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Anthony Main, Andrew Starovoytov, Amir Sabbaghan, Eve Aymong, G B John Mancini, Jacqueline Saw
AIMS: Spontaneous coronary artery dissection (SCAD) is an under-recognized and important cause of myocardial infarction in young women. Recurrent SCAD is frequent but poorly understood. We aim to explore the clinical and angiographic characteristics, and outcomes of recurrent SCAD. METHODS AND RESULTS: Patients with SCAD extension or recurrence prospectively followed at Vancouver General Hospital were included in this retrospective study. SCAD diagnosis was confirmed by 2 experienced cardiologists...
September 12, 2017: EuroIntervention
Antoine Filipovic-Pierucci, Isabelle Durand-Zaleski, Thibault Butel, Samantha Greene, Thomas Hovasse, Andres Iñiguez, Marco Stefano Nazzaro, Keith G Oldroyd, Suneel Talwar, Gert Richardt, Ute Windhovel, Philip Urban, Marie-Claude Morice
AIMS: In patients at high risk of bleeding who undergo PCI the biolimus A9 polymer-free drug coated stent (DCS) has superior efficacy and safety compared to a bare metal stent (BMS). We estimated the cost effectiveness of DCS vs. BMS. METHODS AND RESULTS: The Leaders FREE-based economic evaluation estimated service use and quality of life data collected prospectively. The entire trial population was analysed using cost-weights from England, France, Germany, Italy, Scotland and Spain...
September 12, 2017: EuroIntervention
Leonardo Danduch, Xavier Millán, Chi Hion Li, Dabit Arzamendi
No abstract text is available yet for this article.
September 12, 2017: EuroIntervention
Yoshinobu Murasato, Takahiro Mori, Takayuki Okamura, Junya Shite
We encountered two cases that resulted in unusual deflection of the protruded struts after proximal optimization technique (POT) with side branch (SB) dilation in coronary bifurcation stenting, when the guide wires recrossed into proximal cells of the struts overhung in the SB ostium. In one case, POT before SB dilation enabled adequate strut expansion with some deflection toward the distal SB, and subsequent SB dilation completed this deflection. In another case, POT after SB dilation resulted in the deflection toward distal main branch, opposite side of the previous case...
September 12, 2017: EuroIntervention
Marianna Adamo, Claudia Fiorina, Salvatore Curello, Giuliano Chizzola, Elena Pezzotti, Emanuele Gavazzi, Luca Branca, Ermanna Chiari, Filippo Quinzani, Michele Rinaldi, Marco Metra, Federica Ettori
AIMS: The aim of this study was to report clinical outcomes of self-expanding transcatheter aortic valve implantation (TAVI) for failed small Mitroflow (MF) bioprostheses. METHODS AND RESULTS: Between January 2013 and July 2016, 15 symptomatic patients (NYHA Class ≥III) with degenerated small MF (≤23 mm) underwent CoreValve (CV) or Evolut R (EvR) implantation due to high/prohibitive risk for surgical redo. The MF size was 19 or 21 mm (off-label in Europe) in eight patients...
September 10, 2017: EuroIntervention
Lisette Okkels Jensen, Michael Maeng, Bent Raungaard, Knud Nørregaard Hansen, Johnny Kahlert, Svend Eggert Jensen, Henrik Steen Hansen, Jens Flensted Lassen, Hans Erik Bøtker, Evald Høj Christiansen
AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population. METHODS AND RESULTS: The 2-year pre-specified endpoint target lesion failure did not differ significantly between the sirolimus-eluting stent: 6.7% and the biolimus-eluting stent: 7.0% (rate ratio (RR) 0...
September 5, 2017: EuroIntervention
Neil P Fam, Edwin C Ho, Naveed Ahmed, Kim A Connelly
No abstract text is available yet for this article.
September 5, 2017: EuroIntervention
Saumya Shah, Elad Maor, David L Joyce, Charanjit S Rihal
No abstract text is available yet for this article.
September 5, 2017: EuroIntervention
Ernesto Valero, Luciano Consuegra-Sánchez, Gema Miñana, Sergio García-Blas, Juan Carlos Rodríguez, Patricia Moyano, Juan Sanchis, Julio Núñez
AIMS: To describe our initial experience with the novel BioMime™ 60mm-long sirolimus-eluting tapered coronary stent system in patients with long coronary lesions. METHODS AND RESULTS: We included 50 consecutive patients in whom a 60mm-long drug- eluting stent (DES) implantation was attempted due to the presence of coronary lesions longer than 48mm. The 60mm-long DES was successfully implanted in 46 (92%) patients. In 4 patients stent deployment failed due to the impossibility of crossing completely the lesions...
September 5, 2017: EuroIntervention
Deborah N Kalkman, Marlies M Kok, Liefke C van der Heijden, Pier Woudstra, Marcel Am Beijk, Jan Gp Tijssen, Clemens von Birgelen, Robbert J de Winter
AIMS: The COMBO stent combines a sirolimus-elution with an endothelial progenitor cell- capturing layer to promote early endothelialization. There has not been a head-to-head comparison of this novel device with any other currently used drug-eluting stent (DES). We compare clinical outcome at 2-years after COMBO stent placement with the Resolute Integrity or Promus Element stent in an all-comers cohort. METHODS AND RESULTS: Patients from the REMEDEE Registry (COMBO, n=1000) were matched with patients from the DUTCH PEERS trial (Promus Element/Resolute Integrity, n=1811)...
September 5, 2017: EuroIntervention
Stefan Toggweiler, Henrik Nissen, Brynjolfur Mogensen, Florim Cuculi, Christian Fallesen, Karsten Tange Veien, Miriam Brinkert, Richard Kobza, Andreas Rück
AIMS: Investigate if minimizing trauma to the aortic annulus and left ventricular outflow tract reduces the occurrence of new conduction disorders and need for permanent pacemakers. METHODS AND RESULTS: A total of 175 patients (58% women, mean age 83 ± 6 years) underwent transfemoral TAVI with the Boston Scientific ACURATE neo at three centers in Europe. Prosthesis size selection was based on perimeter derived annular diameter. Predilatation was performed in all with a balloon 1...
September 5, 2017: EuroIntervention
Nasser M Malyar, Klaus Kaier, Eva Freisinger, Florian Lüders, Gerrit Kaleschke, Helmut Baumgartner, Lutz Frankenstein, Holger Reinecke, Jochen Reinöhl
AIMS: Peripheral artery disease (PAD) is common in patients with aortic valve stenosis (AS). We assessed the prevalence of critical limb ischemia (CLI) and its impact on in-hospital outcome in patients undergoing transcatheter aortic valve implantation (TAVI) for severe AS. METHODS AND RESULTS: All isolated TAVI in Germany between 2007 and 2013 for AS were analysed regarding stage specific prevalence of PAD, comorbidities, in-hospital complications and mortality using diagnostic and procedural codes...
September 5, 2017: EuroIntervention
Fabrizio D'Ascenzo, Umberto Benedetto, Matteo Bianco, Federico Conrotto, Claudio Moretti, Augusto D'Onofrio, Marco Agrifoglio, Antonio Colombo, Flavio Ribichini, Giuseppe Tarantini, Maurizio D'Amico, Stefano Salizzoni, Fiorenzo Gaita
AIMS: Safety and efficacy of single vs. dual antiplatelet therapy (DAPT) in patients undergoing TAVI remain to be addressed. METHODS AND RESULTS: All consecutive patients enrolled in the ITER registry were included. Patients undergoing TAVI discharged with aspirin alone were compared to those assuming DAPT before and after selection with propensity score with matching. Subgroup analysis was performed for those on OAT. Prosthetic heart valve dysfunction at follow-up was the primary end point whereas all cause death, cardiovascular death, bleedings, vascular complications and cerebrovascular accidents were the secondary ones...
September 5, 2017: EuroIntervention
Yigal Abramowitz, Tarun Chakravarty, Philippe Pibarot, Yoshio Maeno, Hiroyuki Kawamori, David Anderson, Geeteshwar Mangat, Mamoo Nakamura, Wen Cheng, Raj R Makkar
AIMS: Only few studies examined the respective impact of low flow (LF), low gradient (LG) and low ejection fraction (LEF) on outcomes following transcatheter aortic valve replacement (TAVR). The purpose of this study was to assess the impact of pre-procedural stroke volume index, aortic valve gradient, left ventricular ejection fraction (LVEF) and different flow/gradient/LVEF patterns on the clinical outcomes of patients with severe aortic stenosis (AS) that undergo TAVR. METHODS AND RESULTS: We analyzed the clinical, echocardiographic, and outcome data collected in 770 patients with AS that underwent TAVR...
September 5, 2017: EuroIntervention
Amnon Eitan, Claudia Tiburtius, Julian Witt, Joachim Schofer
No abstract text is available yet for this article.
August 29, 2017: EuroIntervention
Roberto Scarsini, Gabriele Pesarini, Carlo Zivelonghi, Anna Piccoli, Valeria Ferrero, Mattia Lunardi, Leonardo Gottin, Claudia Zanetti, Giuseppe Faggian, Flavio Ribichini
AIMS: We sought to assess eventual changes in iFR measurements in patients with aortic stenosis (AS) before and after TAVI in coronary lesions with different degree of angiographic severity. METHODS AND RESULTS: The functional relevance of 145 coronary lesions was assessed by on-line iFR and FFR measurement in 66 patients with severe AS before and after TAVI, during the same procedure. The iFR-FFR classification agreement was calculated for pre- and post-TAVI measurements...
August 29, 2017: EuroIntervention
Ulrich Schäfer, Johannes Schirmer, Niklas Schofer, Eva Harmel, Florian Deuschl, Lenard Conradi
The first case of a novel JenaValve design using the transfemoral approach in a 78 year old female patient with pure aortic regurgitation is described. The implantation was successfully performed with excellent haemodynamics and good clinical outcome at 6 months follow up. The technology is especially appealing in non-calcified anatomies due to the clipping mechanism that has been previously utilized in the transapical design.
August 29, 2017: EuroIntervention
Lars Jakobsen, Evald H Christiansen, Michael Maeng, Knud N Hansen, Steen D Kristensen, Hans E Bøtker, Christian J Terkelsen, Svend E Jensen, Bent Raungaard, Morten Madsen, Jens F Lassen, Lisette O Jensen
AIMS: To report long-term safety and efficacy of the biodegradable polymer-coated biolimus-eluting Nobori stent compared to the durable polymer-coated sirolimus-eluting Cypher stent. METHODS AND RESULTS: SORT OUT V randomized 2,468 patients 1:1 to the Nobori (n=1,229) versus the Cypher stent (n=1,239). Clinically driven event detection based on Danish registries was used. The primary endpoint was a composite of safety (cardiac death, myocardial infarction, definite stent thrombosis) and efficacy (target vessel revascularization)...
August 29, 2017: EuroIntervention
Gregory J Wilson, Jennifer McGregor, Gerard Conditt, Masahiko Shibuya, Natalia Sushkova, Michael J Eppihimer, Steven P Hawley, Serge D Rousselle, Barbara A Huibregtse, Keith D Dawkins, Juan F Granada
AIMS: Drug-Eluting Stents (DES) have evolved to bioresorbable polymers as a method of drug delivery. The impact of bioresorbable polymer on long-term neointimal formation, inflammation, and healing has not been fully characterized. METHODS AND RESULTS: A comparative DES study was performed in the Familial Hypercholesterolemic Swine model of coronary stenosis. Permanent-polymer DES (zotarolimus- eluting [ZES] or everolimus- eluting [EES]) were compared to bioresorbable polymer everolimus-eluting stents (BP-EES) and BMS...
August 29, 2017: EuroIntervention
Kazunori Horie, Norio Tada, Tsuyoshi Isawa, Takashi Matsumoto, Masataka Taguri, Shigeaki Kato, Taku Honda, Tatsushi Ootomo, Naoto Inoue
AIMS: To compare incidences of radial artery occlusion (RAO) and spasm (RAS) associated with transradial coronary intervention (TRI) using 6.5-Fr Sheathless hydrophilic-coated guide catheter (SH-GC) vs. 6.0-Fr Glidesheath Slender (GSS). METHODS AND RESULTS: We conducted an open-label, single-centre, randomized study to compare radial complications in 600 consecutive patients undergoing elective TRI using 6.5-Fr SH-GC (n=300) or 6.0-Fr GSS (n=300) between 2015 and 2016...
August 29, 2017: EuroIntervention
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