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Journal of Cardiovascular Medicine

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https://www.readbyqxmd.com/read/29782370/a-common-polymorphism-in-the-scn5a-gene-is-associated-with-dilated-cardiomyopathy
#1
Cristina Mazzaccara, Giuseppe Limongelli, Mario Petretta, Rossella Vastarella, Giuseppe Pacileo, Domenico Bonaduce, Francesco Salvatore, Giulia Frisso
AIMS: SCN5A is a disease-causing gene associated with familial dilated cardiomyopathy (FDC). We examined the possible association between a common polymorphism in the SCN5A gene (c.1673A>G-p.H558R; rs1805124) and the risk of dilated cardiomyopathy (DCM) occurrence. METHODS: We genotyped 185 DCM cases (familial DCM, idiopathic DCM and postischemic DCM) and 251 controls for the p.H558R polymorphism in the SCN5A gene, to test the association of the molecular epidemiology of the individuals with the presence/absence of various types of DCM...
May 17, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29762337/real-life-indications-to-ivabradine-treatment-for-heart-rate-optimization-in-patients-with-chronic-systolic-heart-failure
#2
Lara Tondi, Gabriele Fragasso, Roberto Spoladore, Giuseppe Pinto, Marco Gemma, Massimo Slavich, Cosmo Godino, Anna Salerno, Claudia Montanaro, Alberto Margonato
: Ivabradine is a selective and specific inhibitor of If current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses...
May 11, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29708911/closure-of-patent-foramen-ovale-or-medical-therapy-alone-for-secondary-prevention-of-cryptogenic-cerebrovascular-events
#3
Federico Fortuni, Gabriele Crimi, Sergio Leonardi, Filippo Angelini, Arturo Raisaro, Luca Franco Lanzarini, Luigi Oltrona Visconti, Maurizio Ferrario, Gaetano Maria De Ferrari
AIMS: About one-third of ischemic stroke are cryptogenic. Paradoxical embolism through patent foramen ovale (PFO) has been identified as a possible cause of cryptogenic stroke. Therefore, PFO closure has been considered for secondary prevention of cryptogenic stroke. However, randomized clinical trials (RCTs) comparing PFO closure versus medical therapy led to conflicting results. Our objectives were to examine if PFO closure is superior to medical therapy alone for secondary prevention of cryptogenic stroke and to investigate whether PFO closure is associated with an increased incidence of atrial fibrillation/atrial flutter (AFL)...
April 27, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29708910/primary-cardiac-lymphoma-the-role-of-multimodality-imaging
#4
Marco A Perrone, Alfredo Intorcia, Riccardo Morgagni, Massimo Marchei, Domenico Sergi, Luca Pugliese, Paolo Ferrante, Marcello Chiocchi, Mauro Borzi, Francesco Romeo
: Primary cardiac lymphoma is a rare form of non-Hodgkin lymphoma that involves the heart and can extend to the pericardium and great vessels. It is estimated that primary cardiac lymphomas account for 1.3% of primary cardiac tumors and 0.5% of all extranodal non-Hodgkin lymphomas. Definitive diagnosis is achieved with cytological and histological evaluation. Processing multimedia images is the best way to evaluate the size and extent of the tumor. Echocardiography, computerized tomography, MRI and PET are the best imaging tools in cardiac tumors...
April 27, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29708912/chemotherapy-induced-cardiotoxicity-new-insights-into-mechanisms-monitoring-and-prevention
#5
Christian Cadeddu Dessalvi, Martino Deidda, Donato Mele, Pier P Bassareo, Roberta Esposito, Ciro Santoro, Maria Lembo, Maurizio Galderisi, Giuseppe Mercuro
: Chemotherapy-induced cardiotoxicity (CTX) remains a determining factor for the quality of life and mortality of patients treated with potentially cardiotoxic drugs. Considerable advances have been made in this field with increase in awareness regarding chemotherapy-induced CTX, which has changed the treatment approach to include cardiovascular risk among the first factors to be evaluated before therapy. Moreover, a better understanding of the pathophysiology of chemotherapy-induced CTX has also facilitated early identification of patients at risk with the help of new imaging technologies...
April 26, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29629921/assessment-of-cardiac-thrombosis-in-patients-with-left-ventricular-assist-device-using-multidetector-cardiac-computed-tomography
#6
Chukwuemeka A Obi, Nicholas Chan, Monica G Rizkalla, John N Makaryus
: A 79-year-old man with nonischemic cardiomyopathy who underwent left ventricular assist device HeartMate II and automated implantable cardioverter defibrillator placement presented with recurrent refractory sustained ventricular tachycardia, elevated lactate dehydrogenase, and low haptoglobin. Echocardiography demonstrated no thrombosis; cardiac computed tomography showed patent inflow and outflow cannulas while detecting an irregularly shaped mass adherent to the left coronary cusp of the aortic valve, suggesting a thrombus...
April 7, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29601309/anatomical-and-procedural-predictors-of-pulmonary-vein-stenosis-in-the-setting-of-second-generation-cryoballoon-ablation
#7
Hugo-Enrique Coutiño, Ken Takarada, Juan Sieira, Juan-Pablo Abugattas, Francesca Salghetti, Valentina De Regibus, Erwin Ströker, Pedro Brugada, Saverio Iacopino, Carlo de Asmundis, Gian-Battista Chierchia
AIMS: Pulmonary vein stenosis (PVS) is a well recognized complication as a consequence of pulmonary vein isolation. In the current study, we sought to analyze potential anatomical and intraprocedural predictors of PVS during second-generation cryoballoon ablation, particularly focusing on the impact of freeze duration and number of cryoapplications. METHODS: Fifty-four patients who underwent cryoballoon ablation for atrial fibrillation were included retrospectively in this study...
March 29, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29601308/real-world-application-of-currently-available-decision-models-for-dual-antiplatelet-therapy-duration-in-acute-coronary-syndrome
#8
Nuccia Morici, Enrico Piccinelli, Dario Brunelli, Alice Sacco, Giovanna Viola, Jacopo A Oreglia, Fabrizio Oliva, Marco Valgimigli
No abstract text is available yet for this article.
March 29, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29570491/characteristics-and-outcome-for-heart-failure-patients-with-mid-range-ejection-fraction
#9
Nelson Wang, Susan Hales, Edward Barin, Geoffrey Tofler
AIMS: The aim of this study was to compare precipitants, presenting symptoms and outcomes of patients with heart failure and mid-range ejection fraction (HFmrEF), heart failure and preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) in an Australian cohort. METHODS: We divided 5236 patients in the Management of Cardiac Failure program in Northern Sydney Australia, into HFmrEF (n = 780, 14.9%), HFpEF (n = 1956, 37...
March 22, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29553993/evolution-of-the-pericardiocentesis-technique
#10
Stefano Maggiolini, Caterina C De Carlini, Massimo Imazio
: Pericardiocentesis is a valuable technique for the diagnosis and treatment of patients with pericardial effusion and cardiac tamponade, although it may be associated with potentially serious complications. Through the years, many different imaging approaches have been described to reduce the complication rate of the procedure. This systematic review provides a focused overview of the different techniques developed in recent years to reduce the procedural complications and to increase the related success rate...
March 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29553992/left-atrial-volume-index-is-critical-for-the-diagnosis-of-heart-failure-with-preserved-ejection-fraction
#11
Pedro Almeida, João Rodrigues, Patricia Lourenço, Maria Julia Maciel, Paulo Bettencourt
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is now well recognized but the identification of patients with HFpEF can be challenging. We aimed to evaluate the performance of tissue Doppler imaging indexes and left atrial size in HFpEF diagnosis. METHODS AND RESULTS: We designed a case-control study in which cases are patients with acute heart failure and controls are age-matched and sex-matched patients with multiple cardiovascular risk factors admitted to hospital because of stroke...
March 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29553991/intracoronary-versus-intravenous-adenosine-to-assess-fractional-flow-reserve-a-systematic-review-and-meta-analysis
#12
Sebastiano Gili, Umberto Barbero, Daniele Errigo, Giuseppe De Luca, Giuseppe Biondi-Zoccai, Antonio Maria Leone, Mario Iannaccone, Antonio Montefusco, Pierluigi Omedé, Claudio Moretti, Maurizio D'Amico, Fiorenzo Gaita, Fabrizio D'Ascenzo
AIMS: Intravenous infusion of adenosine is the reference method to measure fractional flow reserve (FFR). Intracoronary boluses are often used because of time and convenience, but their effectiveness has yet to be assessed. METHODS: We conducted a systematic review and meta-analysis of prospective studies directly comparing intravenous and intracoronary adenosine administration for FFR measurement. FFR values and prevalence of functionally critical lesions obtained with the different methods of adenosine administration were compared...
March 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29697582/cardiovascular-pharmacotherapy-a-growing-sub-speciality-across-all-areas-of-cardiology-a-european-tradition
#13
Giuseppe M C Rosano
No abstract text is available yet for this article.
June 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29601310/ticagrelor-related-late-onset-dyspnea-as-cause-of-emergency-department-visit-a-3-year-outpatient-study
#14
Niccolò Lombardi, Ersilia Lucenteforte, Monica Torrini, Daniela Balzi, Alessandro Barchielli, Alessandro Mugelli, Alfredo Vannacci
INTRODUCTION: The aim of the current study was to define the rate of emergency department visits for late-onset dyspnea in acute coronary syndrome patients treated with ticagrelor. METHODS: We conducted a population-based study on about 850 000 residents of Florence metropolitan area, by using data from healthcare records. RESULTS: Between 2012 and 2014, 1073 subjects in Florence metropolitan area had at least one prescription of ticagrelor...
June 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29578922/old-methods-of-myocardial-revascularization-to-treat-refractory-angina
#15
Marco Picichè
No abstract text is available yet for this article.
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29578921/updated-clinical-indications-for-transcatheter-aortic-valve-implantation-in-patients-with-severe-aortic-stenosis-expert-opinion-of-the-italian-society-of-cardiology-and-gise
#16
Ciro Indolfi, Antonio L Bartorelli, Sergio Berti, Paolo Golino, Giovanni Esposito, Giuseppe Musumeci, Sonia Petronio, Corrado Tamburino, Giuseppe Tarantini, Gianpaolo Ussia, Corrado Vassanelli, Carmen Spaccarotella, Roberto Violini, Giuseppe Mercuro, Francesco Romeo
: The introduction of percutaneous treatment of severe aortic stenosis with transcatheter aortic valve implantation (TAVI) remains one of the greatest achievements of interventional cardiology. In fact, TAVI emerged as a better option than either medical therapy or balloon aortic valvuloplasty for patients who cannot undergo surgical aortic valve replacement (SAVR) or are at high surgical risk. Recently, increased operator experience and improved device systems have led to a worldwide trend toward the extension of TAVI to low-risk or intermediate-risk patients...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29561311/cardiac-magnetic-resonance-imaging-and-primary-prevention-implantable-cardioverter-defibrillator-therapy-current-recommendations-and-future-directions
#17
Andrea I Guaricci, Delia De Santis, Mark G Rabbat, Gianluca Pontone
: Implantable cardioverter defibrillators (ICDs) have proven to be the most effective preventive therapy of sudden cardiac death (SCD). Based on current guidelines, the indication for prophylactic ICD therapy is primarily based on a left ventricular ejection fraction (LVEF) less than 35%. However, patients with low LVEF may never have an arrhythmic event while patients with normal to moderately reduced LVEF, who are traditionally felt to be at lower risk, can experience SCD. Therefore, LVEF alone is not an ideal risk stratification parameter to determine ICD therapy...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29528869/cardio-oncology-organization-patterns-in-italy-one-size-does-not-fit-all
#18
Maria Laura Canale, Chiara Lestuzzi, Irma Bisceglia, Paola Vallerio, Iris Parrini
AIMS: Cardio-oncology is imposing as the specialty deputed to the management of a large and rapidly increasing population of cancer patients receiving anticancer treatments with cardiovascular side effects or presenting with cardiac and oncological comorbidities. Organization patterns dramatically vary across Italy. METHODS: On the behalf of ANMCO, we have analyzed the characteristics of cardio-oncology services across different hospital types in Italy. A questionnaire was sent out to all ANMCO divisions inquiring about inner organization, workload, multidisciplinary team and inter-hospital connections...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29528868/pretreatment-with-p2y12-inhibitors-and-outcome-in-patients-with-st-segment-elevation-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#19
Olivier Gach, Astrid Nyssen, Charles Pirlet, Julien Magne, Cécile Oury, Patrizio Lancellotti
AIMS: Preload with clopidogrel, ticagrelor, or prasugrel in the setting of ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) is frequently applied. Limited data are available regarding the outcome impact of pretreatment with these drugs in the real world. METHODS AND RESULTS: The outcome of 760 STEMI patients treated by primary PCI receiving clopidogrel, prasugrel, or ticagrelor (n = 269, 327, 164, respectively) was evaluated...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29517516/hybrid-coronary-revascularization-versus-percutaneous-strategies-in-left-main-stenosis-a-propensity-match-study
#20
Alberto Repossini, Lorenzo Di Bacco, Fabrizio Rosati, Maurizio Tespili, Antonio Saino, Alfonso Ielasi, Claudio Muneretto
AIMS: Hybrid revascularization (HCR) has been recently proposed as an alternative strategy in multivessel coronary disease, particularly in patients with high SYNTAX scores and risk scores. The objective of this study is to evaluate the outcomes of HCR versus percutaneous coronary intervention (PCI) drug-eluting stenting in left main treatment. METHODS: A series of 198 consecutive patients with left main stenosis have been treated. HCR, was performed in 77 patients (G1) whereas 121 patients (G2) received PCI on left main...
May 2018: Journal of Cardiovascular Medicine
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