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BMC Veterinary Research

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https://www.readbyqxmd.com/read/28633676/evaluation-of-p16-expression-in-canine-appendicular-osteosarcoma
#1
B G Murphy, M Y Mok, D York, R Rebhun, K D Woolard, C Hillman, P Dickinson, K Skorupski
BACKGROUND: Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even with aggressive surgical treatment combined with chemotherapy, the majority of dogs diagnosed with OSA live less than 1 year from the time of diagnosis. The ability to identify canine OSA cases most responsive to treatment is needed. In humans, OSA is also an aggressive tumor that is histologically and molecularly similar to canine OSA...
June 20, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629460/interaction-between-pasteurella-multocida-b-2-and-its-derivatives-with-bovine-aortic-endothelial-cell-baec
#2
Nuriqmaliza M Kamal, M Zamri-Saad, Mas Jaffri Masarudin, Sarah Othman
BACKGROUND: Pasteurella multocida B:2 causes bovine haemorrhagic septicaemia (HS), leading to rapid fatalities in cattle and buffaloes. An attenuated derivative of P. multocida B:2 GDH7, was previously constructed through mutation of the gdhA gene and proved to be an effective live attenuated vaccine for HS. Currently, only two potential live attenuated vaccine candidates for HS are being reported; P. multocida B:2 GDH7 and P. multocida B:2 JRMT12. This study primarily aims to investigate the potential of P...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629456/comparison-of-the-effects-of-7-2-hypertonic-saline-and-20-mannitol-on-whole-blood-coagulation-and-platelet-function-in-dogs-with-suspected-intracranial-hypertension-a-pilot-study
#3
Ivayla D Yozova, Judith Howard, Diana Henke, Daniel Dirkmann, Katja N Adamik
BACKGROUND: Hyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629451/metabolic-response-to-three-different-diets-in-lean-cats-and-cats-predisposed-to-overweight
#4
Claudia Keller, Annette Liesegang, Diana Frey, Brigitta Wichert
BACKGROUND: The existence of a genetic predisposition to obesity is commonly recognized in humans and rodents. Recently, a link between genetics and overweight was shown in cats. The goal of this study was to identify the effect of diet composition on plasma levels of glucose, insulin, free fatty acids and triglycerides in cats receiving different diets (high-carbohydrate, high-fat and high-protein diets). RESULTS: Insulin and leptin concentrations were significantly correlated with phenotype...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629420/comparison-of-the-effects-of-platelet-rich-or-growth-factor-rich-plasma-on-intestinal-anastomosis-healing-in-pigs
#5
Gessica Giusto, Cristina Vercelli, Selina Iussich, Massimiliano Tursi, Giovanni Perona, Marco Gandini
BACKGROUND: The use of autologous platelet-rich plasma (PRP) and plasma rich in growth factors (PRGF) has been proposed for the treatment of several acute and chronic syndromes, such as corneal epithelial defects and dry eye syndrome, gum bleeding during oral surgery, and in orthopaedic surgery. We hypothesized that PRGF, rather than PRP, could be more effective because of its intrinsic characteristics in promoting the healing of intestinal anastomosis. The purpose of the present study was to evaluate and compare the effects of PRP and PRGF on various parameters of anastomotic healing in a swine model...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629414/fibrinogen-deficiency-in-a-dog-a-case-report
#6
Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat, Olivier Dossin
BACKGROUND: Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs. There are, however, no published case reports of primary hypofibrinogenemia in dogs. CASE PRESENTATION: A 1.5 year-old male German Pointer dog was evaluated for a locked-jaw syndrome associated with eye protrusion which appeared after a minor head trauma...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629406/geospatial-and-temporal-associations-of-getah-virus-circulation-among-pigs-and-horses-around-the-perimeter-of-outbreaks-in-japanese-racehorses-in-2014-and-2015
#7
Hiroshi Bannai, Manabu Nemoto, Hidekazu Niwa, Satoshi Murakami, Koji Tsujimura, Takashi Yamanaka, Takashi Kondo
BACKGROUND: We studied a recent epizootic of Getah virus infection among pigs in the southern part of Ibaraki Prefecture and the northern part of Chiba Prefecture, Japan, focusing on its possible association with outbreaks in racehorses in 2014 and 2015. The genomic sequence of a Getah virus strain from an infected pig was analyzed to evaluate the degree of identity with the strains from horses. RESULTS: Sera were collected from pigs from September to December 2012 to 2015 in south Ibaraki (380 pigs in 29 batches), and from September to December 2010 to 2015 in north Chiba (538 pigs in 104 batches)...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28629364/changes-in-concentrations-of-haemostatic-and-inflammatory-biomarkers-in-synovial-fluid-after-intra-articular-injection-of-lipopolysaccharide-in-horses
#8
Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T Kristensen, Stine Jacobsen
BACKGROUND: Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28623934/serological-and-virological-surveillance-of-avian-influenza-virus-in-domestic-ducks-of-the-north-east-region-of-bangladesh
#9
Rahul Deb Sarker, Mohammad Giasuddin, Emdadul Haque Chowdhury, Mohammad Rafiqul Islam
BACKGROUND: Wild waterfowl are considered as the natural reservoir for avian influenza (AI) viruses. Bangladesh has been experiencing highly pathogenic avian influenza (HPAI) outbreaks since 2007, mostly in chickens and occasionally in ducks. Ducks play an important role in the persistence and genetic recombination of AI viruses. This paper presents the results of serological and virological monitoring of AI in domestic ducks in 2013 in the north-east region of Bangladesh. RESULTS: A total of 871 and 662 serum samples and 909 and 302 pairs of cloacal and oropharyngeal swabs from domestic ducks of Mymensingh and Sylhet division, respectively, were analysed...
June 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28623924/in-vitro-physiological-and-antibacterial-characterization-of-zno-nanoparticle-composites-in-simulated-porcine-gastric-and-enteric-fluids
#10
Marina S R Barreto, Cristina T Andrade, Luiz Cláudio R P da Silva, Lúcio M Cabral, Vânia M Flosi Paschoalin, Eduardo M Del Aguila
BACKGROUND: Diarrhea in piglets is one of the main causes of animal death after weaning; zinc oxide (ZnO) has been used in high doses for the control of this sickness. The aim of this study was to determine the physicochemical properties of ZnO nanoparticles synthesized and immobilized on a chitosan/alginate (CH/SA) complex and investigate the antimicrobial activity and in vitro release profile of zinc (Zn(2+)) from these new compounds. The ZnO nanoparticles composites were prepared and combined with CH/SA or CH/SA and sodium tripolyphosphate (TPP)...
June 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28623915/safety-pharmacology-and-subchronic-toxicity-of-jinqing-granules-in-rats
#11
Xuerong Zhou, Qian Rong, Min Xu, Yuanli Zhang, Qi Dong, Yuanling Xiao, Qiji Liu, Helin Chen, Xiaoyu Yang, Kaisheng Yu, Yinglun Li, Ling Zhao, Gang Ye, Fei Shi, Cheng Lv
BACKGROUND: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. RESULTS: In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems...
June 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28619095/integrated-pharmacokinetic-pharmacodynamic-pk-pd-model-to-evaluate-the-in-vivo-antimicrobial-activity-of-marbofloxacin-against-pasteurella-multocida-in-piglets
#12
Qing Lin Zeng, Xian Mei, Jia Su, Xiao Hong Li, Wen Guang Xiong, Yan Lu, Zhen Ling Zeng
BACKGROUND: Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it's in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. A series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with P. multocida type B, serotype 2. RESULTS: The ratio of the 24 h area under the concentration-time curve divided by the minimum inhibitory concentration (AUC24TCF/MIC) was the best PK/PD index correlated with the in vivo antibacterial effectiveness of marbofloxacin (R2 = 0...
June 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28619055/molecular-typing-of-leptospira-interrogans-serovar-hardjo-isolates-from-leptospirosis-outbreaks-in-brazilian-livestock
#13
Maria Raquel V Cosate, Tetsu Sakamoto, Tiago Antônio de Oliveira Mendes, Élvio C Moreira, Carlos G Regis da Silva, Bruno S A F Brasil, Camila S F Oliveira, Vasco Ariston de Azevedo, José Miguel Ortega, Rômulo C Leite, João Paulo Haddad
BACKGROUND: Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira spp. This zoonotic disease is distributed globally and affects domestic animals, including cattle. Leptospira interrogans serogroup Sejroe serovar Hardjo and Leptospira borgpetersenii serogroup Sejroe serovar Hardjo remain important species associated with this reproductive disease in livestock production. Previous studies on Brazilian livestock have reported that L. interrogans serovar Hardjo is the most prevalent leptospiral agent in this country and is related to clinical signs of leptospirosis, which lead to economic losses in production...
June 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28615070/a-randomised-clinical-trial-of-a-metaphylactic-treatment-with-tildipirosin-for-bovine-respiratory-disease-in-veal-calves
#14
J Berman, D Francoz, J Dubuc, S Buczinski
BACKGROUND: Bovine respiratory disease (BRD) is a major problem in veal calf rearing units. The objective of this randomised clinical trial was to assess the effectiveness of tildipirosin as a metaphylactic treatment in veal calves on the number of BRD treatments, lung consolidation on thoracic ultrasonography (TUS) and average daily gain (ADG). A total of 209 veal calves from a pre-weaning fattening unit were randomly allocated to receive one of two treatments (tildipirosin 4 mg/kg, subcutaneously, n = 109; placebo 0...
June 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28615055/small-sized-newborn-dogs-skeletal-development-radiologic-morphometric-and-histological-findings-obtained-from-spontaneously-dead-animals
#15
S C Modina, M C Veronesi, M Moioli, T Meloni, G Lodi, V Bronzo, M Di Giancamillo
BACKGROUND: Very little is known about neonatal skeletal development in small-sized purebred dogs. In order to improve this knowledge, 27 spontaneously dead puppies belonging to small-sized breeds were enrolled in this study for radiologic, histological and morphometric investigations. RESULTS: The appearance of the limb secondary ossification centers and the onset of their formation were clearly observed by x rays and confirmed by histological evidences. Radiographic and anatomic measurements of limb bones length and skull length and width were positively correlated with body weight and age of the subjects and the body weight was positively correlated with radius bone mineral density, as demonstrated by dual-energy x-rays absorptiometry...
June 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28610629/the-use-of-imepitoin-pexion%C3%A2-on-fear-and-anxiety-related-problems-in-dogs-a-case-series
#16
Kevin J McPeake, Daniel S Mills
BACKGROUND: Fear and anxiety based problems are common in dogs. Alongside behaviour modification programmes, a range of psychopharmacological agents may be recommended to treat such problems, but few are licensed for use in dogs and the onset of action of some can be delayed. The low affinity partial benzodiazepine receptor agonist imepitoin (Pexion™, Boehringer Ingelheim) is licensed for treating canine epilepsy, has a fast onset of action in dogs and has demonstrated anxiolytic properties in rodent models...
June 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28610617/stimulating-collaboration-between-human-and-veterinary-health-care-professionals
#17
Björn G M Eussen, Jaap Schaveling, Maria J Dragt, Robert Jan Blomme
BACKGROUND: Despite the need to control outbreaks of (emerging) zoonotic diseases and the need for added value in comparative/translational medicine, jointly addressed in the One Health approach [One health Initiative (n.d.a). About the One Health Initiative. http://www.onehealthinitiative.com/about.php . Accessed 13 September 2016], collaboration between human and veterinary health care professionals is limited. This study focuses on the social dilemma experienced by health care professionals and ways in which an interdisciplinary approach could be developed...
June 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28606148/development-of-a-stochastic-agent-based-model-to-evaluate-surveillance-strategies-for-detection-of-emergent-porcine-reproductive-and-respiratory-syndrome-strains
#18
A G Arruda, Z Poljak, D Knowles, A McLean
BACKGROUND: The objective of the current study was to develop a stochastic agent-based model using empirical data from Ontario (Canada) swine sites in order to evaluate different surveillance strategies for detection of emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains at the regional level. Four strategies were evaluated, including (i) random sampling of fixed numbers of swine sites monthly; (ii) risk-based sampling of fixed numbers, specifically of breeding sites (high-consequence sites); (iii) risk-based sampling of fixed numbers of low biosecurity sites (high-risk); and (iv) risk-based sampling of breeding sites that are characterized as low biosecurity sites (high-risk/high-consequence)...
June 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28606140/imepitoin-is-well-tolerated-in-healthy-and-epileptic-cats
#19
Odilo Engel, Thilo von Klopmann, Arianna Maiolini, Jessica Freundt-Revilla, Andrea Tipold
BACKGROUND: Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats. The aim of this study was to collect tolerability data and first exploratory efficacy data of imepitoin in both healthy and epileptic cats. RESULTS: In two tolerability studies, 30 healthy cats received imepition twice daily in doses of 0, 30, 40 or 80 mg/kg bodyweight for 30 days...
June 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28599670/whole-genome-sequencing-of-an-expec-that-caused-fatal-pneumonia-at-a-pig-farm-in-changchun-china
#20
Ling-Cong Kong, Xia Guo, Zi Wang, Yun-Hang Gao, Bo-Yan Jia, Shu-Ming Liu, Hong-Xia Ma
BACKGROUND: In recent years, highly frequent swine respiratory diseases have been caused by extraintestinal pathogenic Escherichia coli (ExPEC) in China. Due to this increase in ExPECs, this bacterial pathogen has become a threat to the development of the Chinese swine industry. To investigate ExPEC pathogenesis, we isolated a strain (named SLPE) from lesioned porcine lungs from Changchun in China, reported the draft genome and performed comparative genomic analyses. RESULTS: Based on the gross post-mortem examination, bacterial isolation, animal regression test and 16S rRNA gene sequence analysis, the pathogenic bacteria was identified as an ExPEC...
June 9, 2017: BMC Veterinary Research
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