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Clinical Genitourinary Cancer

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https://www.readbyqxmd.com/read/29158079/bone-metastases-as-the-only-metastatic-site-in-patients-with-urothelial-carcinoma-focus-on-a-special-patient-population
#1
Andrea Necchi, Gregory R Pond, Sumanta K Pal, Neeraj Agarwal, Daniel W Bowles, Elizabeth R Plimack, Evan Y Yu, Sylvain Ladoire, Jack Baniel, Simon Crabb, Gunter Niegisch, Sandy Srinivas, Dominik R Berthold, Jonathan E Rosenberg, Thomas Powles, Aristotelis Bamias, Lauren C Harshman, Joaquim Bellmunt, Matthew D Galsky
BACKGROUND: Patients with exclusive bone metastatic spread from urothelial carcinoma (UC) throughout their disease course represent a rare subgroup with unique clinical features. These patients deserved special consideration in a retrospective multicenter study. PATIENTS AND METHODS: Analyses were made from a pool of 1911 patients with a diagnosis of metastatic UC, from 23 centers. Baseline characteristics, access to treatment, and outcomes were analyzed according to metastatic spread...
November 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29137877/immune-analysis-of-radium-223-in-patients-with-metastatic-prostate-cancer
#2
Joseph W Kim, Min Sun Shin, Youna Kang, Insoo Kang, Daniel P Petrylak
BACKGROUND: Radium223 (Ra223) delivers high-energy radiation to osteoblastic metastasis of prostate cancer, resulting in irreparable double-stranded DNA damage. The effects of Ra223 on CD8+ T cell subsets in patients with prostate cancer is unknown. PATIENTS AND METHODS: Fifteen men with metastatic prostate cancer with clinical indication for Ra223 without any autoimmune or immune deficiency conditions were enrolled. Patients received a course of Ra223 50 kBq/kg...
October 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29154041/patient-characteristics-treatment-patterns-and-prognostic-factors-in-squamous-cell-bladder-cancer
#3
Haris Zahoor, Paul Elson, Andrew Stephenson, Georges-Pascal Haber, Jihad Kaouk, Amr Fergany, Byron Lee, Vadim Koshkin, Moshe Ornstein, Timothy Gilligan, Jorge A Garcia, Brian Rini, Petros Grivas
BACKGROUND: Squamous cell carcinoma (SCC) is an uncommon histologic subtype of bladder cancer with limited data on treatment patterns, outcomes, and prognostic factors. "Real world" information might inform decision-making, prognostic estimates, and clinical trial designs. PATIENTS AND METHODS: A retrospective review of patients with tissue-confirmed bladder SCC treated at Cleveland Clinic from 2007 to 2016 was performed. Data on patient characteristics, treatment patterns, and clinical follow-up were extracted...
October 17, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113770/pathologic-predictors-of-survival-during-lymph-node-dissection-for-metastatic-renal-cell-carcinoma-results-from-a-multicenter-collaboration
#4
Juan Chipollini, E Jason Abel, Charles C Peyton, David C Boulware, Jose A Karam, Vitaly Margulis, Viraj A Master, Kamran Zargar-Shoshtari, Surena F Matin, Wade J Sexton, Jay D Raman, Christopher G Wood, Philippe E Spiess
PURPOSE: To determine the therapeutic value of lymph node dissection (LND) during cytoreductive nephrectomy (CN) and assess predictors of cancer-specific survival (CSS) in metastatic renal-cell carcinoma. PATIENTS AND METHODS: We identified 293 consecutive patients treated with CN at 4 academic institutions from March 2000 to May 2015. LND was performed in 187 patients (63.8%). CSS was estimated by the Kaplan-Meier method for the entire cohort and for a propensity score-matched cohort...
October 17, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113772/oncologic-outcomes-of-definitive-treatments-for-low-and-intermediate-risk-prostate-cancer-after-a-period-of-active-surveillance
#5
Michael J Whalen, Jamie S Pak, Danny Lascano, David Ahlborn, Justin T Matulay, James M McKiernan, Mitchell C Benson, Sven Wenske
BACKGROUND: To compare oncologic outcomes of different definitive treatment (DT) modalities in a cohort of patients with prostate cancer (PCa) after active surveillance (AS). METHODS: We identified 237 patients with National Comprehensive Cancer Network (NCCN) low- and intermediate-risk prostate cancer diagnosed from 1990 to 2012 who did not undergo immediate DT within 12 months of diagnosis (ie, AS patients as well as watchful waiting and those refusing DT). Charts were examined for clinical/pathologic data and type of DT: surgery (RP), radiation including brachytherapy (XRT), cryotherapy, and androgen deprivation therapy monotherapy (ADT)...
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113771/rate-and-extent-of-pelvic-lymph-node-dissection-in-the-us-prostate-cancer-patients-treated-with-radical-prostatectomy
#6
Luigi Nocera, Akshay Sood, Deepansh Dalela, Philipp Gild, Craig G Rogers, James O Peabody, Francesco Montorsi, Mani Menon, Alberto Briganti, Firas Abdollah
PURPOSE: To evaluate the utilization of pelvic lymph node dissection (PLND) and its extent in contemporary US patients, and to correlate it to the detection of pN1 disease. PATIENTS AND METHODS: A total of 328,710 individuals who received radical prostatectomy between the years 2004 and 2013 were identified within the National Cancer Data Base. The Cochran-Armitage test was used to assess the statistical significance of temporal trends. Logistic regression analysis tested the relationship between the number of lymph nodes removed (LNR) and pN1 rate...
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113769/advanced-scrotal-extramammary-paget-s-disease-treated-with-apatinib-a-case-report
#7
Yun-Ni Zhang, Ye Chen, Feng Gao, Ni Chen, Ji-Yan Liu
No abstract text is available yet for this article.
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113768/female-urethra-adenocarcinoma
#8
REVIEW
Lucio Dell'Atti, Andrea Benedetto Galosi
Female urethra adenocarcinoma (FUA) is a rare aggressive tumor that occurs in Skene ducts and glands. It is associated with a relatively poor prognosis. The aim of this review was to evaluate FUA in terms of epidemiology, risk factors, diagnosis, natural history of disease, modalities of treatment, and outcomes. These tumors are usually large masses, which typically spread through the lymphatic system. Patients present with vague symptoms similar to urinary tract infections. Cystourethroscopy permits visualization of the urethral tumor and allows biopsies to be performed to remove samples for histologic examination...
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29104087/long-term-survival-of-good-risk-germ-cell-tumor-patients-after-postchemotherapy-retroperitoneal-lymph-node-dissection-a-comparison-of-bep%C3%A2-%C3%A3-3-vs-ep%C3%A2-%C3%A3-4-and-treating-institution
#9
Clint Cary, Joseph M Jacob, Costantine Albany, Timothy A Masterson, Nasser H Hanna, Lawrence H Einhorn, Richard S Foster
BACKGROUND: Patients with International Germ Cell Cancer Collaborative Group (IGCCCG) good-risk testicular cancer might receive either 4 cycles of etoposide and cisplatin (EP × 4) or 3 cycles of bleomycin, etoposide, and cisplatin (BEP × 3). We sought to examine differences in survival after retroperitoneal lymph node dissection (PC-RPLND) between patients who received EP × 4 compared with BEP × 3. PATIENTS AND METHODS: The Indiana University Testis Cancer database was queried to identify IGCCCG good-risk PC-RPLND patients who received either EP × 4 or BEP × 3 induction chemotherapy...
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29111177/association-of-androgen-receptor-expression-on-tumor-cells-and-pd-l1-expression-in-muscle-invasive-and-metastatic-urothelial-carcinoma-insights-for-clinical-research
#10
Andrea Necchi, Salvatore Lo Vullo, Patrizia Giannatempo, Daniele Raggi, Federica Perrone, Nicola Nicolai, Mario Catanzaro, Davide Biasoni, Tullio Torelli, Luigi Piva, Silvia Stagni, Roberto Salvioni, Luigi Mariani, Maurizio Colecchia
BACKGROUND: Limited information is available regarding the use of androgen receptor (AR) immunohistochemical expression in muscle-invasive or metastatic urothelial carcinoma. We aimed to evaluate the frequency of AR expression by tumor cells (TC), its prognostic role, and its relationship with programmed cell-death ligand 1 (PD-L1) expression in these patients. PATIENTS AND METHODS: From September 2015 to January 2017, we collected tissue from patients who received platinum-based chemotherapy at our center...
October 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29111176/fluorine-18-prostate-specific-membrane-antigen-1007-positron-emission-tomography-computed-tomography-and-multiparametric-magnetic-resonance-imaging-in-diagnostics-of-local-recurrence-in-a-prostate-cancer-patient-after-recent-radical-prostatectomy
#11
Kiryl Paddubny, Martin T Freitag, Clemens Kratochwil, Stefan Koerber, Jan P Radtke, Ruslan Sakovich, Klaus Kopka, Frederik L Giesel
No abstract text is available yet for this article.
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29111175/recognizing-symptom-burden-in-advanced-prostate-cancer-a-global-patient-and-caregiver-survey
#12
Lawrence Drudge-Coates, William K Oh, Bertrand Tombal, Anthony Delacruz, Brian Tomlinson, Aimee Vella Ripley, Ken Mastris, Joe M O'Sullivan, Neal D Shore
BACKGROUND: Bone metastases in men with prostate cancer are often initially asymptomatic, resulting in delayed identification, diagnosis, and appropriate treatment. To assess how patients with advanced prostate cancer (aPC) communicate symptoms to health care providers, an international patient survey was conducted. METHODS: An online and phone survey was conducted by Harris Poll in 11 countries (Brazil, France, Germany, Japan, Italy, Netherlands, Singapore, Spain, Taiwan, United Kingdom, United States) from February 12 to October 27, 2015, in men with aPC (ie, those who reported as having PC beyond the prostate [metastatic]) and their caregivers...
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29079166/benefits-of-urologic-dermatologic-consultations-for-the-diagnosis-of-cutaneous-penile-lesions-a%C3%A2-prospective-study
#13
Edouard Fortier, Arnaud Cerruti, Christian Le Clec'h, Abdel-Rahmène Azzouzi, Pierre Bigot
INTRODUCTION: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions. MATERIALS AND METHODS: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. We collected the demographic data, clinical examination findings, and the proposed diagnosis and treatment for every patient...
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29126815/analysis-of-suicide-risk-in-patients-with-penile-cancer-and-review-of-the-literature
#14
REVIEW
William G Simpson, Zachary Klaassen, Rita P Jen, William M Hughes, Durwood E Neal, Martha K Terris
The treatment for penile cancer has been shown to cause harmful psychiatric symptoms as well as have detrimental effects on well-being. In the past several years, alternatives to total or partial penectomy have emerged, such as chemotherapy, radiation, penile sparing, and laser ablation therapies. A more specific breakdown for penile cancer is in order as the therapy has the potential for life changing surgery. We examined the Surveillance, Epidemiology, and End Results (SEER) database (1973-2013), comprising 28% of the United States population...
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29074284/retroperitoneal-robot-assisted-versus-open-partial-nephrectomy-for-ct1-renal-tumors-a-matched-pair-comparison-of-perioperative-and-early-oncological-outcomes
#15
Marco Borghesi, Riccardo Schiavina, Francesco Chessa, Lorenzo Bianchi, Gaetano La Manna, Angelo Porreca, Eugenio Brunocilla
BACKGROUND: The objective of this study was to compare perioperative and early oncological outcomes of a matched cohort of patients who underwent retroperitoneal robot-assisted partial nephrectomy (RP-RAPN) and open partial nephrectomy (OPN) for clinically localized renal tumors. PATIENTS AND METHODS: We performed a retrospective analysis of patients who underwent RP-RAPN and OPN treated at 2 referral centers from January 2011 to December 2015. We focused on the following postoperative outcomes: warm ischemia time (WIT), operative time, blood loss, intra- and postoperative complications, estimated glomerular filtration rate (eGFR), hospital stay, and positive surgical margins...
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29066074/metastatic-adenocarcinoma-of-the-epididymis-a-case-report-and-brief-literature-review
#16
Laura Graham, Lawrence D True, Michael T Schweizer
No abstract text is available yet for this article.
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29113767/renal-functional-outcome-of-partial-nephrectomy-for-complex-r-e-n-a-l-score-tumors-with-or-without-neoadjuvant-sunitinib-a-multicenter-analysis
#17
Michelle L McDonald, Brian R Lane, Juan Jimenez, Hak J Lee, Kendrick Yim, Ahmet Bindayi, Zachary A Hamilton, Charles A Field, Aaron S Bloch, Sumi Dey, Sabrina Noyes, Rana McKay, Frederick Millard, Brian I Rini, Steven C Campbell, Ithaar H Derweesh
BACKGROUND: Sunitinib might optimize the feasibility of partial nephrectomy (PN) for complex renal tumors with imperative indications. We compared the renal functional outcomes of patients with complex renal masses who had undergone sunitinib before PN with those of patients who had not required neoadjuvant sunitinib before PN. PATIENTS AND METHODS: We performed a multicenter retrospective analysis of patients with renal cell carcinoma who had undergone PN for a complex renal mass (R...
September 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29066073/factors-influencing-overall-survival-for-patients-with-metastatic-clear-cell-renal-cell-carcinoma-in-daily-practice
#18
Antoine Thiery-Vuillemin, Tiphaine Cholley, Fabien Calcagno, Marion Hugues, Tristan Maurina, Samuel Limat, Thierry Nguyen Tan Hon, Hamadi Almotlak, Guillaume Mouillet, Virginie Nerich
PURPOSE: To describe factors associated with overall survival (OS) among patients with metastatic clear-cell renal-cell carcinoma (mccRCC) in regard to evolution of systemic therapies. PATIENTS AND METHODS: Two hundred twenty-four consecutive patients with histologically confirmed mccRCC who received targeted therapy on first-line treatment between January 2007 and March 2015 were included. The primary end point was OS for metastatic first-line or second-line treatment...
September 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29074285/local-salvage-treatment-of-post-brachytherapy-recurrent-prostate-cancer-via-theranostic-application-of-psma-labeled-lutetium-177
#19
Mehmet Onur Demirkol, Murat Can Kiremit, Omer Acar, Okan Falay, Burcu Ucar, Tarik Esen
No abstract text is available yet for this article.
September 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29051056/recovery-of-serum-testosterone-levels-and-sexual-function-in-patients-treated-with-short-term-luteinizing-hormone-releasing-hormone-antagonist-as-a-neoadjuvant-therapy-before-external-radiotherapy-for-intermediate-risk-prostate-cancer-preliminary-prospective
#20
Takahiro Inoue, Takashi Mizowaki, Daijiro Kabata, Ayumi Shintani, Naoki Terada, Toshinari Yamasaki, Hiromitsu Negoro, Takashi Kobayashi, Kiyonao Nakamura, Haruo Inokuchi, Osamu Ogawa
INTRODUCTION: External beam radiation therapy (EBRT) with short-term androgen deprivation therapy is the standard of care for intermediate-risk prostate cancer patients. However, no study to date has evaluated the hormonal kinetics or sexual and hormonal function recovery after cessation of short-term luteinizing hormone (LH)-releasing hormone (LHRH) antagonist treatment. PATIENTS AND METHODS: Ten intermediate-risk prostate cancer patients (mean age, 69.9 years) were included...
September 23, 2017: Clinical Genitourinary Cancer
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