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Breast Care

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https://www.readbyqxmd.com/read/29887793/molecular-tumor-boards
#1
Achim Rody, Johannes Ettl, Frederik Marmé, Aleix Prat
No abstract text is available yet for this article.
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887792/a-clinical-observation-of-thymic-epithelial-tumor-metastatic-to-breast
#2
Yu-Wei Deng, Yi-Wen Li, Wen-Jing Hao, Dan Lu
Background: Thymic carcinoma is prone to early metastasis and invasion, while its metastasis to the breast is particularly unique. Case Report: We describe a case of thymic epithelial tumor metastatic to the breast fulfilling clinical diagnostic criteria. A 47-year-old female patient diagnosed with stage IV thymic carcinoma and previously treated with chemoradiation was diagnosed with metastatic breast cancer during a periodic review. Color Doppler ultrasonography showed a low-echo real occupancy in the breast...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887791/axillary-web-syndrome-in-breast-cancer-a-prevalent-but-under-recognized-postoperative-complication
#3
REVIEW
Susan R Harris
The purpose of this review is to define axillary web syndrome (AWS) and describe its diagnosis and management. The following databases were searched through July 2017: PubMed, EMBASE (OvidSP), Cumulative Index for Nursing and Allied Health Literature, Physiotherapy Evidence Database, and Cochrane Database of Systematic Reviews. Search terms included 'axillary web syndrome', 'axillary cording', and 'lymphatic cording'. 49 articles were identified; 8 did not relate to breast cancer, and 3 were not in English...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887790/evaluation-of-reproductive-concerns-and-biographical-impact-of-breast-cancer-in-young-patients
#4
Maximiliane Burgmann, Kerstin Hermelink, Alex Farr, Friederike van Meegen, Annika Heiduschk, Jutta Engel, Thomas Kolben, Tom Degenhardt, Nina Ditsch, Sven Mahner, Nadia Harbeck, Rachel Würstlein
Background: This study evaluates interventions offered to young breast cancer (BC) patients, including fertility preservation, genetic testing, and counseling for parenthood concerns, and analyzes the effect of BC on biographical issues. Methods: Women who were diagnosed with BC at the age of 18-40 years and who underwent treatment at the Breast Center, Ludwig-Maximilian University (LMU) in Munich between 2006 and 2013, were eligible for this study. Patients received a self-developed questionnaire which covered the following topics: fertility preservation, family planning, genetic testing, parenthood concerns and children's needs, partnership status, and employment situation...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887789/toxicities-associated-with-docetaxel-based-regimens-in-the-adjuvant-treatment-of-early-stage-breast-cancer-a-multicenter-prospective-real-life-experience
#5
Elie El Rassy, Marwan Ghosn, Fadi Farhat, Ziad Bakouny, Tarek Assi, Georges Chahine, Fadi Nasr, Fady Ghassan Haddad, Fadi El Karak, Joseph Kattan
Background: The present study reports on the efficacy and safety of adjuvant docetaxel in real-life patients with early-stage breast cancer. Methods: This is a prospective, multicenter, post-marketing study that evaluates the efficacy and safety of docetaxel-based regimens in patients with early breast cancer treated between 2007 and 2012. Results: A total of 698 female breast cancer patients receiving adjuvant docetaxel-based regimens were included in this study...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887788/using-a-new-marker-clip-system-in-breast-cancer-tumark-vision%C3%A2-clip-feasibility-testing-in-everyday-clinical-practice
#6
Anna Marlene Rüland, Friederike Hagemann, Mattea Reinisch, Johannes Holtschmidt, Aylin Kümmel, Christine Dittmer-Grabowski, Frank Stöblen, Horst Rotthaus, Volker Dreesmann, Jens-Uwe Blohmer, Sherko Kümmel
Background: This study presents first feasibility experiences with a new 3-dimensional (3D) marker clip system in clinical practice. The rate of clinical complete responses in the treatment of breast cancer patients is increasing; additionally, a change to targeted axillary dissection is being considered after neoadjuvant chemotherapy (NACT). Consequently, marker clips are needed which are reliable and easy to handle even in the axillary lymph node system. Methods: A total of 50 patients from the Breast Care Unit of the Kliniken Essen Mitte were included...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887787/modifiable-lifestyle-factors-opportunities-for-hereditary-breast-cancer-prevention-a-narrative-review
#7
REVIEW
Jacqueline Lammert, Sabine Grill, Marion Kiechle
Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887786/mindfulness-in-follow-up-care-after-breast-cancer-can-it-prevent-recurrence
#8
REVIEW
Carola Modica, Klaus Hoenig
This review focuses on the question whether mindfulness in follow-up care can contribute to the prevention of breast cancer (BC) recurrence. We first introduce behavioral risk and protective factors in follow-up care by presenting current research outcomes modulating individual risk for recurrence. We argue that although increased self-awareness is undoubtedly beneficial for BC survivors, it may also trigger adverse effects in vulnerable individuals such as overarousal and impaired emotional regulation. Indeed, research shows that many BC survivors are often confronted with clinical levels of fear of recurrence and anxiety and depressive symptoms...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887785/physical-activity-exercise-and-breast-cancer-what-is-the-evidence-for-rehabilitation-aftercare-and-survival-a-review
#9
REVIEW
Petra Wirtz, Freerk T Baumann
The current scientific field of exercise interventions in breast cancer is very large. Rehabilitation focuses on restoring or improving quality of life and thus on independence and participation in life. Hence, it is important to investigate exercise interventions in the setting of rehabilitation and aftercare. It is also necessary to determine the influence of physical activity or exercise therapy on the prevention of recurrence and mortality as well as on certain side effects of the disease and its medical treatment in rehabilitation...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887784/can-nutrition-lower-the-risk-of-recurrence-in-breast-cancer
#10
REVIEW
Julia Weigl, Hans Hauner, Dagmar Hauner
Background: The impact of diet on breast cancer prognosis is poorly understood. Therefore, we conducted a literature search summarizing the current evidence on the effect of diet on breast cancer recurrence and mortality. Methods: The PubMed database was searched for original studies, reviews, and meta-analyses published between 2010 and 2017. Studies related to diet, dietary patterns, special diets or specific dietary factors, and breast cancer recurrence or mortality were included...
April 2018: Breast Care
https://www.readbyqxmd.com/read/29887783/breast-cancer-a-lifestyle-disease
#11
EDITORIAL
Wolfgang Janni
No abstract text is available yet for this article.
April 2018: Breast Care
https://www.readbyqxmd.com/read/29950968/abc4-consensus-assessment-by-a-german-group-of-experts
#12
Nadia Harbeck, Diana Lüftner, Norbert Marschner, Michael Untch, Doris Augustin, Susanne Briest, Johannes Ettl, Renate Haidinger, Lothar Müller, Volkmar Müller, Eugen Ruckhäberle, Rachel Wuerstlein, Christoph Thomssen
The Advanced Breast Cancer Fourth Consensus (ABC4) on diagnosis and treatment of advanced breast cancer (ABC) again took place in Lisbon, on November 2-4, 2017, and was chaired by Fatima Cardoso, MD, PhD. This year's contents focused very much on new developments in the treatment of ABC. For example, the significance of inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) in hormone receptor (HR)-positive ABC, of dual antibody blockade in human epidermal growth factor receptor 2 (HER2)-positive ABC, and of poly(ADP-ribose) polymerase (PARP) inhibition in triple-negative ABC, as well as the potential therapeutic consequences, were discussed...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950967/dystrophic-calcifications-in-the-breast-from-secondary-hyperparathyroidism
#13
Kyoung Min Lee, Jee Eun Lee, Eun Suk Cha, Jin Chung, Jeoung Hyun Kim, Byung In Moon
Background: Soft tissue calcification is common in patients with secondary hyperparathyroidism who have received long-term treatment with hemodialysis. However, calcifications in the breast parenchyma are not common. We report a case of a woman with dystrophic breast calcifications from secondary hyperparathyroidism. Case Report: A 65-year-old woman presented with a palpable mass in her right breast which she had discovered 1 month ago. She had a medical history of end-stage renal disease...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950966/why-do-women-with-breast-cancer-get-diagnosed-and-treated-late-in-sub-saharan-africa-perspectives-from-women-and-patients-in-bamako-mali
#14
Kirstin Grosse Frie, Hatouma Samoura, Samba Diop, Bakarou Kamate, Cheick Bougadari Traore, Brahima Malle, Bourama Coulibaly, Eva Johanna Kantelhardt
Background: Breast cancer, the most common cancer among women worldwide, has a high mortality rate in low-income countries. In sub-Saharan Africa, most breast cancer patients are diagnosed with advanced disease. Some studies have quantified the time delay to diagnosis in sub-Saharan Africa, but very few have used qualitative methods to understand barriers leading to delay. This study analyses barriers throughout a breast cancer patient's pathway from symptom recognition to treatment in Mali...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950965/differentiation-between-pure-mucinous-breast-carcinomas-and-fibroadenomas-with-strong-high-signal-intensity-on-t2-weighted-images-from-dynamic-contrast-enhanced-magnetic-resonance-imaging
#15
Ning Qu, Yahong Luo, Tao Yu, Huihui Yu
Objective: This study aimed to identify characteristics that can differentiate between pure mucinous breast carcinomas (PMBCs) and fibroadenomas (FAs) with strong high-signal intensity on T2-weighted images (T2-SHi) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods: The DCE-MRI tumor characteristics were compared and analyzed between 35 PMBCs and 70 FAs with T2-SHi. Results: Multivariate analysis revealed that delayed enhancement pattern was the only significant independent predictor (p = 0...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950964/checkpoint-inhibitors-in-breast-cancer-current-status-and-future-directions
#16
REVIEW
Joachim Bischoff
Antineoplastic agents directly targeting tumor cells have represented the major strategy of systemic anticancer therapy for many years. Nevertheless, overcoming resistance mechanisms remains a great challenge because treatment options are limited in many cases. From this point of view, immunotherapeutic approaches seem promising in a broad spectrum of solid tumors. These include in particular the currently available inhibitors directed against immune checkpoints leading to a significant T-cell activation. To date, the programmed death receptor 1 (PD-1) and its ligand are the most prominent targets in this context...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950963/immunooncology-in-breast-cancer-active-and-passive-vaccination-strategies
#17
REVIEW
Florian Schütz, Frederik Marmé, Christoph Domschke, Christof Sohn, Alexandra von Au
Immunotherapies are set to become part of the therapeutic repertoire for breast cancer in the near future. Active vaccination is a promising strategy, especially in tumors that have a specific tumor-associated antigen. Although cellular immunotherapies have not yet shown efficacy, new technologies are on the way to improve this approach. Given the recent Food and Drug Administration approval of chimeric antigen receptor (CAR) T cells for leukemia, it is only a question of time before solid tumors will follow...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950962/the-role-of-immune-escape-and-immune-cell-infiltration-in-breast-cancer
#18
REVIEW
André Steven, Barbara Seliger
While detailed analysis of aberrant cancer cell signaling pathways and changes in cancer cell DNA has dominated the field of breast cancer biology for years, there now exists increasing evidence that the tumor microenvironment (TME) including tumor-infiltrating immune cells support the growth and development of breast cancer and further facilitate invasion and metastasis formation as well as sensitivity to drug therapy. Furthermore, breast cancer cells have developed different strategies to escape surveillance from the adaptive and innate immune system...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950961/tilgen-a-program-to-investigate-immune-targets-in-breast-cancer-patients-first-results-on-the-influence-of-tumor-infiltrating-lymphocytes
#19
Franziska Würfel, Ramona Erber, Hanna Huebner, Alexander Hein, Michael P Lux, Sebastian Jud, Anita Kremer, Hannah Kranich, Andreas Mackensen, Lothar Häberle, Carolin C Hack, Claudia Rauh, Marius Wunderle, Paul Gaß, Shahrooz Rabizadeh, Anna-Lisa Brandl, Hanna Langemann, Bernhard Volz, Naiba Nabieva, Rüdiger Schulz-Wendtland, Diana Dudziak, Matthias W Beckmann, Arndt Hartmann, Peter A Fasching, Matthias Rübner
Background: Despite advancements in the treatment of primary and metastatic breast cancer, many patients lack a durable response to these treatments. Patients with triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2(HER2)-positive breast cancer who do not have a pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) have a very poor prognosis. Tumor-infiltrating lymphocytes (TILs) have been identified as a predictive marker for pCR after NACT in TNBC and HER2-positive breast cancer...
March 2018: Breast Care
https://www.readbyqxmd.com/read/29950960/immunotherapy-of-breast-cancer
#20
EDITORIAL
Barbara Seliger
No abstract text is available yet for this article.
March 2018: Breast Care
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