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Journal of Cardiovascular Medicine

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https://www.readbyqxmd.com/read/29324479/a-systematic-review-of-epidemiology-treatment-and-prognosis-of-heart-failure-in-adults-in-ethiopia
#1
Tenaadam A Tsega, Biniyam G Demissei
BACKGROUND: Systematic characterization of heart failure in adults in Ethiopia is lacking currently. In this review, we sought to summarize the available scientific evidence on the epidemiology, treatment and prognosis of heart failure in adults in Ethiopia. METHODS: A systematic review of PUBMED, EMBASE and SCOPUS was conducted for studies published between January 1990 and July 2017. Studies reporting on incidence, prevalence, treatment or prognosis of heart failure in individuals older than 14 years of age were included...
January 10, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29324478/site-of-entry-and-surgical-timing-in-infective-endocarditis
#2
Francesco Bovenzi, Lucia Borelli, Lauro Cortigiani
: Infective endocarditis is the manifestation of the endocardial involvement during a systemic infectious process.The prognosis of this condition is still dismal, and the mortality associated with it remains high despite improvement in antimicrobial treatment. Antibiotic prophylaxis is still recommended only in high-risk cases, that is, procedures at high risk for inducing systemic bacteremia.It is important to provide an educational prophylaxis consisting of sound hygienic recommendations for the cleansing of the oral cavity, the skin, genital-urinary, and gastrointestinal systems...
January 10, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29283915/diagnostic-power-and-healthcare-resource-consumption-of-a-dedicated-workflow-algorithm-designed-to-manage-thoracic-impedance-alerts-in-heart-failure-patients-by-remote-monitoring
#3
Renato P Ricci, Loredana Morichelli, Antonio Porfili, Laura Quarta, Anna Sassi
PURPOSE: Modern cardiac implantable devices provide diagnostic information on several physiological variables which are associated with worsening heart failure, creating an opportunity for early intervention to prevent heart failure symptoms and hospitalizations. We evaluated diagnostic accuracy and workload of a remote monitoring (RM) workflow algorithm which leverages intrathoracic impedance and other device diagnostics. METHODS: In our RM workflow a team of expert nurses was responsible for continuity of care, direct relationship with patients and implementation of a specific protocol to evaluate RM alerts and to limit unnecessary resource consumption...
December 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29251697/adherence-to-proprotein-convertase-subtilisin-kexin-9-inhibitors-in-high-cardiovascular-risk-patients-an-italian-single-center-experience
#4
Felice Gragnano, Francesco Natale, Claudia Concilio, Fabio Fimiani, Arturo Cesaro, Simona Sperlongano, Mario Crisci, Giuseppe Limongelli, Raffaele Calabrò, Mariagiovanna Russo, Enrica Golia, Paolo Calabrò
: In contemporary practice, adherence to statins is frequently suboptimal in high-risk patients. Levels of adherence to Proprotein Convertase Subtilisin/Kexin 9 inhibitors (PCSK9i) in current clinical practice have not been previously reported. Our study aimed to compare the level of adherence to PCSK9i and statins. We have prospectively evaluated 117 patients at high cardiovascular risk divided into two groups: 39 patients on PCSK9i, and 78 patients on statins. We examined the level of adherence to PCSK9i and statins using pen count, pill count or four-items Morisky scale...
December 14, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29251695/association-of-change-in-5-year-n-terminal-fragment-of-the-prohormone-brain-type-natriuretic-peptide-with-left-ventricular-structure-and-function-in-stable-coronary-disease
#5
Mitchell A Psotka, Nelson B Schiller, Mary A Whooley, Rakesh K Mishra
AIMS: We sought to characterize the association between long-term changes in the N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) and changes in left ventricular (LV) structure and function in patients with stable coronary artery disease. METHODS: We included 593 participants without significant valvular disease enrolled in the Heart and Soul Study. We evaluated the association of 5-year change in NT-proBNP (ΔNT-proBNP) with changes in echocardiography-determined LV ejection fraction (LVEF), LV systolic dysfunction (LVSD; LVEF < 50%), LV mass index, incident LV hypertrophy (LVH) (LV mass index >102 g/m for men and >88 g/m for women), and LV diastolic dysfunction (LVDD) using linear and logistic regression...
December 14, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29227414/the-diagnostic-process-of-stable-angina-still-many-doubts-since-heberden-s-first-description-250-years-ago
#6
Irene Raso, Ilaria Passarelli, Gioacchino Valenti, Gabriele Crimi, Stefano de Servi
: Since Heberden's first description, stable angina has represented a challenge for the clinicians. Even the most recent guidelines seem ineffective to correctly identify patients who should be sent to cath labs. Still too many patients who undergo coronary angiography are found not to have significant lesions; moreover, its extensive use as the first diagnostic test leads to revascularizations with uncertain appropriateness and prognostic significance. These considerations underline the importance of noninvasive testing before sending patients to invasive coronary angiography...
December 8, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#7
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29095731/understanding-myocardial-infarction-evolution-infarct-size-and-index-of-microvascular-resistance-new-clinical-perspective
#8
Massimo Fineschi
: Approximately 40% of patients after ST elevation acute myocardial infarction (STEMI) have evidence of ineffective myocardial revascularization due to microvascular damage despite a successful target vessel recanalization by means of primary angioplasty (PPCI). Microvascular dysfunction is associated with the extension of the infarct size and with higher morbidity and mortality. Early identification of this phenomenon could be useful both for therapeutic and prognostic purposes. Index of microvascular resistance (IMR) could be assessed invasively at the end of PPCI and is a measure of microvascular function...
November 8, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29084021/what-will-be-the-impact-of-sacubitril-valsartan-in-clinical-practice
#9
Marco Metra
: The Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor with Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial has shown a reduction in the risk of death and heart failure hospitalizations with sacubitril/valsartan, compared with enalapril, in patients with heart failure and reduced ejection fraction. Guidelines now recommend the substitution of angiotensin-converting enzyme inhibitor or AT1 blockers with sacubitril/valsartan in the patients who remain symptomatic despite ongoing optimal treatment...
October 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29084020/use-of-implantable-cardioverter-defibrillator-in-nonischaemic-cardiomyopathy-a-u-turn
#10
Fiorenzo Gaita, Davide Castagno, Matteo Anselmino
: Use of implantable cardioverter defibrillator (ICD) in primary prevention has been shown to reduce the risk of death among patients with severe left ventricular systolic dysfunction (LVSD) due to ischaemic cardiomyopathy. However, among patients with heart failure and severe LVSD who do not have coronary artery disease, the evidence of ICD benefit is less robust. As a matter of fact, data supporting the use of ICD in such patients are limited to a few randomized controlled clinical trials that included a small number of patients, subgroup analysis of larger trials or meta-analysis...
October 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29252600/vitamin-d-parathyroid-hormone-and-cardiovascular-risk-the-good-the-bad-and-the-ugly
#11
Antonietta V Pascale, Rosa Finelli, Rocco Giannotti, Valeria Visco, Davide Fabbricatore, Ida Matula, Pietro Mazzeo, Nicola Ragosa, Angelo Massari, Raffaele Izzo, Enrico Coscioni, Maddalena Illario, Michele Ciccarelli, Bruno Trimarco, Guido Iaccarino
: 25-Hydroxyvitamin D insufficiency and increased cardiovascular risk (CVR) association is still debated. The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. To investigate the association of CVR, PTH and VitD, we carried out blood pressure measurements and blood samples and collected information on dietary habits, anamnestic, clinical and metabolic data of 451 participants in the Salerno area (Southern Italy) during the World Hypertension Day (17 May)...
February 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29251698/echo-navigation-to-guide-challenging-transseptal-puncture-during-transfemoral-repair-of-mitral-and-tricuspid-valve
#12
Alberto Pozzoli, Maurizio Taramasso, Marco Russo, Michel Zuber, Francesco Maisano
No abstract text is available yet for this article.
February 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29251696/arterial-hypertension-and-atrial-fibrillation-standard-and-advanced-echocardiography-from-diagnosis-to-prognostication
#13
Matteo Cameli, Giulia E Mandoli, Giuseppe Ambrosio, Elisabetta Cerbai, Stefano Coiro, Michele Emdin, Rossella Marcucci, Doralisa Morrone, Alberto Palazzuoli, Ketty Savino, Luigi Padeletti, Sergio Mondillo, Roberto Pedrinelli
: Structural changes in left and right cardiac chambers that occur in arterial hypertension (AH) may lead to an increased risk of atrial fibrillation. Considering that AH is currently the most common cardiovascular disease in the general population, it represents a major risk factor for atrial fibrillation development. This review explores the complex relationship between atrial fibrillation and AH, starting from its pathophysiological basis. It focuses on the role of echocardiography in the management of hypertensive and atrial fibrillation patients, with emphasis on what should be evaluated about left ventricular remodeling, diastolic and systolic function, left atrial (LA) size and function and right ventricular deformation in patients with AH...
February 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29215547/hypnosis-as-an-effective-and-inexpensive-option-to-control-pain-in-transcatheter-ablation-of-cardiac-arrhythmias
#14
Umberto Barbero, Federico Ferraris, Milena Muro, Carlo Budano, Matteo Anselmino, Fiorenzo Gaita
: Supportive care for pain relief and back discomfort during electrophysiology interventions is usually needed in the electrophysiology lab, especially in long-lasting procedures like atrial fibrillation ablation. Although this is usually achieved with conventional pharmacologic anesthesia, hypnosis has recently aroused interest as a reliable tool to complement and possibly enhance conscious sedation. We collected five case of percutaneous arrhythmia ablation in which, after informed consent, hypnosis was performed by nurse anesthetists in the cath lab...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29215546/initial-tadalafil-and-ambrisentan-combination-therapy-in-pulmonary-arterial-hypertension-clinical-and-haemodynamic-long-term-efficacy-italy-study
#15
Michele D'Alto, Emanuele Romeo, Paola Argiento, Giuseppe Paciocco, Renato Prediletto, Stefano Ghio, Michele Correale, Francesco Lo Giudice, Roberto Badagliacca, Alessandra Greco, Carmine Dario Vizza
AIMS: Initial combination therapy with ambrisentan and tadalafil (upfront therapy) offers clinical benefits in pulmonary arterial hypertension (PAH) and reduces the risk of clinical failure compared with monotherapy in naïve patients. The aim of study is to assess the efficacy of a 12-month upfront therapy with ambrisentan and tadalafil in improving haemodynamics in incident PAH patients. METHODS: This is a multicentre retrospective analysis of real-world Italian clinical data in 56 patients with newly diagnosed PAH...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29206694/diagnosis-and-management-of-a-patient-with-recurrent-variant-angina-and-history-of-percutaneous-coronary-intervention-vasospasm-and-percutaneous-coronary-intervention
#16
Massimo Fineschi, Flavio D'Ascenzi, Vasile Sirbu, Sergio Mondillo, Carlo Pierli
No abstract text is available yet for this article.
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29206693/long-term-results-of-suture-annuloplasty-for-degenerative-mitral-valve-disease-a-propensity-matched-analysis
#17
Andrea Garatti, Alberto Canziani, Alessandro Parolari, Serenella Castelvecchio, Marco Guazzi, Andrea Daprati, Ali Abu Farah, Francesco Grimaldi, Sonia Tripepi, Lorenzo Menicanti
AIMS: Ring annuloplasty is the gold standard of surgical repair in degenerative mitral valve disease. However, prosthetic annuloplasty has some drawbacks and potential hazards. Suture annuloplasty theoretically is able to preserve annular leaflet dynamics and left ventricular performance, but experience is limited. The aim of the study was to review the early and long-term outcome of the posterior double-suture annuloplasty (DSA) technique for degenerative mitral valve repair. METHODS: From January 2002 to December 2008, 400 patients underwent primary mitral valve repair for degenerative disease either with posterior DSA [n = 147 (37%)] or with flexible posterior annuloplasty band [n = 253 (63%)]...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29176389/contemporary-genetic-testing-in-inherited-cardiac-disease-tools-ethical-issues-and-clinical-applications
#18
Francesca Girolami, Giulia Frisso, Matteo Benelli, Lia Crotti, Maria Iascone, Ruggiero Mango, Cristina Mazzaccara, Kalliope Pilichou, Eloisa Arbustini, Benedetta Tomberli, Giuseppe Limongelli, Cristina Basso, Iacopo Olivotto
: Inherited cardiac diseases comprise a wide and heterogeneous spectrum of diseases of the heart, including the cardiomyopathies and the arrhythmic diseases in structurally normal hearts, that is, channelopathies. With a combined estimated prevalence of 3% in the general population, these conditions represent a relevant epidemiological entity worldwide, and are a major cause of cardiac morbidity and mortality in the young. The extraordinary progress achieved in molecular genetics over the last three decades has unveiled the complex molecular basis of many familial cardiac conditions, paving the way for routine use of gene testing in clinical practice...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29045312/validation-of-the-nonlaboratory-based-framingham-cardiovascular-disease-risk-assessment-algorithm-in-the-atherosclerosis-risk-in-communities-dataset
#19
Jacob K Kariuki, Eileen M Stuart-Shor, Suzanne G Leveille, Philimon Gona, Jerry Cromwell, Laura L Hayman
BACKGROUND: Nonlaboratory-based (non-LB) algorithms have been developed to facilitate absolute cardiovascular risk assessment in resource-constrained settings. The non-LB Framingham algorithm, which substitute BMI for lipids in laboratory-based Framingham, exhibits best performance among non-LB algorithms. However, its external validity has not been evaluated. AIM: To examine the validity of non-LB Framingham algorithm in Atherosclerosis Risk in Communities dataset, and contrast performance with the laboratory-based Framingham algorithm...
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29045311/cardiac-resynchronization-therapy-outcomes-in-patients-with-chronic-heart-failure-cardiac-resynchronization-therapy-with-pacemaker-versus-cardiac-resynchronization-therapy-with-defibrillator
#20
Michael Drozd, John Gierula, Judith E Lowry, Maria F Paton, Eleanor Joy, Haqeel A Jamil, Richard M Cubbon, Mark T Kearney, David A Cairns, Klaus K Witte
AIMS: Cardiac resynchronization therapy (CRT) for chronic heart failure with left ventricular systolic dysfunction (LVSD) consistently improves survival against optimal medical therapy alone. Limited data exist comparing the outcomes between CRT with pacemaker (CRT-P) and with defibrillator (CRT-D). We aimed to investigate the long-term prognosis of patients who received CRT-P or CRT-D. METHODS AND RESULTS: Data were prospectively collected from consecutive patients with standard indications for CRT, who were implanted at a single large tertiary centre between 2008 and 2012...
December 2017: Journal of Cardiovascular Medicine
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