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Neuroscience Bulletin

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https://www.readbyqxmd.com/read/29243026/unraveling-the-mechanisms-of-memory-extinction
#1
Shao-Ling Han, Tian-Le Xu
No abstract text is available yet for this article.
December 14, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29204732/peripheral-leptin-signaling-mediates-formalin-induced-nociception
#2
Zhi-Jing Hu, Wei Han, Chang-Qing Cao, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang
Accumulating evidence suggests that obesity is associated with chronic pain. However, whether obesity is associated with acute inflammatory pain is unknown. Using a well-established obese mouse model induced by a high-fat diet, we found that: (1) the acute thermal pain sensory threshold did not change in obese mice; (2) the model obese mice had fewer nociceptive responses in formalin-induced inflammatory pain tests; restoring the obese mice to a chow diet for three weeks partly recovered their pain sensation; (3) leptin injection induced significant phosphorylation of STAT3 in control mice but not in obese mice, indicating the dysmodulation of topical leptin-leptin receptor signaling in these mice; and (4) leptin-leptin receptor signaling-deficient mice (ob/ob and db/db) or leptin-leptin receptor pathway blockade with a leptin receptor antagonist and the JAK2 inhibitor AG 490 in wild-type mice reduced their nociceptive responses in formalin tests...
December 5, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29196874/upregulation-of-spinal-voltage-dependent-anion-channel-1-contributes-to-bone-cancer-pain-hypersensitivity-in-rats
#3
Xiangpeng Kong, Jinrong Wei, Diyu Wang, Xiaoju Zhu, Youlang Zhou, Shusheng Wang, Guang-Yin Xu, Guo-Qin Jiang
Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4 (TLR4)...
December 1, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29185186/correction-to-gender-difference-in-acquired-seizure-susceptibility-in-adult-rats-after-early-complex-febrile-seizures
#4
Yun-Jian Dai, Zheng-Hao Xu, Bo Feng, Ceng-Lin Xu, Hua-Wei Zhao, Deng-Chang Wu, Wei-Wei Hu, Zhong Chen
In the original publication of the article, the representative EEG of female rat pups with FS in Figure 1 C and D was incorrectly intercepted from that of male rat pups. This correction does not affect the conclusions of the paper. Figure 1 has been corrected on the online PDF version and displayed below.
November 28, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29177768/familial-parkinson-s-disease-associated-l166p-mutant-dj-1-is-cleaved-by-mitochondrial-serine-protease-omi-htra2
#5
Kai Fu, Yanfei Wang, Dongkai Guo, Guanghui Wang, Haigang Ren
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in the DJ-1, including L166P, are responsible for recessive early-onset PD. Many lines of evidence have shown that L166P is not only a loss-of-function mutant, but also a pro-apoptotic-like protein that results in mitochondrial dysfunction. L166P has been reported to be unstable and to mislocalize to mitochondria. However, the mechanisms underlying the instability of L166P compared to wild-type DJ-1 remain largely unknown...
November 24, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29177767/membrane-aging-as-the-real-culprit-of-alzheimer-s-disease-modification-of-a-hypothesis
#6
REVIEW
Qiujian Yu, Chunjiu Zhong
Our previous studies proposed that Alzheimer's disease (AD) is a metabolic disorder and hypothesized that abnormal brain glucose metabolism inducing multiple pathophysiological cascades contributes to AD pathogenesis. Aging is one of the great significant risk factors for AD. Membrane aging is first prone to affect the function and structure of the brain by impairing glucose metabolism. We presume that risk factors of AD, including genetic factors (e.g., the apolipoprotein E ε4 allele and genetic mutations) and non-genetic factors (such as fat, diabetes, and cardiac failure) accelerate biomembrane aging and lead to the onset and development of the disease...
November 24, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29134450/comorbidity-burden-of-dementia-a-hospital-based-retrospective-study-from-2003-to-2012-in-seven-cities-in-china
#7
Qing-Hua Wang, Xin Wang, Xian-Le Bu, Yan Lian, Yang Xiang, Hong-Bo Luo, Hai-Qiang Zou, Jie Pu, Zhong-He Zhou, Xiao-Ping Cui, Qing-Song Wang, Xiang-Qun Shi, Wei Han, Qiang Wu, Hui-Sheng Chen, Hang Lin, Chang-Yue Gao, Li-Li Zhang, Zhi-Qiang Xu, Meng Zhang, Hua-Dong Zhou, Yan-Jiang Wang
Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease (AD), vascular dementia (VaD), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January 2003 to December 2012. The Charlson Comorbidity Index (CCI) was used to evaluate the comorbidity burden of the patients with dementia...
November 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29124672/radio-electric-asymmetric-conveyer-technology-modulates-neuroinflammation-in-a-mouse-model-of-neurodegeneration
#8
Maria Antonietta Panaro, Alessandra Aloisi, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco De Nuccio, Velia La Pesa, Antonia Cianciulli, Rosaria Rinaldi, Rosa Calvello, Vania Fontani, Salvatore Rinaldi
In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators...
November 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29124671/mutations-of-n-methyl-d-aspartate-receptor-subunits-in-epilepsy
#9
REVIEW
Xing-Xing Xu, Jian-Hong Luo
Epilepsy is one of the most common neurological diseases. Of all cases, 70%-80% are considered to be due to genetic factors. In recent years, a large number of genes have been identified as being involved in epilepsy. Among them, N-methyl-D-aspartate receptor (NMDAR) subunit-encoding genes represent a large proportion, suggesting an important role for NMDARs in epilepsy. In this review, we summarize and analyze the genotypes, functional alterations, and clinical aspects of NMDAR subunit mutations/variants identified from patients with epilepsy...
November 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29119345/impaired-face-perception-in-individuals-with-autism-spectrum-disorder-insights-on-diagnosis-and-treatment
#10
Taiyong Bi, Fang Fang
No abstract text is available yet for this article.
November 9, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29098645/neurocognitive-graphs-of-first-episode-schizophrenia-and-major-depression-based-on-cognitive-features
#11
Sugai Liang, Roberto Vega, Xiangzhen Kong, Wei Deng, Qiang Wang, Xiaohong Ma, Mingli Li, Xun Hu, Andrew J Greenshaw, Russell Greiner, Tao Li
Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs)...
November 2, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29094314/volumetric-changes-in-hippocampal-subregions-and-memory-performance-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#12
Caihong Ji, Lujia Zhu, Cong Chen, Shuang Wang, Leilei Zheng, Hong Li
In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients (21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors (CA1) exhibited maximum atrophy...
November 1, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29086908/melatonin-augments-the-effects-of-fluoxetine-on-depression-like-behavior-and-hippocampal-bdnf-trkb-signaling
#13
Kun Li, Si Shen, Yu-Tian Ji, Xu-Yun Li, Li-San Zhang, Xiao-Dong Wang
Depression is a debilitating psychiatric disorder with a huge socioeconomic burden, and its treatment relies on antidepressants including selective serotonin reuptake inhibitors (SSRIs). Recently, the melatonergic system that is closely associated with the serotonergic system has been implicated in the pathophysiology and treatment of depression. However, it remains unknown whether combined treatment with SSRI and melatonin has synergistic antidepressant effects. In this study, we applied a sub-chronic restraint stress paradigm, and evaluated the potential antidepressant effects of combined fluoxetine and melatonin in adult male mice...
October 31, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29064064/updated-review-on-the-clinical-use-of-repetitive-transcranial-magnetic-stimulation-in-psychiatric-disorders
#14
REVIEW
Qian Guo, Chunbo Li, Jijun Wang
With the ability to modulate cortical activity, repetitive transcranial magnetic stimulation (rTMS) is becoming increasingly important in clinical applications for psychiatric disorders. Previous studies have demonstrated its promising efficacy in depression and schizophrenia, and emerging evidence has also been found in patients with anxiety disorder, obsessive-compulsive disorder, and substance or food craving. However, the overall literature features some conflicting results, varied quality of studies, and a lack of consensus on optimal rTMS parameters...
October 24, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29022224/prepulse-inhibition-of-auditory-cortical-responses-in-the-caudolateral-superior-temporal-gyrus-in-macaca-mulatta
#15
Zuyue Chen, Lauri Parkkonen, Jingkuan Wei, Jin-Run Dong, Yuanye Ma, Synnöve Carlson
Prepulse inhibition (PPI) refers to a decreased response to a startling stimulus when another weaker stimulus precedes it. Most PPI studies have focused on the physiological startle reflex and fewer have reported the PPI of cortical responses. We recorded local field potentials (LFPs) in four monkeys and investigated whether the PPI of auditory cortical responses (alpha, beta, and gamma oscillations and evoked potentials) can be demonstrated in the caudolateral belt of the superior temporal gyrus (STGcb). We also investigated whether the presence of a conspecific, which draws attention away from the auditory stimuli, affects the PPI of auditory cortical responses...
October 11, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28936779/a-mouse-model-of-alzheimer-s-disease-with-transplanted-stem-cell-derived-human-neurons
#16
Yuankai Zhu, Hong Zhang
No abstract text is available yet for this article.
September 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28936771/functional-investigation-of-a-grin2a-variant-associated-with-rolandic-epilepsy
#17
Xing-Xing Xu, Xiao-Rong Liu, Cui-Ying Fan, Jin-Xing Lai, Yi-Wu Shi, Wei Yang, Tao Su, Jun-Yu Xu, Jian-Hong Luo, Wei-Ping Liao
N-methyl-D-aspartate receptors (NMDARs), a subtype of glutamate-gated ion channels, play a central role in epileptogenesis. Recent studies have identified an increasing number of GRIN2A (a gene encoding the NMDAR GluN2A subunit) mutations in patients with epilepsy. Phenotypes of GRIN2A mutations include epilepsy-aphasia disorders and other epileptic encephalopathies, which pose challenges in clinical treatment. Here we identified a heterozygous GRIN2A mutation (c.1341T>A, p.N447K) from a boy with Rolandic epilepsy by whole-exome sequencing...
September 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28936761/biomarkers-for-parkinson-s-disease-recent-advancement
#18
REVIEW
Sharvari Lotankar, Kedar S Prabhavalkar, Lokesh K Bhatt
As a multi-factorial degenerative disease, Parkinson's disease (PD) leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible. Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid, oxidative stress, neuroprotection, and inflammation...
October 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28936754/biomarker-discovery-in-parkinson-s-disease-present-challenges-and-future-opportunities
#19
EDITORIAL
Song Li, Weidong Le
No abstract text is available yet for this article.
October 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28924920/age-dependent-alpha-synuclein-accumulation-and-phosphorylation-in-the-enteric-nervous-system-in-a-transgenic-mouse-model-of-parkinson-s-disease
#20
Chong-Bin Zhong, Qian-Qian Chen, Caroline Haikal, Wen Li, Alexander Svanbergsson, Meike Diepenbroek, Jia-Yi Li
The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson's disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of α-synuclein (α-syn), the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model...
October 2017: Neuroscience Bulletin
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