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Hellenic Journal of Nuclear Medicine

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https://www.readbyqxmd.com/read/28777833/the-effect-of-scatter-correction-on-planar-and-tomographic-semiquantitative-123-i-cardiac-imaging-a-phantom-study
#1
Emmanouil Papanastasiou, Efstratios Moralidis, Anastasios Siountas
OBJECTIVE: In cardiac I-123 ((123)I) imaging downscatter from high energy emissions degrades the image and introduces distortion of semi-quantitative analysis when using a low energy collimator. The effect of a triple energy window (TEW) scatter correction technique, using windows immediately above and below the principal window centered on 159keV, was examined. MATERIALS AND METHODS: A hemispherical cardiac phantom was inserted into a cylindrical phantom and both were filled with radioactive (123)I water solutions...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28777832/endless-research-ii-the-genomic-era-neohippocratic-medicine
#2
EDITORIAL
Philip C Grammaticos, Dimitrios E Antoniou
The great progress of genetics research, during 2015-2017, will certainly influence all medical specialties including nuclear medicine. In nuclear medicine there are still problems to solve as to differentiate between infection, inflammation and cancer etc. Furthermore, in dosimetry and radiation protection there are worldwide problems. It has been reported that (64) Cu-cetuximab immune-PET represented EGFR expression levels in ESCC tumors and that (177) Lu-cetuximab radioimmunotherapy effectively inhibited the tumor growth...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697199/negative-18-f-fdg-pet-and-positive-ct-and-mri-findings-in-multifocal-splenic-hamartoma
#3
Christophe Van de Wiele, Koenraad Verstraete, Sophie Bourgeois, Alex Maes
We report our fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FFDG PET/CT) findings in a 51 years old female presenting with B symptoms, respectively fever, night sweats and malaise, that underwent an (18)F-FDG PET/CT examination to exclude underlying lymphomatous disease. Whereas (18)F-FDG PET scan findings were negative, CT put to evidence the presence of multiple small lesions suggestive for multifocal hamartoma. On a subsequently performed magnetic resonance imaging (MRI) of the spleen, multiple infracentimetric foci were visualized displaying characteristic findings for hamartoma...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697198/unusual-diffuse-liver-18-f-fdg-uptake-in-melanoma-patient-treated-by-ipilimumab
#4
Muteganya Raoul, Karfis Ioannis, Artigas Carlos, Garcia Camilo, Francesco Feoli, Kerger Joseph, Flamen Patrick
We present herein a case of unusual (18)F-FDG PET-CT diffuse hypermetabolic liver uptake in melanoma patient treated by ipilimumab.
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697197/increased-and-normalized-uptake-of-18-f-fdg-in-a-case-of-bone-periprosthetic-infection-treated-by-antibiotics
#5
Valentina Lavelli, Cristina Ferrari, Artor Niccoli Asabella, Corinna Altini, Francesco Saverio Vella, Giuseppe Rubini
We report the case of a 69 years old man with left hip prosthesis, who presented clinical, biochemical and imaging signs of periprosthetic infection treated with linezolid, an antibacterial agent of the oxazolidinone class. Two weeks after this treatment, a fluorine-18-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan showed increased uptake in the skeleton and also increased uptake in several focal areas in the spine and near the prosthesis and the surgical wound on the left gluteus medius...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697196/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-findings-in-a-pediatric-mucoepidermoid-carcinoma-and-differential-diagnosis
#6
Jianhao Xie, Chao Ma, Jun Tang
An 11 years old boy was referred to our hospital. He complained for the last three months for intermittent cough and shortness of breath after exercise which worsened recently. Airways computed tomography (CT) showed an abnormal endobronchial tumor, obstructing the right main bronchus and also atelectasis in the upper lobe of the right lung. Bronchoscopy showed a wet on its surface mass obstructing the right main bronchus. Biopsy showed a mucoepidermoid carcinoma (MEC). The fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan showed in the same area a mass with slightly increased (18)F-FDG uptake (maximum standardized uptake value, SUVmax: 3...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697195/fluorine-18-fdg-pet-ct-in-a-patient-with-angiomyolipoma-response-to-mammalian-target-of-rapamycin-inhibitor-therapy
#7
Hoda Anwar, Christos Sachpekidis, Matthias Schwarzbach, Antonia Dimitrakopoulou-Strauss
We report on a 27 years old female patient who was referred to our department for whole-body as well as dynamic positron emission tomography/computed tomography (dPET/CT) scan of the upper and middle abdomen with fluorine-18-fluorodeoxy glucose ((18)F-FDG), for further evaluation of a mass in the left adrenal gland region. Positron emission tomography showed a suspicious, enlarged, hypermetabolic mass with an average standardized uptake value (SUV) of 4.5 and a maximum SUV of 5.9. The patient was referred for biopsy, which revealed an angiomyolipoma, a perivascular epithelioid cell tumor (PEComa) of the adrenal gland...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697194/enhancing-contrast-agents-and-radiotracers-performance-through-hyaluronic-acid-coating-in-neuroradiology-and-nuclear-medicine
#8
Mario Ganau, Nikolaos Ch Syrmos, Felice D'Arco, Laura Ganau, Salvatore Chibbaro, Lara Prisco, Gianfranco K I Ligarotti, Rossano Ambu, Andrea Soddu
The use of hyaluronic acid nanoshells has been proposed to encapsulate prodrugs and exploit the mechanisms of interactions between living cells, like endocytes or cancer cells and hyaluronic acid, which is a natural component of the extracellular matrix. In this review we describe the potential and the limits of this promising research trend and discuss the theoretical advantages of such an engineering approach. Is it a possible scalability to increase the efficacy and biodegradability of molecules like contrast media and radiotracers especially for neuroradiology and nuclear medicine studies...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697193/the-value-of-18-fdg-pet-ct-parameters-hematological-parameters-and-tumor-markers-in-predicting-kras-oncogene-mutation-in-colorectal-cancer
#9
Ali Ozan Oner, Evrim Surer Budak, Senay Yıldırım, Funda Aydın, Cem Sezer
OBJECTIVE: In this study we investigated the predictive value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), neutrophils/lymphocytes ratio (NLR), platelets/lymphocytes ratio (PLR), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the prediction of KRAS gene mutation which plays an important role in the choice of treatment in colorectal cancer patients. SUBJECTS AND METHODS: A total of 55 cases with untreated colorectal cancer who had undergone both PET/CT examinations for initial staging and also mutation analysis of KRAS oncogene were studied...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697192/a-prototype-pet-spect-x-rays-scanner-dedicated-for-whole-body-small-animal-studies
#10
Maritina Rouchota, Maria Georgiou, Eleftherios Fysikopoulos, Eirini Fragogeorgi, Konstantinos Mikropoulos, Panagiotis Papadimitroulas, George Kagadis, George Loudos
OBJECTIVE: To present a prototype tri-modal imaging system, consisting of a single photon emission computed tomography (SPET), a positron emission tomography (PET), and a computed tomography (CT) subsystem, evaluated in planar mode. MATERIALS AND METHODS: The subsystems are mounted on a rotating gantry, so as to be able to allow tomographic imaging in the future. The system, designed and constructed by our group, allows whole body mouse imaging of competent performance and is currently, to the best of our knowledge, unequaled in a national and regional level...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697191/an-innovative-method-for-precise-lymph-node-detection-before-surgical-treatment-in-breast-cancer
#11
Milovan Matovic, Dalibor Nikolic, Nenad Filipovic, Dongfang Chen, Marija Jeremic, Slobodan M Jankovic, Srdjan Ninkovic, Aleksandar Cvetkovic, Marina Vlajkovic, Ana Rankovic
OBJECTIVE: To describe a new method of 3D interactive modeling which integrates images obtained by separate SPET and multi slice computed tomography (MSCT) modalities using an original software in order to better localize SNL in BC patients. SUBJECTS AND METHODS: We used technetium-99m-colloid rhenium sulphate for identifying SNL in seven patients with BC. Markers were made of lead pearls wrapped with cotton wool soaked in (99m)Tc-pertechnetate and placed on the skin of the patients forming of a triangle...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697190/-18-f-fdg-pet-ct-and-histology-for-diagnosing-recurrent-remnant-tumors-in-head-and-neck-cancer-patients-treated-with-radiotherapy
#12
Eun Ji Han, Joo Hyun O, Ie Ryung Yoo, Yeon Sil Kim, Min Sik Kim, Jin Hyoung Kang, Woo Hee Choi
OBJECTIVE: The aim of this study was to assess the diagnostic performance of fluorine-18-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) for locoregional recurrent/residual tumor in patients with head and neck cancer (HNC) who underwent previous radiotherapy (RT). SUBJECTS AND METHODS: (18)F-FDG PET/CT images from patients with HNC who previously underwent RT were retrospectively reviewed. Only cases with histological confirmation within 4 weeks of PET/CT imaging were included...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697189/gallium-68-dotatate-pet-ct-is-better-than-ct-in-the-management-of-somatostatin-expressing-tumors-first-experience-in-africa
#13
Ismaheel O Lawal, Kehinde O Ololade, Thabo Lengana, Florette Reyneke, Alfred O Ankrah, Thomas Ebenhan, Mariza Vorster, Mike M Sathekge
OBJECTIVE: In this study we aimed to present our experience on the use of Gallium-68-dotatate with positron emission tomography, computed tomography ((68) Ga-dotatate PET/CT) in the management of neuroendocrine tumors (NET) and other somatostatin expressing tumors. SUBJECTS AND METHODS: We retrospectively reviewed patients with histologically confirmed or biochemically suspected NET and other somatostatin expressing (SSTR) tumors imaged at our department with (68)Ga-dotatate PET/CT...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697188/impact-of-tall-cell-variant-histology-on-predicting-relapse-and-changing-the-management-of-papillary-thyroid-carcinoma-patients
#14
Bengul Gunalp, Kursat Okuyucu, Semra Ince, Aslı Ayan, Engin Alagoz
OBJECTIVE: There has been much discussion recently about the risk category of tall cell variant (TVC) histology and its effects on the management of papillary thyroid carcinoma (PTC). We, therefore, undertook a retrospective study to compare stage-matched risk factors and recurrence rates between classical PTC (cPTC) patients and patients with TCV histology. SUBJECTS AND METHODS: A total of 3128 well-differentiated thyroid carcinoma patients who were treated and followed-up for more than 5 years in our clinic from 1995 to 2016 were included in this study...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697187/can-semiquantitative-measurements-of-suvmax-and-cut-off-values-differentiate-colorectal-malignant-from-benign-lessions
#15
Tram Nguyen, Søren Hess, Henrik Petersen, Abass Alavi, Poul Flemming Høilund-Carlsen
OBJECTIVE: We investigated maximum standardized uptake value (SUVmax) and cut-off values for differentiation of malignant and benign lesions in colorectal cancer (CC) as multiple studies have questioned their validity. We also investigated more extended indices using common semi-quantification analysis in incidental colorectal findings (ICF). SUBJECTS AND METHODS: Fluorine-18-fluoro deoxy glucose positron emission tomography/computed tomography in 25 patients with a total of 30 focal ICF was retrospectively analysed using dedicated software...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28697186/whiplash-syndrome-a-disorder-of-the-brain
#16
EDITORIAL
Jennifer Biendara, Andreas Otte
In the past two decades much has been published on whiplash injury, yet both the confusion regarding the condition, and the medicolegal discussion about it have increased. In this paper, functional imaging research results are summarized using MRIcroGL 3D visualization software and assembled in an image comprising regions of cerebral activation and deactivation.
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28426840/multimodality-multiparametric-brain-tumors-evaluation
#17
REVIEW
Vasiliki Tsitsia, Patricia Svolou, Eftichia Kapsalaki, Kyriaki Theodorou, Katerina Vassiou, Varvara Valotassiou, Panagiotis Georgoulias, Ioannis Fezoulidis, Ioannis Tsougos
Brain tumors represent a vast group of lesions, originating from different neuronal cells with different degrees of aggressiveness. Despite some technological advances either pre or post-treatment, these tumors may share similar imaging findings and properties, rendering diagnosis/prognosis, an ambiguous process. Gadolinium-enhanced magnetic resonance imaging remains the gold standard for providing detailed morphologic information, but presents several limitations due to the overlap of findings, in cases such as progressive tumor and post-radiation related effects...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28426839/medical-history-in-the-hellenic-journal-of-nuclear-medicine
#18
EDITORIAL
Andreas Otte
The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315919/a-rare-adult-renal-neuroblastoma-better-imaged-by-18-f-fdg-than-by-68-ga-dotanoc-in-the-pet-ct-scan
#19
COMPARATIVE STUDY
Tarun Kumar Jain, Sharwan Kumar Singh, Ashwani Sood, Abhiram Gj Ashwathanarayama, Rajender Kumar Basher, Jaya Shukla, Bhagwant Rai Mittal
Primary renal neuroblastoma is an uncommon tumor in children and extremely rare in adults. We present a case of a middle aged female having a large retroperitoneal mass involving the right kidney with features of neuroblastoma on pre-operative histopathology. Whole-body fluorine-18-fluoro-deoxyglucose positron emission tomography ((18)F-FDG PET/CT) and (68)Ga-dotanoc PET/CT scans performed for staging and therapeutic potential revealed a tracer avid mass replacing the right kidney and also pelvic lymph nodes...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315918/fluorrine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-of-adult-liver-langerhans-cell-histiocytosis
#20
Hengshan Ji, Jiang Wu, Guifen Yang, Chuanjin Sun, Hong Zhu, Longjiang Zhang
OBJECTIVE: Adult liver Langerhans cell histiocytosis (LCH) is an extremely rare desease. This paper reports a 40 years old male patient who was diagnosed as liver LCH though ultrasound-guided liver biopsy. The initial Fluorrine-18- fluorodeoxyglucose positron emission tomography/ computed tomography ((18)F-FDG PET/CT) showed multiple nodular low-density lesions in liver without obvious elevated (18)F-FDG uptake. Four years later, the follow-up (18)F-FDG PET/CT showed the liver multiple lesions with slightly elevated (18)F-FDG uptake...
January 2017: Hellenic Journal of Nuclear Medicine
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