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Hellenic Journal of Nuclear Medicine

Kemin Huang, Yanlin Feng, Dejun Liu, Wen Li, Weitang Liang, Lin Li
OBJECTIVE: Conventional Single-photon emission tomography (SPET) myocardial perfusion imaging (MPI) is performed in the supine position range RAO 45o -LPO 45o , but the effect of other acquisition arcs on imaging quality have not been well described. In this study, we compared the radioactivity over left ventricle walls as measured by different acquisition arcs to identify the best specific applications. SUBJECTS AND METHODS: A total of 125 low-risk coronary heart disease patients underwent technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI) stress MPI, of which 52 received 360o acquisition with reconstruction using different 180o projections and the remaining 73 received conventional 180o (LPO 45o -RAO 45o ) and left-side 180o (POST 180o -ANT 0o ) acquisition consecutively...
May 2018: Hellenic Journal of Nuclear Medicine
Eleni Mavriopoulou, Petros Zampakis, Evaggelia Smpiliri, Trifon Spyridonidis, Efthymia Rapti, Uwe Haberkorn, Thomas Makatsoris, Dimitrios J Apostolopoulos
OBJECTIVE: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field ("near" whole-body) SPET/CT application in breast cancer (BC) patients. SUBJECTS AND METHODS: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Whole body scan and SPET/CT were interpreted separately...
May 2018: Hellenic Journal of Nuclear Medicine
Kequan Lou, Yushen Gu, Yan Hu, Siyang Wang, Hongcheng Shi
OBJECTIVE: In this study we aimed to evaluate the role of technetium-99m pertechnetate whole body scan (99m Tc WBS) with single photon emission tomography/computed tomography (SPET/CT) in detecting remnant thyroid tissue, nodal and distant metastases, in differentiated thyroid cancer (DTC) patients before radioiodine (131 I) therapy. SUBJECTS AND METHODS: A retrospective analysis was performed in 416 pathologically confirmed DTC patients with total/near-total thyroidectomy...
May 2018: Hellenic Journal of Nuclear Medicine
Philip C Grammaticos, Elpida Emmanouil-Nikoloussie, Christos Trontzos, Aekaterini Kaidoglou, Chrysi Foroglou
Dear Editor, This rather original investigation was performed some time ago but is still unpublished. Its aim was to estimate the effect of low or high temperature cow's milk given to breast feeding rats in order to study possible influence of this diet to rats, to their physical growth and also esophageal mucosal pathology. Ten white female Wistar rats, 20 days of age were separated from their mothers and divided in 2 groups of 5 members each. Five of them were fed with milk kept at 42o C by using a special warming device...
May 2018: Hellenic Journal of Nuclear Medicine
Özlem Şahin, Pembe Oltulu
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis with lipid-laden macrophages and fibrosis. Although ECD is a multisystemic disease, the most common finding is sclerotic bone involvement in the diametaphyseal regions of bilateral distal femur and in proximal and distal tibia. We present a 40 years old woman who for the last two years had various systemic symptoms, especially knee pain, polyuria and polydipsia. Although a "hot knee" pattern was seen in bone scintigraphy (BS), a femur biopsy was performed, due to the preliminary diagnosis of haematologic malignancy...
May 2018: Hellenic Journal of Nuclear Medicine
Inneke Willekens, Stefaan J Vandecasteele, Kristof Verhoeven, Frank De Geeter
The use of hyaluronic acid nanoshells has been proposed to encapsulate prodrugs and exploit the mechanisms of interactions between living cells, like endocytes or cancer cells and hyaluronic acid, which is a natural component of the extracellular matrix. In this review we describe the potential and the limits of this promising research trend and discuss the theoretical advantages of such an engineering approach. Is it a possible scalability to increase the efficacy and biodegradability of molecules like contrast media and radiotracers especially for neuroradiology and nuclear medicine studies...
May 2018: Hellenic Journal of Nuclear Medicine
Chao Miao, Lei Zhang, Ming Sun, Chao Ma
A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99m Tc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI)...
May 2018: Hellenic Journal of Nuclear Medicine
Dalveer Singh, Roslyn Horneman, Navjot Kaur Nagra
OBJECTIVE: Prostate specific membrane antigen (PSMA) positron emission tomography diagnostic computed tomography (PET/CT) is gaining an increasing role in the staging of prostate cancer and restaging in cases of biochemical recurrence. Our understanding of PSMA affinity for incidental pathological and non-pathological entities is also maturing although certain cases do present as diagnostic and management dilemmas. SUBJECT AND METHODS: We present a case of a 55 years old man with prostate adenocarcinoma, with incidentally found pancreatic and thyroid lesions showing PSMA avidity...
May 2018: Hellenic Journal of Nuclear Medicine
Slobodanka Lj Beatović, Marija Radulović, Milica M Janković, Vera M Artiko, Boris Ajdinović, Dragana P Šobić-Šaranović
OBJECTIVE: The aim of this study was to assess the diagnostic ability of renal output efficiency (OE), normalized residual activity (NORA) and conventional interpretation of the diethylene triamine pentaacetic acid (99m Tc-DTPA) diuretic renogram (CIR) in diagnosing urine flow obstruction. SUBJECTS AND METHODS: Group A consisted of 73 obstructed kidneys and Group B of 80 kidneys with dilated upper urinary tract. Forty eight kidneys were examined as the control Group C...
May 2018: Hellenic Journal of Nuclear Medicine
Jianwei Yuan, Xinchao You, Guoying Ni, Tianfang Wang, Shelley Cavezza, Xuan Pan, Xiaosong Liu
OBJECTIVE: We recently showed that host defense caerin peptides isolated from Australian frog tree were able to inhibit cervical cancer tumour cell growth in vitro. We wished to determine if radioactive isotope iodine-125 (125 I) can be labeled to caerin 1.9 peptide and if this peptide is bioactive for breast cancer cells treatment. SUBJECTS AND METHODS: The biological function of caerin (1.1 and 1.9) peptides were investigated by in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay...
May 2018: Hellenic Journal of Nuclear Medicine
Seol H Park, Minjung Seo, Hye-Jeong Choi, Kyungkyg Bae, Minseo Bang, Sungmin Jun
OBJECTIVE: To evaluate the reliability of a method using the peri-tumoral halo layer (PHL) for assessing tumor size in breast cancer patients on the fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) scan compared to MRI and pathology. SUBJECTS AND METHODS: Among 121 patients with breast cancer who underwent both 18 F-FDG PET/CT and MRI between March 2013 and June 2016, 59 patients were included in this study. Exclusion criteria were as follows: history of neoadjuvant therapy, history of pre-operative mammotome, insufficient pathologic/radiologic size report, clustered tumor, positive tumor resection margin, 18 F-FDG non-avid tumor...
May 2018: Hellenic Journal of Nuclear Medicine
Abdullah Al-Zaghal, Dani P Yellanki, Cyrus Ayubcha, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: This study was conducted to determine the role of computed tomography (CT)-based segmentation methodology to semi-quantify the degree of inflammation and reactive bone formation in the knee joints by fluorine-18-fluorodeoxyglucose (18 F-FDG) and 18 F-sodium fluoride positron emission tomography/CT (18 F-NaF PET/CT) imaging, respectively. Furthermore, we assessed the impact of aging and body mass index (BMI) on these biological responses. SUBJECTS AND METHODS: In this retrospective study, we examined a total of 97 subjects who had undergone both 18 F-FDG and 18 F-NaF PET/CT scanning...
May 2018: Hellenic Journal of Nuclear Medicine
Jonah Peter, Mohsen Khosravi, Thomas J Werner, Abass Alavi
OBJECTIVE: The purpose of this study was to evaluate the utility of global semi-quantitative analysis via fluorine-18-flurodeoxyglucose positron emission tomography (18 F-FDG PET) at lateralizing seizure foci and diagnosing patients with unilateral temporal lobe epilepsy (TLE). METHODS: Seventeen patients with unilateral TLE (11 right TLE and 6 left TLE) were retrospectively selected for semi-quantitative 18 F-FDG PET analysis. Twenty-three control subjects with a Mini Mental State Examination (MMSE) score of 29 or greater were selected for comparison...
May 2018: Hellenic Journal of Nuclear Medicine
Zhongke Huang, Cen Lou
BACKGROUND: We aimed to semi-quantitatively evaluate using technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) scintigraphy the efficacy of neoadjuvant chemotherapy in osteosarcoma (OS) patients. SUBJECTS AND METHODS: A hundred and two patients with OS were retrospectively included in this study. All of them underwent 99m Tc-MIBI scintigraphy before and after neoadjuvant chemotherapy. Semi-quantitative parameters including the uptake ratio (UR) and alteration of uptake ratio (AUR) were calculated for each patient...
January 2018: Hellenic Journal of Nuclear Medicine
Vincenzo Frusciante, Cristina Ferrari, Manuela Totaro, Guido Valle, Claudio Carmine Guida, Filippo Aucella, Paola Caputo, Giuseppe Rubini
BACKGROUND: Congenital erythropoietic porphyria (CEP) is a rare autosomal recessively inherited disorder with chronic and relatively stable presentation. Till now brain blood flow derangements have been described only in acute hepatic porphyrias. We describe the first findings of brain perfusion defects, studied by single photon emission tomography/computed tomography (SPET/CT), in two patients affected by CEP, by using a semi-quantification anatomic-standardized voxel-based program compared with magnetic resonance imaging (MRI) results...
January 2018: Hellenic Journal of Nuclear Medicine
Poul F Høilund-Carlsen
Little was written in the stars above the city of Tabriz in Iran on March 15, 1938 indicating that a newborn citizen would immigrate to America and become a master of modern mo-lecular imaging with a sharp focus on 18 F-FDG PET to the benefit of millions of people around the world. Nonetheless, that's what happened. A gifted boy who lost his farther early and grew up with his uneducated mother and two siblings in humble circumstances to become a premium student, nationally no. 1 in mathematics while in school, and later a medical doctor before he decided in 1966 to seek his fortune in the US...
January 2018: Hellenic Journal of Nuclear Medicine
Elias Mazokopakis
Dear Editor, I read with great interest the article by Son et al about the radioprotective effect of selenium (Se) supplementation for the salivary glands from 131 I treatment in patients with differentiated thyroid cancer (DTC). In this study, 8 patients received 300μg of Se (as inorganic sodium selenite; selenase®) orally for 10 days, 3 days before to 6 days after 131 I treatment. On the occasion of the use of Se among these patients, I want with this letter to remind the differences among the prescribed Se supplements in clinical practice, such as the possible health consequences of Brazil nut consumption as another choice for the preparation of DTC patients for radioactive iodine (RAI) therapy...
January 2018: Hellenic Journal of Nuclear Medicine
Yiqiu Zhang, Beilei Li, Haojun Yu, Jun Hou, Hongcheng Shi
Ankylosing spondylitis (AS) is a form of arthritis that affects the spine, the sacroiliac joints and sometimes the hips and shoulders. Andersson lesion (AL), was first described by Andersson in 1937 as a destructive vertebral body and discovertebral portion of the spine in AS. In this case, we report a 50 years old man with medical history of AS diagnosed AL by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT).
January 2018: Hellenic Journal of Nuclear Medicine
Chao Ma, Jing Lu, Guoqiang Chen, Weixing Wang, Fu Su, Xinhui Su
Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm that has been described in various locations throughout the body, but is rarely observed in systemic lymph nodes. We present a case of a 63 years old woman with left inguinal lymphadenopathy accompanied by low-grade fever. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) revealed abnormal higher 18 F-FDG uptake on the neck, axillar, pulmonary hilar, mediastinal, mesenteric, retroperitoneal, pelvic and inguinal lymph nodes...
January 2018: Hellenic Journal of Nuclear Medicine
Chunmeng Chen, Chong Jiang, Lin Li
Retroperitoneal pleomorphic liposarcoma (RPLS) is the least common but the most aggressive subtype of liposarcoma. We herein report a case of tumor embolism (TE) to the inferior vena cava (IVC) and pulmonary arteries in a 54 years old woman with RPLS. The case suggests that fusion fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) can accurately detect occult TE. It also illustrates the usefulness of computed tomography (CT) and high 18 F-FDG uptake by PET/CT imaging for diagnosing such findings as filling defect in the veins and beaded pulmonary arteries as TE...
January 2018: Hellenic Journal of Nuclear Medicine
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