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EuroIntervention

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https://www.readbyqxmd.com/read/27890863/the-first-clinical-experience-with-a-novel-locking-microcatheter-in-chronic-coronary-total-occlusions
#1
Simon J Wilson, Joren Maeremans, Simon J Walsh, Colm G Hanratty, Markus Meyer-Gessner, Jo Dens, Evald H Christiansen, Alexander Bufe, James C Spratt
AIMS: A novel 'locking' microcatheter has been developed to address residual failure modes in chronic total occlusion (CTO) percutaneous coronary intervention (PCI). The aim of this study was to report the first clinical experience of this device. METHODS AND RESULTS: The microcatheter was assessed prospectively in 92 unselected CTO cases across 6 European sites. Overall technical success was 85.9% (79/92) and 97.5% for patients with a J- CTO score of <3 (39/40)...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890862/randomized-blinded-and-controlled-comparative-study-of-chemical-and-radiofrequency-based-renal-denervation-in-a-porcine-model
#2
Stefan Bertog, Tim A Fischell, Félix Vega, Vartan Ghazarossian, Atul Pathak, Laura Vaskelyte, Darrin Kent, Horst Sievert, Elena Ladich, Kazuyuki Yahagi, Renu Virmani
AIMS: The blood pressure lowering effect of percutaneous renal denervation (RDN) is controversial. Success of RDN may be device-dependent. We sought to compare the efficacy of RDN by chemical neurolysis using alcohol (Peregrine System™ Infusion Catheter, Ablative Solutions, Inc. Menlo Park, CA, USA) to RDN by radiofrequency (RF) ablation with the single-electrode RF catheter (Symplicity™ Flex, Medtronic Inc., Minneapolis, MN, USA) in a porcine model. METHODS AND RESULTS: This was a prospective, randomized, blinded study...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890861/computed-tomography-angiography-planning-identifies-the-target-vessel-for-optimum-infarct-location-and-improves-clinical-outcome-in-alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#3
Robert Michael Cooper, Sukumaran Rajeswari Binukrishnan, Adeel Shahzad, Jonathan Hasleton, Ulrich Sigwart, Rodney Hilton Stables
AIMS: Alcohol septal ablation (ASA) is an established treatment option in HOCM. ASA is ineffective in some: inaccurate infarct and inability to identify a vessel contribute. We aimed to improve accuracy of infarct using CT angiography guidance and provide a more predictable and satisfactory outcome. METHODS AND RESULTS: Twenty-one successive patients with symptomatic LVOT obstruction refractory to medication underwent CT angiography planning to guide ASA. CT was performed using a dual source CT system...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890860/renal-denervation-by-ct-guided-periarterial-injection-of-hyperosmolar-saline-vincristine-paclitaxel-and-guanethidine-in-a-pig-model
#4
Patrick Freyhardt, Ricardo Donners, Alex Riemert, Jörg Schnorr, Nicola Stolzenburg, Jan Leo Rinnenthal, Ulrich Bernhardt, Bernd Hamm, Rolf W Günther, Florian Streitparth
AIMS: To evaluate feasibility, safety and efficacy of renal sympathetic denervation with CT- guided periarterial injection of potentially neurolytic agents in pigs. METHODS AND RESULTS: Unilateral injection of formulations containing either 5 M hyperosmolar saline, vincristine, paclitaxel or guanethidine around the renal artery was performed in 24 normotensive pigs with 6 animals per group. Needle placement and injections were performed under CT-fluoroscopy guidance...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890859/long-term-outcome-of-patients-with-chronic-total-coronary-occlusion-treated-by-percutaneous-coronary-intervention-in-diabetics-and-non-diabetics
#5
Francesca Sanguineti, Philippe Garot, Stephen O'Connor, Yusuke Watanabe, Marco Spaziano, Thierry Lefèvre, Thomas Hovasse, Hakim Benamer, Thierry Unterseeh, Bernard Chevalier, Marie Claude Morice, Yves Louvard
AIMS: Despite technical advancements, long-term outcomes after Chronic Total Occlusion (CTO) recanalization remain a subject of debate, especially in diabetic patients. METHODS AND RESULTS: Between 2004 and 2012, 1,320 consecutive patients underwent PCI for CTO, 27.4 % (362/1320) of whom were diabetics. We compared cardiac death, target lesion revascularisation (TLR), myocardial infarction (MI) and combined Myocardial Adverse Cardiac Events (MACE) in patients with successful versus failed PCI (median follow up 4...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890858/predictors-and-outcome-of-acute-kidney-injury-after-transcatheter-aortic-valve-implantation-a-systematic-review-and-meta-analysis
#6
Yan-Biao Liao, Xue-Xue Deng, Yang Meng, Zhen-Gang Zhao, Tian-Yuan Xiong, Xiang-Jun Meng, Zhi-Liang Zuo, Yi-Jian Li, Jia-Yu Cao, Yuan-Ning Xu, Mao Chen, Yuan Feng
AIMS: To investigate the predictors and outcome of acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: There were 35 articles recruiting 13,256 patients included in our study. Hypertension (odds ratio [OR], 1.92, 95% CI, 1.44 to 2.56), diabetes mellitus (OR, 1.33, 95% CI, 1.20 to 1.47), peripheral artery disease (OR, 1.28, 95% CI, 1.14 to 1.45), and a left ventricular ejection fraction <40% (OR, 1.50, 95% CI, 1...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867143/survival-after-percutaneous-coronary-intervention-for-chronic-total-occlusion-in-elderly-patients
#7
Aurel Toma, Catherine Gebhard, Michael Gick, Ademaj Fadil, Barbara E Stähli, Kambis Mashayekhi, Miroslaw Ferenc, Franz-Josef Neumann, Heinz Joachim Buettner
AIMS: Few data are available on outcomes of percutaneous coronary intervention (PCI) for coronary chronic total occlusions (CTO) in very elderly patients in the drug-eluting stent (DES) era. We investigated long-term survival in a single-center cohort of elderly patients following CTO PCI using DES. METHODS AND RESULTS: Consecutive 2002 patients who underwent PCI of a CTO at our center between 01/2005 and 12/2013 were followed for a median of 2.6 years (interquartile range 1...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867142/impact-of-plaque-type-and-side-branch-geometry-on-side-branch-compromise-after-provisional-stent-implantation-a-simulation-study
#8
Francesco Iannaccone, Claudio Chiastra, Antonios Karanasos, Francesco Migliavacca, Frank J H Gijsen, Patrick Segers, Peter Mortier, Benedict Verhegghe, Gabriele Dubini, Matthieu De Beule, Evelyn Regar, Jolanda J Wentzel
AIMS: Mechanisms of lumen compromise after provisional side-branch (SB) stenting are poorly understood. In this study we investigated the impact of bifurcation angle, plaque composition, and procedural strategy on SB compromise. METHODS AND RESULTS: Computer simulations of stent implantation were performed in Medina (1,1,1) bifurcation models. Provisional SB stenting was replicated including post-dilation after main branch stenting. Two bifurcation angles (45°,70°) and four plaque types (fully lipid, fully fibrous, lipid with half and full calcified ring distal to the carina) were tested...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867141/sex-differences-in-plaque-characteristics-by-intravascular-imaging-in-patients-with-coronary-artery-disease
#9
Monique E Ten Haaf, Melissa Rijndertse, Jin M Cheng, Sanneke P de Boer, Hector M Garcia Garcia, Robert-Jan M van Geuns, Evelyn Regar, Mattie J Lenzen, Yolande Appelman, Eric Boersma
AIMS: We aimed to study sex differences in coronary plaque burden and plaque composition in patients with coronary artery disease (CAD). METHODS AND RESULTS: Virtual histology intravascular ultrasound (VH-IVUS) and near-infrared spectroscopy (NIRS) imaging of a non-culprit coronary artery was performed in 178 (23.5%) women and 581 men who underwent invasive management of stable angina pectoris (SAP) or acute coronary syndrome (ACS). Women were older and had a worse cardiovascular risk profile than men, but less extended angiographic coronary disease...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867140/impact-of-calcified-bifurcation-lesions-in-patients-undergoing-percutaneous-coronary-intervention-using-drug-eluting-stents-results-from-the-coronary-bifurcation-stent-cobis-ii-registry
#10
Min Chul Kim, Youngkeun Ahn, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Hyeon-Cheol Gwon, Hyo-Soo Kim, Seung Woon Rha, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Ki Bae Seun
AIMS: Few data regarding clinical outcomes according to severity of calcification in patients with coronary bifurcation target lesions are available. METHODS AND RESULTS: This prospective, multicenter, observational registry enrolled 2,897 patients undergoing percutaneous coronary intervention with drug-eluting stents for coronary bifurcation lesions. We compared target lesion failure (TLF), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target lesion revascularization (TLR), according to severity of calcification in coronary bifurcation target lesions, assessed by an angiographic core laboratory using quantitative coronary angiography...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867139/in-vivo-validation-of-mathematically-derived-fractional-flow-reserve-for-assessing-hemodynamics-of-coronary-tandem-lesions
#11
Jihoon Kweon, Young-Hak Kim, Dong Hyun Yang, June-Goo Lee, Jae-Hyung Roh, Gary S Mintz, Seung-Whan Lee, Seong-Wook Park
AIMS: To propose a prediction model for the post-stenting fractional flow reserve (FFR'd,pred) at a position distal to the tandem lesion. METHODS AND RESULTS: Using the FFR at a position proximal to the tandem lesion (FFRp), the FFR gradients across proximal (ΔFFRp) and distal (ΔFFRd) stenoses, FFR'd,pred after treating either the distal or proximal lesion was predicted as FFRp-ΔFFRp/(1-1.33kΔFFRd) or FFRp- ΔFFRd/(1-1.33ΔFFRp), respectively. The flow fraction of the distal main branch (k) was estimated using the diameter ratio of side to distal main branches...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27867138/are-amplatzer-duct-occluder-ii-additional-sizes-devices-dedicated-for-only-smaller-children
#12
Roland Fiszer, Maciej Chojnicki, Małgorzata Szkutnik, Ireneusz Haponiuk, Beata Chodór, Jacek Białkowski
AIMS: To present our experience with the Amplatzer Duct Occluder Type II Additional Sizes (ADOIIAS) for the closure of different types of the patent ductus arteriosus (PDA) in patients of various age groups. METHODS AND RESULTS: A group of 103 patients were analyzed, in whom the PDA (diameter below 3,5 mm) was closed using the ADOIIAS. The median age of treated patients was 3,0 years (from 0,1 until 24 years), and 55 patients (53,4%) were older than 3 years. Ductal anatomy defined by angiography showed type A in 42 patients (40,8%), type C in 6 patients (5,8%), type D in 21 patients (20,5%), and type E in 34 patients (33,0%)...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840327/intravascular-ultrasound-guidance-improves-clinical-outcomes-during-implantation-of-both-first-and-second-generation-drug-eluting-stents-a-meta-analysis
#13
Nitesh Nerlekar, Caitlin J Cheshire, Kunal P Verma, Abdul-Rahman Ihdayhid, Liam M McCormick, James D Cameron, Martin R Bennett, Yuvaraj Malaiapan, Ian T Meredith, Adam J Brown
OBJECTIVE: To assess whether intravascular ultrasound (IVUS) improves clinical outcomes during implantation of first- and second-generation drug-eluting stents (DES). BACKGROUND: IVUS-guidance is associated with improved clinical outcomes during DES implantation, but it is unknown whether this benefit is limited to either first- or second-generation devices. METHODS: MEDLINE, EMBASE and PubMed were searched for studies comparing outcomes between IVUS- and angiography-guided PCI...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840326/safety-and-efficacy-of-a-bioabsorbable-polymer-coated-everolimus-eluting-coronary-stent-in-patients-with-diabetes-the-evolve-ii-diabetes-substudy
#14
Dean J Kereiakes, Ian T Meredith, Monica Masotti, Didier Carrié, Raul Moreno, Andrejs Erglis, Shamir R Mehta, Simon Elhadad, Jacques Berland, Bernardo Stein, Juhani Airaksinen, R Lee Jobe, Arthur Reitman, Luc Janssens, Thomas Christen, Keith D Dawkins, Stephan Windecker
AIMS: Bioabsorbable-polymer drug-eluting stents (DES) may reduce inflammation and delayed healing associated with some permanent polymer-coated DES. Whether late clinical outcomes are improved, particularly among patients with medically-treated diabetes, is unknown. METHODS AND RESULTS: SYNERGY is a thin-strut, platinum chromium everolimus-eluting stent with an ultrathin bioabsorbable poly (DL-lactide-co-glycolide) abluminal polymer. The EVOLVE II randomized, controlled trial proved noninferiority of SYNERGY versus the PROMUS Element Plus stent for 1-year target lesion failure (TLF: ischemia- driven target lesion revascularization [ID-TLR], target-vessel myocardial infarction [TVMI], or cardiac death)...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840325/quantitative-myocardial-blush-grade-reserve-during-pharmacologic-hyperemia-a-way-to-perform-a-real-wireless-fractional-flow-reserve-in-patients-with-coronary-artery-disease-and-intermediate-coronary-lesions
#15
Nina P Hofmann, Stefan Hardt, Markus Erbacher, Hartmut Dickhaus, Hugo A Katus, Grigorios Korosoglou
AIMS: We investigated the relation between myocardial blush grade reserve (MBGreserve) and fractional flow reserve (FFR) measures. FFR is a marker of inducible myocardial ischemia, which could guide percutaneous coronary intervention (PCI) and stent placement. However, it requires a pressure wire and is associated with additional costs and potential hazards. METHODS AND RESULTS: 56 patients who underwent routine cardiac catheterization for known or suspected coronary artery disease (CAD) and clinically indicated FFR measures in at least one coronary vessel were analyzed...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840324/suprasternal-brachiocephalic-approach-as-an-alternative-route-for-transcatheter-aortic-valve-implantation-a-single-center-experience
#16
Giuliana Capretti, Marina Urena, Dominique Himbert, Walid Ghodbane, Constance Gardy Verdonk, Coppelia Goublaire, Soleiman Alkhoder, Richard Raffoul, Jose Luis Carrasco, Mikael Laredo, Patrick Nataf, Alec Vahanian
AIMS: To evaluate the feasibility, safety and outcomes of TAVI performed via the suprasternal brachiocephalic approach in selected patients at high or prohibitive surgical risk who are not eligible for transfemoral or subclavian TAVI. METHODS AND RESULTS: From March 2014 to March 2016, 26 high-risk patients without transfemoral or subclavian access options were considered for TAVI via a suprasternal brachiocephalic approach. The feasibility of the suprasternal brachiocephalic approach was determined according to computed tomography findings and after...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840323/quantitative-angiographic-characterization-of-coronary-artery-disease-in-patients-with-human-immunodeficiency-virus-hiv-infection-undergoing-percutaneous-coronary-intervention
#17
Kleanthis Theodoropoulos, Marco G Mennuni, Samantha Sartori, Omar A Meelu, Jennifer Yu, Usman Baber, Giulio G Stefanini, Ioannis Mastoris, Pedro Moreno, George D Dangas, Roxana Mehran, Samin K Sharma, Annapoorna S Kini
AIMS: Patients with human immunodeficiency virus (HIV) infection have an increased risk of acute myocardial infarction (MI) and 6.5 -15% of mortality in this population is attributable to cardiovascular disease. However, the angiographic pattern of coronary artery disease (CAD) in patients with HIV undergoing percutaneous coronary intervention (PCI) remains unknown. We sought to assess and describe the angiographic features and burden of CAD in patients with HIV as compared to those without HIV infection...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27840322/twelve-month-results-of-a-prospective-multicentre-trial-to-assess-the-everolimus-eluting-coronary-stent-system-promus-element-the-platinum-plus-all-comers-randomised-trial
#18
Jean Fajadet, Franz-Josef Neumann, David Hildick-Smith, Sonia Petronio, Azfar Zaman, Mark Spence, Jochen Wöhrle, Simon Elhadad, David Roberts, Thomas Hovasse, Mariano Valdés, Sigmund Silber
AIMS: To compare the safety and efficacy of the platinum-chromium based everolimus- eluting stent (EES) with a cobalt-chromium EES. METHODS AND RESULTS: We performed a prospective, multicentre, single-blind non-inferiority all-comers study randomising patients with stable or unstable coronary artery disease (2:1) to treatment with the platinum-chromium EES (n=1952) or the control cobalt-chromium EES (n=1028) in Europe (PLATINUM PLUS Trial). The primary endpoint was target vessel failure (TVF) at 12 months: a composite of target-vessel related cardiac death, myocardial infarction (MI), and ischaemia-driven target-vessel revascularisation (TVR)...
November 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27821376/a-cardiac-catheterisation-laboratory-core-curriculum-for-the-continuing-professional-development-of-nurses-and-allied-health-professions
#19
Lynne Hinterbuchner, Salomé Coelho, Ricardo Esteves, Sarah Carson, Lene Kløvgaard, Lino Gonçalves, Stephan Windecker, David Zughaft
AIMS: The aim is to provide a standard educational structure for nurses and allied professionals (NAP) specialising in interventional cardiology. The curriculum can also be used as a basis for training on a certificate- based level in interventional cardiology. METHODS AND RESULTS: The curriculum was developed by a panel of experts from various allied health professions. The syllabus focuses on nine core areas of themes essential for NAPs working in interventional cardiology...
November 8, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27821375/impact-of-lesion-calcification-on-angiographic-outcomes-after-absorb-everolimus-eluting-bioresorbable-vascular-scaffold-implantation-an-observation-from-the-absorb-japan-trial
#20
Masanobu Ohya, Kazushige Kadota, Yohei Sotomi, Ken Kozuma, Kengo Tanabe, Masaaki Uematsu, Tomohiro Kawasaki, Yoshihiro Morino, Tetsuya Tobaru, Koichi Nakao, Kouichi Tachibana, Koichi Kishi, Yoshisato Shibata, Shihwa Ying, Hajime Kusano, Gregg W Stone, Jeffery J Popma, Yoshinobu Onuma, Patrick W Serruys, Takeshi Kimura
AIMS: We investigated the impact of lesion calcification on angiographic outcomes after Absorb everolimus-eluting bioresorbable vascular scaffold (BVS) implantation in comparison with those after cobalt chromium everolimus-eluting stent (CoCr-EES) implantation. METHODS AND RESULTS: The present post-hoc analysis of the ABSORB Japan randomized trial compared post-procedure and 13-month angiographic outcomes between patients implanted with BVS and CoCr-EES based on the presence or absence of calcification, excluding extremely heavily calcified lesions or lesions requiring rotational atherectomy...
November 8, 2016: EuroIntervention
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