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Hellenic Journal of Nuclear Medicine

Elias Mazokopakis, Maria Papadomanolaki, Spyridon-Nikitas N Skarakis, Konstantinos Tsekouras
The patients with Hashimoto thyroiditis must be investigated mainly for secondary hyperparathyroidism due to vitamin D deficiency/insufficiency. Parathyroid scintigraphy has no place in the diagnosis of primary, secondary or tertiary hyperparathyroidism or in the decision for surgical treatment. Parathyroid scintigraphy is a useful preoperative technique for the localization of the pathological parathyroid glands.
November 27, 2017: Hellenic Journal of Nuclear Medicine
Jing Lu, Qingquan Fang, Chao Ma, Fu Su, Guoqiang Chen, Meiling Huang, Weixing Wang, Xinhui Su
Diagnosis of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is challenging as its clinical presentation is atypical. Here we present a case of atypical EBV-HLH simulating lymphadenitis on fluorrine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), with a view to consider this kind of EBV-HLH as a possible differential diagnosis in lymphadenitis. A 68 years old male who had episodic fever accompanied by weight loss and weakness for two weeks was studied...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Christos Sachpekidis, Jessica C Hassel, Antonia Dimitrakopoulou-Strauss
Combination therapies for the treatment of metastatic melanoma are a matter of debate nowadays. We report on a stage IV metastatic melanoma patient with the BRAF V600 mutation and a large tumor burden initially treated with two cycles of ipilimumab. Due to dramatic disease progression, demonstrated on interim 18F-FDG PET/CT, vemurafenib was added in the patient's therapeutical scheme. After completion of the concurrent ipilimumab and vemurafenib administration, a third 18F-FDG PET/CT showed an impressive metabolic remission of the metastatic disease, reflecting the potential role of the modality in treatment response evaluation of melanoma patients receiving combination therapies...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Ling Yang, Jianfeng Wang, Yuetao Wang, Xiaoying Zhang
We studied a 50 years old male patient who underwent cardiac resynchronization therapy on and off (CRT-on and CRT-off) for assessment of left ventricular (LV) function and mechanical systole synchrony using gated myocardial perfusion imaging (gMPI) and real-time three-dimensional echocardiography (RT3DE). The patient was reexamined after seven months. The comparison of these two modalities showed consistent results on assessing both the CRT-on and CRT-off conditions. This result may indicate that an immediate synchronization parameter change during CRT-on may be valuable for predicting response to CRT surgery...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Mohsen Cheki, Hariprasad Gali
OBJECTIVE: In this study, we tried to estimate human absorbed dose of 68Ga-NODAGA-glycine as a new potential positron emission tomography (PET) renal agent based on the biodistribution data reported in healthy rats, and compare our estimation with the available absorbed dose data from technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA). SUBJECTS AND METHODS: The medical internal radiation dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Agata Pietrzak, Rafal Czepczynski, Ewa Wierzchoslawska, Witold Cholewinski
OBJECTIVE: The aim of this study was to compare the metabolic activity of metastatic foci from breast and prostate cancer patients as scanned by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and by technetium-99m methyl diphosphonate (99mTc-MDP) bone scan (BS). SUBJECTS AND METHODS: Forty one patients were studied, divided into 2 groups based on histologically confirmed diagnosis: a) Breast cancer group, 23 women, mean age: 61±12 years, range: 37-79 years and, b) Prostate cancer group, 18 men, mean age 68±8 years, range: 52-82 years...
November 27, 2017: Hellenic Journal of Nuclear Medicine
John Koutsikos, George Angelidis, Athanasios Zafeirakis, Ioannis Mamarelis, Merkourios Vogiatzis, Eliverta Ilia, Kyriakos Lazaridis, Nikolaos Demakopoulos
OBJECTIVE: MPI can provide valuable information in the investigation of patients with known or suspected coronary artery disease. The stress component of the studies can be conducted with regadenoson, which was approved for clinical use in Greece in 2016. We investigated the performance and safety profile of regadenoson MPI based on our 7 months institutional experience. PATIENTS AND METHODS: We studied 96 consecutive patients (59 males, 37 females, mean age 70...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Wei Lin Tay, Aaron Kian Ti Tong, Kei Yiu Douglas Hui, Yu Lin Charlene Tang, Chiaw Ling Chng
Radioactive iodine in the treatment of Graves' disease has been associated with the development of de novo Graves' ophthalmopathy (GO). In this report, we describe five individuals who required extensive ophthalmic treatment for post-RAI de novo GO.
November 27, 2017: Hellenic Journal of Nuclear Medicine
Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee, Jung Eun Oh, Yong Jin Cho, Hwang Sik Shin
OBJECTIVE: This study investigated whether fluorine-18-fluorodeoxyglucose (18F-FDG) uptake of reference organs can be affected by subjects' factors in positron emission tomography/computed tomography (PET/CT) in a healthy population. SUBJECTS AND METHODS: A total of 208 normal healthy subjects without diabetes or dyslipidemia were included. Adipose tissue volume was measured by CT images from a dedicated PET/CT scan. Uptake of 18F-FDG of reference organs was measured from liver, blood pool, and muscle, and was normalized by lean body anthropometric data and adipose tissue volume...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Gonca G Bural, Drew A Torigian, Mohamed Houseni, Kaan M Sözmen, Abass Alavi
OBJECTIVE: Fluorine-18 fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has a well-established role for detection and quantification of atherosclerotic inflammatory disease using standardized uptake value (SUV) measurements. Our aim was to compare the inflammatory and macroscopic calcification processes of atherosclerosis in the aortic segments and large arteries of subjects with insulin dependent diametes mellitus (IDDM) compared to those of age-matched controls via 18F-FDG PET/CT...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Hanna K Al-Makhamreh, Abedallatif A AlSharif, Mousa A Abujbara, Akram N Al-Ibraheem, Omar S Obeidat, Yazan I AlKawaleet, Aya Darawsheh, Mohammad I Liswi, Kamel M Ajlouni
OBJECTIVE: The aim of this study is to investigate whether gated single photo emission tomography (gSPET) can be used to detect subclinical left ventricular systolic dysfunction (LVSD) in obese diabetic type II patients. SUBJECTS AND METHODS: We retrospectively reviewed gSPET images of 190 patients with diabetes mellitus type II (DM II) (137 females and 53 males) with normal myocardial perfusion and normal ejection fraction (EF). Standardized twenty segment polar maps of thickening and motion were generated...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Yangchun Chen, Jincheng Huang, Yuehui Wang, Sipei Xie, Fang He
OBJECTIVE: The aim of this study was to evaluate the relative error (RE) in the thyroid absorbed dose (TD) of iodine-131 (131I) in patients with Graves' disease comparing the simplified Quimby-Marinelli-Hine formula method (sQMHF) and the Standard Operational Procedures for dosimetry (SOPD) recommended by the European Association of Nuclear Medicine. PATIENTS AND METHODS: This study included 45 patients with Graves' disease 12 men and 33 women; age 44.1±12.8 years...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Chunxia Qin, Xiaotian Xia, Zhijun Pei, Yongxue Zhang, Xiaoli Lan
OBJECTIVE: Reporter gene/probe systems have proved to be reliable for monitoring gene/cell therapy. We sought to evaluate whether a reporter gene/probe system, namely the human estrogen receptor ligand binding domain (hERL)/16α-18F fluoro-17β-estradiol (18F-FES), could be used for monitoring vascular endothelial growth factor (VEGF) gene expression and response to bone marrow mesenchymal stem cell (MSCs) therapy in ischemic heart disease. ANIMALS AND METHODS: Reporter gene hERL and therapeutic gene VEGF165 were linked through internal ribosome entry site (IRES), and then the recombinant adenovirus vector Adenovirus 5-hERL-IRES-VEGF (Ad5-EIV) was constructed and transfected into MSCs, and named Ad5-EIV-MSCs...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Mei Liu, Chunxia Qin, Xiaotian Xia, Mengting Li, Yichun Wang, Lijun Wang, Xiaoke Shang, Xiaoli Lan
OBJECTIVE: The study aimed to use myocardial perfusion imaging (MPI) as a semi-quantitative method to assess the clinical severity of pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD). SUBJECTS AND METHODS: A total of 24 patients with PAH related to CHD (PAH-CHD) who received interventional or medical treatment were included. All patients underwent physical examination, cardiac function evaluation, biochemical test, echocardiography, right heart catheterization (RHC), and MPI with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) pre and 6 months post treatments...
November 27, 2017: Hellenic Journal of Nuclear Medicine
Fani Melfou, Christos Lambrianidis, Philip C Grammaticos
An innovative biological energy has been observed related to the eye sight and fusing with another energy over tap water through a small metallic chain. The fused energy has been repeatedly described under standard conditions and it is characteristics vary according to the condition of the eye sight and the water content. This energy may be called: "EFI" (energy functioning, by fusion, independently).
September 2017: Hellenic Journal of Nuclear Medicine
Emmanouil Papanastasiou, Efstratios Moralidis, Anastasios Siountas
OBJECTIVE: In cardiac I-123 ((123)I) imaging downscatter from high energy emissions degrades the image and introduces distortion of semi-quantitative analysis when using a low energy collimator. The effect of a triple energy window (TEW) scatter correction technique, using windows immediately above and below the principal window centered on 159keV, was examined. MATERIALS AND METHODS: A hemispherical cardiac phantom was inserted into a cylindrical phantom and both were filled with radioactive (123)I water solutions...
May 2017: Hellenic Journal of Nuclear Medicine
Philip C Grammaticos, Dimitrios E Antoniou
The great progress of genetics research, during 2015-2017, will certainly influence all medical specialties including nuclear medicine. In nuclear medicine there are still problems to solve as to differentiate between infection, inflammation and cancer etc. Furthermore, in dosimetry and radiation protection there are worldwide problems. It has been reported that (64) Cu-cetuximab immune-PET represented EGFR expression levels in ESCC tumors and that (177) Lu-cetuximab radioimmunotherapy effectively inhibited the tumor growth...
May 2017: Hellenic Journal of Nuclear Medicine
Christophe Van de Wiele, Koenraad Verstraete, Sophie Bourgeois, Alex Maes
We report our fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FFDG PET/CT) findings in a 51 years old female presenting with B symptoms, respectively fever, night sweats and malaise, that underwent an (18)F-FDG PET/CT examination to exclude underlying lymphomatous disease. Whereas (18)F-FDG PET scan findings were negative, CT put to evidence the presence of multiple small lesions suggestive for multifocal hamartoma. On a subsequently performed magnetic resonance imaging (MRI) of the spleen, multiple infracentimetric foci were visualized displaying characteristic findings for hamartoma...
May 2017: Hellenic Journal of Nuclear Medicine
Raoul Muteganya, Ioannis Karfis, Carlos Artigas, Camilo Garcia, Feoli Francesco, Joseph Kerger, Patrick Flamen
We present herein a case of unusual (18)F-FDG PET-CT diffuse hypermetabolic liver uptake in melanoma patient treated by ipilimumab.
May 2017: Hellenic Journal of Nuclear Medicine
Valentina Lavelli, Cristina Ferrari, Artor Niccoli Asabella, Corinna Altini, Francesco Saverio Vella, Giuseppe Rubini
We report the case of a 69 years old man with left hip prosthesis, who presented clinical, biochemical and imaging signs of periprosthetic infection treated with linezolid, an antibacterial agent of the oxazolidinone class. Two weeks after this treatment, a fluorine-18-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan showed increased uptake in the skeleton and also increased uptake in several focal areas in the spine and near the prosthesis and the surgical wound on the left gluteus medius...
May 2017: Hellenic Journal of Nuclear Medicine
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