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Cancer Biomarkers: Section A of Disease Markers

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https://www.readbyqxmd.com/read/29125483/the-targeted-regulation-of-gli1-by-mir-361-to-inhibit-epithelia-mesenchymal-transition-and-invasion-of-esophageal-carcinoma-cells
#1
Pingping Lin, Qingsong Pang, Ping Wang, Xiying Lv, Lanfang Liu, Aike Li
Epithelia-mesenchymal transition (EMT) is critical for invasion and metastasis of esophageal carcinoma. Gli1, a transcriptional factor in Hedgehog pathway, is correlated with EMT, invasion and metastasis of tumors. However, its role in esophageal cancer is still unknown. Bioinformatics analysis revealed relationship between microRNA (miR)-361 and 3'-UTR of Gli1 gene. This study thus investigated the role of miR-361 and Gli1 in invasion and metastasis of esophageal cancer. Both tumor and adjacent tissues were collected from 58 esophageal cancer patients to test the expressions of miR-361 and Gli1, the relationship of which was confirmed by dual-luciferase reporter gene assay...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125481/identification-of-serum-mir-124-as-a-biomarker-for-diagnosis-and-prognosis-in-osteosarcoma
#2
Chunlei Cong, Wenbo Wang, Jun Tian, Tianqi Gao, Weizhuo Zheng, Changlin Zhou
BACKGROUND: It has been demonstrated that microRNAs (miRNAs) play an important role in the carcinogenesis of osteosarcoma. OBJECTIVE: The aim of the present study was to determine the diagnostic and prognostic value of serum miR-124 in osteosarcoma. METHODS: The serum miR-124 expression levels in 114 osteosarcoma patients, 40 periostitis patients and 50 normal controls were detected using real-time quantitative polymerase chain reaction (RT-qPCR)...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125480/methods-and-significance-of-the-combined-detection-of-her2-gene-amplification-and-chemosensitivity-in-gastric-cancer
#3
Yang-Kun Wang, Bin-Feng Yang, Tian Yun, Chao-Ya Zhu, Cong-Yang Li, Bo Jiang, Gong-Ping Wang, Su-Nan Wang, Ying-Ying Li, Mei-Ling Zhu
OBJECTIVE: This study aims to investigate the significance of combined detection of HER2 gene amplification and chemosensitivity in gastric cancer. METHODS: Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and fluorescence reverse-transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of HER2 protein, HER2 gene amplification and the mRNA expression of ERCC1, TUBB3 and TYMS genes in 135 cases of gastric carcinoma...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125479/plasma-3-3-5-triiodo-l-thyronine-t3-level-mirrors-changes-in-tumor-markers-in-two-cases-of-metastatic-cancer-of-the-breast-and-pancreas-treated-with-exogenous-l-t3
#4
Alejandro Rodríguez-Molinero, Aleck Hercbergs, Manuel Sarrias, Antonio Yuste
Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvβ3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine)...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125478/utility-of-paraneoplastic-antigens-as-biomarkers-for-surveillance-and-prediction-of-recurrence-in-ovarian-cancer
#5
Madhumita Chatterjee, Laura C Hurley, Nancy K Levin, Matthew Stack, Michael A Tainsky
BACKGROUND: Ovarian cancer is frequently diagnosed at an advanced stage and 70% of patients experience recurrence months to years from initial diagnosis. The expression of paraneoplastic antigens can result in the occurrence of onconeural autoantibodies in ovarian cancer that may be associated with neurological disorders that are clinically manifested in patients before diagnosis of ovarian cancer. These paraneoplastic antigens can serve as excellent biomarkers not only for early detection but also for monitoring ovarian cancer recurrence...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125477/microrna-186-suppresses-lung-cancer-progression-by-targeting-sirt6
#6
Libo Ruan, Jun Chen, Litao Ruan, Tianrui Yang, Ping Wang
MicroRNAs are a class of small non-coding RNA molecules that play crucial roles in the initiation and progression of lung cancer. This study was undertaken to investigate the expression and roles of miR-186 in lung cancer. Ectopic expression experiments demonstrated that miR-186 functions as a tumor suppressor. Bioinformatic predictions, a luciferase reporter assay, and protein expression analysis suggested that miR-186 could inhibit the protein levels of SIRT6, a purported tumor suppressor gene. Collectively, our results indicated that miR-186 could inhibit lung cancer progression through targeting SIRT6 and that miR-186 may be a therapeutic target for lung cancer...
November 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125476/adrenalectomy-was-recommended-for-patients-with-subclinical-cushing-s-syndrome-due-to-adrenal-incidentaloma
#7
Dong Wang, Zhi-Gang Ji, Han-Zhong Li, Yu-Shi Zhang
OBJECTIVE: To assess whether adrenalectomy may improve biochemical and metabolic impairment for patients with subclinical Cushing syndrome (SCS) due to adrenal incidentaloma (AI) compared with conservative management. METHODS: A total of 87 patients with SCS due to AI in Peking Union Medical College Hospital between September 2011 and January 2016 have been treated. Forty-eight patients underwent laparoscopic adrenalectomy (operative group), whereas 39 were managed conservatively (control group)...
October 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29125482/mirna373-induces-cervical-squamous-cell-carcinoma-siha-cell-apoptosis
#8
Zongyu Liu, Limei Fan, He Zhu, Huimei Yu, Fan Yang, Ruiqi Yang, Fei Wu
OBJECTIVE: Cervical squamous cell carcinoma seriously threats to patient's life and health. MiRNAs have role of regulating cell growth, proliferation, and death. MiRNAs can promote or inhibit cell growth and proliferation. This study discussed the role of miRNA373 in regulating cervical squamous cell carcinoma growth, proliferation, and apoptosis. PATIENTS AND METHODS: MiRNA373 and scramble miRNA were synthetized and transfected to cervical squamous cell carcinoma SiHa cells by lipofectamine...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103030/mir-30a-5p-together-with-mir-210-3p-as-a-promising-biomarker-for-non-small-cell-lung-cancer-a-preliminary-study
#9
Weronika Świtlik, Michał Seweryn Karbownik, Michał Suwalski, Józef Kozak, Janusz Szemraj
BACKGROUND: Although an immense effort has been made to develop novel diagnostic methods and treatment strategies for non-small cell lung cancer (NSCLC), the survival rate of this disease has remained virtually unchanged. Small non-coding RNAs called microRNAs (miRNAs) have appeared to be very promising biomarkers of cancer including NSCLC. OBJECTIVE: We investigated the expression level of six miRNAs, and subsequently we evaluated their diagnostic ability and their clinical significance...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103029/tumor-tissue-katanin-p60-expression-correlates-with-lymph-node-metastasis-and-worse-prognosis-in-patients-with-breast-cancer-a-cohort-study
#10
Li Zuo, Jiang-Shan Ying, Feng-Chun Zhang, Ying-Chun Xu
OBJECTIVE: To evaluate the correlation of katanin P60 expression with clinicopathological grade and overall survival (OS) in patients with breast cancer (BC). METHODS: Three hundred and four operative BC patients were retrospectively reviewed in this cohort study. Tumor tissue sample was acquired from each patient during surgery. Immunofluorescent staining was used to assess katanin P60 expression. RESULTS: There were 265 BC patients with katanin P60 negative expression and 75 patients with katanin P60 positive expression...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103027/inhibition-of-mir-155-a-therapeutic-target-for-breast-cancer-prevented-in-cancer-stem-cell-formation
#11
Jiangcheng Zuo, Yalan Yu, Man Zhu, Wei Jing, Mingxia Yu, Hongyan Chai, Chunzi Liang, Jiancheng Tu
BACKGROUND: Breast cancer is a common cancer in women of worldwide. Cancer cells with stem-like properties played important roles in breast cancer, such as relapse, metastasis and treatment resistance. Micro-RNA-155 (miR-155) is a well-known oncogenic miRNA overexpressed in many human cancers. METHODS: The expression levels of miR-155 in 38 pairs of cancer tissues and adjacent normal tissues from breast cancer patients were detected using quantitative real-time PCR...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103024/long-term-survivors-of-pancreatic-adenocarcinoma-show-low-rates-of-genetic-alterations-in-kras-tp53-and-smad4
#12
Michele Masetti, Giorgia Acquaviva, Michela Visani, Giovanni Tallini, Adele Fornelli, Moira Ragazzi, Francesco Vasuri, Daniela Grifoni, Simone Di Giacomo, Sirio Fiorino, Raffaele Lombardi, David Tuminati, Matteo Ravaioli, Carlo Fabbri, Maria Letizia Bacchi-Reggiani, Annalisa Pession, Elio Jovine, Dario de Biase
BACKGROUND: Pancreatic adenocarcinoma (PDAC) is one of the deadliest human malignancies. Although surgery is currently the only effective treatment for PDAC, most patients survive less than 20 months after tumor resection. OBJECTIVE: The primary goal was to investigate alterations in KRAS, TP53, SMAD4 and CDKN2A/p16 in tumors from patients with exceptionally long survival after surgery. METHODS: Tumors from 15 patients with PDAC that survived more than 55 months after surgery ("LS") were analyzed for KRAS, TP53, IDH1, NRAS and BRAF using next-generation sequencing...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103022/increase-in-cip2a-expression-is-associated-with-cisplatin-chemoresistance-in-gastric-cancer
#13
Juanli Ji, Weiguo Zhen, Yuan Si, Wenjing Ma, Lanlan Zheng, Chen Li, Yonghong Zhang, Shanshan Qin, Te Zhang, Pengfei Liu, Xin Zheng, Ying Liu
BACKGROUND: The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein which involves in the progression of several human malignancies. Development of cisplatin (DDP) resistance is the obstacle to an effective control of gastric cancer (GC) clinically. OBJECTIVE: We thus assessed whether CIP2A expression is associated with sensitivity of GC to DDP. METHODS: Real-time quantitative PCR, immunohistochemical analysis, or western blotting was performed to detect CIP2A expression in GC patients' tissues...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103018/single-nucleotide-polymorphism-rs2274084-of-gap-junction-protein-beta-2-gene-among-epstein-barr-virus-associated-tumors
#14
Hua Xiao, Wen Liu, Zhenzhen Zhao, Yan Zhang, Yingying Song, Bing Luo
BACKGROUND: Gap junction protein beta 2 gene (GJB2) encodes one of connexins- Connexin 26 (Cx26), which mainly expressed in epithelial cells. Cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation. OBJECTIVE: We investigated GJB2 rs2274084 polymorphism in three types of tumors, including nasophoryngeal carcinoma (NPC), gastric cancer (GC) and lymphoma. METHODS: Proteinase K digestion and phenolchloroform purification and QIAamp DNA FFPE tissue kit was used for DNA extraction...
October 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103028/pd98059-impairs-the-cisplatin-resistance-of-ovarian-cancer-cells-by-suppressing-erk-pathway-and-epithelial-mesenchymal-transition-process
#15
Li Hou, Xiaofei Hou, Lijing Wang, Zenghui Li, Beibei Xin, Jing Chen, Xiaofei Gao, Haixia Mu
BACKGROUND: The study was aimed at investigating the role of PD98059 on impairing the cisplatin-resistance of ovarian cancer cells and figuring out the potential mechanism. MATERIAL AND METHODS: Treated with low dose of cisplatin (DDP), DDP-resistant ovarian cancer cells were built and named as SKOV-3/DDP. The cell viabilities of ovarian cancer cell line SKOV-3 and SKOV-3/DDP were detected using MTT assay. Wound healing assay and flow cytometry were performed to detect the migratory ability and cell cycle variation of the two cells and assess the sensibility to DDP in the two cell lines...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29103026/effect-of-minocycline-on-vascular-proliferation-after-corneal-alkaline-burn-a-mechanism-study
#16
Haijun Wu, Xin Dai, Hui Li, Chunying Lv
Impairment of vision or blindness always occurs in the progress of corneal neovascularization (CNV). CNV may cause corneal graft rejection at corneal transplant status. Thus, intervention of CNV is of concern to clinical treatment. Given minocycline was reported with inhibiting effect on CNV, our study was focused on specific effect of minocycline on CNV after corneal alkaline burn. Seventy-five male Sprague Dawley rats were randomly assigned into three groups with an equal number (25). Sodium hydroxide (NaOH) solution was used to establish corneal alkaline burn model...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29081410/whole-exome-sequencing-to-identify-novel-mutations-of-nevoid-basal-cell-carcinoma-syndrome-in-a-chinese-population
#17
Nanhang Lu, Jinzeng Wang, Bijun Zhu, Miaomiao Zhang, Fazhi Qi, Xiangdong Wang, Jianying Gu
BACKGROUND: Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease with a complex genetic etiology. Although three causative genes (PTCH1, PTCH2, SUFU) have been identified through linkage analysis and Sanger sequencing, the genetic background of NBCCS hasn't been fully understood. METHODS: We performed a whole-exome sequencing (WES) in a Han Chinese NBCCS family and two unaffected volunteers to search for its causative gene. Bioinformatic analysis was used to select candidate genes and analyze the functional networks of each candidate gene...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29081409/enhanced-expression-of-the-long-non-coding-rna-snhg16-contributes-to-gastric-cancer-progression-and-metastasis
#18
Dongbo Lian, Buhe Amin, Dexiao Du, Wei Yan
This paper aimed to probe into the expression of long non-coding RNA (lncRNA) SNHG16 in human gastric cancer (GC) and its potential tumor biological functions. The expression of lncRNA SNHG16 was detected in GC and adjacent tissues and GC cell lines using qRT-PCR. GC MGC-803 cells were transfected with siRNA of lncRNA SNHG16, as well as blank and negative control. A series of experiments including CCK-8, flow cytometry, transwell, and wound healing assay were adopted to evaluate the effects of lncRNA SNHG16 on cell growth and metastasis...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29081407/downregulation-of-snhg1-suppresses-cell-proliferation-and-invasion-by-regulating-notch-signaling-pathway-in-esophageal-squamous-cell-cancer
#19
Yijun Zhang, Xintian Jin, Zhe Wang, Xiaokai Zhang, Shen Liu, Gang Liu
BACKGROUND: Long non-coding RNAs (lncRNAs) exert important functions involved in tumorigenesis and cancer progression including esophageal squamous cell cancer (ESCC), however, the clinical role and underlying biological function of Small Nucleolar RNA Host Gene 1 (SNHG1) in ESCC is not well known. METHODS: Quantitative Real-time polymerase chain reaction (QRT-PCR) was used to detect the SNHG1 expression levels in ESCC tissues and adjacent non-cancerous tissues...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29081406/upregulation-of-long-noncoding-rna-pvt1-predicts-unfavorable-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#20
Xu Bao, Junyao Duan, Yongji Yan, Xin Ma, Yu Zhang, Hanfeng Wang, Dong Ni, Shengpan Wu, Cheng Peng, Yang Fan, Yu Gao, Xintao Li, Jianwen Chen, Qingshan Du, Fan Zhang, Xu Zhang
BACKGROUND: Renal cell carcinoma (RCC) is one of the most malignant genitourinary diseases worldwide. Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs in the human genome that are involved in RCC initiation and progression. OBJECTIVE: To investigate the expression of PVT1 in ccRCC and evaluate its correlation with clinicopathologic characteristics and patients' survival. METHODS: Quantitative real-time PCR was performed to examine PVT1 expression in 129 ccRCC tissue samples and matched adjacent normal tissue samples...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
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