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Therapeutics and Clinical Risk Management

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https://www.readbyqxmd.com/read/29343964/achalasia-following-reflux-disease-coincidence-consequence-or-accommodation-an-experience-based-literature-review
#1
András Vereczkei, Laura Bognár, András Papp, Örs Péter Horváth
Achalasia is a motility disorder of the esophagus characterized by the defective peristaltic activity of the esophageal body and impaired relaxation of the lower esophageal sphincter due to the degeneration of the inhibitory neurons in the myenteric plexus of the esophageal wall. The histopathological and pathophysiological changes in achalasia have been well described. However, the exact etiological factors leading to the disease still remain unclear. Currently, achalasia is believed to be a multifactorial disease, involving both extrinsic and intrinsic factors...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29317824/selection-of-piperacillin-tazobactam-infusion-mode-guided-by-sofa-score-in-cancer-patients-with-hospital-acquired-pneumonia-a-randomized-controlled-study
#2
Yang Lyu, Yang Yang, Xin Li, Min Peng, Xin He, Peng Zhang, Shangwen Dong, Wanhua Wang, Donghao Wang
Background: This study aimed to select piperacillin/tazobactam (TZP) infusion mode guided by Sequential Organ Failure Assessment (SOFA) score in cancer patients with hospital-acquired pneumonia (HAP) postoperation. Patients and methods: A total of 120 cancer patients with postoperative HAP were divided into two groups: improved administration group (L group) and conventional treatment group (Con group). The Con group received traditional infusion of TZP and the L group received it as prolonged infusion...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29317823/european-perspective-on-the-management-of-rheumatoid-arthritis-clinical-utility-of-tofacitinib
#3
REVIEW
Paweł Kawalec, Katarzyna Śladowska, Iwona Malinowska-Lipień, Tomasz Brzostek, Maria Kózka
Xeljanz® (tofacitinib) is an oral small-molecule inhibitor that reversibly inhibits Janus-activated kinase (JAK)-dependent cytokine signaling, thus reducing inflammation. As a result of these mechanisms, effects on the immune system such as a moderate decrease in the total lymphocyte count, a dose-dependent decrease in natural killer (NK) cell count, and an increase in B-cell count have been observed. Therefore, tofacitinib provides an innovative approach to modulating the immune and inflammatory responses in patients with rheumatoid arthritis (RA), which is especially important in individuals who do not respond to tumor necrosis factor inhibitors or show a loss of response over time...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29297514/regarding-the-descemetorhexis-for-anterior-synechiolysis-prior-to-endothelial-keratoplasty
#4
COMMENT
Sang Beom Han
No abstract text is available yet for this article.
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29296087/examining-hemodialyzer-membrane-performance-using-proteomic-technologies
#5
REVIEW
Mario Bonomini, Luisa Pieroni, Lorenzo Di Liberato, Vittorio Sirolli, Andrea Urbani
The success and the quality of hemodialysis therapy are mainly related to both clearance and biocompatibility properties of the artificial membrane packed in the hemodialyzer. Performance of a membrane is strongly influenced by its interaction with the plasma protein repertoire during the extracorporeal procedure. Recognition that a number of medium-high molecular weight solutes, including proteins and protein-bound molecules, are potentially toxic has prompted the development of more permeable membranes. Such membrane engineering, however, may cause loss of vital proteins, with membrane removal being nonspecific...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29290686/clinical-characteristics-of-cytomegalovirus-colitis-a-15-year-experience-from-a-tertiary-reference-center
#6
Puo-Hsien Le, Wey-Ran Lin, Chia-Jung Kuo, Ren-Chin Wu, Jun-Te Hsu, Ming-Yao Su, Chun-Jung Lin, Cheng-Tang Chiu
Background: Cytomegalovirus (CMV) colitis is considered rare in immunocompetent patients. Objective: The predictors of mortality and the differences between immunocompetent and immunocompromised patients with this disease remain unknown. Thus, the aim of this retrospective cohort study was to clarify these issues. Patients and methods: We enrolled all patients who were histologically diagnosed with CMV colitis between April 2002 and December 2016 in the Linkou Chang Gung Memorial Hospital...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29276389/predictors-of-acute-pancreatitis-with-low-elevation-of-serum-amylase
#7
Wandong Hong, Wujun Geng, Bicheng Chen, Zarrin Basharat, Qingsong Wu, Vincent Zimmer, Mengtao Zhou
Background and aims: Serum amylase is a traditional measure used to establish the diagnosis of acute pancreatitis (AP). The current study aimed to assess the predictors and clinical outcome of AP with low serum amylase. Methods: All patients were divided into two groups, based on their serum amylase level within the first 2 days after hospital admission: group 1 (amylase ≥300 U/L) and group 2 (amylase <300 U/L). Clinical outcomes were compared between the two groups before and after 1:1 propensity score matching...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29276388/relevance-of-positive-cardiovascular-outcome-trial-results-in-clinical-practice-perspectives-from-the-academy-for-cardiovascular-risk-outcomes-and-safety-studies-in-type-2-diabetes-across-t2d
#8
Guntram Schernthaner, Kamlesh Khunti, Chaim Lotan, Michel Burnier, Heinz Drexel, Martin Prázný
Type 2 diabetes (T2D) imposes a substantial disease burden, predominantly from cardiovascular disease (CVD), which accounts for >50% of deaths in this population and leads to a 12-year reduction in the life expectancy of a 60-year-old male patient with T2D and CVD compared with the general population. The results from mandatory cardiovascular outcome trials (CVOTs) are therefore of great interest in the field. The Academy for Cardiovascular Risk, Outcomes and Safety Studies in Type 2 Diabetes meeting program aims to bring together experts from several associated disciplines to provide fair and balanced resources for those involved in the management of patients with T2D...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29270015/effect-of-a-novel-nutraceutical-combination-on-serum-lipoprotein-functional-profile-and-circulating-pcsk9
#9
Maria Pia Adorni, Nicola Ferri, Silvia Marchianò, Valentina Trimarco, Francesco Rozza, Raffaele Izzo, Franco Bernini, Francesca Zimetti
Background: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by reducing proprotein convertase subtilisin kexin type 9 (PCSK9), independently of lipoprotein concentrations. Aim: We aimed to evaluate the effect of an innovative nutraceutical (NUT) combination containing red yeast rice (monacolin K 3...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29263673/incidence-and-risk-factors-of-poor-clinical-outcomes-in-patients-with-cervical-kyphosis-after-cervical-surgery-for-spinal-cord-injury
#10
Yanwei Zhang, Jia Li, Yongqian Li, Yong Shen
Objective: This retrospective study investigated the incidence and risk factors of poor clinical outcomes after cervical surgery for cervical spinal cord injury in a large population of patients with global or segmental cervical kyphosis. Methods: The clinical and radiological evaluation results of 269 patients with cervical kyphosis who underwent either anterior or posterior surgery between 2008 and 2013 were collected, preoperatively and at each follow-up after surgery...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29255362/mortality-risk-factors-during-readmission-at-the-department-of-medicine
#11
Chayanis Trakulthong, Anakapong Phunmanee
Background: Readmission is an indicator of quality of inpatient care. A study from Hong Kong found readmission mortality rate to be 5.1%. There are limited reports on risk factors for mortality other than co-morbid diseases in readmission patients. This study, thus, aims to evaluate risk factors for mortality during readmission. Methods: This study was conducted at a university hospital in Thailand. The inclusion criteria were patients aged ≥15 years and readmission to internal medicine wards within 28 days after discharge...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29238199/outcome-and-safety-of-tailored-surgical-treatments-of-nonmalignant-esophagotracheobronchial-fistula-report-of-fourteen-patients
#12
Feng Guo, Zhiyong Zhang, Yushang Cui, Li Li, Xiaohui Xu, Shanqing Li
Introduction: Acquired benign esophageal tracheobronchial fistulae are clinically rare. In this paper, we summarize our experiences in surgical treatment of 14 consecutive patients with acquired benign esophageal tracheobronchial fistula. Methods: This series included patients who underwent surgery between January 2002 and June 2015 at our institution. We retrieved and analyzed data on demographics, operative characteristics, and surgical outcome of the patients...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29238198/oral-microbiome-and-peri-implant-diseases-where-are-we-now
#13
REVIEW
Rafał Pokrowiecki, Agnieszka Mielczarek, Tomasz Zaręba, Stefan Tyski
Peri-implant infective diseases (PIIDs) in oral implantology are commonly known as peri-implant mucositis (PIM) and periimplantitis (PI). While PIM is restricted to the peri-implant mucosa and is reversible, PI also affects implant-supporting bone and, therefore, is very difficult to eradicate. PIIDs in clinical outcome may resemble gingivitis and periodontitis, as they share similar risk factors. However, recent study in the field of proteomics and other molecular studies indicate that PIIDs exhibit significant differences when compared to periodontal diseases...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29225468/therapy-of-an-incomplete-spinal-cord-injury-by-intrathecal-injection-of-epo-and-subcutaneous-injection-of-epo-vitamin-c-and-g-csf
#14
Augustinus Bader, Martin Reinhardt, Achim Beuthe, Klaus Röhl, Shibashish Giri
Spinal cord injury is a rare disease with an incidence about 40 cases per million population in the USA. The most common reasons are traffic accidents, falls, violence and sports. A 53-year-old male patient presented with an incomplete tetraparesis as a result of a spinal cord injury after the accident. It was not possible to treat him with steroids because he was out of the therapeutic time period of 8 hours when he presented to the hospital. The main problem of spinal cord injuries is the secondary injury caused by inflammation and swelling of the spinal cord...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29200862/association-between-serum-cystatin-c-and-bone-mineral-density-in-korean-adults
#15
Dongwon Yi, Ah Reum Khang, Hye Won Lee, Seok Man Son, Yang Ho Kang
Background: Serum cystatin C has been known as a novel marker of preclinical renal dysfunction, and higher cystatin C levels are associated with increased risks of hip and nonvertebral fractures. However, there are few reports on the association between serum cystatin C and bone mineral density (BMD), especially in the Asian population. We evaluated the association between cystatin C levels and BMD of the spine and hip in Korean adults. Methods: A cross-sectional study was performed in 865 Korean adults (325 men and 540 women) who participated in a comprehensive medical examination program and underwent bone densitometry...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29200861/statin-therapy-for-preventing-cardiovascular-diseases-in-patients-treated-with-tacrolimus-after-kidney-transplantation
#16
Nayoung Han, Seung Hee Han, Yun-Kyoung Song, Myeong Gyu Kim, Yon Su Kim, In-Wha Kim, Jung Mi Oh
Background: Lipid abnormalities are prevalent in tacrolimus-treated patients. The aim of the study was to evaluate the preventive effects of statin therapy on major adverse cardiovascular events (MACE) in patients treated with tacrolimus-based immunosuppression after kidney transplantation (KT), and to identify the risk factors. Methods: This observational cohort study included adult patients who underwent KT and were treated with tacrolimus. Patients who received any lipid-lowering agents except statins, or had a history of immunosuppressant use before transplantation were excluded...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29184415/reversible-preoperative-renal-dysfunction-does-not-add-to-the-risk-of-postoperative-acute-kidney-injury-after-cardiac-valve-surgery
#17
Jia-Rui Xu, Ya-Min Zhuang, Lan Liu, Bo Shen, Yi-Mei Wang, Zhe Luo, Jie Teng, Chun-Sheng Wang, Xiao-Qiang Ding
Objective: To evaluate the impact of the renal dysfunction (RD) type and change of postoperative cardiac function on the risk of developing acute kidney injury (AKI) in patients who underwent cardiac valve surgery. Method: Reversible renal dysfunction (RRD) was defined as preoperative RD in patients who had not been initially diagnosed with chronic kidney disease (CKD). Cardiac function improvement (CFI) was defined as postoperative left ventricular ejection function - preoperative left ventricular ejection function (ΔEF) >0%, and cardiac function not improved (CFNI) as ΔEF ≤0%...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29184414/omentum-flap-as-a-salvage-procedure-in-deep-sternal-wound-infection
#18
COMMENT
Franjo Rudman, Davor Barić, Daniel Unić
No abstract text is available yet for this article.
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29184413/near-fatal-asthma-responsive-to-mepolizumab-after-failure-of-omalizumab-and-bronchial-thermoplasty
#19
Francesco Menzella, Carla Galeone, Mirco Lusuardi, Anna Simonazzi, Claudia Castagnetti, Patrizia Ruggiero, Nicola Facciolongo
Severe asthma affects between 5% and 10% of patients with asthma worldwide and requires best standard therapies at maximal doses, but there is a subgroup of patients refractory to all treatments. We share a case report of a 53-year-old woman with a history of severe allergic asthma that progressively worsened over the years despite the best therapy. She had been hospitalized 35 times, including nine admissions to the respiratory intensive care unit due to severe exacerbations. To rule out other possible diagnoses, several investigations were performed, such as computed tomography scan of the chest and neck, fiberoptic laryngoscopy, antineutrophil cytoplasmic antibodies, and complete blood cell count...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29184412/a-6-year-study-of-complicated-urinary-tract-infections-in-southern-china-prevalence-antibiotic-resistance-clinical-and-economic-outcomes
#20
Xiaoyan Li, Yunqin Chen, Weiguo Gao, Hao Ye, Zhongchao Shen, Zehuai Wen, Jia Wei
Urinary tract infections (UTIs) are common nosocomial infections. This study evaluated the prevalence, pathogens, antibiotic resistances, clinical outcomes, and hospitalization costs associated with complicated UTIs in southern China, and risk factors delaying patient discharge. We retrospectively reviewed electronic medical records of 4,284 (61.4% women) complicated UTI-related hospitalizations from 2008 to 2013. Average patient age was 61.1 years and median hospital stay was 11 days. Pathogens were isolated from 1,071 urine and 148 blood specimens...
2017: Therapeutics and Clinical Risk Management
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