Cheng Cheng, Guangjie Zhu, Kaijian Wang, Chuan Bu, Siyu Li, Yue Qiu, Jie Lu, Xinya Ji, Wenli Hao, Junguo Wang, Chengwen Zhu, Ye Yang, Yajun Gu, Xiaoyun Qian, Chenjie Yu, Xia Gao
Deafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown that Luzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance of Luzp2 in auditory function, we generated mice deficient in Luzp2. Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells...
April 9, 2024: Neuroscience Bulletin