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Journal of Cancer Research and Therapeutics

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https://www.readbyqxmd.com/read/28643769/oral-cryotherapy-for-preventing-chemotherapy-induced-oral-mucositis-an-effective-but-yet-neglected-strategy
#1
LETTER
Hassan Sharifi, Abbas Heydari, Roham Salek, Amir Emami Zeydi
No abstract text is available yet for this article.
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643768/adult-rhabdomyosarcoma-multimodality-management-and-results
#2
LETTER
Abhijeet Ashok Salunke, Jaymin Shah, Nayan Gupta, Jyotindra Pandit
No abstract text is available yet for this article.
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643767/significant-plasmacytosis-in-an-early-induction-marrow-of-acute-myeloid-leukemia-diagnostic-and-therapeutic-implications
#3
LETTER
Namrata Punit Awasthi, Sumaira Qayoom, Ankita Jaiswal, Sunil Dabadghao
No abstract text is available yet for this article.
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643766/complexity-of-chromosomal-rearrangements-in-down-syndrome-leukemia
#4
LETTER
Bani Bandana Ganguly, Nitin N Kadam, Prakash K Mandal
Reports on imbalanced HSA21 gene expression and chromosomal rearrangements on leukemogenesis, drug sensitivity, and treatment outcome of leukemia in Down syndrome (DS) are limited. DS has been recognized as one of the most common leukemia-predisposing syndromes with unique clinical features, significant differences in treatment outcome and treatment-related toxicity profiles. Acute myeloid leukemia (AML), especially acute megakaryocytic leukemia, is reported with high cure rates presenting 80%-100% event-free survivals (EFSs); however, acute lymphoid leukemia indicates a worse prognosis in DS patients compared to non-DS children...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643765/intrapancreatic-mass-a-rare-cause
#5
LETTER
Maximilian Sohn, Martin Fuchs, Helmut Rohrbach, Igors Iesalnieks, Ayman Agha, Friederieke Liesche
We found a case of pancreatic extraintestinal gastrointestinal stroma tumor (pEGIST) in 2014. The patient, initially suspected to suffer from pancreatic adenocarcinoma, underwent open left hemipancreatectomy and en bloc splenectomy in May 2014. Postoperative histopathology showed the unexpected manifestation of a pEGIST. Recovery was well, and a 23-month follow-up was free from recurrency by now.
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643764/clear-cell-odontogenic-carcinoma-a-rare-case-report-with-emphasis-on-differential-diagnosis
#6
LETTER
Uma Vasant Datar, Mamata Sharad Kamat, Sampada Shriram Kanitkar, Sanjay Satappa Byakodi
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic malignancy with a female predilection, typically presenting as swelling in anterior region of mandible. CCOC was classified as a malignant neoplasm of odontogenic origin by the WHO in 2005 as it exhibits an aggressive growth pattern, local recurrence, and tendency of distant metastasis. Histologically, CCOC is characterized by sheets and islands of vacuolated/clear cells. Since clear cells are present in few odontogenic tumors, salivary gland neoplasms, and metastatic tumors to the jaws; presence of clear cells in a lesion of head and neck area poses a diagnostic challenge...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643763/bowen-s-disease-two-case-reports-of-a-giant-and-dwarf-lesions
#7
LETTER
Sundar Nagakeerthana, Gurumoorthy Rajesh, Sankar Madhavi, Kaliaperumal Karthikeyan
Bowen's disease is a form of intraepidermal squamous cell carcinoma (SCC). It usually presents as a well-demarcated, slow growing erythematous patch, or plaque with a scaly or crusted surface. The size of the tumor varies from a few millimeters to several centimeters. The risk of progression into an invasive carcinoma is 3-5% in extragenital lesions and about 10% in genital lesions. We present two cases of Bowen's disease where the pattern, size, and perception of the disease between the patients varied. The two cases demonstrated two varying spectrum of the disease, one being a giant lesion and other a dwarf...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643762/serum-butyrylcholinesterase-and-zinc-in-breast-cancer
#8
Rupesh Kumar, Sairoz Razab, Krishnananda Prabhu, Satadru Ray, Bhanu Prakash
CONTEXT: Even though, a large number of serological, molecular markers have been proposed for breast cancer screening, most of them lack specificity, sensitivity, prognostic value, and cost effectiveness. Butyrylcholinesterase (BChE) and its genes are aberrantly expressed in a variety of human cancers. It has-been linked to tumorigenesis, cell proliferation, and cell differentiation. Zinc (Zn) is a cofactor for superoxide dismutase, an enzyme that protects cellular components against free radical-induced damage and carcinogenesis...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643761/the-effects-of-gene-therapy-with-granulocyte-macrophage-colony-stimulating-factor-in-the-regression-of-tumor-masses-in-fibrosarcoma-mouse-model
#9
Saiedeh RaziSoofiyani, Tohid Kazemi, Farzaneh Lotfipour, Leila Mohammadnejad, Somayeh Hallaj-Nezhadi, Siamak Sandoghchian Shotorbani, Akbar Mohammad Hosseini, Behzad Baradaran
INTRODUCTION: Cytokine gene therapy is one of the cancer treatment strategies. Recently, granulocyte-monocyte colony-stimulating factor (GM-CSF), as an important cytokine in activating dendritic cells and boosting the anti-tumor immune responses, has been utilized as an immunotherapeutic agent in cancer gene therapy. The purpose of the present investigation was to study the GM-CSF gene therapy effects in regression of tumor masses in fibrosarcoma mouse model. MATERIALS AND METHODS: To investigate the therapeutic efficacy of GM-CSF, WEHI-164 tumor cells were transfected with murine GM-CSF plasmid...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643760/validation-of-microsatellite-instability-histology-scores-with-bethesda-guidelines-in-hereditary-nonpolyposis-colorectal-cancer
#10
Mustafa Kaya, Fatih Basak, Abdullah Sisik, Mustafa Hasbahceci, Gurhan Bas, Orhan Alimoglu, Cumhur Sel├žuk Topal, Gozde Kir
AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) is a subgroup of colorectal cancer (CRC) which should be differentiated because of the high risk for additional cancers and risk evaluation for other family members, especially for CRC. It is not practical to perform genetic testing for all CRC patients; therefore, various prediction modalities, for example, Bethesda guideline (BG) were studied in the literature. We aimed to assess the association of microsatellite instability (MSI), histology scores, and BG for predicting HNPCC risk...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643759/overall-treatment-duration-with-multimodality-treatment-approach-and-outcome-results-in-oral-cavity-carcinoma-a-study-from-an-institute-from-central-india
#11
Vandana Jain, Digpal Dharkar, Hamsa Nandini, Shailendra M Jain
OBJECTIVE OF THE STUDY: To see the different age groups, gender, sites, disease stage, treatment outcome of various oral cavity sites carcinoma by combined modalities and the overall treatment duration. MATERIALS AND METHODS: A total of 212 oral cavity carcinoma patients (169 males and 43 females) with complete records (from September 2009 to December 2012) were analyzed for age, sex, histopathology, associated medical illnesses, various subsites with disease stage, various treatment modalities with the duration and follow-up records for disease control as well as disease failure at local, nodal, local + nodal, and distant metastasis...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643758/effects-of-ef-24-rad001-and-paclitaxel-on-the-expression-profiles-of-apoptotic-and-anti-apoptotic-genes
#12
Ebru Alp, Akin Yilmaz, Hacer Ilke Onen, Emine Sevda Menevse
CONTEXT: Cancer cells exert differential responses to chemotherapeutics and inhibitors. To the best of our knowledge, a few or no research has been performed until now to determine the effect of EF-24 and RAD001 on MDA-MB-231 breast cancer cells with regard to mRNA expression of apoptotic and anti-apoptotic genes. AIMS: In this study, we aimed to investigate the mRNA expression levels of apoptotic (caspase 2 [CASP2], CASP8, and CASP9) and anti-apoptotic (B-cell lymphoma 2 [BCL2] and BCL2-like protein 1 [BCL2L1]) genes after exposure to paclitaxel, EF-24, and RAD001 in MDA-MB-231 cells...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643757/significance-of-expression-of-suppressor-of-cytokine-signaling-proteins-suppressor-of-cytokine-signaling-1-suppressor-of-cytokine-signaling-2-and-suppressor-of-cytokine-signaling-3-in-papillary-thyroid-cancer
#13
Toral Pundrik Kobawala, Trupti I Trivedi, Kinjal Kevin Gajjar, Girish H Patel, Nandita R Ghosh
PURPOSE: Uncontrolled cytokine signal transduction largely associated with oncogene activation, can have disastrous biological consequences. The suppressor of cytokine signaling (SOCS) proteins represent one of the mechanisms by which this rampant signaling can be dissipated. Thus, we aimed to study the expression of SOCS-1, SOCS-2, and SOCS-3 in patients having benign thyroid disease and papillary thyroid cancer. MATERIALS AND METHODS: SOCS protein expression was studied in 45 patients with benign thyroid disease and in 83 papillary thyroid cancer patients by immunohistochemistry and their association with clinicopathological characteristics and overall survival in cancer patients were analyzed using SPSS software...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643756/is-neuroglial-antigen-2-a-potential-contributor-to-cilengitide-response-in-glioblastoma
#14
Hatice Sevim Nalkiran, Kerrie Leanne McDonald
BACKGROUND: Determining the expression levels of neuroglial antigen 2 (NG2) in glioma cell lines and to evaluate the potential contribution of NG2 to cilengitide response were aimed. MATERIALS AND METHODS: Endogenous expression level of NG2 was determined using quantitative reverse transcription polymerase chain reaction and immunoblotting. Cilengitide responses of the cells were monitored to determine half maximal inhibitory concentration values. Whether the suppression of NG2 expression alters the response of A172 cells to cilengitide was examined...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643755/prognostic-significance-of-tumor-volume-as-determined-on-3d-ultrasound-scan-in-uterine-cervix-cancer-treated-by-radiotherapy
#15
Shelly Srivastava, Surendra Kumar Saini, Awadhesh Kumar Dixit, Deepti Dwivedi
AIMS: The aim of this prospective study is to evaluate prognostic significance of tumor volume determined by three-dimensional (3D) ultrasound scan in uterine cervix cancer patients treated by radiotherapy. PATIENTS AND METHODS: A total of 67 patients of Stage IB2-IIIB were studied and analyzed. Cervical tumor volume was determined by 3D ultrasound scan. Two groups were made on the basis of volume on ultrasound scan (Group 1 <40 cc = 36 and Group 2 >40 cc = 31)...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643754/awareness-of-cervical-cancer-and-willingness-to-participate-in-screening-program-public-health-policy-implications
#16
Somdatta Patra, Madhu Upadhyay, Pragti Chhabra
BACKGROUND: Cervical cancer is one of the most common malignancies among women in India. There is a high mortality as patients usually present at an advanced stage because of lack of awareness and nonexistent screening programs. AIM: This study was planned to find out awareness about cervical cancer among women and their willingness to utilize screening services in an urban resettlement colony of Delhi, India. SETTINGS AND DESIGN: A community-based, cross-sectional study was carried out in a resettlement colony of North-West Delhi...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643753/dosimetric-characteristic-of-physical-wedge-versus-enhanced-dynamic-wedge-based-on-monte-carlo-simulations
#17
Seied Rabie Mahdavi, Ghazale Geraily, Ahmad Mostaar, Arman Zia, Golbarg Esmaili, Somayeh Farahani
AIM OF STUDY: Physical wedges (PWs) are widely used in radiotherapy to obtain tilted isodose curves, but they alter beam quality. Dynamic wedges (DWs) using moving collimator overcome this problem, but measuring their beam data is not simple. The main aim of this study is to obtain all dosimetric parameters of DWs produced by Varian 2100CD with Monte Carlo simulation and compare them to those from PWs. SUBJECTS AND METHODS: To simulate 6 MV photon beams equipped with PW and DW, BEAMnrc code was used...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643752/dosimetric-characterization-of-optically-stimulated-luminescence-dosimeter-with-therapeutic-photon-beams-for-use-in-clinical-radiotherapy-measurements
#18
Retna Ponmalar, Ravikumar Manickam, K M Ganesh, Sathiyan Saminathan, Arun Raman, Henry Finlay Godson
AIM: The modern radiotherapy techniques impose new challenges for dosimetry systems with high precision and accuracy in in vivo and in phantom dosimetric measurements. The knowledge of the basic characterization of a dosimetric system before patient dose verification is crucial. This incites the investigation of the potential use of nanoDot optically stimulated luminescence dosimeter (OSLD) for application in radiotherapy with therapeutic photon beams. MATERIALS AND METHODS: Measurements were carried out with nanoDot OSLDs to evaluate the dosimetric characteristics such as dose linearity, dependency on field size, dose rate, energy and source-to-surface distance (SSD), reproducibility, fading effect, reader stability, and signal depletion per read out with cobalt-60 (60 Co) beam, 6 and 18 MV therapeutic photon beams...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643751/quick-efficient-and-effective-patient-specific-intensity-modulated-radiation-therapy-quality-assurance-using-log-file-and-electronic-portal-imaging-device
#19
Rajesh Kumar, H I Amols, M Lovelock, S D Sharma, D Datta
AIM: The aim of work is to explore a quick, efficient, and effective patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA). MATERIALS AND METHODS: Software tools were developed to extract and analyze the multi-leaf collimator (MLC) leaf positions (LPs) from electronic portal imaging device (EPID) images for Varian C-series machine and TrueBeam, to extract useful data from MLC log file of C-series linear accelerator (LINAC), to extract useful information from the trajectory log binary file of TrueBeam LINAC, to compare LPs derived from EPID images with log file/trajectory log data, and to analyze IMRT treatment files using the MATLAB programming language...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643750/evaluation-of-clinical-process-in-osteosarcoma-patients-treated-with-chemotherapy-including-cisplatin-adriamycin-ifosfamide-and-etoposide-and-determination-of-the-treatment-sequels-in-a-long-term-11-year-follow-up
#20
Mozaffar Aznab, Maryam Hematti
AIM: The aim of this study was to evaluate the effect of adding etoposide and ifosfamide chemotherapy drugs to treatment regimen of patients affected with osteosarcoma and to determine the clinical process and response to treatment during a follow-up period of 11 years. MATERIALS AND METHODS: Forty patients with osteosarcoma participated in this study from July 2005 to 2016. Treatments were started based on the following schema and after initial examinations including biochemical profile, checking for lung metastasis by simple radiography, chest computed tomography scan, and bones scan...
April 2017: Journal of Cancer Research and Therapeutics
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