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Clinical Genitourinary Cancer

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https://www.readbyqxmd.com/read/27894777/efficacy-of-long-acting-octreotide-on-reducing-mucus-production-in-patients-with-ileal-neobladder
#1
Mohammad Hatef Khorrami, Amir Javid, Mohammad Hossein Izadpanahi, Farshid Alizadeh, Mahtab Zargham, Farbod Khorrami
PURPOSE: To evaluate the efficacy of long-acting-release octreotide (trade name Sandostatin) on decreasing mucus secretion, thus reducing catheter obstruction after radical cystectomy and orthotopic reconstruction. PATIENTS AND METHODS: In this double-blind, placebo-controlled study, we treated 73 cases of radical cystectomy between the years 2008 and 2014; 65 were deemed eligible for the study. Cases were randomly divided into 2 groups. Group A (n = 32) received 2 doses of 20 mg intramuscular long-acting-release octreotide 4 weeks before and on the day of surgery, while group B (n = 33) received placebo...
November 4, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27876505/squamous-cell-carcinoma-of-the-bladder-a-seer-database-analysis
#2
Omar Abdel-Rahman
BACKGROUND: Scarce evidence exists regarding the management of squamous cell carcinoma (SCC) of the bladder. This study assessed the epidemiologic and treatment trends of SCC of the bladder. MATERIALS AND METHODS: Cases of SCC of the bladder, diagnosed from 1973 to 2013, were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The incidence of SCC of the bladder with respect to time was assessed using the SEER United States population dataset...
October 28, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27865685/mixed-epithelial-and-stromal-tumor-of-the-kidney-two-case-reports-of-a-rare-benign-kidney-tumor
#3
Mustafa Ozan Horsanali, Yuksel Yilmaz, Kutan Ozer, Osman Kose, Fulya Cakalagaoglu, Demet Etit
No abstract text is available yet for this article.
October 28, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27890446/efficacy-of-therapies-after-galeterone-in-patients-with-castration-resistant-prostate-cancer
#4
Rana R McKay, Lillian Werner, Matthew Fiorillo, Jennifer Roberts, Elisabeth I Heath, Glenn J Bubley, Robert Bruce Montgomery, Mary-Ellen Taplin
BACKGROUND: Galeterone is a multi-targeted agent with activity as a CYP17 inhibitor, androgen receptor antagonist, and also causes androgen receptor degradation. It has shown meaningful anti-tumor activity with a well-tolerated safety profile in patients with castration-resistant prostate cancer (CRPC) in phase I and II studies; however, the efficacy of currently approved CRPC therapies after treatment with galeterone is unknown. In this study, we evaluate prostate specific antigen (PSA) response of non-protocol therapies following galeterone in a subset of patients treated on the Androgen Receptor Modulation Optimized for Response (ARMOR) 2 study...
October 27, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27863831/therapy-of-treatment-related-hypertension-in-metastatic-renal-cell-cancer-patients-receiving-sunitinib
#5
Philipp Ivanyi, Gernot Beutel, Nicole Drewes, Jens Pirr, Jan T Kielstein, Michael Morgan, Arnold Ganser, Viktor Grünwald
INTRODUCTION: Treatment-related hypertension (tHTN) is frequent during sunitinib treatment. However, data on risk factors and treatment of tHTN remain scarce. PATIENTS AND METHODS: Patients with metastatic renal-cell carcinoma treated with sunitinib from June 2004 to December 2011 were included. Medical records were retrospectively analyzed for tHTN risk factors and antihypertensive treatments (AHT). Descriptive statistics, Cox regression, and competitive risk models were applied...
October 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27842896/kinesin-family-member-11-mrna-expression-predicts-prostate-cancer-aggressiveness
#6
Xuan-Mei Piao, Young Joon Byun, Pildu Jeong, Yun-Sok Ha, Eun Sang Yoo, Seok Joong Yun, Wun-Jae Kim
BACKGROUND: KIF11 (kinesin family member 11), a molecular motor protein, is essential to mitosis and cell cycle progression. Inhibitors of KIF11 have been developed as chemotherapeutic agents for the treatment of various cancers. Regarding prostate cancer (PCa), clinical trials using KIF11 inhibitors for the treatment of castration-resistant PCa have been initiated. We hypothesized that a relationship might exist between KIF11 expression and PCa. To investigate the functional activities and clinical usefulness of KIF11 in PCa, we used quantitative real-time reverse transcriptase polymerase chain reaction to monitor the KIF11 expression patterns...
October 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27876504/disease-and-treatment-characteristics-of-men-diagnosed-with-metastatic-hormone-sensitive-prostate-cancer-in-real-life-analysis-from-a-commercial-claims-database
#7
Thomas W Flaig, Ravi C Potluri, Yvette Ng, Mary B Todd, Maneesha Mehra, Celestia S Higano
BACKGROUND: Our understanding of the clinical characteristics and treatment patterns of men who present with newly diagnosed metastatic (M1) hormone-sensitive prostate cancer is based mainly on clinical trial data. We sought to characterize the M1 population seen in routine clinical practice using a commercial claims database. PATIENTS AND METHODS: A US claims (2000-2013) database was used to identify patients with an index diagnosis of prostate cancer. M1 patients were identified by "International Classification of Diseases, 9th revision, Clinical Modification" diagnosis codes of metastasis to bone, viscera, distant lymph node, and unspecified sites within 90 days of the prostate cancer diagnosis...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27856204/are-dynamic-contrast-enhanced-images-necessary-for-prostate-cancer-detection-on-multiparametric-magnetic-resonance-imaging
#8
Thaís Caldara Mussi, Tatiana Martins, Rodrigo Gobbo Garcia, Renee Zon Filippi, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
BACKGROUND: To compare the results of magnetic resonance imaging (MRI) with and without contrast-enhanced sequences for the detection of clinically significant prostate cancer. The value of contrast in the MRI protocol for the detection of prostate tumors has been discussed in previous studies. MATERIALS AND METHODS: We performed an institutional review board-approved, retrospective study of patients who had undergone prostate MRI followed by fusion biopsy during a 16-month period...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27839780/prostate-cancer-in-patients-with-high-prostate-specific-antigen-levels-but-otherwise-very-low-risk-disease-behaves-like-prostate-cancer-in-high-risk-patients
#9
Matthew M Gestaut, Jessica E Pruszynski, Gregory P Swanson
INTRODUCTION: Rarely, patients with prostate cancer present with prostate-specific antigen (PSA) scores > 20 ng/mL but with otherwise very-low-risk disease. Oncologists have debated whether the malignancies in these patients behave more comparably to low-risk or high-risk disease. Our objective was to elucidate the behavior of these malignancies. MATERIALS AND METHODS: A retrospective review was conducted of prostate cancer patients treated with radiation from 2000 to 2013...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27793611/intraoperative-molecular-imaging-for-post-chemotherapy-robot-assisted-laparoscopic-resection-of-seminoma-metastasis-a-case-report
#10
Leilei Xia, Ollin G Venegas, Jarrod D Predina, Sunil Singhal, Thomas J Guzzo
No abstract text is available yet for this article.
September 23, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27765612/preoperative-albumin-is-predictive-of-early-postoperative-morbidity-and-mortality-in-common-urologic-oncologic-surgeries
#11
Ronald J Caras, Michael B Lustik, Sean Q Kern, Leah P McMann, Joseph R Sterbis
INTRODUCTION: Multiple studies have linked preoperative nutrition status to postoperative outcomes. This relationship has been little studied in urology. We used a standardized, national, risk-adjusted surgical database to evaluate 30-day outcomes of patients undergoing common urologic oncologic procedures as they related to preoperative albumin. METHODS: The American College of Surgeons National Surgical Quality Improvement Program is a risk-adjusted dataset analyzing preoperative risk factors, demographics, and 30-day outcomes...
September 23, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27789182/current-role-of-radiotherapy-for-renal-cell-carcinoma-review
#12
REVIEW
Natalia Dengina, Ilya Tsimafeyeu, Timur Mitin
Surgery is the standard of care for patients with renal-cell carcinoma (RCC). Radiotherapy (RT) can decrease the risk of local recurrence after surgery and can lead to excellent outcomes in patients unfit for surgery. We reviewed clinical experience with various forms of RT, including conventional fractionated RT and intraoperative radiotherapy (IORT) as adjunct to surgery, hypofractionated high-dose stereotactic body radiotherapy (SBRT), and particle therapy in unresectable RCC. We discuss future directions for using RT in the treatment of RCC...
September 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27765613/the-use-of-neoadjuvant-chemotherapy-in-patients-with-urothelial-carcinoma-of-the-bladder-current-practice-among-clinicians
#13
Thomas Martini, Christian Gilfrich, Roman Mayr, Maximilian Burger, Armin Pycha, Atiqullah Aziz, Michael Gierth, Christian G Stief, Stefan C Müller, Florian Wagenlehner, Jan Roigas, Oliver W Hakenberg, Florian Roghmann, Philipp Nuhn, Manfred Wirth, Vladimir Novotny, Boris Hadaschik, Marc-Oliver Grimm, Paul Schramek, Axel Haferkamp, Daniela Colleselli, Birgit Kloss, Edwin Herrmann, Margit Fisch, Matthias May, Christian Bolenz
INTRODUCTION: Guidelines recommend neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in patients with urothelial carcinoma of the bladder in clinical stages T2-T4a, cN0M0. We examined the frequency and current practice of NAC and sought to identify predictors for the use of NAC in a prospective contemporary cohort. MATERIALS AND METHODS: We analyzed prospective data from 679 patients in the PROMETRICS (PROspective MulticEnTer RadIcal Cystectomy Series 2011) database...
September 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27751686/correlation-of-psma-targeted-18-f-dcfpyl-pet-ct-findings-with-immunohistochemical-and-genomic-data-in-a-patient-with-metastatic-neuroendocrine-prostate-cancer
#14
Jeffrey J Tosoian, Michael A Gorin, Steven P Rowe, Darian Andreas, Zsolt Szabo, Kenneth J Pienta, Martin G Pomper, Tamara L Lotan, Ashley E Ross
No abstract text is available yet for this article.
September 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27726949/exceptional-duration-of-radium-223-in-prostate-cancer-with-a-brca2-mutation
#15
Allie E Steinberger, Patrick Cotogno, Elisa M Ledet, Brian Lewis, Oliver Sartor
No abstract text is available yet for this article.
September 17, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27789181/prostate-cancer-patients-with-unmanaged-diabetes-or-receiving-insulin-experience-inferior-outcomes-and-toxicities-after-treatment-with-radiation-therapy
#16
Nicholas G Zaorsky, Talha Shaikh, Karen Ruth, Pankaj Sharda, Shelly B Hayes, Mark L Sobczak, Mark A Hallman, Marc C Smaldone, David Y T Chen, Eric M Horwitz
BACKGROUND: The purpose of the study was to determine the effect of type 2 diabetes mellitus (T2DM) on outcomes and toxicities among men with localized prostate cancer receiving definitive radiation therapy. PATIENTS AND METHODS: We performed a retrospective review of 3217 patients, from 1998 to 2013, subdivided into 5 subgroups: (I) no T2DM; (II) T2DM receiving oral antihyperglycemic agent that contains metformin, no insulin; (III) T2DM receiving nonmetformin oral agent alone, no insulin; (IV) T2DM receiving any insulin; and (V) T2DM not receiving medication...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27771244/a-study-of-combination-bicalutamide-and-raloxifene-for-patients-with-castration-resistant-prostate-cancer
#17
Thai H Ho, Rafael Nunez-Nateras, Yue-Xian Hou, Alan H Bryce, Donald W Northfelt, Amylou C Dueck, Bryan Wong, Melissa L Stanton, Richard W Joseph, Erik P Castle
BACKGROUND: Prostate tissue expresses 2 estrogen receptor (ER) isoforms, ER-α and ER-β, and estrogen-based therapies have shown activity in preclinical studies. Raloxifene, a selective ER modulator, has inhibited the growth of prostate cancer xenograft models and was tested in a phase II trial of castration-resistant prostate cancer (CRPC), with some patients achieving stable disease. However, no studies have examined the safety of the combination of bicalutamide plus raloxifene for CRPC...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27720164/survival-of-patients-with-advanced-or-metastatic-renal-cell-carcinoma-in-routine-practice-differs-from-that-in-clinical-trials-analyses-from-the-german-clinical-rcc-registry
#18
Norbert Marschner, Michael Staehler, Lothar Müller, Arnd Nusch, Johanna Harde, Michaela Koska, Martina Jänicke, Peter J Goebell
INTRODUCTION: Because "real-life" patients often do not meet the strict eligibility criteria of clinical trials, we assessed the trial eligibility of patients with advanced or metastatic renal cell carcinoma (mRCC) in routine practice and compared the survival of "trial-ineligible" and potentially "trial-eligible" patients. PATIENTS AND METHODS: The present prospective, multicenter German cohort study is recruiting patients from 110 oncology/urology outpatient centers and hospitals at initiation of systemic first-line treatment...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27692811/clinical-impact-of-the-number-of-treatment-cycles-in-first-line-docetaxel-for-patients-with-metastatic-castration-resistant-prostate-cancer
#19
Per Kongsted, Inge Marie Svane, Henriette Lindberg, Lisa Sengeløv
BACKGROUND: We investigated the impact of the number of docetaxel cycles administered in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with first-line chemotherapy. PATIENTS AND METHODS: Charts from 421 consecutive patients who initiated standard treatment with docetaxel-based chemotherapy (75 mg/m(2) every 3 weeks) between 2007 and 2013 were reviewed. Patients who received < 6 cycles of docetaxel were excluded from the analysis...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27692810/effect-of-bleomycin-administration-on-the-development-of-pulmonary-toxicity-in-patients-with-metastatic-germ-cell-tumors-receiving-first-line-chemotherapy-a-meta-analysis-of-randomized-studies
#20
Andrea Necchi, Rosalba Miceli, Karima Oualla, Guru Sonpavde, Patrizia Giannatempo, Daniele Raggi, Nicola Nicolai, Roberto Boffi, Alessandra Busia, Luigi Mariani, Roberto Salvioni
BACKGROUND: Limited information is available about the effect of bleomycin administration on the development of pulmonary toxicity in metastatic germ cell tumors (GCT). PATIENTS AND METHODS: A literature search was conducted to identify randomized trials of first-line chemotherapy for GCT. We conducted univariate and multivariate analyses using random effects models to evaluate the predictive role of bleomycin administration in the development of all Grade and Grade 3 to 4 (G3-4) pulmonary toxicity...
September 8, 2016: Clinical Genitourinary Cancer
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