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Cancer Biomarkers: Section A of Disease Markers

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https://www.readbyqxmd.com/read/27814278/functional-analysis-of-serum-micrornas-mir-21-and-mir-106a-in-renal-cell-carcinoma
#1
Hamulati Tusong, Naibijiang Maolakuerban, Jin Guan, Mulati Rexiati, Wen-Guang Wang, Baihetiya Azhati, Yiliyaer Nuerrula, Yu-Jie Wang
OBJECTIVE: microRNAs (miRNAs) plays an important role in tumor development and progression and act as oncogenes or tumor suppressor genes in the carcinogenesis process. miRNA is stable in serum, and recent studies have demonstrated the feasibility of using circulating miRNA as biomarkers in cancer patients. However, currently, no serum biomarkers for the early diagnosis and prognosis of renal cell carcinoma (RCC) have been reported. Therefore, a new molecular marker for early diagnosis and evaluation of recurrence after surgery is required...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814277/distinctive-expression-pattern-of-oct4-variants-in-different-types-of-breast-cancer
#2
Saamaaneh Soheili, Malek Hossien Asadi, Alireza Farsinejad
BACKGROUND: OCT4 is a key regulator of self-renewal and pluripotency in embryonic stem cells which can potentially encode three spliced variants designated OCT4A, OCT4B and OCT4B1. Based on cancer stem cell concept, it is suggested that the stemness factors misexpressed in cancer cells and potentially is involved in tumorigenesis. OBJECTIVE: Accordingly, in this study, we investigated the potential expression of OCT4 variants in breast cancer tissues. METHODS: A total of 94 tumoral and peritumoral breast specimens were evaluated with respect to the expression of OCT4 variants using quantitative RT-PCR and immunohistochemical (IHC) analysis...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814276/overexpression-of-receptor-for-advanced-glycation-end-products-rage-in-ovarian-cancer
#3
Farzaneh Rahimi, Jamshid Karimi, Mohammad Taghi Goodarzi, Massoud Saidijam, Iraj Khodadadi, Amir Nader Emami Razavi, Maryam Nankali
BACKGROUND: Ovarian cancer is one of the important challenges in the field of gynecologic oncology because of some problems in understanding its etiology and pathogenesis. Receptor for advanced glycation end products (RAGE) is a multiligand trans-membranous receptor which is upregulated in some human cancers. Mechanisms of RAGE involvement in carcinogenesis of ovarian cancer are unknown. OBJECTIVE: This study aimed to investigate the expression of RAGE in ovarian cancers and its association with clinicopathological characteristics...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814275/detection-of-bladder-cancer-in-urine-sediments-by-a-hypermethylation-panel-of-selected-tumor-suppressor-genes
#4
Michaƚ Pietrusiński, Ƚukasz Képczyński, Adam Jédrzejczyk, Edyta Borkowska, Magdalena Traczyk-Borszyńska, Maria Constantinou, Bogdan Kaƚużewski, Maciej Borowiec
BACKGROUND: Promoter hypermethylation can be a useful biomarker for early detection and prognosis of bladder cancer, monitoring response to treatment and complement classical diagnostic procedures. OBJECTIVE: The molecular test was performed on DNA from bladder cancer cells in voided urine samples, tumor tissue DNA and normal control DNAs. We aimed to assess the diagnostic potential of epigenetic changes in urine DNA from bladder cancer cases at various clinico-pathological stages of the disease...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814274/urinary-ngal-for-the-diagnosis-of-the-renal-injury-from-multiple-myeloma
#5
Wenhan Du, Ting Shen, Hui Li, Yingying Liu, Lagu He, Li Tan, Min Hu
OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) has been proved as a sensitive biomarker in acute and chronic renal injury. Renal impairment is a common complication of multiple myeloma (MM). We attempt to assess the value of NGAL for the early and accurate diagnosis of renal injury in MM patients. METHODOLOGY: Forty-five MM patients with CKD stage I to V(MM-renal group), 20 MM patients with normal kidney function (MM-non-renal group), and 37 healthy volunteers (healthy control) were compared for serum and urinary NGAL and other renal injury biomarkers (Creatinine[CRE]; Cystatin-C [CysC]; N-acetyl-beta-D-glucosaminidase [NAG])...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814273/overexpressions-of-mir-212-are-associated-with-poor-prognosis-of-patients-with-pancreatic-ductal-adenocarcinoma
#6
Zhengrong Wu, Liangjing Zhou, Guoping Ding, Liping Cao
BACKGROUND: The miR-212 was among the top differentially expressed miRNAs in pancreatic ductal adenocarcinoma (PDAC). OBJECTIVE: The aim of this study was to investigate the expression of miR-212 in PDAC and evaluate its correlation with major clinicopathologic features and patients' survival. METHODS: Fluorescence in situ hybridization (FISH) was adopted to examine miRNA expression in 45 pancreatic cancer and 20 normal pancreatic tissues...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814272/plasma-orosomucoid-2-as-a-potential-risk-marker-of-cholangiocarcinoma
#7
Rucksak Rucksaken, Lakhanawan Charoensuk, Porntip Pinlaor, Chawalit Pairojkul, Narong Khuntikeo, Somchai Pinlaor
BACKGROUND: Cholangiocarcinoma (CCA), a malignant tumor of the biliary epithelium, is a tumor with an ineffective diagnosis and poor prognosis. We have previously identified an overexpression of orosomucoid 2 (ORM2) along with CCA development in hamsters using a proteomics technique. OBJECTIVE: To evaluate plasma ORM2 as a candidate risk biomarker for CCA in humans. METHODS: Overexpression of ORM2 in CCA patients was assessed by western blotting and immunohistochemistry...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27814271/the-role-of-red-cell-distribution-width-in-the-prognosis-of-patients-with-gastric-cancer
#8
Pinar Yazici, Uygar Demir, Emre Bozkurt, Gurhan R Isil, Mehmet Mihmanli
BACKGROUND: Although the red cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge the prognostic value of RDW in gastric carcinoma has not been studied, so far. OBJECTIVE: We aimed to investigate the role of red cell distribution width (RDW) in predicting prognosis in gastric cancer patients. METHODS: All gastric cancer patients who underwent curative surgery (n= 172, 110M/62F) over a five-year study period were evaluated...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27791993/lncrna-tug1-promotes-breast-cancer-cell-proliferation-via-inhibiting-mir-9
#9
Xiao-Bo Zhao, Guo-Sheng Ren
BACKGROUND: Several lncRNAs have been found to be dysregulated in breast cancer and closely correlated with its diagnosis and prognosis. However, the role of TUG1 in breast cancer was still poorly understood. METHODS: The expression of TUG1 in breast cancer tissues and cells was detected by RT-qPCR. Cell viability was examined by MTT assay; cell cycle and cell apoptosis were detected by flow cytometry. Dual luciferase reporter assay was performed to detect the relationship between TUG1 and microRNA-9 (miR-9)...
October 28, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802201/serum-microrna-15a-level-acts-as-a-potential-diagnostic-and-prognostic-biomarker-for-human-esophageal-squamous-cell-carcinoma
#10
Jialin Li, Ming Li, Feng Gao, Xiaojun Ge
BACKGROUND: Clinical significance of microRNA (miR)-15a in human esophageal squamous cell carcinoma (ESCC) remains unclear. OBJECTIVE: To evaluate the expression level of miR-15a and to determine its potential for diagnosis and prognosis in ESCC. METHODS: Quantitative reverse transcription polymerase chain reaction was performed to examine the expression levels of miR-15a in ESCC tissues and patients' sera. The diagnostic and prognostic implications of serum miR-15a level in human ESCC were further evaluated...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802200/modern-molecular-biomarkers-of-head-and-neck-cancer-part-i-epigenetic-diagnostics-and-prognostics-systematic-review
#11
Gintaras Juodzbalys, David Kasradze, Marco Cicciù, Aurimas Sudeikis, Laurynas Banys, Pablo Galindo-Moreno, Zygimantas Guobis
INTRODUCTION: Nearly half of the head and neck cancer cases are diagnosed in late stages. Traditional screening modalities have many disadvantages. The aim of the present article was to review the scientific literature about novel head and neck cancer diagnostics - epigenetic biomarkers. EVIDENCE ACQUISITION: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802199/placental-type-alkaline-phosphatase-tissue-expression-in-ovarian-serous-carcinoma
#12
Maria Orsaria, Ambrogio P Londero, Stefania Marzinotto, Carla Di Loreto, Diego Marchesoni, Laura Mariuzzi
OBJECTIVE: To analyze the expression profile of placental type alkaline phosphatase (PLAP), cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) in serous ovarian cancer and to correlate their expression with the tumor aggressiveness and progression. METHODS: Retrospective study considering a tissue microarray of 82 women affected by ovarian serous cancer. Protein expression was assessed by immunohistochemistry on ovarian serous cancer tissue samples...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802198/variable-alterations-of-mitochondrial-microsatellite-instability-and-dna-copy-number-in-pulmonary-hamartomas
#13
Deok Heon Lee, Jae-Ho Lee, Dong Yoon Keum, Dae-Kwang Kim
BACKGROUND: The genetic alteration of mitochondrial DNA has been regarded as an important step in the development of several human tumors. OBJECTIVE: The purpose of this study was to identify frequency of mitochondrial microsatellite instability (mtMSI) and alterations in mitochondrial DNA copy number (mtCN) in pulmonary hamartoma. METHODS: DNA was isolated from tumor tissue and matched non-tumor tissue in 30 patients with pulmonary hamartoma...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802197/screening-for-the-optimal-gene-and-functional-gene-sets-related-to-breast-cancer-using-differential-co-expression-and-differential-expression-analysis
#14
Lei Wang, Hong Ma, Lixia Zhu, Liping Ma, Lanting Cao, Hui Wei, Jumei Xu
OBJECTIVE: To investigate novel gene sets related to breast cancer (BC) using differential co-expression and differential expression (DECODE). METHODS: T statistics was used to quantify the degree of DE of each gene, and then Z was adopted to quantify the correlation difference between expression levels of two genes. Two optimal thresholds for defining substantial change in DE and DC were selected for each gene using chi-square maximization, and the corresponding gene was defined as the optimal gene...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802196/prognostic-factors-for-survival-in-advanced-appendiceal-cancers
#15
Fatima Khan, Rachel I Vogel, Gustave K Diep, Todd M Tuttle, Emil Lou
BACKGROUND: Appendiceal cancer is a rare malignancy. The optimal pathologic classification and prognostic factors for survival and treatment strategies remain poorly understood. OBJECTIVE: The aim of this retrospective cohort study was to determine prognostic factors, including markers of systemic inflammation, for survival in a cohort of patients with advanced appendiceal adenocarcinomas. METHODS: The study included patients with advanced appendiceal carcinoma that were treated between January 2006 and June 2012...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802195/birc7-and-klf4-expression-in-benign-and-malignant-lesions-of-pancreas-and-their-clinicopathological-significance
#16
Zhulin Yang, Daiqiang Li, Ziru Liu, Xiongying Miao, Leping Yang, Qiong Zou, Yuan Yuan
This study investigated the KLF4 and BIRC7 protein expression in malignant and benign pancreatic tissues by immunohistochemical staining and the clinical and pathological significance of KLF4 and BIRC7 expression in PDAC. KLF4 expression was significantly lower, whereas BIRC7 expression was significantly higher in PDAC than that in peritumoral tissue, benign pancreatic lesions, and normal pancreatic tissue (P < 0.01). The percentage of positive BIRC7 and negative KLF4 expression was significantly lower in PDAC patients with well differentiated tumors, maximum tumor size < 3 cm, no lymph node metastasis, no invasion to the surrounding tissues and organs, and TNM stage I/II stage disease than in patients with poorly differentiated tumor, maximum tumor size > 5 cm, lymph node metastasis, invasion to surrounding tissues and organs, and TNM stage III/IV disease (P < 0...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802194/screening-of-exosomal-micrornas-from-colorectal-cancer-cells
#17
Cillian Clancy, Sonja Khan, Claire L Glynn, Emma Holian, Peter Dockery, Pierce Lalor, James A L Brown, Myles R Joyce, Michael J Kerin, Roisin M Dwyer
BACKGROUND: Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown. OBJECTIVE: To identify the full range of exosome encapsulated miRNAs secreted from 2 colorectal cancer cell lines and to investigate engineering of exosomes over-expressing miRNAs. METHODS: Exosomes were isolated from HCT-116 and HT-29 cell lines...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802193/preoperative-multiplication-of-neutrophil-and-monocyte-counts-as-a-prognostic-factor-in-epithelial-ovarian-cancer
#18
E Sun Paik, Minhee Shim, Hyun Jin Choi, Yoo-Young Lee, Tae-Joong Kim, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae
BACKGROUND: Epithelial ovarian cancer (EOC) is leading cause of death in gynecologic cancer, and finding prognostic factors is important for establishing treatment plans. OBJECTIVE: The aim of this study was to investigate the prognostic value of the multiplication of neutrophil and monocyte counts (MNM) in epithelial ovarian cancer (EOC). METHODS: Data were retrospectively collected from Samsung Medical Center for EOC patients treated from January 2002 to December 2012...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802192/mean-platelet-volume-as-a-possible-biomarker-of-tumor-progression-in-the-rectal-cancer
#19
Marcin Wƚodarczyk, Jakub Kasprzyk, Aleksandra Sobolewska-Wƚodarczyk, Jakub Wƚodarczyk, Marcin Tchórzewski, Adam Dziki, Ƚukasz Dziki
BACKGROUND: Rectal cancer is a major cause of death and an early diagnosis is crucial in decreasing mortality. Previous studies found a relation between chronic inflammation and increased risk of rectal cancer. It was shown that mean platelet volume (MPV) level might be a marker of subclinical inflammatory process in gastrointestinal tract. OBJECTIVE: To determinate whether MPV could be a useful biomarker of tumor progression in the rectal cancer. METHODS: One hundred and three patients with rectal cancer who underwent surgical resection of tumor were enrolled in the study...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27802191/molecular-combing-a-new-tool-in-diagnosing-leukemia
#20
Antoine Ittel, Hélène Zattara, Charlène Chaix, Gérard Michel, Nicolas Levy
BACKGROUND: According to the World Health Organization (WHO), recurrent cytogenetic abnormalities define many specific groups of hematopoietic tumors of acute myeloid and lymphoblastic leukemia, and these abnormalities are often strongly associated with prognosis and sometimes require specific treatments. These rearrangements are commonly detected by conventional and molecular cytogenetic techniques. OBJECTIVE: Using an alternative method, we sought to highlight the presence of chromosomal rearrangements...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
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