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Journal of Cancer Research and Therapeutics

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https://www.readbyqxmd.com/read/30197374/retraction-correlation-of-serum-intercellular-adhesion-molecule-1-and-vascular-endothelial-growth-factor-with-tumor-grading-and-staging-in-breast-cancer-patients
#1
(no author information available yet)
[This corrects the article DOI: 10.4103/0973-1482.204894].
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197373/thalassemia-cholangiocarcinoma-and-vitamin-e-deficiency-a-scenario-in-endemic-area-insoutheast-asia
#2
LETTER
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197372/significance-of-documentation-of-secondhand-smoke-in-history-taking-procedure-of-head-and-neck-squamous-cell-carcinoma-patients-with-no-tobacco-habit
#3
LETTER
Anjali P Ganjre
No abstract text is available yet for this article.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197371/nasopharyngeal-carcinoma-with-unusual-metastasis-to-urinary-bladder
#4
LETTER
Neha Seth, Jatin Sundersham Gandhi, Sunil Pasricha, Anurag Mehta
Nasopharyngeal carcinoma (NPC) metastasizing to urinary bladder is an uncommon site. We report an interesting case of NPC, on follow-up, presenting with unusual urinary symptoms and mimicking a primary bladder cancer. Subsequent bladder cold cup biopsy and immunohistochemistry unfolded a metastasis of NPC, highlighting unexpected and a rare presentation.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197370/live-birth-following-in-vitro-fertilization-in-a-breast-cancer-survivor-a-case-report-and-review-of-literature
#5
LETTER
V Arun Muthuvel, Manipriya Ravindran, V Aravind Chander, Chandralekha Veluswamy Gounder
The well-being of young cancer survivors is hampered due to the toxic effects of chemotherapy on the ovaries, resulting in infertility. We report a case of a 42-year-old woman with a history of bilateral ductal carcinoma of the breast who underwent radical mastectomy with chemotherapy and radiotherapy was anxious to conceive. In vitro fertilization was performed with donor oocyte; the patient became pregnant and delivered a full term baby with no congenital anomalies. As very few have a background for providing guidance and treatment in this setting, this report highlights the possibility of improving the quality of reproductive life of young survivors by various assisted reproductive techniques, the importance of fertility preservation and a multidisciplinary team approach...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197369/superinfection-of-mature-ovarian-cystic-teratoma-in-a-child-an-unusual-presentation
#6
LETTER
Ashish Chhabra, Shipra Galhotra, Sarita Nibhoria
Mature cystic teratoma is the most common type of ovarian germ cell tumor. The presentation ranges from its asymptomatic nature to various complications such as torsion, rupture, and malignant change. The present case summarizes the rarest complication in the form of superinfection in a young girl without preexisting risk factors.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197368/recurrent-petrositis-due-to-nasopharyngeal-carcinoma-in-an-adult-patient-gradenigo-s-syndrome
#7
LETTER
Asude Aksoy, Asuman Orhan Varoglu
The early diagnosis of very rare nasopharyngeal carcinoma (NPC) is so difficult, to surrounded by structures such as the orbital skull base. With the invasion of the disease, the symptoms are manifested in different ways so that it may be confusion and delay in diagnosis and treatment in this situation. Including otological symptoms (serous otitis media), Gradenigo's syndrome is a rare clinical condition. The majority of published cases involve children, and the most common etiology is otitis media. We report a case of a diabetic man who presented with repeating Gradenigo's syndrome symptoms due to NPC...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197367/durable-complete-response-with-a-short-course-of-streptozotocin-plus-doxorubicin-combination-in-malignant-metastatic-insulinoma
#8
LETTER
Fatih Karatas, Suleyman Sahin, Aydin Aytekin, Muhammet Bekir Hacioglu, Goksen Inanc Imamoglu, Mustafa Altinbas
Due to the cytotoxic effects of old chemotherapy regimens used in the islet cell tumors, capecitabine plus temozolomide combination has now become the first choice in the treatment of malignant insulinoma (MIoma). We present this case to emphasize and remind that a durable complete response in advanced stage MIoma may be achieved with a short course of streptozotocin plus doxorubicin combination.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197366/malignant-peripheral-nerve-sheath-tumor-of-the-thorax-unusual-location-of-a-rare-tumor
#9
LETTER
S Shanmugasundaram, Ashwani Kumar Sachdeva, Prasanth Penumadu, B Srinivas
Malignant peripheral nerve sheath tumor (MPNST) is a rare variety as sporadic tumor but more common when associated with neurofibromatosis, and its usual site of origin lies in the extremities. MPNST of thoracic cavity is a rare site of origin with only anecdotal reports in literature. Progression to a large size without distant metastases is even rarer owing to its high metastatic potential. We present a case of thoracic MPNST highlighting its rarity and the treatment options available to provide a best possible outcome...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197365/poorly-differentiated-carcinoma-of-thyroid-case-report-of-an-uncommon-entity
#10
LETTER
Shaan Khetrapal, Safia Rana, Sujata Jetley, Zeeba Jairajpuri
Malignant thyroid tumors of follicular origin comprise a spectrum, with the indolent well-differentiated thyroid carcinoma (WDTC) at one end and lethal anaplastic thyroid carcinoma (ATC) at the other. Poorly differentiated thyroid carcinoma (PDTC) lies intermediately between WDTC and ATC in terms of morphology and prognostic standpoint. This thyroglobulin producing neoplasm accounts for 4-7% of all thyroid malignancies. PDTC has been controversial due to lack of defined diagnostic criteria. We hereby report a case of PDTC in a 42-year-old female presenting with neck swelling, pain, and dysphagia for 10 months...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197364/malignant-phyllodes-tumor-metastatic-to-bilateral-ovaries-a-krukenberg-like-presentation
#11
LETTER
Garima Durga, Jatin S Gandhi, Anurag Mehta
Phyllodes tumor (PT) is an extremely rare tumor of the breast of mixed mesenchymal and epithelial origin. It may pursue a benign or malignant evolution with distant metastases in the latter case in 3-12% of patients. The most common sites of metastases are the lungs and bones. Although theoretically any organ may have metastasis, it is extremely rare that a PT will metastasize to the bilateral ovaries and present as Krukenberg tumor. Herein, we report such a case.
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197363/lobular-breast-cancer-metastasis-to-uterus-during-adjuvant-tamoxifen-treatment-a-case-report-and-review-of-the-literature
#12
LETTER
Aydin Aytekin, Irem Bilgetekin, Aydin Ciltas, Betul Ogut, Ugur Coskun, Mustafa Benekli
Tamoxifen plays a critical role in the treatment of hormone receptor-positive breast cancer. Despite these great benefits against breast cancer, tamoxifen increases the risk of endometrial pathologies such as endometrial hyperplasia, polyp, and neoplasms because of agonistic effect on endometrial tissues. Therefore, gynecologic follow-up should be carried out during tamoxifen treatment. Uterine tumors are frequently detected as the result of presentation with abnormal uterine bleeding. In addition, genital tract's metastases from distant primary tumors can present with abnormal uterine bleeding...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197362/atypical-presentation-of-hairy-cell-leukemia-significance-of-cd200-on-flow-cytometry
#13
LETTER
Khaliqur Rahman, Surabhi Kumari, Manish Kumar Singh, Ruchi Gupta, Geeta Yadav, Neeraj Kumari, Soniya Nityan
Hairy cell leukemia (HCL) is a rare, low-grade mature B-cell neoplasm with a characteristic clinical, morphological, immunophenotypic, and more recently described molecular (BRAF p.V600E mutation) profile. It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen. Atypical presentations such as absence of splenomegaly and presence of lymphadenopathy and leukocytosis, a hypoplastic marrow masquerading as aplastic anemia, pose a diagnostic challenge to both clinician and pathologist...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197361/design-of-a-slab-phantom-for-breast-dosimetry-applications
#14
Mahdieh Afkhami Ardekani, Mohamad Haghparast, Somaieh Nourollahi, Soheila Refahi
Background: Design of phantoms for use in radiotherapy should consider the complex geometry of breast tissue and inhomogeneity. The aim of this study is design of a slab phantom for breast dosimetry applications. Materials and Methods: In this study, an anatomical slab phantom was designed with cork lung inhomogeneity and plexi colored heart part, also describes the different size of breast and chest wall phantom that have been designed and constructed for dosimetry...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197360/signal-transducer-and-activator-of-transcription-3-downregulation-in-j774a-1-cell-line-as-a-model-of-m2-macrophages-in-tumor-microenvironment
#15
Zahra Seyedi, Mohammad Reza Hashemzadeh, Abasalt Hosseinzadeh Colagar, Mahmoud Reza Jaafari
Aim: Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transducer and activator of transcription 3 (STAT3) in TAM lead to tumor-induced immunosuppression. STAT3 is usually constitutively activated in a variety of malignancies. Consequently, STAT3 has emerged as a promising target for cancer immunotherapy...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197359/concurrent-chemoradiotherapy-with-or-without-induction-chemotherapy-for-the-management-of-cervical-lymph-node-metastasis-from-unknown-primary-tumor
#16
Mohsin Khan, Shahid A Siddiqui
Background: To determine the impact of concurrent chemoradiotherapy (CCRT) with or without induction chemotherapy over radiation alone for the treatment of patients of cervical lymph node metastasis from an unknown primary tumor. Materials and Methods: A total of 96 patients with squamous cell histology of cervical lymph node metastases from unknown primary tumor were retrospectively reviewed. About 12 patients were treated with radiation alone (RT alone), 45 with CCRT, and 39 with induction chemotherapy followed by CCRT (ICCRT)...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197358/efficacy-and-safety-of-everolimus-in-hormone-receptor-positive-breast-cancer-in-a-developing-country-real-life-single-institutional-experience
#17
Tarek Assi, Joseph Kattan, Elie El Rassy, Samer Tabchi, Ralph Chebib, Tania Moussa, Colette Hanna, Fadi El Karak, Fadi Farhat, Marwan Ghosn
Introduction: Breast cancer is the second leading cause of cancer-related mortality despite the staggering improvement in cancer therapeutics. So far, published data illustrate endocrine therapy as the cornerstone treatment for patients with hormone receptor-positive metastatic breast cancer. Unfortunately, most patients eventually develop resistance to this treatment. Methods: The purpose of this study is to evaluate the efficacy of mammalian target of rapamycin inhibition in reversing hormone resistance in the Lebanese breast cancer patients...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197357/combination-therapy-with-azacitidine-etoposide-and-cytarabine-in-the-treatment-of-elderly-acute-myeloid-leukemia-patients-a-single-center-experience
#18
Birgul Onec, Harika Okutan, Murat Albayrak, Esra Saribacak Can, Vedat Aslan, Basak Unver Koluman, Ozge Soyer Kosemehmetoglu, Aynur Albayrak
Aims: The prognosis of acute myeloid leukemia (AML) in elderly patients is worse due to age and comorbidities. Lately, monotherapy with hypomethylating agents like azacitidine (Aza) has been used to prolong overall survival (OS) in AML patients. Herein, we present a retrospective study investigating treatment responses and OS of Aza in combination with etoposide (Eto) and cytarabine (ARA-C) in elderly. Materials and Methods: In this study, therapies and outcomes of 37 newly diagnosed AML patients, >60 years old, and ineligible for intensive chemotherapy were investigated retrospectively...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197356/auditory-function-and-quality-of-life-in-patients-receiving-cisplatin-chemotherapy-in-head-and-neck-cancer-a-case-series-follow-up-study
#19
Balamurali Kalyanam, N Sarala, S M Azeem Mohiyuddin, Ravi Diwakar
Background: Cisplatin is one of the anticancer drugs used for head and neck cancers. Although some studies have shown that cisplatin can cause ototoxicity, periodic audiometric assessments have not been extensively studied in the Indian rural population. Hence, this study has been undertaken to evaluate the effects of cisplatin on hearing. Materials and Methods: Fifty-nine patients with squamous cell carcinomas of head and neck, who received cisplatin chemotherapy, were recruited...
July 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30197355/the-factors-that-affect-the-prediction-of-lymph-node-metastasis-in-prostate-cancer
#20
Hakan Turk, Sıtkı Ün, Osman Koca, Ahmet Cinkaya, Hilmi Kodaz, Ferruh Zorlu
Objective: We aimed to demonstrate the effects of clinical evaluations as well as biopsy characteristics in terms of lymph node involvement (LNI) despite the small number of patients in our study. Materials and Methods: A total of 221 patients who underwent radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND) in our clinic between 2010 and 2015 and who met the inclusion criteria were enrolled in our study group. All of the patients were evaluated in terms of age, prostate-specific antigen (PSA) value before transrectal ultrasound-guided prostate biopsy (TRUSPB), digital rectal examination, Gleason score (GS) on TRUSPB, percentage of positive cores on TRUSPB, total number of positive cores, highest percentage of cancer in positive cores, and number of lymph nodes removed at RP...
July 2018: Journal of Cancer Research and Therapeutics
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