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Diagnostic Pathology

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https://www.readbyqxmd.com/read/29759085/telepathology-consultation-for-frozen-section-diagnosis-in-china
#1
Yingxin Huang, Yan Lei, Qi Wang, Dazhou Li, Lili Ma, Lili Guo, Minshan Tang, Guanglong Liu, Qianwen Yan, Lan Shen, Guihui Tong, Zhiliang Jing, Yan Zhang, Yongjian Deng
BACKGROUND: Telepathology (TP) provides remote pathology services for primary diagnosis practices, including intraoperative consultation of surgical pathology; it has not been widely implemented in China. In this study, the results of an implementation were reported, which lasted for two and a half years, and demonstrated the experience of the diagnosis of the intraoperative frozen sections by using TP consultation platform of Southern Medical University and Guangzhou Huayin Medical Laboratory Center (SMU-HUAYIN TP) in China...
May 14, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29747695/a-case-report-of-granulomatous-amoebic-encephalitis-by-group-1-acanthamoeba-genotype-t18-diagnosed-by-the-combination-of-morphological-examination-and-genetic-analysis
#2
Takahiro Matsui, Tetsuo Maeda, Shinsuke Kusakabe, Hideyuki Arita, Kenji Yagita, Eiichi Morii, Yuzuru Kanakura
BACKGROUND: The diagnosis of granulomatous amoebic encephalitis is challenging for clinicians because it is a rare and lethal disease. Previous reports have indicated that Acanthamoeba with some specific genotypes tend to cause the majority of human infections. We report a case of granulomatous amoebic encephalitis caused by Acanthamoeba spp. with genotype T18 in an immunodeficient patient in Japan after allogenic bone marrow transplantation, along with the morphological characteristics and genetic analysis...
May 10, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29747676/epithelioid-cell-histiocytoma-with-sqstm1-alk-fusion-a-case-report
#3
Ryuko Nakayama, Yuki Togashi, Satoko Baba, Yo Kaku, Yuki Teramoto, Takaki Sakurai, Hironori Haga, Kengo Takeuchi
BACKGROUND: Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK protein expression and/or ALK gene rearrangement in ECH suggests that it might be biologically different from conventional FH. CASE PRESENTATION: A 27-year-old male presented with nodule on his left foot, which had been present for 5 years. A macroscopic examination revealed an exophytic, hyperkeratotic nodule on the dorsum of the left foot...
May 10, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29720207/the-t-14-18-translocation-is-absent-from-endothelial-and-follicular-dendritic-cells-of-follicular-lymphoma-fl-and-shows-heterogeneous-presence-in-preserved-fl-mantle-zones
#4
Perikles Kosmidis, Barbara Mankel, Falko Fend, Patrick Adam
BACKGROUND: The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85-90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be observed in other cell types of the microenvironment remains debated. Of interest, cases of associated histiocytic and dendritic cell sarcomas arising in the background of FL have been shown to be clonally related and carry the t(14;18), suggesting a "transdifferentiation" of the malignant FL clone into a neoplasm of a different hematopoietic lineage...
May 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29720204/retraction-note-the-microrna-325-inhibits-hepatocellular-carcinoma-progression-by-targeting-high-mobility-group-box-1
#5
Huifen Li, Weihua Huang, Rongcheng Luo
The editor has retracted this article [1] because it shows significant overlap with the following articles (amongst others) [2, 3]. None of the authors responded to correspondence regarding this retraction.
May 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29703236/high-grade-serous-carcinoma-with-discordant-p53-signature-report-of-a-case-with-new-insight-regarding-high-grade-serous-carcinogenesis
#6
Yuichiro Hatano, Shinya Fukuda, Hiroshi Makino, Hiroyuki Tomita, Ken-Ichirou Morishige, Akira Hara
BACKGROUND: Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-grade serous carcinoma (HGSC) patients still remains unclear. CASE PRESENTATION: A 56-year-old woman was referred to the gynecologist on account of abdominal distention. Since radiological and serological workup suggested that her illness was due to advanced ovarian cancer (FIGO Stage IVB), she received neoadjuvant chemotherapy, and the clinical evaluation of the chemotherapeutic response was a partial response...
April 27, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29615085/expression-patterns-of-stat3-erk-and-estrogen-receptor-%C3%AE-are-associated-with-development-and-histologic-severity-of-hepatic-steatosis-a-retrospective-study
#7
Euno Choi, Won Kim, Sae Kyung Joo, Sunyoung Park, Jeong Hwan Park, Yun Kyung Kang, So-Young Jin, Mee Soo Chang
BACKGROUND: Hepatic steatosis renders hepatocytes vulnerable to injury, resulting in the progression of preexisting liver disease. Previous animal and cell culture studies implicated mammalian target of rapamycin (mTOR), signal transducer and activator of transcription-3 (STAT3), extracellular signal-regulated kinase (ERK) and estrogen-receptor α in the pathogenesis of hepatic steatosis and disease progression. However, to date there have been few studies performed using human liver tissue to study hepatic steatosis...
April 3, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29606134/tgr5-expression-in-normal-kidney-and-renal-neoplasms
#8
Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang, Weibiao Cao
BACKGROUND: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker...
April 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29587781/ossifying-fibromyxoid-tumor-of-soft-parts-in-head-and-neck-case-report-and-literature-review
#9
Ignacio A Velasco, Ran Zhang, Tiejun Li, Diancan Wang
BACKGROUND: Ossifying fibromyxoid tumor of soft parts (OFMT), is a rare but morphologically distinctive neoplasm of uncertain histogenesis that most frequently affects middle-aged male adults. Clinically, it usually presents as a slowly enlarging, small, circumscribed mass, which in most cases is painless. OFMT is most frequently found within the subcutaneous tissues of extremities or trunk, and rarely in the oral/head and neck region. We present an unusual case of this tumor in the submandibular region, and, based on the current medical literatures this is probably the first case described in this anatomical location...
March 27, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29558947/does-heterogeneity-matter-in-the-estimation-of-tumour-budding-and-tumour-stroma-ratio-in-colon-cancer
#10
Ann C Eriksen, Johnnie B Andersen, Jan Lindebjerg, René dePont Christensen, Torben F Hansen, Sanne Kjær-Frifeldt, Flemming B Sørensen
BACKGROUND: Tumour budding (TB) and Tumour Stroma Ratio (TSR) may be rewarding in the treatment stratification of patients with stage II colon cancer. However, lack of standardization may exclude these parameters from being used in a clinical setting. The purpose of this methodologic study was to compare stereology with semi-quantitative estimations of TSR, to investigate the intra-tumoural heterogeneity of TB and TSR, and to assess the intra- and inter-observer agreement. METHODS: Three paraffin embedded tumour blocks, one of them representing the deepest invasive front, were selected from each of 43 patients treated for stage II colon cancer...
March 20, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29530054/physical-basis-of-the-magnification-rule-for-standardized-immunohistochemical-scoring-of-her2-in-breast-and-gastric-cancer
#11
Andreas H Scheel, Frédérique Penault-Llorca, Wedad Hanna, Gustavo Baretton, Peter Middel, Judith Burchhardt, Manfred Hofmann, Bharat Jasani, Josef Rüschoff
BACKGROUND: Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the most common screening test, thus precise and reproducible IHC-scoring is of utmost importance. Interobserver variance still is a problem; in particular in gastric carcinomas the reliable differentiation of IHC scores 2+ and 1+ is challenging. Herein we describe the physical basis of what we called the 'magnification rule': Different microscope objectives are employed to reproducibly subdivide the continuous spectrum of IHC staining intensities into distinct categories (1+, 2+, 3+)...
March 12, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29499721/novel-t-1-2-p36-1-q23-and-t-7-19-q32-q13-3-chromosomal-translocations-in-ischemic-fasciitis-expanding-the-spectrum-of-pseudosarcomatous-lesions-with-clonal-pathogenetic-link
#12
Taha Sachak, Nyla A Heerema, Joel Mayerson, Jason E Payne, Anil Parwani, O Hans Iwenofu
BACKGROUND: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events. CASE PRESENTATION: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago...
March 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29482573/clinicopathological-features-and-ebv-infection-status-of-lymphoma-in-children-and-adolescents-in-south-china-a-retrospective-study-of-662-cases
#13
Changfei Qin, Yuhua Huang, Yanfen Feng, Min Li, Na Guo, Huilan Rao
BACKGROUND: The clinicopathological features and Epstein-Barr virus (EBV) infection status of lymphoma in children and adolescents in South China is under-researched. South China is a well-known high-incidence area of EBV-associated nasopharyngeal carcinoma. METHODS: A cohort of 662 consecutive children and adolescents' lymphomas was retrospectively analyzed and Epstein-Barr virus encoded RNAs (EBERs) in situ hybridization was performed to detect the EBV infection...
February 27, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29463311/myeloid-transformation-of-plasma-cell-myeloma-molecular-evidence-of-clonal-evolution-revealed-by-next-generation-sequencing
#14
Jonathon H Gralewski, Ginell R Post, Frits van Rhee, Youzhong Yuan
BACKGROUND: Plasma cell myeloma (PCM) is a neoplasm of terminally differentiated B lymphocytes with molecular heterogeneity. Although therapy-related myeloid neoplasms are common in plasma cell myeloma patients after chemotherapy, transdifferentiation of plasma cell myeloma into myeloid neoplasms has not been reported in literature. Here we report a very rare case of myeloid neoplasm transformed from plasma cell myeloma. CASE PRESENTATION: A 60-year-old man with a history of plasma cell myeloma with IGH-MAF gene rearrangement and RAS/RAF mutations developed multiple soft tissue lesions one year following melphalan-based chemotherapy and autologous stem cell transplant...
February 20, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29463272/colonic-perineurioma-benign-fibroblastic-polyp-case-report-and-review-of-the-literature
#15
Abraham Christoffel van Wyk, Hennie van Zyl, Jonathan Rigby
BACKGROUND: Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic architecture. The vast majority of cases arise distal to the splenic flexure and have been described as sessile polyps. Using molecular analysis, BRAF mutations have been demonstrated in the serrated crypt epithelium. We report a new case of perineurioma presenting as a pedunculated polyp in the transverse colon, with prominent hemosiderin deposits in the uninvolved lamina propria that separated the perineurial proliferation from the surface epithelium, a previously unreported histological finding...
February 20, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29458385/de-novo-mast-cell-leukemia-without-cd25-expression-and-kit-mutations-a-rare-case-report-in-a-13-year-old-child
#16
Yalin Zheng, Lin Nong, Li Liang, Wei Wang, Ting Li
BACKGROUND: Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemic infiltrating of atypical mast cells (MCs) in bone marrow (BM), peripheral blood as well as extracutaneous organs. MCL is a fatal disease that almost always behaves aggressively, and the median survival time is only about six months. Herein, we present a rare case of de novo MCL without CD25 expression and KIT mutations...
February 20, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29433548/analytic-validity-of-decisiondx-melanoma-a-gene-expression-profile-test-for-determining-metastatic-risk-in-melanoma-patients
#17
Robert W Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R Covington, Kristen Oelschlager, Federico A Monzon, John F Stone
BACKGROUND: The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients into a low- (Class 1) or high-risk (Class 2) category for recurrence based on expression of 31 genes. The current study was designed to assess the analytical validity of this test. METHODS: Inter-assay, inter-instrument, and inter-operator studies were performed to evaluate reliability of the 31-gene expression test results, sample stability and reagent stability...
February 13, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29426340/pd-l1-diagnostic-tests-a-systematic-literature-review-of-scoring-algorithms-and-test-validation-metrics
#18
REVIEW
Margarita Udall, Maria Rizzo, Juliet Kenny, Jim Doherty, SueAnn Dahm, Paul Robbins, Eric Faulkner
BACKGROUND: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer. However, this new therapeutic approach requires reliable methods for identifying patients whose cancers are particularly likely to respond...
February 9, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29402318/differences-in-the-expression-profiles-of-claudin-proteins-in-human-nasopharyngeal-carcinoma-compared-with-non-neoplastic-mucosa
#19
Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao, Tao Li
BACKGROUND: Several studies have suggested that claudin proteins, which are the main components of tight junction structures, are related to the regulation of cell polarity and cell differentiation. METHOD: To explore the expression profiles of the tight junction proteins claudin-2, - 5, - 8 and - 9 in nasopharyngeal carcinoma, IHC (immunohistochemical analysis), Western blot and real-time PCR were used to detect the expression profiles of these claudin proteins in nasopharyngeal carcinoma tissues and in non-neoplastic mucosal tissues...
February 5, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29370815/breast-implant-associated-anaplastic-large-cell-lymphoma-in-a-li-fraumeni-patient-a-case-report
#20
Ricardo Garcia Pastorello, Felipe D'Almeida Costa, Cynthia A B T Osório, Fabiana B A Makdissi, Stephania Martins Bezerra, Marina de Brot, Antonio Hugo J F M Campos, Fernando Augusto Soares, José Vassallo
BACKGROUND: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been published on this entity in recent years, a great number of patients and health professionals remain unaware of this diagnosis. CASE PRESENTATION: We herein report the case of a 56-year-old female with Li-FRAUMENI syndrome who presented with late right-sided recurrent breast swelling after prophylactic adenomastectomy with implant reconstruction...
January 25, 2018: Diagnostic Pathology
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