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Journal of Cancer Research and Therapeutics

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https://www.readbyqxmd.com/read/30249916/tian-xian-liquid-is-it-a-really-effective-anticancer-dietary-supplement
#1
LETTER
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249915/contraception-opisthorchiasis-and-cholangiocarcinoma
#2
LETTER
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249914/sunitinib-induced-acute-severe-hypothyroidism-in-a-case-of-metastatic-gastrointestinal-stromal-tumor-a-case-report
#3
LETTER
Kazi Sazzad Manir, Debanti Banerjee, Rahul Bhowmick, Chhaya Roy
Thyroid abnormalities are found nearly 70% cases receiving sunitinib therapy. Mostly, patients suffer transient hypothyroidism rarely presents with overt acute symptoms requiring levothyroxine replacement. Onset is variable in published literature. We report a case of metastatic gastrointestinal stromal tumor receiving sunitinib with normal baseline thyroid function. The patient developed symptoms of acute severe hypothyroidism with high thyroid stimulating hormone level on the 4th week of therapy. The patient responded with oral levothyroxine...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249913/malignant-melanoma-metastasizing-to-tonsil-a-rare-presentation
#4
LETTER
Geethu Babu, M Biju Azariah, P Sindhu Nair, Francis V James
Malignant melanoma (MM) has a high potential of lymphatic and hematogeneous spread, and metastatic disease is always incurable with a high mortality. We present a rare phenomenon of MM metastasizing to the palatine tonsil.
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249912/sinonasal-paraganglioma-and-cushing-s-syndrome-a-rare-association
#5
LETTER
Puneeth Kumar, Amit Kumar Dey, Kartik Mittal, Rajaram Sharma, Padma Badhe, Sunita Kale
In general, paragangliomas are symptomatic tumors, which may be clinically taken for other tumors, benign or malignant lesions. Paragangliomas of the nasal cavity and paranasal sinuses are an extremely rare entity and what is even rarer is its association with ectopic adrenocorticotropic hormone production. We report this very rare case to highlight the rare association of Cushing's syndrome with nasal paraganglioma and the importance of total surgical resection in its treatment.
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249911/hemangioma-of-rib-masquerading-a-malignancy
#6
LETTER
Shailja Puri, Neelam Gupta, Sarita Asotra
Hemangioma of bone is a rare bone tumor accounting for <1% of all osseous tumors. Hemangiomas are common in skull and vertebrae but uncommon in rib. Rib hemangiomas may increase in size over a period and may cause symptoms due to increasing size. Preoperative diagnosis is not always possible due to overlapping radiological features between benign and malignant lesions. Use of preoperative aspiration and biopsy has their own risks and benefit. Excision of rib in case of monostotic rib lesions is the treatment of choice due to low risk of recurrence and no reported postoperative complications...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249910/renin-producing-germ-cell-tumor-in-the-pineal-apparatus-and-mediastinum-a-rare-case-report
#7
LETTER
Manabu Uematsu, Hiroshi Yokouchi, Yoshinori Tanino, Mitsuru Munakata
Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found to have hypertension at a regular visit postoperatively. Laboratory findings revealed high plasma levels of renin activity and that of aldosterone concentration. Chest computed tomography demonstrated a large tumor in the mediastinum...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249909/successful-management-of-a-patient-with-radiological-presentation-of-choriocarcinoma-syndrome-before-induction-chemotherapy
#8
LETTER
Takashi Yoshida, Yutaro Hayami, Kenji Yoshida, Hidefumi Kinoshita, Tadashi Matsuda
Choriocarcinoma syndrome is a life-threatening lysis syndrome caused by blood vessel rupture and subsequent tumor bleeding. We describe a case of pretreatment choriocarcinoma syndrome that developed in a 27-year-old man. He underwent a high orchiectomy at a local hospital and was diagnosed with metastatic testicular tumor given the high serum human chorionic gonadotropin levels (943,601 mIU/mL). Thus, he was referred to our institution. Although he had bulky lung metastases and alveolar bleeding, we were able to administer full-dose chemotherapy with etoposide and cisplatin...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249908/trisomy-3-as-an-acquired-cytogenetic-abnormality-in-primary-acute-megakaryoblastic-leukemia
#9
LETTER
Vahid Fallah Azad, Azim Mehrvar, Narjes Mehrvar
Acute myeloid leukemia has a rare subtype in French-American-British classification as M7 or acute megakaryoblastic leukemia. Chromosome abnormalities in cases with acute megakaryoblastic leukemia can affect their prognosis. Evaluation of these abnormalities and their impact are not fully elucidated. This case presentation is about 16 months female who has a rare abnormality (trisomy 3) alongside acute megakaryoblastic leukemia. The remarkable point is that her malignancy is as primary or non-Down syndrome acute megakaryoblastic leukemia...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249907/low-grade-myofibroblastic-sarcoma-of-the-pancreas-a-case-report-and-literature-review
#10
LETTER
Long Peng, Yi Tu, Yong Li, Weidong Xiao
Low-grade myofibroblastic sarcoma (LGMS) is a malignant tumor with myofibroblastic differentiation, which frequently occurs in the oral cavity and extremities. Here, we report a case of LGMS of the pancreas in a 44-year-old female presented to our hospital with recurrent upper abdominal pain. Computed tomography revealed a low-density solid tumor at the body of the pancreas. Distal pancreatectomy combined with splenectomy was performed. LGMS of the pancreas was diagnosed by the histological features together with immunohistochemical findings...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249906/pancreatic-primitive-neuroectodermal-tumor-focus-on-radiological-features-and-differential-diagnosis-a-case-report-and-literature-review
#11
LETTER
Wenguang Liu, Desheng Xiao, Xiaoping Yi, Wenzheng Li
Primitive neuroectodermal tumor (PNET) is an exceedingly rare type of malignant tumor. The diagnosis of pancreatic PNET is usually challenging for radiologists and surgeons, especially when an accurate preoperative diagnosis is needed. Herein, we report a case of a 36-year-old patient with a mass diagnosed as PNET in the head of the pancreas and present a literature review. Compared to previous literature reports, there were some imaging features observed by computed tomography (CT) in our case that might be helpful for a relatively accurate preoperative diagnosis...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249905/bevacizumab-and-stereotactic-radiosurgery-achieved-complete-response-for-pediatric-recurrent-medulloblastoma
#12
LETTER
Ming Zhao, Xiaopeng Wang, Xiangping Fu, Zhiwen Zhang
Recurrent medulloblastoma has a very poor prognosis in children regardless of the treatment employed. We report the case of a 3-year-old child with recurrent refractory medulloblastoma who was treated with both bevacizumab and stereotactic radiosurgery (SRS). The boy was found to harbor a tumor in the cerebral posterior fossa in November 2010. Craniotomy was performed to remove the tumor completely. Postoperative pathological examination showed desmoplastic medulloblastoma. Craniospinal radiotherapy and chemotherapy were performed...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249904/primary-large-cell-neuroendocrine-carcinoma-of-the-prostate-in-a-hormone-naive-patient-a-case-report-from-taiwan
#13
LETTER
Kai-Yi Tzou, Wei-Hung Cheng, Wei-Hwa Lee, Chen-Hsun Ho
Large cell neuroendocrine carcinoma (LCNEC) of the prostate is extremely rare. Previously reported cases in the literature were almost exclusively developed in men receiving androgen deprivation therapy for prostate adenocarcinoma. We herein present a case of de novo LCNEC: A 66-year-old male was incidentally diagnosed as LCNEC after he underwent transurethral resection of prostate. The stage was T4N1M1. Therefore, the patient was treated with 6 cycles of cisplatin and etoposide in the following 6 months, which achieved a partial remission...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249903/preventive-effect-of-ethanolic-extract-of-cactus-opuntia-ficus-indica-cladodes-on-methotrexate-induced-oxidative-damage-of-the-small-intestine-in-wistar-rats
#14
Amira Akacha, Tarek Rebai, Lazhar Zourgui, Mohamed Amri
Context: Methotrexate (MTX) is a cytotoxic chemotherapeutic element for various inflammatory diseases. The cytotoxic effect of MTX is also seen in normal tissues having a high proliferation rate including gastrointestinal and bone marrow. Aims: The aim of this study was to find out whether oxidative damage could be relevant for MTX-induced toxicity in vivo using Wistar rats and to investigate the preventive potential of cactus cladodes. Materials and Methods: Adult and healthy male Wistar rats (200-250 g) were pretreated by ethanol fraction of cactus cladodes...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249902/hepatitis-b-and-c-rates-are-significantly-increased-in-certain-solid-tumors-a-large-retrospective-study
#15
Hakan Kocoglu, Mustafa Karaca, Deniz Tural, Erhan Hocaoglu, Yildiz Okuturlar, Zeynep Fetullahoglu, Meral Gunaldi, Rumeysa Ciftci, Savas Tuna, Orhan Kemal Yuce, Gulsum Ozet, Ahmet Ozet, Mustafa Benekli
Objective: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are associated with significant morbidity and mortality among cancer patients who received cytotoxic chemotherapy. The aim of current study was to elucidate the prevalence of HBV and HCV among large population of solid cancers and lymphoma and to compare them with large number of control group. Patients and Methods: Between 2000 and 2014, 8322 cancer patients who were admitted to Oncology Departments were evaluated retrospectively and 3890 patients in whom hepatitis serology were available were included in this study...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249901/four-and-a-half-lim-protein-1-promotes-paclitaxel-resistance-in-hepatic-carcinoma-cells-through-the-regulation-of-caspase-3-activation
#16
Lei Zhou, Lihua Ding, Jie Liu, Yanan Zhang, Xiaoli Luo, Lichun Zhao, Jun Ren
Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Aim: To investigate the mechanisms of paclitaxel resistance in hepatocellular carcinoma cells and find promising molecular target for HCC therapy. Materials and Methods: To investigate the effects of FHL1 on chemo resistance in HCC cells, we generated FHL1 knock-down stable cell lines with HepG2 and SMMC7721 cells. Cell viability assay, colony formation and xenograft experiments assay were performed to detect effect of FHL1 on Paclitaxel or Oxaliplatin resistance in vitro and in vivo...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249900/a-randomized-phase-iii-study-of-hepatic-arterial-infusion-chemotherapy-with-5-fluorouracil-and-subsequent-systemic-chemotherapy-versus-systemic-chemotherapy-alone-for-colorectal-cancer-patients-with-curatively-resected-liver-metastases-japanese-foundation-for
#17
RANDOMIZED CONTROLLED TRIAL
Mitsuo Kusano, Toru Aoyama, Koji Okabayashi, Koichi Hirata, Yasushige Tsuji, Shoji Nakamori, Toshimasa Asahara, Yasuo Ohashi, Takaki Yoshikawa, Junichi Sakamoto, Koji Oba, Shigetoyo Saji
Aim: This randomized phase III trial compared hepatic arterial infusion (HAI) chemotherapy with 5-fluorouracil (5-FU) followed by uracil/tegafur (UFT) and leucovorin (LV) versus UFT/LV alone for patients with curatively resected liver metastases from colorectal cancer (CRC). Methods: The study was designed to include 280 patients to be randomized to receive either HAI with 5-FU followed by UFT/LV (Arm A) or UFT/LV alone (Arm B) to assess whether HAI chemotherapy improved disease-free survival (DFS)...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249899/clinical-significance-of-interleukin-6-in-diagnosis-of-lung-oral-esophageal-and-gall-bladder-carcinomas
#18
Anjali Vinocha, Rajesh K Grover, Rani Deepak
Introduction: Chronic inflammation predisposes to cancer. Cytokines play an essential role in cancer pathogenesis. Interleukin-6 (IL-6) is a pleiotropic cytokine that enables growth and differentiation of tumors. The effects of IL-6 are mediated by signal transducers and activators of transcription 3 (STAT3). STAT3 deficiency reduced tumor incidence and growth while STAT3 hyperactivation has an opposite effect; also it negatively regulates p53 gene. IL-6/STAT3 signaling is crucial in carcinogenesis linked to inflammation...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249898/human-colorectal-cancer-antigen-ga733-2-fc-fused-to-endoplasmic-reticulum-retention-motif-kdel-enhances-its-immunotherapeutic-effects
#19
Yuan-Yuan Fu, Jin Zhao, Jong-Hwa Park, Geun-Won Choi, Kong Young Park, Youn Hyung Lee, In Sik Chung
Objective: The aim of this is to compare the immunotherapeutic effects of human colorectal cancer antigen GA733-2 fused to the Fc fragment of antibody (GA733-2-Fc) and to Fc and endoplasmic reticulum (ER) retention motif KDEL (GA733-2-Fc-KDEL). Materials and Methods: Recombinant GA733-2-Fc and GA733-2-Fc-KDEL were produced from infiltrated Nicotiana benthamiana leaves and purified by affinity chromatography. Glycan structures were determined by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30249897/advanced-signet-ring-cell-carcinoma-of-the-stomach-clinicopathological-characteristics-of-patients-and-efficacy-of-the-modified-docetaxel-cisplatin-and-fluorouracil-regimen
#20
Yakup Bozkaya, Gökmen Umut Erdem, Nuriye Yildirim Özdemir, Cemil Hocazade, Ozan Yazici, Nebi Serkan Demirci, Nurullah Zengin
Background: The aim of this retrospective study was to investigate the clinicopathological characteristics of patients with signet-ring cell carcinoma (SRCC) of the stomach, and the efficacy of the modified docetaxel, cisplatin, and fluorouracil (mDCF) chemotherapy regimen. Patients and Methods: Sixty-five patients diagnosed with metastatic or recurrent SRCC and treated with at least one course of mDCF regimen as the first-line treatment at our hospital July 2007 and January 2015, were included in this study...
September 2018: Journal of Cancer Research and Therapeutics
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