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Journal of Dietary Supplements

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https://www.readbyqxmd.com/read/29708806/ashitaba-angelica-keiskei-exudate-prevents-increases-in-plasminogen-activator-inhibitor-1-induced-by-obesity-in-tsumura-suzuki-obese-diabetic-mice
#1
Mitsuhiro Ohta, Aya Fujinami, Katsutaka Oishi, Norihiro Kobayashi, Katsunori Ohnishi, Naoki Ohkura
Angelica keiskei koidzumi (ashitaba) is consumed as a traditional folk medicine and health food in Japan. Ashitaba extract contains abundant flavonoids containing chalcones. Plasminogen activator inhibitor-1 (PAI-1) is the primary physiological inhibitor of tissue plasminogen activator. Excessive amounts of PAI-1 in plasma disrupt the fibrinolytic balance and promote a prothrombotic state with which thrombosis and cardiovascular diseases are associated. In the present study, we investigated the effects of ashitaba yellow exudate (AE) on enhanced PAI-1 levels in Tsumura Suzuki obese diabetic (TSOD) mice...
April 30, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29701491/effects-of-shiitake-intake-on-serum-lipids-in-rats-fed-different-high-oil-or-high-fat-diets
#2
Norihiko Asada, Rumi Kairiku, Mika Tobo, Akifumi Ono
Shiitake (Lentinula edodes) extract, eritadenine, has been shown to reduce cholesterol levels, and its hypocholesterolemic actions are involved in the metabolism of methionine. However, the mechanisms by which eritadenine affects cholesterol metabolism in animals fed a high-fat diet containing different sources of lipids have not yet been elucidated in detail. This study was conducted to investigate the effects of shiitake supplementation on serum lipid concentrations in rats fed a diet including a high amount of a plant oil (HO [high oil] and HOS [high oil with shiitake] groups), animal fat (HF [high fat] and HFS [high fat with shiitake] groups), or MCT- (medium-chain triglyceride-) rich plant oil (HM [high MCT] and HMS [high MCT with shiitake] groups)...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#3
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29694254/acute-and-subchronic-toxicological-evaluations-of-allium-rotundum-l-a-dietary-plant-from-iran
#4
Leila Hosseinzadeh, Sajad Farhangian, Marziyeh Hajialyani, Arash Bahari, Mohammad Hosein Farzaei
Allium rotundum L. is a dietary plant with diverse nutritional and herbal applications. According to its widespread application in Iranians' diets, understanding the possible adverse effects and toxic activities could be of major importance. The aim of this study was to establish the acute and subchronic toxicity profile of the hydroalcoholic extract of Allium rotundum on male and female Wistar rats. The acute study indicated no adverse effect or toxic activity after administration of the extract, suggesting that the LD50 value is up to 5,000 mg/kg body weight for the extract...
April 25, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29672196/the-effects-of-synbiotic-supplementation-on-body-mass-index-metabolic-and-inflammatory-biomarkers-and-appetite-in-patients-with-metabolic-syndrome-a-triple-blind-randomized-controlled-trial
#5
Samira Rabiei, Mehdi Hedayati, Bahram Rashidkhani, Navid Saadat, Rahebeh Shakerhossini
It has been shown recently that metabolic syndrome is associated with gut dysbiosis. The gut microbiota may be the main target for prevention or treatment of metabolic syndrome. We investigated the effects of synbiotic supplementation on metabolic syndrome. In this triple-blinded clinical trial, 46 Iranian patients with metabolic syndrome, from both sexes, aged 25-70 years, who fulfilled inclusion criteria were randomly categorized to receive either the synbiotic or a placebo capsule, twice a day for three months, plus a weight-loss diet using stratified random sampling based on body mass index (BMI)...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29672189/abrogation-of-hepatic-damage-induced-by-anticancer-drug-methotrexate-by-zobo-hibiscus-sabdariffa-extract-supplementation-via-targeting-oxidative-hepatotoxicity-in-rats
#6
Ademola C Famurewa, Abiola M Folawiyo, Michael A Epete, Emeka C Igwe, Paul I Okike, Ekenechukwu K Maduagwuna
Clinical use of methotrexate (MTX) in cancer chemotherapy is limited due to its side effects, notably associated with increased oxidative stress and hepatotoxicity. Zobo is an aqueous extract of Hibiscus sabdariffa known to contain natural antioxidants. The present study investigated the hepatoprotective effect of zobo drink (ZD) on MTX-induced oxidative stress and hepatotoxicity in rats. Rats randomized to control group received distilled water orally; MTX group received intraperitoneal (ip) injection of MTX (20 mg/kg) on day 11; ZD + MTX group was administered ZD (10 ml/kg) for 14 days and was injected with MTX on day 11...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29672184/oral-supplementation-with-beta-hydroxy-beta-methylbutyrate-arginine-and-glutamine-improves-lean-body-mass-in-healthy-older-adults
#7
Amy C Ellis, Gary R Hunter, Amy M Goss, Barbara A Gower
Oral intake of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine may ameliorate muscle loss by stimulating protein synthesis and decreasing protein degradation while simultaneously decreasing inflammation. Previous studies provide evidence for improvement in body composition with dietary supplementation of these ingredients among patients with muscle-wasting diseases. The objectives of this study were to examine the effects of this amino acid mixture on lean body mass, muscle volume, and physical function among healthy older adults...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29672181/pilates-physical-activity-and-diet-survey-an-italian-self-administered-questionnaire-evaluating-diet-habits-of-gym-goers-validation-process
#8
Vincenza Gianfredi, Daniele Nucci, Francesco Ceccarelli, Milena Villarini, Massimo Moretti
PILATES study aims are to assess the main characteristics related to food habits, diet behaviors, and nutrition knowledge and how and where gym-goers get information on dietary supplementation. We present evidence for the reliability, feasibility, and construct validity of the PILATES questionnaire. Cohen's kappa statistic (k) for dichotomous variables was used to assess the agreement between the two administrations (interrater agreement). The nutrient composition and energy of food were derived from the Food Composition Database for Epidemiological Studies in Italy (Banca Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia - BDA)...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29667462/glucosamine-for-the-treatment-of-osteoarthritis-the-time-has-come-for-higher-dose-trials
#9
Mark F McCarty, James H O'Keefe, James J DiNicolantonio
Although clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysaccharide synthesis and the extent of protein O-GlcNAcylation...
April 18, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29630419/crab-shell-extract-improves-sperm-parameters-and-antioxidant-status-in-testes-of-diabetic-rats
#10
Elham Ghanbari, Mohammad Rasool Khazaei, Parinaz Ahangar, Mozafar Khazaei
Crab shell (CS), which contains antioxidant compounds, has been used as a promising nutritional and medical compound in traditional medicine. Oxidative stress plays a critical role in the development of diabetes. This study aims to investigate the effects of CS extract (CSE) on sperm parameters, antioxidant status, and histopathology changes of testes in diabetic rats. In this experimental study, 40 Wistar male rats were investigated in five groups (n = 8/group): diabetic rats treated with different CS concentrations (i...
April 9, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29624459/-introducing-modified-dakkak-and-bennett-grading-system-for-indian-food-in-oral-submucous-fibrosis-a-dharwad-study
#11
Chaithra Kalkur, Atul P Sattur, Kruthika S Guttal, Anusha R Lakshman
Oral submucous fibrosis (OSMF) is one of the "diseases of civilization" because of the large differences in prevalence among races, geographic areas, and individuals at different socioeconomic levels. It is a premalignant condition strongly associated with the habit of chewing areca nuts. This study is to compare the scoring system in relation to the burning sensation of mouth and dysphagia using the visual analog scale (VAS) and Dakkak and Bennett grading system for Indian food, respectively, in OSMF patients...
April 6, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29624455/assessment-of-antihyperlipidemic-and-antitumor-effect-of-isolated-active-phytoconstituents-from-apium-graveolens-l-through-bioassay-guided-procedures
#12
Deepa Iyer, U K Patil
The seeds of A. graveolens yielded coumarin derivatives such as seselin, methoxsalen, and 3H-isobenzofuran-1-one through chromatographic separation techniques. The structure of the components has been established on the basis of spectral data analysis. The present study was undertaken to explore the antihyperlipidemic and antitumor effects of ethanolic extract and phytoconstituents of A. graveolens in rodents. Albino rats were administered intraperitoneal (i.p.) injection of Triton WR 1339 for the induction of hyperlipidemia at a dose of 400 mg/kg body weight...
April 6, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29621413/alpha-tocopherol-supplementation-restricts-aluminium-and-ethanol-induced-oxidative-damage-in-rat-brain-but-fails-to-protect-against-neurobehavioral-damage
#13
Prasunpriya Nayak, Shiv Bhushan Sharma, N V S Chowdary
The concurrent presence of oxidative stress (OS) and aluminium exposure is an inducer of neurodegenerative changes. Aluminium can augment OS in a pro-oxidant dominant condition. Antioxidative property of α-tocopherol may be useful in restricting these degenerative changes in the brain. OS parameters are tested in frontal cortex (FC), hippocampus (HC), and cerebellum (CL) of α-tocopherol-supplemented (5 IU/day) male Wistar rats exposed to aluminium (10 mg Al/Kg/day; "Al"), ethanol (0.6 g ethanol/Kg/day; "Et"), and both ("Al-Et") and vehicle-treated control ("C") for 4 weeks...
April 5, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29621403/amelioration-of-diabetes-induced-diabetic-nephropathy-by-aloe-vera-implication-of-oxidative-stress-and-hyperlipidemia
#14
Mandeep Kumar Arora, Yogesh Sarup, Ritu Tomar, Mary Singh, Puspendra Kumar
This study investigated the effect of Aloe vera in diabetes-induced nephropathy in rats. As diabetes-associated hyperlipidemia and oxidative stress have been implicated in the pathogenesis of diabetic nephropathy, we evaluated the protective effect of whole leaf extract of Aloe vera on the basis of its hypolipidemic and antioxidative property. Aloe vera (300 mg/kg orally) has been noted to possess renoprotective effect in experimental diabetic nephropathy. However, its mechanism is not fully understood. Rats were administered streptozotocin (STZ) (55 mg/kg intraperitoneally once) to induce experimental diabetes mellitus...
April 5, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29580105/herbal-remedies-a-boon-for-diabetic-neuropathy
#15
Reshu Tiwari, Mohd Haris Siddiqui, Tarique Mahmood, Paramdeep Bagga, Farogh Ahsan, Arshiya Shamim
Diabetic neuropathy is a chronic complication of diabetes mellitus affecting about 50% of patients. Its symptoms include decreased motility and severe pain in peripheral parts. The pathogenesis involved is an abnormality in blood vessels that supply the peripheral nerves, metabolic disorders such as myo-inositol depletion, and increased nonenzymatic glycation. Moreover, oxidative stress in neurons results in activation of multiple biochemical pathways, which results in the generation of free radicals. Apart from available marketed formulations, extensive research is being carried out on herbal-based natural products to control hyperglycemia and its associated complications...
March 26, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29561242/fertaric-acid-protects-from-octylphenol-related-hepatotoxicity-in-rats-biochemical-molecular-and-histopathological-studies
#16
Khaled M M Koriem, Mahmoud S S Arbid
The endocrine-disrupting chemical 4-tert-octylphenol (OP) can mimic estrogen and testosterone hormones and threaten health; fertaric acid (FA) is a hydroxycinnamic acid found in grapefruit. This study aimed to investigate whether FA has a protective effect on 4-tert-octylphenol-related hepatotoxicity. Thirty male albino rats were divided into 5 equal groups of 6 rats each as follows: control group-administrated orally with 1 ml saline 3 days/week for 4 weeks; corn oil group-administrated orally with 1 ml corn oil 3 days/week for 4 weeks; FA-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks; OP-treated group-administrated orally with OP (40 mg /kg body weight) dissolved in corn oil 3 days/week for 4 weeks; FA + OP-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks then administrated orally with OP (40 mg/kg body weight) dissolved in corn oil 3 days/week for another 4 weeks...
March 21, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29561199/dietary-supplement-use-among-students-of-pharmacy-colleges-in-the-city-of-karachi-pakistan-prevalence-opinions-and-attitudes
#17
Atta Abbas Naqvi, Rizwan Ahmad, Fatima Zehra, Raafia Yousuf, Bharti Kachela, Muhammad Nehal Nadir
This study was conducted among pharmacy students in Karachi, Pakistan, to document prevalence, opinions and their attitudes toward dietary supplement (DS) use. A cross-sectional study was conducted for a period of four months. The study used a specially formulated dietary supplement questionnaire (DSQ). The prevalence of DS use was reported at 48.2%: 51% in males and 47.3% in females. Physician recommendation was cited by majority of students as reason for DS use (n = 153, 25%). Most of the students used multivitamins (n = 315, 51...
March 21, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29561197/impact-of-dietary-calcium-supplement-on-circulating-lipoprotein-concentrations-and-atherogenic-indices-in-overweight-and-obese-individuals-a-systematic-review
#18
Javad Heshmati, Mahdi Sepidarkish, Nazli Namazi, Fatemeh Shokri, Mahsa Yavari, Siavash Fazelian, Masoud Khorshidi, Farzad Shidfar
Dyslipidemia is the main risk factor for developing cardiovascular disease. There are discrepancies in the effects of calcium supplementation on modulation of lipid status. Therefore, we aimed to summarize the effects of dietary calcium supplement on circulating lipoprotein concentrations and atherogenic indices in overweight and obese individuals. We conducted a systematic literature search from 2000 until July 2016. PubMed, Scopus, Cochran Library, and ISI Web of Science databases were searched for clinical trials written in English...
March 21, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29537905/characterization-of-bacteria-in-nigerian-yogurt-as-promising-alternative-to-antibiotics-in-gastrointestinal-infections
#19
Anthony Opeyemi Ayeni, Werner Ruppitsch, Funmilola Abidemi Ayeni
Gastrointestinal infections are endemic in Nigeria and several factors contribute to their continual survival, including bacterial resistance to commonly used antibiotics. Nigerian yogurts do not include probiotics, and limited information is available about the antimicrobial properties of the fermenters in the yogurt against gastrointestinal pathogens. Therefore, the antimicrobial potentials of bacteria in Nigeria-produced yogurts against intestinal pathogens were investigated in this study. Viable counts of lactic acid bacteria (LAB) in 15 brands of yogurt were enumerated and the bacteria identified by partial sequencing of 16S rRNA gene...
March 14, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29533686/effects-of-a-multi-ingredient-energy-supplement-on-cognitive-performance-and-cerebral-cortical-activation
#20
Marcos Daou, Julia Montagner Sassi, Matthew W Miller, Adam M Gonzalez
This study assessed whether a multi-ingredient energy supplement (MIES) could enhance cerebral-cortical activation and cognitive performance during an attention-switching task. Cerebral-cortical activation was recorded in 24 young adults (12 males, 12 females; 22.8 ± 3.8 yrs) via electroencephalography (EEG) both at rest and during the attention-switching task before (pretest) and 30 min after (posttest) consumption of a single serving of a MIES (MIES-1), two servings of a MIES (MIES-2), or a placebo (PL) in a double-blinded, randomized crossover experimental design...
March 13, 2018: Journal of Dietary Supplements
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