journal
MENU ▼
Read by QxMD icon Read
search

Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology

journal
https://www.readbyqxmd.com/read/30094695/correlates-of-long-term-opioid-abstinence-after-randomization-to-methadone-versus-buprenorphine-naloxone-in-a-multi-site-trial
#1
Yuhui Zhu, Elizabeth A Evans, Larissa J Mooney, Andrew J Saxon, Annamarie Kelleghan, Caroline Yoo, Yih-Ing Hser
Opioid use disorder (OUD) is a chronic, relapsing condition with severe negative health consequences. Previous studies have reported that 5-year opioid abstinence is a good predictor of reduced likelihoods of relapse, but factors that shape long-term opioid abstinence are poorly understood. The present study is based on data from a prospective study of 699 adults with OUD who had been randomized to either methadone or buprenorphine/naloxone and who were followed for at least 5 years. During the 5 years prior to the participants' last follow-up interview, 232 (33...
August 9, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/30069711/adenosine-promotes-the-recovery-of-mice-from-the-cuprizone-induced-behavioral-and-morphological-changes-while-effecting-on-microglia-and-inflammatory-cytokines-in-the-brain
#2
Jinling Zhang, Liu Yang, Zeman Fang, Jiming Kong, Qingjun Huang, Haiyun Xu
Recent studies have shown that multiple sclerosis (MS) and schizophrenia share similarities in some respects, including white matter damage and neuroinflammation. On the other hand, adenosine was reported to promote oligodendrocyte precursor maturation and remyelinating while influencing microglia activation. The aim of the present study was to examine possible beneficial effects of adenosine on the recovery of cuprizone (CPZ)-exposed mouse which has been used as an animal model of MS and schizophrenia as the CPZ-exposed mouse presents demyelination, oligodendrocyte loss, microglia accumulation, as well as behavioral changes...
August 1, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/30054897/pharmacological-effects-and-regulatory-mechanisms-of-tobacco-smoking-effects-on-food-intake-and-weight-control
#3
REVIEW
Tongyuan Hu, Zhongli Yang, Ming D Li
Beyond promoting smoking initiation and preventing smokers from quitting, nicotine can reduce food intake and body weight and thus is viewed as desirable by some smokers, especially many women. During the last several decades, the molecular mechanisms underlying the inverse correlation between smoking and body weight have been investigated extensively in both animals and humans. Nicotine's weight effects appear to result especially from the drug's stimulation of α3β4 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight...
July 27, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/30046962/psychosocial-correlates-of-monocyte-activation-and-hiv-persistence-in-methamphetamine-users
#4
Kaitlin Grosgebauer, Jessica Salinas, Mark Sharkey, Margaret Roach, Suresh Pallikkuth, Samantha E Dilworth, Savita Pahwa, Tulay Koru-Sengul, Mario Stevenson, Adam W Carrico
This cross-sectional study investigated the associations of psychosocial factors relevant to recovery from substance use disorders with monocyte activation and HIV persistence in a sample of 84 HIV-positive, methamphetamine-using sexual minority men with undetectable HIV viral load (<40 copies/mL). We examined if psychosocial factors were associated with decreased soluble CD14 (sCD14) and lower proviral HIV DNA. Multiple linear regression models adjusted for age, anti-retroviral therapy regimen, and CD4+ T-cell count...
July 25, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29995208/host-and-viral-factors-influencing-interplay-between-the-macrophage-and-hiv-1
#5
REVIEW
Viviane Machado Andrade, Mario Stevenson
HIV-1 persists in cellular reservoirs that cannot be eliminated by antiretroviral therapy (ART). The major reservoir in infected individuals on effective ART is composed of resting memory CD4+ T cells that harbor proviral cDNA, and undergo a state of latency in which viral gene expression is minimal to absent. The CD4+ T cell reservoir has been extensively characterized. However, other HIV-1-permissive cells may contribute to HIV-1 persistence. Lentiviruses have a long recognized association with macrophages...
July 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29987742/the-glucocorticoid-receptor-is-a-critical-regulator-of-hiv-latency-in-human-microglial-cells
#6
David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Curtis Dobrowolski, Jonathan Karn
We have developed models of HIV latency using microglia derived from adult human patient brain cortex and transformed with the SV40 T large and hTERT antigens. Latent clones infected by HIV reporter viruses display high levels of spontaneous HIV reactivation in culture. BrainPhys, a medium highly representative of the CNS extracellular environment, containing low glucose and 1% FBS, reduced, but did not prevent, HIV reactivation. We hypothesized that spontaneous HIV reactivation in culture was due to the expression of pro-inflammatory genes, such as TNF-α, taking place in the absence of the natural inhibitory signals from astrocytes and neurons...
July 10, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29987592/dimethyl-fumarate-prevents-hiv-induced-lysosomal-dysfunction-and-cathepsin-b-release-from-macrophages
#7
Lester J Rosario-Rodríguez, Krystal Colón, Gabriel Borges-Vélez, Karla Negrón, Loyda M Meléndez
HIV-associated neurocognitive disorders (HAND) are prevalent despite combined antiretroviral therapy, affecting nearly half of HIV-infected patients worldwide. During HIV infection of macrophages secretion of the lysosomal protein, cathepsin B, is increased. Secreted cathepsin B has been shown to induce neurotoxicity. Oxidative stress is increased in HIV-infected patients, while antioxidants are decreased in monocytes from patients with HIV-associated dementia (HAD). Dimethyl fumarate (DMF), an antioxidant, has been reported to decrease HIV replication and neurotoxicity mediated by HIV-infected macrophages...
July 9, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29987591/ethanol-s-effects-on-transient-receptor-potential-channel-expression-in-brain-microvascular-endothelial-cells
#8
Sulie L Chang, Wenfei Huang, Xin Mao, Michelle L Mack
Ethanol (EtOH), the main ingredient in alcoholic beverages, is well known for its behavioral, physiological, and immunosuppressive effects. There is evidence that EtOH acts through protein targets to exert its physiological effects; however, the mechanisms underlying EtOH's effects on inflammatory processes, particularly at the blood-brain barrier (BBB), are still poorly understood. Transient receptor potential (TRP) channels, the vanguards of human sensory systems, are novel molecular receptors significantly affected by EtOH, and are heavily expressed in brain microvascular endothelial cells (BMVECs), one of the cellular constituents of the BBB...
July 9, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29981000/ccr2-on-peripheral-blood-cd14-cd16-monocytes-correlates-with-neuronal-damage-hiv-associated-neurocognitive-disorders-and-peripheral-hiv-dna-reseeding-of-cns-reservoirs
#9
Mike Veenstra, Desiree A Byrd, Matilde Inglese, Korhan Buyukturkoglu, Dionna W Williams, Lazar Fleysher, Ming Li, Lucio Gama, Rosiris León-Rivera, Tina M Calderon, Janice E Clements, Susan Morgello, Joan W Berman
HIV-associated neurocognitive disorders (HAND) occur in ~50% of HIV infected individuals despite combined antiretroviral therapy. Transmigration into the CNS of CD14+ CD16+ monocytes, particularly those that are HIV infected and express increased surface chemokine receptor CCR2, contributes to neuroinflammation and HAND. To examine whether in HIV infected individuals CCR2 on CD14+ CD16+ monocytes serves as a potential peripheral blood biomarker of HAND, we examined a cohort of 45 HIV infected people. We correlated CCR2 on CD14+ CD16+ monocytes with cognitive status, proton magnetic resonance spectroscopy (1 H-MRS) measured neurometabolite levels, and peripheral blood mononuclear cell (PBMC) HIV DNA copies...
July 6, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29909495/the-neuro-immune-regulators-niregs-promote-tissue-resilience-a-vital-component-of-the-host-s-defense-strategy-against-neuroinflammation
#10
REVIEW
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29790106/imaging-reporter-strategy-to-monitor-gene-activation-of-microglia-polarisation-states-under-stimulation
#11
Franziska M Collmann, Rory Pijnenburg, Gabriele Schneider, Cordula Schäfer, Kat Folz-Donahue, Christian Kukat, Mathias Hoehn
Microglial cells as innate immune key players have a critical and unique role in neurodegenerative disorders. They strongly interact with their microenvironment in a complex manner and react to changes by switching their phenotype and functional activation states. In order to understand the development of brain diseases, it is imperative to elucidate up- or down-regulation of genes involved in microglia polarisation in time-profile by a simple-to-use strategy. Here, we present a new imaging strategy to follow promoter activity of genes involved in microglia polarisation...
May 22, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29790105/physostigmine-restores-impaired-autophagy-in-the-rat-hippocampus-after-surgery-stress-and-lps-treatment
#12
Clarissa von Haefen, Marco Sifringer, Stefanie Endesfelder, Alexander Kalb, Adrián González-López, Annalena Tegethoff, Nadine Paeschke, Claudia D Spies
Tissue damage and pathogen invasion during surgical trauma have been identified as contributing factors leading to neuroinflammation in the hippocampus, which can be protected by stimulation of the cholinergic anti-inflammatory pathway using the acetylcholinesterase inhibitor physostigmine. Macroautophagy, an intracellular degradation pathway used to recycle and eliminate damaged proteins and organelles by lysosomal digestion, seems to be important for cell survival under stress conditions. This study aimed to examine the role of autophagy in physostigmine-mediated hippocampal cell protection in a rat model of surgery stress...
May 22, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29550892/a-role-for-the-non-receptor-tyrosine-kinase-abl2-arg-in-experimental-neuroinflammation
#13
Freja Aksel Jacobsen, Alexander N Scherer, Jeppe Mouritsen, Hera Bragadóttir, B Thomas Bäckström, Samra Sardar, Dan Holmberg, Anthony J Koleske, Åsa Andersson
Multiple sclerosis is a neuroinflammatory degenerative disease, caused by activated immune cells infiltrating the CNS. The disease etiology involves both genetic and environmental factors. The mouse genetic locus, Eae27, linked to disease development in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis, was studied in order to identify contributing disease susceptibility factors and potential drug targets for multiple sclerosis. Studies of an Eae27 congenic mouse strain, revealed that genetic variation within Eae27 influences EAE development...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29516269/tau-phosphorylation-is-impacted-by-rare-akap9-mutations-associated-with-alzheimer-disease-in-african-americans
#14
Tsuneya Ikezu, Cidi Chen, Annina M DeLeo, Ella Zeldich, M Daniele Fallin, Nicholas M Kanaan, Kathryn L Lunetta, Carmela R Abraham, Mark W Logue, Lindsay A Farrer
We studied the effect of two rare mutations (rs144662445 and rs149979685) in the A-kinase anchoring protein 9 (AKAP9) gene, previously associated with Alzheimer disease (AD) in African Americans (AA), on post-translational modifications of AD-related pathogenic molecules, amyloid precursor protein (APP) and microtubule-associated protein Tau using lymphoblastoid cell lines (LCLs) from 11 AA subjects with at least one AKAP9 mutation and 17 AA subjects lacking these mutations. LCLs were transduced by viral vectors expressing causative AD mutations in APP or human full-length wild type Tau...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29492824/inflammasome-activation-by-methamphetamine-potentiates-lipopolysaccharide-stimulation-of-il-1%C3%AE-production-in-microglia
#15
Enquan Xu, Jianuo Liu, Han Liu, Xiaobei Wang, Huangui Xiong
Methamphetamine (Meth) is an addictive psychostimulant abused worldwide. Ample evidence indicate that chronic abuse of Meth induces neurotoxicity via microglia-associated neuroinflammation and the activated microglia present in both Meth-administered animals and human abusers. The development of anti-neuroinflammation as a therapeutic strategy against Meth dependence promotes research to identify inflammatory pathways that are specifically tied to Meth-induced neurotoxicity. Currently, the exact mechanisms for Meth-induced microglia activation are largely unknown...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29464588/functional-meningeal-lymphatics-and-cerebrospinal-fluid-outflow
#16
Rajnish S Dave, Pooja Jain, Siddappa N Byrareddy
Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervical lymph nodes. In this letter, we highlighted the role of functional meningeal lymphatics and cerebrospinal fluid outflow.
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29429030/nucleoside-reverse-transcriptase-inhibitors-nrtis-induce-pathological-pain-through-wnt5a-mediated-neuroinflammation-in-aging-mice
#17
Subo Yuan, Yuqiang Shi, Kaiwen Guo, Shao-Jun Tang
Highly Active Antiretroviral Therapy (HAART) has significantly contributed to the increase of HIV-infected survivors over 50 years of age. Unfortunately, patients are required to stay on long-term HAART, which may be causally related to the development of neurological problems such as chronic pain. Little is known about the contribution of HAART or its therapeutic agents to the pathogenesis of pain during aging. In this study, we determined the effect of nucleoside reverse transcriptase inhibitors (NRTIs) on the development of mechanical allodynia and the potential underlying mechanism in aging mice (15...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29340893/a-prospective-study-of-humoral-and-cellular-immune-responses-to-hepatitis-b-vaccination-in-habitual-marijuana-smokers
#18
Sylvia M Kiertscher, Pallavi R Gangalum, Grace Ibrahim, Donald P Tashkin, Michael D Roth
Exposure to Δ9 -tetrahydrocannabinol (THC) in vitro and in animal models can significantly impair the differentiation, activation and function of dendritic cells, T cells and B cells. However, studies directly assessing the impact of marijuana smoking on human immunity are lacking. A prospective study of immune responses to a standard hepatitis B vaccination was therefore carried out in a matched cohort of 9 marijuana smokers (MS) and 9 nonsmokers (NS). In addition to their regular marijuana use, MS smoked four marijuana cigarettes in a monitored setting on the day of each vaccination...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29288344/fdc-tfh-interactions-within-cervical-lymph-nodes-of-siv-infected-rhesus-macaques
#19
Rajnish S Dave, Ravi K Sharma, Roshell R Muir, Elias Haddad, Sanjeev Gumber, Francois Villinger, Artinder P Nehra, Zafar K Khan, Brian Wigdahl, Aftab A Ansari, Siddappa N Byrareddy, Pooja Jain
Cerebrospinal fluid (CSF) drains via the lymphatic drainage pathway. This lymphatic pathway connects the central nervous system (CNS) to the cervical lymph node (CLN). As the CSF drains to CLN via the dural and nasal lymphatics, T cells and antigen presenting cells pass along the channels from the subarachnoid space through the cribriform plate. Human immunodeficiency virus (HIV) may also egress from the CNS along this pathway. As a result, HIV egressing from the CNS may accumulate within the CLN. Towards this objective, we analyzed CLNs isolated from rhesus macaques that were chronically-infected with simian immunodeficiency virus (SIV)...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29280055/sirtuin-1-chromatin-binding-dynamics-points-to-a-common-mechanism-regulating-inflammatory-targets-in-siv-infection-and-in-the-aging-brain
#20
Nikki Bortell, Liana Basova, Julia A Najera, Brenda Morsey, Howard S Fox, Maria Cecilia Garibaldi Marcondes
Microglia and macrophages are the main non-neuronal subsets of myeloid origin in the brain, and are critical regulators in neurodegenerative disorders, where inflammation is a key factor. Since HIV infection results in neurological perturbations that are similar to those in aging, we examined microglial and infiltrating myeloid subsets in the search for changes that might resemble the ones in aging. For that, we used the SIV infection in rhesus macaques to model neuroAIDS. We found that Sirt-1, a molecule that impacts survival and health in many models, was decreased in cell preparations containing a majority of microglia and myeloid cells from the brain of infected macaques...
June 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
journal
journal
41158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"