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Current Diabetes Reviews

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https://www.readbyqxmd.com/read/28814245/benefits-of-sglt2-inhibitors-beyond-glycemic-control-a-focus-on-metabolic-cardiovascular-and-renal-outcomes
#1
Molly G Minze, Kayley Will, Brian T Terrell, Robin L Black, Brian K Irons
BACKGROUND: Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new pharmacotherapeutic class for the treatment of type 2 diabetes mellitus (T2DM). OBJECTIVE: To evaluate beneficial effects of the SGLT2 inhibitors on metabolic, cardiovascular, and renal outcomes. METHODS: A Pub-Med search (1966 to July 2017) was performed of published English articles using keywords sodium-glucose co-transporter 2 inhibitors, canagliflozin, dapagliflozin, and empagliflozin...
August 16, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28814244/history-prevalence-and-assessment-of-limited-joint-mobility-from-stiff-hand-syndrome-to-diabetic-foot-ulcer-prevention
#2
Piergiorgio Francia, Roberto Anichini, Giuseppe Seghieri, Alessandra De Bellis, Massimo Gulisano
INTRODUCTION: Diabetes mellitus (DM) is one of the most important global public health problems. Patients with DM may develop different dreaded complications during their lifetime, one of which is limited joint mobility (LJM). Joint abnormalities and LJM are problems that can arise at disease onset, and progressively worsen together with the disease. Because LJM shares causal factors with other chronic diabetes-induced complications, its study has been considered useful for monitoring the risk of developing other chronic complications due to DM such as vascular disease or diabetic foot...
August 16, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28748753/investigating-the-practices-of-patients-and-hospitals-in-treatment-of-diabetes-a-survey-questionnaire-for-arabic-speaking-countries
#3
Irfan Anjum Manarvi, Nader Mahr Matta, Abdulrahman Yassin
Diabetes is one of the most chronic diseases prevalent in Kingdom of Saudi Arabia. Its number of patients have increased in past few decades. Best efforts to provide world class treatments to patients through public and private hospitals are in hand. However, feedback of practices observed by patients and hospitals is not being achieved to assess the treatment efficacy. Absence of an elaborated questionnaire in Arabic language is a major hurdle to seek information from patients' due to their limited knowledge of English language in which most of the survey questionnaire exist in internationally published literature...
July 27, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28738763/an-evaluation-of-the-clinical-therapeutic-effect-of-lixisenatide-in-type-2-diabetes-patients-a-systematic-literature-review
#4
Arinze Nkemdirim Okere, Janele Montesdeoca, April Glasper, Vakaramoko Diaby
BACKGROUND: With cardiovascular disease accounting for approximately 50% of deaths in patients diagnosed with type 2 diabetes, it is pertinent to initiate anti-diabetic medications with cardiovascular benefits. This systematic clinical review critically examines the clinical therapeutic effect of lixisenatide. METHODS: Data were gathered from articles indexed in PubMed, Google Scholar and Medline from 2010 - 2017, with the following search terms, "lixisenatide" and "GLP-1 receptor agonist...
July 24, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28714382/low-prevalence-of-insulin-resistance-among-iranian-patients-with-chronic-hepatitis-c-virus-infection-a-case-control-study
#5
Kavous Eshraghian, Kamran B Lankarani, Mohammad Reza Fattahi, Atefeh Esmailnejad, Payam Peyman
BACKGROUND: Association between chronic hepatitis C virus (CHC) infection and type 2 diabetes mellitus has been challenging in recent decades. Despite of extensive research in this area, there is no general agreement on the direct effect of HCV infection on insulin resistance. PATIENTS AND METHODS: The study was performed in 52 CHC patients (mean age = 39.48) and 52 and sex‑matched healthy Iranian controls, referred to the Hepatitis Clinic, Department of Gastroenterohepatology, Shiraz University of medical sciences, Shiraz, Iran, from 2012 to 2015...
July 14, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28699482/non-diabetic-glucose-levels-and-cancer-mortality-a-literature-review
#6
Eiichi Kakehi, Kazuhiko Kotani, Takashi Nakamura, Taro Takeshima, Eiji Kajii
BACKGROUND: Although diabetes mellitus is a risk factor for cancer, the relationship of an increased glucose concentration at a non-diabetic glucose level with cancer mortality is yet to be determined. OBJECTIVE: To observe whether an increased glucose concentration and/or glucose intolerance at the non-diabetic glucose level can predict cancer mortality. METHODS: Population-based prospective cohort studies evaluating cancer mortality at the non-diabetic level (defined as fasting plasma glucose <7...
July 11, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28699483/physical-disability-and-diabetes-mellitus-qualitative-exploration-of-patients-perception-and-behavior
#7
Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul, Sherif Yahya Saad
BACKGROUND: Disability is a key indicator implicating both overall morbidity and success of public health efforts to compress the period of morbidity among geriatrics for the overall population. Disabilities are more prevalent among diabetics than among those without diabetes. OBJECTIVE: This study aimed to determine self-monitoring practices, awareness to dietary modifications and barriers to medication adherence among physically disabled type 2 diabetes mellitus patients...
July 10, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28677496/metabolic-syndrome-dyslipidemia-and-regulation-of-lipoprotein-metabolism
#8
Jahangir Iqbal, Ali Al Qarni, Abbas Hawwari, Ahmad F Al Ghanem, Ahmed Gasmelseed
INTRODUCTION: Metabolic syndrome is associated with increased risk for both type 2 diabetes and cardiovascular disease. Development of these pathologies is associated with the disorders of lipid and lipoprotein metabolism. Dyslipidemia leads to the overproduction of potentially atherogenic lipid and lipoproteins. Furthermore, there is a decrease in the levels of high-density lipoproteins and an increase in the levels of remnant and small dense LDL particles. CONCLUSION: In the current review, we have discussed the pathophysiology of lipoprotein biosynthesis and metabolism in the metabolic syndrome...
July 5, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28637407/oral-insulin-myth-or-reality
#9
Vikash Kumar, Ishwari Choudhry, Pooja Hurkat, Ashish Jain, Dharmendra Jain
BACKGROUND: Diabetes mellitus (DM) is a disorder of glucose metabolism marked by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and ketonaemia. DM is a major healthcare problems today and its treatment costs billions of dollars worldwide annually. The cases of diabetes have increased rapidly in recent years throughout the world. Currently, for management of type-1 diabetes mellitus (TIDM), multiple daily insulin (MDI) injections is the most popular treatment. Oral administration of insulin is the most suitable and attractive as compared to subcutaneous route but unfortunately cannot be utilized for the administration of peptides and proteins due to poor epithelial permeability and enzymatic degradation within the gastrointestinal tract...
June 21, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28637406/socioeconomic-status-the-missing-link-between-obesity-and-diabetes-mellitus
#10
Alexei Volaco, Ana Maria Cavalcanti, Roberto Pecoits Filho, Dalton Bertolim Précoma
BACKGROUND: Currently, there is an epidemic expansion of the obesity rates worldwide. The increasing number of obese individuals associated with the aging of population leads to increasing number of individuals with type 2 diabetes mellitus (T2DM) at the same rate. The traditional factors that link obesity to T2DM are related to genetics, hypercaloric diet, sedentary lifestyle, and stress. Individuals from lower socioeconomic status (SES) have restricted autonomy and opportunities that could lead to more stress and consequently increase in stress hormones, such as cortisol, catecholamines, glucagon, and growth hormone, which might ultimately change fat deposition, increasing visceral fat and increasing the risk of T2DM mellitus development...
June 21, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28625131/long-term-lifestyle-modification-programs-for-overweight-and-obesity-management-in-the-arab-states-systematic-review-and-meta-analysis
#11
Dima Khreidieh, Leila Itani, Germine El Kassas, Dana El Masri, Simona Calugi, Riccardo Dalle Grave, Marwan El Ghoch
BACKGROUND: Obesity is a growing health problem worldwide. It is associated with serious medical and psychosocial comorbidities that increase the risk of mortality. However, strong evidence confirms lifestyle-modification programs as the cornerstone treatment for excess weight and obesity. The aim of this systematic review was to assess the effectiveness of the lifestyle-modification programs for weight management delivered in Arabic-speaking countries. METHODS: The PubMed database was searched, and studies conducted in humans were identified and screened as per the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
June 18, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28618984/glycemic-variability-and-insulin-needs-in-patients-with-type-1-diabetes-mellitus-supplemented-with-vitamin-d-a-pilot-study-using-continuous-glucose-monitoring-system
#12
Karem Miléo Felício, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Thaís Pontes Arbage, Hana Andrade de Rider Brito, Amanda Soares Peixoto, Alana Ferreira de Oliveira, Fabricio de Souza Resende, Scarlatt Sousa Reis, Ana Regina Motta, Henrique da Costa Miranda, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, João Soares Felício
BACKGROUND: Recent studies suggest that glycemic variability could influence the risk of complications in type 1 diabetes mellitus (T1DM). There are no data about the action of vitamin D (VD) on glycemic variability. Our pilot study aims to evaluate glycemic variability and insulin needs in patients with T1DM supplemented with VD. METHODS: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks, according to the patient's baseline VD levels and underwent continuous glucose monitoring system...
June 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28606045/patient-impressions-of-possible-catastrophic-outcomes-after-diabetic-foot-ulceration
#13
Benjamin Vickers, Javier La Fontaine, Naohiro Shibuya, Daniel C Jupiter, Zachary Ashmore
BACKGROUND: Diabetes mellitus (DM) and its complications are well studied; patients with diabetes may suffer from neuropathy and vascular issues, and associated with these, lower extremity ulceration. Ulcers are often refractory to treatment, and can be difficult for both patients and clinicians to manage. Such complications may lead to amputations, which in turn are a risk factor for death. However, in certain situations amputation may be the only option available, and may be used as reconstructive surgery, restoring function...
June 12, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28595528/type-1-diabetes-treatments-based-on-stem-cells
#14
Miriam Araña, Anujith Kumar, Ashwini Ashwathnarayan, Maher Atari, Miguel Barajas
More than a decade ago, a new research field named Stem Cell Therapy emerged in Health Science. Initially, it was considered that cells owned a differentiation capability; however, this dogma has changed when new results have been published regarding the ability of the cells to differentiate into different cell tissue mainly due to the novel reprogramming strategies. Accordingly, cells from an adult tissue source may be potentially capable of originating cells of a very different cell type. The possibility of transplanting these cells into damaged organs has triggered many studies to understand the plasticity of stem cells...
June 9, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28571543/aspartame-should-individuals-with-type-ii-diabetes-be-taking-it
#15
Arbind Kumar Choudhary
BACKGROUND: Individuals with type II diabetes (T2D) have to manage blood glucose levels to sustain health and longevity. Artificial sweeteners (including aspartame) are suggested sugar alternatives for these individuals. The safety of aspartame in particular, has long been the centre of debate. Although it is such a controversial product, many clinicians recommend its use to T2D patients, during a controlled diet and as part of an intervention strategy. Aspartame is 200 times sweeter than sugar and has a negligible effect on blood glucose levels, and it is suggested for use so that T2D can control carbohydrate intake and blood glucose levels...
May 31, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28554309/serum-levels-of-vaspin-and-its-correlation-with-nitric-oxide-in-type-2-diabetic-patients-with-nephropathy
#16
Aynaz Mihanfar, Mohammad Rahmati-Yamchi, Ali Mota, Sima Abediazar, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
BACKGROUND: Diabetic nephropathy (DN), a serious and prevalent complication of diabetes, has been rapidly raising worldwide. Vaspin, as an adipokine with anti-diabetic effects, is predominantly released from visceral adipose tissue. Moreover, vaspin has the stimulatory effect on nitric oxide (NO) bioavailability through the activation of NO synthase. OBJECTIVE: The aim of the present study was to investigate serum levels of vaspin and their correlation with NO metabolite in diabetic patients with normal renal function and renal insufficiency...
May 29, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28530530/is-fish-oil-a-potential-treatment-for-diabetic-peripheral-neuropathy
#17
Mark Anthony Yorek
BACKGROUND: Peripheral neuropathy affects about 50% of the diabetic population. The manifestations range from pain, numbness, paresthesia and ulceration in the extremities and it is the major cause of non-traumatic amputations. Currently there is no effective treatment for peripheral neuropathy. With the prevalence of obesity and type 2 diabetes and associated complications reaching epidemic levels there is a critical need for finding a treatment to preserve nerve function. INTRODUCTION: This article will review the potential for fish oil as a treatment for diabetic peripheral neuropathy...
May 22, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28523995/alternative-therapies-for-diabetes-a-comparison-of-western-and-traditional-chinese-medicine-tcm-approaches
#18
Eric Xiao, Luguang Luo
BACKGROUND: Across the world, the economic and health costs of diabetes are rising at an alarming rate. Each year in the United States, billions of dollars are spent on T2 Diabetes mellitus (T2DM) treatments, but such treatments are not always effective and can lead to adverse events. Many pharmacological treatments exist to control the primary and secondary symptoms of T2DM, but these medications are not always efficacious, do little to treat secondary T2DM symptoms, and often carry adverse side effects...
May 18, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28523994/potential-biomolecules-and-current-treatment-technologies-for-diabetic-foot-ulcer-an-overview
#19
Zenith Khashim, Shila Samuel, Nallusamy Duraisamy, Kathiravan Krishnan
BACKGROUND: Diabetic foot ulceration remains a major challenge and is one of the most expensive and leading causes of major and minor amputations among patients with diabetic foot ulcer. Hence the purpose of this review is to emphasize on potential molecular markers involved in diabetic foot ulcer physiology, the efficacy of different types of dressing materials, adjunct therapy and newer therapeutic approach like nanoparticles for the treatment of diabetic foot ulcer. METHODS: We conducted a systematic literature review search by using Pubmed and other web searches...
May 18, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28474557/the-possible-hypoglycemic-mechanisms-of-echinochrome
#20
Ayman Saber Mohamed, Amel Mahmoud Soliman, Mohamed-Assem Said Marie
BACKGROUND: Diabetes mellitus is a main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments. OBJECTIVE: In our study, we tried to collect all the possible the hypoglycemic mechanism of echinochrome...
May 5, 2017: Current Diabetes Reviews
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