Yang Liu, Yan-Song Han, Jin-Feng Wang, Zhong-Qi Pang, Jian-She Wang, Lu Zhang, Jia-Xin He, Lin-Kun Shen, Bo Ji, Bei-Chen Ding, Ming-Hua Ren
BACKGROUND: The biological roles of immune-related genes (IRGs) in bladder cancer (BC) need to be further elucidated. OBJECTIVE: To elucidate the predictive value of IRGs for prognosis and immune escape in BC. METHODS: We comprehensively analyzed the transcriptomic and clinical information of 430 cases, including 19 normal and 411 BC patients from the TCGA database, and verified 165 BC cases in the GSE13507 dataset. The risk model was constructed based on IRGs by applying LASSO Cox regression and exploring the relationship between the risk score and prognosis, gene mutations, and immune escape in BC patients...
November 7, 2023: Cancer Biomarkers: Section A of Disease Markers