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Cancer Biomarkers: Section A of Disease Markers

Hongliang Yao, Zhulin Yang, Ziru Liu, Xiongying Miao, Leping Yang, Daiqiang Li, Qiong Zou, Yuan Yuan
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with metastasis in most patients at diagnosis. The molecular mechanisms associated with its high malignancy have not been fully elucidated. This study investigated the clinicopathological significances of GPC3 and KRT19 expression in PDAC. METHODS: GPC3, KRT19, and CA19-9 protein expression were measured by immunohistochemistry. RESULTS: GPC3 and KRT19 protein levels were overexpressed in PDAC tumors compared to normal pancreatic tissues, benign pancreatic tissues, and peritumoral tissues (P< 0...
September 22, 2016: Cancer Biomarkers: Section A of Disease Markers
Jueru Zheng, Jianjun Li
OBJECTIVE: To investigate the potential role of serum miR-203 as noninvasive recurrence-predictive and prognostic biomarker in patients with papillary thyroid carcinoma (PTC). METHODS: One hundred and sixty-five patients scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO. 2 hospital from June, 2003 to September, 2006 were enrolled in this study. Serum expressions of miR-203 were evaluated from the obtained blood samples from all the PTC patients by quantitative real-time PCR...
September 20, 2016: Cancer Biomarkers: Section A of Disease Markers
Hai-Su Yang
BACKGROUND: Hematopoietic malignancies are a group of blood cell disorders characterized by abnormal hematopoietic proliferation. OBJECTIVE: The identification of specific clinicopathologic characteristics and tumor-related gene status provides critical information on potential therapeutic targets. METHODS: The specimens were tested with immunohistochemistry, flow cytometry, RT-PCR and fragment analysis. RESULTS: In this study, a patient with a long history of tobacco use was reported with a diagnosis of simultaneous low-grade B-cell lymphoproliferative disorder (LPD) and myeloproliferative neoplasm (MPN)...
September 18, 2016: Cancer Biomarkers: Section A of Disease Markers
Shu-Xia Li, Yan-Qi Yang, Li-Jian Jin, Zhi-Gang Cai, Zheng Sun
INTRODUCTION: The aim of this study was to detect the survivin, carcinoembryonic antigen (CEA) and ErbB2 in the saliva, serum and local tumor-exfoliated cells of oral squamous cell carcinoma (OSCC) patients, for providing reliable tumor markers for the early detection of oral malignant cancer. MATERIALS AND METHODS: The saliva, serum, and local tumor-exfoliated cell samples of 26 OSCC patients without chemotherapy and 10 non-cancer patients were collected in Department of Oral and Maxillofacial Surgery, School of Stomatology, Peking University...
September 16, 2016: Cancer Biomarkers: Section A of Disease Markers
Juan Wang, Shufang Zhang, Weihua Ni, Xiaoyu Zhai, Fei Xie, Hongyan Yuan, Sujun Gao, Guixiang Tai
BACKGROUND: Mucin 1 (MUC1), as an oncogene, plays an important role in the diagnosis of lung cancer. OBJECTIVE: To establish a double-antibody sandwich enzyme-linked immune sorbent assay (ELISA) kit for the detection of serum MUC1 in lung cancer patients. METHODS: Commercial mouse anti-human MUC1 monoclonal antibody and rabbit anti-human MUC1 polyclonal antibody were used to construct a double-antibody sandwich ELISA kit. The serum MUC1 levels in peripheral blood of lung disease patients and healthy individuals were detected by the double-antibody sandwich ELISA kit and CA15-3 kit, respectively...
September 9, 2016: Cancer Biomarkers: Section A of Disease Markers
Long Gong, Ying Xu, Ya-Qin Hu, Qiu-Ju Ding, Chun-Hua Yi, Wei Huang, Ming Zhou
OBJECTIVES: The study explored the association between rs10069690C/T and rs2736100G/T of human telomerase reverse transcriptase (hTERT) gene, and the prognosis of thyroid cancer. METHODS: The study had 452 thyroid cancer patients recruited as case group who hospitalized in Jingzhou Central Hospital from January 2001 to June 2004 and 452 healthy people recruited as control group at the same area. The hTERT gene polymorphisms at rs10069690 C/T and rs2736100 G/T were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Lei Xu, Xin Zhou, Jian Wang, Wei Zhu, Ping Liu
BACKGROUND: Recently, many studies have investigated the value of the hematologic markers in the prognosis of gastric cancer (GC). However, most studies only focused on the pre-operative markers. The aim of this study was to investigate the prognostic value of the hematologic markers of resectable GC patients at three different periods of the treatment (preoperative, postoperative and before the first chemotherapy). METHODS: Clinical data from 451 GC patients were retrospectively collected...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Shirin Shahbazi, Maryam Khorasani, Reza Mahdian
OBJECTIVES: The ectopic expression of coagulation Factor VII has been shown in various cancers. Recently, F7 gene has been identified as a direct target of the androgen receptor in breast cancer. In this study, we examined the mRNA expression of F7 and AR in clinical sample series of prostate cancer and BPH. MATERIAL AND METHODS: All the prostate cancer patients were new cases with no medical history of surgery or chemotherapy. The tissue samples were assigned as either prostate cancer tumor (n= 45) harboring at least 80% tumor cell content, or BPH (n= 36)...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Júlia Plentz Portich, Mirela Severo Gil, Rafael Pereira Dos Santos, Bruno Kilpp Goulart, Maria Beatriz Cardoso Ferreira, Jiseh Fagundes Loss, Lauro José Gregianin, Algemir Lunardi Brunetto, André Tesainer Brunetto, Rafael Roesler, Caroline Brunetto de Farias
BACKGROUND: Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related receptor kinase B (TrkB) are involved in the maturation of B lymphocytes in the bone marrow (BM), promote cell differentiation in B-cell malignancies, and are associated with poor prognosis in adults with acute leukemia (AL). However, the role of BDNF in pediatric AL remains poorly understood. OBJECTIVE: We carried out a cohort observational study to evaluate BDNF levels in BM or peripheral blood (PB) samples from children with AL...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Vincenzo Formica, Cristina Morelli, Patrizia Ferroni, Antonella Nardecchia, Manfredi Tesauro, Stefania Pellicori, Vittore Cereda, Antonio Russo, Silvia Riondino, Fiorella Guadagni, Mario Roselli
BACKGROUND: High Neutrophil/Lymphocyte ratio (NLR), as a measure of enhanced inflammatory response, has been negatively associated with prognosis in patients with localized pancreatic ductal adenocarcinoma (PDA). OBJECTIVE: In the present study, we aimed at investigating the prognostic value of NLR in two homogeneous groups of chemotherapy-naïve metastatic PDA patients. Patients were treated with either gemcitabine (GEM) or gemcitabine/oxaliplatin (GEMOXA). We also assessed whether NLR could identify patients benefiting from the use of oxaliplatin...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Jing Yang, Rong Wang, Hongjiang Li, Qing Lv, Wentong Meng, Xiaoqin Yang
BACKGROUND: Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147), a glycoprotein enriched on the plasma membrane of tumor cells, promotes proliferation, invasion, metastasis, and survival of malignant tumor cells. In this study, we sought to examine the expression of EMMPRIN in breast tumors, and to identify the potential roles of EMMPRIN on breast cancer cells. METHODS: EMMPRIN expression in breast cancer tissues was assessed by immunohistochemistry...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Anbang He, Zhicong Chen, Hongbing Mei, Yuchen Liu
OBJECTIVE: In this study, we examined the relationships between the expression level of long non-coding RNA MIR31HG in bladder cancer and the clinical characteristics. METHODS: A total of 55 tissue samples from patients with bladder cancer were collected, and the lncRNA MIR31HG levels in cancer, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR). The relationships between MIR31HG level and the clinical characteristics were evaluated...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Bing Yang, Zheng Liu, Hao Ning, Kai Zhang, Dongliang Pan, Kejia Ding, Wei Huang, Xin-Li Kang, Yang Wang, Xiang Chen
OBJECTIVE: To evaluate the effects of microRNA-21 (miR-21) in peripheral blood mononuclear cells (PBMC) in the diagnosis and prognosis of prostate cancer (PCa). METHODS: Proved by pathologic biopsy, 92 patients diagnosed with PCa and also underwent resection operation and 85 patients with benign prostatic hyperplasia (BPH) were selected in this study, as well as 97 healthy volunteers were chosen as the control group. PBMC were extracted to examine the relative expression of miR-21 by real time reverse transcriptase-polymerase chain reaction (RT-PCR)...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Mahboobeh Meshkat, Hamzeh Mesrian Tanha, Marjan Mojtabavi Naeini, Kamran Ghaedi, Mohammad H Sanati, Marzieh Meshkat, Fatemeh Bagheri
In-silico investigation suggested a common variant within stem of miR-146a-5p precursor (rs2910164, n.60C>G) associated with breast cancer (BC) phenotypes. Our aim was computationally predicting possible targets of miR-146a-5p and probable rs2910164 mechanism of action in expression of phenotypes in BC. Additionally, a case-control study was designated to examine experimentally the correlation of mir-146a rs2910164 variant and BC phenotypes. In this study, 152 BC subjects and healthy controls were genotyped using RFLP-PCR...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Jia-Zhu Wu, Tian Tian, Ying Huang, Jin-Hua Liang, Yi Miao, Li Wang, Ji Xu, Xiao-Yan Qu, Lei Fan, Jian-Yong Li, Wei Xu
BACKGROUND: Carbohydrate antigen 125 (CA-125) is one of the most common used tumor biomarkers in clinical practice. Previous studies showed an association of increased CA-125 levels with advanced characteristics and inferior outcome in non-Hodgkin lymphoma. OBJECTIVE: To identify the clinical significance of CA-125 in diffuse large B-cell lymphoma (DLBCL). METHODS: We retrospectively analyzed 181 patients with DLBCL with measured serum CA-125 concentration at diagnosis and follow-ups during the courses...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
Zuo-Wei Shi, Jing-Lu Wang, Ning Zhao, Ying Guan, Wen He
OBJECTIVE: To study the correlation between single nucleotide polymorphism (SNP) of hsa-miR-124a and risk and prognosis of osteosarcoma (OS). METHODS: OS patients (n = 174) hospitalized at The Second Affiliated Hospital of Harbin Medical University from January 2010 to March 2012 were selected as case group by inclusion and exclusion criteria, and healthy people (n = 150) receiving physical examination at the same duration were recruited as control group. Polymerase chain reaction-ligase detection reaction (PCR-LDR) was performed for genotyping of hsa-miR-124a rs531564...
June 24, 2016: Cancer Biomarkers: Section A of Disease Markers
Kaijiong Zhang, Zhenglian Luo, Yi Zhang, Li Zhang, Lichun Wu, Lian Liu, Jie Yang, Xiaoyu Song, Jinbo Liu
BACKGROUND: Long non-coding RNA (lncRNA) H19 has been well studied playing an important role in breast cancer (BC) progress and the expression of H19 may service as a diagnostic target for BC. However, it is unclear if circulating lncRNA H19 could as a potential biomarker for BC diagnosis and monitor. OBJECTIVE: The objective of our study was to determine whether plasma lncRNA H19 could be used as biomarkers for the screening and early diagnosis of breast cancer...
June 24, 2016: Cancer Biomarkers: Section A of Disease Markers
Liu Yang, Tiejun Wang, Jun Zhang, Zhonghao Liu, Xuxia Wang
BACKGROUND: BTB/POZ domain-containing protein 7 (BTBD7) is recognized as a regulatory gene that regulates epithelial cell dynamics and branching morphogenesis. It is also reported for regulating epithelial-mesenchymal transition (EMT) molecules and involved in the process of invasion and metastasis of lung cancer and hepatocellular carcinoma. Slug is a transcriptional factor of EMT which plays a crucial role in the process of primary salivary adenoid cystic carcinoma (SACC). However, the role of BTBD7 in SACC and the correlation with Slug have not been identified...
June 24, 2016: Cancer Biomarkers: Section A of Disease Markers
Lin Lu, Yuan Shen, Kuo-Fu Tseng, Wenlian Liu, Hui Duan, Wei Meng
BACKGROUND: Endometrial cancer (EC) is a common female malignancy. Most patients were diagnosed at an early stage with a favorable prognosis. But more than 30% patients were high risk at III/IV stage with invading deep into the myometrium and progressively lead to local or extra pelvic metastasis. Urothelial cancer-associated 1 (UCA1) had been reported as the oncogenic long non-coding RNA in many tumors, but the role of UCA1 in EC is still unclear. METHOD: QRT-PCR was used to analysis the level of UCA1 in the proliferative endometrium, primary EC tissue and lymph node metastasis tissue of EC...
June 24, 2016: Cancer Biomarkers: Section A of Disease Markers
Haifeng Xia, Ji Shen, Shaomu Chen, Haitao Huang, Yaozeng Xu, Haitao Ma
BACKGROUND: The prognostic value of vascular endothelial growth factor C (VEGF-C) in patients with esophageal cancer (EC) remains controversial. The aim of this meta-analysis was to clarify the association of VEGF-C with survival in EC patients. METHODS: We performed a meta-analysis that included eligible studies to expound the effect of VEGF-C in EC survival. Eligible studies published until November 2015 was identified using available databases. STATA 12.0 was performed in this meta-analysis...
June 24, 2016: Cancer Biomarkers: Section A of Disease Markers
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