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Therapeutics and Clinical Risk Management

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[This corrects the article on p. 741 in vol. 14, PMID: 29719401.].
2018: Therapeutics and Clinical Risk Management
Yuichi Ishikawa, Tadamichi Kasuya, Junichi Ishikawa, Michio Fujiwara, Yasuhiko Kita
Progressive multifocal leukoencephalopathy (PML) is a central nervous system infection caused by John Cunningham (JC) virus reactivation in an immunocompromised patient. PML has various neurologic symptoms and has very poor prognosis. A 36-year-old man developed transverse myelitis and had a psychiatric disorder at the age of 26. He was diagnosed with systemic lupus erythematosus (SLE) and neuropsychiatric SLE (NPSLE), on the basis of leukopenia and presence of anti-DNA and anti-nuclear antibodies. Treatment with glucocorticoid (GC) was started, and remission was introduced...
2018: Therapeutics and Clinical Risk Management
Bin-Bin Jin, Yi-Zhen Gong, Yan Ma, Zhong-Hui He
Background: Ultrasonography, the preferred adjunct examination method and the differential diagnostic tool for gynecologic emergency, can reflect the change pattern of gynecological diseases in daytime and at night. The purpose of this study was to analyze the diseases through gynecological emergency ultrasound in daytime and at night and to evaluate the day-night difference in the accuracy of ultrasound diagnosis. Materials and methods: Retrospective analysis was performed on the 2016 clinical data of the patients who had undergone gynecological emergency ultrasound at The First Affiliated Hospital of Guangxi Medical University, and the results of the ultrasound diagnosis were compared with the clinical diagnosis...
2018: Therapeutics and Clinical Risk Management
Yong Xiang, Yi-Yi Xuan, Guangheng Li
Methicillin-resistant Staphylococcus aureus (MRSA) and Candidal prosthetic joint infections (PJIs) are very rare, and the optimal management for these patients is still unknown. A 54-year-old man with traumatic arthritis due to previous electric injury successfully retained the implant despite the successive infection with MRSA and Candida albicans after total knee arthroplasty (TKA). Continuous lavage with vancomycin was used to control MRSA infection and repeated local washout plus oral swallow with voriconazole tablet were administered to eradicate C...
2018: Therapeutics and Clinical Risk Management
Hongfang Zhao, Siyu Tian, Lingde Kong, Jiangbo Bai, Jian Lu, Bing Zhang, Dehu Tian
Background: The aim of this study was to investigate the union time of acute middle-third scaphoid fractures following treatments and to analyze the effect of different factors on late union. Patients and methods: We retrospectively reviewed patients with acute middle-third scaphoid fracture at our institution between January 2013 and December 2017. Patient demographics, fracture characteristics, and treatment strategy, such as age, gender, body mass index, habit of smoking, sides of injury, dominant hand, ulnar variance, multiple fractures, and treatment methods, were investigated...
2018: Therapeutics and Clinical Risk Management
Yee Wei Shim, Siew Siang Chua, Hui Chin Wong, Syireen Alwi
Background: The elderly population is the largest consumer of medications as this age group is at high risk for developing chronic diseases. However, medication use among elderly people is complicated by an increased risk of drug-related problems. Therefore, the present study was conducted to investigate the effects of collaborative interventions between pharmacists and physicians on health-related outcomes of elderly patients. Patients and methods: This was a randomized controlled trial (RCT) conducted on elderly outpatients who sought treatment in the Medical Outpatient Department of a public tertiary hospital in Malaysia and who were taking at least five medications...
2018: Therapeutics and Clinical Risk Management
Jing Huang, Dan Zhang, Shu-Jing Li, Ying Xi, Li-Yan Cui, Feng-Li Gao
Objective: Prolonged maintenance of surgical position often results in postoperative pain and discomfort in patients. The present study aimed to investigate the effect of preoperative practice of surgical position on postoperative pain and general comfort in patients receiving kidney surgeries. Methods: For this nonrandomized pilot study, 74 patients receiving kidney surgeries were selected using the probability sampling method. Patients from ward 1 were assigned to the practice group (n=35), and those from ward 2 were assigned to the control group (n=39)...
2018: Therapeutics and Clinical Risk Management
Yung-Fong Tsai, Fu-Chao Liu, Chang-Fu Kuo, Ting-Ting Chung, Huang-Ping Yu
Background: Immunosuppression plays an essential role to overcome immune-related allograft rejection, but it also causes some nephrotoxicity. This study aimed to investigate how the immunosuppressant combinations affect graft outcomes in kidney transplant recipients. Methods: A nationwide population-based cohort study using the Taiwan National Health Insurance Database was conducted. A total of 3,441 kidney transplant recipients who underwent kidney transplantation during the targeted period were included...
2018: Therapeutics and Clinical Risk Management
Dongmiao Chen, Yajie Zhang, Yinjuan Xu, Tingting Shen, Guorui Cheng, Bingkang Huang, Xiandong Ruan, Congrong Wang
Objective: This study aimed to compare the performance of chemiluminescence immunoassay (CLIA), enzyme-linked immunosorbent assay (ELISA), and passive agglutination (PA) method in detecting Mycoplasma pneumoniae (MP) infection. Methods: This study enrolled a total of 280 patients who were consecutively seen at the Nanfang Hospital of the Southern Medical University in Guangdong Province, China, between August and December 2016. Serum was collected and examined by CLIA, ELISA, and PA, respectively...
2018: Therapeutics and Clinical Risk Management
Qin Tong, Shuming Ouyang, Lingling Feng, Hanyu Wang, Yunfei Xia, Yujing Zhang
Background: This study aims to retrospectively analyze the salvage treatment outcomes and prognostic factors of patients with early stage locoregionally recurrent (LRR) extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL). Methods: Between January 1995 and December 2014, 540 patients with stage IE-IIE ENKTCL received chemotherapy (ChT) and/or radiotherapy (RT) in our hospital, and among these, 56 patients who experienced LRR were included in this study...
2018: Therapeutics and Clinical Risk Management
Yufang Gao, Yuxiu Liu, Hui Zhang, Fang Fang, Lei Song
Background: Tip position verification of peripherally inserted central catheters (PICCs) is essential to the use of the catheter. Postprocedural chest X-ray as the "gold standard" practice for PICC tip confirmation can lead to a significant delay for patient IV therapy, cost more, and lead to radiation exposure for both patients and staffs. Intracavitary electrocardiogram (IC-ECG)-guided PICC placement which provides real-time tip confirmation during the insertion procedure has been widely used...
2018: Therapeutics and Clinical Risk Management
Onur Argan, Dilek Ural, Kurtuluş Karauzum, Serdar Bozyel, Mujdat Aktas, Irem Yilmaz Karauzum, Güliz Kozdag, Aysen Agacdiken Agir
Background: Elevated vitamin B12 is a sign for liver damage, but its significance in chronic stable heart failure (HF) is less known. The present study investigated the clinical correlates and prognostic significance of vitamin B12 levels in stable systolic HF. Methods: A total of 129 consecutive patients with HF and 50 control subjects were enrolled. Data regarding demographics, clinical signs, therapeutic and conventional echocardiographic measurements were recorded for all patients...
2018: Therapeutics and Clinical Risk Management
Yoon Hae Kwak, Jae-Hyun Kim, Young-Chang Kim, Kun-Bo Park
Background and purpose: Closed reduction and lateral-only pin fixation is one of the common treatment methods for displaced supracondylar fracture in children. However, several risk factors related to the stability have been reported. The aim of this study was to evaluate the medial comminution as a potential risk factor related to the stability after appropriate lateral-only pin fixation for Gartland type III supracondylar humerus fracture. Methods: Sixty-seven patients with type III supracondylar fractures who were under the age of 12 years were included...
2018: Therapeutics and Clinical Risk Management
Francesco Ursini, Emilio Russo, Roberto De Giorgio, Giovambattista De Sarro, Salvatore D'Angelo
Psoriatic arthritis (PsA) is a chronic inflammatory disease of joints, tendon sheaths, and entheses affecting patients with established skin psoriasis, or, less frequently, patients without a personal history of psoriasis with a positive familial history. Many treatment options are now available to deal with the different aspects of the disease, including traditional and biological disease-modifying antirheumatic drugs and the recently released targeted synthetic disease-modifying antirheumatic drugs. However, ~40% of patients still fail to achieve a meaningful clinical response to first-line biologic therapy advocating the development of novel medications...
2018: Therapeutics and Clinical Risk Management
Jeanne-Marie Perotin, Claire Launois, Maxime Dewolf, Antoine Dumazet, Sandra Dury, François Lebargy, Valérian Dormoy, Gaëtan Deslee
Chronic cough is a common complaint and a frequent cause of medical consultation. Its management can be difficult. We present here an overview of the current guidelines for the management of chronic cough. Different steps are detailed, including the initial research of an obvious etiology and alert signs that should lead to further investigation of underlying condition. The diagnosis of the most frequent causes: asthma, non-asthmatic eosinophilic bronchitis, gastroesophageal reflux disease and upper airway cough syndrome should be considered, assessed and treated accordingly...
2018: Therapeutics and Clinical Risk Management
Michael D Jain, Christina A Bachmeier, Vania H Phuoc, Julio C Chavez
Adoptive T-cell immunotherapy is a rapidly growing field and is shifting the paradigm of clinical cancer treatment. Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor T-cell therapy that was initially developed at the National Cancer Institute and has recently been commercially approved by the US Food and Drug Administration for relapsed or refractory aggressive non-Hodgkin's lymphomas including diffuse large B-cell lymphoma and its variants. The ZUMA-1 Phase I and II clinical trials formed the basis of the US Food and Drug Administration approval of this product, and we discuss the particulars of the clinical trials and the pharmacology of axi-cel...
2018: Therapeutics and Clinical Risk Management
Dharmesh Gopalakrishnan, Vadim S Koshkin, Moshe C Ornstein, Athanasios Papatsoris, Petros Grivas
Bladder cancer is the sixth most common cancer in the US and most tumors have urothelial (transitional cell) histology. Platinum-based chemotherapy has long been the standard of care in advanced disease, but long-term outcomes have largely remained poor. Since the peak incidence of bladder cancer is in the eighth decade of life and beyond, medical comorbidities may often limit the use of chemotherapy. Immune checkpoint inhibitors with their favorable toxicity profiles and notable antitumor activity have ushered in a new era in the treatment of advanced urothelial cancer (UC) with five agents targeting the PD-1/PD-L1 pathway being recently approved by the US Food and Drug administration...
2018: Therapeutics and Clinical Risk Management
Jan Máca, Matúš Peteja, Petr Reimer, Ondřej Jor, Věra Šeděnková, Lucie Panáčková, Peter Ihnát, Michal Burda, Pavel Ševčík
Background: Major abdominal surgery (MAS) is high-risk intervention usually accompanied by tissue injury leading to a release of signaling danger molecules called alarmins. This study evaluates the surgical injury caused by two fundamental types of gastrointestinal surgical procedures (open surgery and laparoscopy) in relation to the inflammation elicited by alarmins. Patients and methods: Patients undergoing MAS were divided into a mixed laparoscopy group (LPS) and an open surgery group (LPT)...
2018: Therapeutics and Clinical Risk Management
Qing Li, Tao Wu, Xiao-An Ma, Li Jing, Li-Li Han, Hui Guo
Background: The association of ABO blood group with prognosis of several malignancies has been established. However, its role in hepatocellular carcinoma (HCC) remains unclear. Patients and methods: In this study, we investigated the prognostic role of ABO blood group in unresectable HCC patients receiving transarterial chemoembolization (TACE) as an initial treatment. Medical records of 2,611 HCC patients were collected, and clinical data of 282 unresectable HCC patients receiving TACE were ultimately analyzed retrospectively...
2018: Therapeutics and Clinical Risk Management
Wandong Hong, Vincent Zimmer, Simon Stock, Maddalena Zippi, Jones Aq Omoshoro-Jones, Mengtao Zhou
Background and aim: The aim of this study was to investigate the association between low-density lipoprotein cholesterol (LDL-C) and the development of severe acute pancreatitis (SAP). Patients and methods: A total of 674 patients with acute pancreatitis were enrolled. Non-linearity in the relationship between LDL-C and SAP was assessed by restricted cubic spline analysis. Univariable and multivariable regression analyses were used to identify independent risk factors of SAP...
2018: Therapeutics and Clinical Risk Management
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