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Current Rheumatology Reviews

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https://www.readbyqxmd.com/read/28124612/unique-phenotypes-and-functions-of-follicular-helper-t-cell-and-regulatory-t-cell-in-sj%C3%A3-gren-s-syndrome
#1
Masako Saito, Kunihiro Otsuka, Aya Ushio, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Naozumi Ishimaru
Sjögren's syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune responses including cellular and humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes and impaired functionality have been reported to play important roles in the cellular mechanisms of autoimmunity in SS patients and animal models of SS...
January 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28117013/gray-scale-and-power-doppler-ultrasonographic-findings-in-the-assessment-of-disease-activity-and-their-correlation-with-disease-activity-parameters-in-rheumatoid-arthritis
#2
Sandeep Jindal, Reshma Kaushik, Shailendra Raghuvanshi, Rajeev Mohan Kaushik, Rajesh Kakkar
OBJECTIVES: To study the utility of gray scale and power Doppler ultrasonography in assessing the disease activity and correlation of ultrasonographic findings with disease activity parameters in rheumatoid arthritis (RA). MATERIALS AND METHODS: This cross-sectional study was conducted on 100 RA patients diagnosed as per 2010 classification criteria. Rheumatoid factor (RF), serum anti-cyclic citrullinated peptide antibodies (ACPA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score with 28-joint counts and ESR (DAS28-ESR), visual analogue scale (VAS) for global disease activity and gray scale ultrasonography (GSUS) and power Doppler ultrsonography (PDUS) scores in hands and wrists were determined...
January 19, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28056736/investigation-of-associations-between-autoimmunity-associated-variants-in-pdcd1-and-juvenile-idiopathic-arthritis
#3
Christina I Tejeda, K Alaine Broadaway, Milton R Brown, Lori A Ponder, Michael J Ombrello, Mina Rohani Pichavant, Gabriel Wang, Sheila T Angeles-Han, Aimee O Hersh, John F Bohnsack, Karen N Conneely, Michael P Epstein, Sampath Prahalad
PURPOSE: Variants in the gene encoding Programmed Cell Death-1 (PDCD1) have been associated with susceptibility to Systemic Lupus Erythematosus and other autoimmune diseases. Given that clinically distinct autoimmune phenotypes share common genetic susceptibility factors, variants in PDCD-1 were tested for a possible association with Juvenile Idiopathic Arthritis (JIA). METHODS: Four single nucleotide polymorphisms (SNPS) in the PDCD1 gene were genotyped and analyzed: rs10204525, rs7568402, rs7421861 and rs11568821 in 834 cases and 855 self-identified Caucasian controls...
January 4, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28049394/coexistence-of-amyloidosis-and-primary-sj%C3%A3-gren-s-syndrome-an-overview-amyloidosis-and-sj%C3%A3-gren-s-syndrome
#4
Gabriela Hernandez-Molina, David Faz-Muñoz, Miguel Astudillo-Angel, Alejandra Iturralde-Chávez, Edgardo Reyes
BACKGROUND: The association of primary Sjögren´s syndrome (SS) and amyloidosis has been recognized but scarcely assessed. OBJECTIVE: Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions. METHODS: PubMed and CINAHL databases were searched from inception until April 2016 for the key words: amyloidosis, amyloid, Sjögren's syndrome and their combinations. RESULTS: Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic...
January 3, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28034349/biological-agents-in-rheumatoid-arthritis-a-cross-link-between-immune-tolerance-and-immune-surveillance
#5
Rossella Talotta, Fabiola Atzeni, Alberto Batticciotto, Maurizio Benucci, Sara Bongiovanni, Piercarlo Sarzi-Puttini
The biological drugs have all been successfully used to treat rheumatoid arthritis (RA) and have led to fair rates of clinical remission; however, the possible occurrence of adverse events such as infectious diseases or cancers means that the patients undergoing treatment need to be closely monitored. Anti-TNF agents, first appeared in the pharmacological algorithm of RA in the early 2000s, seem to lead to a higher risk of reactivated tubercular infection than the biological agents with different mechanism of action (abatacept or rituximab)...
December 30, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27917705/efficacy-of-argane-oil-on-metabolic-syndrome-in-a-moroccan-knee-osteoarthritis-population
#6
Jamila Essouiri, Fatima Ezzahra Abourazzak, Faiza Lazrak, Adil Najdi, Nadia Benaicha, Taoufik Harzy, Mourad Errasfa
Five medical conditions characterizes metabolic syndrome: abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoproteins cholesterol. When a patient has three of the five above parameters, he is called to have metabolic syndrome, and these conditions represents a key element in cardiovascular diseases. On the other hand, knee osteoarthritis is a degenerative disease which was shown to be affected by some of the parameters of metabolic syndrome...
December 4, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27908254/shoulder-in-rheumatoid-arthritis-and-its-surgical-options
#7
Nuri Aydin, Lercan Aslan, Janne Lehtinen, Vedat Hamuryudan
Shoulder arthritis due to rheumatoid arthritis is effecting 50% of the patients, but the treatment indications still carry contraversies. The literature had shown that with the optimal selection of indications, patients' morbidity can be improved. In this review, treatment modalites are widely discussed according to the patients' demand, functional status and correct order of treatments.
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#8
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27903225/weight-bearing-joints-destruction-in-rheumatoid-arthritis
#9
Takashi Imagama, Atsunori Tokushige, Kazushige Seki, Toshihiko Taguchi
In many cases of rheumatoid arthritis (RA) joints of the upper extremities are affected. However, involvement of weight bearing joints of the lower extremities is strongly associated with a decreased activities of daily living ability such as gait disorder. Once the progression of weight bearing joint destruction occurs, lower extremity function will decrease even if RA disease activity is improved by pharmacotherapy. In this article, we investigated joint destruction-suppressing effects of pharmacotherapy on the hip and knee joints, as well as risk factors for joint destruction...
November 30, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27894239/do-the-biologic-agents-increase-the-risk-of-infection-in-patients-undergoing-lower-limb-arthroplasty-surgery
#10
N A Sandiford
BACKGROUND: Biologic agents have contributed significantly to the management of patients with in rheumatoid arthritis (RA). A significant proportion of patients with RA still require arthroplasty procedures however. It is unclear whether these agents increase the risk of post operative infection after lower limb arthroplasty . The aim of this review is to review the contemporary literature about this topic along with the recommendations from specialist societies. METHOD: A literature search was performed for articles published over the last 10 years in the English language examining the association between anti-tumour necrosis factor inhibitors and the incidence of post operative infection in patients with RA undergoing hip and knee arthroplasty procedures...
November 27, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27894238/anatomical-approach-to-clinical-problems-of-popliteal-fossa
#11
Gautam Dagur, Jason Gandhi, Noel Smith, Sardar Ali Khan
BACKGROUND: Popliteal fossa, also known as the popliteal space, is located behind the knee joint. This region can develop many clinical complications in the vascular, nervous, lymphatics, adipose, as well as swelling and masses. OBJECTIVE: The objective of this review article is to give a detailed understanding of the popliteal fossa and the clinical pathology that may present itself. METHODS: MEDLINE® searches were conducted of literature published since 1950s for "popliteal fossa," "diseases," "anatomy," "arterial," "venous," "nerves," "entrapment syndrome," "aneurysms," "cysts," "lymphatics," "solid masses," "tumors," "inflammatory lesions," and "swellings...
November 27, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27881058/relationship-between-systemic-lupus-erythematosus-activity-and-persistent-positive-antiphospholipid-antibodies
#12
Zhaleh Shariati Sarabi, Maryam Sahebari, Ali Etemad Rezaie, Mohammadtaghi Norouzi, Kamila Hashemzadeh
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder, characterized by producing different auto-antibodies and multiorgan involvements. In this study we aimed to investigate the relationship between SLE activity and persistently positive antiphospholipid antibodies. Fifty-nine lupus patients (55 women and 4 men) who were assessed in two consecutive visits with 6 weeks interval were selected. Patients` clinical and laboratory data and serum antiphospholipid antibodies` values, were collected. Serum anticardiolipin antibodies and lupus anticoagulant were measured in two visits...
November 22, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27804864/immunology-rheumatology-approach-to-sudden-sensorineural-hearing-loss
#13
Mohsen Rajati, Massod Saghafi, Houshang Rafatpanah, Bashir Rasoulian, Shirin Irani, Mohammadsaleh Soltankhah
BACKGROUND: Sensorineural hearing loss (SNHL) and vestibular dysfunction have been described in various autoimmune disorders and systemic vasculitides. A high prevalence of SNHL is reported to occur in established rheumatologic diseases; however, immunologic and rheumatologic disorders make up a small proportion of patients with sudden sensorineural hearing loss (SSNHL). OBJECTIVE: This prospective study was carried out in order to determine the prevalence of rheumatologic and immunologic disorders in patients with SSNHL in Northeast Iran...
October 29, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27804863/candidate-biomarkers-for-fatigue-in-systemic-lupus-erythematosus-a-critical-review
#14
Mary A Mahieu, Rosalind Ramsey-Goldman
Fatigue impacts 80-90% of patients with systemic lupus erythematosus (SLE), and an incomplete understanding of fatigue mechanisms limits effective treatment. Disease activity indices and laboratory markers inconsistently correlate with fatigue severity in SLE populations. Identification of fatigue biomarkers has important implications for understanding pathogenesis and defining novel therapeutic targets, but a paucity of evidence exists for fatigue biomarkers in SLE. The evidence for adipokines, reduced glutathione, iron deficiency, and vitamin D as potential biomarkers for SLE-related fatigue are reviewed...
October 29, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27784233/physiotherapy-for-ankylosing-spondylitis-systematic-review-and-a-proposed-rehabilitation-protocol
#15
Deepak Sharan, Joshua Samuel Rajkumar
Ankylosing Spondylitis (AS) is a chronic inflammatory disease of insidious onset, mostly affecting the axial skeleton. It leads to varying degrees of restricted spinal mobility, pain and loss of functional capacity. Rehabilitation, especially Physiotherapy and exercises, are considered integral components of its management. Various rehabilitation modalities are available for the benefit of individuals with AS, but a sequenced protocol has not been reported. A scientific review was performed using the following search engines: MEDLINE (Pubmed), COCHRANE Library and Physiotherapy Evidence Database (PEDro)...
October 25, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27839505/a-literature-review-of-eosinophilic-fasciitis-with-an-illustrated-case
#16
Joyutpal Das, Hector Chinoy, Jeremy Dick, Rachael Matthews, Mark Roberts
Eosinophilic fasciitis (EF), a rare connective tissue disorder, was first reported by Lawrence Shulman in 1974. Since then over 300 cases have been reported worldwide. EF has variable clinical presentations and currently does not have internationally accepted diagnostic criteria. Dermatological features are the most ubiquitously present symptoms. It often presents with scleroderma-like skin changes. Extracutaneous presentations, such as arthritis and carpal tunnel syndrome can precede cutaneous changes. The most useful clinical features are the lack of Raynaud's phenomenon, telangiectasia and visceral involvement, differentiating it from Scleroderma...
October 7, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27655626/the-inflammatory-fibromyalgia
#17
Samy Metyas, Tamer Rezk, Daniel Arkfeld, Thomas Leptich
Generalized pain with tender points in specific areas accompanied by systemic symptoms such as fatigue and stiffness is characteristic of fibromyalgia (FM) syndrome. The genesis of FM is still being investigated with conflicting data on factors including autonomic dysfunction, neurotransmitters, and hormones often in combination with external stressful events. However, recent research is starting to suggest that there is a previously underappreciated subtype of fibromyalgia called inflammatory Fibromyalgia (iFM)...
September 19, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27632984/synovial-inflammation-drives-structural-damage-in-hand-osteoarthritis-a-narrative-literature-review
#18
Luana Mancarella, Olga Addimanda, Carlotta Cavallari, Riccardo Meliconi
BACKGROUND: Ultrasound is one of the most promising candidates for detection of inflammation and structural damage in hand osteoarthritis. OBJECTIVE: To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment. METHODS: We conducted a Medline on PubMed search for articles about "ultrasonography" and "hand OA" published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving inflammatory diseases, visualization of joints other than hands, ultrasound guided injections and surgical procedures...
September 9, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27632985/the-relationship-between-focal-and-generalized-bone-loss-in-rheumatoid-arthritis
#19
Allen P Anandarajah, Muhammad El-Taha, Cheng Peng
OBJECTIVE: To determine if there is an association between focal and systemic bone loss in patients with RA. METHODS: Bone loss is a hallmark finding in rheumatoid arthritis (RA) and manifests as localized, periarticular and systemic bone loss. RA patients were selected from the Consortium of Rheumatology Researchers of North America (CORRONA) database. Multiple logistic regression models were constructed to assess the association between the presence or absence of erosions and T-scores at the lumbar spine (LS) and total hips and adjusted for age, gender, body mass index (BMI), medications and disease activity indices...
September 8, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27604889/localized-scleroderma-a-clinical-review
#20
Kirk Sperber, Julia Ash, Farrah Gutwein, Amy Wasserrman, Varuni Rao, Mark Tratenberg
Localized scleroderma (LS) is characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissue or both. The outcome for most patients with localized scleroderma depends upon the type and extent of the lesion. The major challenge for untreated patients is not survival but morbidity due to skin, muscle and bone atrophy resulting in growth defects. Treatment is individualized to type and stage of the lesion and may include pharmacologic and non-pharmacologic therapies. Among the pharmacologic modalities, methotrexate with systemic glucocorticoids is currently the mainstay of treatment...
September 7, 2016: Current Rheumatology Reviews
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