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Current Rheumatology Reviews

Massoud Saghafi, Nafiseh Abdolahi, Reza Orang, Mohammad Reza Hatef, Mohammad Hadi Molseghi
BACKGROUND AND AIM: Lymphoid cell infiltration and destruction of exocrine glands, specifically lacrimal and salivary glands are characteristics of Sjogren's syndrome (SS). An etiological role has been proposed for Helicobacter pylori (H.Pylori), interacting in the clinical course and complications of SS (including gastric cancer and lymphoma). The aim of this study was to identify the probable correlation between H. pylori infection and Sjogren's syndrome (SS). METHOD: In this case-control study, ELISA method was used to determine serum level of IgA and IgM anti H...
November 12, 2018: Current Rheumatology Reviews
Maryam Sahebari, Zahra Rezaieyazdi, Mandana Khodashahi
BACKGROUND: Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases...
October 16, 2018: Current Rheumatology Reviews
Ana Isabel Ospina-Caicedo, Alex Darío Cardona-Rincon, Juan Manuel Bello-Gualtero, Rafael Valle-Onate, Consuelo Romero-Sanchez, P Chalem-Choueka Philippe, Gloria Vasquez Duque
BACKGROUND: Systemic Lupus Erythematosus [SLE] involves genetic, environmental, and hormonal alterations, including Vitamin D deficiency. OBJECTIVE: To evaluate the association between vitamin D levels with anti-dsDNA, complement proteins, immunoglobulins levels and disease activity scores Methods: A cross-sectional study was performed. The levels of 25-OH vitamin D were measured in patients older than 18 years with SLE according to ACR/97 [American College of Rheumatology 1997] from 2013 to 2015...
October 15, 2018: Current Rheumatology Reviews
Richa Modgil, Karandeep Singh Arora, Abhishek Sharma, Lalit Singh Negi, Shreeyam Mohapatra, Shubhangi Pareek
PURPOSE: The present study was conducted to evaluate the efficacy of conventional TMJ imaging in depicting osseous changes in mandibular condyle and glenoid fossa in patients with Rheumatoid arthritis and osteoarthritis by comparing the finding against CT and with an objective that if conventional TMJ imaging modality can appreciate the osseous changes in RA and OA then what is the need for CT scan. This further reducing the patient's radiation dose. MATERIALS AND METHOD: A total of 70 patients (40 Rheumatoid Arthritis; 30 Osteoarthritis) were taken in the study aged between 40 - 60 years and divided in to age groups...
September 26, 2018: Current Rheumatology Reviews
Andrew Kwan, Patricia Katz, Zahi Touma
Depression and anxiety are common neuropsychiatric complaints in patients with systemic lupus erythematosus (SLE). While numerous studies have been performed to investigate the prevalence, impact, and associated factors of depression and anxiety, current literature presents mixed results as it pertains to a number of these topics. In particular, the prevalence varies substantially between studies due to methodological limitations, and heterogeneity in defining anxiety and depression, patient selection, and metrics used...
September 25, 2018: Current Rheumatology Reviews
Ghazal Hashemi, Mahtabalsadat Mirjalili, Zahra Basiri, Ahmad Tahamoli-Roudsari, Nejat Kheiripour, Maryam Shahdoust, Akram Ranjbar, Maryam Mehrpooya, Sara Ataei
BACKGROUND: Rheumatoid arthritis (RA) is a common inflammatory disease of the joints. Due to importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties such as N-acetyl cysteine(NAC), can be effective as adjunctive therapy in patients with RA. AIMS: The aim of this study has been to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA. METHOD: Beside standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks...
September 25, 2018: Current Rheumatology Reviews
Hassan Bassiouni, Ahmed El-Atrebi, Khaled Zaky
BACKGROUND: Amyloidosis is a life threatening complication of Rheumatoid Arthritis (RA) that should be detected as early as possible to avoid its morbidity and mortality. OBJECTIVE: To detect subclinical amyloidosis in RA patients without proteinuria and a disease duration more than 5 years. PATIENTS: Eighty-six RA patients seen between October 2013 and August 2014 were recruited for the study. Those with 5 years disease duration were included in the study but those who had proteinuria, serum creatinine > 1...
September 3, 2018: Current Rheumatology Reviews
Dhruvkumar M Patel, Mukundkumar V Patel, Kamal H Sharma, Greshaben Rajeshkumar Patel, Manish B Patel, Vipul B Shah
BACKGROUND: Atherosclerosis and coronary plaque destabilization are linked to each other. Infections due to various microbes may trigger acute coronary syndrome (ACS) by systemic inflammation cascade. METHODS: We have evaluated the prevalence of Post chikungunya chronic arthritis (PCCA) among 400 consecutive ACS patients (Case group) and compared with control group subjected to elective surgery by the prospective case-control observational study. Cases were excluded if standard criteria of ACS were not satisfied and in control group if the patient suffered a myocardial infarction (MI) within 28 days of elective surgery...
August 15, 2018: Current Rheumatology Reviews
Victoria A Flower, Shaney L Barratt, Stephen Ward, John D Pauling
The pathological hallmarks of Systemic sclerosis (SSc) constitute an inter-related triad of autoimmunity, vasculopathy and tissue remodeling. Many signaling mediators have been implicated in SSc pathology; most focusing on individual components of this pathogenic triad and current treatment paradigms tend to approach management of such as distinct entities. The present review shall examine the role of vascular endothelial growth factor (VEGF) in SSc pathogenesis. We shall outline potential mechanisms whereby differential vascular endothelial growth factor-A (VEGF-A) isoform expression (through conventional and alternative VEGF-A splicing,) may influence the relevant burden of vasculopathy and fibrosis offering novel insight into clinical heterogeneity and disease progression in SSc...
August 9, 2018: Current Rheumatology Reviews
Rehab Ali Ibrahim, Nour El-Hoda Hussien Abdalla, Engy Amr Husssein Shabaan, Noha Bassiouny Hassan Mostafa
BACKGROUND: Scleroderma or systemic sclerosis (SSc) is a rare systemic autoimmune disease. Many conditions mimic the presentation of SSc, especially skin thickening and fibrosis. One of these conditions is scleredema, a rare collagen and mucin deposition disorder which was found to be associated with diabetes mellitus, streptococcal infection or monoclonal gammopathy. CASE PRESENTATION: A 55 years old female presented with insidious onset and progressive course of diffuse skin thickening of face, neck, arms, forearms, thighs, chest, back, and sparing both hands and feet of 6 years duration associated with arthralgia, dysphagia and dyspnea on exertion of 1-year duration...
August 7, 2018: Current Rheumatology Reviews
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Piercarlo Sarzi-Puttini
BACKGROUND: The presence of neuropatic pain (NeP) is common in subjects with established rheumatoid arthritis (RA), and it can influence the disease remission. These aspects have not been investigated in patients with early rheumatoid arthritis (ERA). OBJECTIVE: To investigate the effect of NeP on the achievement of remission in patients with ERA. METHOD: The study involved consecutive patients with moderately or highly active ERA (a score of >11 on the Simplified Disease Activity Index)...
August 6, 2018: Current Rheumatology Reviews
Ivan Posso-Osorio, Juan Naranjo-Escobar, Diana Marcela Loaiza, Marcela Polo, Alex Echeverri, Gabriel J Tobon
BACKGROUND: Sjögren's syndrome is an autoimmune disease characterised by exocrinopathy mainly involving the salivary and lacrimal glands. In addition, it is a multisystemic condition (i.e., affecting multiple organs and systems). Neurological involvement has been reported in ~20% of cases, with peripheral manifestations being the most frequent. METHOD: We analysed four cases in which neurological manifestations were the first symptoms of Sjögren's syndrome. RESULTS: In all four cases, neurological symptoms preceded sicca symptoms...
July 30, 2018: Current Rheumatology Reviews
Selcan Demir, Hafize Emine Sonmez, Seza OZen
In the last decade we have come to better understand and manage the vasculitides. Classification of vasculitides has been revised. Genome- wide association studies and linkage analyses have been undertaken in hope of better understanding the pathogenesis of vasculitides. Comprehensive genetic studies have highlighted new pathways that may guide us in more targeted therapies. Description of the monogenic forms of vasculitis, such as deficiency of adenosine deaminase type 2 (DADA2), haploinsufficiency of A20 (HA20), have introduced a new perspective to vasculopathies, and introduced alternative treatments for these diseases...
July 25, 2018: Current Rheumatology Reviews
Elham Rajaei, Habib Haybar, Karim Mowla, Zeinab Deris Zayeri
BACKGROUND: Rheumatoid arthritis is a widespread autoimmune disease and inflammation and bone destruction are two main issues in rheumatoid arthritis. OBJECTIVE: To discussing metformin effects on rheumatoid arthritis complications. METHOD: We conducted a narrative literature search including clinical trials, experimental studies on laboratory animals and cell lines. Our search covered Medline, PubMed and Google Scholar databases from 1999 until 2018...
July 17, 2018: Current Rheumatology Reviews
Quan-Bo Zhang, Dan Zhu, Zhong Wen, Ting Yi, Qing Li, Yu-Feng Qing, Jing-Guo Zhou
OBJECTIVE: To investigate the changes of serum uric acid (sUA), lipids and cystatin C (CysC) in primary gout patients, and to explore the clinical significance in gout patients. METHODS: sUA, CysC, high-sensitivity C-reactive protein (hsCRP) and other biochemical parameters were measured in 326 gout patient and 210 healthy control subjects, blood cell counts were also detected. Clinical data were collected from gout patients. RESULTS: sUA, CysC, hsCRP, Body Mass Index (BMI), white blood cell (WBC) counts, neutrophil granulocyte (GR), monocyte (Mo), triglycerides (TG), plasma total cholesterol (TC), very low density lipoprotein (VLDL), apolipoprotein B100 (apoB100), blood glucose (GLU), serum creatinine (sCr) and urea nitrogen (BUN) were significantly increased in gout patients compared with HC subjects (P<0...
July 4, 2018: Current Rheumatology Reviews
Asghar Zare, Mohammadali Nazarinia, Mesbah Shams, Mohammad Javad Fallahi
BACKGROUND: Systemic sclerosis (SSc) is a disorder of connective tissue affecting the skin and internal organs, characterized by fibrotic changes of peripheral and visceral architecture. OBJECTIVE: We investigated the correlation between serum concentration of homocysteine and interstitial lung involvement in SSc patients. METHOD: Fifty nine patients with SSc (53 females and 6 males) with a mean age of 43.34 years (range: 17-76 years) were enrolled...
June 28, 2018: Current Rheumatology Reviews
Y V Raghava Neelapala
Knee Osteoarthritis (OA) is a disabling musculoskeletal condition among the elderly. Self-reported instability is one of the impairments associated with osteoarthritis. A complete understanding of the self-reported instability in knee OA is essential, to identify the best strategies for overcoming this impairment. The focus of this scoping review is to provide an overview of evidence supported information about the prevalence and other associated features of self-reported instability in Knee OA. A broad search of the database PubMed with keywords such as knee osteoarthritis and instability resulted in 1075 articles...
June 27, 2018: Current Rheumatology Reviews
Jibran Sualeh Muhammad, Muhammad Ishaq, Khalid Ahmed
Behçet's syndrome (BS) is characterized numerous systemic manifestations, is known for its ability to affect both, arteries and the veins. However, the etiology of BS is only partially understood, and previous studies have demonstrated a role of genetic and epigenetic factors contributes to disease pathophysiology. Several studies have implicated the T cells and monocytes, especially when stimulated by seat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in lymphocyte proliferation, maturation, and differentiation, is activated in Behçet's syndrome...
May 20, 2018: Current Rheumatology Reviews
Percy G Balderia, Nicole Andeen, Jonathan A Jefferson
BACKGROUND: It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called "double-positive" (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone...
May 16, 2018: Current Rheumatology Reviews
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
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