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Cancer Biomarkers: Section A of Disease Markers

Shanshan Wang, Shichang Cui, Wenming Zhao, Zhiling Qian, Hui Liu, Yuhan Chen, Fudong Lv, Hui-Guo Ding
BACKGROUND: Circular RNAs (circRNAs) play an important role in pathogenesis and development of hepatocellular carcinoma (HCC). However, circRNA expression profiles in hepatitis B Virus (HBV)-related HCC remain to be studied. METHODS: Total 13 HBV-related HCC patients were enrolled for study. Three HCC and 3 paired adjacent non-tumorous (NT) tissues from 3 patients were performed for microarray. Ten pairs of HCC tissues were used to verify the identified up-regulated and down-regulated circRNAs obtained from the microarray data by quantitative real-time reverse transcription PCR (qRT-PCR)...
May 29, 2019: Cancer Biomarkers: Section A of Disease Markers
Yu Cai, Pu Yan, Ge Zhang, Wenqi Yang, Haiping Wang, Xiaohu Cheng
OBJECTIVE: Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Recently, long non-coding RNAs (lncRNAs) were found to be critical modulators in the CRC progression. The aim of this study is to investigate the potential roles of lncRNA P73 antisense RNA 1T (TP73-AS1) in CRC development and progression. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to determine relevant gene expression levels; western blot was performed to determine protein expression levels; CCK-8, colony formation, wound healing and Transwell invasion assays were used to determined CRC cell proliferation, migration and invasion; in vivo tumor growth was assessed in xenograft mice model...
June 29, 2018: Cancer Biomarkers: Section A of Disease Markers
Yi Rang Kim, Mi Ran Byun, Jin Woo Choi
BACKGROUND: Hepatitis B virus (HBV) accounts for more than 60% of hepatocellular carcinoma (HCC) cases. However, there is limited information about the features of HBV-driven HCC that differentiate it from other types of HCC. OBJECTIVE: The aim of this study is to find a gene specific to HBV-driven HCC and understand its role during tumorigenesis. METHODS: The differences in gene expression patterns were analyzed among patients with hepatitis virus-unrelated liver cirrhosis, and hepatitis C virus- and HBV-driven HCC...
June 28, 2018: Cancer Biomarkers: Section A of Disease Markers
Xiaohui Wang, Huajun Qu, Yinghe Dong, Guozhi Wang, Yuchen Zhen, Pengsu Yi
Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence of drug resistance remains a challenge. To define molecular mechanisms of vemurafenib resistance, we generated A375-R, WM35-R cell lines resistant to vemurafenib and show that the phosphorylated (p)-STAT3 was upregulated in these cells in vitro and in vivo. In particular, activation of the Signal-transducer-and-activator-of-transcription 3 (STAT3) pathway was associated with vemurafenib resistance...
June 28, 2018: Cancer Biomarkers: Section A of Disease Markers
Lan Pang, Jing Wang, Yong Fan, Rui Xu, Yuping Bai, Liangcai Bai
OBJECTIVE: To investigate the correlations of expression of vascular endothelial growth factor (VEGF) in gastric cancer tissues of patients and magnetic resonance imaging (MRI) features with clinical tumor-node-metastasis (TNM) staging and lymph node metastasis, and to analyze the diagnostic value of MRI features for preoperative TNM staging and lymph node metastasis of patients with gastric cancer, and the roles of VEGF in tumor development and metastasis. METHODS: A total of 120 gastric cancer patients treated in our hospital from May 2015 to July 2017 were selected as objects of study...
June 27, 2018: Cancer Biomarkers: Section A of Disease Markers
Jian Li, Rui Ma, Zhenbin Cao, Dongmei Zhang
OBJECTIVE: To investigate the correlations of magnetic resonance imaging (MRI) manifestations with survivin gene expression in primary hepatocellular carcinoma (HCC). METHODS: A total of 84 HCC patients receiving partial hepatectomy in the Surgery Department and Oncology Department in our hospital from April 2011 to May 2014 were recruited. At 1 week before operation, MRI was used to examine the imaging features of liver, a certain size of area was defined and the signal value of each sequence was recorded...
June 27, 2018: Cancer Biomarkers: Section A of Disease Markers
Xin Li, Wenyi Ma, Xiaojie Wang, Yunzhe Ci, Yina Zhao
BACKGROUND: Annexin A5 (ANXA5) is a kind of Ca2+-dependent phospholipid binding protein which is involved in cell membrane dynamics and organization. Recent data showed that ANXA5 might involve in tumorigenesis. OBJECTIVE: To explore what role ANXA5 play in human uterine cervical carcinoma. MATERIALS AND METHODS: In this study, a recombined ANXA5 plasmid was constructed and uterine cervical carcinoma cell lines HeLa and SiHa were transfected with it...
June 27, 2018: Cancer Biomarkers: Section A of Disease Markers
Jianfen Yuan, Chunhong Xiao, Huijun Lu, Haizhong Yu, Hong Hong, Chunyan Guo, Zhimei Wu
Breast cancer is one common female specific malignant tumor and has gradually increased incidence. Matrix metalloproteinase-9 (MMMP-9) and its inhibitor TIMP-1 participate in tumor invasion and metastasis. This study analyzed the effect of various treatment approaches on TIMP-1 and MMP-9 levels in terminal stage breast cancer. Post-op breast cancer patients including chemo-radio therapy group, radio-chemo therapy group and simultaneously chemo- and radio-therapy group were compared for efficacy, along with assays for TIMP-1 and MMP-9 levels for analyzing their correlation with clinical-pathological features of breast cancer...
June 27, 2018: Cancer Biomarkers: Section A of Disease Markers
Ivana Baranova, Helena Kovarikova, Jan Laco, Ondrej Dvorak, Iva Sedlakova, Vladimir Palicka, Marcela Chmelarova
BACKGROUND: Aberrant DNA methylation of protocadherins (PCDHs) has been associated with development and progression of various types of cancer. It could represent possible direction in the search for critically needed tumor biomarkers for ovarian cancer. OBJECTIVE: To investigate methylation of δ2 group of non-clustered PCDHs in high-grade serous ovarian carcinoma (HGSOC) tissue in comparison with control tissue. METHODS: We used next-generation sequencing for detecting regions with the most altered methylation...
June 25, 2018: Cancer Biomarkers: Section A of Disease Markers
Jin-Zhang Cheng, Jun-Jun Chen, Zong-Gui Wang, Dan Yu
OBJECTIVE: Accumulating studies have revealed that microRNAs (miRs) play a critical role in the development and progression of nasopharyngeal carcinoma (NPC), which is a disease with a remarkable racial and geographical distribution. In our study, through the alteration in the expression of microRNA-185 (miR-185) in NPC cells by microarray-based gene expression profiling, we subsequently evaluated its ability to influence NPC cells and associated mechanism. METHODS: The expressions of miR-185 and HOXC6 in NPC and paracancerous tissues collected from patients with NPC were detected...
June 24, 2018: Cancer Biomarkers: Section A of Disease Markers
Yonghua Mou, Dongguo Wang, Renwei Xing, Hanqiu Nie, Yiping Mou, Yang Zhang, Xianfei Zhou
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancer worldwide and chronic infection of hepatitis B virus (HBV) serve as one of leading causes of HCC. OBJECTIVE: This study aimed to identify the novel long noncoding RNAs (lncRNAs) biomarkers for HBV-associated HCC. METHODS: The lncRNA and mRNA expression profiles of HCC patients with HBV infection were downloaded from The Cancer Genome Atlas. The differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) between HCC and adjacent tissues were identified...
June 23, 2018: Cancer Biomarkers: Section A of Disease Markers
Daoqin Dou, Shaohua Yang, Yunzheng Lin, Jiren Zhang
PURPOSE: The purpose of this study was to establish a risk scoring system based on miRNAs to evaluate the prognosis in pancreatic adenocarcinoma. METHODS: Using a miRNA microarray dataset (179 pancreatic adenocarcinoma specimens and 4 normal control specimens) from TCGA, differentially expressed miRNAs were identified. Cox proportional hazards regression analysis was used to identify significant prognostic miRNAs, with which a risk scoring system was established and tested on a validation set...
June 22, 2018: Cancer Biomarkers: Section A of Disease Markers
Azadeh Andishe-Tadbir
BACKGROUND: Interleukin-33 (IL-33) has been recently discovered as an influential factor in the process of tumor immunity, and is presented in cancer pathogenesis. OBJECTIVE: This study aimed to determine the serum levels of IL-33 in patients with benign and malignant salivary glands tumor (SGT). METHODS: This descriptive cross-sectional study was performed on 47 samples of malignant SGTs including 18 mucoepidermoid carcinoma (MEC), 8 adenoid cystic carcinoma (ADCC), 21 malignant mixed tumor (MMT), and 14 benign pleomorphic adenoma (PA)...
June 22, 2018: Cancer Biomarkers: Section A of Disease Markers
Xiaoyan Ji, Hanting Zhu, Xiaoxiao Dai, Yujun Xi, Yujing Sheng, Ce Gao, Hairui Liu, Yanping Xue, Jiachi Liu, Jia Shi, Yongsheng Zhang, Yanming Chen, Xingliang Dai, Ming Li, Aidong Wang, Jun Dong
OBJECTIVE: Guanylate binding protein-1 (GBP1) is highly associated with cell proliferation, and can modulate growth and invasiveness of gliomas. The relationship between GBP1 expression and the prognosis of glioma patients is further evaluated for the purpose of investigating whether GBP1 can serve as an predictor for evaluating prognosis of glioma patients. METHODS: GBP1 expression in 528 glioblastoma multiforme (GBM) patients of The Cancer Genome Atlas (TCGA) database were investigated, then 103 surgical specimens from glioma patients in our center were further evaluated...
June 22, 2018: Cancer Biomarkers: Section A of Disease Markers
Meng-Hui Zhang, Hu Niu, Zheng Li, Ren-Tao Huo, Jun-Mei Wang, Jun Liu
OBJECTIVE: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy that has a poor prognosis. Through the literatures, TINAG significantly participated in the processes of the renal-associated diseases, but there were no studies about the roles of TINAG in the HCC development. Hence, we attempted to use the HCC samples collected by ourselves to reveal the clinical significance and prognostic impact of TINAG in HCC. METHODS: We first measured the expression level of TINAG in HCC on the basis of TCGA database...
June 21, 2018: Cancer Biomarkers: Section A of Disease Markers
Tao Jia, Run Zhang, Hua-Yuan Zhu, Jin-Hua Liang, Li Wang, Wei Wu, Lei Cao, Jian-Yong Li, Wei Xu
BACKGROUND: Peripheral blood absolute monocyte count (AMC) and lymphocyte to monocyte ratio (LMR) have strong prognostic value in various forms of lymphomas. It was found that higher AMC and lower LMR were associated with poor prognosis in B cell lymphoma. However, their prognostic significance in systemic anaplastic large cell lymphoma (sALCL) remained to be determined. OBJECTIVE: This study was aimed at investigating the prognostic significance of AMC and LMR in sALCL...
June 12, 2018: Cancer Biomarkers: Section A of Disease Markers
Yiqun Huang, Yong Zou, Luhui Lin, Xudong Ma, Hongpu Chen
BACKGROUND: MicroRNA-34a (miR-34a), as a tumor-suppressive miRNA, has been found to induce cell apoptosis in acute myeloid leukemia (AML). However, the diagnostic and prognostic significance of miR-34a in AML remains largely unknown. OBJECTIVE: We aimed to explore its associations with clinical characteristics and prognosis of AML patients. METHODS: This study detected serum miR-34a level in 117 diagnosed AML patients and 60 control subjects by using qRT-PCR, and results were compared to clinical features and patient outcome...
June 12, 2018: Cancer Biomarkers: Section A of Disease Markers
Hua Zhong, Jun Yang, Bin Zhang, Xiaofang Wang, Lihong Pei, Lei Zhang, Zhiqiang Lin, Yanan Wang, Chengbin Wang
Breast cancer is the most common malignancy in women which increases gradually all over the world. LncRNA GACAT3 has been found to be increased in gastric cancer and associated with tumor malignancy. However, whether GACAT3 plays a role in the regulation of breast cancer is not known. In the present study, we found that GACAT3 expression was increased in breast cancer tissues and cells compared with adjacent normal tissues and normal cells. High GACAT3 expression was correlated with the poor prognosis of breast cancer patients...
June 12, 2018: Cancer Biomarkers: Section A of Disease Markers
Bharath Kumar Velmurugan, Wei-Hsiang Chang, Chia-Min Chung, Chung-Min Yeh, Chien-Hsun Lee, Kun-Tu Yeh, Shu-Hui Lin
BACKGROUND: Discoidin domain receptors (DDRs), a collagen receptor tyrosine kinase, play a major role in cancer progression. DDR2 has been suggested as a prognostic marker in several cancer types; however, the correlation between DDR2 expression and clinical outcome of oral cancer patients in Taiwan population has not been investigated. MATERIALS AND METHODS: In the present study we sought to determine the clinical significance of Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) expression in oral squamous cell carcinoma (OSCC) patients...
June 11, 2018: Cancer Biomarkers: Section A of Disease Markers
Zahra Faghih, Safoora Deihimi, Abbas Ghaderi, Nasrollah Erfani
To find out if the T cell repertoire is efficiently and specifically provoked in patients with breast cancer, we have investigated the clonotypes of main T cell subsets (based on Vβ-Chain) in tumor draining lymph nodes. CD4+ helper, CD8+ cytotoxic and (CD4+CD127dimCD25+) regulatory T cells, were negatively selected, and isolated, from lymph node mononuclear cells of 14 untreated patients with breast cancer. Four non-malignant patients, who underwent surgical operation, were also recruited as the control group...
June 11, 2018: Cancer Biomarkers: Section A of Disease Markers
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