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Journal of Physiological Sciences: JPS

Paul D Loprinzi, Emily Frith
The objective of this paper was to systematically evaluate the potential preventive and therapeutic effects of exercise in attenuating stress-induced memory impairment. A systematic review was employed, searching PubMed, PsychInfo, Sports Discus and Google Scholar databases. For eligibility, studies had to be published in English, employ an experimental design, have the acute or chronic bout of exercise occur prior to, during or after the stressor, implement a psychophysiological stressor, and have an assessment of memory function occurring after the stressor...
September 10, 2018: Journal of Physiological Sciences: JPS
Sae Uchida, Hiroshi Taniguchi, Yoshie Ito, Fusako Kagitani
We aimed to determine whether acupuncture to the auricular region increases cortical regional cerebral blood flow (rCBF). The rCBF was measured using laser speckle contrast imaging in urethane-anesthetized rats. Acupuncture stimulation was performed manually at the auricular concha or abdomen. The former's stimulation significantly increased the rCBF of the bilateral cerebral cortex in the frontal, parietal, and occipital lobes without altering the systemic arterial pressure. In contrast, abdominal stimulation affected neither rCBF nor systemic arterial pressure...
September 6, 2018: Journal of Physiological Sciences: JPS
Toru Kawada, Shuji Shimizu, Kazunori Uemura, Yohsuke Hayama, Hiromi Yamamoto, Toshiaki Shishido, Takuya Nishikawa, Masaru Sugimachi
Ivabradine is a selective bradycardic agent that inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. HCN channels play a key role in mediating the positive chronotropic response to sympathetic nerve stimulation (SNS). We examined whether ivabradine would interfere with dynamic sympathetic control of heart rate (HR). The effect of intravenous ivabradine (2 mg/kg, n = 7) or metoprolol (10 mg/kg, n = 6) on the transfer function from SNS to HR was examined in anesthetized rats...
September 6, 2018: Journal of Physiological Sciences: JPS
Reiko Terashima, Maki Kimura, Asuka Higashikawa, Yuki Kojima, Tatsuya Ichinohe, Masakazu Tazaki, Yoshiyuki Shibukawa
Bradykinin (BK) and its receptors, B1 and B2 , in trigeminal ganglion (TG) neurons are involved in the regulation of pain. Recent studies have revealed that B1 receptors are expressed in neonatal rat TG neurons; however, the intracellular signaling pathway following B1 receptor activation remains to be elucidated. To investigate the mechanism by which B1 receptor activation leads to intracellular Ca2+ mobilization, we measured the intracellular free Ca2+ concentration ([Ca2+ ]i ) in primary-cultured TG neurons...
September 4, 2018: Journal of Physiological Sciences: JPS
Hirofumi Tanaka
Arterial stiffness increases with advancing age and is an important risk factor for cardiovascular disease. As the number of research studies investigating arterial stiffness has increased dramatically over the recent years, their scope has broadened from physiological investigations to clinical domains focused on risk predictions. A number of key research studies were conducted in Japan in the formative years; however, some of these studies are unknown to most and largely forgotten. In this mini-review, some of these key formative research studies conducted in Japan by Japanese investigators are re-introduced and highlighted to provide appreciation for their pioneering work conducted in the land of the rising sun...
August 28, 2018: Journal of Physiological Sciences: JPS
Jian Cao, Runjie Wei, Shukun Yao
Mitochondrial homeostasis is closely associated with liver cancer progression via multiple mechanisms and is also a potential tumour-suppressive target in clinical practice. However, the role of mitochondrial fission in liver cancer cell viability has not been adequately investigated. Matrine, a type of alkaloid isolated from Sophora flavescens, has been widely used to treat various types of cancer. However, the molecular effect of matrine on mitochondrial homeostasis is unclear. Therefore, the aim of the current study was to determine the role of mitochondrial fission in cell apoptosis, viability, migration and proliferation of HepG2 cells in vitro...
August 28, 2018: Journal of Physiological Sciences: JPS
(no author information available yet)
In the original publication of the article, there are following misprints in the numbering of the planned symposia.
August 24, 2018: Journal of Physiological Sciences: JPS
Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa
Vascular smooth muscle cell (VSMC) migration and the subsequent intimal thickening play roles in vascular restenosis. We previously reported that an exchange protein activated by cAMP 1 (Epac1) promotes platelet-derived growth factor (PDGF)-induced VSMC migration and intimal thickening. Because basic fibroblast growth factor (bFGF) also plays a pivotal role in restenosis, we examined whether Epac1 was involved in bFGF-mediated VSMC migration. bFGF-induced lamellipodia formation and migration were significantly decreased in VSMCs obtained from Epac1-/- mice compared to those in Epac1+/+ -VSMCs...
August 6, 2018: Journal of Physiological Sciences: JPS
Kouichi Shiozawa, Yasumasa Mototani, Kenji Suita, Aiko Ito, Naoya Kawamura, Yuka Yagisawa, Ichiro Matsuo, Yoshio Hayakawa, Megumi Nariyama, Daisuke Umeki, Yasutake Saeki, Yoshiki Ohnuki, Satoshi Okumura
Although multiple factors influence food bite size, the relationship between food bite size per mouthful and mandible or tongue size remains poorly understood. Here, we examined the correlations between food bite size and the lower dental arch size (an indicator of tongue size) in human subjects with good oral and general health, using fish sausage and bread as test foods. Notably, bite size of both foods was significantly positively correlated with the lower dental arch size, whereas masticatory performance (measured in terms of glucose extraction from a gummy jelly) showed no dependence on bite size...
July 28, 2018: Journal of Physiological Sciences: JPS
Yuki Uchida, Koyuki Atsumi, Akira Takamata, Keiko Morimoto
Japanese women can experience a sensation of cold feet in daily life. It is possible that this sensation of coldness in feet may be associated with female hormones, but to date the effect of menstrual cycle phase on the skin temperature (Tsk ) of the foot during local cooling is unknown. We therefore examined Tsk and partial cutaneous blood flow in the foot during the follicular (F) and luteal (L) phases of the menstrual cycle in women experiencing local cooling. Tsk was measured in the toes and the dorsum of the left foot using infrared thermography, while cutaneous blood flow was evaluated in the big toe of the left foot using laser Doppler flowmetry (LDF), both at 28 °C...
July 25, 2018: Journal of Physiological Sciences: JPS
Narongrit Thongon, Siriporn Chamniansawat
The mechanism of proton pump inhibitors (PPIs) suppressing intestinal Mg2+ uptake is unknown. The present study aimed to investigate the role of purinergic P2Y receptors in the regulation of Mg2+ absorption in normal and omeprazole-treated intestinal epithelium-like Caco-2 monolayers. Omeprazole suppressed Mg2+ transport across Caco-2 monolayers. An agonist of the P2Y2 receptor, but not the P2Y4 or P2Y6 receptor, suppressed Mg2+ transport across control and omeprazole-treated monolayers. Omeprazole enhanced P2Y2 receptor expression in Caco-2 cells...
July 21, 2018: Journal of Physiological Sciences: JPS
Shigetomo Suyama, Toshihiko Yada
Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other GABAergic neurons act as an orexigenic. Here, we review the progress of studies on hypothalamic GABAergic neurons distributed in ARC, dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH). Three advanced technologies have been applied and greatly contributed to the recent progress...
July 12, 2018: Journal of Physiological Sciences: JPS
Wancheng Yu, Mei Xu, Tao Zhang, Qian Zhang, Chengwei Zou
Cardiac ischemia-reperfusion (I/R) injury results mainly from mitochondrial dysfunction and cardiomyocyte death. Mitophagy sustains mitochondrial function and exerts a pro-survival effect on the reperfused heart tissue. Mammalian STE20-like kinase 1 (Mst1) regulates chronic cardiac metabolic damage and autophagic activity, but its role in acute cardiac I/R injury, especially its effect on mitophagy, is unknown. The aim of this study is to explore whether Mst1 is involved in reperfusion-mediated cardiomyocyte death via modulation of FUN14 domain containing 1 (FUNDC1)-related mitophagy...
June 30, 2018: Journal of Physiological Sciences: JPS
Kanako Wakabayashi-Nakao, Yingchun Yu, Miyuki Nakakuki, Tzyh-Chang Hwang, Hiroshi Ishiguro, Yoshiro Sohma
A massive deletion over three exons 16-17b in the CFTR gene was identified in Japanese CF patients with the highest frequency (about 70% of Japanese CF patients definitely diagnosed). This pathogenic mutation results in a deletion of 153 amino acids from glycine at position 970 (G970) to threonine at 1122 (T1122) in the CFTR protein without a frameshift. We name it Δ(G970-T1122)-CFTR. In the present study, we characterized the Δ(G970-T1122)-CFTR expressed in CHO cells using immunoblots and a super resolution microscopy...
June 27, 2018: Journal of Physiological Sciences: JPS
Maria Guadalupe Soares Amorim, Maurício Dias de Oliveira, Daiane Santos Soares, Leandro da Silva Borges, Alexandre Dermargos, Elaine Hatanaka
The original article was corrected.
September 2018: Journal of Physiological Sciences: JPS
Dong-Joo Hwang, Jung-Hoon Koo, Ki-Cheon Kwon, Dong-Hoon Choi, Sung-Deuk Shin, Jae-Hoon Jeong, Hyun-Seob Um, Joon-Yong Cho
Dysfunction of mitophagy, which is a selective degradation of defective mitochondria for quality control, is known to be implicated in the pathogenesis of Parkinson's disease (PD). However, how treadmill exercise (TE) regulates mitophagy-related molecules in PD remains to be elucidated. Therefore, we aimed to investigate how TE regulates α-synuclein (α-syn)-induced neurotoxicity and mitophagy-related molecules in the nigro-striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mice. Our data showed that TE exhibited a significant restoration of tyrosine hydroxylase and motor coordination with suppression of α-syn expression, hallmarks of PD, possibly via up-regulation of lysosomal degradation molecules, LAMP-2 and cathepsin L, with down-regulation of p62, LC3-II/LC3-I ratio, PINK1 and parkin in the substantia nigra of MPTP mice...
September 2018: Journal of Physiological Sciences: JPS
Marwa Hassan Muhammad, Mona Maher Allam
Mitochondrial dysfunction and decreased mitochondrial content are hallmarks of aging that leads to decreased physical endurance. Our aim was to explore the anti-aging effect of resveratrol (RSVT) supplementation, a polyphenol, and/or exercise training, started at an older age, on improving physical activity, therefore, help in frailty avoidance and promotion of healthy aging in elderly. Eighteen-month-old aged mice received RSVT (15 mg/kg/day) and/or exercise trained for 4 weeks showed significant longer time to exhaustion with decreased blood lactate and free fatty acids levels associated with improved oxidative stress evidenced by decreased gastrocnemius muscle lipid peroxidation and increased antioxidant enzymes activities, catalase and superoxide dismutase, when compared to aged mice control group...
September 2018: Journal of Physiological Sciences: JPS
Daniela Delwing-de Lima, Ariene Sampaio Souza Farias Ulbricht, Carla Werlang-Coelho, Débora Delwing-Dal Magro, Victor Hugo Antonio Joaquim, Eloise Mariani Salamaia, Silvana Rodrigues de Quevedo, Larissa Desordi
We evaluated the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) protocols on the alterations in oxidative stress parameters caused by a high-fat diet (HFD), in the blood and liver of rats. The HFD enhanced thiobarbituric acid reactive substances (TBA-RS) and protein carbonyl content, while reducing total sulfhydryl content and catalase (CAT) and glutathione peroxidase (GSH-Px) activities in the blood. Both training protocols prevented an increase in TBA-RS and protein carbonyl content, and prevented a reduction in CAT...
September 2018: Journal of Physiological Sciences: JPS
Kiyotaka Mukai, Yuhichi Kuda, Toshishige Shibamoto, Mamoru Tanida, Yasutaka Kurata, Hitoshi Yokoyama
We determined the renal responses to anaphylaxis and the effects of a nitric oxide synthesis inhibitor, L-NAME, in anesthetized rats and isolated perfused rat kidneys. After the ovalbumin antigen injection, the sensitized rats showed transient and substantial decreases in mean blood pressure and renal blood flow and an increase in renal vascular resistance. Creatinine clearance, a measure of renal function, decreased to 53% baseline at 2 h after antigen. L-NAME pretreatment significantly enhanced the antigen-induced renal vasoconstriction and renal dysfunction...
September 2018: Journal of Physiological Sciences: JPS
Maria Guadalupe Soares Amorim, Maurício Dias de Oliveira, Daiane Santos Soares, Leandro da Silva Borges, Alexandre Dermargos, Elaine Hatanaka
The aim of this study was to examine the effects of exergaming on the cardiovascular risk factors and adipokine levels of women engaged in the music video game Just Dance using the Xbox 360 Kinect console. Triglycerides, total cholesterol, HDL, LDL, FFA, CRP, TNF-α, Il-1β, IL-6, leptin, and resistin were measured in sedentary women before and 1 month after the practice of exergaming. We also evaluated anthropometric parameters. Our results indicate that total serum cholesterol, triglycerides, and LDL were reduced by 64, 29, and 12%, respectively...
September 2018: Journal of Physiological Sciences: JPS
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