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Breast Care

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https://www.readbyqxmd.com/read/28559771/cdk4-6-inhibitors-in-the-treatment-of-metastatic-breast-cancer
#1
Johannes Ettl, Jens Huober, Diana Lüftner, Frederik Marmé, Rachel Würstlein
No abstract text is available yet for this article.
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559770/erratum
#2
(no author information available yet)
[This corrects the article on p. 432 in vol. 11.].
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559769/next-generation-sequencing-reveals-a-nonsense-mutation-p-arg364ter-in-mre11a-gene-in-an-indian-patient-with-familial-breast-cancer
#3
Pratibha Sharma Bhai, Deepak Sharma, Renu Saxena, Ishwar C Verma
BACKGROUND: The MRN complex consisting of MRE11A-RAD50-NBS1 proteins is involved in the repair of double-strand breaks, and mutations in genes coding for the MRN complex have been identified in families with breast and ovarian cancer. CASE REPORT: In a BRCA-negative family with positive history of breast and endometrial cancer, next-generation sequencing-based panel testing identified a mutation in the MRE11A gene (NM_005590 c.1090C>T: p.Arg364Ter). This mutation results in a shorter mutated protein lacking 2 DNA binding domains (the GAR domain and the RAD50 binding site), abolishing the function of protein...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559768/intraoperative-radiotherapy-of-breast-cancer-and-its-biological-effects
#4
REVIEW
Igor Piotrowski, Katarzyna Kulcenty, Mateusz Wichtowski, Dawid Murawa, Wiktoria Suchorska
Conservative breast cancer surgery followed by radiation therapy is the standard treatment for this type of cancer. Numerous studies demonstrate that 90% of local recurrences after traditional surgery occur in the same quadrant as the primary cancer. The published data suggest that the wound healing process after surgery alters the area surrounding the original tumor and the modified microenvironment is more favorable for the tumor to recur. The majority of metastases within scar initiated much research, and the consequences of these studies led to clinical trials aimed at assessing whether localized radiotherapy, such as intraoperative radiotherapy (IORT), would be more effective in inhibiting formation of local recurrence than the standard postoperative whole breast radiotherapy...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559767/st-gallen-vienna-2017-a-brief-summary-of-the-consensus-discussion-about-escalation-and-de-escalation-of-primary-breast-cancer-treatment
#5
REVIEW
Michael Gnant, Nadia Harbeck, Christoph Thomssen
For the second time, the St. Gallen Consensus Conference on early breast cancer treatment standards took place in Vienna, Austria, where it will remain for the foreseeable future (next date: March 20-23, 2019). With the probably most prominent line-up of global breast cancer experts and more than 3,000 participants from over 100 countries, the 2017 St. Gallen/Vienna conference again was a huge success. A generation change took place with respect to the Conference Co-Chairpersons. Traditionally, the experts from all continents reviewed publications from the past 2 years, and discussed whether new diagnostic or therapeutic means were ready for routine everyday practice...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559766/combining-virtual-touch-tissue-imaging-and-bi-rads-may-improve-solid-breast-lesion-evaluation
#6
Size Wu, Xiaojing Cui, Li Huang, Xuefei Bai
BACKGROUND: Ultrasound elastography (UE) is a novel imaging method. The purpose of this study was to determine the utility of Virtual Touch tissue imaging in the evaluation of solid breast lesions. PATIENTS AND METHODS: 209 breast solid lesions in 192 patients that had been evaluated using ultrasound (US) and UE were reviewed and analyzed. RESULTS: The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for UE, US, and US plus UE in the differentiation of malignant from benign breast lesions were 80...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559765/value-of-digital-breast-tomosynthesis-versus-additional-views-for-the-assessment-of-screen-detected-abnormalities-a-first-analysis
#7
Sylvia Heywang-Köbrunner, Alexander Jaensch, Astrid Hacker, Sabina Wulz-Horber, Thomas Mertelmeier, Dieter Hölzel
BACKGROUND: The purpose of this study was to countercheck the equivalence of single-view digital breast tomosynthesis (DBT) or DBT with additional views (DBT+AV) compared to traditional standard assessment by additional views (AV) in patients with a screen-detected abnormality. PATIENTS AND METHODS: Patients with a screen-detected abnormality were consecutively invited to obtain 1 single-view wide-angle DBT in addition to the indicated AV. The study was approved by the local ethics committee and by the Federal Office for Radiation Protection...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559764/factors-affecting-concordance-between-radiological-and-histological-findings-in-invasive-lobular-carcinoma-experience-from-a-national-cancer-centre
#8
Duaa Abu-Sinn, Donal O'Driscoll, Maurice Murphy
BACKGROUND: Invasive lobular carcinoma (ILC) is characterized by an infiltrative discohesive growth pattern, making it difficult to accurately assess both clinically and by imaging studies. Despite favourable biological characteristics, challenges remain in the surgical treatment of ILC. We aimed to evaluate radiology/histology concordance and identify histological and biological parameters on core biopsies that may predict final tumour histology and guide surgical treatment decisions...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559763/financial-toxicity-of-cancer-drugs-possible-remedies-from-an-ethical-perspective
#9
Georg Marckmann, Jürgen In der Schmitten
Spiraling costs of cancer treatments have become a major concern for the payers in the health care system and for individual patients suffering from the cancer drugs' financial toxicity. This article discusses possible solutions from an ethical perspective. First, it gives some orientation about what constitutes a fair price for innovative anticancer agents. While a definitive answer remains difficult, there are good reasons to enter into price negotiations with the pharmaceutical companies to align the price with the R&D costs and the added value of the product...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28559762/accurate-measurement-of-financial-toxicity-is-a-prerequisite-to-finding-a-remedy
#10
EDITORIAL
Adam Martin, Peter S Hall
No abstract text is available yet for this article.
May 2017: Breast Care
https://www.readbyqxmd.com/read/28611544/erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611543/san-antonio-2016-progress-on-the-long-way-to-individualized-treatment-of-breast-cancer
#12
Volkmar Müller, Oleg Gluz, Jean-Yves Pierga, Marc Thill, Brigitte Rack, Isabell Witzel
No abstract text is available yet for this article.
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611542/protecting-effects-of-gonadotropin-releasing-hormone-agonist-on-chemotherapy-induced-ovarian-damage-in-premenopausal-breast-cancer-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
Fang Bai, Yunshu Lu, Kejin Wu, Qing Chen, Longlong Ding, Meixin Ge, Ziyi Weng
OBJECTIVE: There is no universal consensus on whether gonadotropin-releasing hormone (GnRH) agonist could protect chemotherapy-induced ovarian damage in premenopausal breast cancer patients. This meta-analysis was conducted to estimate the protective effects of GnRH agonist on premenopausal breast cancer patients in details. METHODS: PubMed, Cochrane Library, Embase, CNKI and the Chinese Wangfang Database, conference proceedings and clinical trials were searched to find studies reported since 2000...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611541/effectiveness-of-pertuzumab-trastuzumab-and-docetaxel-combination-neoadjuvant-chemotherapy-for-her2-positive-inflammatory-breast-cancer-a-case-report
#14
Yuji Yamashita, Yuko Tanaka, Seishi Kono, Meiko Nishimura, Toru Mukohara, Yukiko Morinaga, Shigeo Hara, Shintaro Takao
BACKGROUND: Inflammatory breast cancer (IBC) is the most aggressive form of primary breast cancer. CASE REPORT: A 40-year-old woman was referred to our hospital for evaluation of an induration in the right breast, suspected to be breast cancer. The tumor was diagnosed as estrogen receptor-negative, progesterone receptor-negative, HER2-positive, T4dN3cM0 stage IIIc IBC with axillary lymph node metastasis. Rather than surgical intervention, we chose a systemic treatment approach with pertuzumab, trastuzumab, and docetaxel (PTD) combination therapy which was shown to be effective for HER2-positive IBC in the NeoSphere trial...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611540/evaluation-of-qtc-interval-prolongation-in-breast-cancer-patients-after-treatment-with-epirubicin-cyclophosphamide-and-docetaxel-and-the-influence-of-interobserver-variation
#15
Julian Puppe, Deborah van Ooyen, Jeanne Neise, Fabinshy Thangarajah, Christian Eichler, Stefan Krämer, Roman Pfister, Peter Mallmann, Marina Wirtz, Guido Michels
BACKGROUND: Chemotherapy with anthracyclines is associated with life-threatening electrocardiographic alterations including corrected QT (QTc) interval prolongation. PATIENTS AND METHODS: In this study we assessed the effect of epirubicin, cyclophosphamide, and docetaxel (EC-Doc) on the QTc interval in 10 patients with early breast cancer. Cardiac toxicity was assessed with symptoms, transthoracic echocardiography, electrocardiography (ECG), and serum cardiac markers at baseline and after 4 cycles of EC and 4 cycles of docetaxel...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611539/using-anchoring-vignettes-in-the-evaluation-of-breast-cancer-survivors-quality-of-life
#16
Andreas Hinz
BACKGROUND: Breast cancer survivors often rate their general health as good even though they experience detriments in functioning and multiple symptoms. The hypothesis of this study is that breast cancer survivors changed their frames of reference for evaluating their own health. METHODS: A sample of 308 breast cancer survivors were asked to assess their state of health on a 0-100 scale. In addition, 2 vignettes (fictional persons suffering from various health complaints) were designed...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611538/breast-conserving-surgery-under-local-anesthesia-in-elderly-patients-with-severe-cardiorespiratory-comorbidities-a-hospital-based-case-control-study
#17
Hasan Karanlik, Berkay Kılıç, Ilknur Yıldırım, Süleyman Bademler, Ilker Ozgur, Burak Ilhan, Semen Onder
INTRODUCTION: We report the feasibility and safety of local anesthesia (LA) in patients having breast-conserving surgery (BCS). METHODS: 37 patients with American Society of Anesthesiologists (ASA) score of 4 having BCS under LA and 54 age-matched subjects with ASA score of 3-4 having BCS under general anesthesia (GA) were included. Patients were retrospectively evaluated for the follow-up duration, duration of surgery, postoperative satisfaction scores (1-10), complication and survival time for locoregional recurrence and overall survival rates...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611537/therapeutic-advances-and-new-directions-for-triple-negative-breast-cancer
#18
REVIEW
Eleni Andreopoulou, Catherine M Kelly, Hayley M McDaid
Triple-negative breast cancer (TNBC) is a molecularly diverse grouping with poor prognosis for which chemotherapy remains the foundation of treatment. The molecular heterogeneity of the disease rationalizes its diverse biological behavior and differential response to treatment. Estimates of up to 20% of patients diagnosed have germline mutations in DNA-damage repair-pathway genes, namely BRCA1 and 2, and this can be used to select patients likely to respond to platinums and/or inhibitors of poly(ADP-ribose) polymerase (PARP)...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611536/germline-mutations-in-triple-negative-breast-cancer
#19
REVIEW
Eric Hahnen, Jan Hauke, Christoph Engel, Guido Neidhardt, Kerstin Rhiem, Rita K Schmutzler
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and defines a subgroup of patients who do not benefit from endocrine or anti-HER2 therapy. Rather than being a biological entity, TNBC represents a heterogeneous disease, and further subtyping is necessary to establish targeted therapies. Germline mutational status may serve as a robust biomarker predicting therapy response, especially with respect to compounds challenging the DNA repair machinery. Patients with TNBC usually show an early onset of the disease, as well as a positive family history of breast and/or ovarian cancer in more than one third of all cases, which suggests that TNBC is closely associated with a hereditary disease cause...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611535/biological-subtypes-of-triple-negative-breast-cancer
#20
REVIEW
Michael Hubalek, Theresa Czech, Hannes Müller
Triple-negative breast cancers (TNBCs) are defined as tumors that are negative for estrogen, progesterone and HER-2 receptor. At a percentage of 10-20% TNBCs represent a minority in all breast cancers. However, because of the poor prognosis this particular subtype, triple negative disease accounts for a disproportionate number of metastatic cases and breast cancer deaths. Identification of its subtypes is essential for understanding the biological characteristics and clinical behavior of TNBC, as well as for developing personalized treatments...
March 2017: Breast Care
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