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Stem Cell Reviews

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https://www.readbyqxmd.com/read/28210846/stem-cell-reviews-and-reports-cell-trafficking-stem-cell-mobilization-and-homing-and-hematopoiesis-section
#1
EDITORIAL
Louis M Pelus
No abstract text is available yet for this article.
February 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28205001/stem-cell-reviews-and-reports-new-directions-and-developments-a-letter-from-the-editor-in-chief
#2
EDITORIAL
Mariusz Z Ratajczak
No abstract text is available yet for this article.
February 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28188496/stem-cell-reviews-and-reports-cancer-stem-cells-and-aging-section
#3
EDITORIAL
Peter Quesenberry
No abstract text is available yet for this article.
February 10, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28168349/stem-cell-reviews-and-reports-induced-pluripotent-stem-cells-embryonic-stem-cells-and-development-section
#4
EDITORIAL
Henning Ulrich
No abstract text is available yet for this article.
February 6, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28161856/stem-cell-reviews-and-reports-microenvironment-and-extracellular-microvesicles-section
#5
EDITORIAL
Giovanni Camussi
No abstract text is available yet for this article.
February 4, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28154962/expression-of-desmoglein-2-desmocollin-3-and-plakophilin-2-in-placenta-and-bone-marrow-derived-mesenchymal-stromal-cells
#6
Melanie L Hart, Elisa Rusch, Marvin Kaupp, Kay Nieselt, Wilhelm K Aicher
Many controversial results exist when comparing mesenchymal stromal cells (MSCs) derived from different sources. Reasons include not only variables in tissue origin, but also methods of cell preparation or choice of expansion media which can strongly influence the expression and hence, function of the cells. In this short report we aimed to investigate the expression of the cell anchoring proteins desmoglein 2, desmocollin 3 and plakophilin 2 in early passage placenta-derived MSCs of fetal (fetal pMSCs) and maternal (maternal pMSCs) origins versus adult bone marrow-derived MSCs (bmMSCs) that were expanded and cultured under the same good manufacturing practice (GMP) conditions...
February 2, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28120159/effect-of-cell-seeding-density-and-inflammatory-cytokines-on-adipose-tissue-derived-stem-cells-an-in-vitro-study
#7
Panithi Sukho, Jolle Kirpensteijn, Jan Willem Hesselink, Gerjo J V M van Osch, Femke Verseijden, Yvonne M Bastiaansen-Jenniskens
Adipose tissue-derived stem cells (ASCs) are known to be able to promote repair of injured tissue via paracrine factors. However, the effect of cell density and inflammatory cytokines on the paracrine ability of ASCs remains largely unknown. To investigate these effects, ASCs were cultured in 8000 cells/cm(2), 20,000 cells/cm(2), 50,000 cells/cm(2), and 400,000 cells/cm(2) with and without 10 or 20 ng/ml tumor necrosis factor alpha (TNFα) and 25 or 50 ng/ml interferon gamma (IFNγ). ASC-sheets formed at 400,000 cells/cm(2) after 48 h of culture...
January 24, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28101702/bone-marrow-very-small-embryonic-like-stem-cells-new-generation-of-autologous-cell-therapy-soon-ready-for-prime-time
#8
EDITORIAL
David M Smadja
Very small embryonic-like stem cells (VSELs) are major pluripotent stem cells described in human and mouse. In this issue of Stem Cell Reviews and Reports, Shaikh and colleagues show in a valuable work that mouse bone marrow collected after 5FU treatment contains VSELs able to undergo in vitro multi-lineage differentiation into cells from all three germ layers and also in germ and hematopoietic cells. These findings are robust since no confounding factor such as feeder cell fusion with VSELs can occur here...
January 18, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28083784/understanding-parkinson-s-disease-through-the-use-of-cell-reprogramming
#9
REVIEW
Rebecca Playne, Bronwen Connor
Recent progress in the field of somatic cell reprogramming offers exciting new possibilities for the study and treatment of Parkinson's disease (PD). Reprogramming technology offers the ability to untangle the diverse contributing risk factors for PD, such as ageing, genetics and environmental toxins. In order to gain novel insights into such a complex disease, cell-based models of PD should represent, as closely as possible, aged human dopaminergic neurons of the substantia nigra. However, the generation of high yields of functionally mature, authentic ventral midbrain dopamine (vmDA) neurons has not been easy to achieve...
January 12, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28070859/mouse-bone-marrow-vsels-exhibit-differentiation-into-three-embryonic-germ-lineages-and-germ-hematopoietic-cells-in-culture
#10
Ambreen Shaikh, Sandhya Anand, Sona Kapoor, Ranita Ganguly, Deepa Bhartiya
Very small embryonic-like stem cells (VSELs) have been reported in various adult tissues, express pluripotent and primordial germ cells (PGCs) specific markers, are mobilized under stress/disease conditions, give rise to tissue committed progenitors and thus help regenerate and maintain homeostasis. The aim of the present study was to evaluate in vitro differentiation potential of VSELs using a quantitative approach. VSELs were collected from mouse bone marrow after 4 days of 5-fluorouracil (5-FU, 150 mg/Kg) treatment, further enriched by size based filtration and cultured on a feeder support in the presence of specific differentiation media...
January 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28070858/exosome-and-microvesicle-enriched-fractions-isolated-from-mesenchymal-stem-cells-by-gradient-separation-showed-different-molecular-signatures-and-functions-on-renal-tubular-epithelial-cells
#11
Federica Collino, Margherita Pomatto, Stefania Bruno, Rafael Soares Lindoso, Marta Tapparo, Wen Sicheng, Peter Quesenberry, Giovanni Camussi
Several studies have suggested that extracellular vesicles (EVs) released from mesenchymal stem cells (MSCs) may mediate MSC paracrine action on kidney regeneration. This activity has been, at least in part, ascribed to the transfer of proteins/transcription factors and different RNA species. Information on the RNA/protein content of different MSC EV subpopulations and the correlation with their biological activity is currently incomplete. The aim of this study was to evaluate the molecular composition and the functional properties on renal target cells of MSC EV sub-populations separated by gradient floatation...
January 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28064388/stem-cell-recipes-of-bone-marrow-and-fish-just-what-the-stroke-doctors-ordered
#12
REVIEW
Eleonora Napoli, Cesar V Borlongan
Stem cell therapy for stroke has advanced from the laboratory to the clinic, but remains as an experimental treatment. Two lines of transplant regimens have emerged, namely the "early bird" peripheral injections in subacute stroke patients and the "late night" direct intracerebral treatments in chronic stroke patients. Autologous bone marrow-derived stem cells, which only required minimal manipulations during graft cell preparation, gained fast-track entry into the clinic, while gene modified stem cells necessitated overcoming more stringent regulatory criteria before they were approved for clinical use...
January 7, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28063063/identifying-candidate-reprogramming-genes-in-mouse-induced-pluripotent-stem-cells
#13
Fang Gao, Jingyu Li, Heng Zhang, Xu Yang, Tiezhu An
Factor-based induced reprogramming approaches have tremendous potential for human regenerative medicine, but the efficiencies of these approaches are still low. In this study, we analyzed the global transcriptional profiles of mouse induced pluripotent stem cells (miPSCs) and mouse embryonic stem cells (mESCs) from seven different labs and present here the first successful clustering according to cell type, not by lab of origin. We identified 2131 different expression genes (DEs) as candidate pluripotency-associated genes by comparing mESCs/miPSCs with somatic cells and 720 DEs between miPSCs and mESCs...
January 6, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28058671/possible-muscle-repair-in-the-human-cardiovascular-system
#14
REVIEW
Linda Sommese, Alberto Zullo, Concetta Schiano, Francesco P Mancini, Claudio Napoli
The regenerative potential of tissues and organs could promote survival, extended lifespan and healthy life in multicellular organisms. Niches of adult stemness are widely distributed and lead to the anatomical and functional regeneration of the damaged organ. Conversely, muscular regeneration in mammals, and humans in particular, is very limited and not a single piece of muscle can fully regrow after a severe injury. Therefore, muscle repair after myocardial infarction is still a chimera. Recently, it has been recognized that epigenetics could play a role in tissue regrowth since it guarantees the maintenance of cellular identity in differentiated cells and, therefore, the stability of organs and tissues...
January 5, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28054239/the-protein-content-of-extracellular-vesicles-derived-from-expanded-human-umbilical-cord-blood-derived-cd133-and-human-bone-marrow-derived-mesenchymal-stem-cells-partially-explains-why-both-sources-are-advantageous-for-regenerative-medicine
#15
Addeli B B Angulski, Luiz G Capriglione, Michel Batista, Bruna H Marcon, Alexandra C Senegaglia, Marco A Stimamiglio, Alejandro Correa
Adult stem cells have beneficial effects when exposed to damaged tissue due, at least in part, to their paracrine activity, which includes soluble factors and extracellular vesicles (EVs). Given the multiplicity of signals carried by these vesicles through the horizontal transfer of functional molecules, human mesenchymal stem cell (hMSCs) and CD133(+) cell-derived EVs have been tested in various disease models and shown to recover damaged tissues. In this study, we profiled the protein content of EVs derived from expanded human CD133(+) cells and bone marrow-derived hMSCs with the intention of better understanding the functions performed by these vesicles/cells and delineating the most appropriate use of each EV in future therapeutic procedures...
January 4, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28050756/endothelial-cell-mediated-promotion-of-ciliated-cell-differentiation-of-human-airway-basal-cells-via-insulin-and-insulin-like-growth-factor-1-receptor-mediated-signaling
#16
Kazunori Gomi, Yongjiang Tang, Vanessa Arbelaez, Ronald G Crystal, Matthew S Walters
Human airway basal cells (BC) function as stem/progenitor cells of the human airway epithelium, capable of differentiating into ciliated and secretory cells during turnover and repair. The positioning of BC along the basement membrane allows for potential paracrine signaling from non-epithelial cells in the mesenchyme to regulate BC function. Based on the knowledge that interaction between the airway epithelium and mesenchyme is critical for proper maintenance of both tissues, and that endothelial cells (EC) can regulate multiple functions of BC, the present study was designed to help understand the role of BC and EC cross-talk in regulating BC stem/progenitor function...
January 3, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28000155/hepatocyte-nuclear-factor-4-alpha-promotes-definitive-endoderm-differentiation-from-human-induced-pluripotent-stem-cells
#17
Morifumi Hanawa, Kazuo Takayama, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
Hepatocyte nuclear factor 4 alpha (HNF4α) is a key transcription factor for liver development. Although HNF4α is necessary for hepatoblast differentiation, the function of HNF4α before the hepatoblast differentiation, such as in definitive endoderm differentiation, is not well known. In addition, it is known that there are nine HNF4α isoforms, but the expression and function of each HNF4α isoform during the definitive endoderm differentiation is also not clear. In this study, we examined the expression pattern of HNF4α and its functions in the definitive endoderm differentiation from human induced pluripotent stem (iPS) cells...
December 21, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27987073/comparison-of-four-protocols-to-generate-chondrocyte-like-cells-from-human-induced-pluripotent-stem-cells-hipscs
#18
Wiktoria Maria Suchorska, Ewelina Augustyniak, Magdalena Richter, Tomasz Trzeciak
Stem cells (SCs) are a promising approach to regenerative medicine, with the potential to treat numerous orthopedic disorders, including osteo-degenerative diseases. The development of human-induced pluripotent stem cells (hiPSCs) has increased the potential of SCs for new treatments. However, current methods of differentiating hiPSCs into chondrocyte-like cells are suboptimal and better methods are needed. The aim of the present study was to assess four different chondrogenic differentiation protocols to identify the most efficient method of generating hiPSC-derived chondrocytes...
December 16, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27924617/cxcl12-sdf-1-dependent-retinal-migration-of-endogenous-bone-marrow-derived-stem-cells-improves-visual-function-after-pharmacologically-induced-retinal-degeneration
#19
Volker Enzmann, Stéphanie Lecaudé, Anna Kruschinski, Axel Vater
Mobilized bone marrow-derived stem cells (BMSC) have been discussed as an alternative strategy for endogenous repair. Thereby, different approaches for BMSC mobilization have been pursued. Herein, the role of a newly discovered oligonucleotide for retinal homing and regeneration capability of BMSCs was investigated in the sodium iodate (NaIO3) model of retinal degeneration. Mobilization was achieved in GFP-chimera with NOX-A12, a CXC-motif chemokine ligand 12 (CXCL12)/stromal cell-derived factor 1 (SDF-1)-neutralizing L-aptamer...
December 6, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27921202/endogenous-stem-cells-were-recruited-by-defocused-low-energy-shock-wave-in-treating-diabetic-bladder-dysfunction
#20
Yang Jin, Lina Xu, Yong Zhao, Muwen Wang, Xunbo Jin, Haiyang Zhang
Defocused low-energy shock wave (DLSW) has been shown effects on activating mesenchymal stromal cells (MSCs) in vitro. In this study, recruitment of endogenous stem cells was firstly examined as an important pathway during the healing process of diabetic bladder dysfunction (DBD) treated by DLSW in vivo. Neonatal rats received intraperitoneal injection of 5-ethynyl-2-deoxyuridine (EdU) and then DBD rat model was created by injecting streptozotocin. Four weeks later, DLSW treatment was performed. Afterward, their tissues were examined by histology...
December 5, 2016: Stem Cell Reviews
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