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Néphrologie & Thérapeutique

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https://www.readbyqxmd.com/read/29325696/urinary-mrna-analysis-of-biomarkers-to-epithelial-mesenchymal-transition-of-renal-allograft
#1
Imen Mezni, Pierre Galichon, Mohammed Mongi Bacha, Yi-Chun Xu-Dubois, Imen Sfar, David Buob, Sabrina Benbouzid, Rim Goucha, Yousr Gorgi, Ezzedine Abderrahim, Mondher Ounissi, Karine Dahan, Nacera Ouali, Alexandre Hertig, Isabelle Brocheriou, Aly Raies, Taieb Ben Abdallah, Éric Rondeau
Renal allograft loss is most often a chronic process, irrespective of the mechanism at stake. In this prospective study, we studied the expression of epithelial to mesenchymal transition (EMT) markers vimentin and β-catenin by immunohistochemistry in the surveillance biopsy and measured the mRNA encoding vimentin (VIM), CD45, GAPDH and uroplakin 1a (UPK) by quantitative PCR in urinary cells in 75 renal transplant patients. The aim is to establish a simple screening test for chronic renal allograft dysfunction...
January 8, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29311011/-screening-for-nephropathy-in-major-sickle-cell-syndromes-in-patients-monitored-at-the-national-reference-center-for-sickle-cell-disease-in-niamey-niger
#2
Moumouni Garba, Zeinabou Maiga Moussa Tondi, Hassan Diongoule, Samaila Aboubacar, Abdou Ide, Nadège Ruddy Biyao-Nelson, Illiassou Soumaila, Soumana Alido
BACKGROUND: Sickle cell anemia is the most common hereditary hemopathy in the world. It is a disease that attacks all the systems of the organism. The kidneys are among the most sensitive organs of this disease. The main objective of this study is to detect sickle cell nephropathy in patients followed at the National Reference Center for Sickle Cell Disease in Niamey. METHODS: It is a prospective study carried out over a period of one year (January to December 2016)...
January 5, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29295767/-micro-inflammation-and-digestive-bacterial-translocation-in-chronic-kidney-disease
#3
Valérie Olivier, Catherine Dunyach-Remy, Jean-Philippe Lavigne, Olivier Moranne
Micro-inflammation has been recognized as a major factor associated with the poor prognosis of patients with chronic kidney disease. Those patients have an increased rate of pro-inflammatory markers like interleukin 6, C-Reactive protein, Tumor Necrosis Factor α and fibrinogen. Among multiple and complex causes of micro-inflammation the gut microbiota could be an important actor considering the dysbiosis in chronic kidney disease which would enhance the synthesis of uremic toxins with cardiovascular toxicity and the bacterial translocation...
December 30, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29295766/-vancomycin-poisoning-successfully-treated-with-intermittent-hemodialysis-a-case-report
#4
Jérémy Zaworski, Marie Frimat, Marion Duval, Camille Saint-Jacques, Élise Bouderlique, François Glowacki, Christian Noël, Marc Hazzan, François Provôt
We report a case of a 43 years old man who was intoxicated by a 25g vancomycin overload. An anuric acute renal failure rapidly occured. The vancomycinemia was measured as high as 360mg/L (normal range: 15-35mg/L). We started an intermittent hemodialysis program to clear out the vancomycin. The vancomycinemia decreased below the treshold of our laboratory after the eighth session. Three supplementary sessions were needed because of a persistant oliguria. The kidney function slowly improved and was back to normal (seric creatinin: 80micromol/L) 3 weeks after the patient had gone home...
December 30, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29291942/-icodextrin-what-arguments-for-and-against-its-use-as-an-osmotic-agent-in-peritoneal-dialysis
#5
Benjamin Savenkoff, Fleuria Flechon-Meibody, Éric Goffin
Icodextrin is a glucose polymer derived from starch that is used as an osmotic agent in peritoneal dialysis. Its high molecular weight limits blood absorption and is useful for long dwell since there is few osmotic gradient dispersal. Its benefits are numerous: ltrafiltration optimization and better salt and water control especially in anuric patients with a high peritoneal permeability and also in case of infectious peritonitis, glucose sparing with less metabolic complications and a better preservation of peritoneal membrane, better biocompatibility...
December 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29291941/-the-recommendations-of-nephrologist-are-poorly-followed-by-the-primary-care-physician-the-example-of-vaccination-against-hepatitis-b
#6
Yves Dimitrov, Thierry Hannedouche, François Chantrel, Julien Ott, Marc Kribs, Alexandre Klein, Olivier Imhoff, Thierry Krummel
The relationship between specialist physician and primary care physician (PCP) has been poorly evaluated in France. We have studied the application of a specialist's recommendation by the PCP. Vaccination against hepatitis B in patients with chronic renal failure was the follow-up marker. After consultation, the nephrologist wrote in his report to the PCP that the vaccination was recommended. At the next nephrological consultation, the patient was asked if the PCP had proposed vaccination. The clinical, biological characteristics and history of the patients were recorded as well as number and location of the PCP consultations...
December 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29291940/-acute-kidney-injury-in-thromboangiitis-obliterans-disease
#7
Thomas Deffontis, Roland Kintega, Martin Jannot, Philippe Nicoud, William Hanf
Buerger's disease or thombo-angiitis obliterans disease is a small vessel's vasculitis, frequently observed in young and smoker's males. Diagnosis is based on both clinical and radiological arguments. There is no specific treatment designed for this disease. We report the case of 43 years old patient presenting with an acute kidney injury associated with Buerger's disease. We reviewed the different case of kidney disease in this rare disease.
December 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29290619/-a-giant-cell-arteritis-revealing-a-goodpasture-s-syndrome
#8
Pascaline M Alix, Amélie Belloi, Émilie Berthoux, Frédérique Dijoud, Emmanuel Villar, Caroline Pariset
Goodpasture's syndrome is a triad of anti-glomerular basement membrane (anti-GBM) circulating antibodies, glomerulonephritis and pulmonary hemorrhage. We reported a 65-year-old woman with headaches, asthenia and weight loss. Giant cell arteritis was confirmed by temporal artery biopsy. The patient had associated renal condition with moderate acute renal failure, proteinuria and haematuria. Renal biopsy showed extracapillary glomerulonephritis and linear staining of immunoglobulins G along glomerular basement membrane...
December 28, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29289517/-dietary-acid-load-a-novel-target-for-the-nephrologist
#9
Philippe Chauveau, Catherine Lasseur, Céline Nodimar, Mathilde Prezelin-Reydit, Stanislas Trolonge, Christian Combe, Michel Aparicio
The acid production of endogenous origin depends mainly on the metabolism of the food and varies with the nature of these. Of the order of 1mEq/kg/day for contemporary food in industrialized countries, it is reduced by more than one third among vegetarians and close to neutrality among vegans. The dietary acid load is eliminated by the normal kidneys, thus maintaining the acid-base equilibrium. In the setting of CKD, it will overflow the capacities of the nephrons, generating a retention of H+ ions, promoting subclinical acidosis...
December 27, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29287894/-monitoring-of-hypertension-in-patients-orally-treated-by-angiogenesis-inhibitor-in-daily-practice
#10
Lisa Belaid, Sahar Bayat-Makoei, Brigitte Laguerre, Cécile Vigneau
OBJECTIVE: The aim of this study is to measure the monitoring and the incidence of renovascular effects of angiogenesis inhibitors in real population. METHOD: Are included in this descriptive, monocentric, practical study, patients of 18 years old and more, orally treated by angiogenesis inhibitors and monitored in consultation by clinician nurses. The main interest variable is the incidence of hypertension at three months of treatment. RESULTS: From January, 2011 to July, 2014, 324 patients have been included, whose 53% are men...
December 26, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29287893/-tumoral-calcinoses-in-a-chronic-hemodialysis-patient-the-role-of-spect-ct-hybrid-imaging
#11
Aboubakr Matrane, Soufiane Hiroual, Mohamed Aziz Bsiss, Safa Bennani Doubli
INTRODUCTION: Tumoral calcinosis is a rare benign disease, defined by the presence of calcified deposits in periarticular tissues. It can be hereditary or secondary at chronic renal failure at the stage of dialysis. This work illustrates the contribution of single-photon emission computed tomography (SPECT/CT) in the diagnosis and management of tumoral calcinoses in a chronic hemodialysis patient, based on a clinical case. CASE REPORT: A 62-year-old patient, chronic hemodialysis since 24 years, presented a mechanical pain shoulders, knees and hips with limitation of joint mobility...
December 26, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29276083/-left-ventricular-hypertrophy-in-chronic-hemodialysis-patients-at-cnhu-hkm-of-cotonou
#12
Jacques Vigan, Séraphin Ahoui, Dominique Hounsou, Aline Céline Kpèhouédo Goudoté, Jeanne Vehounkpe Sacca
INTRODUCTION: Left ventricular hypertrophy (LVH) is a predictor of mortality in hemodialysis. It takes a very high proportion among cardiovascular complications. OBJECTIVE: It was to determine the frequency of LVH and identify its associated factors among chronic hemodialysis patients of CNHU-HKM. METHODS: This is a cross-sectional, descriptive and analytical, which took place 1st February to 31st October 2014. The sample consisted of patients aged over 15 years, chronic hemodialysis for at least 3 months...
December 21, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29274872/-proton-pump-inhibitors-and-kidney
#13
Geoffroy Desbuissons, Gilbert Deray, Lucile Mercadal
Assumed for a long time to be very well tolerated, proton pump inhibitors (PPIs) are widely prescribed for inpatients and outpatients; often beyond their validated indications. Nevertheless, many very varied side effects (pneumopathy, ischemic heart disease, dementia) have been associated with the PPIs during the last decade. Renal toxicity is mainly the occurrence of acute interstitial nephritis (AIN), related to a drug-class effect, involving cellular immunity. AINs, which occur especially in elderly patients, can be difficult to diagnose, with frequently isolated acute kidney injury, appearing with variable delay after the introduction of PPIs...
December 20, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29223662/-discrepancies-and-confluences-in-perception-between-patients-and-nephrologists-of-chronic-kidney-disease-impact-on-vital-impetus-in-adults-not-undergoing-hemodialysis-results-of-the-french-maeva-study
#14
Jean-Philippe Bertocchio, Thierry Baranger, Myriam Isnard-Rouchon, Philippe Zaoui, Christiane Mousson, Gibert Deray
RATIONALE: The impact of chronic kidney disease (CKD) on vital impetus is poorly documented in patients not undergoing renal dialysis and discrepancies can be observed between patients and physicians in perception of QoL and impact of the disease. METHODS: A self-questionnaire was sent to 1282 French nephrologists and a mirrored self-questionnaire was given to patients (CKD stage 3, 4 or 5) by their nephrologist. Data were collected prospectively and anonymously...
December 6, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29223661/-is-cancer-incidence-different-between-type-2-diabetes-patients-compared-to-non-diabetics-in-hemodialysis-a-study-from-the-rein-registry
#15
Aurélie Le Guillou, Adelaide Pladys, Wahida Kihal, Muriel Siebert, Atman Haddj-Elmrabet, Charlotte Cernon, Anne Bernard, Christophe Charasse, Lise Mandart, Didier Hamel, Tugdual Tanquerel, Bernard Strullu, Christine Richer, Pascale Siohan, Théophile Sawadogo, Juliette Baleynaud, Simona Baluta, Sahar Bayat, Cécile Vigneau
BACKGROUND AND OBJECTIVES: In France, diabetes mellitus is now the second cause of end stage renal disease. In a large previous French national study, we observed that dialyzed diabetics have a significant lower risk of death by cancer. This first study was focused on cancer death but did not investigate cancer incidence. In this context, the aim of this second study was to compare the incidence of cancer in diabetic dialyzed patients compared to non-diabetic dialyzed patients in a French region...
December 6, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29198520/-socioeconomic%C3%A2-inequalities-and%C3%A2-kidney%C3%A2-transplantation
#16
Valérie Châtelet, Thierry Lobbedez, Jérôme Harambat, Sahar Bayat-Makoei, François Glowacki, Cécile Vigneau
Studies at the population level must take into account the effect of social insecurity and socioeconomic inequalities on the patient outcomes. Socioeconomic inequalities depend on many determinants that are socially determined. In renal transplantation, these social determinants are not registered in the databases. The European Deprivation Index (EDI) is a composite index of social vulnerability with a French version. The EDI is an ecological measure of deprivation including the individual perception of basic needs for daily life that is called "subjective poverty"...
November 30, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29198962/-type%C3%A2-1-primary%C3%A2-hyperoxaluria-from%C3%A2-childhood-to%C3%A2-adult-how-to%C3%A2-manage-adequately-medical-therapy-compliance
#17
Marie Leflot, Jean-Marie Krzesinski, Laure Collard, Alexandre Thomas, Marie-Sophie Ghuysen
We report the cases of three young patients suffering from type 1 primary hyperoxaluria, a metabolic genetic disorder characterized by intracellular accumulation of oxalate and which may result in end-stage renal disease with systemic impairment. A number of effective conservative therapeutic means are available for early management of affected children particularly when he is growing older. Despite the demonstrated efficacy of conservative therapy, compliance represents a major and daily challenge. Monitoring therapeutic compliance is thus an important task for physicians in charge of this disease...
November 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29198961/a-case-of-successfully-treated-relapsing-peritoneal-dialysis-associated-peritonitis-caused-by-gordonia-bronchialis-in-a-farmer
#18
Diana Sukackiene, Laurynas Rimsevicius, Silvija Kiveryte, Kristina Marcinkeviciene, Maksim Bratchikov, Dalia Zokaityte, Ramunas Tyla, Agne Laucyte-Cibulskiene, Marius Miglinas
Gordonia species are aerobic, weakly acid-fast, Gram-positive pathogens that rarely cause human infections, usually in immunocompromised patients. It is uncommon bacilli in cases of peritoneal dialysis-related peritonitis. The small number of infections with Gordonia species reported for humans may be stipulated by the difficulty in identifying the organism using conventional techniques. Careful review of Gram stains and modified-acid-fast stains should be done, so that confusion with other actinomycetes is minimized, pending the genotypic identification...
November 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29198960/-distinct-symptoms-and-important-implications-in-a-42-year-old-man
#19
Cécile Picard, Alain Fouilhoux, Charles Chazot, Frédérique Dijoud
No abstract text is available yet for this article.
November 29, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29191576/-comparison-of-citrate-4-and-heparin-as-tunneled-catheters-locking-solution-in-chronic-hemodialysis
#20
Guillaume Chazot, Manolie Mehdi, Christie Lorriaux, Patrik Deleaval, Brice Mayor, Guillaume Jean, Charles Chazot, Sylvain Lechevallier, Oriane Moncel, Cyril Vo-Van, Jean-Marc Hurot
INTRODUCTION: Citrate 4% is an alternative to heparin as catheter-locking solution in chronic hemodialysis patients. We compared catheter dysfunction episodes, dialysis adequacy, plasminogen-tissular activators use and costs according to catheter-locking solution in our centre. METHODS: Prospective, monocentric, cohort study (NephroCare Tassin-Charcot) on 49 prevalent patients in chronic hemodialysis. Two main groups were formed according to the prescription of catheter-locking solution at the beginning of the study (03/02/2016) and followed until 05/10/2016: heparin (n=26) and citrate (n=22)...
November 27, 2017: Néphrologie & Thérapeutique
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