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Current Diabetes Reviews

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https://www.readbyqxmd.com/read/30215336/lignans-potential-in-pre-and-post-onset-type-2-diabetes-management
#1
D E Barre, K A Mizier-Barre
INTRODUCTION: Type 2 diabetes (T2D) cases continue to rise dramatically despite efforts to get people to exercise and eat with a view to health and combatting the cluster of 7 issues (elevated waist circumference, hyperglycaemia, hypertension, dyslipidemia, pro-thrombotic state, increased oxidation (including low density lipoprotein (LDL)) and the pro-inflammatory state associated with pre- and post-onset T2D. BACKGROUND: There are numerous medications available to deal with these seven major issues...
September 13, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30207237/association-of-pparg-gene-polymorphisms-pro12ala-with-type-2-diabetes-mellitus-a-meta-analysis
#2
Junyan Li, Xiaohong Niu, JianBo Li, Qingzhong Wang
BACKGROUND: Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000. OBJECTIVE: To further validate the risk of Pro12Ala for T2DM disease based on the genetic data...
September 12, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30179137/is-there-a-role-for-sodium-orthovanadate-in-the-treatment-of-diabetes
#3
Anoop Kumar, Divya Rana
Background and Introduction: Diabetes is a metabolic disorder, whose incidences are increasing day by day. Various classes of anti-diabetic drugs are clinically approved by the Food and Drug Administration (FDA) for treatment of diabetes mellitus, but unfortunately, none of them is able to treat this condition. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more safe and effective anti-diabetic agents. Sodium orthovanadate is well known common laboratory agent used to preserve the protein tyrosyl phosphorylation state of the protein...
September 3, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30156163/concurrent-and-longitudinal-association-between-glycemic-control-and-self-reported-medication-adherence-among-type-2-diabetes-patients-at-a-tertiary-care-hospital-in-malaysia
#4
Mubashra Butt, Adliah Mhd Ali, Mohd Makmor Bakry
BACKGROUND: This study evaluated the association of self reported adherence with concurrent and subsequent glycemic control amongst type 2 diabetes patients at a tertiary care hospital in Malaysia. METHOD: Demographic and clinical variables were assessed at baseline, after three and six months in 73 type 2 diabetes patients. Regression analysis, using SPSS, evaluated the concurrent and longitudinal association of medication adherence and glycemic control. Potential confounders of variables were identified using bi-variate correlation analyses...
August 28, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30117398/potential-utility-of-self-report-measures-of-affect-to-optimise-exercise-adherence-in-people-with-type-2-diabetes
#5
Emily Cox, Shelley E Keating, Jeff S Coombes, Nicola W Burton
Exercise is essential for managing type 2 diabetes, however approximately only 40% of people with the condition meet guidelines. The aim of this review is to examine the evidence regarding the use self-report measures of affect to understand and predict exercise adherence. Self-reported affect has been successfully used to regulate exercise intensity, monitor training load, prevent injury, and predict future physical activity participation in otherwise healthy and some clinical populations. Specific recommendations are provided for research to explore the utility of self-report measures of affect to promote exercise adherence in people with type 2 diabetes...
August 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30117397/evaluation-of-risk-factors-associated-with-diabetic-foot-ulcers-in-saudi-arabia
#6
Mousab Yousef Al-Ayed, Mutasem Ababneh, Asirvatham Alwin Robert, Ahmed Salman, Abdulghani Al Saeed, Mohamed Abdulaziz Al Dawish
BACKGROUND AND AIMS: Considering that diabetic foot ulceration is one of the major health issues globally, we aimed to evaluate the risk factors associated with foot ulcers in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 81 T2DM patients (age range: 40-80 years) registered at the Diabetes Treatment Center, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia between April and September 2015 were included in this cross-sectional study after purposive selection and assigning of patient numbers...
August 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30101716/hormonal-metabolic-and-hemodynamic-adaptations-to-glycosuria-in-type-2-diabetes-patients-treated-with-sodium-glucose-co-transporter-inhibitors
#7
Eugenio Cersosimo, John M Miles
BACKGROUND & INTRODUCTION: The advent of the sodium-glucose cotransporter-2 inhibitors [SGLT-2i] provides an additional tool to combat diabetes and complications. The use of SGLT-2i leads to effective and durable glycemic control with important reductions in body weight/fat and blood pressure. These agents may delay beta-cell deterioration and improve tissue insulin sensitivity, which might slow the progression of the disease. METHODS & RESULTS: In response to glycosuria, a compensatory rise in endogenous glucose production, sustained by a decrease in plasma insulin with an increase in glucagon has been described...
August 13, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30081789/impaired-awareness-of-hypoglycaemia-in-insulin-treated-type-2-diabetes-mellitus
#8
Mohammad J Alkhatatbeh, Nedaa A Abdalqader, Mohammad A Y Alqudah
BACKGROUND: Patients with Type 2 Diabetes Mellitus (T2DM) may develop hypoglycemia as an adverse effect of insulin therapy. Hypoglycemia has dangerous consequences that result from neuroglycopenia and hypersecretion of counter-regulatory hormones. Patients who recognize early symptoms of hypoglycemia can initiate self-treatment and rectify the situation. Impaired awareness of hypoglycemia (IAH) predisposes patients to severe hypoglycemia and unconsciousness. OBJECTIVE: To assess prevalence of IAH, intensity of hypoglycaemic symptoms, frequency of severe hypoglycemia and factors associated with IAH in patients with insulin-treated T2DM...
August 6, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30073928/androgen-therapy-in-male-patients-suffering-from-type-2-diabetes-a-review-of-benefits-and-risks
#9
Mortaza F Hassanabad, Mohammad Fatehi
BACKGROUND: The current estimated numbers of patients with type 2 diabetes (T2D) is believed to be close to 10% of the whole populations of many geographical regions, causing serious concerns over the resulting elevated morbidity and mortality as well as the impact on health care systems around the world. In addition to negatively affecting quality of life, diabetes is associated with cardiovascular and cerebrovascular complications, indicating that appropriate drug therapy should not only deal with metabolic dysfunction, but also protect the vascular system, kidney function and skeletal muscle mass from the effects of the epigenetic changes induced by hyperglycaemia...
July 31, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30058496/studying-the-gut-microbiome-of-latin-america-and-hispanic-latino-populations-insight-into-obesity-and-diabetes-systematic-review
#10
Romero-Ibarguengoitia Maria Elena, Garcia-Dolagaray Gabriela, Gonzalez-Cantu Arnulfod, Caballero Augusto Enrique
Background People from Latin America (LA) and the Hispanic/Latino community living in the United States (LUS) exhibit a high prevalence of diabetes (DM) and obesity (OB). The gut microbiome (GM) is capable of altering energy regulation and glucose metabolism, but for the expression of these diseases a combination of multiple factors such as ethnicity, genetic and nutritional factors are required. A systematic research was conducted to understand if the prevalence of OB and/or DM has an interaction with the GM in LA and LUS...
July 30, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30058494/genetics-of-latent-autoimmune-diabetes-in-adults
#11
Mette Korre Andersen, Torben Hansen
Diabetes is a multifactorial disease, caused by a complex interplay between environmental and genetic risk factors. Genetic determinants of particularly type 1 diabetes (T1D) and type 2 diabetes (T2D) have been studied extensively, whereas well-powered studies of latent autoimmune diabetes in adults (LADA) are lacking. So far available studies support a clear genetic overlap between LADA and T1D, however, with smaller effect sizes of the T1D-risk variants in LADA as compared to T1D. A genetic overlap between LADA and T2D is less clear...
July 30, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30058495/type-1-diabetes-related-autoantibodies-in-different-forms-of-diabetes
#12
Elin Pettersen Sorgjerd
Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA) and the most recently Zinc transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent autoimmune diabetes in adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA...
July 29, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30047331/ketoacidosis-due-to-empagliflozin-a-paradigm-shift-case-report-and-review-of-literature
#13
Hernandez-Quiles Carlos, Nieves Ramirez-Duque, Domingo Acosta-Delgado
INTRODUCTION: Sodium-glucose cotransporter 2(SGLT2)-inhibitors are new antihyperglycemic agents that have shown a reduction in cardiovascular events in type 2 diabetes mellitus. Recent warnings have been developed about an increased risk of euglycemic and moderate hyperglycemic diabetic ketoacidosis with the use of SGLT2 inhibitors, but its real incidence is not available yet. CASE REPORT: We present a case of DKA with moderate hyperglycemia in a patient treated with metformin and empagliflozin...
July 25, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30039763/recent-updates-on-glucokinase-activators-and-glucokinase-regulatory-protein-disrupters-for-the-treatment-of-type-2-diabetes-mellitus
#14
Aditi Kaushik, Manish Kaushik
The impairment of glucose metabolism leads to hyperglycemia and type-2 diabetes mellitus. Glucokinase enzyme is the key regulator of glucose homeostasis that catalyzes the conversion of glucose to glucose-6-phosphate in liver and pancreatic cells. In hepatocytes, GK controls the glucose uptake and glycogen synthesis. The action of liver GK is controlled by glucokinase regulatory protein (GKRP) partially. In fasting conditions the GKRP binds with GK and inactivate it from carbohydrate metabolism and serve as new target for treatment of diabetes mellitus...
July 23, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30009712/a-form-of-autoimmune-diabetes-in-adults-named-lada-an-update-on-essential-features-and-controversies
#15
Valdemar Grill, Bjorn O Asvold
Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than "classical" type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive for LADA this form of diabetes displays phenotypic characteristics that distinguishes it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and life style factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity...
July 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30009711/lada-a-type-of-diabetes-in-its-own-right
#16
Valdemar Grill
Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than "classical" type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive for LADA this form of diabetes displays phenotypic characteristics that distinguishes it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and life style factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity...
July 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30009710/environmental-lifestyle-risk-factors-for-lada
#17
Sofia Carlsson
Background To prevent diabetes it is important to identify common, modifiable risk factors in the population. Such knowledge is extensive for type 2 diabetes but limited for autoimmune forms of diabetes. Objective This review aims at summarizing the limited literature on potential environmental (lifestyle) risk factors for LADA. Method A pubmed search identified 15 papers that estimated the risk of LADA in relation to lifestyle. These were based on data from two population-based studies; a Swedish case-control study or a Norwegian cohort-study...
July 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30009709/treatment-of-latent-autoimmune-diabetes-in-adults-what-is-best
#18
Ingrid K Hals
Latent autoimmune diabetes in adults (LADA), although formally classified as type 1 diabetes (T1D), very often (at least in Western countries) appear clinically with type 2 diabetes (T2D)-like features as overweight and insulin resistance. LADA patients do not need exogenous insulin at the time they are diagnosed with diabetes, but a large percentage will within a few years develop need for such treatment. The decline in beta cell function progresses much faster in LADA than in T2D, presumably because of the ongoing autoimmune assault in LADA, and therefore necessitates insulin therapy much earlier in LADA than in T2D...
July 16, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29992890/diabetes-discharge-planning-and-transitions-of-care-a-focused-review
#19
Robin L Black, Courtney Duval
BACKGROUND: Diabetes is a growing problem in the United States. Increasing hospital admissions for diabetes patients demonstrate the need for evidence based care of diabetes patients by inpatient providers, as well as the importance of continuity of care when transitioning patients from inpatient to outpatient providers. METHOD: A focused literature review of discharge planning and transitions of care in diabetes, conducted in PubMed is presented. Studies were selected for inclusion based on content focusing on transitions of care in diabetes, risk factors for readmission, impact of inpatient diabetes education on patient outcomes, and optimal medication management of diabetes during care transitions...
July 11, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29992891/type-2-diabetes-and-asthma-systematic-review
#20
L Rayner, A McGovern, B Creagh-Brown, C Woodmansey, S de Lusignan
Background and objective Obesity is an important contributor to the risk of both asthma and type 2 diabetes (T2DM). However, it has been suggested that T2DM and asthma are also independently associated. The aim of this systematic review was to synthesise the evidence for an independent relationship between T2DM and asthma. Methods MEDLINE and EMBASE were searched for studies reporting the relationship between asthma and T2DM in adults. Given a potential bidirectional relationship, articles relating to T2DM as a risk factor for asthma, and asthma as a risk factor for T2DM were examined separately...
July 10, 2018: Current Diabetes Reviews
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