserved.
December 30, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/28029731/reduced-blood-glucose-through-thyroid-hormone-degradation-product
#11
EDITORIAL
Lena Eliasson
Western lifestyle with increasing obesity together with genetic factors contribute to the rising prevalence of type 2 diabetes in the population. In practice the hyperglycaemia is due to insulin resistance and failure of the insulin secreting beta cells to adjust to the increased metabolic demand (Halban et al., 2014). Improvements in lifestyle with increased exercise and reduced energy consumption would be beneficial for human health (Hagberg et al., 2012). A more personalized regime has also been suggested due to the heterogeneity of the disease why new individual treatments needs to be discovered...
December 28, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/28024118/maternal-fetal-cholesterol-transport-in-the-second-half-of-mouse-pregnancy-does-not-involve-lrp2
#12
Mathijs V Zwier, Maria E Baardman, Theo H van Dijk, Angelika Jurdzinski, Lambertus J Wisse, Vincent W Bloks, Rolf M F Berger, Marco C DeRuiter, Albert K Groen, Torsten Plösch
AIM: Lipoprotein related receptor protein type 2 (LRP2) is highly expressed on both yolk sac and placenta. Mutations in the corresponding gene are associated with severe birth defects in humans, known as Donnai-Barrow syndrome. We here characterized the contribution of LRP2 and maternal plasma cholesterol availability to maternal-fetal cholesterol transport and fetal cholesterol levels in utero in mice. METHODS: Lrp2(+/-) mice were mated heterozygously to yield fetuses of all 3 genotypes...
December 26, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/28024113/a-novel-and-complex-mechanism-regulating-pgc-1%C3%AE-4-expression
#13
EDITORIAL
Bradley S Gordon
In the current issue of Acta Physiologica, Brown et al. (Brown et al. 2016) describes a novel regulatory mechanism for the expression of the Peroxisome Proliferator Activated Receptor Gamma Co-activator 1 alpha (PGC-1α) splice variant 4 (PGC-1α4). Since the discovery of the parent PGC-1α gene, it has been at the forefront of muscle biology research as it significantly altered muscle phenotype in both pathological and physiological model systems (Lin et al. 2002, Sandri et al. 2006). This article is protected by copyright...
December 26, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27981782/neuromuscular-changes-and-the-rapid-adaptation-following-a-bout-of-damaging-eccentric-exercise
#14
S Goodall, K Thomas, M Barwood, K Keane, J T Gonzalez, A St Clair Gibson, G Howatson
INTRODUCTION: An initial bout of eccentric exercise is known to protect against muscle damage following a repeated bout of the same exercise; however, the neuromuscular adaptations owing to this phenomenon are unknown. AIM: To determine whether neuromuscular disturbances are modulated following a repeated bout of eccentric exercise. METHODS: Following eccentric exercise performed with the elbow flexors, we measured maximal voluntary force, resting twitch force, muscle soreness, creatine kinase (CK) and voluntary activation (VA) using motor point and motor cortex stimulation at baseline, immediately post-exercise and at 1, 2, 3, 4 and 7 days post-exercise on two occasions, separated by 3 weeks...
December 16, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27981759/writing-brilliant-manuscripts
#15
EDITORIAL
P B Persson
No abstract text is available yet for this article.
December 16, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27981752/the-effect-of-physical-fatigue-on-oscillatory-dynamics-of-the-sensorimotor-cortex
#16
A Fry, K J Mullinger, G C O'Neill, M J Brookes, J P Folland
AIM: While physical fatigue is known to arise in part from supraspinal mechanisms within the brain, exactly how brain activity is modulated during fatigue is not well understood. Therefore, this study examined how typical neural oscillatory responses to voluntary muscle contractions were affected by fatigue. METHODS: Eleven healthy adults (age 27 ± 4 years) completed two experimental sessions in a randomized crossover design. Both sessions first assessed baseline maximal voluntary isometric wrist-flexion force (MVFb )...
December 16, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27896930/you-are-not-alone
#17
EDITORIAL
M Ludwig, A Högner, A Patzak
No abstract text is available yet for this article.
November 29, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/28103422/vitamin-supplementation
#18
EDITORIAL
P B Persson, A B Persson
No abstract text is available yet for this article.
March 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28028935/renoprotection-focus-on-trpv1-trpv4-trpc6-and-trpm2
#19
REVIEW
L Markó, M Mannaa, T N Haschler, S Krämer, M Gollasch
Members of the transient receptor potential (TRP) cation channel receptor family have unique sites of regulatory function in the kidney which enables them to promote regional vasodilatation and controlled Ca(2+) influx into podocytes and tubular cells. Activated TRP vanilloid 1 receptor channels (TRPV1) have been found to elicit renoprotection in rodent models of acute kidney injury following ischaemia/reperfusion. Transient receptor potential cation channel, subfamily C, member 6 (TRPC6) in podocytes is involved in chronic proteinuric kidney disease, particularly in focal segmental glomerulosclerosis (FSGS)...
March 2017: Acta Physiologica
https://www.readbyqxmd.com/read/27690155/cyclosporin-a-induces-renal-episodic-hypoxia
#20
M Fähling, S Mathia, J Scheidl, R Abramovitch, Z Milman, A Paliege, H Peters, P B Persson, S N Heyman, C Rosenberger
AIM: Cyclosporin A (CsA) causes renal toxicity. The underlying mechanisms are incompletely understood, but may involve renal hypoxia and hypoxia-inducible factors (Hifs). We sought for hypoxia and Hif in mouse kidneys with CsA-induced toxicity, assessed their time course, Hif-mediated responses and the impact of interventional Hif upregulation. METHODS: Mice received CsA or its solvent cremophore for up to 6 weeks. Low salt diet (Na(+) ↓) was given in combination with CsA to enhance toxicity...
March 2017: Acta Physiologica
journal
journal
41230
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"