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Journal of Cardiovascular Medicine

Susanna Sciomer, Federica Moscucci, Christian Cadeddu Dessalvi, Martino Deidda, Giuseppe Mercuro
: Despite cardiovascular disease (CVD) is now the leading cause of morbidity and mortality in women worldwide, this problem is still dramatically underestimated. The disparities in diagnosis, treatment, and prognosis between men and women are rooted in basic biological differences, as well as in the complex interactions of cultural and socioeconomic problems. This is why an up-to-date and gender-based revision of current guidelines is highly desirable.
September 18, 2018: Journal of Cardiovascular Medicine
Maurizio Cusmà-Piccione, Luca Longobardo, Alessandra Oteri, Roberta Manganaro, Gianluca Di Bella, Scipione Carerj, Bijoy K Khandheria, Concetta Zito
: Takotsubo cardiomyopathy (TTS), also known as left ventricular apical ballooning syndrome, is an acute, usually reversible heart failure syndrome that most often affects postmenopausal women experiencing an emotionally stressful event. It is characterized by sudden left ventricular dysfunction and wall motion abnormalities involving the apical and mid segments. TTS has been increasingly recognized in recent years, and more and more information about the pathophysiology, diagnosis, and treatment of these patients has been reported...
September 17, 2018: Journal of Cardiovascular Medicine
Anna Balducci, Tammam Hasan, Andrea Donti, Gabriele Egidy Assenza, Luigi Lovato, Marianna Fabi, Valentina Gesuete, Daniela Prandstraller, Roberto Formigari, Luca Ragni, Emanuela Angeli, Gaetano D Gargiulo, Fernando M Picchio, Marco Bonvicini
BACKGROUND: Proper integration of multiple imaging modalities in the routine follow-up of patients with repaired tetralogy of Fallout (TOF) is poorly supported by data. We report our single center comparative study between cardiac magnetic resonance (CMR) and echocardiography to assess equipoise in the clinical utility of these two imaging methods in an unselected consecutive cohort of TOF patients referred to our outpatient clinic. MATERIAL AND METHODS: In this cross-sectional study, repaired TOF patients who underwent CMR and echocardiography within a 4-week period between 2010 and 2011 at our Center were included...
September 17, 2018: Journal of Cardiovascular Medicine
Marco Pocar, Flavio Airoldi, Davide Tavano
CONTEXT: Associations between cocaine use and coronary heart disease are widely reported. Their impact on the progression of atherosclerotic lesions is poorly defined. CLINICAL CASE: A previously asymptomatic 41-year-old man with no cardiovascular risk factor presented with acute non-ST elevation myocardial infarction evolving into cardiogenic shock. Angiography revealed diffuse coronary lesions and triple-vessel chronic total occlusions with wide collaterals. Revascularization was accomplished with multiple interventions and extracorporeal membrane oxygenation was necessary for circulatory support...
September 17, 2018: Journal of Cardiovascular Medicine
Marco Ferlini, Roberto Dore, Gianmarco Iannopollo, Gaetano M De Ferrari, Luigi Oltrona Visconti
: A 54-year-old woman with a history of stage IV nonsmall-cell lung cancer, on treatment with chemiotherapy was hospitalized for acute coronary syndrome. Coronary angiography showed a tight stenosis of ostial left main coronary artery (LMCA) probably caused by external compression. Computed tomography scan confirmed LMCA compression and entrapment between a neoplastic mass and the root of the aorta, with vessel collapsing during diastole but patency and narrowing in systole. A drug-eluting stent was then successfully implanted at LMCA ostium without further episodes of angina...
September 17, 2018: Journal of Cardiovascular Medicine
Anna Vittoria Mattioli, Francesca Coppi, Mario Migaldi, Alberto Farinetti
: Physical activity is considered very useful in the prevention of cardiovascular disease. The present study aims to evaluate the role of physical activity in women with high adherence to a Mediterranean diet and its correlation with asymptomatic atherosclerosis. A group of 425 premenopausal women (mean age 48 ± 9 years) was evaluated. They completed the International Physical Activity Questionnaire (IPAQ) developed by the World Health Organization, validated for the Italian population, to assess the degree of physical activity participation...
September 14, 2018: Journal of Cardiovascular Medicine
Qian Liu, Yuanyuan Wang, Xiucui Cheng
OBJECTIVE: To investigate the effect of different doses of atorvastatin on patients with acute ST segment elevation myocardial infarction (MI) after emergency percutaneous coronary intervention (PCI). METHODS: A total of 265 patients with acute ST segment elevation MI who underwent emergency PCI were enrolled, 133 in high-dose atorvastatin administration (40 mg/day) and 132 in moderate-dose atorvastatin administration (20 mg/day). All the patients continued treatment for 1 year...
September 14, 2018: Journal of Cardiovascular Medicine
Federico Migliore, Francesco Pelliccia, Camillo Autore, Emanuele Bertaglia, Franco Cecchi, Antonio Curcio, Luca Bontempi, Antonio Curnis, Paolo De Filippo, Antonio D'Onofrio, Pietro Francia, Niccolò Maurizi, Beatrice Musumeci, Alessandro Proclemer, Alessandro Zorzi, Domenico Corrado
: Cardiomyopathies and channelopathies are heterogeneous disorders that increase the risk of sudden cardiac death (SCD). Implantable cardioverter-defibrillator (ICD) therapy is safe and effective for preventing SCD in patients at risk for malignant ventricular arrhythmias. Because of the poor positive predictive value of current risk stratification tools, the majority of patients implanted with an ICD will never receive a life-saving therapy but will be exposed to the risk of complications such as device infection, lead failure and inappropriate therapy...
September 14, 2018: Journal of Cardiovascular Medicine
Elisabetta Dinatolo, Nicolò Dasseni, Marco Metra, Carlo Lombardi, Stephan von Haehling
: Due to aging of the patients with heart failure, comorbidities are an emerging problem and, among them, iron deficiency is an important therapeutic target, independently of concomitant hemoglobin level. Iron deficiency affects up to 50% of heart failure patients, and it has been largely established its association with poor quality of life, impaired exercise tolerance and higher mortality. Randomized controlled trials (RCTs) and meta-analyses have demonstrated that intravenous iron supplementation in heart failure patients with iron deficiency positively affects symptoms, quality of life, exercise tolerance (as measured by VO2 peak and 6MWT), with a global trend to reduction of hospitalization rates...
September 14, 2018: Journal of Cardiovascular Medicine
Pierluigi Omedè, Maurizio Bertaina, Enrico Cerrato, Lolo Rubio, Ivan Nuñez-Gil, Sebastiano Gili, Salma Taha, Carlos Macaya, Javier Escaned, Fabrizio D'Ascenzo
BACKGROUND: Safety and efficacy of radial and femoral access for coronary angiography performed by cardiology fellows remain to be evaluated. METHODS: In this multicenter prospective study, cardiology fellows selected the access site (among femoral, right and left radial artery) for coronary angiography. All bleeding events related to the access site and all complications (a composite of all bleedings and artery occlusion) were the co-primary safety end points. Success for each access site, procedural and radiological times and single components of primary outcome were the secondary ones...
September 14, 2018: Journal of Cardiovascular Medicine
Valentina Mercurio, Alberto Palazzuoli, Michele Correale, Carlo Lombardi, Andrea Passantino, Alice Ravera, Gaetano Ruocco, Edoardo Sciatti, Marco Triggiani, Rocco Lagioia, Domenico Scrutinio, Carlo G Tocchetti, Savina Nodari
: The right ventricle has become increasingly studied in cardiovascular research. In this article, we describe specific pathophysiological characteristics of the right ventricle, with special focus on functional and molecular modifications as well as therapeutic strategies in right ventricular dysfunction, underlining the differences with the left ventricle. Then we analyze the main imaging modalities to assess right ventricular function in different clinical settings. Finally, we acknowledge main therapeutic advances for treatment of right heart diseases...
July 25, 2018: Journal of Cardiovascular Medicine
Valerio Zacà
AIMS: The availability of novel drugs might affect the modern interplay between pharmacological and device therapy of heart failure with reduced ejection fraction (HFrEF). The aim of this study was to assess the cost-effectiveness of sacubitril/valsartan as compared with an implantable cardioverter-defibrillator (ICD) on top of optimal medical therapy in patients with HFrEF. METHODS: Data from 2000 adults with demographic and clinical characteristics similar to those in the PARADIGM-HF were derived as inputs for a four-state Markov model simulated HFrEF...
October 2018: Journal of Cardiovascular Medicine
Marcello Marino, Michele Cacucci, Antonio Catanoso, Andrea Demarchi, Roberto Dore, Maurizio Landolina
No abstract text is available yet for this article.
October 2018: Journal of Cardiovascular Medicine
Joren Maeremans, Daan Cottens, Lorenzo Azzalini, Bruno Pereira, Cosmo Godino, Mauro Carlino, Antonio Colombo, Peter Frambach, Barbara Bellini, Luciano Candilio, Carlo Briguori, Adele Pierri, Scott Lamers, Lien Roux, Jolien Duponselle, Mathias Vrolix, Jo Dens
AIMS: Late stent thrombosis and delayed vessel wall healing remain an important issue in coronary vessels treated with drug-eluting stents (DES), especially when long-vessel segments need to be covered, like in chronic total occlusions (CTO). Avoiding polymer use to avoid chronic inflammatory responses is a potential solution to reduce target vessel failure (TVF). We aimed to validate the clinical safety and efficacy at 1 year of the polymer-free Cre8 DES vs. nonpolymer-free DES for the percutaneous treatment of CTO...
October 2018: Journal of Cardiovascular Medicine
Cosimo Carriere, Davide Stolfo, Valeria Baglio, Riccardo Gerloni, Marco Merlo, Giulia Barbati, Antonio Cannatà, Gianni Biolo, Gianfranco Sinagra
BACKGROUND: The multidimensional prognostic index (MPI) is a validated tool for prognostic stratification in acute and chronic setting of geriatric patients. However, only few data are available on patients with cardiovascular diseases. AIM: To evaluate the potential role of MPI as predictor of 1-year and long-term outcome in ultra-octogenarians patients hospitalized for cardiovascular diseases. METHODS AND RESULTS: We conducted a prospective study on 216 patients (mean age 85 ± 4 years) hospitalized for cardiovascular disease enrolled from September 2011 to February 2014 in both Cardiology and Internal Medicine Departments...
October 2018: Journal of Cardiovascular Medicine
Giuseppe Berton, Rocco Cordiano, Fiorella Cavuto, Francesco Bagato, Beatrice Segafredo, Mattia Pasquinucci
AIM: To investigate the clinical features and incidence of malignant neoplasia during 17 years of follow-up in an unselected sample of patients with acute coronary syndrome (ACS). METHODS: The Adria, Bassano, Conegliano, and Padova Hospital-4 Study on Heart Disease is an ongoing, prospective study of an unbiased population of patients with ACS. Baseline clinical and laboratory data were obtained during the first 7 days of hospitalization at three different intensive coronary care units...
October 2018: Journal of Cardiovascular Medicine
Maurizio Bertaina, Ovidio De Filippo, Mario Iannaccone, Antonio Colombo, Gregg Stone, Patrick Serruys, Massimo Mancone, Pierluigi Omedè, Federico Conrotto, Mauro Pennone, Takeshi Kimura, Hiroyoshi Kawamoto, Giuseppe Biondi Zoccai, Imad Sheiban, Christian Templin, Umberto Benedetto, Rafael Cavalcante, Maurizio D'Amico, Mario Gaudino, Claudio Moretti, Fiorenzo Gaita, Fabrizio D'Ascenzo
BACKGROUND: Treatment of patients with ULMCA (unprotected left main coronary artery disease) with percutaneous coronary intervention (PCI) has been compared with coronary artery bypass graft (CABG), without conclusive results. METHODS: All randomized controlled trials (RCTs) and observational studies with multivariate analysis comparing PCI and CABG for ULMCA were included. Major cardiovascular events (MACEs, composite of all-cause death, MI, definite or probable ST, target vessel revascularization and stroke) were the primary end points, whereas its single components were the secondary ones, along with stent thrombosis, graft occlusion and in-hospital death and stroke...
October 2018: Journal of Cardiovascular Medicine
Mario Iannaccone, Gaëlle Saint-Hilary, Davide Menardi, Paolo Vadalà, Alessandro Bernardi, Matteo Bianco, Antonio Montefusco, Pierluigi Omedè, Salvatore D'Amico, Fabio Piazza, Paolo Scacciatella, Maurizio D'Amico, Claudio Moretti, Giuseppe Biondi-Zoccai, Mauro Gasparini, Fiorenzo Gaita, Fabrizio D'Ascenzo
INTRODUCTION: Different devices have been released for closure of femoral vascular access after coronary angiography or percutaneous coronary intervention, whereas evidence about their efficacy and safety when compared with manual compression or head to head is lacking, especially across different diameters of sheaths, age and sex. RESULTS: A total of 30 studies were included in the analysis. Manual compression was evaluated as the control group in all of the included studies (5620 patients), Angioseal in 15 studies (17-29) (1812 patients), Exoseal in two studies (30-31) (1773 patients), Perclose in six (29, 32-37) (849 patients), Vasoseal in eight (36, 38-43) (699 patients), DUETT in one study (44) (392 patients), StarClose in two studies (23, 45) (334 patients), Techstar in two studies (37, 46) (252 patients) and extravascular staple in one study (47) (242 patients)...
October 2018: Journal of Cardiovascular Medicine
Luigi Biasco, Giovanni Pedrazzini, Ole De Backer, Catherine Klersy, Luca Bellesi, Stefano Presilla, Matteo Badini, Francesco Faletra, Elena Pasotti, Enrico Ferrari, Stefanos Demertzis, Tiziano Moccetti, Davide Aviano, Marco Moccetti
BACKGROUND: Radiological exposure associated with transcatheter aortic valve implantation (TAVI) is unknown and might impact on broadening indications to lower risk patients. Radiological exposure of TAVI patients and its predictors are herein reported. METHODS: Radiological exposure derived from exams/procedures performed within 30 days preceding/following TAVI were acquired and converted into effective-dose. Total effective-dose was defined as the sum of each single dose derived from diagnostic/therapeutic sources...
October 2018: Journal of Cardiovascular Medicine
Antonio Cannata', Marco Merlo, Jessica Artico, Piero Gentile, Luca Camparini, Jacopo Cristallini, Aldostefano Porcari, Francesco Loffredo, Gianfranco Sinagra
: The rapid increase in the median age of the world's population requires particular attention towards older and more fragile people. Cardiovascular risk factors, time and comorbidities play a vicious role in the development of heart failure, both with reduced and preserved ejection fraction, in the elderly. Understanding the mechanisms underlying the pathophysiological processes observed with aging is pivotal to target those patients and their therapeutic needs properly. This review aims to investigate and to dissect the main pathways leading to the aging cardiomyopathy, helping to understand the relationship from bench to bedside of the clinical phenotype...
October 2018: Journal of Cardiovascular Medicine
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