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Current Rheumatology Reviews

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https://www.readbyqxmd.com/read/28523993/acquired-hemophilia-as-initial-presentation-in-a-patient-with-systemic-lupus-erythematosus
#1
Zohre Khodamoradi, Mohammad Ali Nazarinia, Somaye Bazdar
BACKGROUND: Acquired hemophilia is a rare bleeding disease but may be associated with some autoimmune diseases. Acquired hemophilia may be the result of autoantibodies against factor VIII. CASE PRESENTATION: In this study, we describe a 55 year old patient who developed hematoma and hematuria due to acquired hemophilia secondary to systemic lupus erythematosus(SLE). Then, she developed arthritis and thrombosis after some evaluation. Laboratory data showed prolonged aPTT, normal PT and platelet, low FVIII, high FVIII inhibitor, ANA, anti-ds-DNA and anti-cardiolipin...
May 19, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28521689/relationship-between-rheumatoid-arthritis-disease-activity-assessed-with-the-us7-score-and-quality-of-life-measured-with-questionnaires-haq-eq-5d-wpai
#2
Martina Skácelová, Skácelová Martina, Horák Pavel, Heřmanová Zuzana, Langová Kateřina
BACKGROUND: Rheumatoid arthritis is a chronic disease considerably affecting the quality of life of patients, their functional abilities and capability to work. In everyday clinical practice, the condition is commonly monitored by assessing the disease activity using a joint count and laboratory markers of inflammation with calculating the DAS28 or other systems for scoring the disease activity. OBJECTIVES: This study is aimed to evaluate the benefit of ultrasound examination with a standardized instrument and correlate its results with the quality of life of patients and their functional abilities as assessed by standardized questionnaire methods...
May 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28521688/vasculitis-following-influenza-vaccination-a-review-of-the-literature
#3
Toru Watanabe
BACKGROUND: Influenza vaccine is safe and effective for the general population as well as for patients with autoimmune diseases. However, although rare, vasculitis has been reported as an adverse event following influenza vaccination. OBJECT: The aims of this literature review were to identify patients who developed vasculitis following influenza vaccination and to clarify the clinical manifestations of vasculitis in these patients. METHODS: Using the PubMed database and search engine, we performed a search of the English-language literature by combining the term influenza vaccination with each term for a specific form of vasculitis from January 1966 through April 2016...
May 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28464770/work-ability-in-fibromyalgia-an-update-in-the-21st-century
#4
Annie Palstam, Kaisa Mannerkorpi
Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. People with FM also report activity limitations and impaired work ability.This article aims to compile the findings of recently published research on work ability in people with fibromyalgia, and to present how work ability is influenced by various aspects. A systematic search of the literature published from the year 2000 and onwards was conducted. Thirtyfour articles were included in the review. Symptom severity was found to influence work ability in people with FM...
May 2, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28460627/synovial-fluid-and-serum-concentrations-of-inflammatory-markers-in-rheumatoid-arthritis-psoriatic-arthritis-and-osteoarthitis-a-systematic-review
#5
Emma Altobelli, Paolo Matteo Angeletti, Domenico Piccolo, Rossella De Angelis
The aim of this review is to investigate systematically the presence of the most extensively studied synovial fluid (SF) and/or serum markers in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and osteoarthritis (OA) their associations and correlations with laboratory and clinical data, with a view to providing insights for future research. Papers were selected using the PRISMA flow-chart. Search of the electronic databases according to the above criteria found a total of 55 papers. Examination led to the exclusion of 39 papers...
April 27, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28443513/the-gastrointestinal-dysmotility-and-infections-in-systemic-sclerosis-a-real-world-scenario
#6
Shefali Khanna Sharma, M B Adarsh, Saroj K Sinha, Anish Bhattacharya, Satyavati Rana, Surjit Singh, Varun Dhir
INTRODUCTION: Systemic Sclerosis is known to involve the gastrointestinal system and can lead to multitude of problems predominantly affecting the GI motility. METHODS: It was a prospective, observational, single centre study of fifty consecutive patients with SSc who presented to rheumatology clinic. Gut score was assessed using UCLA SCTC GIT 2.0 questionnaire. 35 patients underwent esophago- gastro duodenoscopy(UGIE), 31 underwent esophageal manometry, 37 underwent lactulose breath test to assess orocaecal transit time (OCTT) and glucose breath test for detecting small intestinal bacterial overgrowth (SIBO) and 36 underwent gastric emptying scintigraphy to measure gastric emptying time...
April 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28443512/clinical-and-radiographic-features-of-knee-osteoarthritis-of-elderly-patients
#7
Hana Sahli, Aicha Ben Tekaya, Selim Daas, Ines Mahmoud, Rawdha Tekaya
BACKGROUND: Knee osteoarthritis is a common pathology, characterized by a prevalence that increases with age. Absence of anatomo-clinical correlation its management complex, particularly in a geriatric setting where it is not well studied. OBJECTIVE: The aim of the present study is to investigate the epidemio-clinical profile, functional impairment and radiographic features of knee osteoarthritis in the old patients versus younger patients (<65 years). METHODS: Cross-sectional study including patients who were monitored for 6 months at a rheumatology department for knee osteoarthritis...
April 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28413989/anatomical-wrist-patterns-on-plain-radiographs
#8
Aviv Kramer, Raviv Allon, Alon Wolf, Tal Kalaiman, Idit Lavi, Ronit Wollstein
BACKGROUND: Interpreting the structure in the wrist is complicated by the existence of multiple joints as well as variability in bone shapes and anatomical patterns. Previous studies have evaluated lunate and capitate shape in an attempt to understand functional anatomical patterns. OBJECTIVE: The purpose of this study was to describe anatomical shapes and wrist patterns in normal wrist radiographs. We hypothesized that there is a significant relationship in the midcarpal joint with at least one consistent pattern of wrist anatomy...
April 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28403797/is-the-treatment-with-biological-or-non-biological-dmards-a-modifier-of-periodontal-condition-in-patients-with-rheumatoid-arthritis
#9
Consuelo Romero-Sanchez, Constanza Rodríguez, Pedro Santos, Ana María Mesa, Gloria Inés Lafaurie, Sebastian Giraldo, Juliette De Avila, Diana Marcela Castilla, Michelle Durán, Philippe Chalem, Juan Manuel Bello, Rafael Valle
BACKGROUND AND OBJECTIVE: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity. MATERIALS AND METHODS: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-α and 115 with only DMARDs)...
April 7, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28393709/profile-of-patients-with-spondyloarthritis-in-morocco
#10
Jamila Essouiri, Abourazzak Fatima Ezzahra, Kona Irene, Khoussar Ikram, Harzy Taoufik
OBJECTIVES: to describe the characteristics of our population with spondyloarthritis: diagnostic time, clinical manifestations and laboratory investigations, activity, functional impairment, severity and therapeutic management. The authors were also interested to investigate factors associated with severe disease. METHODS: A retrospective observational study, conducted in the rheumatology department at university hospital center Hassan II of Fez, analyzing the records of patients diagnosed as spondylarthritis during the period extending from January 2009 to June 2014...
April 6, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28356052/the-limitations-of-gram-stain-microscopy-of-synovial-fluid-in-concomitant-septic-and-crystal-arthritis
#11
Paul Stirling, Mohammed Tahir, Henry Dushan Atkinson
BACKGROUND: Rapid diagnosis of septic arthritis from Gram-stain microscopy is limited by an inherent false-negative rate of 25-78%. The presence of concomitant crystal arthritis in 5% of cases represents a particular diagnostic challenge. OBJECTIVE: This study aims to investigate the effects that a concomitant crystal arthropathy have on the ability of Gram-stain microscopy of synovial fluid to diagnose a septic arthritis. METHODS: This is a 12-year retrospective cohort study...
March 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28356051/the-frequency-of-hla-b27-in-a-colombian-population-with-signs-of-spondyloarthritis
#12
Consuelo Romero-Sánchez, Lorena Chila, Alberto Gómez, María Consuelo Casas, Wilson Bautista-Molano, Ignacio Briceño, Juan Camilo Rueda, Juliette De Avila, John Londoño, Rafael Valle
BACKGROUND: The strong association between HLA-B27 and spondyloarthritis (SpA) has demonstrated that typing the HLA-B27 antigen is a crucial step in diagnosis and aids in defining the progression and severity of disease. OBJECTIVE: To describe the frequency of HLA-B27 in Colombian individuals with clinical manifestations associated with SpA. MATERIALS AND METHODOLOGY: We retrospectively analyzed 4109 HLA-B27 typing requests to the Hospital Militar Central and the Instituto de Referencia Andino from Colombian individuals with clinical signs suggestive of SpA between 2009 and 2012...
March 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28325149/low-dose-naltrexone-in-the-treatment-of-fibromyalgia
#13
Samy K Metyas, Karen Yeter, John Solyman, Daniel Arkfeld
Fibromyalgia is a chronic pain disorder characterized by diffuse musculoskeletal pain, fatigue, sleep disturbance and cognitive impairment. A significant number of fibromyalgia patients do not respond adequately to the current drugs (pregabalin, milnacipran, duloxetine) approved for fibromyalgia treatment by the Food and Drug Administration (FDA). Thus, there is still a need for adjunctive therapies. Naltrexone is an opioid receptor antagonist used to treat alcohol and opioid dependence. It is hypothesized that low dose naltrexone causes transient blockade of opioid receptors centrally resulting in a rebound of endorphin function which may attenuate pain in fibromyalgia...
March 21, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28317489/ankylosing-spondylitis-and-pregnancy-a-literature-review
#14
Eirini Giovannopoulou, Grigorios Gkasdaris, Stylianos Kapetanakis, Emmanuel Kontomanolis
Ankylosing Spondylitis (AS) is the prototype of a group of systemic rheumatic diseases collectively referred to as Spondyloarthitides (SpA). It is has recently become clear that AS is not as rare as previously thought and, although it has an early onset in life affecting patients in their reproductive years, it has not been proved to adversely affect fertility in females. Furthermore, new pharmaceutical agents have been introduced for its therapeutical management. The interaction between systematic rheumatic diseases and pregnancy has been under investigation with the majority of studies focusing on systemic lupus erythematosus and rheumatoid arthritis (RA)...
March 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28292255/subcutaneous-igg-in-the-myositis-spectrum-disorders
#15
Maria Giovanna Danieli, Chiara Gelardi, Veronica Pedini, Francesco Logullo, Armando Gabrielli
The efficacy of subcutaneous immunoglobulin is reported in several neurological disorders and, more recently, its use has been extended to other inflammatory diseases, such as the idiopathic inflammatory myopathies, including polymyositis and dermatomyositis. Due to the rarity of these disorders, the role of immunoglobulin, administered intravenously or subcutaneously, remains unclear and poorly investigated. We report our experience about the use of subcutaneous immunoglobulin in myositis spectrum disorders, from idiopathic inflammatory myopathies to more complex conditions, such as overlap and cancer-associated myositis or pregnancy...
March 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28292254/impact-of-joint-involvement-on-patients-reported-outcomes-in-systemic-lupus-erythematosus
#16
Chiara Tani, Linda Carli, Andrea Delle Sedie, Lucrezia Riente, Sabrina Vagnani, Rosaria Talarico, Alessandra Della Rossa, Chiara Baldini, Stefano Bombardieri, Marta Mosca
OBJECTIVE: Joint involvement is common among patients with systemic lupus erythematosus (SLE). Aim of this work was to evaluate the correlation between the presence of joint involvement and patient-reported pain, perception of disease activity, general health and quality of life. METHODS: Fifty consecutive SLE patients were enrolled in the study. All patients underwent a complete clinical evaluation including a 44 joint count, in addition an ultrasound evaluation of joint involvement of hands and wrists was performed...
March 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28294069/wallet-neuritis-an-example-of-peripheral-sensitization
#17
Md Abu Bakar Siddiq, Israt Jahan, Sam Masihuzzaman
BACKGROUND: Wallet neuritis is an example of extra-spinal tunnel neuropathy concerning sciatic nerve. Its clinical appearance often gets confused with sciatica of lumbar spine origin. Wallet-induced chronic sciatic nerve constriction produces gluteal and ipsilateral lower extremity pain, tingling, and burning sensation. It was Lutz, first describing credit-card wallet sciatica in an Attorney, surfaced on Journal of American Medical Association (JAMA), 1978; however, the condition has not been well-studied in various other occupations...
March 9, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28124612/unique-phenotypes-and-functions-of-follicular-helper-t-cell-and-regulatory-t-cell-in-sj%C3%A3-gren-s-syndrome
#18
Masako Saito, Kunihiro Otsuka, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Naozumi Ishimaru
Sjögren's syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune responses including cellular and humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes and impaired functionality have been reported to play important roles in the cellular mechanisms of autoimmunity in SS patients and animal models of SS...
January 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28117013/gray-scale-and-power-doppler-ultrasonographic-findings-in-the-assessment-of-disease-activity-and-their-correlation-with-disease-activity-parameters-in-rheumatoid-arthritis
#19
Sandeep Jindal, Reshma Kaushik, Shailendra Raghuvanshi, Rajeev Mohan Kaushik, Rajesh Kakkar
OBJECTIVES: To study the utility of gray scale and power Doppler ultrasonography in assessing the disease activity and correlation of ultrasonographic findings with disease activity parameters in rheumatoid arthritis (RA). MATERIALS AND METHODS: This cross-sectional study was conducted on 100 RA patients diagnosed as per 2010 classification criteria. Rheumatoid factor (RF), serum anti-cyclic citrullinated peptide antibodies (ACPA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score with 28-joint counts and ESR (DAS28-ESR), visual analogue scale (VAS) for global disease activity and gray scale ultrasonography (GSUS) and power Doppler ultrsonography (PDUS) scores in hands and wrists were determined...
January 19, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28056736/investigation-of-associations-between-autoimmunity-associated-variants-in-pdcd1-and-juvenile-idiopathic-arthritis
#20
Christina I Tejeda, K Alaine Broadaway, Milton R Brown, Lori A Ponder, Michael J Ombrello, Mina Rohani Pichavant, Gabriel Wang, Sheila T Angeles-Han, Aimee O Hersh, John F Bohnsack, Karen N Conneely, Michael P Epstein, Sampath Prahalad
PURPOSE: Variants in the gene encoding Programmed Cell Death-1 (PDCD1) have been associated with susceptibility to Systemic Lupus Erythematosus and other autoimmune diseases. Given that clinically distinct autoimmune phenotypes share common genetic susceptibility factors, variants in PDCD-1 were tested for a possible association with Juvenile Idiopathic Arthritis (JIA). METHODS: Four single nucleotide polymorphisms (SNPS) in the PDCD1 gene were genotyped and analyzed: rs10204525, rs7568402, rs7421861 and rs11568821 in 834 cases and 855 self-identified Caucasian controls...
January 4, 2017: Current Rheumatology Reviews
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