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Organogenesis

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https://www.readbyqxmd.com/read/29461900/suppression-of-lrrc19-promotes-cutaneous-wound-healing-in-pressure-ulcers-in-mice
#1
Jie Sun, Zhijing Wang, Xirui Wang
The ischemia-reperfusion (I/R) induced skin lesion has been identified as primary cause of pressure ulcer. Better understanding of the mechanism is required for new therapy development. Leucine rich repeat containing protein 19 (LRRC19) is a recently discovered transmembrane protein containing leucine-rich repeats and plays a role in immune response. To investigate the role of LRRC19 in pressure ulcers, mouse ulcer model was established with two cycles of I/R. The expression of LRRC19 was assessed during injury...
February 20, 2018: Organogenesis
https://www.readbyqxmd.com/read/29420128/effe0cts-of-porcine-acellular-dermal-matrix-treatment-on-wound-healing-and-scar-formation-role-of-jag1-expression-in-epidermal-stem-cells
#2
Xiao-Dong Chen, Shu-Bin Ruan, Ze-Peng Lin, Ziheng Zhou, Feng-Gang Zhang, Rong-Hua Yang, Ju-Lin Xie
Skin wound healing involves Notch/Jagged1 signaling. However, little is known how Jag1 expression level in epidermal stem cells (ESCs) contributes to wound healing and scar formation. We applied multiple cellular and molecular techniques to examine how Jag1 expression in ESCs modulates ESCs differentiation to myofibroblasts (MFB) in vitro, interpret how Jag1 expression in ESCs is involved in wound healing and scar formation in mice, and evaluate the effects of porcine acellular dermal matrix (ADM) treatment on wound healing and scar formation...
February 8, 2018: Organogenesis
https://www.readbyqxmd.com/read/29420124/embryonic-skin-development-and-repair
#3
Michael S Hu, Mimi R Borrelli, Wan Xing Hong, Samir Malhotra, Alexander T M Cheung, Ryan C Ransom, Robert C Rennert, Shane D Morrison, H Peter Lorenz, Michael T Longaker
Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes...
February 8, 2018: Organogenesis
https://www.readbyqxmd.com/read/29359998/prolongation-of-liver-specific-function-for-primary-hepatocytes-maintenance-in-3d-printed-architectures
#4
Yohan Kim, Kyojin Kang, Sangtae Yoon, Ji Sook Kim, Su A Park, Wan Doo Kim, Seung Bum Lee, Ki-Young Ryu, Jaemin Jeong, Dongho Choi
Isolated primary hepatocytes from the liver are very similar to in vivo native liver hepatocytes, but they have the disadvantage of a limited lifespan in 2D culture. Although a sandwich culture and 3D organoids with mesenchymal stem cells (MSCs) as an attractive assistant cell source to extend lifespan can be used, it cannot fully reproduce the in vivo architecture. Moreover, long-term 3D culture leads to cell death because of hypoxic stress. Therefore, to overcome the drawback of 2D and 3D organoids, we try to use a 3D printing technique using alginate hydrogels with primary hepatocytes and MSCs...
January 23, 2018: Organogenesis
https://www.readbyqxmd.com/read/29293384/corrigendum
#5
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2018: Organogenesis
https://www.readbyqxmd.com/read/29173023/the-epidemiology-of-supernumerary-teeth-and-the-associated-molecular-mechanism
#6
Xi Lu, Fang Yu, Junjun Liu, Wenping Cai, Yumei Zhao, Shouliang Zhao, Shangfeng Liu
No abstract text is available yet for this article.
November 27, 2017: Organogenesis
https://www.readbyqxmd.com/read/29027839/ephb-receptors-mainly-ephb3-contribute-to-the-proper-development-of-cortical-thymic-epithelial-cells
#7
Sara Montero-Herradón, Javier García-Ceca, Agustín G Zapata
EphB and their ligands ephrin-B are an important family of protein tyrosine kinase receptors involved in thymocyte-thymic epithelial cell interactions known to be key for the maturation of both thymic cell components. In the present study, we have analyzed the maturation of cortical thymic epithelium in EphB-deficient thymuses evaluating the relative relevance of EphB2 and EphB3 in the process. Results support a relationship between the epithelial hypocellularity of mutant thymuses and altered development of thymocytes, lower proportions of cycling thymic epithelial cells and increased epithelial cell apoptosis...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/29020571/factors-and-molecules-that-could-impact-cell-differentiation-in-the-embryo-generated-by-nuclear-transfer
#8
Renata Simões, Arnaldo Rodrigues Santos
Somatic cell nuclear transfer is a technique to create an embryo using an enucleated oocyte and a donor nucleus. Nucleus of somatic cells must be reprogrammed in order to participate in normal development within an enucleated egg. Reprogramming refers to the erasing and remodeling of cellular epigenetic marks to a lower differentiation state. Somatic nuclei must be reprogrammed by factors in the oocyte cytoplasm to a rather totipotent state since the reconstructed embryo must initiate embryo development from the one cell stage to term...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28934068/upper-limb-hemimelia-in-a-twin-pregnancy-which-was-obtained-by-an-icsi-and-pgd-in-a-woman-with-mosaic-turner-s-syndrome-and-the-prognosis
#9
Ahter Tanay Tayyar, Ahmet Tayyar, Ahmet Eser, Çetin Kılıçcı, İlter Yenidede, Selçuk Selçuk
Turner's syndrome (TS) is depicted as a total or partial absence of X chromosome, and occurs in approximately 1/2200 of live born females. Generally, mosaic patients are diagnosed following karyotype analysis due to recurrent pregnancy loss, repeated in vitro fertilization (IVF) failure, and a history of malformed babies. The purpose of this case report is to show that even a selection of normal karyotype embryos can result in abnormalities for those with mosaic TS. A 32-year old patient who underwent IVF after ICSI-PGD, and was diagnosed with 45X/46XX karyotype...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28933666/regulation-of-proliferation-in-developing-human-tooth-germs-by-msx-homeodomain-proteins-and-cyclin-dependent-kinase-inhibitor-p19ink4d
#10
Darko Kero, Katarina Vukojevic, Petra Stazic, Danijela Sundov, Snjezana Mardesic Brakus, Mirna Saraga-Babic
Before the secretion of hard dental tissues, tooth germs undergo several distinctive stages of development (dental lamina, bud, cap and bell). Every stage is characterized by specific proliferation patterns, which is regulated by various morphogens, growth factors and homeodomain proteins. The role of MSX homeodomain proteins in odontogenesis is rather complex. Expression domains of genes encoding for murine Msx1/2 during development are observed in tissues containing highly proliferative progenitor cells. Arrest of tooth development in Msx knockout mice can be attributed to impaired proliferation of progenitor cells...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28933645/rar%C3%AE-and-rar%C3%AE-reciprocally-control-k5-progenitor-cell-expansion-in-developing-salivary-glands
#11
Kara A DeSantis, Adam R Stabell, Danielle C Spitzer, Kevin J O'Keefe, Deirdre A Nelson, Melinda Larsen
Understanding the mechanisms of controlled expansion and differentiation of basal progenitor cell populations during organogenesis is essential for developing targeted regenerative therapies. Since the cytokeratin 5-positive (K5+ ) basal epithelial cell population in the salivary gland is regulated by retinoic acid signaling, we interrogated how isoform-specific retinoic acid receptor (RAR) signaling impacts the K5+ cell population during salivary gland organogenesis to identify RAR isoform-specific mechanisms that could be exploited in future regenerative therapies...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28933641/the-effect-of-a-silk-fibroin-polyurethane-blend-patch-on-rat-vessels
#12
Kazumi Shimada, Akira Higuchi, Ryota Kubo, Tomoaki Murakami, Yasumoto Nakazawa, Ryou Tanaka
Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation of vascular stenosis. Expanded polytetrafluoroethylene (ePTFE) patches are flexible and handle well, but have shown problems with calcification as they are non-bioabsorbable and therefore permanently remain in the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed as a biocompatible material, but it lacks of the elasticity required for surgery as a patch. Polyurethane (PU) is also a well-known elastomer so this study focused on the SF and the PU blend materials with a weight ratio of 5:5 (SF/PU)...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28933636/nicotinic-acid-inhibits-angiogenesis-likely-through-cytoskeleton-remodeling
#13
Lemen Pan, Guanfeng Yu, Xiangjian Chen, Xiaoqiang Li
Angiogenesis is a physiological procedure during which the new blood vessels develop from the pre-existing vessels. Uncontrolled angiogenesis is related to various diseases including cancers. Clinical inhibition of undesired angiogenesis is still under investigation. We utilized nicotinic acid, a family member of the B-vitamin niacin (vitamin B3) that has been used in the prevention and treatment of atherosclerosis or other lipid-metabolic disorders, to treat human umbilical vein endothelial cells (HUVECs) and chick chorioallantoic membrane (CAM), and investigated its influence on angiogenesis in vitro and in vivo...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/29064338/corrigendum
#14
(no author information available yet)
No abstract text is available yet for this article.
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28598297/the-neuronal-differentiation-microenvironment-is-essential-for-spinal-cord-injury-repair
#15
Yannan Zhao, Zhifeng Xiao, Bing Chen, Jianwu Dai
Spinal cord injury (SCI) often leads to substantial disability due to loss of motor function and sensation below the lesion. Neural stem cells (NSCs) are a promising strategy for SCI repair. However, NSCs rarely differentiate into neurons; they mostly differentiate into astrocytes because of the adverse microenvironment present after SCI. We have shown that myelin-associated inhibitors (MAIs) inhibited neuronal differentiation of NSCs. Given that MAIs activate epidermal growth factor receptor (EGFR) signaling, we used a collagen scaffold-tethered anti-EGFR antibody to attenuate the inhibitory effects of MAIs and create a neuronal differentiation microenvironment for SCI repair...
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28598258/the-epidemiology-of-supernumerary-teeth-and-the-associated-molecular-mechanism
#16
Xi Lu, Fang Yu, Junjun Liu, Wenping Cai, Yumei Zhao, Shouliang Zhao, Shangfeng Liu
Supernumerary teeth are common clinical dental anomalies. Although various studies have provided abundant information regarding genes and signaling pathways involved in tooth morphogenesis, which include Wnt, FGF, BMP, and Shh, the molecular mechanism of tooth formation, especially for supernumerary teeth, is still unclear. In the population, some cases of supernumerary teeth are sporadic, while others are syndrome-related with familial hereditary. The prompt and accurate diagnosis of syndrome related supernumerary teeth is quite important for some distinctive disorders...
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28598248/enamel-matrix-derivative-enhances-the-proliferation-and-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-on-the-titanium-implant-surface
#17
Guang Li, Jing Hu, Hui Chen, Liang Chen, Na Zhang, Lisheng Zhao, Ning Wen, Yongjin Yang
Periodontal ligament stem cells (PDLSCs) have mesenchymal-stem-cells-like qualities, and are considered as one of the candidates of future clinical application in periodontal regeneration therapy. Enamel matrix derivative (EMD) is widely used in promoting periodontal regeneration. However, the effects of EMD on the proliferation and osteogenic differentiation of human PDLSCs grown on the Ti implant surface are still no clear. Therefore, this study examined the effects of EMD on human PDLSCs in vitro. Human PDLSCs were isolated from healthy participants, and seeded on the surface of Ti implant disks and stimulated with various concentrations of EMD...
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28548903/microenvironment-of-a-tumor-organoid-system-enhances-hepatocellular-carcinoma-malignancy-related-hallmarks
#18
Yang Wang, Kazuki Takeishi, Zhao Li, Eduardo Cervantes-Alvarez, Alexandra Collin de l'Hortet, Jorge Guzman-Lepe, Xiao Cui, Jiye Zhu
Organ-like microenviroment and 3-dimensional (3D) cell culture conformations have been suggested as promising approaches to mimic in a micro-scale a whole organ cellular functions and interactions present in vivo. We have used this approach to examine biologic features of hepatocellular carcinoma (HCC) cells. In this study, we demonstrate that hepatocellular carcinoma (HCC) cells, fibroblasts, endothelial cells and extracellular matrix can generate organoid-like spheroids that enhanced numerous features of human HCC observed in vivo...
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28486048/endometriosis-origin-from-primordial-germ-cells
#19
Zograb Makiyan
Endometriosis is defined by the presence of endometrial ectopia. Multiple hypotheses have been postulated to explain the etiology of endometriosis to understand various clinical evidences. The etiology of endometriosis is still unclear.The primary question to understanding the etiology of endometrial ectopia (endometriosis) is determining the origin of eutopic (normally cited) endometrium.According to the new theory, primordial germ cells migrate from hypoblast (yolk sac close to the allantois) to the gonadal ridges...
July 3, 2017: Organogenesis
https://www.readbyqxmd.com/read/28277890/analysis-of-spatiotemporal-pattern-and-quantification-of-gastrointestinal-slow-waves-caused-by-anticholinergic-drugs
#20
Kelvin K L Wong, Lauren C Y Tang, Jerry Zhou, Vincent Ho
Anticholinergic drugs are well-known to cause adverse effects, such as constipation, but their effects on baseline contractile activity in the gut driven by slow waves is not well established. In a video-based gastrointestinal motility monitoring (GIMM) system, a mouse's small intestine was placed in Krebs solution and recorded using a high definition camera. Untreated controls were recorded for each specimen, then treated with a therapeutic concentration of the drug, and finally, treated with a supratherapeutic dose of the drug...
April 3, 2017: Organogenesis
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