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Stem Cell Reviews

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https://www.readbyqxmd.com/read/30191384/islet-like-structures-generated-in-vitro-from-adult-human-liver-stem-cells-revert-hyperglycemia-in-diabetic-scid-mice
#1
Victor Navarro-Tableros, Chiara Gai, Yonathan Gomez, Sara Giunti, Chiara Pasquino, Maria Chiara Deregibus, Marta Tapparo, Adriana Pitino, Ciro Tetta, Maria Felice Brizzi, Camillo Ricordi, Giovanni Camussi
A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and pancreas, we studied the potential of adult human liver stem-like cells (HLSC) to generate in vitro insulin-producing 3D spheroid structures (HLSC-ILS). HLSC-ILS were generated by a one-step protocol based on charge dependent aggregation of HLSC induced by protamine. 3D aggregation promoted the spontaneous differentiation into cells expressing insulin and several key markers of pancreatic β cells...
September 6, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30178289/aerosolised-mesenchymal-stem-cells-expressing-angiopoietin-1-enhances-airway-repair
#2
N S S Halim, E S Ch'ng, E Kardia, S A Ali, R Radzi, B H Yahaya
BACKGROUND: The aim of this study was to investigate the effects of MSCs and MSC-expressing ANGPT1 (MSC-pANGPT1) treatment via aerosolisation in alleviating the asthma-related airway inflammation in the rabbit model. METHODS: Rabbits were sensitised and challenged with both intraperitoneal injection and inhalation of ovalbumin (Ova). MSCs and MSC-pANGPT1 cells were aerosolised into rabbit lungs using the MicroSprayer® Aerosolizer Model IA-1B 48 h after injury...
September 3, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30136142/the-impact-of-morphine-on-the-characteristics-and-function-properties-of-human-mesenchymal-stem-cells
#3
Vladimir Holan, Kristina Cechova, Alena Zajicova, Jan Kossl, Barbora Hermankova, Pavla Bohacova, Michaela Hajkova, Magdalena Krulova, Petr Svoboda, Eliska Javorkova
Morphine is an analgesic drug therapeutically administered to relieve pain. However, this drug has numerous side effects, which include impaired healing and regeneration after injuries or tissue damages. It suggests negative effects of morphine on stem cells which are responsible for tissue regeneration. Therefore, we studied the impact of morphine on the properties and functional characteristics of human bone marrow-derived mesenchymal stem cells (MSCs). The presence of μ-, δ- and κ-opioid receptors (OR) in untreated MSCs, and the enhanced expression of OR in MSCs pretreated with proinflammatory cytokines, was demonstrated using immunoblotting and by flow cytometry...
August 22, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30076557/expression-of-cancer-stem-cell-biomarkers-in-human-head-and-neck-carcinomas-a-systematic-review
#4
REVIEW
Raissa Borges Curtarelli, Jussara Maria Gonçalves, Luciane Geanini Pena Dos Santos, Maria Gorete Savi, Jacques Eduardo Nör, Luis André Mendonça Mezzomo, Mabel Mariela Rodríguez Cordeiro
Malignant neoplasms may be composed of several cell groups, including cancer stem cells (CSC). These cells have been related with the capacity of metastasis, relapse and resistance to multiple drugs during chemotherapy. This study aims to identify CSC biomarkers and their expression pattern in human head and neck carcinomas. This study was conducted following the PRISMA checklist. The search for articles was carried out in five databases (PubMed, Scopus, Web of Science, Lilacs and Scielo). The articles found were selected in two phases: 1) reading the titles and / or abstract and 2) reading the full text...
August 3, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30046991/circrna-expression-profiles-in-human-bone-marrow-stem-cells-undergoing-osteoblast-differentiation
#5
Mengjun Zhang, Lingfei Jia, Yunfei Zheng
Circular RNAs (circRNAs), which are produced by back-splicing events in genes, have emerged as factors in gene regulation and normal cellular homeostasis. They play an important role not only in normal development of tissues and organs, but also in disease pathogenesis and cell differentiation. However, the role of circRNAs in bone marrow stem cells (BMSCs) undergoing osteoblast differentiation remains largely unknown. We performed microarray analysis to determine the expression profiles of circRNAs during osteoblast differentiation...
July 25, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29980981/analysis-of-the-paternally-imprinted-dlk1-meg3-and-igf2-h19-tandem-gene-loci-in-nt2-embryonal-carcinoma-cells-identifies-dlk1-as-a-potential-therapeutic-target
#6
Zachariah Payne Sellers, Gabriela Schneider, Magdalena Maj, Mariusz Z Ratajczak
The paternally-imprinted genes insulin-like growth factor 2 (IGF2), H19, delta-like homologue 1 (DLK1), and maternally-expressed gene 3 (MEG3) are expressed from the tandem gene loci IGF2-H19 and DLK1-MEG3, which play crucial roles in initiating embryogenesis and development. The erasure of imprinting (EOI) at differentially methylated regions (DMRs) which regulate the expression of these genes maintains the developmental quiescence of primordial germ cells (PGCs) migrating through the embryo proper during embryogenesis and prevents them from forming teratomas...
July 6, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29938352/znf521-has-an-inhibitory-effect-on-the-adipogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#7
Emanuela Chiarella, Annamaria Aloisio, Bruna Codispoti, Giovanna Nappo, Stefania Scicchitano, Valeria Lucchino, Ylenia Montalcini, Augusto Camarotti, Olimpio Galasso, Manfredi Greco, Giorgio Gasparini, Maria Mesuraca, Heather Mandy Bond, Giovanni Morrone
Mesenchymal stem cells (MSCs) are multipotent progenitors present in the bone marrow stroma and in subcutaneous abdominal fat, an abundant and easily accessible source of MSCs with the ability to differentiate along multiple lineage pathways. The stem cell-associated transcription co-factor Zinc Finger Protein 521 (ZNF521/zfp521) has been implicated in the control of the homeostasis of hematopoietic, neural and osteo-adipogenic progenitors. Here we document through the analysis of a panel of human adipose-derived stem cells (hADSCs), that ZNF521 strongly inhibits the generation of mature adipocytes...
June 25, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29931411/cd34-hematopoietic-stem-cell-count-is-predictive-of-vascular-event-occurrence-in-children-with-sickle-cell-disease
#8
Manoelle Kossorotoff, Mariane De Montalembert, Valentine Brousse, Dominique Lasne, Emmanuel Curis, David M Smadja, Romaric Lacroix, Sebastien Bertil, Elodie Masson, Isabelle Desguerre, Damien Bonnet, Pascale Gaussem
BACKGROUND/OBJECTIVES: Sickle cell disease (SCD) complications mostly result from vascular dysfunction, concerning systemic microvasculature and cerebral large vessels. The aim of this cohort study was to identify potential circulating biomarkers predictive for further vascular event occurrence in pediatric SCD. METHODS: We consecutively enrolled 108 children with SCD at steady state, aged 3-18 years old (median 9.8 years). Hematology, coagulation, hemolysis, endothelial, platelet and vascular activation parameters were recorded at inclusion...
June 21, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30088212/circulating-stem-cells-in-physiology-and-pathology-recent-studies-published-in-stem-cell-reviews-and-reports
#9
EDITORIAL
Mariusz Z Ratajczak
No abstract text is available yet for this article.
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30022351/elevated-numbers-of-circulating-very-small-embryonic-like-stem-cells-vsels-and-intermediate-cd14-cd16-monocytes-in-iga-nephropathy
#10
REVIEW
Andrzej Eljaszewicz, Katarzyna Kleina, Kamil Grubczak, Urszula Radzikowska, Paula Zembko, Paulina Kaczmarczyk, Marlena Tynecka, Karolina Dworzanczyk, Beata Naumnik, Marcin Moniuszko
IgA nephropathy (IgAN) is recognized as most frequent form of primary glomerulonephritis worldwide. IgAN is associated with renal degradation occurring due to irreversible pathological changes leading to glomerulosclerosis and interstitial fibrosis. It remains poorly understood whether and to what extent these changes are followed by the activation of regenerative mechanisms. Therefore, in this study we aimed to evaluate regenerative potential of IgAN patients by quantitating the frequencies of several stem cell types, namely circulating very small embryonic-like stem cells (VSELs), hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs) as well as different monocyte subsets with varying maturation and angiopoietic potential...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29974327/will-ips-cells-regenerate-or-just-provide-trophic-support-to-the-diseased-tissues
#11
LETTER
Deepa Bhartiya
No abstract text is available yet for this article.
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29948753/incognito-are-microchimeric-fetal-stem-cells-that-cross-placental-barrier-real-emissaries-of-peace
#12
REVIEW
Cosmin Andrei Cismaru, Laura Pop, Ioana Berindan-Neagoe
Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested that feto-maternal microchimerism could exert a beneficial effect on the treatment of hematological and solid tumors in patients treated by PBSCT. In this review we report the mechanism of transplacental fetal stem cell trafficking during pregnancy and the effect of their long-term persistence on autoimmunity, GVHD, PBSCT, cancer and stem cell treatment...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29948752/cathelicidin-related-antimicrobial-peptide-cramp-enhances-bone-marrow-cell-retention-and-attenuates-cardiac-dysfunction-in-a-mouse-model-of-myocardial-infarction
#13
Yuri M Klyachkin, Amr Idris, Christopher B Rodell, Himi Tripathi, Shaojing Ye, Prabha Nagareddy, Ahmed Asfour, Erhe Gao, Rahul Annabathula, Mariusz Ratajczak, Jason A Burdick, Ahmed Abdel-Latif
BACKGROUND: Acute myocardial infarction (MI) and the ensuing ischemic heart disease are approaching epidemic state. Unfortunately, no definitive therapies are available and human regenerative therapies have conflicting results. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Cathelicidin related antimicrobial peptides (CRAMPs) enhance chemotactic responsiveness of BMSPCs to low SDF-1 gradients, suggesting a potential role in BMSPCs engraftment...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29860617/stem-cell-sources-and-graft-material-for-vascular-tissue-engineering
#14
REVIEW
Dorothee Hielscher, Constanze Kaebisch, Benedikt Julius Valentin Braun, Kevin Gray, Edda Tobiasch
No abstract text is available yet for this article.
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29804171/dental-pulp-tissue-engineering-using-mesenchymal-stem-cells-a-review-with-a-protocol
#15
REVIEW
Tomoatsu Kaneko, Bin Gu, Phyo Pyai Sone, Su Yee Myo Zaw, Hiroki Murano, Zar Chi Thein Zaw, Takashi Okiji
Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from human and animal sources such as rats. Recently, an in vivo protocol for pulp tissue engineering using implantation of bone marrow MSCs into rat pulpotomized molars was established by our research group. This coronal pulp regeneration model showed almost complete regeneration/healing with dentin bridge formation when the cavity was sealed with mineral trioxide aggregate (MTA) to create a biocompatible seal of the pulp. This method is a powerful tool for elucidating the processes of dental pulp tissue regeneration following implantation of MSCs...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29799101/mesenchymal-stem-cells-miraculous-healers-or-dormant-killers
#16
Abbas Ghaderi, Shabnam Abtahi
Mesenchymal Stem Cells (MSCs) are a heterogeneous population of fibroblast-like cells which maintain self-renewability and pluripotency to differentiate into mesodermal cell lineages. The use of MSCs in clinical settings began with high enthusiasm and the number of MSC-based clinical trials has been rising ever since. However; the very unique characteristics of MSCs that made them suitable to for therapeutic use, might give rise to unwanted outcomes, including tumor formation and progression. In this paper, we present a model of carcinogenesis initiated by MSCs, which chains together the tissue organization field theory, the stem cell theory, and the inflammation-cancer chain...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29728886/development-of-a-novel-large-animal-model-to-evaluate-human-dental-pulp-stem-cells-for-articular-cartilage-treatment
#17
Tiago Lazzaretti Fernandes, Kazunori Shimomura, Andre Asperti, Carla Cristina Gomes Pinheiro, Heloísa Vasconcellos Amaral Caetano, Claudia Regina G C M Oliveira, Norimasa Nakamura, Arnaldo José Hernandez, Daniela Franco Bueno
PURPOSE: Chondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. The ability of human Dental Pulp Stem Cells (DPSCs) to differentiate into chondroblasts in vitro suggests that this stem cell type may be useful for tissue bioengineering. However, we have yet to identify a study of large animal models in which DPSCs were used to repair articular cartilage. Therefore, this study aimed to describe a novel treatment for cartilage lesion with DPSCs on a large animal model...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29707747/comparison-of-human-denuded-amniotic-membrane-and-porcine-small-intestine-submucosa-as-scaffolds-for-limbal-mesenchymal-stem-cells
#18
Liliana I Sous Naasani, Cristiano Rodrigues, Jéssica Gonçalves Azevedo, Aline F Damo Souza, Silvio Buchner, Márcia R Wink
Blinding corneal scarring is usually treated with allogeneic graft tissue. Nevertheless, the global shortage of donors leaves millions of patients in need of therapy. Traditional tissue engineering strategies involves the combination of cells, growth factors, and scaffolds that can supply cellular biological components allowing to restore the tissue function. The mesenchymal stem cells found in the limbal stroma (L-MSCs) have a self-renewal potential for multilineage differentiation. Thus, in this work we compared the potential of human amniotic membrane (hAM) and porcine small intestine submucosa (SIS) as scaffolds for L-MSCs, aiming at potential applications in corneal regeneration...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29691795/improved-protocol-for-chondrogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-effect-of-pthrp-and-fgf-2-on-tgf%C3%AE-1-bmp2-induced-chondrocytes-hypertrophy
#19
Davood Nasrabadi, Siamak Rezaeiani, Mohamadreza Baghaban Eslaminejad, Aliakbar Shabani
Growth factors have a pivotal role in chondrogenic differentiation of stem cells. The differential effects of known growth factors involved in the maintenance and homeostasis of cartilage tissue have been previously studied in vitro. However, there are few reported researches about the interactional effects of growth factors on chondrogenic differentiation of stem cells. The aim of this study is to examine the combined effects of four key growth factors on chondrogenic differentiation of mesenchymal stem cells (MSCs)...
October 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29802508/mulhouse-strategy-to-expand-ex-vivo-very-small-embryonic-like-stem-cells-vsels-recent-study-published-in-stem-cell-reviews-and-reports
#20
EDITORIAL
Mariusz Z Ratajczak
No abstract text is available yet for this article.
August 2018: Stem Cell Reviews
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