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Cancer Biomarkers: Section A of Disease Markers

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https://www.readbyqxmd.com/read/30198871/mir-101-inhibits-cell-proliferation-and-invasion-of-pancreatic-cancer-through-targeting-stmn1
#1
Lin Zhu, Yinan Chen, Kai Nie, Yongxin Xiao, Hong Yu
MiRNAs regulated most genes expression, which were proved important in various tumors. In this study, we want to investigate miR-101 effect and molecular mechanism on pancreatic cancer (PC), the research about this was blank now. RT-PCR analysis showed that miR-101 expression was declined in PC. MTT assay found that miR-101 mimic suppressed cell viability, while suppressing miR-101 facilitated cell proliferation. Transwell assay showed that miR-101 mimic inhibited cell invasion, but promoted cell invasion by miR-101 inhibitor...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198870/eif3b-correlates-with-advanced-disease-stages-and-poor-prognosis-and-it-promotes-proliferation-and-inhibits-apoptosis-in-non-small-cell-lung-cancer
#2
Yuan Tian, Ke Zhao, Luer Yuan, Jialing Li, Shuangbing Feng, Yufeng Feng, Zhongqi Fang, Hui Li, Ruoyu Deng
BACKGROUND: Although up-regulation of EIF3B correlates with poor prognosis in carcinomas, the role of EIF3B in non-small cell lung cancer (NSCLC) is rarely known. OBJECTIVE: We aimed to investigate correlation of EIF3B with clinicopathological features and prognosis in NSCLC patients, and clarify its effect on cells proliferation and apoptosis. METHODS: Two hundred and eleven NSCLC patients underwent surgery were retrospectively reviewed. Tumor tissue and paired adjacent tissue were obtained...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198869/key-mirnas-and-target-genes-played-roles-in-the-development-of-clear-cell-renal-cell-carcinoma
#3
Jianmin Liu, Beibei Liu, Yuanyuan Guo, Zhijun Chen, Wei Sun, Wuyue Gao, Hongliang Wu, Yan Wang
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the most aggressive form of renal cell carcinoma (RCC). OBJECTIVE: This study was aimed to identify the differentially expressed miRNAs and target genes in CCRCC. METHODS: The miRNA and mRNA next-generation sequencing data were downloaded from The Cancer Genome Atlas (TCGA) dataset. Differential expression analysis was performed, followed by correlation analysis of miRNA-mRNA. Functional enrichment and survival analysis was also performed...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198868/down-regulation-of-long-non-coding-rna-anril-inhibits-the-proliferation-migration-and-invasion-of-cervical-cancer-cells
#4
Wei-Yi Zhang, Yin-Jiao Liu, Yan He, Ping Chen
OBJECTIVES: Cervical cancer (CC) is a common malignant tumor in the female reproductive system that is characterized by a high metastatic potential. LncRNA ANRIL has been found to be a cancer oncogene in multiple tumors. In our study, we altered the expression of ANRIL in CC cells and evaluated its ability on influencing proliferation, migration and invasion of CC cells and associated mechanism. METHODS: Differentially expressed lncRNAs in CC were identified by microarray and TCGA analyses...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198863/five-serum-based-mirnas-were-identified-as-potential-diagnostic-biomarkers-in-gastric-cardia-adenocarcinoma
#5
Juan Wang, Huo Zhang, Xin Zhou, Tongshan Wang, JinYing Zhang, Wei Zhu, Hong Zhu, Wenfang Cheng
BACKGROUND: Circulating microRNAs (miRNAs) have been implicated as novel biomarkers for various types of cancers. The aim of the study is to identify serum miRNAs with potential in detecting gastric cardia adenocarcinoma (GCA). METHODS: A three-phase study was designed with 102 GCA patients and 84 cancer-free controls. In the screening phase (3 GCA pools vs. 1 normal control (NC) pool), a total of 35 miRNAs were identified using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel...
August 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198867/carbon-nanoparticle-lymph-node-tracer-improves-the-outcomes-of-surgical-treatment-in-papillary-thyroid-cancer
#6
Yang Liu, Lin Li, Jie Yu, Yu-Xia Fan, Xiu-Bo Lu
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy which is generally accompanied by lymph node metastasis. OBJECTIVE: Our study evaluated whether carbon nanoparticle lymph node tracer can improve the outcomes of surgical treatment in papillary thyroid cancer (PTC). METHODS: Ninety-two patients were selected and underwent total thyroidectomy and lymph node resection. Our study placed 45 individuals into the treatment group (carbon nanoparticle group) and 47 cohorts in the control group (no carbon nanoparticle group)...
August 29, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198866/differential-expression-of-long-non-coding-rna-sox2ot-in-gastric-adenocarcinoma
#7
Pourandokht Farhangiyan, Somayeh Jahandoust, Seyed Javad Mowla, Mitra Khalili
BACKGROUND: Gastric cancer (GC) is the third leading cause of cancer-related death in the world. Dysfunction of long noncoding RNAs (lncRNAs) in cancers, especially those with role in pluripotency, are approved by increasing evidence. OBJECTIVE: SOX2 overlapping transcript (SOX2OT) lncRNA, is aberrantly expressed in different cancers; however its role in gastric cancer still is controversial. MATERIALS AND METHODS: In this study, the expression of SOX2OT was evaluated in 33 matched pair tumor and non-tumor gastric samples and AGS and MKN45 gastric and NTERA2 embryonic carcinoma cell lines by real time PCR...
August 29, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198865/recombinant-adenovirus-p53-combined-with-radiotherapy-improves-efficacy-and-safety-in-the-treatment-of-head-and-neck-lymphoma
#8
Yong-Hua Xu, Shuo-Hui Liu, Fu-Rong Han, Yin-Huan Zhang
OBJECTIVE: Lymphoma is considered to be a kind of malignant tumour. Gene therapy and radiotherapy have been reported as treatment methods for head and neck lymphoma. This study aims to evaluate the efficacy and safety for the treatment of head and neck lymphoma by a combination of recombinant adenovirus p53 (rAd-p53) and radiotherapy. METHODS: A total of 156 patients with head and neck lymphoma were selected. All patients received an intratumor injection of rAd-p53 of four different doses, namely, 0, 1 × 1010 VP, 1 × 1011 VP and 1 × 1012 VP, once a week for 8 weeks, and radiotherapy was administered 3 days after the rAd-p53 injection using the same dosage and method...
August 28, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30175973/lncrna-casc2-expression-is-down-regulated-in-papillary-thyroid-cancer-and-promotes-cell-invasion-by-affecting-emt-pathway
#9
Tao Zhou, Meijun Zhong, Shuyong Zhang, Zhi Wang, Rong Xie, Chengfeng Xiong, Yunxia Lv, Wanzhi Chen, Jichun Yu
BACKGROUND: Long non-coding RNAs (lncRNAs) were recently identified as crucial regulators of papillary thyroid cancer (PTC). However, the clinical role and regulatory functions of lncRNA cancer susceptibility candidate 2 (CASC2) in PTC remain unknown. METHODS: LncRNA CASC2 expression was examined in plasma samples from 68 PTC patients and 39 patients with nodular goiter (NG). Cell proliferation, migration and invasion abilities were evaluated using CCK8 assay and transwell migration and invasion assay...
August 24, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198864/preoperative-platelet-distribution-width-predicts-breast-cancer-survival
#10
Yiru Huang, Ming-Ming Cui, Yuan-Xi Huang, Shuang Fu, Xin Zhang, Hongbo Guo, Rui-Tao Wang
BACKGROUND: Breast cancer is one of the most commonly diagnosed cancers, and the fourth leading cause of cancer deaths in females worldwide. Activated platelets play a key role in tumor growth and tumor metastasis. Platelet distribution width (PDW) is a platelet index, and is altered in patients with malignancies. The aim of this study was to explore whether PDW can effectively predict death outcome of breast cancer patients. STUDY DESIGN: The clinical data of 271 breast cancer patients in our hospital between January 2009 and December 2009 were retrospectively analyzed...
August 23, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30198862/clinical-risk-analysis-of-non-visualized-sentinel-lymph-node-in-breast-cancer
#11
Jing Zhang, Jing Pei, Hong Liu
OBJECTIVE: This study aimed to explore the positive rate of non-visualized sentinel lymph nodes (non-vSLN) [1] in breast cancer (BC) patients and the discrepancy of non-vSLN among different molecular subtypes, in order to further evaluate the clinical risk of non-vSLNs. METHODS: A total of 627 patients were retrospectively analyzed. These patients were pathologically confirmed with invasive breast cancer and underwent sentinel lymph node biopsy (SLNB). Various factors were compared using chi-square test...
August 23, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30175972/association-between-her2-germline-mutation-a270s-and-prognosis-in-patients-with-primary-breast-cancer
#12
Pilei Si, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
PURPOSE: To investigate the association between the HER2 germline mutation Ala270Ser (A270S), located in HER2 extracellular domain, and survival in breast cancer patients. METHODS: HER2 germline mutation A270S was identified in 5395 consecutive patients with operable primary breast cancer using direct Sanger sequencing analysis. Survival curves for patients with HER2 A270S mutation were compared using the Kaplan-Meier method with log-rank test. RESULTS: We identified that 31 cases carried HER2 germline mutation A270S in 5395 patients (0...
August 23, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30175971/aberrant-neat1_1-expression-may-be-a-predictive-marker-of-poor-prognosis-in-diffuse-large-b-cell-lymphoma
#13
Xiuju Wang, Lan Deng, Ling Jiang, Kuo-Fu Tseng, Yuan Liu, Xing Zhang, Ruihong Dong, Zhigang Lu
BACKGROUND: Many studies have demonstrated that the long non-coding RNA (lncRNA), NEAT1_1, plays critical roles in various human tumor entities and is related to the survival of patients with malignancies. However, the role of NEAT1_1 in diffuse large B cell lymphoma (DLBCL) remains unclear. The aim of this study was to investigate the role of NEAT1_1 in DLBCL. METHODS: The expression of NEAT1_1 was evaluated in paraffin-embedded tissues from 64 DLBCL patients and 15 lymphnoditis patients using the ISH method...
August 21, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30103303/taurine-glutamic-acid-and-ethylmalonic-acid-as-important-metabolites-for-detecting-human-breast-cancer-based-on-the-targeted-metabolomics
#14
Xinyang Wang, Xinshu Zhao, Jing Chou, Jiaying Yu, Tongshu Yang, Liyan Liu, Fengmin Zhang
BACKGROUND: This study investigated the use of serum amino acids and organic acids profiles as the novel metabolites for screening breast cancer (BC) patients. METHODS: A total of 116 subjects as training set were divided into the following three groups: BC patients (n= 34), benign (BE) patients (n= 38) and controls (n= 44). The amino acids profiles from three groups were measured using liquid chromatography-mass spectrometry and organic acids profiles in three groups were studied by gas chromatography-mass spectrometry...
July 25, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30103304/mir-486-inhibited-osteosarcoma-cells-invasion-and-epithelial-mesenchymal-transition-by-targeting-pim1
#15
Hanyu Liu, Juan Zhang, Cuihong Xing, Shuxin Kui, Na Guo, Yanli Wang
OBJECTIVE: Osteosarcoma is the most common malignant tumor of bone with high recurrent rate. miR-486 was downregulated and acted as a tumor suppressor in plenty of tumors. The purpose of this study was to explore how miR-486 worked in osteosarcoma on cell invasion and EMT. RESULTS: miR-486 was low expressed in osteosarcoma while PIM1 was overexpressed, and it had negative correlation between miR-486 and PIM1. miR-486 upregulation or PIM1 downregulation could inhibit osteosarcoma cell invasion and EMT...
July 24, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/30103302/diagnostic-value-of-serum-pivka-ii-levels-for-bclc-early-hepatocellular-carcinoma-and-correlation-with-hbv-dna
#16
Jiali Wu, Zheyi Xiang, Le Bai, Lagu He, Li Tan, Min Hu, Yaping Ren
BACKGROUND: It is reported that prothrombin induced by vitamin K absence-II (PIVKA-II) has a better performance of diagnosis for HCC, and has also been known to be an independent risk factor for vascular invasion. Few studies study the relationship between PIVKA-II and HBV DNA. OBJECTIVE: To determine the clinical value of serum Prothrombin induced by vitamin K absence-II (PIVKA-II) in early hepatocellular carcinoma (HCC), and to explore its relationship with vascular invasion and HBV DNA...
July 24, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29991124/overexpression-of-gbp1-predicts-poor-prognosis-and-promotes-tumor-growth-in-human-glioblastoma-multiforme
#17
Xiaoyan Ji, Hanting Zhu, Xiaoxiao Dai, Yujun Xi, Yujing Sheng, Ce Gao, Hairui Liu, Yanping Xue, Jiachi Liu, Jia Shi, Yongsheng Zhang, Yanming Chen, Xingliang Dai, Ming Li, Aidong Wang, Jun Dong
OBJECTIVE: Guanylate binding protein-1 (GBP1) is highly associated with cell proliferation, and can modulate growth and invasiveness of gliomas. The relationship between GBP1 expression and the prognosis of glioma patients is further evaluated for the purpose of investigating whether GBP1 can serve as an predictor for evaluating prognosis of glioma patients. METHODS: GBP1 expression in 528 glioblastoma multiforme (GBM) patients of The Cancer Genome Atlas (TCGA) database were investigated, then 103 surgical specimens from glioma patients in our center were further evaluated...
June 22, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29865041/withdrawn-serum-mir-106b-upregulation-predicts-poor-prognosis-in-patients-with-colorectal-cancer
#18
Yanying Zhao, Qing Ren, Kongxi Zhu
Ahead of Print article withdrawn by publisher.
May 19, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29843219/the-clinicopathological-and-prognostic-significances-of-dkk3-expression-in-cancers-a-bioinformatics-analysis
#19
Guan-Yu Chen, Hua-Chuan Zheng
BACKGROUND: Dkk3 protein attenuates the expression of Wnt3a, Wnt5a and LRP6, and their interaction, and interacts with βTrCP to suppress wnt/β-catenin pathway. METHODS: We performed a bioinformatics analysis of Dkk3 mRNA expression through Oncomine, TCGA and Kaplan-Meier databases up to July 10, 2017. RESULTS: Up-regulated Dkk3 expression was higher in gastric, breast, and ovarian cancers than normal tissues (p< 0.05). Bitter's database showed a higher Dkk3 expression in ovarian cytoadenocarcinoma than clear cell adenocarcinoma (p< 0...
May 11, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29286923/platelet-indices-in-laryngeal-cancer
#20
Shuang Fu, Li Liu, Xin Zhang, Zhi-Ping Liu, Rui-Tao Wang
BACKGROUND: Laryngeal cancer is one of the most common malignancies in the head and neck. Activated platelets play a critical role in cancer development and progression. Altered mean platelet volume (MPV) and platelet distribution width (PDW) have been found in various types of cancer. The purpose of the current study was to investigate the association of platelet indices with laryngeal cancer. STUDY DESIGN: The study included 216 patients with laryngeal cancer, 189 subjects with benign laryngeal disease, and 213 control subjects between January 2015 and December 2015...
February 14, 2018: Cancer Biomarkers: Section A of Disease Markers
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