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Congenital Heart Disease

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https://www.readbyqxmd.com/read/29436781/rsv-prophylaxis-guideline-changes-and-outcomes-in-children-with-congenital-heart-disease
#1
Adam S Walpert, Ian D Thomas, Merlin C Lowe, Michael D Seckeler
OBJECTIVE: The aim of this study was to compare inpatient outcomes and costs for children with respiratory syncytial virus and congenital heart disease before and after the change in management guidelines for respiratory syncytial virus prophylaxis. DESIGN: Hospital discharge data from the Vizient (formerly University HealthSystem Consortium) were queried from October 2012 to June 2014 (Era 1) and July 2014 to April 2016 (Era 2) for patients aged <24 months with an any International Classification of Disease (ICD)-9 or ICD-10 code for congenital heart disease (745-747...
February 13, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29431296/utility-of-incomplete-right-bundle-branch-block-as-an-isolated-ecg-finding-in-children-undergoing-initial-cardiac-evaluation
#2
Omar Meziab, Dominic J Abrams, Mark E Alexander, Laura Bevilacqua, Vassilios Bezzerides, Doug Y Mah, Edward P Walsh, John K Triedman
OBJECTIVE: This study evaluates the ability of experienced pediatric electrophysiologists (EPs) to reliably classify incomplete right bundle branch block (IRBBB) and assesses its clinical utility as an isolated ECG finding in a group of healthy outpatient children without prior cardiac evaluation. DESIGN: We performed a retrospective analysis of all electrocardiographic and echocardiographic records at Boston Children's Hospital between January 1, 2005, and December 31, 2014...
February 12, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29431283/predictive-value-of-presuperior-cavopulmonary-anastomosis-cardiac-catheterization-at-increased-altitude
#3
Michael V Di Maria, Matthew Mulvahill, James Jaggers, David Dunbar Ivy, Adel K Younoszai
OBJECTIVE: Infants with single ventricle physiology typically undergo cardiac catheterization prior to superior cavopulmonary anastomosis (SCPA) to assess operative suitability. Predictors of poor outcome at sea level include elevated pulmonary artery pressure (mPAP), indexed pulmonary vascular resistance (PVRi), age <3 months, significant atrioventricular valve regurgitation, among others. Increased altitude has vasoconstrictive effects on the pulmonary vasculature, which may affect pre-SCPA hemodynamics and outcomes...
February 12, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29423938/effects-of-inspiratory-muscle-training-in-chronic-heart-failure-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Jing Wu, Li Kuang, Lijuan Fu
OBJECTIVE: The aim of this study was to evaluate the effects of inspiratory muscle training (IMT) in chronic heart failure (CHF) patients. DESIGN: We searched MEDLINE, EMBASE, Cochrane Library, CINHAL, and CBMdisc to collect controlled trials on the application of inspiratory muscle training in CHF patients from the establishment of these databases to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the quality of literature...
February 8, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29400005/optimizing-patient-care-and-outcomes-through-the-congenital-heart-center-of-the-21st-century
#5
Jeffery B Anderson, Devyani Chowdhury, Jean A Connor, Curt J Daniels, Craig E Fleishman, Michael Gaies, Jeffrey Jacobs, John Kugler, Nicolas Madsen, Robert H Beekman, Stacey Lihn, Kay Stewart-Huey, Robert Vincent, Robert Campbell
Pediatric cardiovascular services are responding to the dynamic changes in the medical environment, including the business of medicine. The opportunity to advance our pediatric cardiology field through collaboration is now realized, permitting us to define meaningful quality metrics and establish national benchmarks through multicenter efforts. In March 2016, the American College of Cardiology hosted the first Adult Congenital/Pediatric Cardiology Section Congenital Heart Community Day. This was an open participation meeting for clinicians, administrators, patients/parents to propose metrics that optimize patient care and outcomes for a state-of-the-art congenital heart center of the 21st century...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29399997/clinical-outcomes-of-percutaneous-or-surgical-closure-of-ruptured-sinus-of-valsalva-aneurysm
#6
Jia-Wang Xiao, Qi-Guang Wang, Duan-Zhen Zhang, Chun-Sheng Cui, Xiumin Han, Po Zhang, Chuangju Hou, Xian-Yang Zhu
OBJECTIVE: To evaluate the clinical efficacy, safety, and long-term outcomes of percutaneous closure (PC) and surgical repair of ruptured sinus of Valsalva aneurysm (RSVA). METHODS: Eighty-five consecutive patients with RSVA were included in this study. Patients were considered candidates for PC if they met the criterion, surgical repair was performed on patients who were unsuitable or failed PC. Of them, 30 patients underwent PC, while the other 55 patients had surgical repair...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29399970/analysis-of-dicer1-in-familial-and-sporadic-cases-of-transposition-of-the-great-arteries
#7
Nelly Sabbaghian, Maria C Digilio, Gillian M Blue, Timothée Revil, David S Winlaw, William D Foulkes
OBJECTIVE: We previously identified a pathogenic germline DICER1 variant in a child with transposition of the great arteries who was a member of a family with DICER1 syndrome. In view of a report linking Dicer1 knockout in murine cardiomyocytes to cardiac outflow defects, we investigated the involvement of DICER1 in transposition of the great arteries. DESIGN: We used Fluidigm access array followed by next generation sequencing to screen for variants in the coding exons, their exon/intron boundaries and the 3' untranslated region of DICER1 in patient DNA...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29399969/role-of-virtual-reality-in-congenital-heart-disease
#8
Chin Siang Ong, Aravind Krishnan, Chen Yu Huang, Philip Spevak, Luca Vricella, Narutoshi Hibino, Juan R Garcia, Lasya Gaur
OBJECTIVE: New platforms for patient imaging present opportunities for improved surgical planning in complex congenital heart disease (CHD). Virtual reality (VR) allows for interactive manipulation of high-resolution representations of patient-specific imaging data, as a supplement to traditional 2D visualizations and 3D printed heart models. DESIGN: We present the novel use of VR for the presurgical planning of cardiac surgery in two infants with complex CHD to demonstrate interactive real-time views of complex intra and extracardiac anatomy...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29377543/novel-mutation-of-gata4-gene-in-kurdish-population-of-iran-with-nonsyndromic-congenital-heart-septals-defects
#9
Fariborz Soheili, Zahra Jalili, Mahtab Rahbar, Zahed Khatooni, Amir Mashayekhi, Hossein Jafari
BACKGROUND: The mutations in GATA4 gene induce inherited atrial and ventricular septation defects, which is the most frequent forms of congenital heart defects (CHDs) constituting about half of all cases. METHOD: We have performed High resolution melting (HRM) mutation scanning of GATA4 coding exons of nonsyndrome 100 patients as a case group including 39 atrial septal defects (ASD), 57 ventricular septal defects (VSD) and four patients with both above defects and 50 healthy individuals as a control group...
January 28, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29377498/intrauterine-growth-restriction-is-not-associated-with-decreased-exercise-capacity-in-adolescents-with-congenital-heart-disease
#10
Andrew D Spearman, Rohit S Loomba, Michael Danduran, Joshua Kovach
OBJECTIVE: Multiple studies demonstrate the association of intrauterine growth restriction (IUGR) with impaired aerobic fitness in adolescents and adults. To our knowledge, there are no studies including individuals with the history of both IUGR and congenital heart disease (CHD). Thus, we sought to evaluate the impact of IUGR on exercise capacity in adolescents with CHD. STUDY DESIGN: We conducted a retrospective chart review of patients <18 years of age who underwent cardiopulmonary exercise testing (CPET) between August 1, 2003 and July 1, 2016...
January 28, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29372620/decreased-inappropriate-shocks-with-new-generation-icds-in-children-and-patients-with-congenital-heart-disease
#11
Stephanie A Goldstein, Martin J LaPage, Brynn E Dechert, Gerald A Serwer, Sunkyung Yu, Ray E Lowery, David J Bradley
OBJECTIVE: Inappropriate implantable cardioverter defibrillator (ICD) shocks in children and patients with congenital heart disease (CHD) remain a major complication of device therapy, occurring in as many as 50% of children with ICDs. New generation devices include algorithms designed to minimize inappropriate shocks. This study aimed to evaluate the effect of new generation ICDs on the incidence of inappropriate shocks in the pediatric and CHD population. DESIGN: Retrospective study of patients with CHD or under age 25 receiving ICDs between 2000 and 2015...
January 25, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29372615/pattern-of-inpatient-pediatric-cardiology-consultations-in-sub-saharan-africa
#12
Kriti Puri, Peter Kazembe, Treasure Mkaliainga, Msandeni Chiume, Antonio G Cabrera, Amy Sims Sanyahumbi
Malawi is one of the poorest nations in the world, ranked 151st among 195 countries by the World Bank, with an under-5-year mortality rate of 63 per 1000 live births. There are no previous studies describing the spectrum of inpatient pediatric cardiology consultations in sub-Saharan Africa. A descriptive cohort study was performed at Kamuzu Central Hospital (KCH), a tertiary care hospital in Lilongwe, Malawi. Demographic, anthropometric, and clinical information for all cardiology consults patients aged 0-18 years admitted to the children's wards over a period of 1 month was reviewed...
January 25, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29372591/clinical-yield-of-fetal-echocardiography-for-suboptimal-cardiac-visualization-on-obstetric-ultrasound
#13
Rick D Vavolizza, Pe'er Dar, Barrie Suskin, Robert M Moore, Kenan W D Stern
OBJECTIVE: Suboptimal cardiac imaging on obstetric ultrasound is a frequent referral indication for fetal echocardiography, even in the absence of typical risk factors for fetal cardiac disease. The clinical profile of patients and findings of examinations performed for such an indication are not well defined. Given the increased cost, time and resource utilization of fetal echocardiography, we sought to determine the clinical findings of such referrals. STUDY DESIGN: We performed a single-center review of such referrals from January 2010 to June 2016...
January 25, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29372588/five-decades-of-the-fontan-operation-a-systematic-review-of-international-reports-on-outcomes-after-univentricular-palliation
#14
REVIEW
Laura S Kverneland, Peter Kramer, Stanislav Ovroutski
Almost fifty years after its first clinical application, the modified Fontan operation is among the most frequently performed procedures in congenital heart disease surgery in children today. The objective of this review is to systematically summarize the international evolution of outcomes in regard to morbidity and mortality of patients with Fontan palliation. All studies published over the past five decades with more than 100 Fontan patients included were screened. In eligible studies, information concerning preoperative patients' characteristics, Fontan modifications employed, early mortality, long-term survival and frequency of relevant complications was extracted...
January 25, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29368430/fetal-heart-size-measurements-as-new-predictors-of-homozygous-%C3%AE-thalassemia-1-in-mid-pregnancy
#15
Xinyan Li, Xiaoxia Qiu, Huan Huang, Yili Zhao, Xueqin Li, Meng Li, Xiaoxian Tian
OBJECTIVE: To evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous α-thalassemia-1. DESIGN: Prospective diagnostic study. SETTING: The carrier rate of α-thalassemia-1 (-/αα) in China's Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, the risk of homozygous α-thalassemia-1 in one pregnancy is 25%. PATIENTS: Singleton mid-pregnancies at risk of homozygous α-thalassemia-1 were enrolled...
January 25, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29363266/association-between-maternal-body-mass-index-and-congenital-heart-defects-in-infants-a-meta-analysis
#16
Yu Zhu, Yong Chen, Yu Feng, Di Yu, Xuming Mo
We conducted this meta-analysis to address the open question of a possible association between maternal body mass index (BMI) and congenital heart defects (CHDs) in infants. We conducted a comprehensive computerized search of PubMed, Web of Science, Medline, and Embase databased (January 1980 through August 2017). We assessed the association between maternal BMI and the risk for congenital heart defects in their offspring. Study-specific relative risk estimates were polled according to random-effect or fixed-effect models...
January 23, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29345123/the-effects-of-lifestyle-changes-on-serum-lipid-levels-in-children-in-a-real-life-setting
#17
Angeline D Opina, Constance Cephus, Yunfei Wang, Samuel Younan, Douglas Moodie
OBJECTIVE: Studies have shown improvement in lipid levels after institution of lifestyle changes in children enrolled in closely monitored programs. There programs are difficult to mimic in real world clinics. We aim to determine if diet and exercise result in improvement in lipid levels in patients seen in a designated lipid clinic in a real life setting. DESIGN: Retrospective review of patients followed for dyslipidemia at the Texas Children's Hospital Lipid Clinic from May 1, 2012 to May 1, 2015...
January 18, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29316261/arrhythmia-after-cone-repair-for-ebstein-anomaly-the-mayo-clinic-experience-in-143-young-patients
#18
Philip Wackel, Bryan Cannon, Joseph Dearani, Kristen Sessions, Kimberly Holst, Jonathan Johnson, Frank Cetta
BACKGROUND: The increased incidence of preoperative and postoperative arrhythmia in Ebstein anomaly (EA) prompted some clinicians to perform an electrophysiology study (EPS) in all patients prior to surgery for EA. The cone repair (CR) is the current surgical option of choice for most young patients with EA but the effect of the CR on arrhythmia is not well established. OBJECTIVES: To assess the burden of arrhythmia in young patients after CR and to assess the utility of selective preoperative EPS...
January 8, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29314646/right-ventricular-contractile-reserve-in-tetralogy-of-fallot-patients-with-pulmonary-regurgitation
#19
Clotilde Kingsley, Saad Ahmad, John Pappachan, Sujata Khambekar, Thomas Smith, Diane Gardiner, James Shambrook, Shankar Baskar, Ryan Moore, Gruschen Veldtman
BACKGROUND: The right ventricular (RV) contractile reserve is a measure of the dynamic function of the RV and is a sensitive indicator of volume load. This can be measured noninvasively using the tricuspid annular plane systolic excursion (TAPSE) during exercise. We studied the RV contractile reserve of patients after tetralogy of Fallot (TOF) repair with varying degree of RV dilation and pulmonary regurgitation (PR), and compared them to a control group. METHODS: Twenty-six patients who had undergone TOF repair (mean age 29 ± 10 years) were identified and stratified into three group based on the presence and severity of RV dilation and PR...
January 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29280293/subclinical-hypothyroidism-a-common-finding-in-adult-patients-with-cyanotic-congenital-heart-disease
#20
Peter Bak, Cristel S Hjortshøj, Peter Gaede, Lars Idorn, Lars Søndergaard, Annette S Jensen
OBJECTIVE: Cyanotic congenital heart disease is a systemic disease, with effects on multiple organ systems. A high prevalence of subclinical hypothyroidism (SCH) has been reported in a small cohort of cyanotic congenital heart disease patients. Subclinical hypothyroidism has been associated with various adverse cardiovascular effects, as well as an increased risk of progression to overt hypothyroidism. The aim of this study was to examine the prevalence of SCH in cyanotic congenital heart disease patients, consider possible etiologies, and evaluate thyroid function over time...
December 27, 2017: Congenital Heart Disease
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