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Current Rheumatology Reviews

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https://www.readbyqxmd.com/read/29779484/genetics-and-epigenetics-pathogenesis-of-beh%C3%A3-et-s-syndrome
#1
Jibran Sualeh Muhammad, Muhammad Ishaq, Khalid Ahmed
Behçet's syndrome (BS) is characterized numerous systemic manifestations, is known for its ability to affect both, arteries and the veins. However, the etiology of BS is only partially understood, and previous studies have demonstrated a role of genetic and epigenetic factors contributes to disease pathophysiology. Several studies have implicated the T cells and monocytes, especially when stimulated by seat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in lymphocyte proliferation, maturation, and differentiation, is activated in Behçet's syndrome...
May 20, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29766817/characteristics-and-outcomes-of-patients-with-anti-glomerular-basement-membrane-antibody-disease-and-anti-neutrophil-cytoplasmic-antibodies
#2
Percy Balderia, Nicole Andeen, Jonathan Ashley Jefferson
BACKGROUND: It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called "double-positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone...
May 16, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29756580/subtypes-of-antiphospholipid-antibodies-in-neurologic-accidents-an-observational-study
#3
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29708075/risk-factors-associated-with-musculoskeletal-injury-a-prospective-study-of-british-infantry-recruits
#4
Jagannath Sharma, R Heagerty, S Dalal, B Banerjee, T Booker
BACKGROUND: Musculoskeletal injury (MSKI), a common problem in both military and physically active civilian populations has been suggested to result from both extrinsic and intrinsic factors. OBJECTIVE: This study was to investigate prospectively whether gait biomechanics, aerobic fitness level and smoking status as well as entry military selection test variables can be used to predict MSKI development during recruit training. METHOD: British infantry male recruits (n = 562) were selected for the study...
April 29, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29692254/musculoskeletal-manifestations-of-sarcoidosis-a-review-article
#5
Somayeh Shariatmaghani, Roshanak Salari, Maryam Sahebari, Payman Shalchiantabrizi, Masoumeh Salari
Sarcoidosis is a multisystem inflammatory disease with an etiology that is not clearly understood. Amongst the different organs that may be affected, the lungs are the most common. Musculoskeletal manifestations of the disease are uncommon. They include arthropathy, bone lesions, or myopathy, all of which may occur as initial symptoms or develop during the course of the disease. Articular involvement my present as arthralgia or arthritis. Skeletal complications usually develop in the chronic state of the disease...
April 24, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29692256/gauzoma-in-a-scleroderma-patient-following-open-heart-surgery-a-case-report
#6
Mohammadali Nazarinia, Elmira Esmaeilzadeh
INTRODUCTION: Gauzoma is an iatrogenic complication, which occurs rarely due to surgical team negligence. Depending on the sterility of the retained tissue, it can lead to life threatening surgical complications or may remain asymptomatic for many years and be detected incidentally in imaging studies. It may be mistaken as tumors or aneurysms. Thus, high clinical suspicion is needed to diagnose them in patients with past history of operation. Reporting Case: A 35 years old woman, a known case of scleroderma underwent open-heart surgery 20 years before being diagnosed as scleroderma, presented by dyspnea especially on activity...
April 22, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29692255/juvenile-scleroderma-what-has-changed-in-the-meantime
#7
Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
BACKGROUND: Juvenile scleroderma is a rarely seen chronic connective tissue disorder characterized by stiffening of the skin. The frequency of the disease was reported as one per million. According to organ involvement, the disease is divided into two main forms: systemic and localized scleroderma. OBJECTIVES: Since it is uncommon in children, many aspects of the disease remain discussable. With this review, we aimed to revise recent findings and new developments in this rare condition...
April 22, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29663891/flipped-learning-can-rheumatology-lead-the-shift-in-medical-education
#8
Yasser El Miedany, Maha El Gaafary, Nadia El Aroussy, Sally Youssef
OBJECTIVE: To: 1. implement flipped classroom rheumatology teaching for undergraduate education. 2. Evaluate outcomes of teaching using OSCE assessment and student perceived effectiveness and satisfaction survey. METHODS: The flipped classroom education was conducted in 3 phases. Phase 1: carried out in the students' own time. Web links were emailed to assist exposure of the instructional part of the lesson online. Phase 2: interactive in-class activity to share personal reflection and reinforce the key aspects...
April 16, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29637864/future-perspectives-in-the-diagnosis-of-neuropsychiatric-lupus-by-advanced-magnetic-resonance-imaging-techniques
#9
Ricard Cervera, Nicolae Sarbu, Mihaela Ionela Sarbu, Nuria Bargallo
Neuropsychiatric (NP) syndromes are an important cause of morbi-mortality in patients with systemic lupus erythematosus (SLE). Despite remarkable recent progress, there are no definite methods to diagnose neuropsychiatric SLE (NPSLE) or to differentiate primary NPSLE from secondary causes. NPSLE remains a diagnosis of exclusion, and the clinical judgment is still the main approach to the correct diagnosis. Within this complex context, the magnetic resonance imaging (MRI) has both a diagnostic role, by showing the nervous system involvement on one hand and excluding other causes on the other hand, and a prognostic role, helping assessing the lesions and monitoring the evolution...
April 10, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29637865/clinico-epidemiological-study-of-morphea-from-a-tertiary-care-hospital
#10
Tasleem Arif, Mohammad Adil, Syed Suhail Amin, Mohammad Tahseen, Konchok Dorjay, Mohd Mohtashim, Manu Singh, Roopal Bansal, Dinesh Raj
INTRODUCTION: Morphea is an uncommon disease that presents with skin induration and sclerosis. The disease is common in Caucasians and there are few studies describing the clinico-epidemiological profile of these patients from the Indian subcontinent. METHODS: This prospective study was conducted during a three year period from June 2014 to May 2017. All patients of morphea presenting to the dermatology outpatient department were evaluated for parameters like age, sex, duration, age of onset, clinical subtype and possible disease associations and triggering factors...
April 9, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29623847/adenosine-deaminase-activity-and-hla-drb-as-diagnostic-markers-for-rheumatoid-arthritis
#11
Shirin Valadbeigi, Mina Ebrahimi-Rad, Shohreh Khatami, Hadi Akhbari, Reza Saghiri
BACKGROUND AND OBJECTIVE: Rheumatoid Arthritis (RA) is a chronic multi systemic disorder with the unclarified ethiopathology. Although several markers have been presented for recognition of RA, but none of them has been specific. New markers such as HLA typing and activity of Adenosine deaminase (ADA) isoenzymes could be useful and specific. The aim of this study is to evaluate the pattern of ADA isoenzymes activity and HLA typing in both RA patients and healthy cases. METHODS: Blood samples were collected from 55 RA patients and 60 healthy subjects, over a period of 6 months...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29623846/immune-mediated-necrotizing-myopathy-where-do-we-stand
#12
Abdel Gaffar A Mohammed, Ayanda Gcelu, Farzana Moosajee, Stella Botha, Ali Asgar Kalla
Immune-mediated necrotizing myopathies (IMNMs) are a group of acquired autoimmune muscle disorders that have been recently defined. They are characterized by proximal muscle weakness, high levels of creatinine kinase, and myopathic findings on electromyogram (EMG). Muscle biopsy in IMNM differentiates it from the other subgroups of idiopathic inflammatory myositis (IIM) by the presence of myofibre necrosis and prominent regeneration without substantial lymphocytic inflammatory infiltrates. Anti-signal recognition particle (SRP) and anti-3hydroxy-3 methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies were found in two thirds of IMNM patients...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29623845/is-treat-to-target-in-lupus-nephritis-realistic-in-clinical-practice
#13
Chi Chiu Mok
The treat-to-target (T2T) principle has been advocated in a number of inflammatory and non-inflammatory medical illnesses. Tight control of disease activity has been shown to improve the outcome of rheumatoid arthritis and psoriatic arthritis as compared to the conventional approach. However, whether T2T can be applied to patients with lupus nephritis is still under hot discussion. Treatment of lupus nephritis should target at inducing and maintaining remission of the kidney inflammation so as to preserve renal function and improve survival in the long-term...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29557752/laboratory-assessment-in-patients-with-suspected-rheumatic-musculoskeletal-diseases-challenges-pitfalls-and-perspectives
#14
Francesco Carubbi, Alessia Alunno, Paola Cipriani, Onelia Bistoni, Rosa Scipioni, Vasiliki Liakouli, Piero Ruscitti, Onorina Berardicurti, Salvatore Di Bartolomeo, Roberto Gerli, Roberto Giacomelli
Current patient care in rheumatology relies primarily on a combination of traditional clinical assessment and standard laboratory tests. Investigators seek to discover new biomarkers and novel technologies such as the 'omics' boosted the research in this field. Mechanistic biomarkers such as cytokines, cell types, antibodies, signaling molecules, are rooted in the mechanism underlying the disease and can guide the clinical management of the disease. Conversely, descriptive biomarkers are byproducts of the disease process, depict the state of a disease but are not involved in its pathogenesis...
March 19, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29446745/editorial-nailfold-capillaroscopy-in-rheumatology
#15
EDITORIAL
Sevdalina Nikolova Lambova, Ulf Muller-Ladner
No abstract text is available yet for this article.
April 20, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29308742/autoantibodies-and-gastrointestinal-symptoms-in-colombian-children-with-juvenile-idiopathic-arthritis
#16
Tatiana González, Clara Malagón, Pilar Guarnizo, Angela C. Mosquera, Lorena Chila-Moreno, Consuelo Romero-Sánchez
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common inflammatory joint disease in children. JIA and autoimmune inflammatory diseases of the gastrointestinal (GI) mucosa share common etiologic mechanisms, including genetic predisposition and environmental influences. OBJECTIVE: To determine the presence of autoantibodies associated with inflammatory diseases of the GI mucosa in patients with JIA and its relationship to GI symptoms. METHODOLOGY: In a cross-sectional study of patients with JIA, GI symptoms and autoantibody expression were evaluated with respect to their association with JIA disease activity indices...
January 7, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29283072/onset-of-hypertension-in-leflunamide-treated-low-socioeconomic-rheumatoid-arthritis-patients-an-unseen-iceberg
#17
Muhammad Ishaq, Salma Razzaque, Fadieleh Shohail, Ajeet Kumar, Jibran Sualeh Muhammad
OBJECTIVE: To determine the frequency of new-onset hypertension in patients with Rheumatoid arthritis taking leflunomide, in comparison with methotrexate in Asian setting. MATERIAL AND METHODS: Perspective case-control study was conducted in 2014 in a tertiary care hospital located in Karachi Pakistan. Adult patients having rheumatoid arthritis were randomly prescribed leflunomide or methotrexate. Patients having chronic hypertension, proteinuria and chronic kidney disease were excluded...
December 27, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29057725/prevalence-of-nasal-colonization-with-staphylococcus-aureus-in-patients-with-rheumatoid-arthritis
#18
Gloria Albert, Milagros Ricse, Javier Narvaez, Jesus Rodriguez, Joan Miquel Nolla, Mari Angeles Dominguez-Luzon, Carmen Gomez-Vaquero
OBJECTIVE: Patients with rheumatoid arthritis (RA) and nasal carriers of Staphylococcus aureus have an increased risk of developing infections caused by S. aureus. Our objective was to determine the prevalence of S. aureus nasal colonization in patients with RA and its relationship to RA treatments. METHODS: Two hundred seven patients with RA and 37 healthy controls were prospectively included in a cross-sectional study. A nasal secretion sample was collected by swab from both anterior nostrils and was referred to the hospital's microbiology department for culturing...
October 20, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29046162/potential-role-of-rebamipide-in-osteoclast-differentiation-and-mandibular-condylar-cartilage-homeostasis
#19
Takashi Izawa, Islamy Rahma Hutami, Eiji Tanaka
Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that involves changes in subchondral bone and progressive degradation of cartilage. Currently, rebamipide, a gastroprotective drug, is administered to protect gastric mucosa and accelerate ulcer healing. Recent studies have shown that rebamipide also attenuates cartilage degeneration by suppressing oxidative damage and inducing homeostasis of the extracellular matrix of articular chondrocytes. Regarding the latter, reduced expression of cathepsin K, NFATc1, c-Src, and integrin β3, and increased expression of nuclear factor-kappa B, have been found to be mediated by the transcription factor, receptor activator of nuclear factor kappa-B ligand (RANKL)...
October 17, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28875826/current-treatment-options-for-osteoarthritis
#20
Walter Hermann, Sevdalina Lambova, Ulf Müller-Ladner
Background: Osteoarthritis (ОА) is the most common joint disease and a leading cause for impaired function and disability with significant treatment costs and socio-economic burden. Despite recent achievements in the knowledge on disease pathogenesis, the treatment is still a challenge and contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for OA. Objectives: Despite recent achievements in the knowledge on disease pathogenesis, the treatment is still a challenge and contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for OA...
August 29, 2017: Current Rheumatology Reviews
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