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PET Clinics

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https://www.readbyqxmd.com/read/29157391/lung-cancer
#1
EDITORIAL
Gang Cheng, Tim Akhurst
No abstract text is available yet for this article.
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157390/practical-considerations-for-clinical-pet-mr-imaging
#2
REVIEW
Samuel Galgano, Zachary Viets, Kathryn Fowler, Lael Gore, John V Thomas, Michelle McNamara, Jonathan McConathy
Clinical PET/MR imaging is currently performed at a number of centers around the world as part of routine standard of care. This article focuses on issues and considerations for a clinical PET/MR imaging program, focusing on routine standard-of-care studies. Although local factors influence how clinical PET/MR imaging is implemented, the approaches and considerations described here intend to apply to most clinical programs. PET/MR imaging provides many more options than PET/computed tomography with diagnostic advantages for certain clinical applications but with added complexity...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157389/improved-detection-of-small-pulmonary-nodules-through-simultaneous-mr-pet-imaging
#3
REVIEW
Fernando E Boada, Thomas Koesters, Kai Tobias Block, Hersh Chandarana
Magnetic resonance (MR)/PET scanners provide an imaging platform that enables simultaneous acquisition of MR and PET data in perfect spatial and temporal registration. This feature allows improving image quality for the MR and PET images obtained during the course of an examination. In this work the authors demonstrate the use of prospective MR-based motion tracking information for removing motion blur in MR/PET images of small pulmonary nodules. The theoretical basis for the algorithms is presented alongside clinical examples of its use...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157388/future-directions-in-pet-imaging-of-lung-cancer
#4
REVIEW
Tim Akhurst
There is an ongoing and successful effort in developing new radiopharmaceuticals that coupled with new developments in chemistry and instrumentation offers the potential of rapidly defining imaging biomarkers and theranostic paradigms. The overarching challenge remains in funding and approving such agents; the Food and Drug Administration in the United States is making efforts to improve the process, but the time to release PET agents from the regulator shackles is surely now, to bring to patients the excellence of preclinical work that has already been done...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157387/non-small-cell-lung-cancer-pet-imaging-beyond-f18-fluorodeoxyglucose
#5
REVIEW
Gang Cheng
F18 Flurodeoxyglucose (FDG) is a nonspecific PET tracer representing tumor energy metabolism, with common false-positive and false-negative findings in clinical practice. Non-small cell lung cancer is highly heterogeneous histologically, biologically, and molecularly. Novel PET tracers designed to characterize a specific aspect of tumor biology or a pathway-specific molecular target have the potential to provide noninvasive key information in tumor heterogeneity for patient stratification and in the assessment of treatment response...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157386/prognostic-value-of-18-f-fluorodeoxyglucose-pet-computed-tomography-in-non-small-cell-lung-cancer
#6
REVIEW
Gang Cheng, He Huang
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death with a poor prognosis. Numerous factors contribute to treatment outcome. 18F-fluorodeoxyglucose (FDG) uptake reflects tumor metabolic activity and is an important prognosticator in patients with NSCLC. Volume-based FDG-PET parameters reflect the metabolic status of a malignancy more accurately than maximum standardized uptake value and thus are better prognostic markers in lung cancer. FDG-avid tumor burden parameters may help clinicians to predict treatment outcomes before and during therapy so that treatment can be adjusted to achieve the best possible outcomes while avoiding side effects...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157385/treatment-planning-for-radiation-therapy
#7
REVIEW
Michael MacManus, Sarah Everitt
PET scanning plays key roles in planning the management of patients with lung cancer who are candidates for curative-intent treatment with radiotherapy and has contributed to improvements in survival. (18)F-fluorodeoxyglucose-PET is the most important modality for staging, patient selection, and radiotherapy target volume definition in patients with unresectable non-small cell lung cancer. Developments include the availability of alternative tracers, such as (18)F-fluorothymidine, for imaging proliferation and a range of hypoxia imaging agents...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157384/genomic-characterization-of-lung-cancer-and-its-impact-on-the-use-and-timing-of-pet-in-therapeutic-response-assessment
#8
REVIEW
Lavinia Tan, Benjamin Solomon
Significant advances in understanding the genomic landscape of non-small cell lung cancer (NSCLC) together with the coupling discovery of key oncogenic drivers and the development of effective targeted and immunotherapeutic agents have revolutionized the management of this malignancy. Although these therapies have resulted in improved outcomes for a subgroup of patients, their benefit may not necessarily be reflected by conventional response assessment criteria, because these therapeutic agents differ in their mechanism of action and response time compared with cytotoxic chemotherapy...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157383/18f-fluoro-2-deoxy-d-glucose-pet-computed-tomography-evaluation-of-lung-cancer-in-populations-with-high-prevalence-of-tuberculosis-and-other-granulomatous-disease
#9
REVIEW
Alexandre Niyonkuru, Khamis Hassan Bakari, Xiaoli Lan
Pulmonary tuberculosis infects one-third of world's population and is responsible for the high mortality and morbidity in developing countries. The presence of a high number of macrophages and lymphocytes in active tuberculosis granulomas is associated with high uptake of 18F-fluoro-2-deoxy-d-glucose on PET imaging mimicking lung cancer. In many cases, radiological features of pulmonary tuberculosis are undistinguishable from lung cancer, which makes the diagnosis difficult. Clinical history and computed tomographic (CT) findings on a hybrid PET/CT are as important as findings on a PET in the diagnosis of lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157382/diagnostic-imaging-and-newer-modalities-for-thoracic-diseases-pet-computed-tomographic-imaging-and-endobronchial-ultrasound-for-staging-and-its-implication-for-lung-cancer
#10
REVIEW
Sarah J Counts, Anthony W Kim
Modalities to detect and characterize lung cancer are generally divided into those that are invasive [endobronchial ultrasound (EBUS), esophageal ultrasound (EUS), and electromagnetic navigational bronchoscopy (ENMB)] versus noninvasive [chest radiography (CXR), computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI)]. This chapter describes these modalities, the literature supporting their use, and delineates what tests to use to best evaluate the patient with lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157381/lung-neoplasms-with-low-f18-fluorodeoxyglucose-avidity
#11
REVIEW
Yiyan Liu
Some malignant lung neoplasms may demonstrate low or absent uptake on F18-fluorodeoxyglucose (FDG) PET/computed tomography. Pathologic type and clinical stage are independent factors associated with FDG avidity. Among lung malignancies with low FDG avidity, adenocarcinoma in situ and carcinoid are the most common. Early stage disease often has low FDG uptake. Small lesion size is another significant factor associated with negative FDG PET findings, which is due to a partial volume effect. Morphology of lung lesions on anatomic images may also affect FDG avidity...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29157380/staging-of-non-small-cell-lung-cancer
#12
REVIEW
Tim Akhurst
Staging of lung cancer serves 2 purposes; it attempts to classify patients into groups where particular treatments are appropriate and defines those groups based on expected prognosis. The eighth edition of the International Association for the Study of Lung Cancer staging system deals with the issues raised by screening with fine cut computed tomography. Each phase of staging is a legitimate dataset on its own. Molecular profiling of lung cancer has led to the development of an increasing number of novel agents to treat systemic disease...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/28867119/precision-medicine-and-pet-computed-tomography-emerging-themes-for-future-clinical-practice
#13
EDITORIAL
Rathan M Subramaniam
No abstract text is available yet for this article.
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867118/the-role-of-pet-mr-imaging-in-precision-medicine
#14
REVIEW
Eugene Huo, David M Wilson, Laura Eisenmenger, Thomas A Hope
Fluorodeoxyglucose PET and PET/computed tomography have gained acceptance in the evaluation of disease. Nontargeted tracers have been used in the diagnosis of certain malignancies but may not be sensitive or specific enough to become standard of care. Newer targeted PET tracers have been developed that target disease-specific biomarkers, and allow accurate and sensitive detection of disease. Combined with the capabilities of MR imaging to evaluate soft tissue, precision imaging with PET/MR imaging can change the diagnosis...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867117/pet-computed-tomography-and-precision-medicine-musculoskeletal-sarcoma
#15
REVIEW
Asha Kandathil, Rathan M Subramaniam
Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome. (18)F-FDG PET/computed tomography (CT) is indicated in staging of patients with high-grade sarcomas and acts as a surrogate marker of histopathologic grade, guiding biopsy to most aggressive portion of the tumor. Pretherapy and posttherapy (18)F-FDG PET/CT metabolic parameters are reliable indicators of survival in patients with sarcoma with an important role in posttreatment response assessment, enabling the treatment plan to be modified in nonresponders...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867116/precision-medicine-and-pet-computed-tomography-in-cardiovascular-disorders
#16
REVIEW
Elizabeth H Dibble, Don C Yoo
PET/computed tomography (CT) can evaluate the metabolic and anatomic involvement of a variety of inflammatory, infectious, and malignant cardiovascular disorders. PET/CT is useful in evaluating coronary vasculature, hibernating myocardium, cardiac sarcoidosis, cardiac amyloidosis, cerebrovascular disease, acute aortic syndromes, cardiac and vascular neoplasms, cardiac and vascular infections, and vasculitis. Novel targeted radiopharmaceutical agents and novel use of established techniques show promise in diagnosing and monitoring cardiovascular diseases...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867115/precision-medicine-and-pet-computed-tomography-in-melanoma
#17
REVIEW
Esther Mena, Yasemin Sanli, Charles Marcus, Rathan M Subramaniam
Recent advances in genomic profiling and sequencing of melanoma have provided new insights into the development of the basis for molecular biology to more accurately subgroup patients with melanoma. The development of novel mutation-targeted and immunomodulation therapy as a major component of precision oncology has revolutionized the management and outcome of patients with metastatic melanoma. PET imaging plays an important role in noninvasively assessing the tumor biological behavior, to guide individualized treatment and assess response to therapy...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867114/pet-computed-tomography-and-precision-medicine-gastric-cancer
#18
REVIEW
Charles Marcus, Rathan M Subramaniam
Gastric cancer is a disease with low survival rates and high morbidity, requiring accurate and prompt diagnosis and treatment. Although limited in the evaluation of the primary tumor as such, the metabolic information of primary tumors in an (18)F-FDG PET/CT study can assist in surgical and treatment planning and differentiating gastric cancers. It detects nodal disease with good specificity and positive predictive value, thus enabling appropriate therapy for individual patients. It provides valuable information about distant metastases, altering therapy decisions...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867113/precision-medicine-and-pet-computed-tomography-in-pediatric-malignancies
#19
REVIEW
Yasemin Sanli, Ebru Yilmaz, Rathan M Subramaniam
Fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET-computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose (18)F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT-based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine ((131)I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28867112/pet-computed-tomography-and-precision-medicine-in-pancreatic-adenocarcinoma-and-pancreatic-neuroendocrine-tumors
#20
REVIEW
Daniella F Pinho, Rathan M Subramaniam
(18)F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, (68)Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. (18)F-FDG PET/CT has a role in patients with poorly differentiated tumors...
October 2017: PET Clinics
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