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Cancer Biomarkers: Section A of Disease Markers

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https://www.readbyqxmd.com/read/28436387/predictive-value-of-microrna-143-in-evaluating-the-prognosis-of-patients-with-hepatocellular-carcinoma
#1
Jian Zhang, Hai Lin, Xiao-Ying Wang, Dong-Qin Zhang, Jian-Xia Chen, Yan Zhuang, Xiao-Li Zheng
OBJECTIVE: The study aims to evaluate the predictive value of microRNA-143 (miR-143) for the prognosis of patients with hepatocellular carcinoma (HCC). METHODS: Between October 2010 and October 2012, 131 HCC patients were selected as a case group; meanwhile, 122 healthy controls were enrolled as a control group. The miR-143 expression in serum was detected by quantitative real-time polymerase chain reaction (qRT-PCR). These HCC patients were divided into the high miR-143 expression group and the low miR-143 expression group based on the threshold of receiver operating characteristic (ROC) curve...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28387662/clinical-significance-of-serum-dynamics-of-hsp90a-level-esophageal-squamous-cell-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#2
Hongjiang Yan, Baosheng Li, Tingyong Fan, Shumei Jiang, Renben Wang, Mingping Sun
PURPOSE: We evaluate whether the change of heat shock protein 90a (HSP90a) level before and after definitive chemoradiotherapy (CRT) in esophageal squamous cell carcinoma (ESCC) affects tumor response and overall survival (OS). This study aimed to investigate the role of HSP90a reduction ratio after CRT. METHODS: Correlations between pre-CRT HSP90a levels and the tumor response to CRT were analysed. Patients were divided into three groups (Group 1: Serum HSP90a levels pretreatment CRT less than 124 ng/mL; Group 2: pre-CRT HSP90a of 124 ng/mL or more with HSP90a reduction ratio of 65% or more; Group 3: pre-CRT HSP90a of 124 ng/mL or more with HSP90a reduction ratio less than 65%), and their oncologic outcomes were compared...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28387661/effectiveness-and-safety-of-laparoscopic-enucleation-combined-with-selective-arterial-embolization-for-renal-angiomyolipoma
#3
Dong Wang, Han-Zhong Li, Zhi-Gang Ji
OBJECTIVE: This study aims to investigate the clinical value of laparoscopic enucleation combined with selective arterial embolization for the treatment of renal angiomyolipoma. METHODS: Data of patients who underwent laparoscopic nephron-sparing surgery for renal angiomyolipoma between July 2013 and November 2014 in our center were analyzed. RESULTS: Before surgery, 19 patients underwent selective arterial embolization, while 24 patients did not receive this treatment...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28387660/pattern-of-lrp6-gene-expression-in-tumoral-tissues-of-colorectal-cancer
#4
Elham Rismani, Mohammad Sadegh Fazeli, Habibollah Mahmoodzadeh, Aghdas Movassgh, Sina Azami, Morteza Karimipoor, Ladan Teimoori-Toolabi
BACKGROUND: Colorectal cancer (CRC) is known as one of the most leading causes of death from cancer in the world. Wnt signaling pathway is the most important signaling pathway activated in this type of cancer. The low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) functions as a co-receptor in order to trigger this signaling pathway. OBJECTIVE: The expression of LRP6 was studied in cell lines, tumoral and normal adjacent tissues from patients affected with colorectal cancer...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28387659/salivary-and-serum-hpv-antibody-levels-before-and-after-definitive-treatment-in-patients-with-oropharyngeal-squamous-cell-carcinoma
#5
Glenn J Hanna, Vishwajith Sridharan, Danielle N Margalit, Stephanie K La Follette, Nicole G Chau, Guilherme Rabinowits, Jochen H Lorch, Robert I Haddad, Roy B Tishler, Karen S Anderson, Jonathan D Schoenfeld
BACKGROUND: HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence. Laboratory assays that identify virally-mediated disease and predict HPV clearance in OPSCC may have important prognostic implications. OBJECTIVE: Here we investigated serum, salivary HPV16 early (E) antibodies before and after definitive chemoradiotherapy (CRT) in patients with locoregionally advanced OPSCC. METHODS: We prospectively measured salivary, serum samples at the beginning of and 6-7 weeks following the completion of CRT in 44 patients...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28282802/in-situ-memory-t-cells-and-patterns-of-invasion-predict-outcome-in-patients-with-early-stage-oral-squamous-cell-carcinoma
#6
Shan Wang, Jiankai Xu, Yan Meng, Dongxia Qiang, Changsheng Sun, Lei Shi, Eryang Zhao
PURPOSE: The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC). METHODS: One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28282801/thyroid-cancer-with-concurrent-breast-tubular-cancer-a-case-report-and-literature-review
#7
Ying-Jie Xu, Chen Qian, Jun He, Da-Qing Cheng, Liu-Xia Jiang
Here one concurrent case of a patient with both thyroid and breast cancers was discussed here with a comprehensive literature review. On March 21, 2016, a 42-year-old female patient was admitted into our hospital because of right neck mass and left breast mass for 1 week during a routine health examination. On March 22, the combined procedures of complete resection of right thyroid gland plus isthmus with dissection of lymph nodes in right VI region plus left breast regional lumpectomy were performed under endotracheal anesthesia...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28282800/fbln-4-and-bcrp-genes-as-two-prognostic-markers-are-downregulated-in-breast-cancer-tissue
#8
Jamshid Motalebzadeh, Frouzandeh Mahjoubi, Nahid Nafissi, Maria Hashemian, Mohsen Taheri, Younes Hosseinpour
BACKGROUND: Fibulin-4 (FBLN-4) is an extracellular glycoprotein that is upregulated in some cancer and is khown as prognostic marker in ovarian and cervical cancer. Breast cancer resistance protein (BCRP) is an ATP-binding cassette transporter that facilitates the efflux of various anticancer drugs from the cell and cause MDR phenotype in breast tumors. Many studies are available that indicat overexpression of BCRP gene in breast cancer. OBJECTIVE: In the present study we aimed to analyze the expression level of FBLN-4 and BCRP in Iranian breast cancer patients...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28282799/celecoxib-erlotinib-combination-treatment-enhances-radiosensitivity-in-a549-human-lung-cancer-cell
#9
Jian Sun, Ning-Bo Liu, Hong-Qing Zhuang, Lun-Jun Zhao, Zhi-Yong Yuan, Ping Wang
BACKGROUND: Radiosensitivity by blocking the epidermal growth factor receptor and cyclooxygenase-2 pathways with erlotinib and celecoxib in A549 human lung cancer cell was investigated. METHODS: MTT assays were used to detect the antitumor effects of erlotinib and celecoxib in A549 cells. Colony formation assays were used to evaluate the antitumor effects. Flow cytometry analysis was used to assess the cell cycle and cell apoptosis, and western blotting analysis was performed to evaluate the expression of AKT and phosphorylated AKT...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28282798/increased-stathmin-correlates-with-advanced-stage-and-poor-survival-of-non-small-cell-lung-cancer
#10
Biaoxue Rong, Yandong Nan, Hua Liu, Wenlong Gao
BACKGROUND: Previous studies show that overexpression of stathmin involved in the malignant biological behavior of lung cancer. This investigation is to disclose the expression status of stathmin in non-small cell lung cancer (NSCLC) and its clinical value for the diagnosis and prognosis to lung cancer. METHODS: The expression of stathmin in cells and tissues of NSCLC was examined using immunohistochemistry (IHC), in-situ hybridization (ISH), and Western blot. The correlation between stathmin expression and survival of lung cancer patients was evaluated by a Kaplan-Meier method and the multiple regression analysis...
March 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269758/microrna31-ndrg3-regulation-axes-are-essential-for-hepatocellular-carcinoma-survival-and-drug-resistance
#11
Zhonghai Du, Shuxian Niu, Xiaoyu Xu, Qinghui Xu
BACKGROUNDS: Hepatocellular carcinoma (HCC) is an epithelial cancer that originates from hepatocytes and it is the most common primary malignant tumor of the liver. Till now the prognosis of HCC patients is generally poor. The molecular mechanism giving rise to HCC development and recurrence is still largely unknown. MicroRNA-31 (miR-31) is among the most commonly altered microRNAs in human cancers, and alternations of miR-31 expression were reported to play pivotal roles in tumorigenesis and tumor progression...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269757/correlations-of-the-expressions-of-c-jun-and-egr-1-proteins-with-clinicopathological-features-and-prognosis-of-patients-with-nasopharyngeal-carcinoma
#12
Jia-Teng Zhong, Hai-Jun Wang, Jian Yu, Jing-Hang Zhang, Shi-Feng Wang, Xue Yang, Wei Su
This study intended to explore the correlation of the expressions of c-Jun and Egr-1 proteins with clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2008 to January 2011, 123 NPC patients and 59 patients with chronic rhinitis were enrolled in this study. Fresh NPC and normal nasopharynx tissue specimens were obtained during surgery. Immunohistochemistry (IHC) was adopted to determine the positive expressions of the c-Jun and Egr-1 proteins. A 5-year clinical follow-up was conducted on all NPC patients...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269756/preoperative-plasma-fibrinogen-but-not-d-dimer-might-represent-a-prognostic-factor-in-non-metastatic-colorectal-cancer-a-prospective-cohort-study
#13
Tingting Hong, Di Shen, Xiaoping Chen, Xiaohong Wu, Dong Hua
BACKGROUNDS: Cancer progression has been associated with host hemostasis system. Whether preoperative plasma hemostasis factors can predict survival in colorectal cancer is quite intriguing. METHODS: We conducted a prospective cohort study to validate the prognostic significance of three hemostasis parameters - fibrinogen, fibrin degradation products (FDPs) and D-dimer - in non-metastatic colorectal cancer patients treated with curative resection. RESULTS: All three parameters were positively correlated with C reactive protein (CRP) levels and Glasgow Prognostic scores (GPS)...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269755/microrna-124-3p-affects-proliferation-migration-and-apoptosis-of-bladder-cancer-cells-through-targeting-aurka
#14
Qiuyue Yuan, Tingge Sun, Feng Ye, Weisheng Kong, Haofan Jin
OBJECTIVE: The aim of this study was to establish the relationship between miR-124-3p and Aurora A kinase (AURKA) in bladder cancer (BC). METHODS: The expressions of miR-124-3p and AURKA in BC tissues and cell lines were detected using RT-PCR and western blot. BC cells were transfected with miR-124-3p mimics and AURKA siRNA. After this cell proliferation, migration, cell cycle and apoptosis were measured using CCK-8, colony formation assay, wound healing assay and cytometry tests...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269754/evaluation-of-pik3ca-mutations-as-a-biomarker-in-chinese-breast-carcinomas-from-western-china
#15
Jingliang Cheng, Shangyi Fu, Chunli Wei, Mousumi Tania, Asaduzzaman Khan, Saber Imani, Baixu Zhou, Hanchun Chen, Xiuli Xiao, Jingbo Wu, Junjiang Fu
BACKGROUND: PIK3CA gene encodes the p110 α catalytic subunit of the oncoprotein phosphatidylinositol 3-kinase (PI3 K) which regulates many biological processes such as cell proliferation, differentiation, migration and survival through the activation of various signaling pathways. OBJECTIVE: In this study, we have investigated the possible somatic mutations in PIK3CA gene in invasive ductal breast carcinomas of Chinese women from Western China. METHODS: Genomic DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) tissue samples...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269753/lncrna-neat1-is-a-prognosis-biomarker-and-regulates-cancer-progression-via-epithelial-mesenchymal-transition-in-clear-cell-renal-cell-carcinoma
#16
Li Ning, Zhiguo Li, Dianjun Wei, Haiyan Chen, Chao Yang
BACKGROUND: The long non-coding RNAs (lncRNAs) are emerging as important regulators in cancer progression. Clear cell renal cell carcinoma (ccRCC) is one of the most common urological cancers with poor prognosis. In this study, we examined the functional role of the lncRNA, nuclear enriched abundant transcript 1 (NEAT1) in ccRCC progression. METHODS: We performed quantitative real time PCR and western blotting assays to measure mRNA and protein expression levels, respectively...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269752/a-80-gene-set-potentially-predicts-the-relapse-in-laryngeal-carcinoma-optimized-by-support-vector-machine
#17
Bo Yang, Qing Guo, Fei Wang, Kemin Cai, Xueli Bao, Jiusheng Chu
OBJECTIVE: The present study was performed to identify a gene set for predicting the relapse in laryngeal carcinoma using large data analysis methods. METHODS: Two gene expression profile data of laryngeal carcinoma (GSE27020 and GSE25727) were downloaded from public database. Genes associated with tumor relapse, namely informative genes, were identified by Cox regression analysis. Then the protein-protein interaction (PPI) network consisting of informative genes was constructed...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269751/synergistic-efficacy-of-cullin1-and-mmp-2-expressions-in-diagnosis-and-prognosis-of-colorectal-cancer
#18
Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, Zhangjun Qian, Ping Xu, Zhihong Cao, Yan Zhou
BACKGROUND: Cullin1 and MMP-2 have been identified as important markers in various cancers, but their roles in colorectal cancer (CRC) have remained to be discovered. The aim of this study was to investigate the expression pattern and significance of Cullin1 and MMP-2 in CRC. METHODS: A total of 470 CRC patients were enrolled. Archival paraffin-embedded CRC tissue samples were used to generate tissue microarray blocks, which were immunohistochemically stained for Cullin1 and MMP-2...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269750/micrornas-in-esophageal-squamous-cell-carcinoma-potential-biomarkers-and-therapeutic-targets
#19
Li-Li Mei, Yun-Tan Qiu, Bing Zhang, Zhi-Zhou Shi
Esophageal cancer is a common cause of cancer-related deaths worldwide. Squamous cell carcinoma (SCC) is the major histological type of esophageal cancer in developing countries including China, and the prognosis is very poor. Many microRNAs are involved in several important biological and pathologic processes, and promote tumorigenesis. To better understand the prognostic and therapeutic roles of microRNAs in ESCC, we reviewed the diagnosis and prognosis associated oncogenic microRNAs (e.g. miR-21 and miR-17-92 cluster) and tumor suppressor microRNAs (e...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28269749/aurora-a-regulates-autophagy-through-the-akt-pathway-in-human-prostate-cancer
#20
Shiying Zhang, Jianye Li, Gaobiao Zhou, Dawei Mu, Jingmin Yan, Jizhang Xing, Zhiyong Yao, Haibo Sheng, Di Li, Chao Lv, Bin Sun, Quan Hong, Heqing Guo
BACKGROUND: Aurora A kinase is frequently overexpressed in a variety of tumor types, including the prostate. However, the function of Aurora A in autophagy in prostate cancer has not been investigated. Here, we aimed to study the functioning mechanism and autophagy associated signaling pathways of Aurora A in prostate cancer. METHODS: To investigate the biological function of Aurora A, down-regulation of Aurora A was performed followed by functional testing assays...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
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