journal
MENU ▼
Read by QxMD icon Read
search

Neuroscience Bulletin

journal
https://www.readbyqxmd.com/read/28516282/region-specific-iron-measured-by-mri-as-a-biomarker-for-parkinson-s-disease
#1
REVIEW
Xiaojun Guan, Xiaojun Xu, Minming Zhang
The identification of sensitive and specific biomarkers for Parkinson's disease (PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD (motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei...
May 17, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28501905/investigation-of-pain-mechanisms-by-calcium-imaging-approaches
#2
REVIEW
Michael Anderson, Qin Zheng, Xinzhong Dong
Due to the complex circuitry and plethora of cell types involved in somatosensation, it is becoming increasingly important to be able to observe cellular activity at the population level. In addition, since cells rely on an intricate variety of extracellular factors, it is important to strive to maintain the physiological environment. Many electrophysiological techniques require the implementation of artificially-produced physiological environments and it can be difficult to assess the activity of many cells simultaneously...
May 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28501904/relationship-between-perisylvian-essential-language-sites-and-arcuate-fasciculus-in-the-left-hemisphere-of-healthy-adults
#3
Yu Lin, Kai Zhang, Shuai Li, Song Li, Jingna Jin, Fang Jin, Wen Qin, Long Hai, Meng Zhu, Chunshui Yu, Zhipeng Liu, Tao Yin, Xuejun Yang
Essential language sites and the arcuate fasciculus (AF) have been extensively researched. However, the relationship between them remains insufficiently studied, especially in healthy people. Navigated transcranial magnetic stimulation (nTMS) is increasingly used in language mapping. While enjoying the advantage of non-invasiveness, it is also capable of inducing a virtual lesion in the brain. Thus, it offers the possibility of using the virtual-lesion method to study the healthy brain. This study combined nTMS and diffusion tensor imaging (DTI) tractography to investigate the relationship between essential language sites and the AF in 30 healthy right-handed volunteers...
May 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28493169/empathy-for-distress-in-humans-and-rodents
#4
REVIEW
Jun Chen
Empathy is traditionally thought to be a unique ability of humans to feel, understand, and share the emotional state of others. However, the notion has been greatly challenged by the emerging discoveries of empathy for pain or distress in rodents. Because empathy is believed to be fundamental to the formation of prosocial, altruistic, and even moral behaviors in social animals and humans, studies associated with decoding the neural circuits and unraveling the underlying molecular and neural mechanisms of empathy for pain or distress in rodents would be very important and encouraging...
May 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28488083/ion-channel-genes-and-epilepsy-functional-alteration-pathogenic-potential-and-mechanism-of-epilepsy
#5
REVIEW
Feng Wei, Li-Min Yan, Tao Su, Na He, Zhi-Jian Lin, Jie Wang, Yi-Wu Shi, Yong-Hong Yi, Wei-Ping Liao
Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsy-associated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations (funotypes), and phenotypes of these mutations. Eleven genes featured loss-of-function mutations and six had gain-of-function mutations. Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A...
May 9, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28484964/spinal-circuits-transmitting-mechanical-pain-and-itch
#6
REVIEW
Bo Duan, Longzhen Cheng, Qiufu Ma
In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch. We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli, a hallmark symptom for many chronic pain or itch patients...
May 8, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28466257/cortical-representation-of-pain-and-touch-evidence-from-combined-functional-neuroimaging-and-electrophysiology-in-non-human-primates
#7
REVIEW
Li Min Chen
Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience (sensory-discriminative, affective/motivational, and cognitive) is represented by concurrent activity in widely-distributed brain regions (termed a network or pain matrix). Despite these breakthrough discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophysiological characterizations of these regions in the primate brain are lacking...
May 2, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28424991/expression-and-role-of-voltage-gated-sodium-channels-in-human-dorsal-root-ganglion-neurons-with-special-focus-on-nav1-7-species-differences-and-regulation-by-paclitaxel
#8
Wonseok Chang, Temugin Berta, Yong Ho Kim, Sanghoon Lee, Seok-Yong Lee, Ru-Rong Ji
Voltage-gated sodium channels (Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human dorsal root ganglion (hDRG) tissues from healthy donors. PCR analysis of seven DRG-expressed Nav subtypes revealed that the hDRG has higher expression of Nav1.7 (~50% of total Nav expression) and lower expression of Nav1.8 (~12%), whereas the mouse DRG has higher expression of Nav1.8 (~45%) and lower expression of Nav1...
April 19, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28424990/proteomic-analysis-of-the-hippocampus-in-mouse-models-of-trigeminal-neuralgia-and-inescapable-shock-induced-depression
#9
Qing-Huan Guo, Qing-He Tong, Ning Lu, Hong Cao, Liu Yang, Yu-Qiu Zhang
To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inescapable foot-shock-induced psychiatric disorders like depression in humans. Mass spectrometry was used to assess changes in the biomolecules and signaling pathways in the hippocampus from TN or LH mice...
April 19, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28401489/chemokine-receptor-cxcr3-in-the-spinal-cord-contributes-to-chronic-itch-in-mice
#10
Peng-Bo Jing, De-Li Cao, Si-Si Li, Meixuan Zhu, Xue-Qiang Bai, Xiao-Bo Wu, Yong-Jing Gao
Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis (ACD). CXCR3 in the spinal cord also contributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear. Here, we report that Cxcr3 (-/-) mice showed normal scratching in acute itch models but reduced scratching in chronic itch models of dry skin and ACD. In contrast, both formalin-induced acute pain and complete Freund's adjuvant-induced chronic inflammatory pain were reduced in Cxcr3 (-/-) mice...
April 11, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28389872/modulation-of-pain-and-itch-by-spinal-glia
#11
REVIEW
Makoto Tsuda
Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord...
April 7, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28389871/neurons-in-primary-motor-cortex-encode-hand-orientation-in-a-reach-to-grasp-task
#12
Chaolin Ma, Xuan Ma, Jing Fan, Jiping He
It is disputed whether those neurons in the primary motor cortex (M1) that encode hand orientation constitute an independent channel for orientation control in reach-to-grasp behaviors. Here, we trained two monkeys to reach forward and grasp objects positioned in the frontal plane at different orientation angles, and simultaneously recorded the activity of M1 neurons. Among the 2235 neurons recorded in M1, we found that 18.7% had a high correlation exclusively with hand orientation, 15.9% with movement direction, and 29...
April 7, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28389870/orexin-directly-enhances-the-excitability-of-globus-pallidus-internus-neurons-in-rat-by-co-activating-ox1-and-ox2-receptors
#13
He-Ren Gao, Qian-Xing Zhuang, Yong-Xiao Zhang, Zhang-Peng Chen, Bin Li, Xiao-Yang Zhang, Yi-Ting Zhong, Jian-Jun Wang, Jing-Ning Zhu
Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion, and cognition. However, the role of orexin in somatic motor control is still little known. Here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus (GPi), a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy...
April 7, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28365862/spinal-mechanisms-of-itch-transmission
#14
REVIEW
Devin M Barry, Admire Munanairi, Zhou-Feng Chen
Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide (GRP)-GRP receptor signaling...
April 1, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28365861/tnf-%C3%AE-tnfr1-signaling-is-required-for-the-full-expression-of-acute-and-chronic-itch-in-mice-via-peripheral-and-central-mechanisms
#15
Xiuhua Miao, Ya Huang, Teng-Teng Liu, Ran Guo, Bing Wang, Xue-Long Wang, Li-Hua Chen, Yan Zhou, Ru-Rong Ji, Tong Liu
Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha (TNF-α) and its receptors TNF receptor subtype-1 (TNFR1) and TNFR2 in acute and chronic itch in mice. Compared to wild-type (WT) mice, TNFR1-knockout (TNFR1-KO) and TNFR1/R2 double-KO (DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine (CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-α antagonist etanercept dose-dependently suppressed acute itch...
April 1, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28341977/genetic-analysis-of-fbxo2-fbxo6-fbxo12-and-fbxo41-variants-in-han-chinese-patients-with-sporadic-parkinson-s-disease
#16
Lamei Yuan, Zhi Song, Xiong Deng, Zhijian Yang, Yan Yang, Yi Guo, Hongwei Lu, Hao Deng
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene (FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs (FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants (rs9614, rs28924120, rs6442117, and rs61733550, respectively) were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in mainland China...
March 24, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28337696/cerebral-dopamine-neurotrophic-factor-a-potential-therapeutic-agent-for-parkinson-s-disease
#17
REVIEW
Tingting Tang, Yong Li, Qian Jiao, Xixun Du, Hong Jiang
The application of neurotrophic factors (NTFs) is a promising therapeutic strategy for neurodegenerative disorders such as Parkinson's disease (PD). Many NTFs have been reported to enhance the survival, regeneration, and differentiation of neurons and to induce synaptic plasticity. However, because of their potential side-effects and low efficacy after clinical administration, more potent treatments for neurodegenerative disorders are being sought. Cerebral dopamine neurotrophic factor (CDNF), a newly-identified NTF homologous to mesencephalic astrocyte-derived NTF, is structurally and functionally different from other NTFs, providing new hope especially for PD patients...
March 23, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28265898/spinal-ccl2-promotes-central-sensitization-long-term-potentiation-and-inflammatory-pain-via-ccr2-further-insights-into-molecular-synaptic-and-cellular-mechanisms
#18
Rou-Gang Xie, Yong-Jing Gao, Chul-Kyu Park, Ning Lu, Ceng Luo, Wen-Ting Wang, Sheng-Xi Wu, Ru-Rong Ji
Mounting evidence supports an important role of chemokines, produced by spinal cord astrocytes, in promoting central sensitization and chronic pain. In particular, CCL2 (C-C motif chemokine ligand 2) has been shown to enhance N-methyl-D-aspartate (NMDA)-induced currents in spinal outer lamina II (IIo) neurons. However, the exact molecular, synaptic, and cellular mechanisms by which CCL2 modulates central sensitization are still unclear. We found that spinal injection of the CCR2 antagonist RS504393 attenuated CCL2- and inflammation-induced hyperalgesia...
March 6, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28389869/homeostasis-of-synapses-expansion-during-wakefulness-contraction-during-sleep
#19
Chao He, Zhian Hu
No abstract text is available yet for this article.
June 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28337695/calcium-impermeable-nmda-receptor-a-novel-target-for-addiction
#20
Xiaodan Huang, Wei Ni, Changzheng Zhang
No abstract text is available yet for this article.
June 2017: Neuroscience Bulletin
journal
journal
41164
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"