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Hellenic Journal of Nuclear Medicine

P Cegla, E Wierzchoslawska, A Marszalek, S Gwozdz, W Cholewinski
Hodgkin's lymphoma and lung adenocarcinoma as second primary cancers in prostate cancer (PC) patients although are rare should be considered as important for the future of the PC patients.
November 10, 2018: Hellenic Journal of Nuclear Medicine
Yuxiao Xia, Nikitas Papadopoulos, Yue Chen, Yanhong Zhao
Osteoarticular tuberculosis (OAT) is not uncommon in children. Early diagnosis and treatment are essential to avoid ultimately long-term disabilities. Nicolas Andry (1658-1742) gave for the first time the name of the specialty of Orthopedics (L'Orthopedie) and its symbol of the crooked tree, in a paper in which he suggested how to avoid and to treat rachitis in children. We review the correlative-imaging findings and provide insights regarding the strengths and limitations of the conventional imaging modalities and those of nuclear medicine for the diagnosis of OAT and its differential diagnosis from other diseases...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Christian Kratzik, Susanne Dorudi, Marina Schatzl, Helmut Sinzinger
OBJECTIVE: The introduction of the prostate specific membrane antigen (PSMA) offers the possibility to discover prostate cancer recurrences being frequently so small that they cannot be detected by conventional imaging modalities, such as magnetic resonance or computed tomography. SUBJECTS AND METHODS: A 78 years old patient after radical prostatectomy and lymphadenectomy suffered from recurrence of the disease and galium-68-PSMA (68 Ga-PSMA) showed a single hot spot...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Mario Ganau, Vishal Prasad, Gianfranco K I Ligarotti, Nikolaos Ch Syrmos, Habib Ellamushi
OBJECTIVE: Gorham-Stout disease (GSD), commonly referred as vanishing bone or phantom bone disease, is a rare disorder characterized by spontaneous bone osteolysis due to proliferation of lymphangiomatous tissue. This disease can involve multiple bones and cause pathologic fractures. The exact cause of GSD is unknown and its severity is unpredictable; the disorder can potentially cause disfigurement or functional disability. According to CARE guidelines, we studied a 46 years old lady with a progressive defect of the skull...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Artor Niccoli Asabella, Alessandra Di Palo, Corinna Altini, Margherita Fanelli, Cristina Ferrari, Valentina Lavelli, Girolamo Ranieri, Cosmo D Gadaleta, Giuseppe Rubini
OBJECTIVE: To evaluate the role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in therapy response assessment according modified response evaluating criteria of solid tumors (mRECIST) and the predictive role of volume-based semi-quantitative parameters in patients with malignant pleural mesothelioma (MPM). Furthermore modified RECIST criteria for MPM mRECIST and the European Organization for Research and Treatment of Cancer (EORTC) criteria were compared and the predictive role of 18 F-FDG PET/CT in the post-therapy outcome...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Dani P Yellanki, Esha Kothekar, Abdullah Al-Zaghal, Nina Cheng, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: Osteoarthritis (OA) is characterized by synovial tissue inflammation and underlying bone degeneration in the joints. Aging and obesity are among the major risk factors. This study evaluated the effects of aging and body mass index (BMI) on hip joint inflammation and bone degeneration using fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) and fluorine-18 sodium fluoride (18 F-NaF) PET/CT imaging, respectively. SUBJECTS AND METHODS: In this retrospective study, a total of 116 subjects (58 males and 58 females) who had undergone both 18 F-FDG and 18 F-NaF PET/CT imaging were analyzed...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Sara Pourhassan Shamchi, Mohsen Khosravi, Raheleh Taghvaei, Mahdi Zirakchian Zadeh, Koosha Paydary, Sahra Emamzadehfard, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: Normal aging alters the brain function even in the absence of recognizable structural changes, which can be detected using modern in vivo functional imaging modalities such as fluorine-18 fluorodeoxyglucose positron emission tomography (18 F-FDG PET) scan. It is highly important to recognize normal age-dependent changes in order to correctly diagnose pathologic states. The goal of the current study was to evaluate the age-related changes in regional brain 18 F-FDG uptake in normal healthy population...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Gonca G Bural, Drew A Torigian, Melih Sözmen, Mohamed Houseni, Abass Alavi
OBJECTIVE: Subjects with end stage renal disease (ESRD) are exposed to increased morbidity and mortality due to cardiovascular events. The primary underlying mechanism has been suggested as accelerated atherosclerosis in these patients. Our aim was to compare the atherosclerotic inflammation and calcification in subjects with ESRD on hemodialysis to that in normal controls utilizing fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT)...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Zuzana Meckova, Lukas Lambert, Ivan Spicka, Jozef Kubinyi, Andrea Burgetova
Our limited experience suggests that fluorine-18-fluorocholine (18 F-FCH) may perform better in the detection of skeletal involvement by multiple myeloma compared to fluorine-18-fluorodeoxyglucose (18 F-FDG) and that standard uptake ratio (SUR) might be considered in the semi-quantitative comparison of tracer uptake.
November 10, 2018: Hellenic Journal of Nuclear Medicine
Christos Sachpekidis, Vasileios Sachpekidis, Efstratios Moralidis, Georgios Arsos
18 The non-invasive assessment of left ventricular function with simple indices, such as left ventricular volumes and ejection fraction (LVEF), offers significant diagnostic and prognostic implications in the entire spectrum of cardiac diseases. Equilibrium radionuclide ventriculography (RNV) is a well validated technique for this purpose. Based on the principle that the amount of radioactivity emitted by technetium-99m (99m Tc)-pertechnate labeled erythrocytes in the cardiac chambers is proportional to the amount of bloodcontained, reproducible and accurate LVEF measurements can be obtained, with practically no geometric assumptions regarding heart shape...
September 2018: Hellenic Journal of Nuclear Medicine
Ssang Tae Kim, Chul Soon Yong, Eun Ok Han
OBJECTIVE: Our aim was to identify the conditions required to stably maintain the radiochemical purity of fluorine-18-fluorodeoxyglucose (18 F-FDG) above the Korean Pharmacology (KP) and United States Pharmacology (USP) standards for expiration time (time from the end of synthesis (EOS), 8h even at a high radioactive concentration exceeding 7.4GBq/mL. SUBJECTS AND METHODS: The changes in the radiochemical purity of 18 F-FDG were assessed according to the changes in radioactive concentration, ethanol (EtOH) concentration, amount of water for dilution storage temperature, and storage volume...
September 2018: Hellenic Journal of Nuclear Medicine
Kemin Huang, Yanlin Feng, Dejun Liu, Wen Li, Weitang Liang, Lin Li
OBJECTIVE: Conventional Single-photon emission tomography (SPET) myocardial perfusion imaging (MPI) is performed in the supine position range RAO 45o -LPO 45o , but the effect of other acquisition arcs on imaging quality have not been well described. In this study, we compared the radioactivity over left ventricle walls as measured by different acquisition arcs to identify the best specific applications. SUBJECTS AND METHODS: A total of 125 low-risk coronary heart disease patients underwent technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI) stress MPI, of which 52 received 360o acquisition with reconstruction using different 180o projections and the remaining 73 received conventional 180o (LPO 45o -RAO 45o ) and left-side 180o (POST 180o -ANT 0o ) acquisition consecutively...
May 2018: Hellenic Journal of Nuclear Medicine
Eleni Mavriopoulou, Petros Zampakis, Evaggelia Smpiliri, Trifon Spyridonidis, Efthymia Rapti, Uwe Haberkorn, Thomas Makatsoris, Dimitrios J Apostolopoulos
OBJECTIVE: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field ("near" whole-body) SPET/CT application in breast cancer (BC) patients. SUBJECTS AND METHODS: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Whole body scan and SPET/CT were interpreted separately...
May 2018: Hellenic Journal of Nuclear Medicine
Kequan Lou, Yushen Gu, Yan Hu, Siyang Wang, Hongcheng Shi
OBJECTIVE: In this study we aimed to evaluate the role of technetium-99m pertechnetate whole body scan (99m Tc WBS) with single photon emission tomography/computed tomography (SPET/CT) in detecting remnant thyroid tissue, nodal and distant metastases, in differentiated thyroid cancer (DTC) patients before radioiodine (131 I) therapy. SUBJECTS AND METHODS: A retrospective analysis was performed in 416 pathologically confirmed DTC patients with total/near-total thyroidectomy...
May 2018: Hellenic Journal of Nuclear Medicine
Philip C Grammaticos, Elpida Emmanouil-Nikoloussie, Christos Trontzos, Aekaterini Kaidoglou, Chrysi Foroglou
Dear Editor, This rather original investigation was performed some time ago but is still unpublished. Its aim was to estimate the effect of low or high temperature cow's milk given to breast feeding rats in order to study possible influence of this diet to rats, to their physical growth and also esophageal mucosal pathology. Ten white female Wistar rats, 20 days of age were separated from their mothers and divided in 2 groups of 5 members each. Five of them were fed with milk kept at 42o C by using a special warming device...
May 2018: Hellenic Journal of Nuclear Medicine
Özlem Şahin, Pembe Oltulu
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis with lipid-laden macrophages and fibrosis. Although ECD is a multisystemic disease, the most common finding is sclerotic bone involvement in the diametaphyseal regions of bilateral distal femur and in proximal and distal tibia. We present a 40 years old woman who for the last two years had various systemic symptoms, especially knee pain, polyuria and polydipsia. Although a "hot knee" pattern was seen in bone scintigraphy (BS), a femur biopsy was performed, due to the preliminary diagnosis of haematologic malignancy...
May 2018: Hellenic Journal of Nuclear Medicine
Inneke Willekens, Stefaan J Vandecasteele, Kristof Verhoeven, Frank De Geeter
The use of hyaluronic acid nanoshells has been proposed to encapsulate prodrugs and exploit the mechanisms of interactions between living cells, like endocytes or cancer cells and hyaluronic acid, which is a natural component of the extracellular matrix. In this review we describe the potential and the limits of this promising research trend and discuss the theoretical advantages of such an engineering approach. Is it a possible scalability to increase the efficacy and biodegradability of molecules like contrast media and radiotracers especially for neuroradiology and nuclear medicine studies...
May 2018: Hellenic Journal of Nuclear Medicine
Chao Miao, Lei Zhang, Ming Sun, Chao Ma
A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99m Tc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI)...
May 2018: Hellenic Journal of Nuclear Medicine
Dalveer Singh, Roslyn Horneman, Navjot Kaur Nagra
OBJECTIVE: Prostate specific membrane antigen (PSMA) positron emission tomography diagnostic computed tomography (PET/CT) is gaining an increasing role in the staging of prostate cancer and restaging in cases of biochemical recurrence. Our understanding of PSMA affinity for incidental pathological and non-pathological entities is also maturing although certain cases do present as diagnostic and management dilemmas. SUBJECT AND METHODS: We present a case of a 55 years old man with prostate adenocarcinoma, with incidentally found pancreatic and thyroid lesions showing PSMA avidity...
May 2018: Hellenic Journal of Nuclear Medicine
Slobodanka Lj Beatović, Marija Radulović, Milica M Janković, Vera M Artiko, Boris Ajdinović, Dragana P Šobić-Šaranović
OBJECTIVE: The aim of this study was to assess the diagnostic ability of renal output efficiency (OE), normalized residual activity (NORA) and conventional interpretation of the diethylene triamine pentaacetic acid (99m Tc-DTPA) diuretic renogram (CIR) in diagnosing urine flow obstruction. SUBJECTS AND METHODS: Group A consisted of 73 obstructed kidneys and Group B of 80 kidneys with dilated upper urinary tract. Forty eight kidneys were examined as the control Group C...
May 2018: Hellenic Journal of Nuclear Medicine
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