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Cancer Biomarkers: Section A of Disease Markers

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https://www.readbyqxmd.com/read/30347603/the-effect-of-high-intensity-focused-ultrasound-on-the-treatment-of-liver-cancer-and-patients-immunity
#1
Baofeng Ma, Xiaoming Liu, Zhaoxiao Yu
OBJECTIVE: To investigate the effects of high intensity focused ultrasound on liver function, tumor markers and survival rate of hepatocellular carcinoma patients. METHODS: Ninety six cases with primary liver cancer patients, consisting of 66 males and 30 females, were enrolled in this study and treated with high intensity focused ultrasound combined with stereotactic segmentation dose radiation, low frequency for 10 times, followed by analysis of KPS score of liver cancer, Child-Pugh, grading and staging of liver cancer, 3 months, 6 months, 1 year of clinical symptom remission rate, tumor markers, liver function, survival rate, as well as the change of immune related cytokines...
October 9, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347601/nup153-overexpression-suppresses-the-proliferation-of-colorectal-cancer-by-negatively-regulating-wnt-%C3%AE-catenin-signaling-pathway-and-predicts-good-prognosis
#2
Yibin Wu, Guojiu Fang, Xin Wang, Huipeng Wang, Wenjie Chen, Liang Li, Tao Ye, Lifeng Gong, Chongwei Ke, Yuankun Cai
BACKGROUND: Nucleoporin NUP153 (NUP153) is well known to be involved in the regulating of nuclear transport. Although NUP153 is associated with several cancers, its role in colorectal cancer (CRC) and the underlying mechanism are still unknown. OBJECTIVE: The aim of this study was to access the effect of NUP153 on the prognosis of patients with CRC, and cancer cell proliferation. METHODS: The expression levels of NUP153 in CRC tissues and matched normal colon tissues were examined by real-time quantitative PCR and immunohistochemistry...
October 9, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347594/erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
October 9, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347602/the-diagnostic-effect-of-serum-mir-139-5p-as-an-indicator-in-osteosarcoma
#4
Lei Zhou, Xiao Ma, Jian Yue, Tong Chen, Xin-Yang Wang, Zhi-Wei Wang, Jiang Pan, Yuan Lin
BACKGROUND: The microRNA, miR-139-5p, plays an important role in the initiation and progression of various tumor types including osteosarcoma (OS). OBJECTIVE: This study aimed to detect the serum miR-139-5p expression in OS and analyze its association with clinical variables. METHODS: Blood samples were taken from 98 OS patients and 50 healthy individuals, and serum miR-139-5p levels were measured by quantitative reverse transcription-polymerase chain reaction...
September 26, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347600/annexina7-down-regulation-might-suppress-the-proliferation-and-metastasis-of-human-hepatocellular-carcinoma-cells-via-mapk-erk-pathway
#5
Yina Zhao, Qiang Yang, Xiaojie Wang, Wenyi Ma, Huanna Tian, Xiujun Liang, Xin Li
BACKGROUND: Hepatocellular carcinoma is one of the most fatal malignancies worldwide with high lethality. However, the exact mechanism of liver tumorigenesis is still unclear. AnnexinA7 (ANXA7) is a Ca2+-binding protein which is involved in membrane organization and dynamics and indicated a role of ANXA7 in cancer. However, the action of ANXA7 in hepatocellular carcinoma and the relative mechanism is still indistinct. OBJECTIVE: To gain more insight into the biological function of ANXA7 and assess its possible influence on proliferation and metastasis capacity of human hepatocellular carcinoma cells with the relative mechanism...
September 26, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347599/circ-itch-correlates-with-small-tumor-size-decreased-figo-stage-and-prolonged-overall-survival-and-it-inhibits-cells-proliferation-while-promotes-cells-apoptosis-in-epithelial-ovarian-cancer
#6
Ling Luo, Yuqiang Gao, Xiaofeng Sun
OBJECTIVE: The aim of this study was to evaluate the correlation of circular RNA itchy E3 ubiquitin protein ligase (Circ-ITCH) expression with clinicopathological features and survival in patients with epithelial ovarian cancer (EOC), and to explore its effect on cells proliferation as well as apoptosis in EOC cells. METHODS: Seventy-seven EOC patients underwent surgery were retrospectively reviewed. Tumor tissues and paired adjacent tissues samples were collected, and Circ-ITCH expression was evaluated by quantitative polymerase chain reaction (qPCR)...
September 26, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347598/cd45-correlates-with-adverse-risk-stratification-decreased-treatment-response-and-unfavorable-survival-profiles-in-elderly-acute-myeloid-leukemia-patients
#7
Liyin Guo, Li Chen, Hongxiang Wang
OBJECTIVE: This study aimed to explore the correlation of CD45 expression with clinicopathological features and treatment outcomes in elderly acute myeloid leukemia (AML) patients. METHODS: One hundred and twenty one elderly patients with de novo AML were consecutively recruited in this prospective cohort study, bone marrow samples from all patients were collected and CD45 expression were measured with flow cytometry. Complete remission (CR), event-free survival (EFS) and overall survival (OS) were evaluated...
September 26, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347597/downregulation-of-long-noncoding-rna-pvt1-attenuates-paclitaxel-resistance-in-glioma-cells
#8
Tiejun Song, Lei Yan, Kerui Cai, Tianshu Zhao, Meiling Xu
BACKGROUND: Drug resistance in clinical cancer treatment has become an issue. OBJECTIVE: We focus on abnormally expressed lncRNAs in glioma and investigating the function of PVT1. METHODS: The paclitaxel-resistant glioma cells SHG-44 RE was obtained through screening the SHG 44 cells that were cultured in medium containing a certain concentration of paclitaxel. Cell survival of SHG 44 RE and SHG 44 cells under the treatment of paclitaxel was detected by MTT assay...
September 25, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347596/identification-of-crucial-genes-and-prediction-of-small-molecules-for-multidrug-resistance-of-hodgkin-s-lymphomas
#9
Yi Huang, Yu Huang, Liang Zhang, Aoshuang Chang, Peng Zhao, Xiao Chai, Jishi Wang
BACKGROUND: Multidrug resistance of Hodgkin's lymphoma (HL) often results in recurrence. Thus, we aimed to explore the underlying molecular mechanisms of multidrug resistance using bioinformatics strategies. METHODS: The gene expression profile was obtained from GEO database. Then, the differentially expressed genes were screened out, and their functional annotations were carried out. Then, gene-signal interaction network was constructed and Connectivity Map (CMAP) analysis was performed...
September 25, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30347595/long-non-coding-rna-taurine-upregulated-gene-1-correlates-with-unfavorable-prognosis-in-patients-with-refractory-or-relapsed-acute-myeloid-leukemia-treated-by-purine-analogue-based-chemotherapy-regimens
#10
Wenfeng Luo, Huilan Yu, Xingli Zou, Xun Ni, Jin Wei
OBJECTIVE: This study aimed to explore the correlation of long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) expression with clinicopathological features and its predictive value for treatment response and survival profiles in refractory or relapsed acute myeloid leukemia (R/R AML) patients. METHODS: Seventy three R/R AML patients who received cladribine combined with cytarabine and granulocyte colony-stimulating factor (G-CSF) (CLAG) or fludarabine combined with cytarabine and G-CSF (FLAG) based chemotherapy and 37 non-malignant controls were recruited...
September 25, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30248047/mir-126-an-indicator-of-poor-prognosis-and-recurrence-in-histologically-lymph-node-negative-gastric-cancer
#11
Runhua Feng, Birendra K Sah, Jianfang Li, Sheng Lu, Fei Yuan, Xiaolong Jin, Min Yan, Bingya Liu, Chen Li, Zhenggang Zhu
BACKGROUND: Few biomarkers are available for the prediction of prognosis and recurrence in lymph node (LN)-negative gastric cancer (GC) currently. miR-126 functions as a tumor suppressor in GC, however, its clinical significance in LN-negative GC remains unknown. AIM: To investigate the associations of tissue miR-126 level with the clinicopathological characteristics and clinical outcome of LN-negative GC patients. METHODS: Quantitative real-time polymerase chain reaction was performed to examine the tissue miR-126 level in 315 LN-negative GC patients who underwent curative gastrectomy with D2 lymphadenectomy...
September 10, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223387/soluble-lag3-acts-as-a-potential-prognostic-marker-of-gastric-cancer-and-its-positive-correlation-with-cd8-t-cell-frequency-and-secretion-of-il-12-and-inf-%C3%AE-in-peripheral-blood
#12
Na Li, Bulibu Jilisihan, Wei Wang, Yong Tang, Saifuding Keyoumu
OBJECTIVE: Gastric cancer (GC) is the second most common lethal cancer worldwide and lymphocyte-activation gene 3 (LAG3) as a therapeutic target for cancers has been investigated. Herein, our study is to clarify the value of peripheral blood (PB) soluble LAG-3 (sLAG3) in GC. METHODS: Peripheral serum samples of GC patients and healthy people were collected for the measurement of serum levels of sLAG3, carcinoembryonic antigen (CEA), IL-12 and IFN-γ. Additionally, ROC and Kaplan-Meier curves were adopted to identify the diagnostic and prognostic values of sLAG-3 in patients with GC...
September 7, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30248046/the-clinicopathological-significance-of-cd133-and-sox2-in-astrocytic-glioma
#13
Aziza E Abdelrahman, Hanaa M Ibrahim, Eman A Elsebai, Eman I Ismail, Wael Elmesallamy
BACKGROUND: The treatment strategies of astrocytoma have not changed considerably due to the restricted appreciation of its biology. OBJECTIVES: This study aimed to evaluate the expression of the stem cell-related proteins (CD133 and Sox2) and their prognostic value in astrocytic glioma. METHODS: The immunohistochemical expression of CD133 and Sox2 in 40 patients with an astrocytic glioma of different grades was studied. The recorded data on the overall survival (OS), progression-free survival (PFS) and the response to the therapeutic protocol were collected and lastly analyzed...
September 6, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30248045/attenuated-total-reflectance-spectroscopy-to-diagnose-skin-cancer-and-to-distinguish-different-metastatic-potential-of-melanoma-cell
#14
Farah Andleeb, Atia Atiq, Maria Atiq, Sadia Malik
Early diagnosing of skin cancer and investigation of metastatic potential of cancer cells are very important to treat it appropriately. Infrared spectroscopy of biological tissues is an emerging technique which gives the spectral differences between healthy and diseased cells. In this work, we have demonstrated that attenuated total reflectance Fourier transform (ATR-FTIR) spectroscopy can be used in diagnostic of skin cancer and in differentiating metastatic potential of cancer cells. Using IR spectroscopy, we can identify various types of cancer such as basal cell carcinoma, malignant melanoma, nevus and metastatic potential by alternations in hydration level and molecular changes...
September 6, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30248044/upregulated-ffar4-correlates-with-the-epithelial-mesenchymal-transition-and-an-unfavorable-prognosis-in-human-cholangiocarcinoma
#15
Fu-Tao Meng, Mei Huang, Feng Shao, Qiang Huang
BACKGROUND: Free fatty acid receptor 4 (FFAR4) is associated with the epithelial mesenchymal transition (EMT) and is involved in the progression of several types of cancer. However, the role of FFAR4 in cholangiocarcinoma (CCA) remains unclear. OBJECTIVE: The present study evaluated the diagnosis and prognosis of CCA using FFAR4 as a biomarker. METHODS: Immunohistochemistry was employed to detect expression of FFAR4 in 98 samples of CCA tissues and adjacent tissues...
September 4, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223389/ubiquitin-specific-protease-22-promotes-the-proliferation-migration-and-invasion-of-glioma-cells
#16
Jun Liang, Xian-Li Zhang, Shun Li, Shao Xie, Wei-Feng Wang, Ru-Tong Yu
Ubiquitin-specific protease 22 (USP22), as one of the 11 death-from-cancer signature genes, presented high expression in a variety of tumors. Previous studies showed that USP22 played a significant role in cell-cycle, oncogenesis, clinicopathology and survival. Our studies have presented USP22 was over-expressed in glioma tissue and the patients with high expression of USP22 had a poor survival than that with low expression of USP22. However, the concrete effect of USP22 on biological behavior in glioma cells has been rarely reported...
September 3, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223392/comparison-of-circulating-dna-from-plasma-and-urine-for-egfr-mutations-in-nsclc-patients
#17
Hao Zhang, Bin He, Jun Cui, Mingzhang Zhao, Zengwang Zhang
PURPOSE: The need for less invasive procedures for lung cancer probing is critically needed to better understand the disease. The purpose of the current study aims to explore the use of circulating tumor DNA (ctDNA) derived from plasma and urine specimens. METHODS: Matched peripheral blood and morning urine specimens were obtained from 160 late stage NSCLC patients. The amount of ctDNA was quantified for each of the patients. Activating and sensitizing EGFR mutations commonly found in NSCLC patients were profiled...
September 2, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223391/contribution-of-smoking-habit-to-the-prognosis-of-stage-i-kras-mutated-non-small-cell-lung-cancer
#18
Hiroaki Kuroda, Tatsuya Yoshida, Takaaki Arimura, Tetsuya Mizuno, Noriaki Sakakura, Yasushi Yatabe, Yukinori Sakao
BACKGROUND: One of the known risk factors for non-small cell lung cancer (NSCLC) is somatic mutation in the Kirsten rat sarcoma (KRAS) gene. The relationship with smoking is well known. METHODS: We retrospectively studied the data of 92 patients who underwent pulmonary resection January 2003 and June 2012 and were diagnosed as KRAS-mutated pathological stage I adenocarcinoma. RESULTS: Among them, 33 patients who were non to light smoker (NLS) (smoking index, 0 to 400) were compared with 59 middle to heavy smoker (MHS) (> 400)...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223390/downregulated-gbx2-gene-suppresses-proliferation-invasion-and-angiogenesis-of-breast-cancer-cells-through-inhibiting-the-wnt-%C3%AE-catenin-signaling-pathway
#19
Ying Fang, Yuan Yuan, Li-Li Zhang, Jian-Wei Lu, Ji-Feng Feng, Sai-Nan Hu
OBJECTIVE: Gastrulation brain homeobox 2 (GBX2), a gene involved in mid/hindbrain region, has been revealed as one of the oncogene associated with certain cancers, as an example being prostate cancer. However, despite years of worldwide research, the underlying mechanism of GBX2 as well as its significance in breast cancer still remains unclear. Therefore, the present study evaluates the abilities of GBX gene silencing providing for the proliferation, invasion and angiogenesis of breast cancer cells by way of the Wnt/β-catenin signaling pathway...
August 29, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30223388/katanin-p80-expression-correlates-with-lymph-node-metastasis-and-worse-overall-survival-in-patients-with-breast-cancer
#20
Xun Li, Jie Liu, Peng-Fei Shi, Peng Fu
OBJECTIVE: The aim of this study was to investigate the correlation of katanin P80 expression with clinicopathological features and overall survival (OS) in surgical breast cancer (BC) patients. METHODS: Four hundred and fourteen BC patients underwent surgery were analyzed in this retrospective cohort study. Katanin P80 expression was examined by immunofluorescence assay. The median follow-up duration was 118.0 months (quantiles: 99.0-140.5 months), the last follow-up date was Jul 1st 2017...
August 29, 2018: Cancer Biomarkers: Section A of Disease Markers
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