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Clinical Genitourinary Cancer

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https://www.readbyqxmd.com/read/28089720/condyloma-acuminatum-of-urinary-bladder-in-a-male-renal-transplant-recipient-a-diagnostic-and-therapeutic-challenge
#1
Aruna Nambirajan, Abhishek Kumar Shukla, Sandeep R Mathur, Hemanth Kumar, Rajeev Kumar, Dipankar M Bhowmik, Ashok Singh, Deepali Jain, Mehar Chand Sharma, Seema Kaushal
No abstract text is available yet for this article.
January 4, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28108284/first-line-pazopanib-in-non-clear-cell-renal-carcinoma-the-italian-retrospective-multicenter-panorama-study
#2
Sebastiano Buti, Melissa Bersanelli, Francesca Maines, Gaetano Facchini, Francesco Gelsomino, Fable Zustovich, Matteo Santoni, Elena Verri, Ugo De Giorgi, Cristina Masini, Franco Morelli, Maria Giuseppa Vitale, Teodoro Sava, Giuseppe Prati, Carmelinda Librici, Anna Paola Fraccon, Giuseppe Fornarini, Marco Maruzzo, Francesco Leonardi, Orazio Caffo
INTRODUCTION: Pazopanib is a standard first-line treatment for metastatic clear-cell renal cell carcinoma (ccRCC). Very few data on its activity in non-clear-cell renal cell carcinoma (nccRCC) are currently available. The aim of this study was to retrospectively analyze efficacy and toxicity of pazopanib in nccRCC patients. PATIENTS AND METHODS: Records from advanced nccRCC patients (consecutive sample) treated with first-line pazopanib between 2010 and 2015 at 17 Italian centers were reviewed...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28089722/perioperative-allogenic-blood-transfusion-in-renal-cell-carcinoma-risk-factors-and-effect-on-long-term-outcomes
#3
Francesco Soria, Michela de Martino, Carmen V Leitner, Marco Moschini, Shahrokh F Shariat, Tobias Klatte
BACKGROUND: We sought to create a preoperative model to predict the risk of perioperative blood transfusion (PBT) in patients with renal cell carcinoma (RCC) undergoing nephrectomy and to evaluate the effect of PBT on long-term outcomes. PATIENTS AND METHODS: The present retrospective study included 648 consecutive patients who had undergone radical or partial nephrectomy for RCC at a single institution. The risk factors for PBT were analyzed using logistic regression analysis...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28087329/influence-of-health-and-functional-status-and-co-occurring-chronic-conditions-on-healthcare-expenditures-among-community-dwelling-adults-with-kidney-cancer-in-the-united-states-a-propensity-score-matched-analysis
#4
Sandipan Bhattacharjee, Mahdi Gharaibeh, Muhammad Umar Kamal, Irbaz Bin Riaz
BACKGROUND: Health and functional status, as well as co-occurring chronic conditions, have a profound influence on healthcare expenditures. However, no study to date has assessed their influence among community-dwelling adults with kidney cancer (KC) in the United States (US). This study assessed the impact of health and functional status, along with co-occurring chronic conditions, on KC healthcare expenditures. METHODS: This study used a retrospective, cross-sectional, propensity-score-matched, case-control study design using 2002 to 2011 Medical Expenditure Panel Survey data...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28089721/angiotensin-inhibitors-as-treatment-of-sunitinib-pazopanib-induced-hypertension-in%C3%A2-metastatic-renal-cell-carcinoma
#5
Patrick Penttilä, Juhana Rautiola, Tuija Poussa, Katriina Peltola, Petri Bono
BACKGROUND: Research suggests that baseline use of angiotensin system inhibitors (ASIs) improves outcome in patients with metastatic renal cell carcinoma (mRCC), but it remains unknown whether the type of antihypertensive medication used to initiate management at onset of treatment-induced hypertension (HTN) is associated with outcome. We evaluated the association of ASIs and outcome among patients with mRCC treated with first-line tyrosine kinase inhibitors (TKIs). PATIENTS AND METHODS: We identified 303 consecutive patients with mRCC who were treated with sunitinib or pazopanib in a single university hospital cancer center...
December 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28065536/a-rare-case-of-epididymal-metastasis-after-radical-prostatectomy-detected-by-68ga-psma-pet-ct
#6
Giulia Polverari, Francesco Ceci, Tiziano Graziani, Cesare Cozzarini, Paolo Castellucci, Stefano Fanti
No abstract text is available yet for this article.
December 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28065418/second-line-chemotherapy-in-older-patients-with-metastatic-urothelial-carcinoma-pooled-analysis-of-10-second-line-studies
#7
Samer Salah, Jae-Lyun Lee, Antonio Rozzi, Hiroshi Kitamura, Kazumasa Matsumoto, Daniel J Vis, Sandy Srinivas, Rafael Morales-Barrera, Joan Carles, Dalia Al-Rimawi, Soonil Lee, Ki Hong Kim, Kouji Izumi, Jeremy Lewin
BACKGROUND: Older patients with metastatic urothelial carcinoma (UC) are under-represented in clinical trials, and data regarding outcomes for second-line therapy is limited. MATERIALS AND METHODS: Individual data for patients with metastatic UC, aged ≥ 70 years, were pooled from 10 second-line studies. The influence of potential prognostic factors on overall survival (OS) was assessed via univariate and multivariate Cox regression analysis. RESULTS: In total, 102 patients were included; the median age was 74...
December 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28063845/comparative-assessment-of-efficacies-between-2%C3%A2-alternative-therapeutic-sequences-with-novel%C3%A2-androgen-receptor-axis-targeted-agents%C3%A2-in-patients-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer
#8
Hideaki Miyake, Takuto Hara, Keita Tamura, Takayuki Sugiyama, Hiroshi Furuse, Seiichiro Ozono, Masato Fujisawa
BACKGROUND: The objective of this study was to compare the efficacies of sequential therapies with novel androgen receptor-axis-targeted (ARAT) agents in patients with docetaxel-naïve metastatic castration-resistant prostate cancer (mCRPC). PATIENTS AND METHODS: This study included 108 consecutive patients with mCRPC who sequentially received abiraterone acetate (AA) and enzalutamide (Enz), in either order, without prior treatment with docetaxel. The combined prostate-specific antigen (PSA) progression-free survival (PFS) was defined as the sum of PFS1 and PFS2, representing PSA PFSs on the first and second ARAT agents, respectively...
December 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28040422/pure-but-not-mixed-histologic-variants-are-associated-with-poor-survival-at-radical-cystectomy-in-bladder-cancer-patients
#9
Marco Moschini, Shahrokh F Shariat, Roberta Lucianò, David D'Andrea, Beat Foerster, Mohammad Abufaraj, Marco Bandini, Paolo Dell'Oglio, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
PURPOSE: To evaluate the impact of pure and mixed histologic variant versus pure urothelial carcinoma in nonmetastatic bladder cancer (BCa) patients treated with radical cystectomy (RC). PATIENTS AND METHODS: We evaluated data from 1067 patients treated with RC and pelvic lymph node dissection between 1990 and 2013 at a single institution tertiary-care referral center. All specimens were evaluated by dedicated uropathologists. Univariable and multivariable Cox regression analyses tested the impact of the presence of pure and mixed histologic variants versus pure urothelial on recurrence, cancer-specific mortality, and overall mortality after accounting for all available confounders...
December 14, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28040423/prognostic-significance-of-increases-in-hemoglobin-in-renal-cell-carcinoma-patients-during-treatment-with-vegf-directed-therapy
#10
Abhishek Tripathi, Susanna Jacobus, Hope Feldman, Toni K Choueiri, Lauren C Harshman
BACKGROUND: Increases in hemoglobin have been reported in renal cell carcinoma (RCC) patients treated with vascular endothelial growth factor (VEGF) pathway-targeted therapies and have been associated with increased progression-free survival (PFS). We retrospectively evaluated its significance as a predictive biomarker of clinical response in RCC. PATIENTS AND METHODS: Patients with advanced RCC treated with VEGF receptor tyrosine kinase inhibitors (TKIs) or bevacizumab as a first-line therapy were identified...
December 13, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28038932/pretreatment-lymphocyte-to-monocyte-ratio-is-an-independent-prognostic-factor-in-metastatic-clear-cell-renal-cell-carcinoma
#11
Liangyou Gu, Xin Ma, Yongpeng Xie, Hongzhao Li, Lei Wang, Luyao Chen, Wenlei Zhao, Yu Zhang, Xu Zhang
BACKGROUND: The prognostic value of pretreatment lymphocyte to monocyte ratio (LMR) in metastatic clear cell renal cell carcinoma (ccRCC) is not well-described. The purpose of this study was to assess the prognostic role of pretreatment LMR in surgically treated metastatic ccRCC. PATIENTS AND METHODS: One hundred forty-five patients with metastatic ccRCC who underwent cytoreductive nephrectomy between 2006 and 2013 at our institute were identified. Pretreatment LMR was calculated within 1 week before surgical intervention...
December 13, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28038931/safety-of-same-day-pegfilgrastim-administration-in-metastatic-castration-resistant-prostate-cancer-treated-with-cabazitaxel-with-or-without-carboplatin
#12
Mehmet Asim Bilen, Diana H Cauley, Bradley J Atkinson, Hsiang-Chun Chen, Diana H Kaya, Xuemei Wang, Raghu Vikram, Shi-Ming Tu, Paul G Corn, Jeri Kim
INTRODUCTION: Although myeloid growth factors are commonly used to treat metastatic castration-resistant prostate cancer (mCRPC), the optimal timing of administration has not been well studied. We assessed the effects of same-day pegfilgrastim, a neutrophil stimulator, after cabazitaxel treatment with or without carboplatin in patients with mCRPC. We also evaluated the frequency of urinary tract inflammation during treatment. PATIENTS AND METHODS: Between September 2010 and September 2014, 151 consecutive patients with mCRPC underwent cabazitaxel treatment with or without the addition of carboplatin at a single institution...
December 13, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28017535/bilateral-testicular-metastases-and-filariasis-in-prostatic-adenocarcinoma
#13
Monica Malik, Deepa Joseph, Jyothi Jonnadula, Syed Fayaz Ahmed, Deepthi Valiyaveettil, Rama Vaghmare
No abstract text is available yet for this article.
December 7, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28063846/systematic-expression-analysis-of-mitochondrial-complex-i-identifies-ndufs1-as-a-biomarker-in-clear-cell-renal-cell-carcinoma
#14
Jörg Ellinger, Mirjam Poss, Maria Brüggemann, Arabella Gromes, Doris Schmidt, Nadja Ellinger, Yuri Tolkach, Dimo Dietrich, Glen Kristiansen, Stefan C Müller
INTRODUCTION: Mitochondrial dysfunction is common in cancer, and the mitochondrial electron transport chain is often affected in carcinogenesis. So far, little is known about the expression of the mitochondrial complex I (NADH:ubiquinone oxidoreductase) subunits in clear-cell renal-cell carcinoma (ccRCC). MATERIALS AND METHODS: An expression profile of the mitochondrial complex I subunits was determined using the NextBio database. Subsequently, the expression of selected subunits was experimentally validated on mRNA (quantitative real-time polymerase chain reaction) and protein (Western blot analysis, immunohistochemistry) level...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28057415/comprehensive-genomic-analysis-of-metastatic-mucinous-urethral-adenocarcinoma-guides-precision-oncology-treatment-targetable-egfr-amplification-leading-to-successful-treatment-with-erlotinib
#15
Alan H Bryce, Mitesh J Borad, Jan B Egan, Rachel M Condjella, Winnie S Liang, Rafael Fonseca, Ann E McCullough, Katherine S Hunt, Nicole R Ritacca, Michael T Barrett, Maitray D Patel, Scott W Young, Alvin C Silva, Thai H Ho, Thorvardur R Halfdanarson, Melissa L Stanton, John Cheville, Scott Swanson, Daniel E Schneider, Robert R McWilliams, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D Mastrian, Daniel D Von Hoff, David W Craig, A Keith Stewart, John D Carpten
No abstract text is available yet for this article.
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28024951/role-of-molecular-profiling-in-diagnosis-of-papillary-renal-cell-cancer-presenting-as-cancer-of-unknown-primary-site
#16
Misako Nagasaka, Geetika Kukreja, Eman Abdulfatah, Ulka Vaishampayan, Ammar Sukari
No abstract text is available yet for this article.
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28024950/detection-and-clinical-significance-of-circulating-tumor-cells-in-patients-undergoing-radical-cystectomy-for-urothelial-bladder-cancer
#17
Vincenzo Pagliarulo, Patrizia Ancona, Tommasangelo Petitti, Annamaria Salerno, Rossana Spadavecchia, Savino Di Stasi, Luigi Cormio, Buscarini Maurizio, Giuseppe Carrieri, Pasquale Ditonno
INTRODUCTION: Estimation of prognosis is patients undergoing radical cystectomy is often unreliable, as occult disease remains undetected by conventional diagnostic tools. The purpose of this study was to evaluate the feasibility and the clinical significance of a polymerase chain reaction assay to detect cytokeratin 7 (CK7) mRNA expression in peripheral blood cells of patients undergoing radical cystectomy for clinically nonmetastatic bladder cancer. PATIENTS AND METHODS: From 2005 to 2009, 59 patients undergoing radical cystectomy and pelvic lymph node dissection were prospectively investigated...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28024949/acute-myeloid-leukemia-after-radium-223-therapy-case-report
#18
Andreas Varkaris, Krishna Gunturu, Tarun Kewalramani, Christopher Tretter
No abstract text is available yet for this article.
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28007367/exercise-decreases-and-smoking-increases-bladder-cancer-mortality
#19
Michael A Liss, Martha White, Loki Natarajan, J Kellogg Parsons
BACKGROUND: The aim of this study was to investigate modifiable lifestyle factors of smoking, exercise, and obesity with bladder cancer mortality. PATIENTS AND METHODS: We used mortality-linked data from the National Health Information Survey from 1998 through 2006. The primary outcome was bladder cancer-specific mortality. The primary exposures were self-reported smoking status (never- vs. former vs. current smoker), self-reported exercise (dichotomized as "did no exercise" vs...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28040424/prognostic-effect-of-carcinoma-in-situ-in-muscle-invasive-urothelial-carcinoma-patients-receiving-neoadjuvant-chemotherapy
#20
Derek E Thomas, Hristos Z Kaimakliotis, Kevin R Rice, Jose A Pereira, Paul Johnston, Marietta L Moore, Angela Reed, Dylan M Cregar, Cindy Franklin, Rhoda L Loman, Michael O Koch, Richard Bihrle, Richard S Foster, Timothy A Masterson, Thomas A Gardner, Chandru P Sundaram, Charles R Powell, Stephen D W Beck, David J Grignon, Liang Cheng, Costantine Albany, Noah M Hahn
BACKGROUND: Carcinoma in situ (CIS) is a poor prognostic finding in urothelial carcinoma. However, its significance in muscle-invasive urothelial carcinoma (MIUC) treated with neoadjuvant chemotherapy (NAC) is uncertain. We assessed the effect of CIS found in pretreatment transurethral resection of bladder tumor (TURBT) biopsies on the pathologic and clinical outcomes. MATERIALS AND METHODS: Subjects with MIUC treated with NAC before cystectomy were identified. The pathologic complete response (pCR) rates stratified by TURBT CIS status were compared...
November 30, 2016: Clinical Genitourinary Cancer
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