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Current Diabetes Reviews

Shaylee Peterson, Arden Barry
BACKGROUND: Cardiovascular disease is the leading cause of death in patients with type 2 diabetes. OBJECTIVE: To assess the impact of glucagon-like peptide-1 receptor agonist (GLP1RA) therapy, compared to placebo, on clinically relevant outcomes including all-cause mortality, cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, and hospitalizations for heart failure, in patients with type 2 diabetes. METHOD: EMBASE, MEDLINE, and CENTRAL were searched (inception to September 2016) for randomized, double-blind, placebo-controlled trials of at least one year in duration that compared any GLP1RA to placebo in patients with type 2 diabetes...
April 14, 2017: Current Diabetes Reviews
R Bishay, N Kormas
BACKGROUND: The global epidemic of obesity will see normal weight adults constituting a mere one-third of the global population by 2025. Although appetite and weight are regulated by a complex integration of neurological, endocrine and gastrointestinal feedback mechanisms, there is a constant interaction between psychological state, physical impairment, presence of comorbid chronic disease and medications. METHODS: We discuss two cases and reveal a practical approach to investigating and managing patients with obesity and diabetes in the 'real world'...
March 29, 2017: Current Diabetes Reviews
Judith Aponte, Karen Tejada, Mariel Acosta-Melo
BACKGROUND: Diabetes is a growing epidemic that is affecting Hispanics in high rates. INTRODUCTION: Although Hispanics use the internet for health-related informational and educational purposes, there is a lack of information available in the Spanish-language. METHODS: A review was conducted to examine the literature on internet-based, Spanish-language, diabetes focused information. One search was conducted, using three different databases (i...
March 15, 2017: Current Diabetes Reviews
Lia Bally, Hood Thabit
BACKGROUND: Despite its well-established health benefits, exercise imposes challenges on glucose control in individuals with type 1 diabetes due to to the complex interactions between exercise-induced effects on glucose metabolism and exogenous insulin therapy. Although clinical guidelines for exercise management in type 1 diabetes are available, implementation is challenging in daily -life. The risk of exercise-induced dysglycaemia deters many people with type 1 diabetes from participating and benefiting from exercise...
February 28, 2017: Current Diabetes Reviews
Yuxuan Wang, Chengcheng Wang, Xiuli Zhang, Harvest F Gu, Liang Wu
Diabetic nephropathy is characterized by hypertension, progressive albuminuria, glomerulosclerosis and declines in glomerular filtration rate leading to end stage renal disease. Although the pathogenesis of diabetic nephropathy is not fully understood, current treatment of the patients with diabetic nephropathy is mainly based upon the control of hyperglycaemia and management of blood pressures. Several drugs, which are originally developed for hypertension therapy, have been adopted for stabilization of renal function in diabetic nephropathy...
February 14, 2017: Current Diabetes Reviews
Susanne Irene Scott, Michelle Fog Andersen, Lise Aagaard, Christian Von Buchwald, Eva Rye Rasmussen
Introduction Angioedema is a potentially fatal adverse drug reaction of some medications, as swellings of the upper airways can cause death by asphyxiation. Angiotensin converting enzyme-inhibitors are widely known to cause angioedema but less is known about the association between dipeptidyl peptidase-4 inhibitors (gliptins) and angioedema. Dipeptidyl peptidase-4 inhibitors are anti-diabetic drugs used to improve glycaemic control. They, as a class effect, inadvertently affect the degradation of the vasoactive kinins bradykinin and substance P, both of which can cause angioedema due to vasodilatation and increase in vascular permeability in the capillaries...
February 14, 2017: Current Diabetes Reviews
Julienne K Kirk, Hannah Marie Devoid, Carmen Strickland
BACKGROUND: Diabetes is a demanding disease that is growing in prevalence. Improved outcomes for patients with diabetes are highly dependent on self-management skills and the ability to make lifestyle changes. Innovative healthcare approaches are necessary to meet these specific patient needs. A group care medical visit (GMV) combines diabetes check-ups with diabetes education in a supportive and patient centered environment that promotes effective self-management. GMVs are associated with improved diabetes outcomes including hemoglobin A1C, weight, and self-efficacy; however details of the methods by which content is delivered to achieve these outcomes remain vague...
February 3, 2017: Current Diabetes Reviews
Prasanna Santhanam, Wael Marashdeh, Lilja B Solnes
Introduction Gastroparesis (a complication of both type 1 and type 2 diabetes mellitus) is delayed gastric emptying in the absence of a mechanical obstruction. Overall prevalence of Gastroparesis is close to 5 % in type 1 diabetes and 1 % in type 2 diabetes. It is unclear if good glycemic control leads to delay of development and progression of gastroparesis. Methods Gastric enteric neurons as well as interstitial cells of Cajal (ICC) are depleted, truncated and are surrounded by immune infiltrates composed of macrophages...
January 26, 2017: Current Diabetes Reviews
Sze Lyn Jeanne Wong, Kim Christine Donaghue
Cardiovascular disease as a result of macrovascular changes is the leading cause of mortality in patients with type 1 diabetes (T1DM). While CVD complications are seen predominantly in adulthood, the atherosclerotic process begins in childhood and is accelerated in patients with T1DM. This review focuses on the epidemiology of traditional CVD risk factors in adolescents with T1DM, its association with markers of CVD and an overview of studies looking into each individual risk factor. The risk factors that are reviewed here are hypertension, dyslipidemia, smoking, obesity, lack of exercise, hyperglycemia and diabetic nephropathy...
January 23, 2017: Current Diabetes Reviews
Abdelhakim Ainahi, Abdelhamid Barakat, Lahcen Wakrim, Hicham Mohammadi, Naima El Mdaghri, Sayeh Ezzikouri
BACKGROUND: Recent studies have shown an inverse relationship between diabetes and prostate-specific antigen (PSA) levels. OBJECTIVE: In this study, we sought to evaluate the PSA levels in serum of diabetic and non-diabetic Moroccan males. METHODS: In a cross-sectional study, four hundred and seventy diabetic and 869 non-diabetic males were screened from January 2015 to April 2016 at Pasteur institute of Morocco. Hemoglobin A1c and Fasting Blood Glucose were measured using high performance liquid chromatography and dry chemistry, respectively...
January 17, 2017: Current Diabetes Reviews
Jose A Canas, Samuel S Gidding, Nelly Mauras
Despite recent advances in improved glycemic control, the magnitude of lifetime risk from premature cardiovascular disease in individuals with type 1 diabetes remains at least 10 fold higher than in the general population. The availability of lipoprotein fractionation has allowed the spotlight for this increased risk to shift from dysglycemia to diabetes-induced dyslipidemia associated with insulin resistance. Interventions designed to simultaneously improve both factors can have distinct and additive effects on slowing the initiation and progression of atherosclerotic lesions...
January 13, 2017: Current Diabetes Reviews
Sayantani Pramanik, Nirali Rathwa, Roma Patel, A V Ramachandran, Rasheedunnisa Begum
BACKGROUND: Diabetes has turned into a pandemic disorder that is affecting millions of people worldwide. Industries are aggressively racing and pursuing research towards the discovery of antidiabetic drug and the current global sale of such drugs are ever on the increase. However, in spite of such massive level and expenditure thereof, WHO projects that by 2030, diabetes will rank as the 7th leading cause of mortality. OBJECTIVE: It is in this context that we have reviewed here the various approaches available and possible towards diabetes management...
January 12, 2017: Current Diabetes Reviews
Madhukar Saxena, Neena Srivastava, Monisha Banerjee
Diabetes is third widespread after heart disease and cancer. We have investigated genetic polymorphisms in cytokine genes viz. IL-4, IL-1Ra, IL-1β, IL-18, IL-6, TNF-α, IL-10 and ADIPOQ. The aim of study was to investigate the haplotypes, gene-gene interactions and their role in determining individual susceptibility to T2DM of family members with diabetic history. Haplotype analysis of 2 SNPs each in IL-6 and adiponectin genes showing Pairwise Linkage disequilibrium (LD) was done by SHEsis software. Logistic regression was used to study various combinations of gene-gene interactions...
January 12, 2017: Current Diabetes Reviews
Nermin A Sheriba, Iman Z Ahmed, Mona M Abdesalam, Yara M Eid, Maram M Mahdy, Hany K Mansour
Insulin resistance may develop with Type 1 diabetes. Insulin resistance is currently recognized by estimated glucose disposal rate. Serum fetuin has been accused as a risk factor for metabolic syndrome. AIM: To determine the relationship between serum fetuin and insulin resistance in Type 1 diabetes subjects and the effect of short-term Metformin therapy on this relationship. METHOD: 40 T1DM male ≥ 18 years of age were screened for insulin resistance (defined using estimated glucose disposal rate)...
January 12, 2017: Current Diabetes Reviews
Norman E Cameron
No abstract text is available yet for this article.
2017: Current Diabetes Reviews
U Shrivastava, A Misra, V Mohan, R Unnikrishnan, D Bachani
Non-communicable diseases (NCDs; including coronary heart disease and type 2 diabetes) are rapidly increasing in India causing nearly 5.8 million deaths per year. Primary reasons for rise in NCDs in India are nutrition and lifestyle transitions. Further, presence of higher body fat, abdominal fat, liver and pancreatic fat and lower lean mass than whites, contribute to heightened metabolic and cardiovascular risk in Asian Indians. Importantly, conversion from pre-diabetes to diabetes occurs more rapidly, and reversion to normal glucose regulation with appropriate lifestyle measures is more difficult in Asian Indians than white population...
2017: Current Diabetes Reviews
Oleg V Udovichenko, N V Maximova, M V Amosova, O A Yunilaynen, E A Berseneva, E G Starostina
BACKGROUND: Depression and anxiety can potentially influence treatment results of diabetic complications. OBJECTIVE: Of our study was to explore: (1) prevalence of these disorders in patients with diabetic foot ulcers (DFU); (2) possible risk factors of depression and anxiety; (3) possible links between ulcer treatment results and depression/anxiety status. METHODS: 285 outpatients with diabetes and foot or leg ulcers were tested for depression and anxiety with self-report scales: CES-D and the anxiety subscale from HADS...
2017: Current Diabetes Reviews
Asirvatham Alwin Robert, Mohamed Abdulaziz Al Dawish, Rim Braham, Maha Ali Musallam, Ayman Abdullah Al Hayek, Nasser Hazza Al Kahtany
The World Health Organization has ranked Saudi Arabia as having the second highest rate of diabetes in the Middle East (7th highest in the world) with an estimated population of 7 million living with diabetes and more than 3 million with pre-diabetes. This presents a pressing public health problem. Several challenges in diabetes management need to be tackled in Saudi Arabia, including the growing prevalence (chiefly among children and young adults), micro-and macrovascular complications, lifestyle changes, late diagnosis, poor awareness and high treatment costs...
2017: Current Diabetes Reviews
Armin Mooranian, Rebecca Negrulj, Hani Al-Salami
BACKGROUND: In recent studies, we have incorporated bile acid and polyelectrolytes into pancreatic β-cell microcapsules and examined their cell viability and microcapsule morphology using various encapsulating methods. OBJECTIVE: This study aimed to incorporate 3 colloids; ultrasonic gel (USG; 1%), polystyrenic sulphate (PSS; 0.1%) and polyallylamine (PAA; 3%) and ursodeoxycholic acid (UDCA; 4%) with the polymer sodium alginate (SA; 1.2%) and the copolymer poly-L-ornithine (PLO; 1%), and using a refined vibrational jet-flow microencapsulating method, test the microcapsule properties, and cell viability without or with UDCA...
2017: Current Diabetes Reviews
Flavia Concetta Aiello, Francesca Maria Trovato, Marta Anna Szychlinska, Rosa Imbesi, Paola Castrogiovanni, Carla Loreto, Giuseppe Musumeci
BACKGROUND: Diabetes mellitus (DM) and osteoarthritis (OA) are two of the most relevant and common chronic diseases affecting older people. Both DM and OA are considered metabolic diseases due to their high correlation with the capacity of the body to metabolize some nutritive substances such as glucose, fat, vitamins and also the response to oxidative molecules. METHODS: We searched PubMed, Scopus, Google Scholar, and authors' bibliographies in order to extract articles regarding the relationship between DM and OA...
2017: Current Diabetes Reviews
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