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Clinical Genitourinary Cancer

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https://www.readbyqxmd.com/read/28624320/prognostic-value-of-the-vhl-hif-1%C3%AE-and-vegf-signaling-pathway-and-associated-mapk-erk1-2-and-erk5-pathways-in-clear-cell-renal-cell-carcinoma-a-long-term-study
#1
Antonio S Salinas-Sánchez, Leticia Serrano-Oviedo, Syongh Y Nam-Cha, Olga Roche-Losada, Ricardo Sánchez-Prieto, José M Giménez-Bachs
BACKGROUND: The prognostic value of molecular markers in renal cell carcinoma has been investigated in several studies. Although their value is still not confirmed, various proteins are important. We describe the effect on long-term survival of the status of the von Hippel-Lindau (VHL) hypoxia-inducible factor 1-α (HIF1-α) signaling pathway as well as associated mitogen-activated protein kinase (extracellular signal-regulated kinase [ERK]1/2 and ERK5). PATIENTS AND METHODS: A prospective, longitudinal cohort study was conducted with 50 patients diagnosed with clear-cell renal cell carcinoma to analyze VHL mutations and hypermethylation as well as VHL, HIF1-α, vascular endothelial growth factor (VEGF), ERK1/2, and ERK5 protein expression...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28624319/the-efficacy-of-lenvatinib-and-everolimus-in-chromophobe-type-non-clear-cell-renal-cell-carcinoma-a-case-report-and-literature-review
#2
Candice Schwartz, Nicklas Pfanzelter, Timothy M Kuzel
No abstract text is available yet for this article.
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28606737/long-term-survival-in-a-patient-with-metastatic-ddr2-positive-adrenal-cortical-carcinoma
#3
Fadi Taza, Michal Chovanec, Noah Hahn, Costantine Albany
No abstract text is available yet for this article.
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28625691/a-case-of-locally-advanced-castration-resistant-prostate-cancer-with-remarkable-response-to-nivolumab
#4
Alina Basnet, Gaurav Khullar, Rohin Mehta, Namita Chittoria
No abstract text is available yet for this article.
May 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28606736/clinical-features-and-outcomes-of-tunica-vaginalis-mesothelioma-a-case-series-from-the-national-institutes-of-health
#5
Julie Y An, David Kim, Sally Tanakchi, Alice M Semerjian, Anish Thomas, Shawna L Boyle, Raffit Hassan, Adam R Metwalli
No abstract text is available yet for this article.
May 22, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28625690/what-have-patients-been-hearing-from-providers-since-the-2012-uspstf-recommendation-against-routine-prostate-cancer-screening
#6
Mohammad Rifat Haider, Zaina P Qureshi, Ronnie Horner, Daniela B Friedman, Charles Bennett
BACKGROUND: In this study we aimed to determine the relationship between prostate-specific antigen (PSA)-related information obtained from the provider and PSA test uptake. With recent focus on patient-provider communication (PC) and the guidelines recommending against PSA tests for prostate cancer (PCa), PC regarding the PSA test might affect PSA screening rates. MATERIALS AND METHODS: We used the fourth edition of the Health Information National Trends Survey, a nationally-representative US survey on the use of cancer-related information...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28606735/neutrophil-to-lymphocyte-ratio-in-castration-resistant-prostate-cancer-patients-treated-with-daily-oral-corticosteroids
#7
Niven Mehra, Adam Sharp, David Lorente, David Dolling, Semini Sumanasuriya, Bernadette Johnson, David Dearnaley, Chris Parker, Johann de Bono
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) has been shown to be highly prognostic across many tumor types, and predictive of treatment outcome in advanced prostate cancer, and has been postulated to be an indirect measure of tumor inflammation. We evaluated the effect of low-dose steroids on NLR in men suffering from castration-resistant prostate cancer (CRPC). PATIENTS AND METHODS: The NLR was evaluated in a prospective randomized phase II trial that compared prednisolone 5 mg twice daily and dexamethasone 0...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28587816/prognostic-value-of-the-preoperative-platelet-to-leukocyte-ratio-for-oncologic-outcomes-in-patients-undergoing-radical-cystectomy-for-bladder-cancer
#8
Gerald B Schulz, Tobias Grimm, Alexander Buchner, Friedrich Jokisch, Markus Grabbert, Birte-Swantje Schneevoigt, Alexander Kretschmer, Christian G Stief, Alexander Karl
BACKGROUND: Currently, stratification of patients with bladder cancer (BC) mainly relies on histopathologic and clinical staging. Furthermore, inflammation plays an important role in the pathogenesis of BC. With the preoperative platelet-to-leukocyte ratio (PLR), we introduce a novel prognostic marker based on routine hematologic values in patients undergoing radical cystectomy (RC). PATIENTS AND METHODS: In our cohort of 665 patients undergoing RC (2004-2015) for urothelial carcinoma of the bladder (UCB), we analyzed a variety of preoperative hematologic parameters...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28579151/validation-of-the-association-of-recist-changes-with-survival-in-men-with-metastatic-castration-resistant-prostate-cancer-treated-on-swog-study-s0421
#9
Guru Sonpavde, Gregory R Pond, Melissa Plets, Catherine M Tangen, Maha H A Hussain, Primo N Lara, Amir Goldkorn, Mark G Garzotto, Philip C Mack, Celestia S Higano, Nicholas J Vogelzang, Ian M Thompson, Przemyslaw W Twardowski, Peter J Van Veldhuizen, Neeraj Agarwal, Michael A Carducci, J Paul Monk, David I Quinn
BACKGROUND: Phase 2 trials evaluating new agents for metastatic castration-resistant prostate cancer (mCRPC) have relied on bone scan and prostate-specific antigen changes to assess activity. Given the increasing detection of measurable disease, Response Evaluation Criteria in Solid Tumors (RECIST) changes warrant consideration to evaluate activity. We validated the association of RECIST 1.0 changes with survival in men with mCRPC receiving docetaxel. PATIENTS AND METHODS: Data for men with measurable disease from the Southwest Oncology Group (SWOG) S0421, a phase 3 trial in men with mCRPC receiving docetaxel and prednisone plus placebo or atrasentan, were used...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28571826/mucinous-signet-ring-urachal-carcinoma-of-the-bladder-case-report-and-review-of-the-literature
#10
Jeanny B Aragon-Ching, Simon Chung, Edmond Paquette, Kimberly Woodward, Brant Wang
No abstract text is available yet for this article.
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28566202/management-of-renal-masses-in-an-octogenarian-cohort-is-there-a-right-approach
#11
Dominic H Tang, Jude Nawlo, Juan Chipollini, Scott M Gilbert, Michael Poch, Julio M Pow-Sang, Wade J Sexton, Philippe E Spiess
BACKGROUND: We reviewed the outcomes for an octogenarian population to investigate whether active surveillance (AS) provides comparable survival to partial nephrectomy (PN) or radical nephrectomy (RN). PATIENTS AND METHODS: Data were collected from 115 octogenarian patients referred for management of renal masses at Moffitt Cancer Center from 2000 to 2013. Patients were treated with AS, PN, or RN. Univariable and multivariable Cox regression models measured the association between management modality and survival...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28558990/utilization-of-pelvic-lymph-node-dissection-for-patients-with-low-risk-prostate-cancer-treated-with-robot-assisted-radical-prostatectomy
#12
Parth K Modi, Megan Bock, Sinae Kim, Eric A Singer, Rahul R Parikh
INTRODUCTION: Pelvic lymph node dissection (PLND) is not recommended for low-risk prostate cancer (PCa) patients. However, the rate of PLND in this population is unknown. METHODS: We queried the National Cancer Data Base for PCa patients who underwent robot-assisted radical prostatectomy from 2010 to 2013 and stratified them by D'Amico risk classification. We identified the frequency of PLND in low-risk patients and identified factors associated with receipt of PLND...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28558989/preoperative-cholesterol-level-is-associated-with-worse-pathological-outcomes-and-postoperative-survival-in-localized-renal-cell-carcinoma-patients-a-propensity-score-matched-study
#13
Hakmin Lee, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Seong Il Seo, Hyun Moo Lee, Jong Jin Oh, Sang Chul Lee, Sung Kyu Hong, Sang Eun Lee, Seok-Soo Byun
INTRODUCTION: Lipid metabolism has been suggested to be associated with clinical outcomes of renal cell carcinoma (RCC). In this study, we aimed to investigate the relationship between preoperative cholesterol level (PCL) and postoperative outcomes of patients with localized RCC. MATERIALS AND METHODS: We retrospectively analyzed the data of 5022 patients surgically treated for nonmetastatic RCC. According to the receiver operating curve of PCL for cancer-specific mortality, we stratified the patients into 2 groups by using a cutoff value of 161 mg/dL...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28558988/association-of-distance-to-treatment-facility-with-survival-and-quality-outcomes-after-radical-cystectomy-a-multi-institutional-study
#14
Ahmed Q Haddad, Ryan Hutchinson, Erika L Wood, Gus Miranda, Boris Gershman, Jamie Messer, Robert Svatek, Peter C Black, Stephen A Boorjian, Jay Shah, Siamak Daneshmand, Yair Lotan
BACKGROUND: We sought to determine the effect of the travel distance on mortality and quality outcomes after radical cystectomy in a large multi-institutional cohort. PATIENTS AND METHODS: A total of 3957 patients who had undergone radical cystectomy for urothelial carcinoma at 6 North American tertiary care institutions were included. The association of travel distance with quality-of-care endpoints, 90-day mortality, and long-term survival were evaluated. RESULTS: The median patient age was 69 years (interquartile range, 61-76 years), and most patients were men (80%)...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28558986/tolerance-of-orthotopic-ileal-neobladders-to-radiotherapy-a-multi-institutional-retrospective-study
#15
Leslie Ballas, Paul Sargos, Mathieu Orré, Shelly X Bian, Siamak Daneshmand, Libni J Eapen
BACKGROUND: The present retrospective study analyzed the tolerance of orthotopic ileal neobladders to radiotherapy by reviewing the acute and late toxicity in patients who underwent postoperative radiotherapy after radical cystectomy/cystoprostatectomy. MATERIALS AND METHODS: A multi-institutional database was created for patients who had undergone radical cystectomy/cystoprostatectomy and neobladder reconstruction, followed by adjuvant radiotherapy (RT). The patient and tumor characteristics were recorded...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28552573/evaluation-of-the-clinical-utility-of-renin-angiotensin-system-inhibitors-in-patients-undergoing-radical-surgery-for-urothelial-carcinoma-of-the-upper-urinary-tract
#16
Takashi Yoshida, Tomoaki Matsuzaki, Takashi Murota, Gen Kawa, Tadashi Matsuda, Hidefumi Kinoshita
BACKGROUND: Renin-angiotensin system (RAS) inhibitors are effective for treating patients with cancer. The present study evaluated the impact of RAS inhibitors, including angiotensin-2 converting enzyme inhibitors and angiotensin 2 receptor blockers, after patients underwent radical surgery for upper urinary tract urothelial carcinoma (UTUC). METHODS: This retrospective study included 312 patients with nonmetastatic UTUC who underwent radical surgery. The oncological outcomes of patients treated or not treated with RAS inhibitors following surgery were evaluated...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28552572/drug-interaction-with-sunitinib-and-the-evidence-of-therapeutic-drug-monitoring-a-case-report-and-review-of-the-literature
#17
Pauline Bertolaso, Marine Gross-Goupil, Mathieu Molimard, Valérie Cochin, Alain Ravaud, Amaury Daste
No abstract text is available yet for this article.
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28552571/prognostic-factors-for-survival-of-patients-with-synchronous-or-metachronous-brain-metastasis-of-renal-cell-carcinoma
#18
Se Young Choi, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: We evaluated the oncological outcomes of synchronous or metachronous brain metastasis (BM) of metastatic renal cell carcinoma (RCC) according to clinicopathologic factors. PATIENTS AND METHODS: Patients with metastatic RCC (n = 93) with synchronous and metachronous BM were retrospectively identified. We analyzed patients and tumor characteristics, treatment methods, prognostic factors, BM progression, and overall survival (OS). RESULTS: Seventy-six patients (81...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28528087/prognostic-value-of-inflammatory-and-nutritional-scores-in-renal-cell-carcinoma-after-nephrectomy
#19
Ding Peng, Zhi-Song He, Xue-Song Li, Qi Tang, Lei Zhang, Kai-Wei Yang, Xiao-Teng Yu, Cui-Jian Zhang, Li-Qun Zhou
INTRODUCTION: We compared the prognostic significance of inflammatory and nutritional scores, including the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with renal cell carcinoma (RCC) undergoing nephrectomy. PATIENTS AND METHODS: We retrospectively analyzed the data from 1360 patients with RCC undergoing nephrectomy from 2001 to 2010. The PNI was calculated as the serum albumin level (g/L) + 5 × lymphocyte count (10(9)/L)...
April 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28571827/effect-on-overall-survival-of-locoregional-treatment-in-a-cohort-of-de-novo-metastatic-prostate-cancer-patients-a-single-institution-retrospective-analysis-from-the-royal-marsden-hospital
#20
Diletta Bianchini, David Lorente, Pasquale Rescigno, Zafeiris Zafeiriou, Elena Psychopaida, Hazel O'Sullivan, Mervyn Alaras, Michael Kolinsky, Semini Sumanasuriya, Mariane Sousa Fontes, Joaquin Mateo, Raquel Perez Lopez, Nina Tunariu, Nikolaos Fotiadis, Pardeep Kumar, Alison Tree, Nicholas Van As, Vincent Khoo, Chris Parker, Rosalind Eeles, Alan Thompson, David Dearnaley, Johann S de Bono
BACKGROUND: The optimal management of the primary tumor in metastatic at diagnosis (M1) prostate cancer (PCa) patients is not yet established. We retrospectively evaluated the effect of locoregional treatment (LRT) on overall survival (OS) hypothesizing that this could improve outcome through better local disease control and the induction of an antitumor immune response (abscopal effect). PATIENTS AND METHODS: M1 at diagnosis PCa patients referred to the Prostate Targeted Therapy Group at the Royal Marsden between June 2003 and December 2013 were identified...
April 26, 2017: Clinical Genitourinary Cancer
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