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PET Clinics

journal
https://www.readbyqxmd.com/read/27863571/precision-medicine-and-pet-computed-tomography-time-has-arrived
#1
EDITORIAL
Rathan M Subramaniam
No abstract text is available yet for this article.
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863570/radionuclide-therapies-in-molecular-imaging-and-precision-medicine
#2
REVIEW
A Tuba Kendi, Valeria M Moncayo, Jonathon A Nye, James R Galt, Raghuveer Halkar, David M Schuster
This article reviews recent advances and applications of radionuclide therapy. Individualized precision medicine, new treatments, and the evolving role of radionuclide therapy are discussed.
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863569/molecular-imaging-and-precision-medicine-in-prostate-cancer
#3
REVIEW
Francesco Ceci, Michelangelo Fiorentino, Paolo Castellucci, Stefano Fanti
The aim of the present review is to discuss about the role of new probes for molecular imaging in the evaluation of prostate cancer (PCa). This review focuses particularly on the role of new promising radiotracers for the molecular imaging with PET/computed tomography in the detection of PCa recurrence. The role of these new imaging techniques to guide lesion-target therapies and the potential application of these molecular probes as theranostics agents is discussed. Finally, the molecular mechanisms underlying resistance to castration in PCa and the maintenance of active androgen receptor are discussed...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863568/molecular-imaging-and-precision-medicine-in-head-and-neck-cancer
#4
REVIEW
Esther Mena, Shwetha Thippsandra, Anusha Yanamadala, Siddaling Redy, Puskar Pattanayak, Rathan M Subramaniam
The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863567/advancing-precision-nuclear-medicine-and-molecular-imaging-for-lymphoma
#5
REVIEW
Chadwick L Wright, Joseph J Maly, Jun Zhang, Michael V Knopp
PET with fluorodeoxyglucose F 18 ((18)F FDG-PET) is a meaningful biomarker for the detection, targeted biopsy, and treatment of lymphoma. This article reviews the evolution of (18)F FDG-PET as a putative biomarker for lymphoma and addresses the current capabilities, challenges, and opportunities to enable precision medicine practices for lymphoma. Precision nuclear medicine is driven by new imaging technologies and methodologies to more accurately detect malignant disease. Although quantitative assessment of response is limited, such technologies will enable a more precise metabolic mapping with much higher definition image detail and thus may make it a robust and valid quantitative response assessment methodology...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863566/molecular-imaging-and-precision-medicine-in-lung-cancer
#6
REVIEW
Katherine A Zukotynski, Victor H Gerbaudo
Precision medicine allows tailoring of preventive or therapeutic interventions to avoid the expense and toxicity of futile treatment given to those who will not respond. Lung cancer is a heterogeneous disease functionally and morphologically. PET is a sensitive molecular imaging technique with a major role in the precision medicine algorithm of patients with lung cancer. It contributes to the precision medicine of lung neoplasia by interrogating tumor heterogeneity throughout the body. It provides anatomofunctional insight during diagnosis, staging, and restaging of the disease...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863565/molecular-imaging-and-precision-medicine-in-breast-cancer
#7
REVIEW
Amy V Chudgar, David A Mankoff
Precision medicine, basing treatment approaches on patient traits and specific molecular features of disease processes, has an important role in the management of patients with breast cancer as targeted therapies continue to improve. PET imaging offers noninvasive information that is complementary to traditional tissue biomarkers, including information about tumor burden, tumor metabolism, receptor status, and proliferation. Several PET agents that image breast cancer receptors can visually demonstrate the extent and heterogeneity of receptor-positive disease and help predict which tumors are likely to respond to targeted treatments...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863564/designing-and-developing-pet-based-precision-model-in-thyroid-carcinoma-the-potential-avenues-for-a-personalized-clinical-care
#8
REVIEW
Sandip Basu, Rahul Vithalrao Parghane
This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA)...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863563/molecular-imaging-and-precision-medicine-in-dementia-and-movement-disorders
#9
REVIEW
Atul K Mallik, Alexander Drzezga, Satoshi Minoshima
Precision medicine (PM) has been defined as "prevention and treatment strategies that take individual variability into account." Molecular imaging (MI) is an ideally suited tool for PM approaches to neurodegenerative dementia and movement disorders (MD). Here we review PM approaches and discuss how they may be applied to other associated neurodegenerative dementia and MD. With ongoing major therapeutic research initiatives that include the use of molecular imaging, we look forward to established interventions targeted to specific molecular pathophysiology and expect the potential benefit of MI PM approaches in neurodegenerative dementia and MD will only increase...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863562/molecular-imaging-and-precision-medicine-pet-computed-tomography-and-therapy-response-assessment-in-oncology
#10
REVIEW
Sara Sheikhbahaei, Esther Mena, Puskar Pattanayak, Mehdi Taghipour, Lilja B Solnes, Rathan M Subramaniam
A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and these allow more accurate therapy response assessment and survival prognostication. Multiple studies have addressed the utility of the volumetric PET biomarkers as prognostic indicators but there is no consensus about the preferred segmentation methodology for these metrics...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27863561/precision-medicine-and-pet-computed-tomography-challenges-and-implementation
#11
REVIEW
Rathan M Subramaniam
Precision Medicine is about selecting the right therapy for the right patient, at the right time, specific to the molecular targets expressed by disease or tumors, in the context of patient's environment and lifestyle. Some of the challenges for delivery of precision medicine in oncology include biomarkers for patient selection for enrichment-precision diagnostics, mapping out tumor heterogeneity that contributes to therapy failures, and early therapy assessment to identify resistance to therapies. PET/computed tomography offers solutions in these important areas of challenges and facilitates implementation of precision medicine...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27593253/pet-mr-imaging-clinical-applications
#12
EDITORIAL
Drew A Torigian, Andreas Kjær, Habib Zaidi, Abass Alavi
No abstract text is available yet for this article.
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593252/clinical-pet-mr-imaging-in-oncology-future-perspectives
#13
REVIEW
Andreas Kjær, Drew A Torigian
In 2011, the first fully integrated commercially available clinical PET/MR imaging systems became available, and the imaging community thought that these scanners would replace PET/CT systems. However, today a disappointing number of less than 100 scanners have been installed worldwide. The question, therefore, arises regarding what the future clinical applications of PET/MR imaging will be. In this article, the authors discuss ways in which PET/MR imaging may be used in future applications that justify the added cost, predominantly focusing on oncologic applications...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593251/pet-mr-imaging-in-vascular-disease-atherosclerosis-and-inflammation
#14
REVIEW
Rasmus Sejersten Ripa, Sune Folke Pedersen, Andreas Kjær
For imaging of atherosclerotic disease, lumenography using computed tomography, ultrasonography, or invasive angiography is still the backbone of evaluation. However, these methods are less effective to predict the likelihood of future thromboembolic events caused by vulnerability of plaques. PET and MR imaging have been used separately with success for plaque characterization. Where MR imaging has the ability to reveal plaque composition, PET has the ability to visualize plaque activity. Together this leads to a comprehensive evaluation of plaque vulnerability...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593250/pet-mr-imaging-in-heart-disease
#15
REVIEW
Christoph Rischpler, Stephan G Nekolla
Hybrid PET/MR imaging is a complex imaging modality that has raised high expectations not only for oncological and neurologic imaging applications, but also for cardiac imaging applications. Initially, physicians and physicists had to become accustomed to technical challenges including attenuation correction, gating, and more complex workflow and more elaborate image analysis as compared with PET/CT or standalone MR imaging. PET/MR imaging seems to be particularly valuable to assess inflammatory myocardial diseases (such as sarcoidosis), to cross-validate PET versus MR imaging data (eg, myocardial perfusion imaging), and to help validate novel biomarkers of various disease states (eg, postinfarction inflammation)...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593249/pet-mr-imaging-in-musculoskeletal-disorders
#16
REVIEW
Kim Francis Andersen, Karl Erik Jensen, Annika Loft
There is emerging evidence suggesting that PET/MR imaging will have a role in many aspects of musculoskeletal imaging. The synergistic potential of hybrid PET/MR imaging in terms of acquiring anatomic, molecular, and functional data simultaneously seems advantageous in the diagnostic workup, treatment planning and monitoring, and follow-up of patients with musculoskeletal malignancies, and may also prove helpful in assessment of musculoskeletal infectious and inflammatory disorders. The application of more sophisticated MR imaging sequences and PET radiotracers other than FDG in the diagnostic workup and follow-up of patients with musculoskeletal disorders should be explored...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593248/clinical-pet-mr-imaging-in-dementia-and-neuro-oncology
#17
REVIEW
Otto M Henriksen, Lisbeth Marner, Ian Law
The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593247/the-emerging-role-of-pet-mr-imaging-in-gynecologic-cancers
#18
REVIEW
Maria Rosana Ponisio, Kathryn J Fowler, Farrokh Dehdashti
This article summarizes recent advances in PET/MR imaging in gynecologic cancers and the emerging clinical value of PET/MR imaging in the management of the 3 most common gynecologic malignancies: cervical, endometrial, and ovarian cancers. PET/MR imaging offers superior soft tissue contrast, improved assessment of primary tumor involvement because of high-resolution multiplanar reformats, and functional MR techniques such as diffusion-weighted MR imaging and dynamic contrast-enhanced MR imaging. This article discusses the challenges, future directions, and technical advances of PET/MR imaging, and the emerging new multimodality, multiparametric imaging techniques for integrating morphologic, functional, and molecular imaging data...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593246/pet-mr-imaging-in-cancers-of-the-gastrointestinal-tract
#19
REVIEW
Raj Mohan Paspulati, Amit Gupta
PET/computed tomography (PET/CT) is an established hybrid imaging technique for staging and follow-up of gastrointestinal (GI) tract malignancies, especially for colorectal carcinoma. Dedicated hybrid PET/MR imaging scanners are currently available for clinical use. Although they will not replace regular use of PET/CT, they may have utility in selected cases of GI tract malignancies. The superior soft tissue contrast resolution and depiction of anatomy and the functional information obtained from diffusion-weighted imaging (DWI) provided by MR imaging in PET/MR imaging are advantages over CT of PET/CT for T staging and follow-up of rectal carcinoma and for better characterization of liver lesions...
October 2016: PET Clinics
https://www.readbyqxmd.com/read/27593245/clinical-pet-mr-imaging-in-breast-cancer-and-lung-cancer
#20
REVIEW
Samuel L Rice, Kent P Friedman
Hybrid imaging systems have dramatically improved thoracic oncology patient care over the past 2 decades. PET-MR imaging systems have the potential to further improve imaging of thoracic neoplasms, resulting in diagnostic and therapeutic advantages compared with current MR imaging and PET-computed tomography systems. Increasing soft tissue contrast and lesion sensitivity, improved image registration, reduced radiation exposure, and improved patient convenience are immediate clinical advantages. Multiparametric quantitative imaging capabilities of PET-MR imaging have the potential to improve understanding of the molecular mechanisms of cancer and treatment effects, potentially guiding improvements in diagnosis and therapy...
October 2016: PET Clinics
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