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Clinical Genitourinary Cancer

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https://www.readbyqxmd.com/read/28209454/treatment-of-carcinoma-in-situ-of-the-glans-penis-with-topical-imiquimod-followed-by-carbon-dioxide-laser-excision
#1
Tullio Torelli, Mario A Catanzaro, Nicola Nicolai, Patrizia Giannatempo, Andrea Necchi, Daniele Raggi, Biagio Paolini, Maurizio Colecchia, Luigi Piva, Davide Biasoni, Silvia Stagni, Antonio Tesone, Roberto Salvioni
BACKGROUND: Different approaches have been described in published studies for carcinoma in situ (CIS) of the glans penis (erythroplasia of Queyrat), including topical chemotherapy or immunotherapy and laser or surgical excision. We evaluated the efficacy of topical imiquimod (IQ) followed by carbon dioxide laser ablation of the lesion. PATIENTS AND METHODS: From 2010 to 2015, 10 patients affected by CIS of the glans were treated by IQ, followed by carbon dioxide laser ablation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28190704/high-risk-prostate-cancer-and-radiotherapy-the-past-and-the-future-a-benchmark-for-a-new-mixed-beam-radiotherapy-approach
#2
Giulia Marvaso, Barbara A Jereczek-Fossa, Giulia Riva, Camilla Bassi, Cristiana Fodor, Delia Ciardo, Raffaella Cambria, Floriana Pansini, Dario Zerini, Paolo De Marco, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia
BACKGROUND: The prognosis for patients with high-risk prostate cancer is poor. No consensus exists on the most effective treatment. The aim of this retrospective study was to identify the biochemical progression-free survival and the toxicity profile of patients with localized high-risk prostate cancer treated with external beam radiation therapy. These results will constitute a benchmark for a prospective "mixed beam" trial: a boost with carbon ions followed by a pelvic photon intensity-modulated radiotherapy (NCT02672449 [clinicaltrials...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28188049/gene-polymorphism-related-individual-and-interracial-differences-in-the-outcomes-of-androgen-deprivation-therapy-for-prostate-cancer
#3
REVIEW
Naohiro Fujimoto, Masaki Shiota, Ikko Tomisaki, Akinori Minato
Among patients with prostate cancer, the prognosis after androgen deprivation therapy differs significantly among individuals and among races; however, the reasons underlying these differences are poorly understood. Several single nucleotide polymorphisms in genes associated with prostate cancer progression or castration resistance might serve as the host factor that influences prognosis and, thus, accounts for these individual and racial gaps in treatment outcomes. Accordingly, single nucleotide polymorphisms associated with treatment outcomes could be used as predictive and/or prognostic biomarkers for patient stratification and to identify personalized treatment and follow-up protocols...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28188047/pretreatment-serum-prealbumin-as-an-independent-prognostic-indicator-in-patients-with-metastatic-renal-cell-carcinoma-using-tyrosine-kinase-inhibitors-as-first-line-target-therapy
#4
Wen Cai, Wen Kong, Baijun Dong, Jin Zhang, Yonghui Chen, Wei Xue, Yiran Huang, Lixin Zhou, Jiwei Huang
BACKGROUND: Although serum prealbumin is a sensitive marker to assess malnutrition, its prognostic impact in patients with metastatic renal cell carcinoma (mRCC) remains elusive. METHODS: Patients' data were retrospectively retrieved from the medical records of Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine from March 2006 to July 2015 to access overall survival (OS) and progression-free survival (PFS). The survival outcomes of patients with low pretreatment prealbumin (< 200 mg/L) and high pretreatment prealbumin (≥ 200 mg/L) were compared using a log-rank test and Cox proportional hazard regression model...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28188046/the-prognostic-role-of-circulating-tumor-cells-ctc-in-high-risk-non-muscle-invasive-bladder-cancer
#5
Gian Maria Busetto, Matteo Ferro, Francesco Del Giudice, Gabriele Antonini, Benjamin I Chung, Isabella Sperduti, Diana Giannarelli, Giuseppe Lucarelli, Marco Borghesi, Gennaro Musi, Ottavio de Cobelli, Ettore De Berardinis
INTRODUCTION: The purpose of this study was to evaluate the impact of circulating tumor cells (CTCs) as a prognostic marker in patients with high-risk non-muscle-invasive bladder cancer (NMIBC) and assess the efficacy and reliability of 2 different CTC isolation methods. MATERIALS AND METHODS: Globally, 155 patients with a pathologically confirmed diagnosis of high-risk NMIBC were included (pT1G3 with or without carcinoma in situ) and underwent transurethral resection of bladder tumor (TURB) after a blood withdrawal for CTC evaluation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28189432/risk-of-distinctive-hair-changes-associated-with-pazopanib-in-patients-with-renal-cell-carcinoma-rcc-versus-patients-without-rcc-a-comparative-systematic-review-and-meta-analysis
#6
Hesham Elhalawani, Muhammad Heiba, Omar Abdel-Rahman
OBJECTIVE: This systematic review and meta-analysis was accomplished with the purpose of evaluating the risk of encountering selected hair changes in patients with cancer receiving pazopanib. METHODS: We favored relevant prospective randomized phase II and III trials that assessed pazopanib in patients with cancer, depicting various hair-related changes, as eligible for inclusion. RESULTS: After elimination of ineligible studies, a total of 11 clinical trials were regarded as eligible for the meta-analysis...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28174011/prognostic-role-of-neutrophil-to-lymphocyte-ratio-based-markers-during-pre-and-postadjuvant-chemotherapy-in-patients-with-advanced-urothelial-carcinoma-of-upper-urinary-tract
#7
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: The aim of the present study was to assess the prognostic significance of neutrophil-to-lymphocyte ratio (NLR)-based markers before and after adjuvant chemotherapy (ACH) in patients with urothelial carcinoma of the upper urinary tract (UTUC) undergoing radical nephroureterectomy (RNU) and ACH. MATERIALS AND METHODS: The data from 112 patients with advanced UTUC who had undergone first-line ACH after RNU from 1994 to 2012 were reviewed. After excluding 22 patients, the clinicopathologic data for 90 patients were analyzed, in particular, the NLR and derived NLR (dNLR) preoperatively and before and after ACH...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28188048/prognostic-value-of-leptin-receptor-overexpression-in-upper-tract-urothelial-carcinomas-in-taiwan
#8
Yi-Chen Lee, Wen-Jeng Wu, Hui-Hui Lin, Wei-Ming Li, Chun-Nung Huang, Wei-Chi Hsu, Lin-Li Chang, Ching-Chia Li, Hsin-Chih Yeh, Chien-Feng Li, Hung-Lung Ke
OBJECTIVES: Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathologic variables...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28185875/salvage-stereotactic-body-radiotherapy-for-isolated-lymph-node-recurrent-prostate-cancer-single-institution-series-of-94-consecutive-patients-and-124-lymph-nodes
#9
Barbara Alicja Jereczek-Fossa, Giuseppe Fanetti, Cristiana Fodor, Delia Ciardo, Luigi Santoro, Claudia Maria Francia, Matteo Muto, Alessia Surgo, Dario Zerini, Giulia Marvaso, Giorgia Timon, Paola Romanelli, Elena Rondi, Stefania Comi, Federica Cattani, Federica Golino, Stefano Mazza, Deliu Victor Matei, Matteo Ferro, Gennaro Musi, Franco Nolè, Ottavio de Cobelli, Piet Ost, Roberto Orecchia
BACKGROUND: The purpose of the study was to evaluate the prostate serum antigen (PSA) response, local control, progression-free survival (PFS), and toxicity of stereotactic body radiotherapy (SBRT) for lymph node (LN) oligorecurrent prostate cancer. PATIENTS AND METHODS: Between May 2012 and October 2015, 124 lesions were treated in 94 patients with a median dose of 24 Gy in 3 fractions. Seventy patients were treated for a single lesion and 25 for > 1 lesion...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28162943/impact-of-intra-and-postoperative-blood-transfusion-on-the-incidence-timing-and-pattern-of-disease-recurrence-after-radical%C3%A2-cystectomy
#10
Marco Moschini, Francesco Soria, Mohammad Abufaraj, Beat Foerster, David D'Andrea, Rocco Damiano, Tobias Klatte, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina, Shahrokh F Shariat
BACKGROUND: The administration of blood transfusion (BT) has been associated with a decrease in survival expectancies in patients treated with radical cystectomy (RC), as a consequence of the immunosuppressive effect mediated by BT. We sought therefore to evaluate if the usage of BT may influence the risk and pattern location of distant recurrences after RC, which may be influenced by this effect. METHODS: Data from 2 independent cohorts of consecutive patients with bladder cancer treated with RC were analyzed...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28162942/can-the-preoperative-neutrophil-to-lymphocyte-ratio-significantly-predict-the-conditional-survival-probability-in-muscle-invasive-bladder-cancer-patients-undergoing-radical-cystectomy
#11
Minyong Kang, Ulanbek J Balpukov, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
INTRODUCTION: The present study investigated the prognostic value of the preoperative neutrophil-to-lymphocyte ratio (NLR) in bladder cancer patients undergoing radical cystectomy (RC), with a focus on the conditional survival (CS) estimates over time after surgery. MATERIALS AND METHODS: We analyzed 385 bladder cancer patients who underwent RC from 1999 to 2012. The patients were classified into 2 groups according to the preoperative NLR (< 2.5 vs. ≥ 2.5)...
January 9, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28139446/patient-frailty-and-discharge-disposition-following-radical-cystectomy
#12
Jeffrey A Pearl, Dattatraya Patil, Christopher P Filson, Shipra Arya, Mehrdad Alemozaffar, Viraj A Master, Kenneth Ogan
BACKGROUND: Patients with bladder cancer who are treated with cystectomy are at high risk for complications and prolonged length of stay. This population tends to be of advanced age with underlying comorbidities, and thus more likely to have decreased physiologic reserve (ie, frailty). Our objective was to evaluate the relationship between frailty and discharge disposition for patients with bladder cancer treated with cystectomy. MATERIALS AND METHODS: Using data from the National Surgical Quality Improvement Program, we identified patients with bladder cancer undergoing cystectomy (2011-2014)...
January 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28139444/real-world-survival-outcomes-and-prognostic-factors-among-patients-receiving-first-targeted-therapy-for-advanced-renal-cell-carcinoma-a-seer-medicare-database-analysis
#13
Sumanta K Pal, Sameer R Ghate, Nanxin Li, Elyse Swallow, Miranda Peeples, Miriam L Zichlin, Jose Ricardo Perez, Neeraj Agarwal, Nicholas J Vogelzang
BACKGROUND: The real-world survival outcomes and prognostic factors among patients receiving first-line targeted therapy for advanced renal cell carcinoma (aRCC) are not well known. PATIENTS AND METHODS: Adult patients diagnosed with RCC and treated with first-line targeted therapy were identified from the Surveillance, Epidemiology, and End Results-Medicare database (January 1, 1993 to December 31, 2012). The patients were grouped into early (2006-2009) or late (2010-2012) targeted therapy era cohorts by the year of the first-line targeted therapy initiation...
January 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28131750/efficacy-of-eplerenone-in-the-management-of-mineralocorticoid-excess-in-men-with-metastatic-castration-resistant-prostate-cancer-treated-with-abiraterone-without-prednisone
#14
David Gill, David Gaston, Erin Bailey, Andrew Hahn, Sumati Gupta, Julia Batten, Anitha Alex, Kenneth Boucher, David Stenehjem, Neeraj Agarwal
BACKGROUND: Abiraterone acetate has been approved for metastatic castration-resistant prostate cancer (mCRPC). Coadministration with prednisone has been recommended to prevent the toxicity from secondary mineralocorticoid excess, such as hypertension, hypokalemia, and edema. However, the use of prednisone is often not desired by patients because of the potential for detrimental effects of long-term therapy with corticosteroids, especially in those with comorbidities such as diabetes or who have received previous immunotherapeutic agents...
January 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28153390/nucleolin-staining-may-aid-in-the-identification-of-circulating-prostate-cancer-cells
#15
Heather J Chalfin, James E Verdone, Emma E van der Toom, Stephanie Glavaris, Michael A Gorin, Kenneth J Pienta
INTRODUCTION: Circulating tumor cells (CTCs) have great potential as circulating biomarkers for solid malignancies. Currently available assays for CTC detection rely on epithelial markers with somewhat limited sensitivity and specificity. We found that the staining pattern of nucleolin, a common nucleolar protein in proliferative cells, separates CTCs from white blood cells (WBCs) in men with metastatic prostate cancer. PATIENTS AND METHODS: Whole peripheral blood from 3 men with metastatic prostate cancer was processed with the AccuCyte CTC system (RareCyte, Seattle, WA)...
January 4, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28089720/condyloma-acuminatum-of-urinary-bladder-in-a-male-renal-transplant-recipient-a-diagnostic-and-therapeutic-challenge
#16
Aruna Nambirajan, Abhishek Kumar Shukla, Sandeep R Mathur, Hemanth Kumar, Rajeev Kumar, Dipankar M Bhowmik, Ashok Singh, Deepali Jain, Mehar Chand Sharma, Seema Kaushal
No abstract text is available yet for this article.
January 4, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28139445/lymphoepithelioma-like-bladder-carcinoma-a-diagnostic-and-therapeutic-challenge-contribution-using-a-new-case-and-review-of-the-literature
#17
Miguel Angel Rodríguez-Cabello, Santiago Méndez-Rubio, Juan Luis Sanz-Miguelañez, Javier Saenz-Medina, Pablo Garrido-Abad, Anabel Del-Barrio-Díaz-Aldagalan, Consuelo López-Elzaurdia, Arturo Platas-Sancho
No abstract text is available yet for this article.
December 30, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28111174/a-systematic-review-and-meta-analysis-of-the-diagnostic-accuracy-of-prostate-health-index-and-4-kallikrein-panel-score-in-predicting-overall-and-high-grade-prostate-cancer
#18
REVIEW
Giorgio Ivan Russo, Federica Regis, Tommaso Castelli, Vincenzo Favilla, Salvatore Privitera, Raimondo Giardina, Sebastiano Cimino, Giuseppe Morgia
Markers for prostate cancer (PCa) have progressed over recent years. In particular, the prostate health index (PHI) and the 4-kallikrein (4K) panel have been demonstrated to improve the diagnosis of PCa. We aimed to review the diagnostic accuracy of PHI and the 4K panel for PCa detection. We performed a systematic literature search of PubMed, EMBASE, Cochrane, and Academic One File databases until July 2016. We included diagnostic accuracy studies that used PHI or 4K panel for the diagnosis of PCa or high-grade PCa...
December 30, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28190703/long-term-treatment-with-sequential-molecular-targeted-therapy-for-xp11-2-translocation-renal-cell-carcinoma-a-case-report-and-review-of-the%C3%A2-literature
#19
Katsura Kakoki, Yasuyoshi Miyata, Yasushi Mochizuki, Takahisa Iwata, Masayuki Obatake, Kuniko Abe, Takeshi Nagayasu, Hideki Sakai
No abstract text is available yet for this article.
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28131752/high-neutrophil-to-lymphocyte-ratio-as-prognostic-factor-in-patients-affected-by-upper-tract-urothelial-cancer-a-systematic-review-and%C3%A2-meta-analysis
#20
REVIEW
Michele Marchioni, Luca Cindolo, Riccardo Autorino, Giulia Primiceri, Davide Arcaniolo, Marco De Sio, Luigi Schips
Given the increasing interest in the possible role of the neutrophil-to-lymphocyte ratio (NLR) as an easily available oncologic marker for upper tract urothelial cancer (UTUC), we sought to quantify the prognostic effect of this biomarker and assess its consistency in UTUC. A systematic review of the published data was performed up to May 2016 using multiple search engines (PubMed, Ovid, and Scopus) to identify eligible comparative studies. A formal meta-analysis was performed for studies comparing patients with a high and those with a low NLR before surgical treatment of UTUC to determine whether the NLR is an independent predictor of survival...
December 29, 2016: Clinical Genitourinary Cancer
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