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Future Oncology

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https://www.readbyqxmd.com/read/27908206/the-role-of-mesenchymal-stem-cells-in-oncology-and-regenerative-medicine
#1
Maliha Khan, Syeda Ezze Rukhshan Adil, Amanda L Olson
Mesenchymal stem cells (MSCs) have long been used as therapeutic agents in disease affecting various organ systems. However, MSCs are fast emerging as promising anticancer agents which have the potential to treat a number of different cancer types, including glioblastoma and metastatic breast, ovarian and hepatic carcinoma. The ability of MSC to migrate directly into the tumor microenvironment and to produce IFN-α and -β makes this possible. However, the possibility of MSC undergoing either malignant transformation or transformation into protumorigenic fibroblasts currently limits their role in clinical use...
December 2, 2016: Future Oncology
https://www.readbyqxmd.com/read/27897040/identification-of-novel-genes-by-whole-exome-sequencing-can-improve-gastric-cancer-precision-oncology
#2
Georgios D Lianos, Georgios K Glantzounis, Christina D Bali, Christos Katsios, Dimitrios H Roukos
AIM: By identifying cancer driver genes involved in tumorigenesis, whole-exome sequencing (WES) analyses enable the development of robust biomarkers and novel therapeutic targets to reach precision oncology. PATIENTS & METHODS: WES analyses were performed in matched gastric cancer-normal gastric tissues from two patients. We compared genes highlighted with those of a database and recent WES/whole-genome sequencing studies. RESULTS: We identified 32 highlighted gastric cancer genes, two of these (DEFB118 and RNF43) may provide future potential clinical implications...
November 29, 2016: Future Oncology
https://www.readbyqxmd.com/read/27884060/is-minimal-residual-disease-a-convincing-tool-to-determine-the-treatment-duration-of-immune-checkpoint-inhibitors
#3
Elie El Rassy, Tarek Assi, Joseph Kattan
No abstract text is available yet for this article.
November 25, 2016: Future Oncology
https://www.readbyqxmd.com/read/27882779/ipilimumab-from-preclinical-development-to-future-clinical-perspectives-in-melanoma
#4
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia
The arsenal for the treatment of metastatic melanoma is limited. A new approach to therapy using checkpoint blockade has improved overall survival in this patient population. Ipilimumab a CTLA-4 monoclonal antibody is a first in class drug that has pioneered this revolution. In this review, the authors provide an account of the different stages that led to the development of ipilimumab, its approval in the clinical setting for the treatment of advanced melanoma and ongoing investigations of combinatorial immune therapy...
November 24, 2016: Future Oncology
https://www.readbyqxmd.com/read/27882770/focal-therapy-as-primary-treatment-for-localized-prostate-cancer-definition-needs-and-future
#5
Adil Ouzzane, Nacim Betrouni, Massimo Valerio, Ardeshir Rastinehad, Pierre Colin, Guillaume Ploussard
Focal therapy (FT) may offer a promising treatment option in the field of low to intermediate risk localized prostate cancer. The aim of this concept is to combine minimal morbidity with cancer control as well as maintain the possibility of retreatment. Recent advances in MRI and targeted biopsy has improved the diagnostic pathway of prostate cancer and increased the interest in FT. However, before implementation of FT in routine clinical practice, several challenges are still to overcome including patient selection, treatment planning, post-therapy monitoring and definition of oncologic outcome surrogates...
November 24, 2016: Future Oncology
https://www.readbyqxmd.com/read/27875910/cancer-pain-a-review-of-epidemiology-clinical-quality-and-value-impact
#6
Nathan J Neufeld, Shereef M Elnahal, Ricardo H Alvarez
Cancer-related pain, reported by more than 70% of patients, is one of the most common and troublesome symptoms affecting patients with cancer. Despite the availability of effective treatments, cancer-related pain may be inadequately controlled in up to 50% of patients. With the growing focus on 'value' (healthcare outcomes achieved per dollar spent) in healthcare, the management of cancer-related pain has assumed novel significance in recent years. Data from initiatives that assess the quality of pain management in clinical practice have shown that effective management of cancer-related pain improves patient-perceived value of cancer treatment...
November 23, 2016: Future Oncology
https://www.readbyqxmd.com/read/27875904/timing-of-rectal-cancer-surgery-following-neoadjuvant-chemoradiation-how-close-are-we-to-striking-an-equipoise
#7
Savio George Barreto, Bhawna Sirohi, Shailesh V Shrikhande
No abstract text is available yet for this article.
November 23, 2016: Future Oncology
https://www.readbyqxmd.com/read/27875901/reducing-radiation-related-morbidity-in-the-treatment-of-nasopharyngeal-carcinoma
#8
Jason W Chan, Upendra Parvathaneni, Sue S Yom
While radiation therapy is the mainstay of treatment for nasopharyngeal carcinoma, the anatomic location of the nasopharynx in close proximity to radiation-sensitive organs such as the salivary glands, optic nerves and chiasm, cochlea, brainstem and temporal lobes presents a special challenge. Technological approaches to reducing the morbidity of nasopharyngeal cancer irradiation have been historically successful with the evolution from 2D techniques to increasingly conformal forms of radiation therapy. This report reviews normal tissue dose constraints and major considerations in target delineation for patients with nasopharyngeal cancer in the intensity-modulated radiation therapy era...
November 23, 2016: Future Oncology
https://www.readbyqxmd.com/read/27866423/risk-factors-for-bone-metastasis-in-completely-resected-non-small-cell-lung-cancer
#9
Hui Wang, Yan Zhang, Hui Zhu, Jinming Yu
AIM: We assessed risk factors for bone metastasis in patients with completely resected non-small-cell lung cancer (NSCLC). MATERIALS & METHODS: A total of 374 NSCLC patients who had undergone a complete resection from January 2008 to May 2012 were included in this retrospective study. The Kaplan-Meier method and multivariate Cox regression analysis were used to evaluate risk factors for bone metastasis. RESULTS: A total of 47 (47/374; 12.6%) patients developed bone metastasis up until the last follow-up time...
November 21, 2016: Future Oncology
https://www.readbyqxmd.com/read/27866412/failing-to-deliver-established-quality-treatment-for-cervical-cancer-what-is-going-on-and-how-can-we-improve-it
#10
Colin Hill, Daniel M Trifiletti, Timothy N Showalter
No abstract text is available yet for this article.
November 21, 2016: Future Oncology
https://www.readbyqxmd.com/read/27855516/risk-prediction-for-oral-potentially-malignant-disorders-using-fuzzy-analysis-of-cytomorphological-and-autofluorescence-alterations-in-habitual-smokers
#11
Ripon Sarkar, Susmita Dey, Mousumi Pal, Ranjan Rashmi Paul, Jyotirmoy Chatterjee, Chirasree RoyChaudhuri, Ananya Barui
AIM: This study aims to develop a novel noninvasive method for early cancer trend diagnosis in habitual smokers by corroborating cytomorphological and autofluorescence alterations. MATERIALS & METHODS: A total of 120 subjects were included and categorized into nonsmoker, smoker and clinically diagnosed oral potentially malignant disorder (OPMD) patients. Oral exfoliative epithelial cells were studied through differential interference contrast and fluorescence microscopy...
November 18, 2016: Future Oncology
https://www.readbyqxmd.com/read/27842456/survey-of-current-practices-from-the-international-stereotactic-body-radiotherapy-consortium-isbrtc-for-head-and-neck-cancers
#12
Irene Karam, Min Yao, Dwight E Heron, Ian Poon, Shlomo A Koyfman, Sue S Yom, Farzan Siddiqui, Eric Lartigau, Mustafa Cengiz, Hideya Yamazaki, Wendy Hara, Jack Phan, John A Vargo, Victor Lee, Robert L Foote, K William Harter, Nancy Y Lee, Arjun Sahgal, Simon S Lo
AIM: To provide a multi-institutional description of current practices of stereotactic body radiotherapy (SBRT) for head and neck cancer. MATERIALS & METHODS: 15 international institutions with significant experience in head and neck SBRT were asked to complete a questionnaire covering clinical and technical factors. RESULTS: SBRT is used 10-100% of the time for recurrent primary head and neck cancer, and 0-10% of the time in newly diagnosed disease...
November 15, 2016: Future Oncology
https://www.readbyqxmd.com/read/27842445/cabozantinib-in-genitourinary-malignancies
#13
Tian Zhang, Se Eun Park, Cierra Hong, Daniel J George
Cabozantinib inhibits a variety of cellular receptors including VEGFR1-3, MET, AXL, RET, FLT3 and KIT. These signaling pathways have been shown to be important in genitourinary malignancies. Along its clinical development, it has shown most activity in advanced renal cell carcinoma; the METEOR study compared cabozantinib to everolimus and showed clinically and statistically significant improvements in both progression-free survival and overall survival. Herein, we review the development of cabozantinib in the genitourinary malignancies of renal cell carcinoma, prostate adenocarcinoma and urothelial carcinoma...
November 15, 2016: Future Oncology
https://www.readbyqxmd.com/read/27841659/noncoding-rnas-as-novel-biomarkers-in-pancreatic-cancer-what-do-we-know
#14
Maria C Previdi, Pietro Carotenuto, Domenico Zito, Rosantony Pandolfo, Chiara Braconi
Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, mainly due to a lack of biomarkers to enable early diagnosis and a lack of prognostic markers that can inform decision-making, facilitating personalized treatment and an optimal clinical outcome. ncRNAs play an important role in pancreatic carcinogenesis. Here we review the literature on the role of ncRNAs as biomarkers in pancreatic cancer...
November 14, 2016: Future Oncology
https://www.readbyqxmd.com/read/27829286/gallbladder-cancer-results-achieved-and-future-challenges
#15
Isidoro Di Carlo, Adriana Toro
26th World Congress of International Association of Surgeons Gastroenterologists and Oncologists, Seoul, South Korea, 8-10 September 2016 This year, the 26th World Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists (IASGO) was hosted by Seoul in South Korea. The congress was extremely well organized, and the quality of the submissions and the relevance of the speakers were excellent. This report highlights the newest and most interesting results regarding the treatment of gallbladder tumors from the conference...
November 10, 2016: Future Oncology
https://www.readbyqxmd.com/read/27809605/from-bench-to-operating-theater-has-the-time-come-for-a-molecular-scalpel
#16
George Vartholomatos, George A Alexiou, Georgios D Lianos, Athanasios P Kyritsis
No abstract text is available yet for this article.
November 4, 2016: Future Oncology
https://www.readbyqxmd.com/read/27809604/video-assisted-thoracic-lobectomy-for-lung-cancer-in-italy-the-vats-group-project
#17
Roberto Crisci, Andrea Droghetti, Marcello Migliore, Alessandro Bertani, Alessandro Gonfiotti, Piergiorgio Solli
As part of the third Mediterranean Symposium in Thoracic Surgical Oncology, we introduce the Italian VATS Group ( http://vatsgroup.org/sito/index.php ). This national collaborative initiative was established in 2013 and started to recruit patients in January 2014; as of July 2016, 3680 patients have been enrolled in the database. Three different video-assisted thoracic surgery approaches have been predominantly used by Italian thoracic surgery centers, 71% of them preferentially adopting a multi-portal approach, with a 20% recorded morbidity...
November 4, 2016: Future Oncology
https://www.readbyqxmd.com/read/27809594/outcomes-and-toxicities-in-patients-treated-with-definitive-focal-therapy-for-primary-prostate-cancer-systematic-review
#18
Atallah Baydoun, Bryan Traughber, Nathan Morris, Michella Abi Zeid Daou, Michael McGraw, Tarun K Podder, Raymond F Muzic, Simon S Lo, Lee E Ponsky, Mitchell Machtay, Rodney Ellis
AIM: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCa). METHODS: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCa in adult male patients were included. RESULTS: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis...
November 4, 2016: Future Oncology
https://www.readbyqxmd.com/read/27806632/video-assisted-thoracic-surgery-lobectomy-in-patients-with-reduced-pulmonary-function-a-single-center-series
#19
Alessandro Bertani, Paolo Albino Ferrari, Lavinia De Monte, Emanuele Russo, Gioacchino Di Paola
Video-assisted thoracic surgery (VATS) is currently considered a 'gold standard' approach for pulmonary lobectomy in patients with early-stage lung cancer, displaying equal or superior results compared with an open traditional approach. In patients with limited pulmonary function, VATS lobectomy may reduce the impact of surgery and allow outcomes similar to patients with normal pulmonary function. The preliminary analysis of our initial, single center series of VATS lobectomy showed less complications and shorter postoperative length of stay compared with a historical series of open lobectomy patients...
November 3, 2016: Future Oncology
https://www.readbyqxmd.com/read/27806630/deregulated-mirnas-in-human-cervical-cancer-functional-importance-and-potential-clinical-use
#20
Jing Li, Qiuli Liu, Leslie H Clark, Haifeng Qiu, Victoria L Bae-Jump, Chunxiao Zhou
Cervical cancer (CC) is one of the most common malignancies affecting women worldwide. While the morbidity and mortality associated with CC are decreasing in western countries, they both remain high in developing countries. Unfortunately, many issues about molecular mechanisms of CC are not clear yet. miRNAs are a group of small noncoding RNAs that could post-transcriptionally modulate the expression of specific genes and participate in the initiation and progression of multiple diseases including CC. In the last decade, mounting evidences suggest an association between miRNAs and human papillomavirus infection, as well as variations in biologic behavior, treatment response and prognosis in CC...
November 3, 2016: Future Oncology
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