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Cancer Biomarkers: Section A of Disease Markers

Ping Luo, Wei Jing, Man Zhu, Nan-Di Li, Hu Zhou, Ming-Xia Yu, Chun-Zi Liang, Jian-Cheng Tu
BACKGROUND: Hepatocellular carcinoma (HCC), is an extremely aggressive malignancy with poor prognosis and high fatality rates worldwide. Accumulating evidence indicated that novel biomarkers are required to get a better understanding of the biological mechanisms of HCC. SRA1, a long non-coding RNA (lncRNA), serves as a critical regulator in several cancers. However, the association between SRA1 expression and tumorigenesis in HCC tissues remains unclear. OBJECTIVE: In the present study, we evaluated the expression of SRA1 in HCC and its clinical association...
January 3, 2017: Cancer Biomarkers: Section A of Disease Markers
Rustam Heydarov, Sergei Titov, Mikhail Abramov, Edward Timofeev, Vladimir Mikhailovich
BACKGROUND: Improving the efficacy of anticancer therapy remains an urgent and very important task. Screening of the individual genetic metabolism of cancer patients allows for prescribing adequate medication in the correct dose as well as for decreasing side effects associated with drug toxicity. OBJECTIVE: Estimation of a microarray-based method for genotyping of the UGT1A1, DPYD, GSTP1, and ABCB1 metabolic regulation genes to evaluate for an increased risk of toxicity of anticancer drugs...
January 3, 2017: Cancer Biomarkers: Section A of Disease Markers
Xianjuan Shen, Yan Zhang, Xian Wu, Yuehua Guo, Wei Shi, Jing Qi, Hui Cong, Xudong Wang, Xinhua Wu, Shaoqing Ju
OBJECTIVE: The purpose of this study was to explore serum PCAT-1 expression in multiple myeloma (MM) and examine the potential usefulness of this molecule as a biomarker for diagnosis in MM. METHODS: Serum samples were collected from 60 newly diagnosed untreated MM patients, and 48 healthy controls. Serum PCAT-1 expression levels were detected by RT-qPCR. In addition, correlations between the relative expression of serum PCAT-1 and the concentrations of lactic acid dehydrogenase (LDH), β2M, λ light chain and κ light chain were assessed...
January 3, 2017: Cancer Biomarkers: Section A of Disease Markers
Guo-Jian Li, Qin-Yan Chen, Tim J Harrison, Xue-Yan Wang, Li-Ping Hu, Qing-Li Yang, Kai-Wen Li, Zhong-Liao Fang
BACKGROUND: The accuracy of des-γ -carboxyprothrombin (DCP) in the detection of hepatocellular carcinoma (HCC) in those infected hepatitis B virus (HBV) from cross-sectional or case-control studies are contradictory. OBJECTIVE: To resolve this contradiction using a prospective study. METHODS: Three hundreds male individuals persistently infected with HBV were recruited from the Chinese cohort and followed up once per year from 2012 to 2015...
January 3, 2017: Cancer Biomarkers: Section A of Disease Markers
Kai Huang, Jun Chen, Mo-Song Yang, Yu-Jun Tang, Feng Pan
Chondrosarcomas are malignant cartilage-forming tumors from low-grade to high-grade aggressive tumors characterized by metastasis. Cisplatin is an effective DNA-damaging anti-tumor agent for the treatment against a wide variety of solid tumors. However, chondrosarcomas are notorious for their resistance to conventional chemo- and radio- therapies. In this study, we report miR-23b acts as a tumor suppressor in chondrosarcoma. The expressions of miR-23b are down-regulated in chondrosarcoma patient samples and cell lines compared with adjacent normal tissues and human primary chondrocytes...
January 3, 2017: Cancer Biomarkers: Section A of Disease Markers
Jianxia Hu, Chengqian Li, Chongkai Liu, Shihua Zhao, Yangang Wang, Zhengju Fu
BACKGROUND: The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low, it is essential to develop novel diagnostic and prognostic biomarkers for PTC. OBJECTIVE: To explore the expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues and plasma and their associations with the clinical characteristics of PTC. METHODS: We investigated the expressions of miR-940, miR-15a, miR-16 and IL-23 in plasma and thyroid tissues of PTC, nodular goiter and healthy people with qRT-PCR, and further analyzed the associations between their levels and the clinical characteristics of PTC...
December 30, 2016: Cancer Biomarkers: Section A of Disease Markers
Yunsheng Guo, Yan Pang, Xia Gao, Min Zhao, Xin Zhang, Hao Zhang, Bing Xuan, Yimin Wang
The mechanisms underlying oxaliplatin (OXA) resistance in colon cancer cells are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. However, the relationship between miRNA and OXA resistance in colon cancer cells has not been previously explored. In this study, we utilized microRNA microarray analysis and real-time PCR to verify that miR-93, miR-191, miR-137, miR-181 and miR-491-3p were significantly down-regulated and that miR-96, miR-21, miR-22, miR-15b and miR-92 were up-regulated in both HCT-15/OXA and SW480/OXA cell lines...
December 23, 2016: Cancer Biomarkers: Section A of Disease Markers
Neslihan Kurtul, Erdem Arzu Taşdemir, Dilek Ünal, Mustafa İzmirli, Celalettin Eroglu
BACKGROUND: The aim of this study is to search the prognostic value of SPARC expression in rectum cancer cases receiving postoperative radiotherapy. METHODS: Forty three rectal cancer patients are recruited to this retrospective study. All patients received postoperative radiotherapy which the median dose was 5040 cGy and concomitant chemotherapy. Samples taken from their paraffin blocks were examined with immunohistochemical procedures. RESULTS: When the association between SPARC expression and the clinicopathological feature was examined, there was a significant association between age and expression levels...
December 16, 2016: Cancer Biomarkers: Section A of Disease Markers
Anna Caliò, Emilio Bria, Sara Pilotto, Eliana Gilioli, Alessia Nottegar, Albino Eccher, Luca Cima, Antonio Santo, Serena Pedron, Giona Turri, Sakari Knuutila, Marco Chilosi, Francesca Vanzo, Giuseppe Bogina, Alberto Terzi, Giampaolo Tortora, Aldo Scarpa, Massimo Loda, Guido Martignoni, Matteo Brunelli
BACKGROUND: Gains of a gene due to DNA polyploidy versus amplification of the specific locus are distinct molecular alterations in tumors. OBJECTIVE: We quantified copy number gains of ALK gene due to unspecific polyploidy versus amplifications of the specific locus in a series of non-small cell lung cancers. METHODS: The locus specific ALK copy (LSI) number status was evaluated in 205 cases by FISH. Ratio LSI ALK copy number corrected for control probes CEP2, CEP3 and CEP17 (CEPs) was scored...
December 16, 2016: Cancer Biomarkers: Section A of Disease Markers
Dingyuan Luo, Haibo Chen, Penghui Lu, Xiaojuan Li, Miaoyun Long, Xinzhi Peng, Mingqing Huang, Kai Huang, Shaojian Lin, Langping Tan, Yue Zhu, Zhibo Chen, Nengtai Ouyang, Honghao Li
OBJECTIVE: In this study, we examined the relationships between the expression level of CHI3L1 and the clinicopathological characteristics of papillary thyroid carcinoma. METHODS: A total of 322 tissue samples from patients with papillary thyroid carcinoma were collected, and the CHI3L1 expression levels in tumor tissues, matched adjacent noncancerous tissues were detected using immunohistochemistry (IHC) and qRT-PCR. The relationships between CHI3L1 expression levels and the clinical characteristics were evaluated...
December 16, 2016: Cancer Biomarkers: Section A of Disease Markers
Zhao-Yang Yang, Fang Yang, Ying-Li Zhang, Bao Liu, Meng Wang, Xuan Hong, Yan Yu, Yao-Hui Zhou, Hai Zeng
Our study aimed to explore the effects of long noncoding RNA (lncRNA)-ANCR on the invasion and migration of colorectal cancer (CRC) cells by regulating enhancer of zeste homolog 2 (EZH2) expression. CRC tissues and adjacent normal tissues were collected and CRC SW620 cells line and normal human intestinal epithelial cells (HIECs) were incubated. CRC SW620 cells line was transfected with ANCR-siRNA. The expressions of ANCR and EZH2 mRNA were measured by real-time quantitative polymerase chain reaction (RT-qPCR)...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Kewei Ma, Wang Xu, Chang Wang, Biao Li, Keju Su, Wei Li
OBJECTIVES: This study aimed to examine the prognostic role of the plasma 25-hydroxyvitamin D (25(OH)D) level in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet first-line chemotherapy. METHODS: A total of 195 advanced NSCLC patients were consecutively and prospectively hospitalized to receive platinum-based first-line chemotherapy. The baseline 25(OH)D level was measured at the time of diagnosis. Main outcome measures included overall survival (OS) and progression-free survival (PFS)...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Fan Chen, Xin-Feng Li, Dong-Sheng Fu, Jian-Guo Huang, Shun-E Yang
miRNA-221 is one of the over 700 kinds of currently known microRNAs (miRNAs) and is up-regulated in multiple tumors, suggesting that it may be a potential carcinogenic miRNA. Few studies have explored the relationship between miRNA-221 and hepatocellular carcinoma (HCC). We performed real-time quantitative polymerase chain reaction (qPCR) to detect miRNA-221 expression in HCC and para-carcinoma tissues and to explore the relationship between abnormal expression of miRNA-221 and clinicopathological features of HCC patients...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Nadezda Cherdyntseva, Polina Gervas, Elena Voropaeva, Evgeny Denisov, Lubov Pisareva, Elena Malinovskaya, Vladimir Maksimov, Michail Voevoda, Dmitriy Perinov, Yelena Panferova, Evgeny Cherdyntsev, Evgeny Choynzonov
BACKGROUND: The BRCA1 mutations that are endemic to the Slavic population of Russia have not been identified among indigenous peoples, including the Buryats, Tuvinians and Altaians with hereditary breast cancer. OBJECTIVE: This study was aimed to identify the mutations that are responsible for the occurrence of hereditary breast cancer in the indigenous population of the Republic of Buryatia. METHODS: Mutations in the BRCA1 gene were identified in blood samples by Sanger-based sequencing...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Flávia S Donaires, Paulo R D V Godoy, Giovana S Leandro, Elza T Sakamoto-Hojo
BACKGROUND: Glioblastoma corresponds to the most common and malignant brain tumor in adults. Patients have a median survival of approximately one year from diagnosis due to poor response to therapy. OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in an attempt to point out molecular targets for therapy. METHODS: Up-regulated genes in glioblastoma selected from public microarray data were submitted to two TF association analyses...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Xiaorong Yan, Dezhi Kang, Jun Pan, Changzhen Jiang, Yuanxiang Lin, Songtao Qi
BACKGROUND: The calcification of adamantinomatous craniopharyngioma (ACP) often creates difficulties for surgical therapy. Nevertheless, the mechanism of ACP calcification is unclear. Our previous studies demonstrated that osteoblastic factors might play important roles in ACP calcification. OBJECTIVE: We examined the effects of recombinant human Bmp2 on ACP cell differentiation by testing osteoblastic proteins and calcium deposition. METHODS: The expression of osteoblastic factors including osteopontin (OPN), Runx2, and osterix in Bmp2-treated ACP cells was examined by western blot and/or real time PCR...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Xu-Hui Huang, Rong-Hua Liang, Le Su, Wei Guo, Chang-Jun Wang
PURPOSE: Research on the mechanism of Bushen Jianpi decoction (BJD) for preventing and treating osteoporosis caused by aromatase inhibitors (AI) during treatment for breast cancer resection. METHODS: An ovariectomized mouse model was established using random division into 6 groups: a sham ovariectomized group, a blank control group, a control group, an alendronate group, a BJD group, and a drug combination group. Mice breast cancer cell lines (4T1) were cultured and seeded into the armpits of 6 groups of BALB/c mice...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Rania A Zayed, Maha A Eltaweel, Shahira K A Botros, Mohamed A Zaki
OBJECTIVE: Multiple genetic alterations with prognostic significance have been discovered in acute myeloid leukemia (AML). We studied the expression level of two genes, Meningioma1 (MN1) and Phosphatase and Tensin homolog (PTEN) to determine their expression in AML patients and their role as prognostic markers. METHODS: The study included 50 cytogenetic normal de novo AML cases and 10 controls, Their level was detected by Real time Reverse Transcription-Polymerase Chain Reaction...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Jun Han, Qingyang Meng, Qiulei Xi, Haiyu Wang, Guohao Wu
OBJECTIVE: Gastric cancer is one of the most common cancers worldwide, and the prognosis is still very poor due to the lack of specific and sensitive biomarkers. Aerobic glycolysis is one of the critical hallmarks of gastric cancer cells, and several glycolytic enzymes are highly expressed in gastric cancer patients. However, the expression and clinical significances of phosphofructokinase-2/fructose-2,6-bisphosphatase3 (PFKFB3, one of the glycolytic enzymes) in a large sample of gastric cancer patients remain unclear...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Andrés Felipe Aristizabal-Pachon, Willian Orlando Castillo
BACKGROUND: Breast cancer is one of the principal causes of death among Brazilian women, so it is a challenge to find new and specific early diagnostic markers, using simple and fast procedures. GSK3β gene is an important Wnt signaling regulator involved in β-Catenin degradation. Wnt signaling is associated with initiation and progression process in many tumor types, and alterations in β-Catenin explain only a small proportion of aberrant signaling found in breast cancer, indicating that other Wnt signaling components and/or regulators as GSK3β may be involved...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
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