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Journal of Cancer Research and Therapeutics

Zhao Yongfu, Li Ziyu, Liu Chen, Xu Jingchao
Occult thyroid carcinoma is mostly discovered by autopsy or by other causes of thyroid surgery. To the best of our knowledge, there have been only a few reports concerning the situation that cervical mass was the initial manifestation of occult papillary thyroid carcinoma. The three patients in our report were all admitted to hospital because of the masses on their necks. Although pathology reports showed the nodal presence of thyroid cancer, we did not find the primary tumor on the same side of thyroid. We reported the clinical data of patients, including chief complaint, ultrasonography, computed tomography, and pathology results...
June 2018: Journal of Cancer Research and Therapeutics
Lei Jin, Hong-Yu Yang, Yu-Fan Wang, Hui-Jun Yang
Adult fibrosarcoma (FS) of the maxillary sinus and the cranial base is a rare soft tissue sarcoma which is clinically characterized by a high frequency of local repeated recurrence if not excised widely. At present, the standard treatment option for FS is surgical resection. Here, we report a case of a 46-year-old male with a 5 months history recurrent FS of the maxillary sinus. The patient possessed an enormous mass in the right maxillofacial region extending to the cranial base, as observed by computed tomography...
June 2018: Journal of Cancer Research and Therapeutics
Su Chen, Naixiang Huang
The objective of the study was to highlight the significance of surgical treatment for esophageal carcinoma after distal gastrectomy and provide suitable surgical options. A patient with esophageal carcinoma and previous distal partial gastrectomy was treated by replacing the esophagus with remnant stomach and moving the spleen into the thoracic cavity. We then systematically reviewed the literature on the treatment of such conditions. Postoperative recovery went well. During the 2-year follow-up, the patient did not complain any discomfort and had no signs of metastasis or recurrence...
June 2018: Journal of Cancer Research and Therapeutics
Mustafa Karaca, Hakan Kocoglu, Irem Bilgetekin, Ahmet Ozet, Hayriye Sahinli, Hacer Demir, Aykut Kankoc, Deniz Tural, Orhan Kemal Yucel
Cardiac side effects of targeted chemotherapy agents are getting more and more important topic nowadays. However, the studies on this topic are limited. Because multiple agent chemotherapy is not a common treatment option, it is hard to establish controlled study groups (as before chemotherapy and after chemotherapy); further, cancer, itself, may cause cardiac side effects and uncertainty of the symptoms may be associated with previous clinical situation before chemotherapy. For all that, we may get information to a certain degree about the side effects of these agents by analyzing case reports...
June 2018: Journal of Cancer Research and Therapeutics
Ying Zhang, Xiaochun Huang, Chuangliang Peng, Yongbin Wang, Qian Wu, Zhen Wu, Hongyan Shao, Wei Wang
Primary pulmonary epithelioid angiosarcoma is an extremely rare malignancy. Herein, we report the case of an elderly Chinese patient with primary pulmonary epithelioid angiosarcoma. The 72-year-old man presented with a 1-month history of persistent hemoptysis and left chest pain and weight loss of 3 kg. A chest computed tomography (CT) scan revealed two masses (maximum size 3.0 cm × 2.0 cm and 0.8 cm × 0.5 cm) in right lower lobe. We performed a left thoracotomy for tumor resection. Pathological examination showed that there was a significant amount of hemorrhage, fibrinous exudates, degeneration, and necrosis...
June 2018: Journal of Cancer Research and Therapeutics
Yanli Zhang, Suiliang Zhang, Wei Xia, Zhiyong Dong
Aim of the Study: Results on the relationship between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G (rs231775) gene polymorphism and colorectal cancer risk are still debated. This meta-analysis was performed to assess the association between CTLA4 +49A/G and colorectal cancer risk. Materials and Methods: The relevant studies were searched from PubMed, Cochrane Library, and China Biological Medicine Database-disc, and eligible investigations were included and synthesized using meta-analysis method...
June 2018: Journal of Cancer Research and Therapeutics
Kai He, Xiaolan Yu, Xiaoyan Wang, Li Tang, Yong Cao, Jiyi Xia, Jinnan Cheng
Aim: The aim of this study is to investigate the mechanism of baicalein in inducing human liver cell line SMMC-7721 apoptosis. Materials and Methods: Twenty micromoles baicalein or 10 μM LY294002 was adopted to treat SMMC-7721 cells. Cell proliferation was tested by cell counting kit-8 assay. Cell cycle was determined by flow cytometry and cyclin D1 expression. Cell apoptosis was detected by annexin V/propidium iodide double staining. Phosphatidyl inositol 3-kinase (PI3K)/Akt signaling pathway was assessed by real-time polymerase chain reaction and Western blot...
June 2018: Journal of Cancer Research and Therapeutics
Da-Dong Wang, Wei-Dong Duan, Zi-Man Zhu, Yu-Liang Tu, Chun-Qing Dou, Ming-Ming Han, Bao Zhang, Wei Zhao, Kai Jiang
Aims: Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship. Materials and Methods: Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis). Results: We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models...
June 2018: Journal of Cancer Research and Therapeutics
Min Hang Zhou, Zhi Hong Wang, Hong Wei Zhou, Mo Liu, Yong Jian Gu, Jun Zhong Sun
Objective: Cancer patients with bone marrow metastases are rare and dismal. The study was to identify the clinical features and prognostic factors in cancer patients with bone marrow metastases. Patients and Methods: A total of 30 patients with bone marrow metastases were reviewed between September 2007 and September 2013. Bone marrow metastases were identified by bone marrow aspiration. Results: The median age was 56.5 years (range, 8-85 years)...
June 2018: Journal of Cancer Research and Therapeutics
Di Wu, Jiankuo Du, Yan Zhang, Yunming Su, Hongfeng Zhang
Aim: This study was conducted to investigate the anti-tumor effects of the Chinese traditional herb phenolic alkaloids of menispermum dauricum (PAMD) on gastric cancer both in vitro and in vivo. Materials and Methods: Cell apoptosis was detected in cultured SGC-7901 cells after administration of a different dose of PAMD. Gastric cancer model was established by single i.p. injection of SGC-7901 cells in the mice (n = 60). Then, animals were received high dose (20 mg/kg), medial dose (10 mg/kg), and low dose (5 mg/kg) of PAMD...
June 2018: Journal of Cancer Research and Therapeutics
Jiaxuan Qin, Fanping Meng, Zhilin Chu, Xinquan Gu
Background/Objective: It has been reported that Krüppel like factor 6 intervening sequence (KLF6 IVS) 1-27 G > A might be associated with cancer susceptibility. Here, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods/Main Results: A systematic search of studies on the association between KLF6 IVS 1-27 G > A, and cancer susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size...
June 2018: Journal of Cancer Research and Therapeutics
Hyun Goo Kim, Sang Uk Woo, Hoon Yub Kim, Gil Soo Son, Jae Bok Lee, Jeong Won Bae, Ok Hee Woo, Dae Sik Yang, Jae Hong Seo, Ae-Ree Kim
Background: Insulin receptor substrate 1 (IRS-1) has been known to be an associated factor with breast cancer progression. However, there has been little study with respect to the relationship between the expression of IRS-1 and breast cancer prognosis in clinical practice. In this study, we evaluated the impact of the estrogen receptor (ER) and IRS-1 on the recurrence and survival of breast cancer patients. Methods: We analyzed the pathologic finding of 376 tissue samples from breast cancer patients who received proper treatment between January 1990 and December 2006 using the tissue microarray...
June 2018: Journal of Cancer Research and Therapeutics
Dapeng Qiu, Feng Han, Hao Zhuang
Aims: Several studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of hepatocellular carcinoma (HCC). However, other studies did not confirm the result. To derive a more comprehensive estimation of the association between miR-499 rs3746444 polymorphism and HCC risk, we conducted a meta-analysis. Materials and Methods: PUBMED, COCHRANE, and WEB OF SCIENCE databases were retrieved for the association studies focused on the relationship between miR-499 rs3746444 polymorphism and the risk of HCC...
June 2018: Journal of Cancer Research and Therapeutics
Yang Li, Yihong Cai, He Chen, Leijin Mao
Objective: To quantitatively investigate the effect of GSTP1 hypermethylation on hepatocellular carcinoma (HCC) using a meta-analysis of available case-control studies. Materials and Methods: Previous studies have primarily evaluated the incidence of GSTP1 hypermethylation in HCC and corresponding control groups, and compared the incidence of GSTP1 hypermethylation in tumor tissues, pericancer liver tissues, normal liver issues, and nontumor liver tissues with that in other diseases...
June 2018: Journal of Cancer Research and Therapeutics
Shao-Li Zhao, Zhao-Hui Mo, Hong-Hui He, Li-Ling Zhao, Yan-Hong Xie
Purpose: The balance between T helper (Th) cells Th1- and Th2-related cytokines plays a key role in the clinical process of acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). The objective of this study was to assess the status of Th1/Th2 cytokines in patients with ACS and T2D or IGT. Methods: A total of 201 ACS patients were enrolled in the study. All ACS patients were divided into three groups: Group I-patients with normal glucose tolerance (NGT), Group II-patients with IGT and Group III-patients with T2D...
June 2018: Journal of Cancer Research and Therapeutics
Yuqing Shen, Ying Yin, Yaqin Peng, Dan Lv, Fengqin Miao, Fei Dou, Jianqiong Zhang
Objective: Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide. The discovery of new therapies against HCC is highly dependable on finding molecules which play essential roles in cancer development. The objective of this study was to evaluate the activity of gamma secretase (γ-secretase), and the antitumor effects of a γ-secretase inhibitor (GSI) in HCC. Methods: The expression of presenilin 1 (PS1), a core component of γ-secretase, was examined by Western blot...
June 2018: Journal of Cancer Research and Therapeutics
Rui Gu, Yifu Sun
Objective: Osteosarcoma is the most common malignant bone tumor that occurs in children and adolescents. Various studies have investigated the role of serum alkaline phosphatase (ALP) level in patients with osteosarcoma but report conflicting findings. Thus, a meta-analysis to assess its prognostic value more precisely is conducted. Materials and Methods: Pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) was used to assess the prognostic role of serum ALP level...
June 2018: Journal of Cancer Research and Therapeutics
Ying Liang, Wen Han, Hongwei Yan, Qiqi Mao
Aim of Study: The CYP3A5*3 allele (A6986G transition in intron 3) is the major member of cytochrome P450 subfamily, which plays a pivotal role in exogenous carcinogens of liver. Variation of the CYP3A5*3 (rs776746 A > G) can lead to oxidation and inactivation of testosterone, which may result in individual susceptibility to prostate cancer. Methods: All eligible published studies about association between CYP3A5*3 polymorphisms and prostate cancer risk were searched in PubMed, Embase, Web of Science, and Cochrane Library, for the period up to August 2015...
June 2018: Journal of Cancer Research and Therapeutics
Yongjiang Li, Wenbiao Zhang, Shuangjiang Li, Chongqi Tu
Introduction: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. Materials and Methods: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library...
June 2018: Journal of Cancer Research and Therapeutics
Cigdem Damla Cetinkaya, Mehmet Gurbilek, Mehmet Koc
Context: Radiotherapy is the commonly used therapeutic modality for inoperable cancer types. We investigated chemoradiotherapy (CRT) effects on the Na + /K + -ATPase enzyme. Aims: The aim of the present study was to determine the usefulness of Na + /K + -ATPase enzyme as a prognostic factor and as a potential target for increasing the CRT response of nonsmall cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Settings and Design: We prospectively evaluated 30 patients (all were treated with CRT) and 20 healthy controls...
June 2018: Journal of Cancer Research and Therapeutics
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