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PET Clinics

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https://www.readbyqxmd.com/read/30219193/evolving-role-of-pet-computed-tomography-and-pet-mr-imaging-in-assessment-of-musculoskeletal-disorders-and-its-potential-revolutionary-impact-on-day-to-day-practice-of-related-disciplines
#1
EDITORIAL
Ali Gholamrezanezhad, Ali Guermazi, Ali Salavati, Abass Alavi
No abstract text is available yet for this article.
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219192/applications-of-pet-ct-and-pet-mr-imaging-in-primary-bone-malignancies
#2
REVIEW
Ashkan Heshmatzadeh Behzadi, Syed Imran Raza, John A Carrino, Christos Kosmas, Ali Gholamrezanezhad, Kyle Basques, George R Matcuk, Jay Patel, Hossein Jadvar
Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. This article reviews the current role of PET/computed tomography scanning and PET/MRI in primary malignancies of bone, with an emphasis on imaging characteristics, clinical usefulness, and current limitations...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219191/pet-in-the-diagnostic-management-of-soft-tissue-sarcomas-of-musculoskeletal-origin
#3
REVIEW
Sanaz Katal, Ali Gholamrezanezhad, Michael Kessler, Mojtaba Olyaei, Hossein Jadvar
Soft tissue sarcomas (STSs) account for less than 1% of adult solid tumors and about 7% of pediatric malignancies, causing 2% of cancer-related deaths. With the advent of PET-computed tomography (CT), the value of (18) fluorine-2-fluoro-2-deoxy-d-glucose (FDG) PET imaging to improve the management of STSs has been explored. FDG PET imaging has been found useful in restaging and treatment response assessment. This article reviews current knowledge and application of FDG PET-CT in initial diagnosis, staging, restaging, treatment response monitoring, and prognosis, with a brief overview of the most common histologic subtypes of STS...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219190/musculoskeletal-pitfalls-on-fluorodeoxyglucose-f-18-pet-computed-tomography-pictorial-review
#4
REVIEW
Mariet Asadoorian, George R Matcuk, Dakshesh B Patel, Anderanik Tomasian, Heidi R Wassef, Eric A White
A wide range of musculoskeletal processes can demonstrate increased uptake on PET-computed tomography (CT) with fluorodeoxyglucose (FDG) F 18, including reactive, benign neoplastic, inflammatory, traumatic, posttreatment, and arthritic conditions that may mimic malignancy. In addition, physiologic causes of increased FDG uptake such as asymmetric muscle use and presence of brown fat can lead to increased FDG uptake and potential false-positive results. This article presents various case examples of non-malignant musculoskeletal hypermetabolism on 18F-FDG PET-CT and describes useful tools to avoid the potential pitfall of misinterpreting these as malignancy...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219189/percutaneous-minimally-invasive-thermal-ablation-of-musculoskeletal-lesions-usefulness-of-pet-computed-tomography
#5
REVIEW
Anderanik Tomasian, Farrokh Dehdashti, Jack W Jennings
This article discusses the role of PET-computed tomography in percutaneous minimally invasive ablation of osseous metastases including diagnosis and preprocedural factors related to patient selection and procedure planning, intraprocedural imaging guidance, and posttreatment imaging assessment.
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219188/the-role-of-dual-energy-computed-tomography-in-musculoskeletal-imaging
#6
REVIEW
Takeshi Fukuda, Kunihiko Fukuda
Dual-energy computed tomography (DECT) enables material decomposition and virtual monochromatic images by acquiring 2 different energy X-ray data sets. DECT can detect musculoskeletal pathologic conditions that CT alone cannot, and that would otherwise require MR imaging. In this review, the authors discuss several useful techniques and applications of DECT in musculoskeletal research: virtual monochromatic images, virtual noncalcium images, gout, iodine map, and tendons.
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219187/mr-imaging-of-the-musculoskeletal-system-using-ultrahigh-field-7t-mr-imaging
#7
REVIEW
Hamza Alizai, Gregory Chang, Ravinder R Regatte
MR imaging is an indispensable instrument for the diagnosis of musculoskeletal diseases. In vivo MR imaging at 7T offers many advantages, including increased signal-to-noise ratio, higher spatial resolution, improved spectral resolution for spectroscopy, improved sensitivity for X-nucleus imaging, and decreased image acquisition times. There are also however technical challenges of imaging at a higher field strength compared with 1.5 and 3T MR imaging systems. We discuss the many potential opportunities as well as the challenges presented by 7T MR imaging systems and highlight recent developments in in vivo research imaging of musculoskeletal applications in general and cartilage, skeletal muscle, and bone in particular...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219186/mr-imaging-of-joint-infection-and-inflammation-with-emphasis-on-dynamic-contrast-enhanced-mr-imaging
#8
REVIEW
Mikael Boesen, Olga Kubassova, Iwona Sudoł-Szopińska, Mario Maas, Philip Hansen, Janus Damm Nybing, Edwin H Oei, Robert Hemke, Ali Guermazi
Contrast-enhanced MR imaging (CE-MR imaging) is recommended for diagnosis and monitoring of infectious and most inflammatory joint diseases. CE-MR imaging clearly differentiates soft and bony tissue from fluid collections and infectious debris. To improve imaging information, a dynamic CE-MR imaging sequence (DCE-MR imaging) sequence can be applied using fast T1-weighted sequential image acquisition during contrast injection. Use of DCE-MR imaging allows robust extraction of quantitative information regarding blood flow and capillary permeability, especially when dedicated analysis methods and software are used to analyze contrast kinetics...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219185/whole-body-mr-imaging-the-novel-intrinsically-hybrid-approach-to-metastases-myeloma-lymphoma-in-bones-and-beyond
#9
REVIEW
Frederic E Lecouvet, Sandy Van Nieuwenhove, François Jamar, Renaud Lhommel, Ali Guermazi, Vassiliki P Pasoglou
Whole-body MR imaging (WB-MR imaging) has become a modality of choice for detecting bone metastases in multiple cancers, and bone marrow involvement by multiple myeloma or lymphoma. Combination of anatomic and functional sequences imparts an inherently hybrid dimension to this nonirradiating tool and extends the screening of malignancies outside the skeleton. WB-MR imaging outperforms bone scintigraphy and CT and offers an alternative to PET in many tumors by time of lesion detection and assessment of treatment response...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219184/radionuclide-therapy-for-bone-metastases-utility-of-scintigraphy-and-pet-imaging-for-treatment-planning
#10
REVIEW
Hojjat Ahmadzadehfar, Markus Essler, Kambiz Rahbar, Ali Afshar-Oromieh
The skeleton is a common site for cancer metastases. Bone metastases are a major cause of morbidity and mortality and associated with pain, pathologic fractures, spinal cord compression, and decreased survival. Various radionuclides have been used for pain therapy. Recently, an α-emitter has been shown to improve overall survival of patients with bone metastases from castration-resistant prostate cancer and was approved as a therapeutic agent. The aim of this article is to provide an overview regarding state of the art radionuclide therapy options for bone metastases, with focus on the role of PET imaging in therapy planning...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219183/-18-f-sodium-fluoride-pet-ct-and-pet-mr-imaging-of-bone-and-joint-disorders
#11
REVIEW
Mohsen Beheshti
18 F-sodium fluoride (18 F-NaF) PET/CT provides high sensitivity and specificity for the assessment of bone and joint diseases. It is able to accurately differentiate malignant from benign bone lesions, especially when using dynamic quantitative approaches. Its high-quality, clinical accuracy, and high feasibility for patient management and greater availability of PET/CT scanners as well as decreasing trend of the cost of radiotracer all indicate the need to consider the use of 18 F-NaF PET/CT as standard bone imaging, particularly in malignant diseases of the skeleton...
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30219182/pet-computed-tomography-and-pet-mr-imaging-basic-principles-methodology-and-imaging-protocol-for-musculoskeletal-applications
#12
REVIEW
Rahul V Parghane, Sandip Basu
In this review, the fundamentals of PET/CT and PET/MRI are discussed, with their implications for evaluation of musculoskeletal disorders. This article also provides an overview of FDG and non-FDG PET tracers, the different PET, CT and MRI protocols and how they can be employed in an individualized manner in various diseased conditions. The present role and the shortcomings of both modalities have been enumerated.
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30100083/uses-and-opportunities-for-molecular-imaging-in-patients-with-breast-cancer
#13
EDITORIAL
Elizabeth S McDonald, Gary A Ulaner
No abstract text is available yet for this article.
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100082/imaging-tumor-proliferation-in-breast-cancer-current-update-on-predictive-imaging-biomarkers
#14
REVIEW
Azadeh Elmi, Elizabeth S McDonald, David Mankoff
Uncontrolled growth is a hallmark of cancer; imaging cell proliferation can provides an early indicator of therapeutic response. This capability is especially well-matched to the emerging cell cycle-specific chemotherapeutics with the goal of identifying patients that benefit from these treatments early in the course of treatment to guide personalized therapy. This article focuses on investigational cell proliferation imaging PET radiotracers to evaluate tumor proliferation in the setting of cell cycle-targeted chemotherapy and endocrine therapy for metastatic breast cancer...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100081/amino-acid-metabolism-as-a-target-for-breast-cancer-imaging
#15
REVIEW
Gary A Ulaner, David M Schuster
Amino acids are an alternate energy source to glucose, and amino acid metabolism is up-regulated in multiple malignancies, including breast cancers. Multiple amino acid radiotracers have been used to image breast cancer with unique strengths and weaknesses. 11 C-methionine uptake correlates with S-phase fraction in breast cancer and may be useful for evaluation of treatment response. Invasive lobular breast cancers may demonstrate greater 18 F-fluciclovine avidity than 18 F-fluorodeoxyglucose. Thus, different histologic subtypes of breast cancer may use diverse metabolic pathways and may be better imaged by different tracers...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100080/clinical-potential-of-human-epidermal-growth-factor-receptor-2-and-human-epidermal-growth-factor-receptor-3-imaging-in-breast-cancer
#16
REVIEW
Kelly E Henry, Gary A Ulaner, Jason S Lewis
Increased expression of the human epidermal growth factor receptor (HER) protein family are targets in breast cancer for imaging and therapy. Imaging modalities targeting HER2 and HER3 can diagnose breast cancer with a specific, biologically relevant target. Repeat biopsies do not address heterogeneity intratumorally or between primary disease and metastasis. HER2- and HER3-targeted PET is an important tool to diagnose disease in breast cancer and evaluate response to targeted therapies. PET and single photon emission computed tomography with radiolabeled biomolecules can be used to detect and quantify specific targets, conferring a better understanding of the behavior and effectiveness of treatments...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100079/clinical-potential-of-estrogen-and-progesterone-receptor-imaging
#17
REVIEW
Hannah M Linden, Lanell M Peterson, Amy M Fowler
Molecular imaging using 16α-[18 F]fluoro-17β-estradiol (FES) and 18 F-fluoro-furanyl-norprogesterone PET can assess in vivo function of steroid hormone receptors in breast cancer. These experimental agents have been tested in many single-center clinical trials and show promise to elucidate prognosis and predict endocrine therapy response. The current multicenter trial of FES-PET imaging will help bring this radiotracer closer to clinical use. There is tremendous potential for these tracers to advance drug development, enhance understanding of estrogen receptor-positive tumor biology, and personalize treatment...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100078/role-of-fludeoxyglucose-in-breast-cancer-treatment-response
#18
REVIEW
David Groheux
After an overview of the principles of fludeoxyglucose-PET/computed tomography (CT) in breast cancer, its advantages and limits to evaluate treatment response are discussed. The metabolic information is helpful for early assessment of the response to neoadjuvant chemotherapy and could be used to monitor treatment, especially in aggressive breast cancer subtypes. PET/CT is also a powerful method for early assessment of the treatment response in the metastatic setting. It allows evaluation of different sites of metastases in a single examination and detection of a heterogeneous response...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100077/nuclear-medicine-imaging-techniques-for-detection-of-skeletal-metastases-in-breast-cancer
#19
REVIEW
Andrei Iagaru, Ryogo Minamimoto
Bone is the most common site of metastases from advanced breast cancer. Whole-body bone scintigraphy has been most frequently used in the process of managing cancer patients; its advantage is that it provides rapid whole-body imaging for screening of osteoblastic or sclerotic/mixed bone metastases at reasonable cost. Recent advanced techniques, such as single-photon emission computed tomography (SPECT)/CT, quantitative analysis, and bone scan index, contribute to better understanding of the disease state. More recent advances in machines and PET drugs improve the staging of the skeleton with higher sensitivity and specificity...
July 2018: PET Clinics
https://www.readbyqxmd.com/read/30100076/dedicated-breast-gamma-camera-imaging-and-breast-pet-current-status-and-future-directions
#20
REVIEW
Deepa Narayanan, Wendie A Berg
Recent advances in nuclear medicine instrumentation have led to the emergence of improved molecular imaging techniques to image breast cancer: dedicated gamma cameras using γ-emitting 99m Tc-sestamibi and breast-specific PET cameras using 18 F-fluorodeoxyglucose. This article focuses on the current role of such approaches in the clinical setting including diagnosis, assessing local extent of disease, monitoring response to therapy, and, for gamma camera imaging, possible supplemental screening in women with dense breasts...
July 2018: PET Clinics
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