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Current Rheumatology Reviews

Hassan Bassiouni, Ahmed El-Atrebi, Khaled Zaky
BACKGROUND: Amyloidosis is a life threatening complication of Rheumatoid Arthritis (RA) that should be detected as early as possible to avoid its morbidity and mortality. OBJECTIVE: To detect subclinical amyloidosis in RA patients without proteinuria and a disease duration more than 5 years. PATIENTS: Eighty-six RA patients seen between October 2013 and August 2014 were recruited for the study. Those with 5 years disease duration were included in the study but those who had proteinuria, serum creatinine > 1...
September 3, 2018: Current Rheumatology Reviews
Dhruvkumar M Patel, Mukundkumar V Patel, Kamal H Sharma, Greshaben Rajeshkumar Patel, Manish B Patel, Vipul B Shah
BACKGROUND: Atherosclerosis and coronary plaque destabilization are linked to each other. Infections due to various microbes may trigger acute coronary syndrome (ACS) by systemic inflammation cascade. METHODS: We have evaluated the prevalence of Post chikungunya chronic arthritis (PCCA) among 400 consecutive ACS patients (Case group) and compared with control group subjected to elective surgery by the prospective case-control observational study. Cases were excluded if standard criteria of ACS were not satisfied and in control group if the patient suffered a myocardial infarction (MI) within 28 days of elective surgery...
August 15, 2018: Current Rheumatology Reviews
Victoria A Flower, Shaney L Barratt, Stephen Ward, John D Pauling
The pathological hallmarks of Systemic sclerosis (SSc) constitute an inter-related triad of autoimmunity, vasculopathy and tissue remodeling. Many signaling mediators have been implicated in SSc pathology; most focusing on individual components of this pathogenic triad and current treatment paradigms tend to approach management of such as distinct entities. The present review shall examine the role of vascular endothelial growth factor (VEGF) in SSc pathogenesis. We shall outline potential mechanisms whereby differential vascular endothelial growth factor-A (VEGF-A) isoform expression (through conventional and alternative VEGF-A splicing,) may influence the relevant burden of vasculopathy and fibrosis offering novel insight into clinical heterogeneity and disease progression in SSc...
August 9, 2018: Current Rheumatology Reviews
Rehab Ali Ibrahim, Nour El-Hoda Hussien Abdalla, Engy Amr Husssein Shabaan, Noha Bassiouny Hassan Mostafa
BACKGROUND: Scleroderma or systemic sclerosis (SSc) is a rare systemic autoimmune disease. Many conditions mimic the presentation of SSc, especially skin thickening and fibrosis. One of these conditions is scleredema, a rare collagen and mucin deposition disorder which was found to be associated with diabetes mellitus, streptococcal infection or monoclonal gammopathy. CASE PRESENTATION: A 55 years old female presented with insidious onset and progressive course of diffuse skin thickening of face, neck, arms, forearms, thighs, chest, back, and sparing both hands and feet of 6 years duration associated with arthralgia, dysphagia and dyspnea on exertion of 1-year duration...
August 7, 2018: Current Rheumatology Reviews
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Piercarlo Sarzi-Puttini
BACKGROUND: The presence of neuropatic pain (NeP) is common in subjects with established rheumatoid arthritis (RA), and it can influence the disease remission. These aspects have not been investigated in patients with early rheumatoid arthritis (ERA). OBJECTIVE: To investigate the effect of NeP on the achievement of remission in patients with ERA. METHOD: The study involved consecutive patients with moderately or highly active ERA (a score of >11 on the Simplified Disease Activity Index)...
August 6, 2018: Current Rheumatology Reviews
Ivan Posso-Osorio, Juan Naranjo-Escobar, Diana Marcela Loaiza, Marcela Polo, Alex Echeverri, Gabriel J Tobon
BACKGROUND: Sjögren's syndrome is an autoimmune disease characterised by exocrinopathy mainly involving the salivary and lacrimal glands. In addition, it is a multisystemic condition (i.e., affecting multiple organs and systems). Neurological involvement has been reported in ~20% of cases, with peripheral manifestations being the most frequent. METHOD: We analysed four cases in which neurological manifestations were the first symptoms of Sjögren's syndrome. RESULTS: In all four cases, neurological symptoms preceded sicca symptoms...
July 30, 2018: Current Rheumatology Reviews
Selcan Demir, Hafize Emine Sonmez, Seza OZen
In the last decade we have come to better understand and manage the vasculitides. Classification of vasculitides has been revised. Genome- wide association studies and linkage analyses have been undertaken in hope of better understanding the pathogenesis of vasculitides. Comprehensive genetic studies have highlighted new pathways that may guide us in more targeted therapies. Description of the monogenic forms of vasculitis, such as deficiency of adenosine deaminase type 2 (DADA2), haploinsufficiency of A20 (HA20), have introduced a new perspective to vasculopathies, and introduced alternative treatments for these diseases...
July 25, 2018: Current Rheumatology Reviews
Elham Rajaei, Habib Haybar, Karim Mowla, Zeinab Deris Zayeri
BACKGROUND: Rheumatoid arthritis is a widespread autoimmune disease and inflammation and bone destruction are two main issues in rheumatoid arthritis. OBJECTIVE: To discussing metformin effects on rheumatoid arthritis complications. METHOD: We conducted a narrative literature search including clinical trials, experimental studies on laboratory animals and cell lines. Our search covered Medline, PubMed and Google Scholar databases from 1999 until 2018...
July 17, 2018: Current Rheumatology Reviews
Quan-Bo Zhang, Dan Zhu, Zhong Wen, Ting Yi, Qing Li, Yu-Feng Qing, Jing-Guo Zhou
OBJECTIVE: To investigate the changes of serum uric acid (sUA), lipids and cystatin C (CysC) in primary gout patients, and to explore the clinical significance in gout patients. METHODS: sUA, CysC, high-sensitivity C-reactive protein (hsCRP) and other biochemical parameters were measured in 326 gout patient and 210 healthy control subjects, blood cell counts were also detected. Clinical data were collected from gout patients. RESULTS: sUA, CysC, hsCRP, Body Mass Index (BMI), white blood cell (WBC) counts, neutrophil granulocyte (GR), monocyte (Mo), triglycerides (TG), plasma total cholesterol (TC), very low density lipoprotein (VLDL), apolipoprotein B100 (apoB100), blood glucose (GLU), serum creatinine (sCr) and urea nitrogen (BUN) were significantly increased in gout patients compared with HC subjects (P<0...
July 4, 2018: Current Rheumatology Reviews
Asghar Zare, Mohammadali Nazarinia, Mesbah Shams, Mohammad Javad Fallahi
BACKGROUND: Systemic sclerosis (SSc) is a disorder of connective tissue affecting the skin and internal organs, characterized by fibrotic changes of peripheral and visceral architecture. OBJECTIVE: We investigated the correlation between serum concentration of homocysteine and interstitial lung involvement in SSc patients. METHOD: Fifty nine patients with SSc (53 females and 6 males) with a mean age of 43.34 years (range: 17-76 years) were enrolled...
June 28, 2018: Current Rheumatology Reviews
Y V Raghava Neelapala
Knee Osteoarthritis (OA) is a disabling musculoskeletal condition among the elderly. Self-reported instability is one of the impairments associated with osteoarthritis. A complete understanding of the self-reported instability in knee OA is essential, to identify the best strategies for overcoming this impairment. The focus of this scoping review is to provide an overview of evidence supported information about the prevalence and other associated features of self-reported instability in Knee OA. A broad search of the database PubMed with keywords such as knee osteoarthritis and instability resulted in 1075 articles...
June 27, 2018: Current Rheumatology Reviews
Jibran Sualeh Muhammad, Muhammad Ishaq, Khalid Ahmed
Behçet's syndrome (BS) is characterized numerous systemic manifestations, is known for its ability to affect both, arteries and the veins. However, the etiology of BS is only partially understood, and previous studies have demonstrated a role of genetic and epigenetic factors contributes to disease pathophysiology. Several studies have implicated the T cells and monocytes, especially when stimulated by seat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in lymphocyte proliferation, maturation, and differentiation, is activated in Behçet's syndrome...
May 20, 2018: Current Rheumatology Reviews
Percy G Balderia, Nicole Andeen, Jonathan A Jefferson
BACKGROUND: It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called "double-positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone...
May 16, 2018: Current Rheumatology Reviews
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
Jagannath Sharma, R Heagerty, S Dalal, B Banerjee, T Booker
BACKGROUND: Musculoskeletal injury (MSKI), a common problem in both military and physically active civilian populations has been suggested to result from both extrinsic and intrinsic factors. OBJECTIVE: This study was to investigate prospectively whether gait biomechanics, aerobic fitness level and smoking status as well as entry military selection test variables can be used to predict MSKI development during recruit training. METHOD: British infantry male recruits (n = 562) were selected for the study...
April 29, 2018: Current Rheumatology Reviews
Somayeh Shariatmaghani, Roshanak Salari, Maryam Sahebari, Payman Shalchiantabrizi, Masoumeh Salari
Sarcoidosis is a multisystem inflammatory disease with an etiology that is not clearly understood. Amongst the different organs that may be affected, the lungs are the most common. Musculoskeletal manifestations of the disease are uncommon. They include arthropathy, bone lesions, or myopathy, all of which may occur as initial symptoms or develop during the course of the disease. Articular involvement my present as arthralgia or arthritis. Skeletal complications usually develop in the chronic state of the disease...
April 24, 2018: Current Rheumatology Reviews
Mohammadali Nazarinia, Elmira Esmaeilzadeh
INTRODUCTION: Gauzoma is an iatrogenic complication, which occurs rarely due to surgical team negligence. Depending on the sterility of the retained tissue, it can lead to life threatening surgical complications or may remain asymptomatic for many years and be detected incidentally in imaging studies. It may be mistaken as tumors or aneurysms. Thus, high clinical suspicion is needed to diagnose them in patients with past history of operation. Reporting Case: A 35 years old woman, a known case of scleroderma underwent open-heart surgery 20 years before being diagnosed as scleroderma, presented by dyspnea especially on activity...
April 22, 2018: Current Rheumatology Reviews
Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
BACKGROUND: Juvenile scleroderma is a rarely seen chronic connective tissue disorder characterized by stiffening of the skin. The frequency of the disease was reported as one per million. According to organ involvement, the disease is divided into two main forms: systemic and localized scleroderma. OBJECTIVES: Since it is uncommon in children, many aspects of the disease remain discussable. With this review, we aimed to revise recent findings and new developments in this rare condition...
April 22, 2018: Current Rheumatology Reviews
Sevdalina Nikolova Lambova, Ulf Muller-Ladner
No abstract text is available yet for this article.
April 20, 2018: Current Rheumatology Reviews
Gloria Albert, Milagros Ricse, Javier Narvaez, Jesus Rodriguez-Moreno, Joan M Nolla, MAngeles Dominguez-Luzon, Carmen Gomez-Vaquero
Objetive: Patients with Rheumatoid Arthritis (RA) and nasal carriers of Staphylococcus aureus have an increased risk of developing infections caused by S. aureus. Our objective was to determine the prevalence of S. aureus nasal colonization in patients with RA and its relationship to RA treatments. METHODS: Two hundred and seven patients with RA and 37 healthy controls were prospectively included in a cross-sectional study. A nasal secretion sample was collected by swab from both anterior nostrils and was referred to the hospital's microbiology department for culturing...
April 20, 2018: Current Rheumatology Reviews
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