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Therapeutics and Clinical Risk Management

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https://www.readbyqxmd.com/read/28223817/emergency-thoracic-ultrasound-and-clinical-risk-management
#1
Maria Concetta Interrigi, Francesca M Trovato, Daniela Catalano, Guglielmo M Trovato
PURPOSE: Thoracic ultrasound (TUS) has been proposed as an easy-option replacement for chest X-ray (CXR) in emergency diagnosis of pneumonia, pleural effusion, and pneumothorax. We investigated CXR unforeseen diagnosis, subsequently investigated by TUS, considering its usefulness in clinical risk assessment and management and also assessing the sustainability of telementoring. PATIENTS AND METHODS: This observational report includes a period of 6 months with proactive concurrent adjunctive TUS diagnosis telementoring, which was done using freely available smartphone applications for transfer of images and movies...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28223816/prevalence-of-metabolic-syndrome-in-adolescents-living-in-mthatha-south-africa
#2
Morongwe Annah Sekokotla, Nandu Goswami, Constance Rufaro Sewani-Rusike, Jehu Erapu Iputo, Benedicta Ngwenchi Nkeh-Chungag
OBJECTIVE: Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28223815/antitumor-effects-of-oncolytic-herpes-simplex-virus-type-2-against-colorectal-cancer-in-vitro-and-in-vivo
#3
Lei Yin, Chunhong Zhao, Jixia Han, Zengjun Li, Yanan Zhen, Ruixue Xiao, Zhongfa Xu, Yanlai Sun
BACKGROUND: The incidence of colorectal cancer (CRC) is on the rise. Furthermore, late-stage diagnoses and limited efficacious treatment options make CRC a complex clinical challenge. Therefore, a new therapeutic regimen with a completely novel therapeutic mechanism is necessary for CRC. In the present study, the therapeutic efficacy of oncolytic herpes simplex virus type 2 (oHSV2) in CRC was assessed in vitro and in vivo. oHSV2 is an oncolytic agent derived from herpes simplex virus type 2 that encodes granulocyte-macrophage colony-stimulating factor...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28182117/fibrin-sheaths-in-central-venous-port-catheters-treatment-with-low-dose-single-injection-of-urokinase-on-an-outpatient-basis
#4
De-Hua Chang, Kamal Mammadov, Tilman Hickethier, Jan Borggrefe, Martin Hellmich, David Maintz, Christoph Kabbasch
PURPOSE: Evaluation of the efficacy of single-shot, low-dose urokinase administration for the treatment of port catheter-associated fibrin sheaths. METHODS: Forty-six patients were retrospectively evaluated for 54 episodes of port catheter dysfunction. The presence of a fibrin sheath was detected by angiographic contrast examinations. On an outpatient basis, patients subsequently received thrombolysis consisting of a single injection of urokinase (15.000 IU in 1...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28176953/survival-status-and-predictors-of-mortality-among-severely-acute-malnourished-children-5-years-of-age-admitted-to-stabilization-centers-in-gedeo-zone-a-retrospective-cohort-study
#5
Tadele Girum, Mesfin Kote, Befikadu Tariku, Henok Bekele
Despite the existence of standard protocol, many stabilization centers (SCs) continue to experience high mortality of children receiving treatment for severe acute malnutrition. Assessing treatment outcomes and identifying predictors may help to overcome this problem. Therefore, a 30-month retrospective cohort study was conducted among 545 randomly selected medical records of children <5 years of age admitted to SCs in Gedeo Zone. Data was entered by Epi Info version 7 and analyzed by STATA version 11. Cox proportional hazards model was built by forward stepwise procedure and compared by the likelihood ratio test and Harrell's concordance, and fitness was checked by Cox-Snell residual plot...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28176911/effects-of-bariatric-surgery-on-urinary-incontinence
#6
Nurullah Bulbuller, Mani Habibi, Mustafa Yuksel, Onur Ozener, Mehmet Tahir Oruc, Osman Zekai Oner, Mehmet Altug Kazak
INTRODUCTION: Obesity is an important modifiable etiological factor associated with several diseases. There is strong evidence that urinary incontinence (UI) is positively correlated with body mass index (BMI). AIM: One of the many benefits experienced by obese patients after bariatric surgery is decrease in UI. To investigate this correlation, we aimed to examine the effects of weight loss on UI in female patients who had undergone laparoscopic sleeve gastrectomy (LSG)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28176906/comparison-of-outcomes-between-minimally-invasive-transforaminal-lumbar-interbody-fusion-and-traditional-posterior-lumbar-intervertebral-fusion-in-obese-patients-with-lumbar-disk-prolapse
#7
Ya-Peng Wang, Ji-Long An, Ya-Peng Sun, Wen-Yuan Ding, Yong Shen, Wei Zhang
OBJECTIVE: The aim of this study was to compare the curative effect between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and the posterior lumbar interbody fusion (PLIF) in obese patients with lumbar disk prolapse. PATIENTS AND METHODS: In this study, 72 patients who underwent lumbar disk prolapse therapy in the Third Hospital of Hebei Medical University between March 2011 and 2015 were retrospectively analyzed and were divided into two groups, MIS-TLIF group (n=35) and PLIF group (n=37), according to different surgical procedures...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28144149/can-achilles-tendon-be-used-as-a-new-distal-landmark-for-coronal-tibial-component-alignment-in-total-knee-replacement-surgery-an-observational-mri-study
#8
Uğur Tiftikçi, Sancar Serbest, Veysel Burulday
BACKGROUND: In total knee arthroplasty, it is better to use more than one reference point for correct alignment of the components. By measuring the distances of Achilles tendon (AT) and other conventional landmarks from the mechanical axis in magnetic resonance imaging (MRI) of the ankle, we aimed to demonstrate that, as a novel landmark which can help for correct alignment in the coronal plane, AT is a better option than other landmarks. MATERIALS AND METHODS: This retrospective study was done on 53 ankle MRIs that met the criteria for inclusion to the study among 158 ankle MRIs...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28144148/advances-in-the-management-of-cardiovascular-risk-for-patients-with-type-2-diabetes-perspectives-from-the-academy-for-cardiovascular-risk-outcomes-and-safety-studies-in-type-2-diabetes
#9
Guntram Schernthaner, Sarah Jarvis, Chaim Lotan, Martin Prázný, Christoph Wanner, Thomas C Wascher
Diabetes is a global health emergency projected to affect 642 million people by 2040. Type 2 diabetes (T2D) represents 90% of diabetes cases and is associated with a range of cardiovascular (CV) risk factors that are more than double the incidence of CV disease and significantly increase mortality rates. Diabetes treatments have typically focused on improving glycemic control but their effect on CV outcomes has remained uncertain. In 2008, the US Food and Drug Administration (FDA) looked to address this knowledge gap and mandated CV outcome trials (CVOTs) for all new antidiabetic therapies...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28138249/propylthiouracil-induced-liver-failure-and-artificial-liver-support-systems-a-case-report-and-review-of-the-literature
#10
Dong-Bo Wu, En-Qiang Chen, Lang Bai, Hong Tang
BACKGROUND: Antithyroid drugs carry a potential risk of hepatotoxicity. Propylthiouracil (PTU) is commonly prescribed for patients with hyperthyroidism. PTU, however, can induce liver injury, ranging from mild asymptomatic elevation of aminotransferases to acute liver failure (ALF). CASE PRESENTATION: This case reports on a 16-year-old Chinese girl with hyperthyroidism, who was admitted to our hospital for jaundice, nausea, and fatigue associated with severe hyperbilirubinemia and coagulopathy...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28138248/rapid-virological-response-of-telaprevir-and-boceprevir-in-a-brazilian-cohort-of-hcv-genotype-1-patients-a-multicenter-longitudinal-study
#11
Helena Hl Borba, Astrid Wiens, Laiza M Steimbach, Fernanda S Tonin, Maria LA Pedroso, Cláudia Ap Ivantes, Fernando Fernandez-Llimos, Roberto Pontarolo
BACKGROUND: Chronic hepatitis C is a major public health issue, but there is a gap in the literature regarding the effectiveness and safety of direct-acting antiviral agents in the Brazilian population. The main aim of this study was to describe the effectiveness of boceprevir and telaprevir in patients treated at public health care institutions in Brazil. MATERIALS AND METHODS: A prospective longitudinal and multicenter study was conducted in five centers in the State of Paraná between September 2014 and June 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28123300/the-association-of-nephrolithiasis-with-metabolic-syndrome-and-its-components-a-cross-sectional-analysis
#12
Yen-Tze Liu, Pei-Yu Yang, Yu-Wen Yang, Hung-Yu Sun, I-Ching Lin
BACKGROUND: Metabolic syndrome is a worldwide disorder and also the major risk factor of several systemic diseases. Evidence identifying the association between metabolic syndrome and nephrolithiasis is lacking, especially in Taiwan. AIM: The aim of this study was to investigate the association between nephrolithiasis and metabolic syndrome and its components. DESIGN AND SETTING: This was a cross-sectional study conducted in the Health Examination Department of a medical center in Changhua, Taiwan, from January 2010 to December 2010...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28115852/prognostic-role-of-copeptin-with-all-cause-mortality-after-heart-failure-a-systematic-review-and-meta-analysis
#13
Peng Zhang, Xiaomei Wu, Guangxiao Li, Hao Sun, Jingpu Shi
BACKGROUND: As the C-terminal section of vasopressin precursor, copeptin has been recently suggested as a new prognostic biomarker after heart failure (HF). Thus, the aim of this study was to evaluate the prognostic value of plasma copeptin level with all-cause mortality in patients with HF. METHODS: Comprehensive strategies were used to search relevant studies from electronic databases. Pooled hazard ratios (HRs) and standardized mean differences (SMDs) together with their 95% confidence intervals (CIs) were calculated...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28096679/a-phase-ii-single-arm-trial-of-palonosetron-for-the-prevention-of-acute-and-delayed-chemotherapy-induced-nausea-and-vomiting-in-malignant-glioma-patients-receiving-multidose-irinotecan-in-combination-with-bevacizumab
#14
Mary Lou Affronti, Sarah Woodring, Katherine B Peters, James E Herndon, Frances McSherry, Patrick N Healy, Annick Desjardins, James J Vredenburgh, Henry S Friedman
PURPOSE: Given that the prognosis of recurrent malignant glioma (MG) remains poor, improving quality of life (QoL) through symptom management is important. Meta-analyses establishing antiemetic guidelines have demonstrated the superiority of palonosetron (PAL) over older 5-hydroxytryptamine 3-receptor antagonists in chemotherapy-induced nausea and vomiting (CINV) prevention, but excluded patients with gliomas. Irinotecan plus bevacizumab is a treatment frequently used in MG, but is associated with low (55%) CINV complete response (CR; no emesis or use of rescue antiemetic) with commonly prescribed ondansetron...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28053537/comparison-of-intra-arterial-chemoembolization-with-and-without-radiotherapy-for-advanced-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-meta-analysis
#15
Qianqian Zhao, Kunli Zhu, Jinbo Yue, Zhonghua Qi, Shumei Jiang, Xiaoqing Xu, Rui Feng, Renben Wang
PURPOSE: Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). However, the efficacy of TACE or HAIC combined with RT versus TACE or HAIC alone remains controversial. Thus, we performed a meta-analysis to compare the efficacy and safety of intra-arterial chemoembolization combined with RT versus intra-arterial chemoembolization alone for the treatment of HCC patients with PVTT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28053536/identification-of-a-new-mutation-in-an-iranian-family-with-hereditary-multiple-osteochondromas
#16
Susan Akbaroghli, Maryam Balali, Behnam Kamalidehghan, Siamak Saber, Omid Aryani, Goh Yong Meng, Massoud Houshmand
BACKGROUND: Hereditary multiple osteochondromas (HMO), previously named hereditary multiple exostoses (HME), is an autosomal dominant skeletal disorder characterized by the growth of multiple osteochondromas and is associated with bony deformity, skeletal growth reduction, nerve compression, restriction of joint motion, and premature osteoarthrosis. HMO is genetically heterogeneous, localized on at least three chromosomal loci including 8q24.1 (EXT1), 11p11-p13 (EXT2), and 19p (EXT3)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28031716/diagnostic-accuracy-of-nodular-gastritis-for-h-pylori-infection
#17
Juan L Romero-Flores, Justo A Fernandez-Rivero, Erika Marroquín-Fabian, Félix I Téllez-Ávila, Beatriz A Sánchez-Jiménez, Eva Juárez-Hernández, Misael Uribe, Norberto C Chávez-Tapia
BACKGROUND: The term nodular is not included in the Sydney classification and there is no widely accepted histopathological definition. It has been proposed that the presence of antral nodularity could predict Helicobacter pylori (H. pylori) infection. The aim of this study was to determine the diagnostic accuracy of nodular gastritis (NG) for H. pylori infection after a rigorous standardization process, and to describe the associated histopathological characteristics. MATERIALS AND METHODS: Endoscopic images of patients submitted to endoscopy with biopsy sampling were included...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28031715/urinary-tract-infections-in-romanian-patients-with-diabetes-prevalence-etiology-and-risk-factors
#18
Teodora Chiţă, Bogdan Timar, Delia Muntean, Luminiţa Bădiţoiu, Florin Horhat, Elena Hogea, Roxana Moldovan, Romulus Timar, Monica Licker
AIM: Patients with diabetes mellitus (DM) have an increased risk of infections, especially urinary tract infections (UTIs). The aim of this study was to assess the prevalence and etiology of UTIs and identify the risk factors for their development in patients with DM. PATIENTS AND METHODS: In this retrospective, noninterventional study, the medical records of 2,465 adult patients with DM who were hospitalized in a Diabetes Clinic were reviewed. Data regarding the presence of UTI and possible associated risk factors were collected and their possible relation was analyzed...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28008264/impact-of-preoperative-chronic-renal-failure-on-liver-transplantation-a-population-based-cohort-study
#19
Peter Chi-Ho Chung, Hsiu-Pin Chen, Jr-Rung Lin, Fu-Chao Liu, Huang-Ping Yu
PURPOSE: The purpose of this study was to assess whether preoperative chronic renal failure (CRF) affects the rates of postoperative complications and survival after liver transplantation. METHODS: This population-based retrospective cohort study included 2,931 recipients of liver transplantation performed between 1998 and 2012, enrolled from the Taiwan National Health Insurance Research Database. Patients were divided into two groups, based on the presence or absence of preoperative CRF...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28008263/clinical-features-of-brain-metastases-in-breast-cancer-an-implication-for-hippocampal-sparing-whole-brain-radiation-therapy
#20
San-Gang Wu, Jia-Yuan Sun, Qin Tong, Feng-Yan Li, Zhen-Yu He
OBJECTIVE: The objectives of this study were to describe the distribution of brain metastases (BM) in breast cancer patients and investigate the risk factors for perihippocampal metastases (PHM). PATIENTS AND METHODS: Retrospective analysis of the clinicopathological characteristics and patterns of BM was performed. Associations between clinicopathological characteristics and PHM (the hippocampus plus 5 mm margin) were evaluated using logistic regression analyses...
2016: Therapeutics and Clinical Risk Management
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