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Clinical Cases in Mineral and Bone Metabolism

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https://www.readbyqxmd.com/read/29354171/the-challenge-of-nonunion-after-osteosynthesis-of-the-clavicle-is-it-a-biomechanical-or-infection-problem
#1
Giuseppe Rollo, Paolo Pichierri, Antonio Marsilio, Marco Filipponi, Michele Bisaccia, Luigi Meccariello
Introduction: The nonunion rate has been reported between 0.1% and 15%. There are also several predisposing factors for the onset of complications: general factors connected with the patient and specific factors related to the fracture site. The purpose of our study is to review the etiology of nonunion of the clavicle in its atrophic form and investigate the outcomes of the revision treatment in a single step. Materials and methods: Retrospective study on 71 patients suffering from nonunions due to the following treatments: conservative in 13 patients; plate fixation in 12; closed reduction and fixation with K-wire in 24; open reduction and fixation with K-wire...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354170/subtrochanteric-femoral-stress-fracture-with-features-of-atypical-femoral-fracture-in-patient-with-paget-s-disease-a-case-report
#2
Young-Kyun Lee, Hong Seok Kim, Hwan Seong Cho, Kyung-Hoi Koo
Atypical femoral fracture (AFF) has been widely issued since the American Society for Bone and Mineral Research (ASBMR) taskforce stated a possible association with long-term use of bisphosphonate in 2010. ASBMR taskforce recommended to include Paget's disease as one of variables to investigate the AFF in 2010. On the other hand, the ASBMR taskforce in 2014 excluded Paget's disease in the definition of AFF. Still, any rationale has been barely documented about this change. We described the rationale by reporting an 85-year-old man who had a subtrochanteric fracture with features of atypical femoral fracture which turned out to be Paget's disease of bone in the pathology...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354169/femur-shaft-fracture-following-osteoid-osteoma-radiofrequency-ablation
#3
Elias Mazzawi, Daniela Militianu, Mark Eidelman, Yaniv Keren
Introduction: Radiofrequency ablation is an effective modality in treating osteoid osteoma while avoiding the complications of an open procedure. Its complications are usually self-limited consisting mostly of local skin burns. This report presents a major complication, a femur shaft fracture following an osteoid osteoma radiofrequency ablation. The fracture occurred approximately one year after the ablation at the site of the osteoid osteoma. Discussion: Few case reports have been published regarding subtrochanteric femur fracture after ablation of an osteoid osteoma...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354168/glomus-tumor-as-a-cause-of-oncogenic-osteomalacia
#4
Mehdi Dehghani, Mohammad Hossien Dabbaghmanesh, Abolfazele Khalafi-Nezhad, Nader Riazmontazer, Amireza Dehghanian, Reza Vojdani, Mohammadreza Sasani
Many tumors that occasionally are benign in origin causes hypophosphatemic osteomalacia. Here we present a case of glomus tumor in a 59-year-old man with oncogenic osteomalacia. Diagnosis was made after observation of abnormal increase activity in octreotide scan. The magnetic resonance imaging showed a round lesion in left ankle joint. Surgical excision of tumor was curative and all symptoms and intractable hypophosphatemia improved after few weeks.
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354167/neonatal-severe-hyperparathyroidism-secondary-to-a-novel-homozygous-casr-gene-mutation
#5
Noman Ahmad, Mona Bahasan, Balgees Abdulhadi Abdullah Al-Ghamdi, Halah Faleh Al-Enizi, Ali Saeed Al-Zahrani
Neonatal severe hyperparathyroidism (NSHPT) is a rare autosomal recessive disease. Children present within the first 6 months of life and more commonly in the first few weeks. Common presentation is poor feeding, polyuria, dehydration, lethargy, failure to thrive, hypotonia, gastrointestinal dysmotility, osteopenia and symptoms of respiratory distress due to a poorly developed chest cage. We present a case of a 2-month old girl with severe hypercalcemia and hyperparathyroidism. She was found to have a novel homozygous mutation in the acceptor splicing site of intron 4 (c...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354166/adult-onset-hypophosphatasia-diagnosed-following-bilateral-atypical-femoral-fractures-in-a-55-year-old-woman
#6
John E Lawrence, Danish Saeed, Jonathan Bartlett, Andrew D Carrothers
We report the case of a 55-year-old woman who presented to the emergency department having woken from sleep with right sided thigh swelling. Pelvic radiographs revealed bilateral atypical subtrochanteric femoral fractures (ASFFs). In the two years leading up to this admission, the patient had experienced gradually increasing pain and weakness in her legs which had resulted in a decrease in her mobility from fully mobile to bed-bound. During this time a neurologist had organised a magnetic-resonance imaging (MRI) scan of the brain and spine which was normal...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354165/calcitriol-mediated-hypercalcemia-secondary-to-granulomatous-disease-caused-by-soft-tissue-filler-injection-a-case-report
#7
Jairo Arturo Noreña, César Daniel Niño, Sabrina Gallego, Carlos Alfonso Builes-Barrera, Diva Cristina Castro, Alejandro Román-González, Camilo Jimenez
Soft-tissue filler (STF) injections have been used worldwide for cosmetic reasons. In most cases, they are not approved by the United States Food and Drug Administration (FDA). Regulatory boards in Latin American countries do not allow the medical use of STF injections; however, these injections are still widely used. A case of calcitriol-mediated hypercalcemia with ectopic calcifications, chronic kidney disease, nephrolithiasis and calcinosis is presented. The reported case highlights the consequences of STF use, including calcitriol-mediated hypercalcemia secondary to granulomatous reactions years after an esthetic procedure...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354164/actual-reason-for-bone-fractures-in-the-case-of-a-patient-followed-up-with-the-osteogenesis-imperfecta-gaucher-s-disease
#8
Ufuk Demirci, Ahmet Çizmecioglu, Ismet Aydogdu
Gaucher's disease (GD) is a rare disease characterized by a β-glucocerebroside accumulation in the reticulo-endothelial system. Patients may refer to the clinic with complaints of bone pain, hepatosplenomegaly, anemia, thrombocytopenia, growth retardation, interstitial pulmonary disease, pulmonary hypertension, and skeletal disorders. Skeletal system involvement is observed commonly in Gaucher patients and a significant cause of morbidity. Our patient was followed for several years as a glass child - osteogenesis imperfecta and he had joint deformities due to skeletal fractures...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354163/secondary-aneurysmal-bone-cyst-in-mccune-albright-syndrome
#9
Symeon Tournis, Alexia Balanika, Panayiotis D Megaloikonomos, Andreas F Mavrogenis
Polyostotic fibrous dysplasia in combination with caféau-lait macules and hyperfunctioning endocrinopathies consists of a rare clinical condition termed as McCune-Albright syndrome. Aneurysmal bone cysts are tumor-like cystic lesions, composed of blood-filled compartments. They may occur as primary lesions or secondary to other pathologies; most commonly giant cell tumors of bone. However, secondary aneurysmal bone cysts in McCune-Albright syndrome are exceptional. We present a 28-year-old female with McCune-Albright syndrome...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354162/pitfalls-in-interpreting-interventional-studies-for-osteoporosis
#10
REVIEW
Mohammad Shafi Kuchay, Beena Bansal, Ambrish Mithal
After adulthood, changes in the skeleton are slow and takes years for accruing or losing any appreciable amount of bone mass. Proper interpretation of studies that evaluate the effect of nutrients (like calcium, vitamin D) and anti-resorptive agents (like bisphosphonates) on bone mass is important so that the true effect of the agent is measured correctly. In this report, we are highlighting two issues of utmost importance for correctly interpreting interventional studies for osteoporosis. One issue is the bone remodelling transient (BRT)...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354161/atypical-femur-fractures-a-distinctive-tract-of-adult-hypophosphatasia
#11
REVIEW
Francesca Marini, Maria Luisa Brandi
Hypophosphatasia (HPP) is a congenital, rare and heterogeneous bone disorder, characterized by a deficit of calcified tissue mineralization, leading to skeletal deformities and osteomalacia in adults, rickets in infants and children, and fragility fractures and premature loss of dentition in children and adults. The disease is caused by a reduced or absent expression and activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, derived from inactivating mutations of the alkaline phosphatase ( ALPL ) gene...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354160/surgical-treatment-of-neglected-hip-fracture-in-children-with-cerebral-palsy-case-report-and-review-of-the-literature
#12
REVIEW
Giuseppe Toro, Antimo Moretti, Gabriella Toro, Assunta Tirelli, Giampiero Calabrò, Antonio Toro, Giovanni Iolascon
Case: A clinical case of a 15-year-old cerebral palsy child with a Sandhu type 2 neglected femoral neck fracture is presented. The patient was treated using cannulated screws and cancellous bone graft augmented with mesenchymal stem cells. At 6 months after the surgery complete fracture healing was observed. Conclusion: To early diagnose this fractures, it is mandatory to perform a comprehensive clinical and radiological evaluation including also a second level imaging...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354159/hypothyrodism-as-a-risk-factor-of-periodontitis-and-its-relation-with-vitamin-d-deficiency-mini-review-of-literature-and-a-case-report
#13
REVIEW
Nermin M Yussif, Fatema Mohammed El-Mahdi, Rasha Wagih
Objective: The purpose of this report is to investigate the role and efficiency of the intra-ligamentary injection of vitamin D and calcium in the treatment of chronic periodontitis associated with hypothyroidism. Design: A 43-year-old female with suspected hypothyroidism who revealed severe chronic periodontitis with grade III mobility. Pre-operative periodontal and systemic control preceded the used intervention. After 3 months, intra-ligamentary injectable vitamin D with calcium was introduced...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354158/effect-of-combined-treatment-with-focused-mechano-acoustic-vibration-and-pharmacological-therapy-on-bone-mineral-density-and-muscle-strength-in-post-menopausal-women
#14
Raoul Saggini, Emilio Ancona, Simona Maria Carmignano, Marco Supplizi, Giovanni Barassi, Rosa Grazia Bellomo
Introduction: Osteoporosis is a systemic disease of the skeleton characterized by a reduction in bone mass and alterations in microarchitecture accompanied by increase in fracture risk, with a relevant decline in quality of life and important social, economic, and health implications, representing one of the most common causes of disability and a major financial item of health cost in many Countries. The best therapy for osteoporosis is prevention, consisting in measures to avoid or slow the onset of the disease...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354157/grafting-and-fixation-of-proximal-humeral-aseptic-non-union-a-prospective-case-series
#15
Giuseppe Rollo, Roberto Rotini, Paolo Pichierri, Marco Giaracuni, Alessandro Stasi, Luca Macchiarola, Michele Bisaccia, Luigi Meccariello
Background: Fractures of the proximal part of the humerus represent almost 4-5% of all fractures. The rate of non union is estimated to be 1.1 to 10%. Non union, displacement, and fixation failure can be hazardous complications for these injuries. The purpose of our study was to evaluate the outcomes of plate and bone strut allograft with bone chips grafting augmentation in the management of proximal humeral aseptic non union. Methods: We treated 16 aseptic non union proximal humeral fractures by the medial humeral shaft bone strut allograft and lateral plate and screws with bone chips grafting...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354156/lower-limbs-heterometry-correction-in-patients-with-osteoporosis-and-increased-risk-of-falls
#16
Elisa Pratelli, Angelo Alito, Claudio Zanella, Laura Busi, Giuseppe Mangone, Matteo Scarselli, Pietro Pasquetti
Osteoporotic fractures are associated with a significant increase in morbidity, mortality and medical costs. There is also a strong link between fractures and increased mortality. Among effective measures for the prevention of falls, instability treatment surely plays a crucial role. Several factors contribute to instability, many of which are ageing-related: visual spatial deficit, strength reduction, weight imbalance with COP lateralization sometimes favoured by LLD (leg length discrepancy). It seems useful to detect an heterometry which could be corrected, if present...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29354155/the-effect-of-strontium-chloride-on-human-periodontal-ligament-stem-cells
#17
Cecilia Romagnoli, Roberto Zonefrati, Gianna Galli, Alessandra Aldinucci, Niccolò Nuti, Francesco Saverio Martelli, Paolo Tonelli, Annalisa Tanini, Maria Luisa Brandi
The complete repair of periodontal structures remains an exciting challenge that prompts researchers to develop new treatments to restore the periodontium. Recent research has suggested strontium ion to be an attractive candidate to improve osteogenic activity. In this study, we have isolated a clonal finite cell line derived from human periodontal ligament (PDL) in order to assess whether and in which way different doses of SrCl2 (from 0.5 to 500 μg/ml) can influence both the proliferation and the mineralization process, for future application in oral diseases...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29263750/periostin-and-sclerostin-levels-in-juvenile-paget-s-disease
#18
Stergios A Polyzos, Polyzois Makras, Athanasios D Anastasilakis, Gesthimani Mintziori, Marina Kita, Athanasios Papatheodorou, Panagiotis Kokkoris, Evangelos Terpos
Juvenile Paget's disease (JPD) is a rare, autosomal recessive disorder featuring markedly increased serum alkaline phosphatase activity, indicative of greatly accelerated bone turnover throughout the skeleton. The main aim of this study was to evaluate circulating periostin and sclerostin levels in two adult patients with mild JPD (due to "Balkan" mutation). We measured periostin and sclerostin levels in a previously described woman and a newly diagnosed man with JPD, and 10 apparently healthy individuals, matched (1:5) to JPD patients for gender, age and body mass index...
May 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29263749/giant-schwannoma-of-the-foot-a-case-report-and-literature-review
#19
Francesco Muratori, Marco De Gori, Francesco Rosario Campo, Leonardo Bettini, Antonio D'Arienzo, Guido Scoccianti, Rodolfo Capanna
A schwannoma is a rare, benign tumor originating from Schwann cells of peripheral nerve sheath. It commonly occurs in subjects between 20 and 50 years of age, and its malignant transformation is exceptional. While schwannomas usually affect the head and neck region, localization in the lower extremity is exceptionally rare, and even fewer cases have described schwannomas occurring in the foot. We report a case of a giant schwannoma of the foot diagnosed in a 65-year-old woman. A giant schwannoma of the foot is an extremely rare soft tissue tumor...
May 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29263748/hydatid-cyst-in-the-vastus-lateralis-muscle-a-case-report
#20
Francesco Muratori, Marco De Gori, Antonio D'Arienzo, Leonardo Bettini, Giuliana Roselli, Domenico Andrea Campanacci, Rodolfo Capanna
Hydatidosis is a zoonotic disease; human infection occurs through the consumption of food and water contaminated with the eggs of parasites of the Echinococcus type. While the liver is the most common site of infection, involvement of the musculoskeletal system is extremely rare. In the context of musculoskeletal involvement, the spine is the most commonly infected site, while the muscles are rarely infected and account for approximately <1% of cases. It has been suggested that muscles provide an unsuitable environment for the parasite, because of the presence of lactic acid...
May 2017: Clinical Cases in Mineral and Bone Metabolism
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