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Therapeutics and Clinical Risk Management

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https://www.readbyqxmd.com/read/27881923/predictive-value-of-serum-uric-acid-in-hospitalized-adolescents-and-adults-with-acute-asthma
#1
Nasser Keshar Abdulnaby, Ashraf Othman Sayed, Nehad Mohamed Shalaby
BACKGROUND: High serum uric acid (sUA) is an indicator of oxidative stress and is linked to tissue hypoxia in asthma. The objective of this case series was to investigate the prognostic role of sUA in patients with acute asthma exacerbations and the link between sUA and spirometric lung tests. PATIENTS AND METHODS: This cross-sectional observational study included 120 patients with acute asthma exacerbations and 120 controls, categorized according to peak expiratory flow rate into moderate, and severe and life-threatening asthma...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27881922/effectiveness-of-etofenamate-for-treatment-of-knee-osteoarthritis-a-randomized-controlled-trial
#2
Savaş Güner, Mehmet Ata Gökalp, Abdurrahim Gözen, Seyyid Şerif Ünsal, Şükriye İlkay Güner
The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis. The patients were randomly divided into etofenamate (n=29) and HA (n=30) groups. Intramuscular etofenamate injection was administered as a series of seven intramuscular injections at intervals of 1 day...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27877048/utilization-of-gastroprotective-strategies-for-nonsteroidal-anti-inflammatory-drug-induced-gastrointestinal-events-in-a-major-teaching-hospital
#3
Hooi Leng Lee, Siew Siang Chua, Sanjiv Mahadeva
BACKGROUND AND PURPOSE: Clinical guidelines recommend the prescribing of gastroprotective strategies in nonsteroidal anti-inflammatory drug (NSAID) users with risk factors for gastrointestinal (GI) ulcer or ulcer complications. However, these guidelines are not often translated into clinical practice. Therefore, the aim of this study was to investigate the utilization of gastroprotective strategies for NSAID-induced upper GI events in at-risk users in a major teaching hospital. PATIENTS AND METHODS: A cross-sectional, observational, pharmacy-based study was conducted in a major Asian institution with both primary and secondary health care services...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27877047/antiallergic-effect-of-the-atomized-extract-of-rhizome-of-curcuma-longa-flowers-of-cordia-lutea-and-leaves-of-annona-muricata
#4
Jorge Arroyo-Acevedo, Cesar Franco-Quino, Eliberto Ruiz-Ramirez, Roberto Chávez-Asmat, Andrea Anampa-Guzmán, Ernesto Raéz-González, José Cabanillas-Coral
INTRODUCTION: Allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. However, these drugs have many adverse effects. The use of medicinal plants could be an option, but they need to be evaluated. OBJECTIVE: This study was designed to evaluate the antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea, and leaves of Annona muricata. MATERIALS AND METHODS: Twenty-four New Zealand white albino rabbits were randomized into 2 groups...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27877046/comparative-effect-and-safety-of-verapamil-in-keloid-and-hypertrophic-scar-treatment-a-meta-analysis
#5
Zhouna Li, Zhehu Jin
BACKGROUND: Keloids and hypertrophic scars are the most common types of pathological scarring. Traditionally, keloids have been considered as a result of aberrant wound healing, involving excessive fibroblast participation that is characterized by hyalinized collagen bundles. However, the usefulness of this characterization has been questioned. In recent years, studies have reported the appropriate use of verapamil for keloids and hypertrophic scars. METHODS: Searches were conducted on the databases Medline, Embase, Cochrane, PubMed, and China National Knowledge Infrastructure from 2006 to July 2016...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27853374/management-of-extrapulmonary-sarcoidosis-challenges-and-solutions
#6
REVIEW
Khalid Al-Kofahi, Peter Korsten, Christian Ascoli, Shanti Virupannavar, Mehdi Mirsaeidi, Ian Chang, Naim Qaqish, Lesley A Saketkoo, Robert P Baughman, Nadera J Sweiss
BACKGROUND: Sarcoidosis is a chronic multisystem disease of unknown etiology characterized by noncaseating granulomas that most often involves the lungs, but frequently has extrapulmonary manifestations, which might be difficult to treat in individual patients. OBJECTIVE: To review different disease manifestations, focusing on extrapulmonary organ systems, and to provide treatment options for refractory cases. MATERIALS AND METHODS: We performed a literature search using Medline and Google Scholar for individual or combined keywords of "sarcoidosis, extrapulmonary, treatment, kidney, neurosarcoidosis, cardiovascular, gastrointestinal, transplantation, musculoskeletal, rheumatology, arthritis, and skin"...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27853373/shear-wave-elastography-imaging-for-assessing-the-chronic-pathologic-changes-in-advanced-diabetic-kidney-disease
#7
Kamal Hassan, Norman Loberant, Nur Abbas, Hassan Fadi, Hassan Shadia, Khaled Khazim
OBJECTIVE: The assessment of the grade of renal fibrosis in diabetic kidney disease (DKD) requires renal biopsy, which may be associated with certain risks. To assess the severity of chronic pathologic changes in DKD, we performed a quantitative analysis of renal parenchymal stiffness in advanced DKD, using shear wave elastography (SWE) imaging. PATIENTS AND METHODS: Twenty-nine diabetic patients with chronic kidney disease (CKD) grades 3-4 due to DKD, and 23 healthy subjects were enrolled...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27843323/patent-ductus-arteriosus-with-persistent-pulmonary-artery-hypertension-after-transcatheter-closure
#8
Jianqi Feng, Xiangqing Kong, Yanhui Sheng, Rong Yang
OBJECTIVES: To observe the change in pulmonary artery systolic pressure (PASP) of patients with persistent pulmonary arterial hypertension (PAH) after patent ductus arteriosus (PDA) occlusion. BACKGROUND: After occlusion of PDA in patients with PAH, some patients still tend to suffer from persistent PAH. METHODS: A chest X-ray, an electrocardiogram, and an echocardiogram were performed on nine patients at 24 hours, 1 and 6 months, and 1 year serially...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27822053/laparoscopic-total-extraperitoneal-repair-under-spinal-anesthesia-versus-general-anesthesia-a-randomized-prospective-study
#9
Turgut Donmez, Vuslat Muslu Erdem, Oguzhan Sunamak, Duygu Ayfer Erdem, Huseyin Imam Avaroglu
BACKGROUND: Laparoscopic total extraperitoneal (TEP) inguinal hernia repair is a well-known approach to inguinal hernia repair that is usually performed under general anesthesia (GA). To date, no reports compare the efficacy of spinal anesthesia (SA) with that of GA for laparoscopic hernia repairs. The purpose of this study was to compare the surgical outcome of TEP inguinal hernia repair performed when the patient was treated under SA with that performed under GA. MATERIALS AND METHODS: Between July 2015 and July 2016, 50 patients were prospectively randomized to either the GA TEP group (Group I) or the SA TEP group (Group II)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27822052/costs-of-inguinal-hernia-repair-associated-with-using-different-medical-devices-in-the-czech-republic
#10
Petra Marešová, Matus Peteja, Milan Lerch, Pavel Zonca, Kamil Kuca
OBJECTIVE: Inguinal hernia repair is one of the most frequently carried out operations worldwide. The purpose of this article is to analyze the costs of hernia repair and to specify the loss or profit made under the conditions in the Czech Republic with respect to the currently used medical devices and approaches. METHODS: This article is based on the Drummond and O'Brien methodology, which specifically determines the content of direct and indirect costs in health services...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27799780/secukinumab-for-ankylosing-spondylitis-and-psoriatic-arthritis
#11
REVIEW
Ennio Lubrano, Fabio Massimo Perrotta
The treatment of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) positively changed since the introduction of anti-TNFα drugs. These treatments were shown to reduce the symptoms and signs of the diseases and improve the quality of life. However, a variable percentage of patients do not respond to anti-TNFα or can exhibit a loss of response and, furthermore, despite anti-TNFα drugs' proven efficacy in reducing peripheral radiographic progression in PsA, the impact in reducing radiographic damage in AS is still debated...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27799779/therapy-of-psoriasis-with-narrowband-ultraviolet-b-light-influences-plasma-concentrations-of-mmp-2-and-timp-2-in-patients
#12
Edyta Katarzyna Głażewska, Marek Niczyporuk, Sławomir Ławicki, Maciej Szmitkowski, Monika Zajkowska, Grażyna Ewa Będkowska, Andrzej Przylipiak
BACKGROUND: Matrix metalloproteinases (MMPs), which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs), which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before and after the course of narrowband ultraviolet-B (NBUVB) therapy with respect to disease advancement...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27799778/the-potential-role-for-use-of-mitochondrial-dna-copy-number-as-predictive-biomarker-in-presbycusis
#13
Masoumeh Falah, Massoud Houshmand, Mohammad Najafi, Maryam Balali, Saeid Mahmoudian, Alimohamad Asghari, Hessamaldin Emamdjomeh, Mohammad Farhadi
OBJECTIVES: Age-related hearing impairment, or presbycusis, is the most common communication disorder and neurodegenerative disease in the elderly. Its prevalence is expected to increase, due to the trend of growth of the elderly population. The current diagnostic test for detection of presbycusis is implemented after there has been a change in hearing sensitivity. Identification of a pre-diagnostic biomarker would raise the possibility of preserving hearing sensitivity before damage occurs...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27799777/high-frequency-oscillatory-ventilation-is-an-effective-treatment-for-severe-pediatric-acute-respiratory-distress-syndrome-with-refractory-hypoxemia
#14
Yu-Xiong Guo, Zhao-Ni Wang, Ya-Ting Li, Li Pan, Li-Fen Yang, Yan Hu, Yue-Yu Sun, Liang-Ming Cai, Zhuang-Gui Chen
BACKGROUND AND PURPOSE: Early or primary application of high-frequency oscillatory ventilation (HFOV) has been recently suggested not to offer benefit to patients with acute respiratory distress syndrome (ARDS). However, the rescue effects of HFOV on severe pediatric acute respiratory distress syndrome (PARDS) with hypoxemia refractory to conventional mechanical ventilation (CMV) remain unclear. This study aimed to determine whether severe PARDS children would benefit from HFOV when oxygenation deteriorated on CMV and to identify any potential risk factors related to mortality...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27789954/use-of-ics-laba-extra-fine-and-non-extra-fine-in-elderly-asthmatics
#15
REVIEW
Alida Benfante, Marco Basile, Salvatore Battaglia, Mario Spatafora, Nicola Scichilone
Age represents an exclusion criterion in randomized clinical trials designed to test the efficacy and safety of inhaled drugs in asthma. As a consequence, data on efficacy and safety of inhaled corticosteroid (ICS) and long-acting β2 agonist (LABA) combinations in elderly asthmatics are scanty. Older age is associated with an increased proportion of comorbid conditions; in addition, all organ functions undergo a process of senescence, thus reducing their ability to metabolize the agents. Overall, these age-associated conditions may variably, and often unpredictably, affect the metabolism and excretion of respiratory drugs...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27785042/comparison-of-classical-diagnostic-criteria-and-chinese-revised-diagnostic-criteria-for-fever-of-unknown-origin-in-chinese-patients
#16
Jia-Jun Li, Wen-Xiang Huang, Zheng-Yu Shi, Qiu Sun, Xiao-Juan Xin, Jin-Qiu Zhao, Zhen Yin
BACKGROUND: Fever of unknown origin (FUO) has always been a challenging problem for physicians since it was first reported half a century ago. This study aimed to investigate the clinical features of FUO and to compare the clinical significance of the classical diagnostic criteria and the Chinese revised diagnostic criteria of FUO. METHODS: We retrospectively collected a series of 140 patients admitted to our hospital between September 2011 and June 2013 because of prolonged febrile illnesses (lasting at least 2 weeks, temperature ≥38...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27785041/impact-of-statins-on-risk-of-new-onset-diabetes-mellitus-a-population-based-cohort-study-using-the-korean-national-health-insurance-claims-database
#17
Jimin Lee, Yoojin Noh, Sooyoung Shin, Hong-Seok Lim, Rae Woong Park, Soo Kyung Bae, Euichaul Oh, Grace Juyun Kim, Ju Han Kim, Sukhyang Lee
Statin therapy is beneficial in reducing cardiovascular events and mortalities in patients with atherosclerotic cardiovascular diseases. Yet, there have been concerns of increased risk of diabetes with statin use. This study was aimed to evaluate the association between statins and new onset diabetes mellitus (NODM) in patients with ischemic heart disease (IHD) utilizing the Korean Health Insurance Review and Assessment Service claims database. Among adult patients with preexisting IHD, new statin users and matched nonstatin users were identified on a 1:1 ratio using proportionate stratified random sampling by sex and age...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27785040/mathematical-evaluation-of-the-influence-of-multiple-factors-on-implant-stability-quotient-values-in-clinical-practice-a-retrospective-study
#18
Hairong Huang, Daniel Wismeijer, Xianhong Shao, Gang Wu
OBJECTIVES: The objective of this study is to mathematically evaluate the influence of multiple factors on implant stability quotient values in clinical practice. PATIENTS AND METHODS: Resonance frequency analysis was performed at T1 (measured immediately at the time of implant placement) and at T2 (measured before dental restoration) in 177 patients (329 implants). Using a multivariate linear regression model, we analyzed the influence of the following eleven candidate factors: sex, age, maxillary/mandibular location, bone type, immediate/delayed implantation, bone grafting (presence or absence), insertion torque, I-/II-stage healing pattern, implant diameter, implant length, and T1-T2 time interval...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27785039/inappropriateness-of-medication-prescriptions-about-chronic-kidney-disease-patients-without-dialysis-therapy-in-a-chinese-tertiary-teaching-hospital
#19
Ping Yang, Na Chen, Rong-Rong Wang, Lu Li, Sai-Ping Jiang
BACKGROUND: With the increasing incidence rate of chronic kidney disease (CKD), inappropriate use of medicine in CKD patients is an important issue, as it may cause adverse effects in patients and progression to chronic renal failure. OBJECTIVE: The aim of this study is to assess the frequency of inappropriate medicine use among CKD patients. METHODS: A cross-sectional study was conducted from November 1 to December 1, 2014 in a Chinese teaching tertiary hospital...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27785038/association-of-medications-for-lifestyle-related-diseases-with-reflux-esophagitis
#20
Daisuke Asaoka, Akihito Nagahara, Mariko Hojo, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Kentaro Izumi, Tsutomu Takeda, Hiroyuki Komori, Yoichi Akazawa, Yuji Shimada, Taro Osada, Sumio Watanabe
BACKGROUND: Because of a change in lifestyle, especially adoption of westernized eating habits, lifestyle-related diseases have become increasingly prevalent. The aim of this study was to investigate the association of medications for lifestyle-related diseases with reflux esophagitis (RE). METHODS: We conducted a hospital-based, cross-sectional retrospective study of consecutive outpatients who received an upper gastrointestinal endoscopy in our department from February 2008 to November 2014, which was performed by one specialist who was a member of the Japan Gastroenterological Endoscopy Society...
2016: Therapeutics and Clinical Risk Management
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