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Current Diabetes Reviews

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https://www.readbyqxmd.com/read/29745337/factors-associated-with-poor-hemoglobin-a1c-control-in-patients-with-type-2-diabetes
#1
Salam Alqudah, Anan S Jarab, Eman A Alefishat, Fadia Mayyas, Maher Khdour, Sharrel Pinto
Background The limited implementation of clinical pharmacy service programs and the lack of studies identifying barriers to achieve blood glucose control have all attributed to the increased proportion of type 2 diabetes patients who have poor glycemic control in Jordan. Objective To explore factors associated with higher HbA1c in patients with type 2 diabetes in Jordan. Method Variables including socio-demographics, disease and treatment factors were collected from171 patients with type2 diabetes at an outpatient diabetes clinic in Amman...
May 10, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29692258/early-occurrence-cases-of-diabetes-mellitus-clinical-picture-in-two-major-tertiary-care-hospitals-in-india
#2
Nitin Joseph, Shreya Sharma, Vinisha Modi, Sanath Majunatha, Saad Arshad Siddiqui, Mihika Sinha
INTRODUCTION: Type 1 diabetes mellitus (T1D) is one of the most common endocrine disease in childhood. However, very limited information is available on this disease. OBJECTIVES: This study was done to assess risk factors, clinical features and management practices in T1D patients. METHODS: A review of records of 39 T1D cases admitted over the past five years in two hospitals was done. RESULTS: The mean age at diagnosis among males was 19...
April 24, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29692257/current-views-on-dopaminergic-drugs-affecting-glucose-homeostasis
#3
Mortaza Fatehi Hassanabad, Mohammad Fatehi
BACKGROUND: For more than three decades, it has been known that manipulation of dopaminergic system could affect glucose homesotasis in experimental animals. The notion that glucose homeostasis in human might be influenced by dopaminergic drugs has attracted a great deal of attention in the past two decades. In spite of rapid advancements in revealing involvement of dopaminergic neurotransmission in insulin release, glucose up-take and pancreatic beta cell function in general through centrally and peripherally controlled mechanisms, there are discrepancies among observations on experimental animals and human subjects...
April 24, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#4
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29663893/sglt-2-inhibition-novel-therapeutics-for-reno-and-cardioprotection-in-diabetes-mellitus
#5
Angus Gill, Stephen P Gray, Karin A Jandeleit-Dahm, Anna M D Watson
BACKGROUND: The sodium glucose co-transporter 2 (SGLT2) is primarily located within S1 of the renal proximal tubule being responsible for approximately 90% of glucose re-uptake in the kidney. Inhibition of SGLT2 is an exciting new pharmacological approach for the reduction of blood glucose in type 2 diabetic patients via inhibition of tubular glucose reabsorption. In addition to lowering glucose, this group of drugs has shown significant cardiovascular and renal protective effects. CONCLUSION: This review aims to outline the current state of preclinical research and clinical trials for different SGLT2 inhibitors and outline some of the proposed mechanisms of action, including possible effects on sympathetic nerve activity, which may contribute to the unexpected beneficial cardiovascular and reno-protective effects of this class of compounds...
April 17, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29663892/complement-components-c3-and-c4-and-the-metabolic-syndrome
#6
Melanie Copenhaver, Chack-Yung Yu, Robert P Hoffman
INTRODUCTION: Increased systemic inflammation is engaged likely plays a significant role in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. The complement system is part of the innate immune system and plays a key role in in regulation inflammation. Of particular importance is the activation of complement components C3 and C4. C3 is produced primarily by the liver but is also produced in adipocytes, macrophages and endothelial cells, all of which are present in adipose tissue...
April 17, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29618311/predicting-factors-affecting-glucose-monitoring-treatment-satisfaction-and-drug-attitude-inventory-adherence-among-patients-with-type-2-diabetes-mellitus-cross-sectional-observational-study
#7
Syed Ata Ur Rahman
OBJECTIVES: The study aimed to explore the predictors affecting patient satisfaction to glucose monitoring system (GMSS) and drug attitude inventory (DAI) / treatment adherence among type 2 diabetes mellitus patients. METHODS: Cross-sectional observational study design was used to conduct this study. Subjective assessments were made by questionnaires and objective data was collected from the patients' medication profiles registered to diabetic clinics. Patients were recruited from five different public hospitals of Hyderabad region, India...
April 4, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29623848/the-complications-of-bariatric-surgery-patients-with-type-2-diabetes-in-the-world-a-systematic-review-and-meta-analysis
#8
Ali Kabir, Sara Mousavi, Abdolreza Pazouki
BACKGROUND: In this Meta-analysis, we aimed to quantify the incidence of complications of different methods of bariatric surgery on diabetic patients. INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is increasing worldwide specifically in obese cases. Additionally, obesity worsens T2DM. Complications of each bariatric surgery method were assessed separately; but, meta-analysis of these complications and comparison between procedures in T2DM patients has not been investigated previously...
April 3, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29557753/hyperglycemic-hyperosmolar-state-a-pragmatic-approach-to-properly-manage-sodium-derangements
#9
Marco Baldrighi, Pier Paolo Sainaghi, Mattia Bellan, Ettore Bartoli, Luigi Mario Castello
INTRODUCTION: Although hypovolemia remains the most relevant problem during acute decompensated diabetes in its clinical manifestations (diabetic ketoacidosis, DKA, and hyperglycemic hyperosmolar state, HHS), the electrolyte derangements caused by the global hydroelectrolytic imbalance usually complicate the clinical picture at presentation and may be worsened by treatment itself. AIM: This review article is focused on the management of dysnatremias during hyperglycemic hyperosmolar state with the aim of providing clinicians a useful tool to early indentify the sodium derangement in order to address properly its treatment...
March 19, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29446746/mechanisms-involved-in-glycemic-control-promoted-by-exercise-in-diabetics
#10
Eric Francelino Andrade, Viviam de Oliveira Silva, Debora Ribeiro Orlando, Luciano Jose Pereira
Diabetes mellitus is a metabolic disease characterized by high glycemic levels for long periods. This disease has a high prevalence in the world population, being currently observed an increase in its incidence. This fact is mainly due to the sedentary lifestyle and hypercaloric diets. Non-pharmacological interventions for glycemic control include exercise, which promotes changes in skeletal muscle and adipocytes. Thus, increased glucose uptake by skeletal muscle and decreased insulin resistance through modulating adipocytes are the main factors that improve glycemic control against diabetes...
February 14, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29366422/prevalence-of-chronic-diabetic-complications-in-newly-diagnosed-versus-known-type-2-diabetic-subjects-in-a-sample-of-alexandria-population-egypt
#11
Samir Assaad Khalil, Magdy Helmy Megallaa, Kamel Hemida Rohoma, Myriam AbouSeif Guindy, Adel Zaki, Mohamed Hassanein, Amin Helmy Malaty, Hanaa Mohamed Ismael, Ibrahim Fahmy Kharboush, Dalal Nasr-Eldein El Kafash, Hassan Nooman Sallam, Iman Abdelkareem Desouky
BACKGROUND: In Egypt, data on the prevalence of chronic diabetic complications, which are essential for the adjustment of policies and practices related to diabetes care, are scarce. Therefore, the aim of this study was to determine the frequency of chronic complications of diabetes; namely neuropathy, diabetic kidney disease (DKD), retinopathy and peripheral arterial disease (PAD) in newly-diagnosed versus known type 2 diabetic patients. SUBJECTS & METHODS: This is a cross-sectional study that is based on a previous household survey conducted on a representative sample of the population of Alexandria, Egypt...
January 24, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29359675/consistency-of-toe-systolic-pressures-brachial-systolic-pressures-and-toe-brachial-indices-in-people-with-and-without-diabetes
#12
Robert Trevethan
BACKGROUND & AIMS: Toe systolic blood pressures (TSPs) and toe-brachial indices (TBIs) have been identified as useful adjuncts in the identification of pedal ischemia, peripheral artery occlusive diseases, and risk for either nonhealing of lower extremity wounds or for amputation. Valid measurement of TSPs and TBIs is therefore essential. However, it could be jeopardized by rater, instrument, and intratestee inconsistency. These three sources of inconsistency were examined in this research...
January 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29357808/the-role-of-oestrogen-receptor-beta-er%C3%AE-in-the-aetiology-and-treatment-of-type-2-diabetes-mellitus
#13
Wendy Amy Ofosu, Daahir Mohamed, Olivia Corcoran, Opeolu Oyejide Ojo
INTRODUCTION: Challenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target...
January 19, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29357807/hyperglycemia-in-hospitalized-diabetic-non-critically-ill-patients-prevalence-correlates-management-and-nurses-attitudes
#14
Ghada El Khoury, Hanine Mansour, Wissam Kabbara, Nibal Chamoun, Nadim Attalah, Pascale Salameh
BACKGROUND: Diabetes Mellitus is a chronic metabolic disease that affects 387 million people around the world. Episodes of hyperglycemia in hospitalized diabetic patients are associated with poor clinical outcomes and increased morbidity and mortality. Therefore, prevention of hyperglycemia is critical to, decrease length of hospital stay and to reduce complications and readmissions. OBJECTIVE: The study aims to examine the prevalence of hyperglycemia and assess the correlates and management of hyperglycemia in diabetic non-critically ill patients...
January 19, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29357806/correlation-between-white-blood-cell-count-and-insulin-resistance-in-type-2-diabetes
#15
Armin Mahdiani, Masoume Kheirandish, Shokoufeh Bonakdaran
BACKGROUND: The role of chronic inflammation in insulin resistance states and the pathogenesis of metabolic syndrome, cardiovascular disease and diabetes have been reported earlier. White blood cell (WBC) count is an easy marker for estimation of systemic inflammation. OBJECTIVE: This study is to clarify whether WBC count associate with insulin resistance in type 2 diabetic patients. METHOD: This cross sectional study was conducted in 283 patients with type 2 diabetes and in 283 healthy non diabetic subjects as control group...
January 19, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29332589/validation-of-an-arabic-version-of-the-obesity-related-wellbeing-orwell-97-questionnaire-in-adults-with-obesity
#16
Leila Itani, Simona Calugi, Dima Kreidieh, Germine El Kassas, Dana El Masri, Hana Tannir, Riccardo Dalle Grave, Aya Harfoush, Marwan El Ghoch
BACKGROUND: No specific questionnaire that evaluates Health-Related Quality Of Life (HRQOL) in individuals with obesity is available in the Arabic language. The aim of this study was therefore to propose and examine the validity and reliability of an Arabic language version of the ORWELL 97, a validated obesity-related HRQOL questionnaire. METHODS: The ORWELL 97 questionnaire was translated from English to Arabic language and administered to 318 Arabic-speaking participants (106 from clinical and 212 from community samples), and underwent internal consistency, test-retest reliability, construct and discriminative validity analysis...
January 10, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29284395/editorial-current-challenges-in-islet-transplantation-and-stem-cell-therapies-in-diabetes
#17
EDITORIAL
Miriam Ramirez-Dominguez
No abstract text is available yet for this article.
2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28595528/type-1-diabetes-treatments-based-on-stem-cells
#18
Miriam Arana, Anujith Kumar, Ashwini Ashwathnarayan, Maher Atari, Miguel Barajas
BACKGROUND: More than a decade ago, a new research field named Stem Cell Therapy emerged in Health Science. Initially, it was considered that cells owned a differentiation capability; however, this dogma has changed when new results have been published regarding the ability of the cells to differentiate into different cell tissue mainly due to the novel reprogramming strategies. Accordingly, cells from an adult tissue source may be potentially capable of originating cells of a very different cell type...
2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28474555/isolated-compounds-from-natural-products-with-potential-antidiabetic-activity-a-systematic-review
#19
Antonio C M Munhoz, Tania S Frode
BACKGROUND: Worldwide, Type 2 diabetes has become a growing health problem. While many research articles in the field of ethnopharmacology have focused on the antidiabetic properties of medicinal plant species, insufficient evidence remains regarding their therapeutic use. Studies using both in vitro and in vivo models are necessary to evaluate various medicinal plants species, used in folk medicine, by using scientific criteria. METHODS: This review focuses on isolated compounds from medicinal plant species that have reported antidiabetic activity in diabetes models...
2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27363412/stem-cell-based-therapies-for-improving-islet-transplantation-outcomes-in-type-1-diabetes
#20
Joao P M C M Cunha, Conny Gysemans, Pieter Gillard, Chantal Mathieu
INTRODUCTION: Beta-cell replacement by human islets or whole pancreas offers a life-saving therapeutic remedy for patients suffering from type 1 diabetes, providing considerable advantages with respect to diminishing total daily insulin dose and lowering frequencies of debilitating hypoglycemic reactions as well as preventing chronic micro- and macrovascular complications. Although remarkable progress has been made in this area, several hurdles remain, hampering its wide-spread applicability...
2018: Current Diabetes Reviews
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