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Journal of Clinical Neurology

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https://www.readbyqxmd.com/read/29504299/neutralizing-antibodies-against-interferon-beta-in-korean-patients-with-multiple-sclerosis
#1
Jae Won Hyun, Gayoung Kim, Yeseul Kim, Byungsoo Kong, AeRan Joung, Na Young Park, Hyunmin Jang, Hyun June Shin, Su Hyun Kim, Suk Won Ahn, Ha Young Shin, So Young Huh, Woojun Kim, Min Su Park, Byung Jo Kim, Byoung Joon Kim, Jeeyoung Oh, Ho Jin Kim
BACKGROUND AND PURPOSE: Patients treated with interferon-beta (IFN-β) can develop neutralizing antibodies (NAbs) against IFN-β that can negatively affect the therapeutic response. This study assessed the prevalence of NAbs and the impact of NAb positivity on the therapeutic response to IFN-β in Korean patients with multiple sclerosis (MS). METHODS: This was a multicenter study involving 150 MS patients from 9 Korean medical centers who were treated with IFN-β for at least 6 months...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504298/swallowing-and-aspiration-risk-a-critical-review-of-non-instrumental-bedside-screening-tests
#2
REVIEW
Ioanna Eleni Virvidaki, Grigorios Nasios, Maria Kosmidou, Sotirios Giannopoulos, Haralampos Milionis
BACKGROUND AND PURPOSE: The presence of dysphagia and aspiration in stroke patients is associated with increased mortality and morbidity. Early recognition and management of these two conditions via reliable, minimally invasive bedside procedures before complications arise remains challenging in everyday clinical practice. This study reviews the available bedside screening tools for detecting swallowing status and aspiration risk in acute stroke by qualitatively observing reference population study design, clinical flexibility, reliability and applicability to acute-care settings...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504297/demographic-and-clinical-correlates-of-seizure-frequency-findings-from-the-managing-epilepsy-well-network-database
#3
Erdong Chen, Martha Sajatovic, Hongyan Liu, Ashley Bukach, Curtis Tatsuoka, Elisabeth Welter, Samantha S Schmidt, Yvan A Bamps, Shelley C Stoll, Tanya M Spruill, Daniel Friedman, Charles E Begley, Ross Shegog, Robert T Fraser, Erica K Johnson, Barbara C Jobst
BACKGROUND AND PURPOSE: Epilepsy is a chronic neurological disease that represents a tremendous burden on both patients and society in general. Studies have addressed how demographic variables, socioeconomic variables, and psychological comorbidity are related to the quality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on how these factors may differ between patients who exhibit varying degrees of seizure control. This study utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for Disease Control and Prevention with the aim of elucidating differences in demographic variables, depression, and QOL between adult PWE...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504296/medial-vowel-writing-difficulty-in-korean-syllabic-writing-a-characteristic-sign-of-alzheimer-s-disease
#4
Ji Hye Yoon, Yong Jeong, Duk L Na
BACKGROUND AND PURPOSE: Korean-speaking patients with a brain injury may show agraphia that differs from that of English-speaking patients due to the unique features of Hangul syllabic writing. Each grapheme in Hangul must be arranged from left to right and/or top to bottom within a square space to form a syllable, which requires greater visuospatial abilities than when writing the letters constituting an alphabetic writing system. Among the Hangul grapheme positions within a syllable, the position of a vowel is important because it determines the writing direction and the whole configuration in Korean syllabic writing...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504295/optical-coherence-tomography-versus-visual-evoked-potentials-for-detecting-visual-pathway-abnormalities-in-patients-with-neuromyelitis-optica-spectrum-disorder
#5
Nam Hee Kim, Ho Jin Kim, Cheol Yong Park, Kyoung Sook Jeong, Joong Yang Cho
BACKGROUND AND PURPOSE: Optical coherence tomography (OCT) and visual evoked potentials (VEPs) can be used to detect optic neuritis (ON). However, the comparative sensitivities of OCT and VEPs for detecting ON in neuromyelitis optica spectrum disorder (NMOSD) are unclear, and so we assessed these sensitivities. METHODS: This cross-sectional study included 73 patients with aquaporin-4 antibody-seropositive NMOSD, and 101 eyes with ON. The clinical characteristics, visual acuity (VA), Expanded Disability Status Scale (EDSS) scores, OCT peripapillary retinal nerve fiber layer (RNFL) thickness, and VEPs of the patients were evaluated...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504294/predictors-of-institutionalization-in-patients-with-alzheimer-s-disease-in-south-korea
#6
Dong Gyu Park, Soojin Lee, Young Min Moon, Duk L Na, Ji Hyang Jeong, Kyung Won Park, Yoon Hwan Lee, Tae Sung Lim, Seong Hye Choi, So Young Moon
BACKGROUND AND PURPOSE: We investigated predictors of institutionalization in patients with Alzheimer's disease (AD) in South Korea. METHODS: In total, 2,470 patients with AD aged 74.5±7.8 years (mean±standard deviation, 68.1% females) were enrolled from November 2005 to December 2013. The dates of institutionalization were identified from the public Long-Term-Care Insurance program in January 2014. We used a Cox proportional-hazards model to identify predictors for future institutionalization among characteristics at the time of diagnosis in 2,470 AD patients...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504293/electroencephalographic-abnormalities-in-the-screening-for-pilot-applicants-in-korea
#7
Dan A Oh, Hyeyun Kim, Eun Kee Bae
BACKGROUND AND PURPOSE: Electroencephalography (EEG) is often used as a screening tool for selecting pilots despite controversy regarding its contribution to aviation safety. We investigated EEG abnormalities in Korean commercial pilot applicants in order to identify the usefulness of EEG screening in this population. METHODS: We retrospectively analyzed the EEG results of 740 unselected pilot applicants who underwent waking EEG at Inha University Hospital from January 2013 to May 2017...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504292/current-clinical-applications-of-diffusion-tensor-imaging-in-neurological-disorders
#8
REVIEW
Woo Suk Tae, Byung Joo Ham, Sung Bom Pyun, Shin Hyuk Kang, Byung Jo Kim
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relatively new neuroimaging modality...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29504291/increased-risk-of-ischemic-stroke-during-sleep-in-apneic-patients
#9
Jin Soo Kim, Seongheon Kim, Seung Hwan Lee, Hee Young Lee, Seo Young Lee, Kyoung Bin Im
BACKGROUND AND PURPOSE: The literature indicates that obstructive sleep apnea (OSA) increases the risk of ischemic stroke. However, the causal relationship between OSA and ischemic stroke is not well established. This study examined whether preexisting OSA symptoms affect the onset of acute ischemic stroke. METHODS: We investigated consecutive patients who were admitted with acute ischemic stroke, using a standardized protocol including the Berlin Questionnaire on symptoms of OSA prior to stroke...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629536/coexistence-of-amyotrophic-lateral-sclerosis-in-the-proband-of-an-x-linked-charcot-marie-tooth-disease-type-1-pedigree-in-china
#10
LETTER
Shu Yan Feng, Shu Man Feng, Liu Yi Li, Zhang Yu Zou
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629535/is-corticospinal-tract-degeneration-caused-by-sj%C3%A3-gren-syndrome
#11
LETTER
Tai Seung Nam, Michael Levy, Sang Hoon Kim, Kyung Wook Kang, Byoung Joon Kim, Seung Han Lee
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629534/multiple-cranial-nerve-palsies-an-unusual-culprit
#12
LETTER
Turlapati Padmavathi Shashikala, Sahil Mehta, Aman Sharma, Bhagwant Rai Mittal
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629533/central-trochlear-palsy-as-an-isolated-finding-with-metastatic-tumor
#13
LETTER
Sun Uk Lee, Jeong Yoon Choi, Hyo Jung Kim, Ji Soo Kim
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629532/self-injurious-behavior-revealing-advanced-primary-progressive-multiple-sclerosis-with-a-massive-right-temporal-lesion
#14
LETTER
Markus Gschwind, Agustina Maria Lascano, Gürkan Kaya, Frederic Assal
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629531/pathogenic-variant-of-reep1-in-a-korean-family-with-autosomal-dominant-hereditary-spastic-paraplegia
#15
LETTER
Hyung Jun Park, Myung Jun Lee, Jee Eun Lee, Kee Duk Park, Young Chul Choi
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629530/paraneoplastic-neuromyelitis-optica-associated-with-lung-adenocarcinoma-in-a-young-woman
#16
LETTER
Kyoung Won Baik, Se Hoon Kim, Ha Young Shin
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629529/questioning-the-diagnosis-of-recurrent-optic-neuritis-associated-with-neuro-beh%C3%A3-et-s-disease
#17
LETTER
Soo Young Bae, Yong Wan Kim, Kyong Jin Shin
No abstract text is available yet for this article.
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629528/prevalence-of-multiple-sclerosis-in-a-turkish-city-bordering-an-iron-and-steel-factory
#18
Ülkü Türk Börü, Adnan Burak Bilgiç, Cansu Köseoğlu Toksoy, Abdullah Yasir Yılmaz, Mustafa Tasdemir, Nilay Padir Sensöz, Özgür Öztop Çakmak, Arda Duman, Cem Bölük
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination. Recent studies have shown that long-term exposure to air pollutants (including PM10 particulates) is potentially an environmental risk factor for MS. We aimed to determine the prevalence rates of MS in two cities with different levels of air pollution. METHODS: This door-to-door population-based study was conducted between April 2014 and June 2015...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629527/an-8-week-low-intensity-progressive-cycling-training-improves-motor-functions-in-patients-with-early-stage-parkinson-s-disease
#19
Hsiu Chen Chang, Chin Song Lu, Wei Da Chiou, Chiung Chu Chen, Yi Hsin Weng, Ya Ju Chang
BACKGROUND AND PURPOSE: The effects of high-intensity cycling as an adjuvant therapy for early-stage Parkinson's disease (PD) were highlighted recently. However, patients experience difficulties in maintaining these cycling training programs. The present study investigated the efficacy of cycling at a mild-to-moderate intensity in early-stage PD. METHODS: Thirteen PD patients were enrolled for 16 serial cycling sessions over a 2-month period. Motor function was assessed using the Unified Parkinson's Disease Rating Scale part III (UPDRS III) and Timed Up and Go (TUG) test as primary outcomes...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29629526/underregistration-and-underreporting-of-stem-cell-clinical-trials-in-neurological-disorders
#20
Timothy E Lee, Aryun Kim, Mihee Jang, Beomseok Jeon
BACKGROUND AND PURPOSE: Research on stem cells (SC) is growing rapidly in neurology, but clinical applications of SC for neurological disorders remain to be proven effective and safe. Human clinical trials need to be registered in registries in order to reduce publication bias and selective reporting. METHODS: We searched three databases-clinicaltrials.gov, the Clinical Research Information System (CRIS), and PubMed-for neurologically relevant SC-based human trials and articles in Korea...
April 2018: Journal of Clinical Neurology
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