Ana Cláudia Dumont Oliveira, Carolina Menezes Suassuna de Souza, Eduardo Milton Ramos-Sanchez, Soraia Araújo Diniz, Ewerton de Souza Lima, Maiara Garcia Blagitz, Robson Cavalcante Veras, Marcos Bryan Heinemann, Alice Maria Melville Paiva Della Libera, Sarne De Vliegher, Artur Cezar de Carvalho Fernandes, Fernando Nogueira Souza
BACKGROUND: The periparturient period in dairy cows is marked by immunosuppression which increases the likelihood of infectious disorders, particularly also mastitis. An in-depth understanding of peripartum leukocyte biology is vital for the implementation of highly successful post-partum disease prevention measures. Immune checkpoint molecules, such as programmed death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4), are critical inhibitory receptors expressed on immune cells, particularly T cells, that drive immunosuppressive signaling pathways...
April 20, 2024: BMC Veterinary Research