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Journal of Dietary Supplements

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https://www.readbyqxmd.com/read/28166438/supplementation-of-spirulina-arthrospira-platensis-improves-lifespan-and-locomotor-activity-in-paraquat-sensitive-dj-1%C3%AE-%C3%AE-93-flies-a-parkinson-s-disease-model-in-drosophila-melanogaster
#1
Ajay Kumar, Pearl K Christian, Komal Panchal, B R Guruprasad, Anand K Tiwari
Spirulina (Arthrospira platensis) is a cyanobacterium (blue-green alga) consumed by humans and other animals because of its nutritional values and pharmacological properties. Apart from high protein contents, it also contains high levels of antioxidant and anti-inflammatory compounds, such as carotenoids, β-carotene, phycocyanin, and phycocyanobilin, indicating its possible pharmaco-therapeutic utility. In the present study using DJ-1β(Δ93) flies, a Parkinson's disease model in Drosophila, we have demonstrated the therapeutic effect of spirulina and its active component C-phycocyanin (C-PC) in the improvement of lifespan and locomotor behavior...
February 6, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28165832/comparative-effects-of-alkaloid-extracts-from-aframomum-melegueta-alligator-pepper-and-aframomum-danielli-bastered-melegueta-on-enzymes-relevant-to-erectile-dysfunction
#2
Stephen A Adefegha, Ganiyu Oboh, Bathlomew M Okeke, Sunday I Oyeleye
Aframomum melegueta (alligator pepper (AP)) and Aframomum danielli (bastered melegueta (BM)) seeds have been known to improve sexual function in folkloric medicine. This study investigates the effects of AP and BM seeds' alkaloid extracts on the activities of enzymes (acetylcholinesterase (AChE), angiotensin-1-converting enzyme (ACE), phosphodiesterase-5 (PDE-5), and arginase) relevant to erectile dysfunction (ED). Alkaloids from the seeds were prepared by the solvent extraction method and their interactions with AChE, ACE, PDE-5, and arginase were assessed...
February 6, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28156165/preclinical-safety-assessment-of-furostanol-glycoside-based-standardized-fenugreek-seed-extract-in-laboratory-rats
#3
Pallavi Deshpande, Vishwaraman Mohan, Dilip Ingavale, Jyoti Mane, Mukul Pore, Prasad Thakurdesai PhD
The present work is aimed at studying acute oral toxicity (AOT), subchronic oral toxicity, mutagenicity, and genotoxicity of furostanol glycosides-based standardized fenugreek seed extract (Fenu-FG) using the Organization for Economic Co-operation and Development (OECD) guidelines. The AOT and subchronic (90-day repeated dose) toxicity studies were performed on Wistar rats as per OECD 423 and OECD 408 guidelines, respectively. The mutagenicity (reverse mutation assay, Ames test) and genotoxicity (mammalian chromosome aberration test) were assessed in vitro using OECD 471 and OECD 473 guidelines, respectively...
February 3, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28125355/exploring-vitamin-b12-deficiency-in-sleeve-gastrectomy-from-a-histological-study-of-a-cadaveric-stomach-and-ileum
#4
Dwaipayan Muhuri, Gyorgy M Nagy, Velma Rawlins, Lisa Sandy, Peter Bellot
INTRODUCTION: Vitamin B12 deficiency is more commonly found among patients who have undergone Roux-en-Y gastric bypass (RYGB) as compared to those with post-sleeve gastrectomies (SG). The major difference between SG and RYGB is that the latter greatly bypasses the stomach whereas the former simply reduces the gastric volume. PURPOSE: The aim of this article was to study the stomach and the distal ileum histologically in a cadaver with SG to explain the higher rate of incidences of vitamin B12 deficiency seen in patients post-RYGB relative to patients post-SG...
January 26, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28125303/sugarcane-molasses-a-potential-dietary-supplement-in-the-management-of-iron-deficiency-anemia
#5
Rahi Jain, Padma Venkatasubramanian
Iron deficiency anemia (IDA) is a serious public health problem that debilitates ∼1.6 billion people globally every year, the majority being pregnant women and children from developing countries. In India, for example, in spite of several operational programs at the national level using iron-folic acid and other allopathic interventions, IDA is still prevalent. Traditional medicines, such as Ayurveda, prescribe herbal formulations containing sugarcane derivatives for the management of pandu, a condition similar to IDA...
January 26, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28121473/nephroprotective-and-anti-inflammatory-effects-of-pistacia-atlantica-leaf-hydroethanolic-extract-against-gentamicin-induced-nephrotoxicity-in-rats
#6
Esfandiar Heidarian, Effat Jafari-Dehkordi, Parisa Valipour, Keihan Ghatreh-Samani, Leila Ashrafi-Eshkaftaki
Gentamicin in overdose can lead to tubular injury and kidney dysfunction. Some antioxidants can protect kidneys against nephrotoxicity. This study was undertaken to evaluate the protective effects of Pistacia atlantica (P. atlantica) leaf hydroethanolic extract against gentamicin-induced nephrotoxicity in rats. Forty rats were divided into five groups: the first group received a daily intraperitoneal (i.p.) injection of normal saline. The second group received gentamicin (120 mg/kg, i.p.). The third, fourth, and fifth groups were orally treated with 200, 400, and 800 mg/kg of P...
January 25, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28121470/impact-of-wheatgrass-triticum-aestivum-l-supplementation-on-atherogenic-lipoproteins-and-menopausal-symptoms-in-hyperlipidemic-south-asian-women-a-randomized-controlled-study
#7
Nitya Kumar, Uma Iyer
OBJECTIVE: The purpose of this study was to evaluate the effect of wheatgrass (Triticum aestivum L.) on atherogenic lipoproteins, inflammation, and menopausal symptoms. METHODS: Fifty-nine hyperlipidemic women were randomized into control (n = 30) and intervention groups (n = 29). Intervention group was administered 3.5 g of freeze-dried wheatgrass powder in encapsulated form daily for 10 weeks, while the control group received no intervention. RESULTS: The intervention group experienced a reduction of 5...
January 25, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28139156/nutritional-supplementation-of-donors-may-improve-outcomes-following-the-transfusion-of-stored-red-blood-cells
#8
P B Addis, J A St Cyr
No abstract text is available yet for this article.
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28129002/antidiabetic-and-antioxidant-potentials-of-amaranthus-hybridus-in-streptozotocin-induced-diabetic-rats
#9
T Balasubramanian, M Karthikeyan, K P Muhammed Anees, C P Kadeeja, K Jaseela
CONTEXT: Amaranthus hybridus (Amaranthaceae) has been used as a folk medicine in southern parts of India for the treatment of diabetes. OBJECTIVE: This research evaluates the antidiabetic and antioxidant effects of Amaranthus hybridus ethanol leaf extract (AHELE) in streptozotocin-induced diabetic rats. METHODS: Blood glucose levels of diabetic rats were measured on days 1, 4, 7, and 15 after oral administration of AHELE at doses of 200 and 400 mg/kg for 14 days...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28121472/plasma-creatine-kinetics-after-ingestion-of-microencapsulated-creatine-monohydrate-with-enhanced-stability-in-aqueous-solutions
#10
Michelle Hone, Robert M Kent, Alessandro Scotto di Palumbo, Sinead B Bleiel, Giuseppe De Vito, Brendan Egan
Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28118067/cassava-flour-substitution-modulates-glycemic-responses-and-glycemic-index-of-wheat-breads-in-apparent-healthy-volunteers
#11
Ebelechukwu N Okafor, Ochuko L Erukainure, Augusta U Ozumba, Chris O Adewale, Funmi O Kayode, Godfrey O Asieba, Olubukola I Adesegha, Gloria N Elemo
Different carbohydrate foods produce different glycemic responses even with little or no difference in macronutrient composition. Cassava constitutes one of the major staples in Nigeria. Four blends of cassava-wheat bread samples with 0, 10, 15, and 20% cassava flour inclusion were fed individually to groups of healthy human volunteers. Subjects were studied on separate occasions in the morning after a 10-12-hr overnight fast. Blood glucose responses were measured at intervals of 30 min over a period of 2 hr...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28118062/taurine-supplementation-improves-functional-capacity-myocardial-oxygen-consumption-and-electrical-activity-in-heart-failure
#12
Mehdi Ahmadian, Valiollah Dabidi Roshan, Eadeh Ashourpore
BACKGROUND: Taurine is an amino acid found abundantly in the heart in very high concentrations. It is assumed that taurine contributes to several physiological functions of mammalian cells, such as osmoregulation, anti-inflammation, membrane stabilization, ion transport modulation, and regulation of oxidative stress and mitochondrial protein synthesis. The objective of the current study was to evaluate the effectiveness of taurine supplementation on functional capacity, myocardial oxygen consumption, and electrical activity in patients with heart failure...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28107087/comparison-of-fatty-acid-composition-in-selected-dietary-supplements-containing-conjugated-linoleic-acid
#13
Dorota Derewiaka, Klara Nestorowicz, Rafał Wołosiak
The market of pharmaceutical products is offering a wide range of supplements. Most of the consumers believe that these products will improve their state of health, but are they getting what they want and what they are paying for? The aim of the study was to evaluate the quality of selected dietary supplements containing conjugated linoleic acid (CLA). All supplements were available in the Warsaw markets and bought from pharmacies. Assessment of the quality of food supplements was achieved by analysis of fatty acid using gas chromatography coupled with a mass spectrometer...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28095073/preclinical-and-potential-applications-of-common-western-herbal-supplements-as-complementary-treatment-in-parkinson-s-disease
#14
Luke A Morgan, Oliver Grundmann
Parkinson's disease (PD) is a neurological disorder with a complex pathological etiology, which is not fully understood. Progression of PD may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. Dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. Current medication used in the treatment of PD aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27973970/potential-renoprotective-effects-of-rosemary-and-thyme-against-gentamicin-toxicity-in-rats
#15
Amal S Abdel-Azeem, Amany M Hegazy, Hala M Zeidan, Khadiga S Ibrahim, Eman M El-Sayed
Gentamicin (GM) is a drug used commonly against gram-negative bacteria. Its therapeutic use is mainly limited by its nephrotoxicity. This investigation was aimed at evaluating the nephroprotective effects of rosemary (RM; Rosmarinus officinalis) and thyme (TV; Thymus vulgaris) against GM toxicity. Rats were divided into four groups. Normal control group was treated intraperitoneally (i.p.) with saline; positive control group was administered GM 60 mg/kg/day i.p.; RM group was co-administered 8% RM aqueous extract, 10 mL/kg/day, orally with GM; and TV group was co-administered 8% TV aqueous extract orally, 10 mL/kg/day with GM...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27937000/do-studies-evaluating-qt-qtc-interval-prolongation-with-dietary-supplements-meet-fda-standards-a-systematic-review
#16
Tinh An Nguyen, Amy Kurian, Jessica Leong, Umang M Patel, Sachin A Shah
PURPOSE: Dietary supplement use is continuously increasing, but the safety evaluation of these products remains partial. While dietary supplements have no mandate for assessing cardiovascular safety, all new drug entities (NDE) are required to undergo a thorough QT/corrected QT (QTc) assessment to determine their propensity to impact cardiac repolarization. Independent investigators and manufacturers of dietary supplements voluntarily initiate safety studies; however, the quality of these studies is controversial...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27893282/plant-food-supplements-with-antioxidant-properties-for-the-treatment-of-chronic-and-neurodegenerative-diseases-benefits-or-risks
#17
Luca Piemontese
Wine by-products, in particular grape pomace, can be an important source of polyphenols and dietary fibers and are increasingly being used as a starting material in the industrial production of plant food supplements, such as other matrices containing biomolecules, with antioxidant properties. The risk associated with the consumption of these products was recently analyzed through a study of potential genotoxic and carcinogenic compounds that can be found in the marketed products. In particular, occurrence data about contamination with the mycotoxin ochratoxin A were also reported...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27813677/muscle-carnosine-concentration-with-the-co-ingestion-of-carbohydrate-with-%C3%AE-alanine-in-male-rats
#18
Alireza Naderi, Mehdi Sadeghi, Amir Sarshin, Vahid Imanipour, Seyed Ali Nazeri, Fatemeh Farkhayi, Mark E T Willems
Muscle carnosine is an intracellular buffer. The intake of β-alanine, combined with carbohydrate and protein, enhanced carnosine loading in human muscle. The aim of the present study was to examine if muscle carnosine loading was enhanced by β-alanine intake and co-ingestion of glucose in male rats. Thirty-six male rats were divided into three groups and supplemented for four weeks: β-alanine (βA group, 1.8% β-alanine in drinking water), β-alanine and glucose (βAGL group, 1.8% β-alanine and 5% glucose in drinking water), and control (C group, drinking water)...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27753518/phenolic-extracts-from-clerodendrum-volubile-leaves-inhibit-cholinergic-and-monoaminergic-enzymes-relevant-to-the-management-of-some-neurodegenerative-diseases
#19
Ganiyu Oboh, Omodesola O Ogunruku, Sunday I Oyeleye, Tosin A Olasehinde, Ayokunle O Ademosun, Aline Augusti Boligon
This study investigated the inhibitory effects of phenolic-rich extracts from Clerodendrum volubile leaves on cholinergic [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] and monoaminergic [monoamine oxidase (MAO)] enzymes' activities and pro-oxidants [Fe(2+) and quinolinic acid-(QA)] induced lipid peroxidation in rats brain homogenates in vitro. Free phenolic extracts (FPE) and bound phenolic extracts (BPE) were obtained via solvent extraction, and the total phenol and flavonoid contents were evaluated...
May 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27736246/the-effect-of-green-tea-and-sour-tea-hibiscus-sabdariffa-l-supplementation-on-oxidative-stress-and-muscle-damage-in-athletes
#20
Amir Hadi, Makan Pourmasoumi, Marzieh Kafeshani, Jahangir Karimian, Mohammad Reza Maracy, Mohammad Hasan Entezari
OBJECTIVE: Additional oxygen consumption during intense exercises may lead to oxidative stress and contribute to muscular fatigue. Green tea and sour tea (Hibiscus sabdariffa L.), which contain various flavonoids and polyphenols, have many healthful properties such as anticarcinogenic, anti-inflammatory, and heart protecting effects. The aim of the present study was to assess the effects of green tea and sour tea supplementation on oxidative stress and muscle damage in soccer athletes...
May 4, 2017: Journal of Dietary Supplements
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