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Neuroscience Bulletin

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https://www.readbyqxmd.com/read/30421271/independent-component-analysis-and-graph-theoretical-analysis-in-patients-with-narcolepsy
#1
Fulong Xiao, Chao Lu, Dianjiang Zhao, Qihong Zou, Liyue Xu, Jing Li, Jun Zhang, Fang Han
The present study was aimed to evaluate resting-state functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls. Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls. MRI data were first analyzed by group independent component analysis, then a graph theoretical method was applied to evaluate the topological properties in the whole brain. Small-world network parameters and nodal topological properties were measured...
November 13, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30417261/the-mitochondrion-a-potential-therapeutic-target-for-alzheimer-s-disease
#2
Mei-Hong Lu, Xiu-Yun Zhao, Pei-Pei Yao, De-En Xu, Quan-Hong Ma
No abstract text is available yet for this article.
November 12, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30413937/a-critical-time-window-for-the-selective-induction-of-hippocampal-memory-consolidation-by-a-brief-episode-of-slow-wave-sleep
#3
Yi Lu, Zheng-Gang Zhu, Qing-Qing Ma, Yun-Ting Su, Yong Han, Xiaodong Wang, Shumin Duan, Yan-Qin Yu
Although extensively studied, the exact role of sleep in learning and memory is still not very clear. Sleep deprivation has been most frequently used to explore the effects of sleep on learning and memory, but the results from such studies are inevitably complicated by concurrent stress and distress. Furthermore, it is not clear whether there is a strict time-window between sleep and memory consolidation. In the present study we were able to induce time-locked slow-wave sleep (SWS) in mice by optogenetically stimulating GABAergic neurons in the parafacial zone (PZ), providing a direct approach to analyze the influences of SWS on learning and memory with precise time-windows...
November 9, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30413936/a-shared-neural-node-for-multiple-innate-behaviors-in-drosophila
#4
Margaret S Ho
No abstract text is available yet for this article.
November 9, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30411305/standardized-operational-protocol-for-human-brain-banking-in-china
#5
Wenying Qiu, Hanlin Zhang, Aimin Bao, Keqing Zhu, Yue Huang, Xiaoxin Yan, Jing Zhang, Chunjiu Zhong, Yong Shen, Jiangning Zhou, Xiaoying Zheng, Liwei Zhang, Yousheng Shu, Beisha Tang, Zhenxin Zhang, Gang Wang, Ren Zhou, Bing Sun, Changlin Gong, Shumin Duan, Chao Ma
No abstract text is available yet for this article.
November 8, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30406345/comparison-of-reference-genes-for-transcriptional-studies-in-postmortem-human-brain-tissue-under-different-conditions
#6
LETTER
Qing Zhang, Hanlin Zhang, Fan Liu, Qian Yang, Kang Chen, Pan Liu, Tianyi Sun, Chao Ma, Wenying Qiu, Xiaojing Qian
No abstract text is available yet for this article.
November 7, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30390244/legal-and-ethical-issues-in-brain-banking
#7
Inge Huitinga, Mignon de Goeij, Natasja Klioueva
No abstract text is available yet for this article.
November 3, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30382507/phosphorylated-tdp-43-staging-of-primary-age-related-tauopathy
#8
Xiaoling Zhang, Bing Sun, Xing Wang, Hui Lu, Fangjie Shao, Annemieke J M Rozemuller, Huazheng Liang, Chong Liu, Jiadong Chen, Manli Huang, Keqing Zhu
Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study, we analyzed the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART, Alzheimer's disease (AD), and aging control cases. We examined the regional distribution patterns of pTDP-43 intraneuronal inclusions in PART with Braak NFT stages > 0 and ≤ IV, and a Thal phase of 0 (no beta-amyloid present)...
October 31, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30367336/pericyte-plasticity-in-the-brain
#9
REVIEW
Gabryella S P Santos, Luiz A V Magno, Marco A Romano-Silva, Akiva Mintz, Alexander Birbrair
Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using state-of-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain...
October 26, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30367335/association-of-genetic-polymorphisms-with-age-at-onset-in-han-chinese-patients-with-bipolar-disorder
#10
LETTER
Shao-Hua Hu, Yu-Qing Han, Ting-Ting Mou, Man-Li Huang, Jian-Bo Lai, Chee H Ng, Jing Lu, Qiao-Qiao Lu, Qiu-Yan Lin, Yu-Zhi Zhang, Jian-Bo Hu, Ning Wei, Wei-Juan Xu, Wei-Hua Zhou, Jing-Kai Chen, Chan-Chan Hu, Xiao-Yi Zhou, Shao-Jia Lu, Yi Xu
No abstract text is available yet for this article.
October 26, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30328008/blockade-of-endogenous-angiotensin-1-7-in-hypothalamic-paraventricular-nucleus-attenuates-high-salt-induced-sympathoexcitation-and-hypertension
#11
Xiao-Jing Yu, Yu-Wang Miao, Hong-Bao Li, Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang
Angiotensin (Ang)-(1-7) is an important biologically-active peptide of the renin-angiotensin system. This study was designed to determine whether inhibition of Ang-(1-7) in the hypothalamic paraventricular nucleus (PVN) attenuates sympathetic activity and elevates blood pressure by modulating pro-inflammatory cytokines (PICs) and oxidative stress in the PVN in salt-induced hypertension. Rats were fed either a high-salt (8% NaCl) or a normal salt diet (0.3% NaCl) for 10 weeks, followed by bilateral microinjections of the Ang-(1-7) antagonist A-779 or vehicle into the PVN...
October 16, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30318562/angiotensin-converting-enzyme-2-in-the-rostral-ventrolateral-medulla-regulates-cholinergic-signaling-and-cardiovascular-and-sympathetic-responses-in-hypertensive-rats
#12
Yu Deng, Xing Tan, Miao-Ling Li, Wei-Zhong Wang, Yang-Kai Wang
The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased...
October 15, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30315398/orthostatic-intolerance-and-coagulation-abnormalities-an-update
#13
Wei Quan, Yuchen Wang, Selena Chen, Junbao Du
No abstract text is available yet for this article.
October 13, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30311072/autonomic-disturbances-in-acute-cerebrovascular-disease
#14
REVIEW
Jun Mo, Lei Huang, Jianhua Peng, Umut Ocak, Jianmin Zhang, John H Zhang
Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system. We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia...
October 11, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30306532/the-possibility-and-molecular-mechanisms-of-cell-pyroptosis-after-cerebral-ischemia
#15
Zhaofei Dong, Kuang Pan, Jingrui Pan, Qingxia Peng, Yidong Wang
No abstract text is available yet for this article.
October 10, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30276527/intermedin-in-paraventricular-nucleus-attenuates-sympathoexcitation-and-decreases-tlr4-mediated-sympathetic-activation-via-adrenomedullin-receptors-in-rats-with-obesity-related-hypertension
#16
Jing Sun, Xing-Sheng Ren, Ying Kang, Hang-Bing Dai, Lei Ding, Ning Tong, Guo-Qing Zhu, Ye-Bo Zhou
Intermedin/adrenomedullin-2 (IMD/AM2), a member of the calcitonin gene-related peptide/AM family, plays an important role in protecting the cardiovascular system. However, its role in the enhanced sympathoexcitation in obesity-related hypertension is unknown. In this study, we investigated the effects of IMD in the paraventricular nucleus (PVN) of the hypothalamus on sympathetic nerve activity (SNA), and lipopolysaccharide (LPS)-induced sympathetic activation in obesity-related hypertensive (OH) rats induced by a high-fat diet for 12 weeks...
October 1, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30264378/folate-vitamin-b-alleviates-hyperhomocysteinemia-induced-alzheimer-like-pathologies-in-rat-retina
#17
Jing Guo, Shaozhou Ni, Qihang Li, Jian-Zhi Wang, Ying Yang
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD). Visual dysfunction is commonly found and is positively correlated with the severity of cognitive defects in AD patients. Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-β (Aβ) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus. Here, we investigated whether Hhcy also induces AD-like pathologies in the retina and the effects of FB...
September 28, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30255458/illuminating-the-activated-brain-emerging-activity-dependent-tools-to-capture-and-control-functional-neural-circuits
#18
REVIEW
Qiye He, Jihua Wang, Hailan Hu
Immediate-early genes (IEGs) have long been used to visualize neural activations induced by sensory and behavioral stimuli. Recent advances in imaging techniques have made it possible to use endogenous IEG signals to visualize and discriminate neural ensembles activated by multiple stimuli, and to map whole-brain-scale neural activation at single-neuron resolution. In addition, a collection of IEG-dependent molecular tools has been developed that can be used to complement the labeling of endogenous IEG genes and, especially, to manipulate activated neural ensembles in order to reveal the circuits and mechanisms underlying different behaviors...
September 26, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30225765/parkinson-s-disease-risk-variant-rs1109303-regulates-the-expression-of-inpp5k-and-crk-in-human-brain
#19
LETTER
Guiyou Liu, Yi Zhao, Jing-Yi Sun, Bao-Liang Sun
No abstract text is available yet for this article.
September 17, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30225764/cortical-inflammation-is-increased-in-a-dss-induced-colitis-mouse-model
#20
Ying Han, Tong Zhao, Xiang Cheng, Ming Zhao, Sheng-Hui Gong, Yong-Qi Zhao, Hai-Tao Wu, Ming Fan, Ling-Ling Zhu
While inflammatory bowel disease (IBD) might be a risk factor in the development of brain dysfunctions, the underlying mechanisms are largely unknown. Here, mice were treated with 5% dextran sodium sulfate (DSS) in drinking water and sacrificed on day 7. The serum level of IL-6 increased, accompanied by elevation of the IL-6 and TNF-α levels in cortical tissue. However, the endotoxin concentration in plasma and brain of mice with DSS-induced colitis showed a rising trend, but with no significant difference...
September 17, 2018: Neuroscience Bulletin
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