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Therapeutics and Clinical Risk Management

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https://www.readbyqxmd.com/read/28331333/the-risk-reduction-of-recurrent-periodontal-pathogens-of-local-application-minocycline-hcl-2-gel-used-as-an-adjunct-to-scaling-and-root-planing-for-chronic-periodontitis-treatment
#1
Y Soeroso, T Akase, H Sunarto, Y Kemal, R Salim, M Octavia, A Viandita, J Setiawan, B M Bachtiar
BACKGROUND: The aim of this study was to evaluate the clinical and microbiological effects of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis (CP). CP is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred. METHODS: A total of 81 subjects with moderate to severe periodontitis whose baseline clinical attachment loss (CAL) was ≥4 mm were randomly assigned to receive SRP alone (control group, N=39) or SRP followed by four times of local application of minocycline HCl gel (Periocline) once a week (test group, N=42)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28331332/clinical-role-of-brexpiprazole-in-depression-and-schizophrenia
#2
REVIEW
Nishant B Parikh, Diana M Robinson, Anita H Clayton
Brexpiprazole, a serotonin-dopamine activity modulator, is the second D2 partial agonist to come to market and has been approved for the treatment of schizophrenia and as an adjunctive treatment in major depressive disorder. With less intrinsic activity than aripiprazole at the D2 receptor and higher potency at 5-HT2A, 5-HT1A, and α1B receptors, the pharmacological properties of brexpiprazole suggest a more tolerable side effect profile with regard to akathisia, extrapyramidal dysfunction, and sedation. While no head-to-head data are currently available, double-blind placebo-controlled studies show favorable results, with the number needed to treat (NNT) vs placebo of 6-15 for response in acute schizophrenia treatment and 4 for maintenance...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28331331/the-influence-of-surgical-technique-on-early-posttransplant-atrial-fibrillation-comparison-of-biatrial-bicaval-and-total-orthotopic-heart-transplantation
#3
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Christian Erbel, Christian A Gleissner, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Hugo A Katus, Andreas O Doesch
PURPOSE: Early posttransplant atrial fibrillation (AF) has been associated with worse clinical outcomes after heart transplantation (HTX). The type of surgical technique may constitute a relevant risk factor for AF. PATIENTS AND METHODS: This retrospective single-center study included 530 adult patients. Patients were stratified by surgical technique (biatrial, bicaval, or total orthotopic HTX) and early posttransplant heart rhythm (AF or sinus rhythm). Univariate and multivariate analyses were performed to evaluate risk factors for AF...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28280347/high-expression-of-aldolase-a-predicts-poor-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#4
Ning Na, Heng Li, Chengfang Xu, Bin Miao, Liangqing Hong, Zhengyu Huang, Qiu Jiang
BACKGROUND: Aldolase A (ALDOA) is a glycolytic enzyme that drives the glycolytic metabolic pathway in mammalian cells. The overexpression of ALDOA was observed in a variety of cancers including clear-cell renal cell carcinoma (ccRCC). However, little was known about the clinicopathological significance and prognostic value of ALDOA in ccRCC patients. METHODS: The expression of ALDOA was detected using immunohistochemical staining in 162 formalin-fixed, paraffin-embedded ccRCC sections...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260914/helicobacter-pylori-infection-is-not-associated-with-failure-to-thrive-a-case-control-study
#5
Nan-Chang Chiu, Chien-Yu Lin, Hsin Chi, Chun-Yan Yeung, Wei-Hsin Ting, Wai-Tao Chan, Chuen-Bin Jiang, Sung-Tse Li, Chao-Hsu Lin, Hung-Chang Lee
PURPOSE: The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate the association between H. pylori infection and failure to thrive (FTT). PATIENTS AND METHODS: From January 2009 to December 2011, 53 children with FTT group and matched children with the same sex and age and similar socioeconomic status without FTT (control group) were enrolled. A questionnaire was administered to the parents/guardian, and a (13)C-urea breath test was performed to detect H...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260913/music-therapy-induced-changes-in-salivary-cortisol-level-are-predictive-of-cardiovascular-mortality-in-patients-under-maintenance-hemodialysis
#6
Yi-Chou Hou, Yen-Ju Lin, Kuo-Cheng Lu, Han-Sun Chiang, Chia-Chi Chang, Li-King Yang
BACKGROUND: Music therapy has been applied in hemodialysis (HD) patients for relieving mental stress. Whether the stress-relieving effect by music therapy is predictive of clinical outcome in HD patients is still unclear. METHODS: We recruited a convenience sample of 99 patients on maintenance HD and randomly assigned them to the experimental (n=49) or control (n=50) group. The experimental group received relaxing music therapy for 1 week, whereas the control group received no music therapy...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260912/association-of-uremic-pruritus-in-hemodialysis-patients-with-the-number-of-days-of-high-mean-24-hour-particulate-matter-with-a-diameter-of-2-5-%C3%AE-m
#7
Ming-Hui Liu, Ming-Jen Chan, Ching-Wei Hsu, Cheng-Hao Weng, Tzung-Hai Yen, Wen-Hung Huang
Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 μm [PM10] and PM with a diameter of <2.5 μm [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260911/increased-risk-of-endotracheal-intubation-and-heart-failure-following-acute-myocardial-infarction-in-patients-with-urolithiasis-a-nationwide-population-based-study
#8
Shun-Ku Lin, Jui-Ming Liu, Ying-Hsu Chang, Yuan-Tien Ting, See-Tong Pang, Ren-Jun Hsu, Po-Hung Lin
BACKGROUND: Urolithiasis is a common urinary tract disease worldwide. It has been connected to systemic diseases, including hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular disease. In the current study, we aimed to evaluate the relationship between urolithiasis and the complications of acute myocardial infarction (AMI). MATERIALS AND METHODS: Data were obtained from the Longitudinal Health Insurance Database 2005 of the National Health Insurance Research Database...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260910/psychological-factors-as-risk-factors-for-poor-hip-function-after-total-hip-arthroplasty
#9
Achim Benditz, Petra Jansen, Jan Schaible, Christina Roll, Joachim Grifka, Jürgen Götz
Recovery after total hip arthroplasty (THA) is influenced by several psychological aspects, such as depression, anxiety, resilience, and personality traits. We hypothesized that preoperative depression impedes early functional outcome after THA (primary outcome measure). Additional objectives were perioperative changes in the psychological status and their influence on perioperative outcome. This observational study analyzed depression, anxiety, resilience, and personality traits in 50 patients after primary unilateral THA...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260909/update-on-targeted-therapies-for-advanced-non-small-cell-lung-cancer-nivolumab-in-context
#10
REVIEW
Alexander D Le, Saeed K Alzghari, Gary W Jean, Ninh M La-Beck
While the initial treatment of non-small cell lung cancer (NSCLC) usually relies on surgical resection followed by systemic cytotoxic chemotherapy and/or radiation therapy, recent advances in understanding of NSCLC biology and immunology have spurred the development of numerous targeted therapies. In particular, a class of immune modulatory drugs targeting the immune checkpoint pathways has demonstrated remarkable durable remissions in a select minority of advanced NSCLC patients, potentially heralding the elusive "cancer cure"...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260908/statin-therapy-reduces-the-likelihood-of-suboptimal-blood-pressure-control-among-ugandan-adult-diabetic-patients
#11
William Lumu, Leaticia Kampiire, George Patrick Akabwai, Daniel Ssekikubo Kiggundu, Davis Kibirige
BACKGROUND: Hypertension is one of the recognized risk factors of cardiovascular diseases in adult diabetic patients. High prevalence of suboptimal blood pressure (BP) control has been well documented in the majority of studies assessing BP control in diabetic patients in sub-Saharan Africa. In Uganda, there is a dearth of similar studies. This study evaluated the prevalence and correlates of suboptimal BP control in an adult diabetic population in Uganda. PATIENTS AND METHODS: This was a cross-sectional study that enrolled 425 eligible ambulatory adult diabetic patients attending three urban diabetic outpatient clinics over 11 months...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260907/effect-of-orlistat-on-periostin-adiponectin-inflammatory-markers-and-ultrasound-grades-of-fatty-liver-in-obese-nafld-patients
#12
Rashid Ali Khan, Prem Kapur, Abhinav Jain, Farrukh Farah, Uma Bhandari
Orlistat is recommended in the treatment of obesity, which is an independent risk factor for nonalcoholic fatty liver disease (NAFLD). The reported findings of orlistat in NAFLD are divisive. Recently, periostin is identified as an important regulatory molecule in the pathogenesis of obesity-induced fatty liver. Therefore, this study aimed to evaluate the potential effects of orlistat in the treatment of NAFLD. A 16-week prospective observational study was conducted, with obese NAFLD patient (n=77) receiving orlistat (120 mg capsules, three times a day) with hypocaloric diet or hypocaloric diet only...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28255240/evaluation-of-external-pressure-to-the-sacral-region-in-the-lithotomy-position-using-the-noninvasive-pressure-distribution-measurement-system
#13
Ju Mizuno, Toru Takahashi
BACKGROUND: Pressure ulcers (PUs) in the sacral region can be a complication of surgical procedures performed in the lithotomy position. Previous reports have noted a difference between men and women in PU development related to the supine position, and body weight and body mass index (BMI) have been also described as known risk factors in supine position-related PU development. The BIG-MAT(®) system is a noninvasive pressure distribution measurement device used to measure external pressure (EP)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243110/in-vivo-efficacy-of-artemether-lumefantrine-against-uncomplicated-plasmodium-falciparum-malaria-in-dembia-district-northwest-ethiopia
#14
Tekalign Deressa, Mengistu Endris Seid, Wubet Birhan, Yetemwork Aleka, Biniam Mathewos Tebeje
BACKGROUND: Artemether-lumefantrine (AL) has been used as a first-line treatment for uncomplicated Plasmodium falciparum malaria in Ethiopia since 2004. Antimalarial drug resistance is one of the major obstacles for malaria control and curtails the lifespan of several drugs. Thus, continued monitoring of the efficacy of AL is of great public health importance in malaria endemic areas. OBJECTIVE: This study aimed to investigate the therapeutic efficacy and safety of AL for the treatment of uncomplicated P...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243109/prognostic-value-of-increased-expression-of-raco-1-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma
#15
Jian-Yao Chen, Li-Ping Liu, Jiang-Feng Xu
RING domain AP-1 coactivator-1 (RACO-1) is a coactivator that links c-Jun to growth factor signaling and is essential for AP-1 function. This study aimed to investigate the expression and clinical significance of RACO-1 protein in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in China. A total of 136 tissue samples of HBV-related HCC were detected by immunohistochemistry (including 76 patients in training cohort and 60 patients in validation cohort). Correlation between RACO-1 expression and clinicopathologic features of HBV-related HCC was analyzed in both the cohorts...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243108/successful-peroral-endoscopic-myotomy-performed-in-endoscopy-department-as-a-radical-long-term-treatment-for-esophageal-achalasia-the-greek-experience
#16
Nikolas Eleftheriadis, Eleni Damianos Eleftheriadou
INTRODUCTION: Peroral endoscopic myotomy (POEM) has been considered as a minimal-invasive, innovative technique for long-term treatment of all types of esophageal achalasia and other esophageal motility disorders. PATIENTS AND METHODS: We report on 20 consecutive Greek patients with manometrically proved esophageal achalasia (14 patients with type I, 4 with type II, 2 with type III, and 4 with sigmoid esophagus), with an age range of 32-92 years, mean age 59 years, 12 males, successfully treated by POEM from 2013 to 2015...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243107/intermittent-pneumatic-compression-devices-combined-with-anticoagulants-for-prevention-of-symptomatic-deep-vein-thrombosis-after-total-knee-arthroplasty-a-pilot-study
#17
Pengcheng Liu, Junfeng Liu, Liyang Chen, Kuo Xia, Xing Wu
OBJECTIVES: To investigate the effectiveness of intermittent pneumatic compression (IPC) devices combined with anticoagulants for the prevention of deep vein thrombosis (DVT) after total knee arthroplasty (TKA). PATIENTS AND METHODS: In total 120 patients were involved in this pilot study. Patients in the control group received 10 mg of rivaroxaban per day after surgery. In addition to the prescription of rivaroxaban, IPC devices were used in the experimental group...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243106/ruxolitinib-in-myelofibrosis-to-be-or-not-to-be-an-immune-disruptor
#18
Palma Manduzio
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm classified according to the 2016 revision of World Health Organization Classification of Tumors and Haematopoietic and Lymphoid Tissue. Ruxolitinib is an oral inhibitor of Janus kinase approved in the USA for the treatment of intermediate or high-risk PMF and approved in Europe for the treatment of splenomegaly and constitutional symptoms of the disease. More recently, case reports described serious opportunistic infections in this neoplasm treated with ruxolitinib...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28243105/short-term-bisphosphonate-treatment-reduces-serum-25-oh-vitamin-d3-and-alters-values-of-parathyroid-hormone-pentosidine-and-bone-metabolic-markers
#19
Mikio Kamimura, Shigeharu Uchiyama, Yukio Nakamura, Shota Ikegami, Keijiro Mukaiyama, Hiroyuki Kato
This study aimed to clarify the effects of short-term bisphosphonate (BP) administration in Japanese osteoporotic patients retrospectively. Daily minodronate (MIN) at 1 mg/day (MIN group) or weekly risedronate (RIS) at 17.5 mg/week (RIS group) was primarily prescribed for each patient. We analyzed the laboratory data of 35 cases (18 of MIN and 17 of RIS) before the start of treatment and at 4 months afterward. The changes in 25(OH)D3, whole parathyroid hormone (PTH), serum pentosidine, and the bone turnover markers urinary cross-linked N-telopeptide of type I collagen (NTX), serum tartrate-resistant acid phosphatase (TRACP)-5b, bone-specific alkaline phosphatase (BAP), and undercarboxylated osteocalcin were evaluated...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28223817/emergency-thoracic-ultrasound-and-clinical-risk-management
#20
Maria Concetta Interrigi, Francesca M Trovato, Daniela Catalano, Guglielmo M Trovato
PURPOSE: Thoracic ultrasound (TUS) has been proposed as an easy-option replacement for chest X-ray (CXR) in emergency diagnosis of pneumonia, pleural effusion, and pneumothorax. We investigated CXR unforeseen diagnosis, subsequently investigated by TUS, considering its usefulness in clinical risk assessment and management and also assessing the sustainability of telementoring. PATIENTS AND METHODS: This observational report includes a period of 6 months with proactive concurrent adjunctive TUS diagnosis telementoring, which was done using freely available smartphone applications for transfer of images and movies...
2017: Therapeutics and Clinical Risk Management
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