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Journal of Cancer Research and Therapeutics

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https://www.readbyqxmd.com/read/27721269/prolonged-overall-survival-of-patients-with-leptomeningeal-carcinomatosis-from-nonsmall-cell-lung-cancer
#1
Yanfang Ju, Shengjie Sun, Jinliang Wang, Shunchang Jiao
Leptomeningeal metastasis (LM) carries a devastating prognosis. Treatment selection is limited for patients with LM. We introduced to use nimotuzumab (also known as h-R3) for treating LM of nonsmall cell lung cancer. Here, we report two patients in our treatment who had prolonged overall survival over 1 year each. The pressure of cerebrospinal fluid of the patients decreased remarkably after intrathecal therapy. Symptoms of the patients had been improved quickly after one or two times of intrathecal therapy...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721268/distribution-and-prognosis-of-mediastinal-lymph-node-metastases-of-nonsmall-cell-lung-cancer
#2
Dawei Guo, Yiming Ni, Xiayi Lv, Zhihao Zhang, Peng Ye
BACKGROUND AND OBJECTIVE: With the popularity of minimally invasive techniques, preoperatively determining whether mediastinal lymph node dissection (MLD) is necessary for patients with cN1/2 nonsmall cell lung cancer (NSCLC) has sparked controversy once again. This study aims to analyze whether different primary sites are associated with the distribution of mediastinal lymph node metastases and to investigate the necessity of lymph node dissection and the factors influencing prognosis...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721267/outcomes-of-surgical-treatments-of-pulmonary-hamartoma
#3
Tao Wang, Yang Liu
OBJECTIVE: To retrospectively analyze the results of surgical resection in patients with pulmonary hamartoma (PH) in the Peoples Liberation Army (PLA) General Hospital during the past 30 years. MATERIALS AND METHODS: We retrospectively enrolled 226 patients with PH who underwent surgical resection in the PLA General Hospital between January 1980 and January 2010, including tumors of pulmonary parenchyma (n = 216) and endobronchial tumors (n = 10). The type of operation include tumor enucleation (n = 103), wedge resection (n = 103), and lobectomy (n = 20)...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721266/a-comparison-of-drug-resistances-of-targeted-drugs-for-advanced-renal-cell-cancer-approved-by-the-food-and-drug-administration-a-meta-analysis-of-randomized-clinical-trials
#4
Ming Guo, Yunsong Cao, Jingzhe Yang, Jingfeng Zhang
PURPOSE: The purpose of this study was to conduct network meta-analysis to assess drug resistances of the Food and Drug Administration-approved drugs for advanced renal cell carcinoma. MATERIALS AND METHODS: Database searches were conducted to identify randomized controlled trials reporting results for eligible treatments. After searching for PubMed, MEDLINE, EMBASE, and ISI Web of Science, 22 studies (n = 7854 patients) were included for the comparison of drug resistance in the present meta-analysis...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721265/meta-analysis-of-gemcitabine-and-cisplatin-combination-chemotherapy-versus-gemcitabine-alone-for-pancreatic-cancer
#5
Diyu Huang, Jie Fang, Gaojian Luo
PURPOSE: The aim of this study is to assess the efficacy and safety of combination chemotherapy with gemcitabine (GEM) and cisplatin (CIS) compared with GEM alone in patients with pancreatic cancer. METHODS: A computerized search through electronic databases, including PubMed (until February 2016), was performed to obtain eligible randomized controlled trials that compared effectiveness of GEM and CIS combination chemotherapy with GEM alone in patients with pancreatic cancer...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721264/meta-analysis-of-therapeutic-effects-and-the-risks-of-hypertension-and-hyperglycemia-in-patients-with-renal-cell-carcinoma-who-were-receiving-antiangiogenic-drugs
#6
Lingling Chang, Ying An, Shuling Yang, Xiaosu Zhang
PURPOSE: A meta-analysis of published data was conducted to investigate the therapeutic effects in patients with renal cell carcinoma (RCC) who were receiving antiangiogenic drugs. METHODS: A computerized search through electronic databases, including PubMed (until February 2016), was performed to obtain eligible randomized controlled trials that compared the effectiveness of antiangiogenic with control groups (everolimus, placebo, and interferon [IFN] alfa) in patients with RCC...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721263/combined-nimotuzumab-with-chemoradiotherapy-in-patients-with-locally-advanced-or-metastatic-esophageal-squamous-cell-carcinoma-a-retrospective-study
#7
Xiaojing Lai, Qing Gu, Xiao Zheng, Guan Liu, Wei Feng, Xiao Lin, Weimin Mao
AIMS: To observe the efficacy and toxicities of combined nimotuzumab with chemoradiotherapy as the first-line treatment to advanced esophageal squamous cell carcinoma (ESCC). METHODS: The clinical data of 43 patients with local advanced or metastatic ESCC treated with nimotuzumab combined with chemoradiotherapy in our hospital were included in this retrospective study. The overall response, adverse events, overall survival (OS), and progressive-free survival (PFS) were analyzed...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721262/the-efficacy-and-safety-of-simultaneous-integrated-boost-intensity-modulated-radiation-therapy-for-esophageal-squamous-cell-carcinoma-in-chinese-population-a-single-institution-experience
#8
Yujin Xu, Zhun Wang, Guan Liu, Xiao Zheng, Yuezhen Wang, Wei Feng, Xiaojing Lai, Xia Zhou, Pu Li, Honglian Ma, Jin Wang, Xiao Hu, Ming Chen
PURPOSE: To evaluate the clinical efficacy and toxicity of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in patients with esophageal squamous cell carcinoma (ESCC) in Chinese population. PATIENTS AND METHODS: Patients with ESCC, who received SIB-IMRT from September 2011 to January 2013 were retrospectively analyzed. The SIB-IMRT plans were designed to deliver primary gross tumor volume at 60-64.4 Gy in 28-30 fractions, and planning target volume at 50...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721261/a-meta-analysis-of-contrast-enhanced-computer-tomography-in-the-diagnosis-of-colorectal-cancer
#9
Shuqian Man, Jianxun Zou, Mingjie Wang, Feng Liang, Shuyan Chen, Xueyong Zhang, Xudan Li
OBJECTIVE: To investigate the diagnostic value of contrast-enhanced computer tomography in diagnosis of colorectal cancer. METHODS: All the diagnostic studies about contrast-enhanced computer tomography in diagnosis of colorectal cancer were searched in the PubMed, Medline, EMBASE, CNKI, and Wanfang databases and included in this meta-analysis. The diagnostic sensitivity and specificity were pooled. The data were analyzed by statistic software Meta-DiSc1.4. RESULTS: After searching the databases, eight studies with 4764 cases were finally included in this meta-analysis...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721260/does-hospital-based-transitional-care-reduce-the-postoperative-complication-in-patients-with-enterostomy-a-meta-analysis
#10
Yi Chen, Jinyan Jiang, Yuehong Wu, Jingjing Yan, Huali Chen, Xuemei Zhu
OBJECTIVE: The objective of the study is to investigate whether hospital-based transitional care can reduce the postoperative complication in patients who received enterostomy or not by pooling the published prospective clinical studies. MATERIALS AND METHODS: Prospective clinical studies related to hospital-based transitional care for reducing the postoperative complication in patients with enterostomy were searched in the electronic databases of PubMed, Medline, EMBASE, CNKI, and Wanfang...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721259/expression-of-excision-repair-cross-complementation-group-1-in-locoregionally-advanced-nasopharyngeal-carcinoma-treated-with-cisplatin-based-induction-chemotherapy
#11
Chuan Shen, Lingling Chen, Jiangtao Fu, Hongbin Lin
OBJECTIVE: The purpose of this study was to evaluate the expression of excision repair cross-complementation group 1 (ERCC1) in locoregionally advanced nasopharyngeal carcinoma (NPC) treated with cisplatin-based induction chemotherapy. METHODS: Eighty-five patients with locoregionally advanced NPC treated with cisplatin-based induction chemotherapy were included in this study. The expression level of ERCC1 protein in cancer tissues was detected by immunohistochemistry, and the expression level was divided into the high- and low-expression groups according to their expression level...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721258/inhibitory-roles-of-mir-320-in-osteosarcoma-via-regulating-e2f1
#12
Haojie Wu, Weihua Li, Minghui Zhang, Shutao Zhu, Dengfeng Zhang, Xiao Wang
OBJECTIVES: Osteosarcoma (OsC) is the most common primary bone malignant tumor with lower incidence and high degree of malignancy, but the exact mechanism remains unknown. More evidence demonstrated microRNAs (miRNAs) could contribute to tumor progression. In this study, we investigated the expression and functions of miR-320 in OsC cells. MATERIALS AND METHODS: miR-320 expression levels in several human OsC cell lines and human normal osteoblastic cell line were tested by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR)...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721257/a-meta-analysis-of-association-between-glutathione-s-transferase-gene-polymorphism-and-osteosarcoma-chemosensitivity-in-chinese-population
#13
Jun Lan, Qi Yang, Mingping Zhou, Rongcheng Xu, Chongbin Zhou, Jiwei Wang, Haiya Zheng
OBJECTIVE: In this study, a meta-analysis was performed to investigate whether there is an association between glutathione S-transferase (GST) gene polymorphism and chemosensitivity in patients with osteosarcoma. METHODS: A comprehensive electronic database search was performed between January 1, 2016, and May 21, 2016. All eligible studies related to GST gene polymorphism and chemosensitivity in patients with osteosarcoma were screened and included in the current meta-analysis...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721256/the-rho-gtpase-rhoe-exerts-tumor-suppressing-effects-in-human-esophageal-squamous-cell-carcinoma-via-negatively-regulating-epidermal-growth-factor-receptor
#14
Haojie Wang, Yi Wang, Bing Liang, Fei He, Yong Li, Jianbo Che, Xiaohui Li, Hui Zhao, Gongning Shi
OBJECTIVES: The objective of this study was to investigate the expression pattern, functions, and possible mechanisms of RhoE/Rnd3, a novel member of the Rho GTPases family, in human esophageal squamous cell carcinoma (ESCC) cells by using molecular and cell-based experiments. MATERIALS AND METHODS: Quantitative polymerase chain reaction and Western blotting were carried out to determine the mRNA and protein expression of RhoE in ESCC cell lines, respectively. Both 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazoliumbromide (MTT) and flow cytometry were applied to evaluate the effects of RhoE overexpression on ESCC cell growth and apoptosis...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721255/application-value-of-sentinel-lymph-node-biopsy-in-the-radical-operation-for-stage-ii-advanced-gastric-cancer
#15
Yongzheng Xie, Fangjun Li, Xuequn Ren
OBJECTIVE: This study aims to explore the application value of sentinel lymph node (SLN) biopsy in patients with Stage II advanced gastric cancer and its effects on prognosis. MATERIALS AND METHODS: A total of 43 patients with Stage II gastric cancer (experimental group) admitted to our department from March 2011 to February 2013 underwent radical operation using SLN biopsy, and 51 patients with gastric cancer D2 (the control group) received conventional radical operation...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721254/s-1-combined-with-cisplatin-chemotherapy-for-advanced-gastric-cancer
#16
Chen Weidong, Xia Lijun
OBJECTIVE: To observe the short-term efficacy and safety of S-1 combined with cisplatin (DDP) chemotherapy for advanced gastric cancer (AGC). MATERIALS AND METHODS: Sixty-six patients were diagnosed with AGC and were admitted to our department from February 2012 to January 2015 and retrospectively analyzed. Of these patients, 31 (experimental group) underwent S-1 combined with DDP chemotherapy and 35 received oxaliplatin combined with tegafur and calcium folinate chemotherapy regimen (control group)...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721253/the-association-between-runt-related-transcription-factor-3-gene-promoter-methylation-and-gastric-cancer-a-meta-analysis
#17
Xu Liu, Lina Wang, Yongtie Guo
OBJECTIVE: To systematically evaluate the relationship of the methylation of the human-runt-related transcription factor 3 (RUNX3) promoter region and gastric cancer risk through meta-analysis. MATERIALS AND METHODS: The studies published in PubMed, EMBASE, Ovid, and CNKI were retrieved. The association between RUNX3 gene promoter methylation and gastric cancer was analyzed using Stata 11.0 (http://www.stata.com; Stata Corporation, College Station, TX, USA) and Review Man 5...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721252/evaluating-the-efficacy-and-safety-of-continuous-arterial-infusion-chemotherapy-with-cisplatin-and-5-fluorouracil-in-treating-oral-cancer
#18
Min Ye, Xudan Li, Weidong Liu, Haibiao Tao, Junjie Yan
OBJECTIVE: To investigate the clinical effects and safety for cisplatin combined with 5-fluorouracil (5-FU) intra-arterial chemotherapy in the treatment of oral cancer. MATERIALS AND METHODS: A total of ninety cases with oral cancer were recruited in this study. Forty-three subjects received the pingyangmycin (PYM) (control group) with PYM 8 mg, intramuscular injection, QD for 21 days per cycle. Moreover, other 47 cases received cisplatin 100 mg/m 2 24 h perfusion chemotherapy, day 1 with 21 days per cycle, and 5-FU 1000 mg/m 2 perfusion chemotherapy 72 h with 21 days per cycle...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721251/application-value-of-endoscopic-submucosal-dissection-and-endoscopic-mucosal-resection-for-treatment-of-rectal-carcinoids
#19
Xiaohuan Li, Yongxian Gui, Wenliang Han, Hongjian Jiang, Daihua Qi, Yi Yang
OBJECTIVE: The objective of this study is to explore the clinical effect and safety of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) for treatment of rectal carcinoids. METHODS: A retrospective analysis was conducted on 42 patients with rectal carcinoids who were hospitalized and subjected to surgical treatment in our hospital from January 2010 to November 2015. The patients were categorized into two groups based on treatment received: ESD (n = 22) and EMR (n = 20)...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27721250/adjuvant-therapy-with-heparin-in-patients-with-lung-cancer-without-indication-for-anticoagulants-a-systematic-review-of-the-literature-with-meta-analysis
#20
Yuman Yu, Qun Lv, Bin Zhang, Fen Lan, Yifan Dai
BACKGROUND: The effect of heparin in improving cancer survival has gained increasing attention over the past decades. Several clinical trials have evaluated the role of heparin on survival outcome and its safety profile in lung cancer patients. Thus, we performed a systematic review and meta-analysis from the results of randomized controlled trials (RCTs) to assess the efficacy and safety of heparin in patients with lung cancer without indication for anticoagulants. METHODS: We searched PubMed, Embase, and The Cochrane Central Register of Controlled Trials databases for relevant studies...
October 2016: Journal of Cancer Research and Therapeutics
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